{"id":13908,"date":"2018-12-26T01:00:00","date_gmt":"2018-12-25T17:00:00","guid":{"rendered":"http:\/\/swarma.org\/e4253bf42f\/"},"modified":"2019-01-23T10:48:14","modified_gmt":"2019-01-23T02:48:14","slug":"e4253bf42f","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=13908","title":{"rendered":"Cell \u957f\u6587\u7efc\u8ff0\uff1a\u673a\u5668\u5b66\u4e60\u5982\u4f55\u52a9\u529b\u7f51\u7edc\u751f\u7269\u5b66"},"content":{"rendered":"
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\u00a9<\/span><\/strong><\/span>\u00a0Argonne National Laboratory<\/span><\/strong><\/span><\/p>\n

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\u673a\u5668\u5b66\u4e60\u6b63\u5728\u6210\u4e3a\u73b0\u4ee3\u751f\u7269\u5b66\u7814\u7a76\u4e0d\u53ef\u6216\u7f3a\u7684\u4e00\u90e8\u5206\u3002<\/span>2018\u5e747\u6708\uff0cCell \u6742\u520a\u8f7d\u4e86\u4e00\u7bc7\u7531\u54c8\u4f5b\u5927\u5b66\u548c\u79d1\u7f57\u62c9\u591a\u5927\u5b66\u7814\u7a76\u4eba\u5458\u5b8c\u6210\u7684\u7efc\u8ff0\u6587\u7ae0\uff0c\u4ece<\/span>\u75be\u75c5\u751f\u7269\u5b66\uff0c\u836f\u7269\u53d1\u73b0\uff0c\u5fae\u751f\u7269\u7ec4\u7814\u7a76\u548c\u5408\u6210\u751f\u7269\u5b66\u7b49\u65b9\u9762\uff0c\u8ba8\u8bba\u4e86\u673a\u5668\u5b66\u4e60\u4e0e\u7f51\u7edc\u751f\u7269\u5b66\u4ea4\u53c9\u7814\u7a76\u7684\u673a\u9047\u548c\u6311\u6218\u3002<\/span><\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u672c\u6587\u8f6c\u8f7d\u81ea\u516c\u4f17\u53f7\u201c\u518d\u521b\u4e28Regenesis\u201d\uff0c\u5bf9\u673a\u5668\u5b66\u4e60\u7b80\u4ecb\u90e8\u5206\u6709\u5220\u51cf<\/span>\uff0c\u5b8c\u6574\u5185\u5bb9\u8bf7\u79fb\u6b65\u300a\u7f51\u7edc\u751f\u7269\u5b66\u4e0e\u673a\u5668\u5b66\u4e60\uff1a\u4ec0\u4e48\u662f\u673a\u5668\u5b66\u4e60\u300b<\/a>\u3002\u5408\u6210\u751f\u7269\u5b66\u4f5c\u4e3a\u4e00\u95e8\u8de8\u5b66\u79d1\u7684\u65b0\u5174\u9886\u57df\uff0c\u8bd5\u56fe\u4ece\u5de5\u7a0b\u89d2\u5ea6\u7406\u89e3\u548c\u6784\u5efa\u751f\u547d\u7684\u590d\u6742\u6027\uff0c\u96c6\u667a\u4ff1\u4e50\u90e8\u5c06\u6301\u7eed\u5173\u6ce8\u548c\u62a5\u9053\u5408\u6210\u751f\u7269\u5b66\u9886\u57df\u7684\u524d\u6cbf\u8fdb\u5c55\u3002<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u5168\u6587\u7ea61\u4e07\u5b57\uff0c\u9605\u8bfb\u65f6\u95f4\u7ea6\u4e3a20\u5206\u949f\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u8bba\u6587\u9898\u76ee\uff1a<\/span><\/p>\n

Next-Generation machine learning for biological networks<\/span><\/p>\n

\u8bba\u6587\u4f5c\u8005\uff1a<\/span><\/p>\n

Camacho, D. M., Collins, K. M., Powers, R. K., Costello, J. C., & Collins, J. J<\/span><\/p>\n

\u8bba\u6587\u5730\u5740\uff1a<\/span><\/p>\n

https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(18)30592-0<\/span><\/p>\n<\/blockquote>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u8fc7\u53bb\u7684\u5341\u5e74\u4e2d\uff0c\u901a\u8fc7\u5bf9\u5206\u5b50\u53d8\u91cf\u5982\u57fa\u56e0\uff0c\u86cb\u767d\u8d28\u548c\u4ee3\u8c22\u7269\u4e30\u5ea6\uff0c\u5fae\u751f\u7269\u7ec4\u6210\u548c\u7fa4\u4f53\u9057\u4f20\u53d8\u5f02\u7b49\u8fdb\u884c\u91cf\u5316\uff0c\u751f\u7269\u5b66\u9886\u57df\u4ea7\u751f\u4e86\u5927\u91cf\u9ad8\u5ea6\u590d\u6742\u7684\u6570\u636e\u96c6\uff0c\u4e14\u6570\u636e\u96c6\u7684\u6570\u91cf\u6b63\u5728\u6025\u5267\u589e\u52a0\u3002\u8de8\u7814\u7a76\u5b66\u79d1\u7684\u7814\u7a76\u4e2d\u7ecf\u5e38\u4f1a\u4ea7\u751fPB\u91cf\u7ea7\u7684\u6570\u636e\u3002\u4f8b\u5982\uff0c<\/span>Cancer Genome Atlas<\/span><\/em>\u4ece30,000\u591a\u4e2a\u4e0d\u540c\u764c\u75c7\u7c7b\u578b\u7684\u60a3\u8005\u8eab\u4e0a\u91c7\u96c6\u7684\u6570\u636e\uff0c\u603b\u8ba1\u5df2\u7ecf\u8d85\u8fc72.5 PB\u3002\u7c7b\u4f3c\u9879\u76ee\uff0c\u5982<\/span>Human Microbiome Project<\/span><\/em>,ENCODE Project Consortium<\/em>, \u4ee5\u53ca100,000 Genomes Project<\/em>\u00a0\u7b49\u7b49\u4e5f\u6b63\u5728\u4ea7\u751f\u5927\u91cf\u6570\u636e\u3002<\/span><\/p>\n

\u8fd9\u4e9b\u6570\u636e\u96c6\u63d0\u4f9b\u4e86\u6df1\u5165\u4e86\u89e3\u751f\u7269\u7cfb\u7edf\u548c\u590d\u6742\u75be\u75c5\u6240\u9700\u7684\u539f\u6750\u6599\uff0c\u4f46\u5982\u4f55\u8fdb\u4e00\u6b65\u63a2\u7d22\u8fd9\u4e9b\u6570\u636e\u7684\u4ef7\u503c\u53ea\u80fd\u901a\u8fc7\u66f4\u9ad8\u5c42\u6b21\u7684\u5206\u6790\u8fc7\u7a0b\u6765\u5b9e\u73b0\u3002\u4e0a\u9762\u8bf4\u5230\u7684\u9879\u76ee\u65f6\u523b\u5728\u5411\u6211\u4eec\u8868\u660e\uff1a\u5904\u7406\u5927\u578b\u5f02\u6784\u590d\u6742\u6570\u636e\u96c6\u7684\u5de5\u5177\u548c\u6280\u672f\u6b63\u5728\u53d8\u5f97\u65e0\u6bd4\u91cd\u8981<\/strong>\u3002<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u8fd9\u662f\u673a\u5668\u5b66\u4e60\u548c\u7f51\u7edc\u751f\u7269\u5b66\u4ea4\u53c9\u7684\u673a\u9047\uff0c\u8fd9\u662f\u4e00\u4e2a\u5904\u7406\u751f\u7269\u7f51\u7edc\u548c\u5927\u578b\u591a\u7ef4\u6570\u636e\u96c6\u7684\u7814\u7a76\u9886\u57df\u3002\u673a\u5668\u5b66\u4e60\u7684\u5e94\u7528\u5728\u751f\u7269\u5b66\u4e2d\u53d8\u5f97\u65e0\u5904\u4e0d\u5728\uff0c\u4e0d\u4ec5\u8fd1\u5305\u62ec\u57fa\u56e0\u7ec4\u6ce8\u91ca\uff0c\u800c\u4e14\u8fd8\u5305\u62ec\u5bf9\u86cb\u767d\u8d28\u7ed3\u5408\u7684\u9884\u6d4b\uff0c\u764c\u75c7\u5173\u952e\u8f6c\u5f55\u9a71\u52a8\u56e0\u5b50\u7684\u9274\u5b9a\uff0c\u590d\u6742\u5fae\u751f\u7269\u7fa4\u843d\u4e2d\u4ee3\u8c22\u529f\u80fd\u7684\u9884\u6d4b\uff0c\u548c\u8f6c\u5f55\u8c03\u63a7\u7f51\u7edc\u7684\u8868\u5f81\u7b49\u7b49\u3002<\/span>\u7b80\u800c\u8a00\u4e4b\uff0c\u4efb\u4f55\u53ef\u4ee5\u7528\u6765\u5b66\u4e60\u76f8\u5e94\u7684\u6a21\u5f0f\u5e76\u5e94\u7528\u4e8e\u65b0\u6570\u636e\u96c6\u7684\u4efb\u52a1\u90fd\u5c5e\u4e8e\u673a\u5668\u5b66\u4e60\u7684\u8303\u7574\u3002<\/strong>\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u4e00\u4e2a\u5173\u952e\u7684\u4f18\u52bf\u662f\u53ef\u4ee5\u7528\u6765\u7b5b\u9009\u5927\u91cf\u7684\u6570\u636e\u4ee5\u63a2\u7d22\u53ef\u80fd\u4f1a\u88ab\u5ffd\u7565\u7684\u6a21\u5f0f\u3002\u5728\u751f\u7269\u548c\u751f\u7269\u533b\u5b66\u7814\u7a76\u7684\u5927\u6570\u636e\u65f6\u4ee3\uff0c\u673a\u5668\u5b66\u4e60\u5728\u53d1\u73b0\u590d\u6742\u751f\u7269\u7cfb\u7edf\u7684\u53ef\u9884\u6d4b\u6a21\u5f0f\u65b9\u9762\u8d77\u7740\u5173\u952e\u7684\u4f5c\u7528\u3002<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u968f\u7740\u6211\u4eec\u5728\u751f\u7269\u7cfb\u7edf\u7684\u591a\u4e2a\u5c42\u9762\u4e0a\u6536\u96c6\u5230\u8d8a\u6765\u8d8a\u5e9e\u5927\u4e14\u591a\u6837\u5316\u7684\u6570\u636e\uff0c\u6211\u4eec\u53ef\u4ee5\u5229\u7528\u8fd9\u4e9b\u6570\u636e\u96c6\u8bbe\u8ba1\u76f8\u5e94\u7684\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\uff0c\u5728\u591a\u4e2a\u5c42\u9762\uff08\u4ece\u57fa\u56e0\u8c03\u63a7\u5230\u7269\u79cd\u95f4\u76f8\u4e92\u4f5c\u7528\uff09\u6784\u5efa\u66f4\u590d\u6742\u3001\u66f4\u771f\u5b9e\u7684\u7f51\u7edc\u6a21\u578b\u3002\u00a0<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u7f51\u7edc\u751f\u7269\u5b66\u6d89\u53ca\u7814\u7a76\u751f\u7269\u5206\u5b50\u7684\u590d\u6742\u76f8\u4e92\u4f5c\u7528\uff0c\u8be5\u9886\u57df\u5728\u751f\u7269\u7cfb\u7edf\u5efa\u6a21\u4e2d\u626e\u6f14\u7740\u91cd\u8981\u89d2\u8272\uff0c\u8f85\u4e4b\u4ee5\u8de8\u591a\u4e2a\u591a\u5143\u7ec4\u5b66\u7a0b\u5e8f\u751f\u6210\u7684\u9ad8\u5ea6\u590d\u6742\u7684\u6570\u636e\u96c6\u3002\u7f51\u7edc\u751f\u7269\u5b66\u6d89\u53ca\u5927\u89c4\u6a21\u5185\u751f\u751f\u7269\u7f51\u7edc\uff08\u7cfb\u7edf\u751f\u7269\u5b66\u80cc\u666f\uff09\u7684\u91cd\u5efa\u548c\u5206\u6790\uff0c\u4ee5\u53ca\u5c0f\u89c4\u6a21\u5408\u6210\u57fa\u56e0\u7f51\u7edc\uff08\u5408\u6210\u751f\u7269\u5b66\u80cc\u666f\uff09\u7684\u8bbe\u8ba1\u548c\u6784\u5efa\u3002<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u6b64\u5916\uff0c\u4e0b\u4e00\u4ee3\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u63d0\u4f9b\u7684\u5de5\u5177\u53ef\u4ee5\u589e\u52a0\u8fd9\u4e9b\u7f51\u7edc\u6a21\u578b\u5728\u5404\u79cd\u751f\u7269\u533b\u5b66\u9886\u57df\u4e2d\u7684\u5e94\u7528\u3002\u00a0\u5728\u63a5\u4e0b\u6765\u7684\u5185\u5bb9\u4e2d\uff0c\u6211\u4eec\u5c06\u4f1a\u4ece\u5e94\u7528\u7efc\u8ff0\u3001\u75be\u75c5\u751f\u7269\u5b66\uff0c\u836f\u7269\u5f00\u53d1\uff0c\u5fae\u751f\u7269\u7ec4\u7814\u7a76\u548c\u5408\u6210\u751f\u7269\u5b66\u8fd9\u4e94\u4e2a\u65b9\u9762\u63a2\u8ba8\u7f51\u7edc\u751f\u7269\u5b66\u4e0e\u673a\u5668\u5b66\u4e60\u7684\u4ea4\u53c9\u7814\u7a76\u5c06\u5982\u4f55\u5728\u8fd9\u4e9b\u9886\u57df\u53d1\u6325\u91cd\u8981\u7684\u4f5c\u7528\u3002<\/strong><\/span><\/p>\n

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\u673a\u5668\u5b66\u4e60\u5728\u751f\u7269\u5b66\u4e2d\u7684\u5e94\u7528<\/strong><\/span><\/p>\n

 <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u9009\u62e9\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u5e94\u7528\u4e8e\u751f\u7269\u5b66\u95ee\u9898\u65f6\uff0c\u9700\u8981\u8003\u8651\u51e0\u4e2a\u56e0\u7d20\uff0c\u7279\u522b\u662f\u8003\u8651\u5230\u751f\u7269\u6570\u636e\u7684\u53ef\u53d8\u6027\u4ee5\u53ca\u7528\u4e8e\u6536\u96c6\u6570\u636e\u7684\u4e0d\u540c\u5e73\u53f0\u548c\u65b9\u6cd5\u65f6\u3002\u7531\u4e8e\u6280\u672f\u548c\u751f\u7269\u672c\u8eab\u7684\u5dee\u5f02\uff0c\u5728\u4e00\u4e2a\u6570\u636e\u96c6\u4e0a\u8bad\u7ec3\u7684\u673a\u5668\u5b66\u4e60\u6a21\u578b\u53ef\u80fd\u65e0\u6cd5\u5f88\u597d\u5730\u63a8\u5e7f\u5230\u5176\u4ed6\u6570\u636e\u96c6\u3002<\/strong>\u4efb\u4f55\u65b0\u7684\u6570\u636e\u96c6\u5e94\u8be5\u4e0e\u7528\u4e8e\u8bad\u7ec3\u6a21\u578b\u7684\u6570\u636e\u7684\u4e00\u822c\u5c5e\u6027\u76f8\u5339\u914d\u3002\u65b0\u6570\u636e\u4e5f\u5e94\u8be5\u4f7f\u7528\u4e0e\u8bad\u7ec3\u6570\u636e\u76f8\u540c\u7684\u6d41\u7a0b\u8fdb\u884c\u5904\u7406\u3002\u5982\u679c\u65b0\u6570\u636e\u4e0e\u8bad\u7ec3\u6570\u636e\u5b58\u5728\u663e\u8457\u4e0d\u540c\uff0c\u673a\u5668\u5b66\u4e60\u6a21\u578b\u7684\u9884\u6d4b\u5f88\u53ef\u80fd\u662f\u865a\u5047\u7684\u3002<\/span><\/p>\n

\u4e0e\u5206\u5b50\u751f\u7269\u5b66\u6280\u672f\u975e\u5e38\u76f8\u4f3c\uff0c\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u4e5f\u662f\u8981\u6839\u636e\u7279\u5b9a\u60c5\u5f62\u624d\u80fd\u51b3\u5b9a\u7684\u3002\u673a\u5668\u5b66\u4e60\u548c\u5206\u5b50\u751f\u7269\u5b66\u5b9e\u9a8c\u90fd\u9700\u8981\u4ed4\u7ec6\u7684\u5b9e\u9a8c\u8bbe\u8ba1\u624d\u80fd\u6b63\u786e\u68c0\u9a8c\u5047\u8bbe\u3002\u5c3d\u7ba1\u673a\u5668\u5b66\u4e60\u7684\u76ee\u6807\u662f\u5f00\u53d1\u53ef\u4ee5\u5e7f\u6cdb\u5e94\u7528\u7684\u9884\u6d4b\u6a21\u578b\uff0c\u4f46\u6a21\u578b\u6839\u636e\u4e0d\u540c\u9884\u6d4b\u6761\u4ef6\u53ef\u80fd\u4f1a\u505a\u51fa\u4e0d\u540c\u7684\u5047\u8bbe\uff0c\u5e76\u4e14\u5176\u6027\u80fd\u53ef\u80fd\u4f1a\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u53d1\u751f\u53d8\u5316\u3002\u6240\u6709\u65b9\u6cd5\u7684\u9009\u62e9\u90fd\u9700\u8981\u4f5c\u51fa\u6743\u8861; \u8fd9\u4e2a\u6982\u5ff5\u5728\u8ba1\u7b97\u673a\u79d1\u5b66\u4e2d\u662f\u88ab\u5e7f\u6cdb\u8ba4\u53ef\u7684\uff0c\u79f0\u4e3a\u201cNo free lunch theorem<\/strong>\u201d\u3002<\/span><\/p>\n

\u673a\u5668\u5b66\u4e60\u7684\u6027\u80fd\u53ef\u80fd\u53d7\u591a\u79cd\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u5305\u62ec\u7279\u5f81\u9009\u62e9\uff0c\u7528\u6237\u5b9a\u4e49\u7684\u53c2\u6570\u4ee5\u53ca\u65b9\u6cd5\u672c\u8eab\u3002\u76f4\u63a5\u8bc1\u636e\u8868\u660e\u8fd9\u4e9b\u56e0\u7d20\u662f\u751f\u7269\u5e94\u7528\u4e2d\u5f71\u54cd\u673a\u5668\u5b66\u4e60\u6027\u80fd\u7684\u4e3b\u8981\u56e0\u7d20\u3002\u8fd9\u4e9b\u8bc1\u636e\u53ef\u4ee5\u5728Reverse Engineering Assessment and Methodology\uff08DREAM\uff09Challenge<\/em><\/strong>\u4e2d\u627e\u5230\u3002DREAM Challenge<\/em>\u65e8\u5728\u5bfb\u627e\u7f51\u7edc\u751f\u7269\u5b66\u548c\u533b\u5b66\u4e2d\u5927\u6570\u636e\u7814\u7a76\u95ee\u9898\u7684\u89e3\u51b3\u65b9\u6848\u3002\u4ee5\u524d\u7684\u6311\u6218\u9879\u76ee\u5305\u62ec\u57fa\u56e0\u7ec4\u89c4\u6a21\u8c03\u63a7\u7f51\u7edc\u7684\u63a8\u65ad\u4ee5\u53ca\u4f7f\u7528\u591a\u5143\u6570\u636e\u96c6\u5bf9\u836f\u7269\u654f\u611f\u6027\u548c\u534f\u540c\u4f5c\u7528\u7684\u9884\u6d4b\u3002\u8bb8\u591a\u751f\u7269\u7f51\u7edc\u63a8\u65ad\u65b9\u6cd5\u53ef\u4ee5\u88ab\u5b9a\u4e49\u4e3a\u65e0\u76d1\u7763\u5b66\u4e60\uff0c\u5176\u4e2d\u8f93\u5165\u6570\u636e\u7528\u4e8e\u5728\u7ed9\u5b9a\u4e00\u7ec4\u5b9e\u9a8c\u6570\u636e\u96c6\u7684\u60c5\u51b5\u4e0b\u9884\u6d4b\u751f\u7269\u5206\u5b50\uff08\u7279\u5f81\uff0cfeature\uff09\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff08\u8fb9\u7f18\uff0cedges\uff09\u3002\u7b2c\u4e8c\u7c7b\u751f\u7269\u7f51\u7edc\u63a8\u7406\u7b97\u6cd5\u4f7f\u7528\u76d1\u7763\u5b66\u4e60\u65b9\u6cd5\u5bf9\u65b0\u6837\u672c\u8fdb\u884c\u9884\u6d4b\u3002\u6b64\u7c7b\u65b9\u6cd5\u5728\u8868\u5f81\u836f\u7269\u4f5c\u7528\u673a\u5236\u6216\u75be\u75c5\u72b6\u6001\u9a71\u52a8\u56e0\u7d20\u65b9\u9762\u53d6\u5f97\u4e86\u91cd\u5927\u7684\u6210\u529f\u3002<\/strong><\/span><\/p>\n

\"\u96c6\u667a\"<\/p>\n

\n

\u00a0\u56fe2. DREAM Challenge.\u00a0<\/span><\/strong><\/p>\n

\u00a0<\/span><\/p>\n

\n

\u94fe\u63a5\uff1ahttp:\/\/dreamchallenges.org\/<\/span><\/p>\n<\/blockquote>\n

\u6bcf\u4e2aDREAM Challenge<\/em>\u5411\u7f51\u7edc\u751f\u7269\u5b66\u7814\u7a76\u754c\u63d0\u51fa\u4e00\u4e2a\u5177\u4f53\u95ee\u9898\u548c\u89e3\u51b3\u5b83\u7684\u5fc5\u8981\u6570\u636e\u3002\u8fd9\u4e9b\u95ee\u9898\u9700\u8981\u5229\u7528\u8ba1\u7b97\u6a21\u578b\uff08\u901a\u5e38\u662f\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\uff09\u6765\u89e3\u51b3\uff0c\u4f46\u5bf9\u5e94\u7528\u7684\u6a21\u578b\u7c7b\u578b\u6ca1\u6709\u9650\u5236\u3002\u6bcf\u4e2a\u6311\u6218\u90fd\u5305\u542b\u4e00\u4e2a\u9690\u85cf\u7684\u8bc4\u4f30\u6570\u636e\u96c6\uff0c\u7528\u4e8e\u8bc4\u4f30\u6bcf\u79cd\u65b9\u6cd5\u7684\u6027\u80fd\uff0c\u4ece\u800c\u63d0\u4f9b\u72ec\u7acb\u7684\uff0c\u65e0\u504f\u89c1\u7684\u8bc4\u4f30\u6765\u8bc4\u4f30\u4e0d\u540c\u7684\u65b9\u6cd5\u3002\u968f\u7740\u51e0\u5341\u4e2a\u6311\u6218\u5df2\u7ecf\u5b8c\u6210\uff0c\u6211\u4eec\u53ef\u4ee5\u5927\u81f4\u603b\u7ed3\u51fa\u4e09\u6761\u201c\u7ecf\u9a8c\u6cd5\u5219\u201d\uff0c\u4e3a\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u5728\u7f51\u7edc\u751f\u7269\u5b66\u4e2d\u5e94\u7528\u63d0\u4f9b\u501f\u9274\uff1a<\/strong><\/span><\/p>\n

\uff081\uff09\u201c\u7b80\u5355\u201d\u901a\u5e38\u66f4\u597d\uff08Simple is often better\uff09<\/strong>\uff1a\u4e0d\u7ba1\u6311\u6218\u5982\u4f55\uff0c\u51e0\u4e4e\u53ef\u4ee5\u80af\u5b9a\u7684\u662f\uff0c\u4e00\u4e2a\u7b80\u5355\u7684\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u5c06\u6210\u4e3a\u8868\u73b0\u6700\u4f73\u7684\u6a21\u578b\u3002\u8fd9\u4e9b\u6a21\u578b\u901a\u5e38\u5305\u62ec\u57fa\u4e8e\u7ebf\u6027\u56de\u5f52\u7684\u6a21\u578b\uff08\u4f8b\u5982\u5f39\u6027\u7f51\u7edc\uff09\uff0c\u8fd9\u4e9b\u6a21\u578b\u5728\u4e00\u7cfb\u5217\u673a\u5668\u5b66\u4e60\u4efb\u52a1\u4e2d\u8868\u73b0\u826f\u597d\uff0c\u56e0\u6b64\u5177\u6709\u51fa\u8272\u7684\u8d77\u70b9\u3002<\/span><\/p>\n

\uff082\uff09\u5148\u9a8c\u77e5\u8bc6\u63d0\u9ad8\u6027\u80fd\uff08Prior knowledge improves performance\uff09<\/strong>\uff1a\u9886\u57df\u7279\u5b9a\u77e5\u8bc6\u7684\u5e94\u7528\u51e0\u4e4e\u603b\u662f\u6709\u52a9\u4e8e\u4efb\u4f55\u9884\u6d4b\u6a21\u578b\u3002\u4f8b\u5982\uff0c\u4f7f\u7528\u78f7\u9178\u86cb\u767d\u8d28\u7ec4\u5b66\u6570\u636e\u6765\u5bf9\u4e73\u817a\u764c\u4e2d\u7684\u4fe1\u53f7\u4f20\u5bfc\u7f51\u7edc\u53cd\u5411\u5de5\u7a0b\u3002\u4fe1\u53f7\u7f51\u7edc\u4e2d\u5143\u4ef6\u548c\u76f8\u4e92\u4f5c\u7528\u7684\u5148\u9a8c\u77e5\u8bc6\u589e\u5f3a\u4e86\u673a\u5668\u5b66\u4e60\u9884\u6d4b\u4fe1\u53f7\u76f8\u4e92\u4f5c\u7528\u7684\u80fd\u529b\u3002<\/span><\/p>\n

\uff083\uff09<\/span>\u96c6\u6210\u6a21\u578b\u4ea7\u751f\u7684\u7ed3\u679c\u66f4\u52a0\u7a33\u5065\uff08Ensemble models produce robust results\uff09<\/strong>\uff1a\u5728\u5f00\u59cb\u6211\u4eec\u8ba8\u8bba\u8fc7\uff0c\u96c6\u6210\u6a21\u578b\u6574\u5408\u6765\u81ea\u591a\u4e2a\u72ec\u7acb\u9884\u6d4b\u65b9\u6cd5\u7684\u9884\u6d4b\u3002\u96c6\u6210\u6a21\u578b\u5728\u5404\u79cd\u6311\u6218\u4e2d\u4e00\u76f4\u662f\u6700\u4f73\u7684\u6a21\u578b\u9009\u62e9\uff0c\u5e76\u4e14\u5f80\u5f80\u9c81\u68d2\u6027\u66f4\u9ad8\u3002<\/span><\/p>\n

\u5728\u4e0d\u540c\u7684DREAM Challenge<\/em>\u4e2d\uff0c\u53ef\u4ee5\u770b\u51fa\uff0c\u6ca1\u6709\u4efb\u4f55\u4e00\u79cd\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u6216\u4e00\u7c7b\u65b9\u6cd5\u603b\u662f\u8868\u73b0\u6700\u4f73\u3002\u56e0\u6b64\uff0c\u6ca1\u6709\u201cmagic bullet<\/strong>\u201d\u65b9\u6cd5\u53ef\u4ee5\u6700\u4f18\u5730\u89e3\u51b3\u7f51\u7edc\u751f\u7269\u5b66\u4e2d\u7684\u6240\u6709\u673a\u5668\u5b66\u4e60\u4efb\u52a1\u3002<\/span><\/p>\n

\n

\"\u96c6\u667a\"<\/p>\n

\n

\n
\n
\n

\u75be\u75c5\u751f\u7269\u5b66<\/strong><\/span><\/p>\n

 <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u7f51\u7edc\u751f\u7269\u5b66\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u66f4\u597d\u5730\u7406\u89e3\u75be\u75c5\u7684\u590d\u6742\u6027\u3002<\/span> \u4f20\u7edf\u65b9\u6cd5\u4f9d\u8d56\u4e8e\u75be\u75c5\u7279\u5b9a\u65b9\u9762\u7684\u8bc6\u522b\u548c\u7279\u5f81\u63cf\u8ff0\uff0c\u4f8b\u5982\u75be\u75c5\u76f8\u5173\u57fa\u56e0\u7684\u53d1\u73b0\uff0c\u800c\u7f51\u7edc\u751f\u7269\u5b66\u91c7\u53d6\u7684\u662f\u66f4\u52a0\u5168\u9762\u7684\u65b9\u6cd5\uff0c\u56e0\u6b64\uff0c\u7f51\u7edc\u751f\u7269\u5b66\u5c06\u4e3a\u6211\u4eec\u63ed\u793a\u66f4\u52a0\u5168\u9762\u7684\u75be\u75c5\u8868\u578b\u9a71\u52a8\u56e0\u7d20\u7684\u4fe1\u606f\u3002<\/span> \u7f51\u7edc\u751f\u7269\u5b66\u4e0d\u662f\u7b80\u5355\u5730\u8bc6\u522b\u6f5c\u5728\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u800c\u662f\u8ba9\u6211\u4eec\u80fd\u591f\u5bf9\u75be\u75c5\u72b6\u6001\u4e2d\u81f3\u5173\u91cd\u8981\u7684\u751f\u7269\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u7684\u7f51\u7edc\u548c\u5b50\u7f51\u7edc\u8fdb\u884c\u63cf\u8ff0\u3002<\/span><\/span><\/p>\n

\u5728\u5b9a\u4e49\u75be\u75c5\u7684\u7f51\u7edc\u7279\u5b9a\u7279\u5f81\u65f6\uff0c\u53ef\u4ee5\u5408\u7406\u5730\u4f7f\u7528\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u6765\u5e2e\u52a9\u7406\u89e3\u548c\u5b9a\u4e49\u6f5c\u5728\u7684\u75be\u75c5\u673a\u5236\u3002<\/span><\/strong>\u6bd4\u5982\uff0c\u53ef\u4ee5\u4f7f\u7528\u6765\u81ea\u8bf8\u5982<\/span>BioGRID<\/span>\u6765\u6e90\u7684\u73b0\u6709\u751f\u7269\u7f51\u7edc\u77e5\u8bc6\uff0c\u63a2\u7d22\u4e0e\u5065\u5eb7\u72b6\u6001\u76f8\u6bd4\uff0c\u4e0d\u540c\u751f\u7269\u5206\u5b50\u4e4b\u95f4\u7684\u5173\u7cfb\u5982\u4f55\u5728\u75be\u75c5\u72b6\u6001\u4e2d\u53d1\u751f\u53d8\u5316<\/span>\uff08BioGRID\u662f\u4e00\u4e2a\u5173\u4e8e<\/span>\u57fa\u56e0\u76f8\u4e92\u4f5c\u7528\uff0c\u86cb\u767d\u8d28<\/span> –<\/span> \u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff0c\u5316\u5b66\u76f8\u4e92\u4f5c\u7528\uff0c\u7ffb\u8bd1\u540e\u4fee\u9970\u7684\u6570\u636e\u5e93\uff09<\/span>\u3002<\/span>\u4ece<\/span>\u5065\u5eb7\u961f\u5217\u7684\u6570\u636e<\/span>\u5f00\u59cb\uff0c\u6211\u4eec<\/span>\u53ef<\/span>\u4ee5\u8bad\u7ec3\u6df1\u5ea6\u5b66\u4e60\u7b97\u6cd5\uff08\u4f8b\u5982\uff0c\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc\uff09\u6765\u5b66\u4e60\u548c\u5b9a\u4e49\u5065\u5eb7\u72b6\u6001\u7684\u57fa\u672c\u7279\u5f81\u3002\u8bad\u7ec3\u540e\uff0c\u6211\u4eec\u53ef\u4ee5\u5c06\u6765\u81ea\u60a3\u8005\u7fa4\u4f53\u7684\u6570\u636e<\/span>\u63d0\u4f9b\u7ed9\u7b97\u6cd5<\/span>\uff0c\u5e76\u7528\u4e8e\u9884\u6d4b\u5065\u5eb7\u72b6\u6001\u548c\u75be\u75c5\u72b6\u6001\u4e4b\u95f4\u7684\u5dee\u5f02\u7b49\u5e94\u7528\u3002<\/span><\/span><\/p>\n

\u6211\u4eec\u9700\u8981\u66f4\u597d\u5730\u4e86\u89e3\u75be\u75c5\u80cc\u540e\u751f\u7269\u7f51\u7edc\u7684\u590d\u6742\u7ed3\u6784\uff0c\u4ee5\u53ca\u8fd9\u4e9b\u7f51\u7edc\u7684\u5931\u8c03\u5982\u4f55\u53ef\u80fd\u5bfc\u81f4\u67d0\u79cd\u75be\u75c5\u72b6\u6001\u3002\u5728\u8fd9\u65b9\u9762\uff0c<\/span>\u80f6\u56ca\u7f51\u7edc\uff08Capsule networks\uff09<\/span>\uff0c\u53ef\u80fd\u5177\u6709\u5f88\u9ad8\u7684\u5e94\u7528\u4ef7\u503c\u3002<\/span>\u80f6\u56ca\u7f51\u7edc\u6d89\u53ca\u4e00\u79cd\u65b0\u578b\u7684\u795e\u7ecf\u7f51\u7edc\u67b6\u6784\uff0c\u5176\u4e2d<\/span>CNN<\/span>\u88ab\u5c01\u88c5\u5728\u76f8\u4e92\u8fde\u63a5\u7684\u6a21\u5757\u4e2d\u3002<\/span><\/strong>\u5982\u524d\u6240\u8ff0\uff0c<\/span>CNN<\/span>\u662f\u5904\u7406\u591a\u7ef4\u6570\u636e\u7684\u4e00\u79cd\u7279\u6b8a\u7684\u6df1\u5c42\u795e\u7ecf\u7f51\u7edc\uff0c\u4f8b\u5982\u7f51\u7edc\u751f\u7269\u5b66\u4e2d\u53d1\u73b0\u7684\u7ec4\u5b66\u6570\u636e\u96c6\u3002<\/span>\u53e6\u4e00\u65b9\u9762\uff0c\u80f6\u56ca\u7f51\u7edc\u662f\u5c06\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc\u8868\u793a\u4e3a\u4e00\u7ec4\u6a21\u5757\uff08\u80f6\u56ca\uff09\u7684\u4ee3\u8868\uff0c\u5176\u5141\u8bb8\u4ee5\u4fdd\u6301\u6570\u636e\u672c\u8eab\u5206\u5c42\u7ed3\u6784\u7684\u65b9\u5f0f\u6765\u5b66\u4e60\u6570\u636e\u7ed3\u6784\u3002<\/span>\u8fd9\u5728\u56fe\u50cf\u6570\u636e\u5206\u6790\u4e2d\u7279\u522b\u6709\u7528\uff0c\u56e0\u4e3a\u5b83\u5141\u8bb8\u7b97\u6cd5\u5b66\u4e60\u72ec\u7acb\u4e8e\u56fe\u50cf\u89c6\u89d2\u7684\u56fe\u50cf\u7279\u5f81\u3002<\/span><\/span><\/p>\n

\u8003\u8651\u5230\u751f\u7269\u7f51\u7edc\u672c\u8d28\u4e0a\u662f\u9ad8\u5ea6\u6a21\u5757\u5316\u7684\uff0c\u80f6\u56ca\u7f51\u7edc\u5df2\u7ecf\u53ef\u4ee5\u6210\u719f\u7684\u5e94\u7528\u4e8e\u7f51\u7edc\u751f\u7269\u5b66\u548c\u75be\u75c5\u751f\u7269\u5b66\uff1a<\/span>\u80f6\u56ca\u7f51\u7edc\u4e3a\u751f\u7269\u5206\u5b50\u6307\u5b9a\u5c42\uff0c\u540c\u65f6\u5141\u8bb8\u6bcf\u4e00\u5c42\u4e0e\u5176\u4ed6\u5c42\u76f8\u4e92\u4f5c\u7528\u3002\u6bcf\u4e2a\u751f\u7269\u5c42\u53ef\u4ee5\u88ab\u89c6\u4e3a\u80f6\u56ca<\/span>\u3002<\/span>\u6a2a\u8de8\u4e0d\u540c\u751f\u7269\u5c42\u4ea7\u751f\u7684\u6570\u636e\uff08\u4f8b\u5982\u8f6c\u5f55\u7ec4\u5b66\uff0c\u86cb\u767d\u8d28\u7ec4\u5b66\uff0c\u4ee3\u8c22\u7ec4\u5b66\uff09\u53ef\u4ee5\u8bad\u7ec3\u4e0e\u6bcf\u4e2a\u80f6\u56ca\u76f8\u5173\u7684<\/span>CNN\u4ece\u800c<\/span>\u72ec\u7acb\u5730\u4e86\u89e3\u8fd9\u4e9b\u5c42\u4e2d\u7684\u7279\u5b9a\u6027\u8d28\u3002<\/span><\/strong>\u5728<\/span>\u80f6\u56ca\u4e4b\u95f4\u5e94\u7528\u52a8\u6001\u8def\u7531\uff08Dynamic routing\uff09\u7684\u524d\u63d0\u5c06\u5141\u8bb8\u4e0d\u540c\u80f6\u56ca\u5c06\u4efb\u4f55\u5176\u4ed6\u80f6\u56ca\u7684\u8f93\u51fa\u4f5c\u4e3a\u8f93\u5165\uff0c\u4ece\u800c\u4f7f\u6a21\u578b\u80fd\u591f\u4e86\u89e3\u6bcf\u4e2a\u5c42\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u548c\u4f9d\u8d56\u6027\u3002<\/span><\/span>\u8fd9\u79cd\u65b9\u6cd5\u5c06\u5141\u8bb8\u4eba\u4eec\u7814\u7a76\u9ad8\u5ea6\u6a21\u5757\u5316\u7684\u7cfb\u7edf\uff0c\u5982\u7531\u57fa\u56e0\uff0c\u86cb\u767d\u8d28\uff0c\u4ee3\u8c22\u7269\u7b49\u7ec4\u6210\u7684\u751f\u7269\u7f51\u7edc\uff0c\u5e76\u5206\u6790\u8fd9\u4e9b\u7f51\u7edc\u53ca\u5176\u5b50\u7f51\u7edc\u7684\u529f\u80fd\u7ec4\u7ec7\u548c\u76f8\u4e92\u4f5c\u7528\u5728\u75be\u75c5\u72b6\u6001\u5982\u4f55\u88ab\u7834\u574f\u3002<\/span><\/span><\/p>\n

\u6211\u4eec\u5e76\u6ca1\u6709\u6ce8\u610f\u5230\u80f6\u56ca\u7f51\u7edc\u7684\u4efb\u4f55\u751f\u7269\u5b66\u5e94\u7528\uff0c\u4f46\u5b83\u4eec\u7684\u72ec\u7279\u7279\u5f81\u53ef\u4ee5\u4f7f\u6211\u4eec\u80fd\u591f\u89e3\u5f00\u548c\u89e3\u51b3\u4eba\u7c7b\u75be\u75c5\u7684\u590d\u6742\u6027\u3002<\/span> \u6b63\u5982\u6211\u4eec\u4e0b\u9762\u6240\u63cf\u8ff0\u7684\u90a3\u6837\uff0c\u80f6\u56ca\u7f51\u7edc\u548c\u5176\u4ed6\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u7684\u6210\u529f\u5b9e\u65bd\u5c06\u53d6\u51b3\u4e8e\u9002\u5f53\u5927\u3001\u9ad8\u8d28\u91cf\u3001\u6ce8\u91ca\u826f\u597d\u7684\u6570\u636e\u96c6\u7684\u53ef\u7528\u6027\u3002<\/span><\/strong><\/span><\/p>\n

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\u836f\u7269\u5f00\u53d1<\/strong><\/span><\/p>\n

 <\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n<\/section>\n

\u5728\u836f\u7269\u5f00\u53d1\u4e2d\uff0c\u6211\u4eec\u8feb\u5207\u9700\u8981\u8868\u5f81\u5316\u5408\u7269\u7684\u4f5c\u7528\u65b9\u5f0f\u3001\u8bc6\u522b\u836f\u7269\u7684\u8131\u9776\u6548\u5e94\u5e76\u5f00\u53d1\u6709\u6548\u7684\u836f\u7269\u7ec4\u5408\u6765\u6cbb\u7597\u590d\u6742\u75be\u75c5\u3002<\/span>\u00a0<\/span>\u7f51\u7edc\u751f\u7269\u5b66\u4ee5\u53ca\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u5df2\u6210\u529f\u5e94\u7528\u4e8e\u8fd9\u4e9b\u9886\u57df\uff0c\u4f8b\u5982\uff0c\u7f51\u7edc\u6a21\u578b\u548c\u8f6c\u5f55\u7ec4\u5b66\u5df2\u88ab\u7528\u4e8e\u9884\u6d4b\u5316\u5408\u7269\u7684\u53ef\u80fd\u9776\u6807\u3002<\/span>\u00a0<\/span>\u7136\u800c\uff0c\u8fd9\u65b9\u9762\u4ecd\u7136\u5b58\u5728\u8bf8\u591a\u6311\u6218\uff0c\u7279\u522b\u662f\u5728\u7f29\u5c0f\u836f\u7269\u53d1\u5f00\u53d1\u4e2d\u751f\u7269\u5c42\u6b21\u548c\u5316\u5b66\u5c42\u6b21\u7684\u5dee\u5f02\u3002<\/span><\/strong>\u00a0<\/span>\u4e0b\u9762\uff0c\u6211\u4eec\u91cd\u70b9\u4ecb\u7ecd\u4e0b\u4e00\u4ee3\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u5c06\u5982\u4f55\u5728\u7f51\u7edc\u751f\u7269\u5b66\u7684\u80cc\u666f\u4e0b\u89e3\u51b3\u8fd9\u4e9b\u6311\u6218\u5e76\u52a0\u901f\u836f\u7269\u53d1\u73b0\u548c\u5f00\u53d1\u8fc7\u7a0b\u3002<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u6765\u81ea\u836f\u7269\u6cbb\u7597\u7684\u591a\u7ec4\u5b66\u6570\u636e\uff0c\u4ee5\u53ca\u5b58\u50a8\u5728\u5982<\/span>dbGAP<\/span>\u548c<\/span>GTEx Portal<\/span>\u7b49\u5b58\u50a8\u5e93\u4e2d\u7684\u5927\u91cf\u57fa\u56e0\u578b\u6570\u636e\uff0c\u4e3a\u5229\u7528<\/span>\u673a\u5668\u5b66\u4e60<\/span>\u751f\u6210<\/span>\u7efc\u5408\u7f51\u7edc\u6a21\u578b\u5e26\u6765\u4e86\u6240\u9700\u8981\u7684\u539f\u59cb\u751f\u7269\u6750\u6599\u3002\u4ece\u673a\u5668\u5b66\u4e60\u7684\u89d2\u5ea6\u51fa\u53d1\uff0c\u601d\u8003\u5982\u4f55\u5c06\u8fd9\u4e9b\u7f51\u7edc\u6a21\u578b\u4e0e\u751f\u5316\u4e0a\u53ef\u83b7\u5f97\u7684\u4e30\u5bcc\u4fe1\u606f\u7ed3\u5408\u8d77\u6765<\/span>\u662f\u53ca\u5176\u4ee4\u4eba\u6fc0\u52a8\u7684\u3002<\/span><\/span><\/p>\n

\u591a\u4efb\u52a1\u5b66\u4e60\u795e\u7ecf\u7f51\u7edc\uff08Multi-task-learning neural networks\uff09\u975e\u5e38\u9002\u5408\u8fd9\u79cd\u7c7b\u578b\u7684\u5e94\u7528\u3002\u8fd9\u7c7b\u5e94\u7528\u7684\u7279\u70b9\u662f\u7ed9\u5b9a\u7684\u7cfb\u7edf\u4e2d\u5305\u62ec\u6a2a\u8de8\u591a\u79cd\u6570\u636e\u7c7b\u578b\uff08\u4f8b\u5982\uff0c\u8868\u8fbe\u8c31\uff0c\u5316\u5b66\u7ed3\u6784\uff09\u3001\u5305\u542b\u591a\u79cd\u6807\u7b7e\uff08\u4f8b\u5982\u5bf9\u836f\u7269\uff0c\u75be\u75c5\u72b6\u6001\u7684\u54cd\u5e94\uff09\u7684\u6570\u636e\u7279\u5f81\u3002<\/span><\/strong>\u5178\u578b\u7684\u673a\u5668\u5b66\u4e60\u5e94\u7528\u7a0b\u5e8f\u5b9a\u4e49\u4e86\u4e00\u4e2a\u5355\u4e00\u7684\u4efb\u52a1\uff0c\u5176\u4e2d\u6a21\u578b\u88ab\u8bad\u7ec3\u4ee5\u9884\u6d4b\u5355\u4e2a\u6807\u7b7e\u3002\u5982\u679c\u4f7f\u7528\u76f8\u540c\u7684\u8f93\u5165\u6570\u636e\u5b66\u4e60\u65b0\u7684\u6807\u7b7e\uff0c\u5219\u65b0\u7684\u6a21\u578b\u4f1a\u88ab\u8bad\u7ec3\u51fa\u6765\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u5b66\u4e60\u4efb\u52a1\u88ab\u89c6\u4e3a\u72ec\u7acb\u4e8b\u4ef6\u3002<\/span>\u4f46\u662f\uff0c\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u4ece\u4e00\u4e2a\u4efb\u52a1\u4e2d\u5b66\u4e60\u5230\u7684\u91cd\u8981\u4fe1\u606f\uff0c\u53ef\u4ee5\u7528\u4e8e\u53e6\u4e00\u4e2a\u4efb\u52a1\u7684\u5b66\u4e60\u8fc7\u7a0b\u3002<\/span>\u591a\u4efb\u52a1\u5b66\u4e60\u7684\u57fa\u672c\u601d\u60f3\u662f\u540c\u65f6\u5171\u540c\u5b66\u4e60\u4e00\u7ec4\u4efb\u52a1\u3002\u5355\u4efb\u52a1\u5b66\u4e60\u7684\u76ee\u6807\u662f\u4f18\u5316\u5355\u4e2a\u4efb\u52a1\u7684\u6027\u80fd\uff0c\u800c\u591a\u4efb\u52a1\u5b66\u4e60\u7684\u76ee\u6807\u662f\u4f18\u5316\u6240\u6709\u4efb\u52a1\u7684\u6027\u80fd\u3002\u591a\u4efb\u52a1\u5b66\u4e60\u901a\u8fc7\u591a\u79cd\u8868\u5f81\u6765\u5b66\u4e60\u6574\u4e2a\u7cfb\u7edf\uff0c\u4ece\u800c\u4e00\u6b21\u6027\u5b66\u4e60\u591a\u9879\u4efb\u52a1\u3002<\/strong><\/span><\/span><\/p>\n

\u591a\u4efb\u52a1\u5b66\u4e60\u540c\u65f6\u5b66\u4e60\u591a\u4e2a\u76f8\u5173\u4efb\u52a1\uff0c\u5e76\u4e14\u5e73\u8861\u4efb\u52a1\u4e4b\u95f4\u7684\u5dee\u5f02\u548c\u76f8\u4f3c\u6027\u3002\u8fd9\u79cd\u65b9\u6cd5\u57fa\u4e8e\u8fd9\u6837\u4e00\u4e2a\u524d\u63d0\uff1a\u5b66\u4e60\u76f8\u5173\u8054\u7684\u6982\u5ff5\u53ef\u4ee5\u5f3a\u52a0\u5b66\u4e60\u6a21\u578b\u7684\u4e00\u822c\u5316\uff0c\u63d0\u9ad8\u6027\u80fd\u7684\u540c\u65f6\u4e5f\u907f\u514d\u4e86\u6a21\u578b\u7684\u8fc7\u5ea6\u62df\u5408\u3002<\/span>\u91cd\u8981\u7684\u662f\uff0c\u591a\u4efb\u52a1\u5b66\u4e60\u795e\u7ecf\u7f51\u7edc\u53ef\u4ee5\u6574\u5408\u6216\u5408\u6210\u6765\u81ea\u4e0d\u540c\u6765\u6e90\u548c\u5206\u6790\u65b9\u6cd5\u7684\u6570\u636e\u3002\u56e0\u6b64\uff0c\u591a\u4efb\u52a1\u5b66\u4e60\u53ef\u4ee5\u540c\u65f6\u8003\u8651\u8c03\u63a7\u7f51\u7edc\u7684\u4f5c\u7528\u5173\u7cfb\u3001\u6765\u81ea\u591a\u7ec4\u5b66\u5b9e\u9a8c\u7684\u6570\u636e\u3001\u9ad8\u901a\u91cf\u836f\u7269\u7b5b\u9009\u6570\u636e\u3001\u751f\u7269\u6d3b\u6027\u5206\u6790\u4ee5\u53ca\u836f\u7269\u6cbb\u7597\u7684\u8868\u578b\u89c2\u5bdf\u7b49\u591a\u4e2a\u5c42\u9762\u6765\u9884\u6d4b\u7ed9\u5b9a\u836f\u7269\u7684\u751f\u7406\u53cd\u5e94\u53ca\u5176\u6bd2\u6027\u526f\u4f5c\u7528\u3002<\/span><\/span><\/p>\n

\"\u96c6\u667a\"<\/p>\n

\n

\u901a\u8fc7\u5c06\u5316\u5b66\u5b9e\u4f53\u7684\u7ed3\u6784\u5316\u6570\u636e\u7ed3\u5408\u8d77\u6765\uff0c\u6211\u4eec\u6709\u53ef\u80fd\u5229\u7528\u591a\u4efb\u52a1\u5b66\u4e60\u6765\u5f25\u5408\u836f\u7269\u53d1\u73b0\u7684\u751f\u7269\u548c\u5316\u5b66\u65b9\u9762\u7684\u5dee\u5f02\u3002\u4f8b\u5982\uff0c\u53ef\u4ee5\u4f7f\u7528\u7b80\u5316\u7684\u5206\u5b50\u8f93\u5165-\u884c\u8f93\u5165\u7cfb\u7edf\uff08Simplified molecular-input line-entry system,\u00a0<\/span>SMILES<\/span>\uff09\u8fd9\u79cd\u836f\u7269\u8868\u793a\u65b9\u6cd5\u4f5c\u4e3a\u6a21\u578b\u8f93\u5165\u6570\u636e\u3002<\/span> SMILES<\/span>\u8868\u793a\u6cd5\u5c06\u5316\u5b66\u7269\u8d28\u7684\u7ed3\u6784\u8f6c\u6362\u4e3a\u7ebf\u6027\u6587\u672c\u4e32\uff0c\u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u5c06\u5176\u7eb3\u5165\u673a\u5668\u5b66\u4e60\u5e94\u7528\u7a0b\u5e8f\u4e2d\u3002\u5c06<\/span><\/span>SMILES\u6587\u672c\u4e32\u3001<\/span>\u4e0d\u540c\u5316\u5408\u7269\u7684\u9776\u6807\u4ee5\u53ca\u5176\u8f6c\u5f55\u548c\u6bd2\u6027\u7684\u76f8\u5173\u6570\u636e\u63d0\u4f9b\u7ed9\u591a\u4efb\u52a1\u5b66\u4e60\u7b97\u6cd5\uff0c\u53ef\u4ee5\u7528\u6765\u9884\u6d4b\u65b0\u5316\u5408\u7269\u7684\u6f5c\u5728\u526f\u4f5c\u7528\u6216\u53ef\u80fd\u9776\u6807\u3002\u6b64\u5916\uff0c\u6211\u4eec\u8fd8\u53ef\u4ee5\u4f7f\u7528\u81ea\u7136\u8bed\u8a00\u5904\u7406\u6280\u672f\uff0c\u5982\u8bcd\u5d4c\u5165\u6280\u672f\uff0c\u5b66\u4e60\u57fa\u4e8e<\/span>SMILES\u7684<\/span>\u836f\u7269\u7684\u7279\u5b9a\u5c5e\u6027\uff0c\u8fd9\u6837\u4e00\u6765\u4e0d\u4ec5\u53ef\u4ee5\u5bf9\u591a\u4efb\u52a1\u5b66\u4e60\u8fdb\u884c\u8865\u5145\uff0c\u540c\u65f6\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u5728\u968f\u540e\u7684\u836f\u7269\u8bbe\u8ba1\u5de5\u4f5c\u4e2d\u52a0\u5165\u6216\u53bb\u9664\u67d0\u4e9b\u5316\u5408\u7269\u7684\u5173\u952e\u7279\u6027\u548c<\/span>\/<\/span>\u6216\u7ed3\u6784\u7279\u5f81\u3002<\/span><\/span><\/p>\n

\u8fd9\u4e9b\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u4e5f\u53ef\u4ee5\u7528\u6765\u7814\u7a76\u548c\u5229\u7528\u836f\u7269\u5316\u5408\u7269\u7684<\/span>\u201c<\/span>\u80ae\u810f<\/span>\u201d<\/span>\u3002<\/span><\/span><\/strong>\u5927\u591a\u6570\uff08\u5982\u679c\u4e0d\u662f\u5168\u90e8\uff09\u5316\u5408\u7269\u5bf9\u4eba\u4f53\u7684\u5f71\u54cd\u8d85\u8fc7\u5176\u6cbb\u7597\u7684\u76ee\u7684\uff0c\u5e76\u4e14\u8fd9\u4e9b\u5f71\u54cd\u4ee5\u5242\u91cf\u548c\u7f51\u7edc\u4f9d\u8d56\u7684\u65b9\u5f0f\u53d8\u5316\u3002\u591a\u4efb\u52a1\u5b66\u4e60\u795e\u7ecf\u7f51\u7edc\u975e\u5e38\u9002\u5408\u4ece\u5404\u79cd\u6570\u636e\u7c7b\u578b\uff08\u4f8b\u5982\uff0c\u4e0d\u540c\u836f\u7269\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u836f\u6548\u5b66\u6027\u8d28\uff0c\u6765\u81ea\u8fd9\u4e9b\u836f\u7269\u7684\u7ec6\u80de\u7b5b\u9009\u7684\u591a\u7ec4\u5b66\u6570\u636e\u7b49\uff09\u8fdb\u884c\u5b66\u4e60\uff0c\u4ee5\u4fbf\u66f4\u597d\u5730\u7406\u89e3\u548c\u9884\u6d4b\u836f\u7269\u7684\u8f93\u5165<\/span>\u2014<\/span>\u8f93\u51fa\u5173\u7cfb\uff08\u4f8b\u5982\uff0c\u5404\u79cd\u5316\u5b66\u5b9e\u4f53\u7684\u751f\u7269\u7269\u7406\u548c\u7ed3\u6784\u6027\u8d28\uff0c\u5b83\u4eec\u7684\u5206\u5b50\u9776\u6807\u4ee5\u53ca\u5b83\u4eec\u8bf1\u5bfc\u7684\u751f\u7269\u5b66\u53cd\u5e94\uff09\u3002<\/span>\u80f6\u56ca\u7f51\u7edc\u6a21\u578b\u53ef\u7528\u4e8e\u7814\u7a76\u590d\u6742\u75be\u75c5\uff0c\u9884\u6d4b\u51fa<\/span>\u6cbb\u7597\u75be\u75c5\u65f6\u53ef\u80fd\u9700\u8981<\/span>\u6291\u5236\u7684\u591a\u4e2a\u9776\u6807\u3002\u8fd9\u4e9b\u9884\u6d4b\u53ef\u4ee5\u88ab\u591a\u4efb\u52a1\u5b66\u4e60\u7528\u6765\u8bc6\u522b\u201c\u80ae\u810f\u201d\u7684\u5316\u5408\u7269\uff0c\u6216\u8005\u5bf9\u6b64\u7c7b\u5316\u5408\u7269\u8fdb\u884c\u7ec4\u5408\u4ee5\u66f4\u597d\u7684\u4f5c\u7528\u4e8e\u9776\u70b9\u3002\u56e0\u6b64\uff0c<\/span><\/span>\u6211\u4eec\u9884\u89c1\u591a\u4efb\u52a1\u5b66\u4e60\u4e0e\u5176\u4ed6\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u7ed3\u5408\u8d77\u6765\uff0c\u5c06\u6709\u52a9\u4e8e\u89e3\u51b3\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u751f\u7269\u548c\u5316\u5b66\u6570\u636e\u6574\u5408\u95ee\u9898\uff0c\u5e76\u521b\u5efa\u591a\u5c42\u9884\u6d4b\u7f51<\/span>\u7edc<\/span>\u6a21\u578b\uff0c\u63a8\u8fdb\u836f\u7269\u7684\u5408\u7406\u5316\u8bbe\u8ba1\u3002<\/span><\/strong><\/p>\n

\n

\"\u96c6\u667a\"<\/p>\n

\u56fe1.\u00a0\u6df1\u5ea6\u5b66\u4e60\u7684\u7ec4\u7ec7\u6784\u67b6\u5728\u836f\u7269\u5f00\u53d1\u9886\u57df\u5177\u6709\u5f88\u9ad8\u7684\u5e94\u7528\u4ef7\u503c\u3002<\/span><\/strong><\/p>\n

\n

\n

\n

\n
\n
\n

\u5fae\u751f\u7269\u7814\u7a76<\/strong><\/span><\/p>\n

 <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u4eba\u7c7b\u5fae\u751f\u7269\u7ec4\u5305\u62ec\u7ec6\u83cc\u3001\u53e4\u7ec6\u83cc\u3001\u75c5\u6bd2\u3001\u771f\u83cc\u3001\u539f\u751f\u52a8\u7269\u3002\u8fd9\u4e9b\u5fae\u751f\u7269\u751f\u6d3b\u5728\u4eba\u4f53\u8868\u9762\u6216\u4eba\u4f53\u5185\u3002<\/span> \u6bcf\u4e2a\u8eab\u4f53\u90e8\u4f4d\u7684\u5fae\u751f\u7269\u7684\u591a\u6837\u6027\u662f\u60ca\u4eba\u7684\uff0c\u73b0\u5728\u4eba\u4eec\u8ba4\u4e3a\u52a8\u6001\u4e14\u76f8\u4e92\u5173\u8054\u7684\u5fae\u751f\u7269\u7fa4\u7cfb\u7edf\u5728\u5065\u5eb7\u3001\u75be\u75c5\u548c\u53d1\u80b2\u4e2d\u8d77\u7740\u91cd\u8981\u7684\u4f5c\u7528\u3002<\/span> \u4eba\u7c7b\u5fae\u751f\u7269\u7fa4\u7684\u5b8f\u57fa\u56e0\u7ec4\u6570\u636e\u5927\u91cf\u6d8c\u73b0\uff0c\u4f46\u5c06\u8fd9\u4e9b\u6570\u636e\u53d8\u5f97\u66f4\u5177\u6709\u751f\u7269\u5b66\u548c\u4e34\u5e8a\u610f\u4e49\u4ecd\u7136\u662f\u4e00\u9879\u91cd\u5927\u6311\u6218\u3002<\/span> \u8fd9\u4e5f\u4e3a\u5229\u7528\u4e0b\u4e00\u4ee3\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u529b\u91cf\u7684\u7f51\u7edc\u751f\u7269\u5b66\u63d0\u4f9b\u4e86\u6781\u597d\u7684\u673a\u4f1a\u3002<\/span><\/span><\/p>\n

\u4e0d\u540c\u8eab\u4f53\u90e8\u4f4d\u7684\u5fae\u751f\u7269\u548c\u5bbf\u4e3b\u7ec6\u80de\u901a\u8fc7\u4ea7\u751f\u3001\u4ea4\u6362\u548c\u5229\u7528\u5c0f\u751f\u7269\u5206\u5b50\uff08\u4e3b\u8981\u662f\u4ee3\u8c22\u7269\uff09\u76f8\u4e92\u4f5c\u7528\u3002<\/span> \u8fd9\u4e9b\u76f8\u4e92\u4f5c\u7528\u4ea7\u751f\u4e86\u7ec6\u80de\u5185\u3001\u7ec6\u80de\u95f4\u3001\u7269\u79cd\u95f4\u548c\u8de8\u751f\u7269\u754c\u7684\u4ee3\u8c22\u7f51\u7edc\u3002<\/span> \u8fd9\u4e3a\u4efb\u4f55\u7ed9\u5b9a\u7684\u5fae\u751f\u7269\u7fa4\u2014\u5bbf\u4e3b\u7cfb\u7edf\u521b\u9020\u4e86\u57fa\u4e8e\u5171\u4eab\u4ee3\u8c22\u7269\u4ea7\u751f<\/span>\u5143\u4ee3\u8c22\u7f51\u7edc\u6a21\u578b\uff08Meta-metabolic network model\uff09<\/span>\u7684\u673a\u4f1a\u3002<\/span> \u8fd9\u4e9b\u6a21\u578b\u53ef\u7528\u4e8e\u7ed8\u5236\u3001\u5256\u6790\u548c\u7406\u89e3\u591a\u79cd\u5fae\u751f\u7269\u4e0e\u5bbf\u4e3b\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ee5\u53ca\u9884\u6d4b\u5bbf\u4e3b\u4e0e\u5176\u5bc4\u751f\u5fae\u751f\u7269\u4e4b\u95f4\u53ef\u80fd\u4ea7\u751f\u7684<\/span>\u534f\u540c\u4f5c\u7528\u548c\u751f\u7269\u8d28<\/span>\u5173\u7cfb\uff08Synergistic and dysbiotic relationship\uff09<\/span>\u3002<\/span><\/span><\/p>\n

\u76ee\u524d\u4e3a\u6b62\uff0c\u6211\u4eec\u5df2\u7ecf<\/span>\u4e3a\u8bb8\u591a\u5fae\u751f\u7269\u6a21\u5f0f\u751f\u7269\uff08\u4f8b\u5982\uff0c\u5927\u80a0\u6746\u83cc\uff09\u4ee5\u53ca\u4eba\u7c7b\u7ec6\u80de\u6784\u5efa\u4e86\u4ee3\u8c22\u7f51\u7edc\u6a21\u578b\u3002\u8fd9\u4e9b\u6a21\u578b\u63d0\u4f9b\u4e86\u4ee3\u8c22\u7269\u5982\u4f55\u901a\u8fc7\u751f\u7269\u5316\u5b66\u53cd\u5e94\u5728\u7ed9\u5b9a\u7ec6\u80de\u4e2d\u76f8\u4e92\u4f5c\u7528\u7684\u5168\u5c40\u56fe\uff0c\u6211\u4eec\u53ef\u4ee5\u5bf9\u5176\u8fdb\u884c\u5229\u7528\u3001\u4fee\u6539\u548c\u6574\u5408\uff0c\u521b\u5efa\u8de8\u8d8a\u591a\u79cd\u751f\u7269\u4f53\u6216\u7ec6\u80de\u7c7b\u578b\u7684<\/span>\u5143\u7f51\u7edc\uff08Meta-networks\uff09<\/span>\u3002\u4e0d\u5e78\u7684\u662f\uff0c\u7531\u4e8e\u6570\u636e\u7684\u7a00\u758f\u548c\u5fae\u751f\u7269\u7684\u6570\u636e\u6d4b\u5b9a\u65b9\u9762\u7684\u95ee\u9898\uff0c\u6211\u4eec\u5bf9\u8bb8\u591a\u5fae\u751f\u7269\u4e2d\u7684\u4ee3\u8c22\u7f51\u7edc\u7684\u7406\u89e3\u662f\u6709\u9650\u7684\u6216\u6839\u672c\u5c31\u4e0d\u5b58\u5728\u3002\u8fd9\u5bf9\u4e8e\u5143\u4ee3\u8c22\u7f51\u7edc\u6a21\u578b\u7684\u4ea7\u751f\u63d0\u51fa\u4e86\u91cd\u5927\u6311\u6218\u3002\u8fd9\u65b9\u9762\u7684\u95ee\u9898\u4e5f\u6709\u89e3\u51b3\u65b9\u6cd5\uff0c\u90a3\u5c31\u662f<\/span>\u8fc1\u79fb\u5b66\u4e60\uff08Transefer learning\uff09\u3002<\/span><\/span><\/p>\n

\u4e0e\u591a\u4efb\u52a1\u5b66\u4e60\u76f8\u6bd4\uff0c<\/span>\u8fc1\u79fb\u5b66\u4e60\u65e8\u5728\u4ece\u5b66\u4e60\u4e0d\u540c\u4f46\u76f8\u5173\u7684\u4efb\u52a1\u65f6\u83b7\u5f97\u7684\u77e5\u8bc6\u4e2d\u8fdb\u884c\u5b66\u4e60<\/span><\/span>\u3002\u4e0d\u540c\u7684\u751f\u7269\u7cfb\u7edf\u5177\u6709\u8bb8\u591a\u76f8\u4f3c\u7279\u5f81\uff0c\u8fd9\u8868\u660e\u5728\u4e00\u4e2a\u7cfb\u7edf\u4e2d\u751f\u6210\u7684\u6570\u636e\u53ef\u4ee5\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u5e94\u7528\u4e8e\u53e6\u4e00\u4e2a\u7cfb\u7edf\u3002\u6240\u4ee5\u8fd9\u6837\u4e00\u6765\uff0c\u771f\u6b63\u7684\u6311\u6218\u53d8\u6210\u4e86\u5982\u4f55\u6700\u597d\u5730\u5c06\u5728\u7ed9\u5b9a\u7cfb\u7edf\u4e2d\u5b66\u5230\u7684\u77e5\u8bc6\u5e94\u7528\u4e8e\u53ea\u5b58\u5728\u6709\u9650\u6570\u636e\u7684\u65b0\u578b\u7cfb\u7edf\u4e2d\u3002<\/span><\/p>\n

\u8fc1\u79fb<\/span>\u5b66\u4e60\u53ef\u4ee5\u6839\u636e\u5176\u4ed6\u7cfb\u7edf\u7684\u89c2\u5bdf\u7ed3\u679c\u5bf9\u65b0\u7cfb\u7edf\u8fdb\u884c\u63a8\u65ad\u548c\u9884\u6d4b\u3002<\/span><\/span><\/strong> \u5177\u4f53\u800c\u8a00\uff0c\u8fc1\u79fb\u5b66\u4e60\u4f7f\u4eba\u4eec\u80fd\u591f\u5c06\u7528\u4e8e\u5b66\u4e60\u7279\u5b9a\u4efb\u52a1\u7684\u6a21\u578b\u91cd\u65b0\u5b9a\u4f4d\u4e3a\u5b66\u4e60\u4e0d\u540c\u4f46\u76f8\u5173\u4efb\u52a1\u7684\u8d77\u70b9\u3002\u8fc1\u79fb\u5b66\u4e60<\/span>\u80cc\u540e\u7684\u6982\u5ff5\u5f88\u5bb9\u6613\u9002\u7528\u4e8e\u751f\u7269\u5b66\u4e2d\u7684\u95ee\u9898\u3002<\/span> \u4ee5\u4ee3\u8c22\u7f51\u7edc\u4e3a\u4f8b\u2014\u751f\u5316\u5316\u5408\u7269\u7684\u4e0d\u53d8\u6027\uff08\u5373\u5927\u80a0\u6746\u83cc\u4e2d\u7684<\/span>\u201c<\/span>\u8461\u8404\u7cd6<\/span>\u201d<\/span>\u4e0e\u70ad\u75bd\u6746\u83cc\u4e2d\u7684<\/span>\u201c<\/span>\u8461\u8404\u7cd6<\/span>\u201d\u4e3a<\/span>\u76f8\u540c\u7684\u6709\u673a\u5316\u5408\u7269\uff09\u4e3a\u77e5\u8bc6\u7684\u5f52\u7eb3\u8fc1\u79fb\u63d0\u4f9b\u4e86\u57fa\u7840\u3002<\/span> \u8fd9\u610f\u5473\u7740\u5728\u6a21\u5f0f\u751f\u7269\u4f53\u4e2d\u4f18\u5316\u7684\u673a\u5668\u5b66\u4e60\u6a21\u578b\u53ef\u4ee5\u91cd\u590d\u4f7f\u7528\u6216\u91cd\u65b0\u7528\u4e8e\u5728\u6570\u636e\u7a00\u7f3a\u7684\u4e0d\u540c\u751f\u7269\u4f53\u4e2d\u3002<\/span><\/span><\/p>\n

\u8fd9\u4e3a\u7814\u7a76\u5fae\u751f\u7269\u7fa4\u843d\u7684\u4ee3\u8c22\u590d\u6742\u6027\u5f00\u8f9f\u4e86\u4e00\u6761\u4ee4\u4eba\u5174\u594b\u7684\u9014\u5f84\uff0c\u5728\u8fd9\u91cc\u53ef\u4ee5<\/span>\u201c<\/span>\u8fc1\u79fb<\/span>\u201d<\/span>\u6216\u4f7f\u7528\u6765\u81ea\u7ecf\u8fc7\u6a21\u5f0f\u7269\u79cd\uff08\u5982\u5927\u80a0\u6746\u83cc\uff09\u7684\u4ee3\u8c22\u7f51\u7edc\u4e0a\u7684\u5b66\u4e60\u4fe1\u606f\uff0c\u5e94\u7528\u4e8e<\/span>\u672a\u88ab\u7814\u7a76\u7684\u7269\u79cd<\/span>\uff0c\u4ece\u800c\u52a0\u901f\u6211\u4eec\u5bf9\u5fae\u751f\u7269\u7fa4\u4f53\u4e2d\u591a\u79cd\u7269\u79cd\u7684\u7406\u89e3\u3002\u4e0e\u8fc1\u79fb\u5b66\u4e60\u7c7b\u4f3c\uff0c\u6211\u4eec\u53ef\u4ee5\u6982\u5ff5\u5316\u4e00\u79cd\u673a\u5668\u5b66\u4e60\u6a21\u578b\uff0c\u8fd9\u79cd\u6a21\u578b\u53ef\u4ee5\u5229\u7528\u5728\u8f83\u7b80\u5355\u7cfb\u7edf\u4e0a\u83b7\u5f97\u7684\u77e5\u8bc6\u6765\u7406\u89e3\u66f4\u590d\u6742\u7684\u7cfb\u7edf<\/strong>\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u5f0f\uff0c\u4eba\u4eec\u53ef\u4ee5\u5efa\u7acb\u5fae\u751f\u7269\u7fa4\u4e0e\u5bbf\u4e3b\u4e4b\u95f4\u7684\u4ee3\u8c22\u76f8\u4e92\u4f5c\u7528\u5173\u7cfb\u7684\u7efc\u5408\u6a21\u578b\u3002<\/span><\/span><\/p>\n

\u8fd9\u4e9b\u6a21\u578b\u53ef\u4ee5\u5728\u6a2a\u8de8\u5065\u5eb7\u548c\u75be\u75c5\u72b6\u6001\u7684\u751f\u7269\u6570\u636e\u96c6\u4e0a\u8fdb\u884c\u8bad\u7ec3\uff0c\u5e76\u7528\u4e8e\u9884\u6d4b\u7279\u5b9a\u7269\u79cd\u7684\u6d88\u5931\u3001\u5f15\u5165\u6216\u751f\u957f\u5982\u4f55\u7834\u574f\u6216\u589e\u5f3a\u751f\u6001\u7cfb\u7edf\u7684\u4ee3\u8c22\u5e73\u8861\uff0c\u6216\u8005\u6b64\u7269\u79cd\u662f\u5426\u4f1a\u4ea7\u751f\u4fc3\u8fdb\u5065\u5eb7\u7684\u6709\u76ca\u4ee3\u8c22\u7269\uff0c\u6216\u635f\u5bb3\u5bbf\u4e3b\u7ec4\u7ec7\u7684\u6bd2\u6027\u4ee3\u8c22\u526f\u4ea7\u7269\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u4e9b\u5148\u8fdb\u7684\u673a\u5668\u5b66\u4e60\u6280\u672f\u548c\u7f51\u7edc\u751f\u7269\u5b66\u65b9\u6cd5\u4e0d\u4e00\u5b9a\u9650\u4e8e\u4eba\u7c7b\u5065\u5eb7\u5e94\u7528\u2014\u5b83\u4eec\u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u6269\u5c55\u5230\u519c\u4e1a\u3001\u73af\u5883\u548c\u5de5\u4e1a\u73af\u5883\u4e2d\u7684\u5fae\u751f\u7269\u7fa4\u7814\u7a76\u4e2d\u3002<\/span><\/p>\n

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\u5408\u6210\u751f\u7269\u5b66<\/strong><\/span><\/p>\n

 <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\n

\"\u96c6\u667a\"<\/p>\n

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\n

\n

\n

\n
\n
\n

\u6311\u6218\u4e0e\u5c55\u671b<\/strong><\/span><\/p>\n

 <\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n<\/section>\n

\u4ece\u4e0a\u9762\u7684\u8ba8\u8bba\u4e2d\u6211\u4eec\u53ef\u4ee5\u6e05\u695a\u5730\u770b\u51fa\uff0c\u7f51\u7edc\u751f\u7269\u5b66\u4e0e\u4e0b\u4e00\u4ee3\u673a\u5668\u5b66\u4e60\u7684\u4ea4\u53c9\u7814\u7a76\u62e5\u6709\u7740\u5de8\u5927\u7684\u673a\u9047\u3002<\/span> \u4f46\u662f\uff0c\u8fd8\u6709\u5f88\u591a\u8270\u96be\u7684\u6311\u6218\u9700\u8981\u6211\u4eec\u5ba2\u670d\u3002<\/span>\u00a0<\/span>\u5176\u4e2d<\/span>\u6700\u5173\u952e\u4e5f\u6700\u91cd\u8981\u7684\u662f\u5927\u578b\u6570\u636e\u96c6\u3002<\/span><\/strong> \u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u548c\u5176\u4ed6\u4e0b\u4e00\u4ee3\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u5bf9\u4e8e\u6570\u636e\u662f\u53ca\u5176\u9965\u6e34\u7684\u3002<\/span> \u6211\u4eec\u751f\u6d3b\u5728\u751f\u7269\u5b66\u548c\u533b\u5b66\u7684\u5927\u6570\u636e\u65f6\u4ee3\uff0c\u6211\u4eec\u5728\u751f\u7269\u7684\u4e0d\u540c\u5c42\u6b21\u6536\u96c6\u5927\u91cf\u7684\u6570\u636e\u96c6\u3002<\/span>\u00a0\u5c3d\u7ba1<\/span>\u4ece\u751f\u7269\u7cfb\u7edf\u83b7\u53d6\u7684\u6570\u636e\u53ef\u80fd\u975e\u5e38\u590d\u6742\uff0c\u53cd\u5e94\u751f\u7269\u7cfb\u7edf\u7684\u4e0d\u540c\u65b9\u9762\u7684\u53d8\u91cf\u53ef\u80fd\u5305\u542b\u6709\u6570\u5343\u4e2a\uff0c\u4f46\u662f\uff0c\u5927\u591a\u6570\u751f\u7269\u6570\u636e\u96c6\u7684\u6570\u91cf\u7ea7\u4ecd\u7136\u592a\u5c0f\uff0c\u65e0\u6cd5\u6df1\u5ea6\u5b66\u4e60\u7b97\u6cd5\u7684\u8981\u6c42\u3002<\/strong><\/span><\/span><\/p>\n

\u5f53\u7136\uff0c\u6211\u4eec<\/span>\u6709\u5f88\u591a\u9009\u62e9\u6765\u5e94\u5bf9\u8fd9\u4e00\u6311\u6218\u3002\u9996\u5148\u662f\u6536\u96c6\u5927\u578b\u4e14\u6ce8\u91ca\u826f\u597d\u7684\u6570\u636e\u96c6<\/strong>\u3002\u591a\u7ec4\u5b66\u6570\u636e\u96c6\u53ef\u80fd\u8fc7\u4e8e\u6602\u8d35\uff0c\u56e0\u6b64\u6211\u4eec\u53ef\u4ee5\u8003\u8651\u66ff\u4ee3\u65b9\u6848\u6765\u8865\u5145\u6216\u8865\u8db3\u8fd9\u4e9b\u6570\u636e\u3002\u7531\u4e8e\u8bb8\u591a\u6df1\u5ea6\u5b66\u4e60\u7b97\u6cd5\u5df2\u7ecf\u6210\u529f\u5730\u5e94\u7528\u4e8e\u8bca\u65ad\u80cc\u666f\u4e0b\u7684\u6210\u50cf\u6570\u636e\uff0c\u6240\u4ee5\u589e\u52a0\u5229\u7528\u6210\u50cf\u6570\u636e\uff08\u5305\u62ec\u89c6\u9891\uff09\u6765\u8868\u5f81\u7ec6\u80de\u7684\u5f62\u6001\u6216\u8868\u578b\u53d8\u5316\uff08\u4f8b\u5982\u54cd\u5e94\u836f\u7269\u6cbb\u7597\uff09\u5c06\u4f1a\u4e00\u79cd\u4e0d\u9519\u7684\u9009\u62e9\u3002\u6211\u4eec\u53ef\u4ee5\u901a\u8fc7\u5efa\u7acb\u5177\u6709\u8367\u5149\u6216\u6bd4\u8272\u8bfb\u6570\u7684\u7ec6\u80de\u7cfb\u6765\u6765\u8868\u5f81\u5404\u79cd\u6cbb\u7597\u65b9\u6cd5\u6216\u73af\u5883\u6270\u52a8\u4e0b\u7684\u7ec6\u80de\u53cd\u5e94\u3002\u8bb8\u591a\u751f\u7269\u6570\u636e\u96c6\u5c0f\u800c\u7a00\u758f\u7684\u7279\u6027\u4e5f\u7ed9\u673a\u5668\u5b66\u4e60\u7814\u7a76\u4eba\u5458\u5e26\u6765\u4e86\u4e00\u4e2a\u6709\u8da3\u7684\u6311\u6218\u2014\u5373\u4e13\u95e8\u8bbe\u8ba1\u6765\u5904\u7406\u6b64\u7c7b\u6570\u636e\u96c6\u7684\u65b0\u4e00\u4ee3\u6df1\u5ea6\u5b66\u4e60\u7b97\u6cd5\u3002<\/span><\/span><\/p>\n

\u53e6\u4e00\u79cd\u53ef\u80fd\u7684\u9009\u62e9\u662f\u751f\u6210\u5177\u6709\u5b9e\u9645\u6570\u636e\u5c5e\u6027\u7684\u8ba1\u7b97\u673a\u6570\u636e\u3002<\/span><\/strong>\u5bf9\u4e8e\u6df1\u5ea6\u5b66\u4e60\u80cc\u666f\u4e0b\u7684\u56fe\u50cf\u5206\u6790\uff0c\u7814\u7a76\u4eba\u5458\u901a\u5e38\u4f7f\u7528<\/span>\u751f\u6210\u5bf9\u6297\u7f51\u7edc\uff08Generative adversarial networks,\u00a0<\/span>GAN<\/span>\uff09<\/span>\u6765\u5b8c\u6210\uff0c\u8be5\u65b9\u6cd5\u53ef\u4ee5\u521b\u5efa\u4e0e\u8bad\u7ec3\u6570\u636e\u7c7b\u4f3c\u7684\u6570\u636e\u96c6\u3002<\/span> GAN<\/span>\u662f\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc\u67b6\u6784\uff0c\u7531\u4e24\u4e2a\u4e92\u76f8\u5bf9\u7acb\u7684\u795e\u7ecf\u7f51\u7edc\u7ec4\u6210<\/span>\u2014<\/span>\u4e00\u4e2a\u662f\u751f\u6210\u6a21\u578b\uff08Generative model\uff09\uff0c\u7528\u4e8e\u4ea7\u751f\u4e0e\u8bad\u7ec3\u6570\u636e\u96c6\u5206\u5e03\u76f8\u4f3c\u7684\u65b0\u6570\u636e\uff0c\u53e6\u4e00\u4e2a\u662f\u533a\u5206\u6a21\u578b\uff08Discriminative model\uff09\uff0c\u5373\u5bf9\u624b\uff0c\u7528\u4e8e\u8bc4\u4f30\u65b0\u6570\u636e\u5e76\u786e\u5b9a\u5b83\u662f\u5426\u5c5e\u4e8e\u5b9e\u9645\u7684\u8bad\u7ec3\u6570\u636e\u96c6\u3002<\/span><\/span><\/p>\n

\u4e24\u4e2a\u795e\u7ecf\u7f51\u7edc\u4e4b\u95f4\u7684\u7ade\u4e89\u4f1a\u9010\u6e10\u7684\u6539\u8fdb\u7b97\u6cd5\uff0c\u76f4\u5230\u751f\u6210\u7684\u6570\u636e\u96c6\u4e0e\u8bad\u7ec3\u6570\u636e\u96c6\u65e0\u6cd5\u533a\u5206\u4e3a\u6b62\u3002<\/span>\u8fd9\u79cd\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u5728\u7f51\u7edc\u751f\u7269\u5b66\u7684\u591a\u7ec4\u5b66\u6570\u636e\u96c6\u627e\u5230\u5e94\u7528\u7684\u4ef7\u503c\u3002\u4e00\u4e2a\u7b80\u5355\u7684\u4f8b\u5b50\u5c31\u662f\u4f7f\u7528<\/span>GAN<\/span>\u751f\u6210\u66f4\u5927\u7684\u57fa\u56e0\u8868\u8fbe\u6570\u636e\u96c6\uff0c\u8fd9\u4e9b\u6570\u636e\u96c6\u5c06\u6709\u52a9\u4e8e\u751f\u6210\u8f6c\u5f55\u8c03\u63a7\u7684\u9884\u6d4b\u6a21\u578b\u3002<\/span><\/span><\/p>\n

\u5927\u591a\u6570\u4e0b\u4e00\u4ee3\u673a\u5668\u5b66\u4e60\u6a21\u578b\u7684<\/span>\u201c<\/span>\u9ed1\u7bb1<\/span>\u201d<\/span>\u6027\u8d28\u4e3a\u751f\u7269\u5e94\u7528\u5e26\u6765\u4e86\u65b0\u7684\u6311\u6218\u3002<\/span>\u4ece\u751f\u7269\u5b66\u7684\u89d2\u5ea6\u6765\u89e3\u91ca\u7ed9\u5b9a\u6a21\u578b\u7684\u8f93\u51fa\u901a\u5e38\u662f\u975e\u5e38\u56f0\u96be\u7684\uff0c\u4ece\u800c\u9650\u5236\u4e86\u8be5\u6a21\u578b\u5728\u751f\u7269\u673a\u5236\u548c\u7f51\u7edc\u67b6\u6784\u5206\u6790\u4e2d\u7684\u6548\u679c\u3002\u5f53\u7136\uff0c<\/span>\u60c5\u51b5\u5e76\u975e\u603b\u662f\u5982\u6b64\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u66f4\u7b80\u5355\u7684\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u3002\u4f8b\u5982\uff0c\u7a00\u758f\u7ebf\u6027\u56de\u5f52\u6a21\u578b\uff08Sparse linear regression model\uff0c\u6bd4\u5982elastic net, lasso and ridge regression<\/span>\uff09\u53ef\u4ee5\u7528\u6765\u5b66\u4e60<\/span>\u6bcf\u4e2a\u7279\u5f81\u76f8\u5bf9\u6743\u91cd\u7684\u6700\u4f73\u7cfb\u6570\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u6a21\u578b\u7cfb\u6570\u53ef\u4ee5\u544a\u77e5\u7814\u7a76\u4eba\u5458\u6a21\u578b\u4e2d\u6bcf\u4e2a\u7279\u5f81\u7684\u76f8\u5bf9<\/span>\u201c<\/span>\u91cd\u8981\u6027<\/span>\u201d<\/span>\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u66f4\u5148\u8fdb\u7684\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\uff0c\u4f8b\u5982\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc\uff0c\u8bad\u7ec3\u8fc7\u7a0b\u5bf9\u8f93\u5165\u6570\u636e\u7684\u5904\u7406\u65b9\u5f0f\u4f7f\u5f97\u6211\u4eec\u96be\u4ee5\u786e\u5b9a\u7279\u5f81\u7684\u76f8\u5bf9\u91cd\u8981\u6027\u6216\u7279\u5f81\u662f\u5426\u4e0e\u8f93\u51fa\u7ed3\u679c\u5b58\u5728\u6b63\u76f8\u5173\u6216\u8d1f\u76f8\u5173\u3002<\/span>\u6211\u4eec\u8feb\u5207\u9700\u8981\u5f00\u53d1\u51fa\u4e00\u79cd\u624b\u6bb5\uff0c\u5c06\u6df1\u5ea6\u5b66\u4e60\u7684<\/span>\u201c<\/span>\u9ed1\u7bb1<\/span>\u201d<\/span>\u8f6c\u53d8\u4e3a\u5728\u751f\u7269\u5b66\u89d2\u5ea6\u5bcc\u6709\u610f\u4e49\u4e14\u53ef\u89e3\u91ca\u7684<\/span>\u201c<\/span>\u767d\u7bb1<\/span>\u201d<\/span>\u3002<\/span><\/strong><\/span><\/p>\n

\u5728\u63ed\u793a\u548c<\/span>\u5229\u7528\u751f\u7269\u590d\u6742\u7f51\u7edc\u7684\u65b9\u5411\u6211\u4eec\u8fd8\u6709\u5f88\u957f\u7684\u8def\u8981\u8d70 \uff0c\u673a\u5668\u5b66\u4e60\u672c\u8eab\u8fd8\u8fdc\u672a\u5b9e\u73b0\u5176\u5728\u751f\u7269\u7814\u7a76\u9886\u57df\u7684\u6f5c\u529b\u3002<\/span> \u5c3d\u7ba1\u5982\u6b64\uff0c\u5229\u7528\u673a\u5668\u5b66\u4e60\u66f4\u597d\u7684\u7406\u89e3\u590d\u6742\u751f\u7269\u7f51\u7edc\u7684\u9886\u57df\u7684\u53d1\u5c55\u8ba9\u7f51\u7edc\u751f\u7269\u5b66\u7814\u7a76\u53ef\u4ee5\u62e5\u6709\u4e00\u4e2a\u4ee4\u4eba\u6fc0\u52a8\u7684\u672a\u6765\u3002<\/span><\/span><\/p>\n

\u53c2\u8003\u6587\u732e<\/span><\/strong><\/p>\n

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2018\u5e7412\u670831\u65e5\uff0c\u96c6\u667a\u4ff1\u4e50\u90e8\uff08Swarma Club\uff09\u5c06\u8054\u5408\u591a\u5bb6\u79d1\u6280\u3001\u5b66\u672f\u7ec4\u7ec7\uff0c\u5728\u5317\u4eac\u4e3e\u529e\u4e00\u5e74\u4e00\u5ea6\u7684\u5b66\u672f\u665a\u4f1a\u3002<\/span>\u672c\u5c4a\u665a\u4f1a\u7684\u4e3b\u9898\u662f\u201c\u5947\u70b9\u4e34\u8fd1\u201d\uff08The Singularity is Near\uff09<\/strong>\u3002<\/span><\/a><\/p>\n

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\u5546\u52a1\u5408\u4f5c\u53ca\u6295\u7a3f\u8f6c\u8f7d\uff5cswarma@swarma.org
\n<\/span><\/strong><\/p>\n

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\u8ba9\u82f9\u679c\u7838\u5f97\u66f4\u731b\u70c8\u4e9b\u5427\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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