{"id":14399,"date":"2019-01-15T00:00:50","date_gmt":"2019-01-14T16:00:50","guid":{"rendered":"http:\/\/swarma.org\/094cae261a\/"},"modified":"2019-01-23T10:43:39","modified_gmt":"2019-01-23T02:43:39","slug":"094cae261a","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=14399","title":{"rendered":"Nature\u91cd\u78c5\uff1a\u7528\u6d3b\u7ec6\u80de\u642d\u5efa\u903b\u8f91\u7535\u8def\u2014\u2014\u8c03\u63a7\u7ec6\u80de\u529f\u80fd\u7684\u8de8\u5b66\u79d1\u4e4b\u65c5"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><img class=\"\" style=\"width: 100%;height: auto\" src=\"http:\/\/swarma.org\/wp-content\/uploads\/2019\/01\/swarma4-1547557233.jpg\" alt=\"\u96c6\u667a\" title=\"\u96c6\u667a\" \/><\/p>\n<p style=\"text-align: center;margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span style=\"font-size: 13px\"><strong>\u5236\u4f5c\uff1aDavid Parkins<\/strong><\/span><span><\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\">\n<section class=\"\" style=\"letter-spacing: 0.544px\">\n<p><span><strong><span>\u5bfc\u8bed<\/span><\/strong><\/span><\/p>\n<section>\n<section>\n<section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em\"><span>\u968f\u7740\u751f\u7269\u6280\u672f\u7684\u9010\u65e5\u53d1\u5c55\uff0c\u8de8\u5b66\u79d1\u5728\u64cd\u63a7\u7ec6\u80de\u529f\u80fd\u65b9\u9762\u8d77\u7740\u65e0\u4e0e\u4f26\u6bd4\u7684\u4f5c\u7528\u3002\u7ec6\u80de\u5de5\u7a0b\u5e08\u5c06\u9762\u4e34\u7740\u524d\u6240\u672a\u6709\u7684\u6311\u6218\uff0c\u8fd9\u6311\u6218\u4e5f\u8bb8\u662f\u5212\u65f6\u7a7a\uff0c\u56e0\u4e3a\u8fd9\u538b\u529b\u4e0d\u4ec5\u662f\u6280\u672f\u4e0a\u7684\u96be\u9898\uff0c\u66f4\u591a\u7684\u662f\u4f26\u7406\u653f\u7b56\u4e0a\u7684\u77db\u76fe\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em\">\n<blockquote>\n<p style=\"text-align: left;margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>\u7f16\u8bd1\uff1a\u96c6\u667a\u4ff1\u4e50\u90e8\u7ffb\u8bd1\u7ec4<\/span><\/p>\n<p style=\"text-align: left;margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>\u6765\u6e90\uff1aNature<\/span><\/p>\n<p style=\"text-align: left;margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>\u539f\u9898\uff1a<\/span><\/p>\n<p style=\"text-align: left;margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>Computer logic meets cell biology: h\ufeffow cell science is getting an upgrade<\/span><\/p>\n<\/blockquote>\n<p class=\"ql-long-16599236\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>Yvonne Chen \u662f\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u7684\u4e00\u4f4d\u5316\u5b66\u4e0e\u751f\u7269\u5206\u5b50\u7684\u5de5\u7a0b\u5e08\uff0c\u5979\u7528\u4e00\u79cd\u79f0\u4e3a\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08chimaeric antigen receptors\uff0cCARs\uff09\u7684\u5408\u6210\u86cb\u767d\u4fee\u6539T\u6dcb\u5df4\u7ec6\u80de\uff08T lymphocyte\uff09\uff0c\u4f7f\u5176\u53ef\u4ee5\u627e\u5230\u4e24\u4e2a\u6297\u539f \u2014\u2014 CD19 \u548c CD20\u3002<strong>\u8fd9\u4e2a\u7814\u7a76\u53d1\u73b0\uff0c\u5982\u679c\u67d0\u4e2a\u764c\u7ec6\u80de\u5728\u514d\u75ab\u7cfb\u7edf\u7684\u653b\u51fb\u4e2d\u53d1\u751f\u4e86\u7a81\u53d8\uff0c\u4ee5\u81f3\u4e8eT\u7ec6\u80de\u5df2\u7ecf\u65e0\u6cd5\u8ba4\u51fa\u5176\u4e2d\u4e00\u4e2a\u6297\u539f\u4e86\uff0cT\u7ec6\u80de\u4ecd\u7136\u80fd\u591f\u5229\u7528\u53e6\u5916\u4e00\u4e2a\u6297\u539f\u627e\u5230\u5e76\u6740\u6b7b\u764c\u7ec6\u80de\u3002<\/strong><\/span><\/p>\n<\/p>\n<blockquote>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>\u6297\u539f\uff1a\u523a\u6fc0\u514d\u75ab\u7cfb\u7edf\uff0c\u5f15\u8d77\u6297\u4f53\u751f\u6210\u7684\u5206\u5b50\u3002<\/span><\/p>\n<\/blockquote>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span><\/span><\/p>\n<p style=\"text-align: center;margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span><strong><img class=\"\" src=\"http:\/\/swarma.org\/wp-content\/uploads\/2019\/01\/swarma4-1547557234-1.jpg\" alt=\"\u96c6\u667a\" title=\"\u96c6\u667a\" \/><\/strong><\/span><\/p>\n<p style=\"text-align: center;margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span><strong>\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821 \u5206\u5b50\u751f\u7269\u5b66\u7814\u7a76\u6240 \u5316\u5b66\u4e0e\u751f\u7269\u5206\u5b50\u5de5\u7a0b\u52a9\u7406\u6559\u6388 Yvonne Chen | \u6765\u6e90\uff1aUCLA Broad Stem Cell Research Center<\/strong><\/span><\/p>\n<\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>\u4f46\u662f Yvonne \u5e76\u6ca1\u6709\u7528\u4f20\u7edf\u7684\u751f\u7269\u672f\u8bed\u6765\u6982\u62ec\u81ea\u5df1\u7684\u53d1\u73b0\u3002\u5728\u5979\u770b\u6765\uff0c\u8fd9\u79cd\u53cc\u7279\u5f02\u6027\u6297\u4f53\u53ef\u4ee5\u8bc6\u522b\u4e24\u4e2a\u76ee\u6807\uff0c<strong>\u7528\u8ba1\u7b97\u673a\u672f\u8bed\u2014\u2014\u201c\u6216\u201d\u95e8\uff08OR-gate\uff09\u5c06\u5176\u547d\u540d\u4e3a\u201c\u6216\u201d\u95e8\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\uff08OR-gate CAR\uff09<\/strong>\u518d\u5408\u9002\u4e0d\u8fc7\u4e86\u3002<\/span><\/p>\n<\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>\u201c\u6216\u201d\u95e8\u8fd9\u4e2a\u672f\u8bed\u5c5e\u4e8e\u8ba1\u7b97\u673a\u79d1\u5b66\u9886\u57df\uff0c\u6307\u7684\u662f\uff1a\u5f53\u6709\u4efb\u610f\u4e24\u4e2a\u8f93\u5165\u9879\u65f6\uff0c\u53ef\u89e6\u53d1\u4e00\u4e2a\u903b\u8f91\u64cd\u4f5c\u3002\u7528\u5b83\u6765\u547d\u540d\uff0c\u4e0d\u4ec5\u53ea\u7528\u4e86\u4e24\u4e2a\u5b57\u4fbf\u63cf\u8ff0\u4e86\u7ec6\u80de\u7684\u5de5\u4f5c\uff0c\u4e5f\u53ef\u4ee5\u548c\u5176\u4ed6\u7c7b\u578b\u7684\u53cc\u7279\u5f02\u6027\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\u533a\u5206\u5f00\u6765\u3002<\/span><\/p>\n<\/p>\n<blockquote>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff1a\u53ef\u4ee5\u8bc6\u522b2\u79cd\u6297\u539f\u7684\u4eba\u5de5\u6297\u4f53\uff0c\u80fd\u591f\u6fc0\u53d1\u5bf9\u764c\u7ec6\u80de\u7684\u514d\u75ab\u53cd\u5e94\u3002<\/span><\/p>\n<\/blockquote>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>\u4f46\u662f\u5f53 Yvonne \u60f3\u8981\u53d1\u8868\u8fd9\u7bc7\u8bba\u6587\u65f6\uff0c\u5374\u906d\u5230\u4e86\u90e8\u5206\u540c\u4e8b\u4eec\u7684\u4e00\u81f4\u53cd\u5bf9\uff0c\u4ed6\u4eec\u8ba4\u4e3a\u751f\u7269\u7684\u7814\u7a76\u6210\u679c\u4e0d\u5e94\u4ee5\u8ba1\u7b97\u673a\u903b\u8f91\u8bed\u8a00\u6765\u547d\u540d\u3002\u7136\u800c\u5014\u5f3a\u7684\u5979\u8fd8\u662f\u4e00\u610f\u5b64\u884c\uff0c\u201c\u6211\u786e\u5b9e\u542c\u5230\u5f88\u591a\u4eba\u8bf4\u7528\u2018\u6216\u2019\u95e8\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\uff08OR-gate CAR\uff09\u4f1a\u8ba9\u7814\u7a76T\u7ec6\u80de\u7684\u4eba\uff0c\u65e0\u8bba\u662f\u7269\u7406\u5b66\u5bb6\u8fd8\u662f\u751f\u7269\u5b66\u5bb6\uff0c\u90fd\u4e0d\u77e5\u6240\u4e91\u3002\u73b0\u5728\u5927\u5bb6\u5374\u90fd\u8fd9\u4e48\u53eb\u4e86\uff0c\u56e0\u4e3a\u8fd9\u4e48\u53eb\u53cd\u800c\u66f4\u6e05\u6670\u660e\u4e86\u3002\u201d<\/span><\/p>\n<\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>Yvonne \u8bf4\uff0c\u201c\u6216\u201d\u95e8\u7ec6\u80de\u7814\u7a76\u5df2\u7ecf\u53ef\u4ee5\u5f00\u59cb\u4e34\u5e8a\u8bd5\u9a8c\u4e86\uff0c\u5979\u7684\u5b9e\u9a8c\u5ba4\u4e5f\u5728\u57f9\u80b2\u7ec6\u80de\u6a21\u4eff\u5176\u4ed6\u903b\u8f91\u6027\u529f\u80fd\uff0c\u4f8b\u5982\u201c\u4e0e\u201d\u95e8\uff08AND-gate\uff09\u2014\u2014\u53ea\u6709\u5f53\u4e24\u4e2a\u86cb\u767d\u8d28\u90fd\u6b63\u786e\u65f6\u624d\u53ef\u4ee5\u6267\u884c\u64cd\u4f5c\uff0c\u548c\u201c\u975e\u201d\u95e8\uff08NOT-gate\uff09\u2014\u2014\u5f53\u86cb\u767d\u8d28\u662f\u6b63\u786e\u65f6\u5f97\u5230\u4e00\u4e2a\u5426\u5b9a\u7684\u7ed3\u679c\u3002<\/span><\/p>\n<section class=\"mpa-template\">\n<section>\n<section>\n<section><strong><\/p>\n<p><span style=\"font-size: 16px\"><strong>\u57fa\u56e0\u7f16\u8f91\u7684\u8ba1\u7b97\u673a\u7ec6\u80de<\/strong><\/span><\/p>\n<p><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><strong><span>\u5728\u91cd\u65b0\u8bbe\u8ba1\u7ec6\u80de\u4ee5\u83b7\u5f97\u65b0\u7684\u7528\u9014\u7684\u65f6\u5019\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u751f\u7269\u7814\u7a76\u5ba4\u91c7\u7528\u8ba1\u7b97\u673a\u79d1\u5b66\u4e0e\u8ba1\u7b97\u673a\u5de5\u7a0b\u7684\u672f\u8bed\u548c\u6982\u5ff5\u6765\u5b9a\u4e49\u65b0\u7684\u7814\u7a76\u7ed3\u679c\u3002<\/span><\/strong><span>\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u9057\u4f20\u7f16\u8f91\u5de5\u5177\uff0c\u80fd\u591f\u5f97\u5230\u524d\u6240\u672a\u6709\u7684\u7ec6\u80de\u529f\u80fd\uff0c\u6709\u4e9b DNA \u7f16\u8f91\u6280\u672f\u5df2\u7ecf\u5b58\u5728\u4e86\u8bb8\u4e45\uff0c\u4f8b\u5982\u5229\u7528\u75c5\u6bd2\u6216\u8005\u86cb\u767d\u8d28\u8fdb\u884c\u7f16\u8f91\u7684\u950c\u6307\u6838\u9178\u9176\u6280\u672f\uff08zinc fingers\uff09\uff0c\u8fd8\u6709\u6700\u8fd1\u7684 CRISPR\u2013Cas9 \u6280\u672f\uff0c\u80fd\u591f\u66f4\u52a0\u7cbe\u51c6\u5730\u7f16\u8f91 DNA \u3002<\/span><\/p>\n<\/p>\n<blockquote>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>CRISPR\u2013Cas9<\/span><span>\uff1a\u4e00\u79cd\u57fa\u56e0\u7f16\u8f91\u6280\u672f\uff0c\u6a21\u62df\u7ec6\u83cc\u7279\u6709\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u5b9a\u5411\u5bfb\u627e\u3001\u5207\u9664\u86cb\u767d Cas9 \u4e2d\u5916\u6765\u75c5\u6bd2\u7684\u5165\u4fb5\u57fa\u56e0\u3002<\/span><\/p>\n<\/blockquote>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><strong><span>Yvonne \u53d1\u660e\u7684 \u201c\u6216\u201d\u95e8<span><span>\u5d4c\u5408\u6297\u539f\u53d7\u4f53\u7597\u6cd5<\/span><\/span><span><span><\/span><\/span>\u53ef\u4ee5\u627e\u5230\u201c\u9690\u8eab\u201d\u7684\u80bf\u7624<\/span><\/strong><span>\uff0c\u5f53\u764c\u7ec6\u80de\u65e0\u6cd5\u8bc6\u522b\u65f6\uff0c\u53ef\u4ee5\u901a\u8fc7\u514d\u75ab\u6cbb\u7597\u627e\u5230\u5e76\u653b\u51fb\u764c\u7ec6\u80de\u3002\u6709\u4e86\u5979\u7684T\u7ec6\u80de\uff0c\u764c\u7ec6\u80de\u5fc5\u987b\u5931\u53bb\u4e24\u4e2a\u6297\u539f\u624d\u80fd\u5b8c\u5168\u9690\u533f\u5728\u514d\u75ab\u7cfb\u7edf\u9762\u524d\uff0c\u4f46\u662f\u60f3\u8981\u764c\u7ec6\u80de\u5b8c\u5168\u5931\u53bb\u4e24\u4e2a\u6297\u539f\u51e0\u4e4e\u662f\u4e0d\u53ef\u80fd\u7684\u3002<\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>\u8fd9\u4e5f\u7ed9\u5979\u7684\u7597\u6cd5\u5e26\u6765\u53e6\u4e00\u4e2a\u68d8\u624b\u7684\u95ee\u9898\uff0c\u90a3\u5c31\u662f\u5f53\u8bc6\u522b\u4e00\u79cd\u7279\u5b9a\u7684\u764c\u7ec6\u80de\u65f6\uff0c\u4e5f\u4f1a\u540c\u65f6\u8bc6\u522b\u6709\u540c\u6837\u6297\u539f\u7684\u5065\u5eb7\u7ec6\u80de\u8fdb\u884c\u653b\u51fb\u3002<\/span><strong><span>\u56e0\u6b64\uff0cYvonne \u8bbe\u8ba1\u4e86\u53e6\u4e00\u79cd\u7684T\u7ec6\u80de\u4f5c\u4e3a\u751f\u7269\u5b66\u91cc\u7684\u201c\u4e0e\u201d\u95e8\u3002<\/span><\/strong><span>\u5728\u8fd9\u4e2a\u7cfb\u7edf\u91cc\uff0c\u5f53T\u7ec6\u80de\u5f97\u5230\u76ee\u6807\u6297\u539f\u7684\u4fe1\u53f7\u65f6\uff0c\u4f1a\u8868\u8fbe\u7b2c\u4e8c\u4e2a\u53d7\u4f53\uff0c\u53ea\u6709\u5f53\u7b2c\u4e8c\u4e2a\u53d7\u4f53\u4e5f\u83b7\u5f97\u81ea\u8eab\u5bf9\u5e94\u7684\u6297\u539f\u65f6\uff0cT\u7ec6\u80de\u624d\u80fd\u88ab\u6fc0\u6d3b\u5e76\u653b\u51fb\u764c\u7ec6\u80de\u3002\u81f3\u4e8eT\u7ec6\u80de\u8981\u7528\u201c\u4e0e\u201d\u95e8\u8fd8\u662f\u201c\u6216\u201d\u95e8\u8fdb\u884c\u6cbb\u7597\uff0c\u5e94\u8be5\u53d6\u51b3\u4e8e\u4e0d\u540c\u764c\u7ec6\u80de\u7684\u7279\u5f81\u3002<\/span><\/p>\n<\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>\u79d1\u5b66\u5bb6\u4e00\u6b21\u4e00\u4e2a\u3001\u4ee5\u5404\u79cd\u7ec4\u5408\u65b9\u5f0f\u8c03\u6574\u590d\u5236 DNA \u7684\u8f6c\u5f55\u56e0\u5b50\uff0c\u521b\u5efa\u5927\u91cf\u6570\u636e\uff0c\u4ee5\u4e86\u89e3\u6bcf\u79cd\u4e0d\u540c\u7684\u7ec4\u5408\u5982\u4f55\u6539\u53d8\u7ec6\u80de\u529f\u80fd\u3002\u4e0d\u8fc7\uff0c\u8fc7\u591a\u7684\u6570\u636e\u663e\u5f97\u975e\u5e38\u590d\u6742\u591a\u6837\uff0c\u9700\u8981\u4f1a\u5efa\u6a21\u7684\u8ba1\u7b97\u673a\u5b66\u5bb6\u6765\u9884\u6d4b\u6700\u540e\u7684\u7ed3\u679c\u3002<\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>\u8fd8\u6709\u7684\u7814\u7a76\u4eba\u5458\u6b63\u5728\u7814\u7a76\u5176\u4ed6\u6cbb\u7597\u65b9\u6cd5\uff0c\u6709\u4e00\u4e9b\u662f\u57fa\u4e8e\u60a3\u8005\u81ea\u8eab\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u4ece\u5206\u5316\u57f9\u517b\u7684\u89d2\u5ea6\u91cd\u65b0\u770b\u80da\u80ce\u53d1\u80b2\u7684\u7814\u7a76\u3002\u4ed6\u4eec\u76f8\u4fe1\u603b\u6709\u4e00\u5929\uff0c\u4eba\u4eec\u53ef\u80fd\u4f1a\u521b\u9020\u51fa\u73b0\u5728\u96be\u4ee5\u7f6e\u4fe1\u7684\u4ea7\u54c1\uff0c\u52a0\u5dde\u65af\u5766\u798f\u5927\u5b66\u751f\u7269\u5de5\u7a0b\u5e08 Drew Endy \u751a\u81f3\u8bf4\uff0c\u4eba\u7c7b\u662f\u201c\u9020\u7269\u4e3b\u201d\u3002<\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span><\/span><\/p>\n<p style=\"text-align: center;margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span style=\"font-size: 13px\"><strong><img class=\"\" style=\"width: 100%;height: auto\" src=\"http:\/\/swarma.org\/wp-content\/uploads\/2019\/01\/swarma1-1547557234.jpg\" alt=\"\u96c6\u667a\" title=\"\u96c6\u667a\" \/><\/strong><\/span><\/p>\n<p style=\"text-align: center;margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span><strong>\u65af\u5766\u798f\u5927\u5b66\u5408\u6210\u751f\u7269\u5b66\u5bb6\u3001\u751f\u7269\u5de5\u7a0b\u7ec8\u8eab\u6559\u6388 Drew Endy | \u6765\u6e90\uff1aWikipedia<\/strong><\/span><\/p>\n<\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>Endy \u8bf4\uff0c\u7ec6\u80de\u7684\u903b\u8f91\u95e8\u8fd8\u53ef\u4ee5\u505a\u66f4\u591a\u7684\u4e8b\u60c5\uff0c \u201c<strong>\u73b0\u5728\u5df2\u7ecf\u80fd\u591f\u7814\u7a76\u51fa\u8ba9\u5168\u5957\u5e03\u5c14\u903b\u8f91\u8fd0\u7b97\u7b26\u5728\u591a\u79cd\u4e0d\u540c\u7684\u7ec6\u80de\u4e2d\u8fd0\u884c\u4e86\uff0c\u6bcf\u79cd\u4e0d\u4e00\u6837\u7684\u7ec6\u80de\u5206\u522b\u91c7\u7528\u4e0d\u540c\u7684\u5206\u5b50\u673a\u5236\u6765\u5b9e\u73b0\u5404\u81ea\u7684\u529f\u80fd\u3002<\/strong>\u6700\u4ee4\u4eba\u5174\u594b\u7684\u662f\uff0c\u8fd9\u7c7b\u7814\u7a76\u5df2\u7ecf\u65e5\u6e10\u6210\u719f\u3002\u201d\u4ed6\u8bbe\u60f3\u4e86\u4e00\u4e2a\u53ef\u8ba1\u7b97\u81ea\u5df1\u5206\u88c2\u6b21\u6570\u7684\u7a0b\u5e8f\u7ec6\u80de\uff0c\u5982\u679c\u4e00\u4e9b\u7ec6\u80de\u5206\u88c2\u5f97\u8fc7\u5feb\uff08\u8fd9\u53ef\u80fd\u662f\u764c\u75c7\u7684\u65e9\u671f\u5f81\u5146\uff09\uff0c\u53ef\u4ee5\u89e6\u53d1\u7ec6\u80de\u7684\u7a0b\u5e8f\u6027\u6b7b\u4ea1\uff0c\u5728\u764c\u7ec6\u80de\u8fd8\u6ca1\u5927\u5230\u88ab\u5176\u4ed6\u6dcb\u5df4\u7ec6\u80de\u53d1\u73b0\u4e4b\u524d\uff0c\u5c31\u628a\u5b83\u627c\u6740\u5728\u6447\u7bee\u91cc\u3002<\/span><\/p>\n<\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>\u6765\u81ea\u5e72\u7ec6\u80de\u751f\u7269\u5b66\u548c\u518d\u751f\u533b\u5b66\u7814\u7a76\u6240\u7684\u65af\u5766\u798f\u7814\u7a76\u5458\u3001\u75c5\u7406\u5b66\u5bb6 Marius Wernig \u8bbe\u60f3\u521b\u9020\u201c\u667a\u80fd\u7ec6\u80de\u201d\uff1a\u53ef\u4ee5\u76d1\u6d4b\u8eab\u4f53\u5404\u79cd\u75be\u75c5\u8fc7\u7a0b\uff0c\u5e76\u5728\u51fa\u73b0\u95ee\u9898\u65f6\u91c7\u53d6\u884c\u52a8\u3002 \u60f3\u8981\u7814\u7a76\u51fa\u8fd9\u6837\u7684\u7ec6\u80de\u8fd8\u6709\u5f88\u957f\u7684\u8def\u8981\u8d70\uff0c\u4f46\u5e76\u975e\u4e0d\u53ef\u80fd\u3002\u6211\u4eec\u6b63\u5904\u5728\u4e00\u4e2a\u975e\u5e38\u6fc0\u52a8\u4eba\u5fc3\u7684\u65f6\u523b\uff0c\u56e0\u4e3a <strong>CRISPR \u548c\u5176\u4ed6\u57fa\u56e0\u5de5\u7a0b\u5de5\u5177\u4e3a\u8bbe\u8ba1\u201c\u667a\u80fd\u7ec6\u80de\u201d\u62d3\u5c55\u4e86\u65e0\u9650\u7684\u53ef\u80fd\u6027<\/strong>\u3002<\/span><\/p>\n<\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>Wernig \u4e3b\u8981\u7684\u7814\u7a76\u9886\u57df\u662f\u518d\u751f\u533b\u5b66\u3002\u4ed6\u7684\u5b9e\u9a8c\u5ba4\u7b2c\u4e00\u4e2a\u5c06\u4ea7\u751f\u76ae\u80a4\u7ec4\u7ec7\u7684\u7ec6\u80de\u8f6c\u53d8\u4e3a\u529f\u80fd\u6027\u795e\u7ecf\u5143\uff0c\u4e0d\u4ec5\u5982\u6b64\uff0c\u4ed6\u8fd8\u5229\u7528\u6210\u4eba\u4ea7\u751f\u7684\u5e72\u7ec6\u80de\u6765\u6cbb\u7597\u8425\u517b\u4e0d\u826f\u7684\u5927\u75b1\u6027\u8868\u76ae\u677e\u89e3\u75c7\uff0c\u8fd9\u662f\u4e00\u79cd\u5bfc\u81f4\u76ae\u80a4\u8d77\u6c34\u6ce1\u548c\u88c2\u7f1d\u7684\u9057\u4f20\u6027\u75be\u75c5\u3002\u4ed6\u7684\u76ee\u6807\u662f\uff1a\u4ece\u60a3\u8005\u8eab\u4e0a\u91c7\u96c6\u7ec6\u80de\uff0c\u5c06\u5176\u8f6c\u5316\u4e3a\u5e72\u7ec6\u80de\uff0c\u901a\u8fc7\u9057\u4f20\u7f16\u8f91\u5de5\u5177\u5bf9 DNA \u8fdb\u884c\u9057\u4f20\u4fee\u9970\uff0c\u7136\u540e\u5c06\u5176\u8f6c\u53d8\u6210\u6b63\u5e38\u7684\u76ae\u80a4\u7ec4\u7ec7\uff0c\u4f5c\u4e3a\u65b0\u7684\u76ae\u80a4\u79fb\u690d\u5230\u53d7\u635f\u7684\u76ae\u80a4\u7ec4\u7ec7\u4e0a\u3002\u4ed6\u5e0c\u671b\u8fd9\u79cd\u6cbb\u7597\u80fd\u5728\u4e24\u5230\u4e09\u5e74\u5185\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002<\/span><\/p>\n<\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>\u4e3a\u4e86\u4e86\u89e3\u7f16\u8f91\u540e\u7684\u7ec6\u80de\u662f\u5982\u4f55\u6539\u53d8\u7ec6\u80de\u7684\u884c\u4e3a\u7684\uff0cWernig \u548c\u4ed6\u7684\u540c\u4e8b\u4f7f\u7528 CRISPR \u5206\u522b\u6539\u53d8\u4e0d\u540c\u7684\u5355\u4e2a\u56e0\u5b50\uff0c\u7136\u540e\u5bf9\u591a\u4e2a\u7ec4\u5408\u56e0\u5b50\u8fdb\u884c\u4fee\u6539\u3002\u4ed6\u4eec<span>\u6ca1\u6709\u526a\u5207\u6216\u589e\u52a0\u7ec6\u80de\u57fa\u56e0\u7ec4\u7684DNA<\/span>\uff0c\u800c\u662f\u6253\u5f00\u6216\u5173\u95ed\u4eba\u7c7b\u7ec6\u80de\u4e2d\u7684\u8f6c\u5f55\u56e0\u5b50\uff0c\u4ee5\u89c2\u5bdf\u8fd9\u5e26\u6765\u7684\u5f71\u54cd\u3002\u4ed6\u5bf92000\u591a\u4e2a\u8f6c\u5f55\u56e0\u5b50\uff0c\u4ee5\u53ca\u4e00\u4e9b\u53eb\u505a\u67d3\u8272\u8d28\u4fee\u9970\u4f53\uff08chromatin modifiers\uff09\u7684DNA\u8c03\u8282\u9176\uff08DNA tweaking enzymes\uff09\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u76f8\u5f53\u4e8e\u628a\u7ec6\u80de\u673a\u5668\u91cc\u7684\u6bcf\u4e00\u4e2a\u87ba\u4e1d\u9489\u90fd\u5404\u81ea\u62e7\u5f00\u4e86\u4e00\u904d\uff0c\u770b\u770b\u7ec6\u80de\u7684\u53cd\u5e94\u3002<\/span><\/p>\n<\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em\"><span>Patrick Cahan\uff0c\u662f\u6765\u81ea\u9a6c\u91cc\u5170\u5dde\u5df4\u5c14\u7684\u6469\u5e02 \u7ea6\u7ff0\u65af\u970d\u666e\u91d1\u65af\u5927\u5b66 \u7ec6\u80de\u5de5\u7a0b\u7814\u7a76\u6240\u7684\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6\u3002Cahan \u8bf4\uff0c<strong>\u8fd9\u79cd\u7cfb\u7edf\u5de5\u7a0b\u65b9\u6cd5\u662f\u5bfb\u627e\u751f\u7269\u5b66\u7b54\u6848\u7684\u4e00\u79cd\u65b0\u65b9\u6cd5\uff0c\u5177\u6709\u65e0\u9650\u7684\u53ef\u80fd\u6027<\/strong>\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\uff0c\u53ef\u4ee5\u5b9a\u91cf\u89c2\u5bdf\u5230\u65e0\u6570\u7684\u57fa\u56e0\u7ec4\u5408\u7684\u5f00\u542f\u548c\u5173\u95ed\uff0c\u751a\u81f3\u662f\u90a3\u4e9b\u5728\u51e0\u5341\u5e74\u7684\u53d1\u80b2\u751f\u7269\u5b66\u7814\u7a76\u4e2d\u4ecd\u672a\u80fd\u5b9a\u91cf\u7684\u57fa\u56e0\u3002<\/span><\/p>\n<section class=\"mpa-template\">\n<section>\n<section>\n<section><strong><\/p>\n<p><span style=\"font-size: 16px\"><strong>\u7ec6\u80de\u5de5\u7a0b\u7684\u6570\u636e\u5904\u7406<\/strong><\/span><\/p>\n<p><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"ql-long-16599236\"><span><\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span>Cahan \u8bf4\uff0c\u8ba1\u7b97\u673a\u79d1\u5b66\u5728\u7ec6\u80de\u5de5\u7a0b\u4e2d\u626e\u6f14\u7740\u91cd\u8981\u7684\u89d2\u8272\u3002\u6709\u90e8\u5206\u539f\u56e0\u662f\u50cf Wernig \u7684\u5b9e\u9a8c\u90a3\u6837\uff0c\u8ba1\u7b97\u673a\u53ef\u4ee5\u4ea7\u751f\u5927\u91cf\u7684\u6570\u636e\uff0c\u8fd8\u53ef\u4ee5\u786e\u5b9a\u54ea\u4e9b\u57fa\u56e0\u5728\u54ea\u79cd\u7279\u5b9a\u7684\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u54ea\u4e9b\u57fa\u56e0\u4e0d\u8868\u8fbe\uff0c\u5176\u8868\u8fbe\u7684\u91cf\u5982\u4f55\u3002\u8fd9\u4e9b\u7ed3\u679c\u53ef\u80fd\u662f\u4e00\u4e2a\u6570\u636e\u96c6\uff0c\u5176\u4e2d\u5305\u542b\u4e86\u6570\u5343\u4e2a\u7ec6\u80de\u4e2d\u5178\u578b\u768420000-30000\u4e2a\u53d8\u91cf\u3002<strong>\u8981\u7406\u89e3\u6240\u6709\u8fd9\u4e9b\u6570\u636e\uff0c\u5c24\u5176\u662f\u5f53\u8bb8\u591a\u4e0d\u540c\u7684\u56e0\u7d20\u4ee5\u590d\u6742\u7684\u7ec4\u5408\u5de5\u4f5c\u65f6\uff0c\u9700\u8981\u8ba1\u7b97\u673a\u5efa\u6a21\u548c\u673a\u5668\u5b66\u4e60\u8fdb\u884c\u5904\u7406\u3002<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><img class=\"\" style=\"width: 100%;height: auto\" src=\"http:\/\/swarma.org\/wp-content\/uploads\/2019\/01\/swarma10-1547557235.jpeg\" alt=\"\u96c6\u667a\" title=\"\u96c6\u667a\" \/><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;text-align: center\"><span><strong><span style=\"font-size: 13px\">\u5236\u4f5c\uff1aDavid Parkins<\/span><\/strong><\/span><\/p>\n<\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span>Cahan \u7684\u76ee\u6807\u662f\u786e\u4fdd\u4ed6\u7684\u6240\u6709\u5b66\u751f\u5bf9\u57fa\u56e0\u7ec4\u89c4\u6a21\u7684\u8ba1\u7b97\u90fd\u80fd\u975e\u4fe1\u975e\u7591\uff1a\u786e\u4fe1\u8ba1\u7b97\u53ef\u4ee5\u63d0\u4f9b\u6709\u4ef7\u503c\u7684\u7b54\u6848\uff0c\u4f46\u662f\u4e5f\u8981\u8ba4\u8bc6\u5230\u6570\u636e\u4e0d\u80fd\u56de\u7b54\u54ea\u4e9b\u95ee\u9898\u3002\u4ed6\u8ba4\u4e3a\u5e94\u8be5\u4ece\u5b9e\u9a8c\u4e00\u5f00\u59cb\u5c31\u8bbe\u8ba1\u4e00\u9879\u9884\u5b9e\u9a8c\uff0c\u4ee5\u786e\u4fdd\u7814\u7a76\u4eba\u5458\u83b7\u5f97\u7684\u6570\u636e\u80fd\u591f\u8ba9\u4ed6\u4eec\u83b7\u5f97\u4ed6\u4eec\u6b63\u5728\u5bfb\u6c42\u7684\u7b54\u6848\u3002<\/span><\/p>\n<\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span>\u5bf9\u4e8e\u7f3a\u4e4f\u7ecf\u9a8c\u7684\u7814\u7a76\u4eba\u5458\u6765\u8bf4\uff0c\u4ed6\u4eec\u4f1a\u5c06\u6570\u636e\u7ec4\u7ec7\u8d77\u6765\u4ee5\u7b26\u5408\u4ed6\u4eec\u7684\u5047\u8bbe\uff0c\u81ea\u4ee5\u4e3a\u770b\u5230\u4e86\u67d0\u4e9b\u4e1c\u897f\u3002\u7136\u800c\u4ed6\u4eec\u4e0d\u4ec5\u5f88\u5bb9\u6613\u72af\u8fd9\u6837\u7684\u9519\u8bef\uff0c\u800c\u4e14\u4e5f\u5f88\u53ef\u80fd\u72af\u76f8\u53cd\u7684\u9519\u8bef\uff1a<span>\u5f53\u770b\u5230\u4e0e\u5047\u8bbe\u7684\u4e0d\u7b26\u65f6\uff0c\u6709\u4e9b\u4eba\u53ef\u80fd\u4f1a\u8ba4\u4e3a\u5b83\u662f\u8fd9\u4e2a\u5927\u89c4\u6a21\u6570\u636e\u96c6\u7684\u67d0\u79cd\u5047\u8c61<\/span>\uff0c\u5e76\u5ffd\u7565\u5b83\u3002\u800cCahan \u8bf4\uff1a\u8fd9\u4e9b\u6570\u636e\u53ef\u80fd\u5c31\u662f\u5b9d\u77f3\u3002<\/span><\/p>\n<\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span>Krishnendu Roy \u662f\u4e00\u540d\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5e08\uff0c\u6307\u5bfc\u4f4d\u4e8e\u4e9a\u7279\u5170\u5927 \u4f50\u6cbb\u4e9a\u7406\u5de5\u5b66\u9662\u7684\u56fd\u5bb6\u79d1\u5b66\u57fa\u91d1\u4f1a \u7ec6\u80de\u5236\u9020\u5de5\u7a0b\u7814\u7a76\u4e2d\u5fc3\u3002\u4ed6\u8bf4\uff0c\u867d\u7136\u4eba\u4eec\u5df2\u7ecf\u975e\u5e38\u64c5\u957f\u5236\u9020\u65e0\u751f\u547d\u7684\u7269\u4f53\uff0c\u751a\u81f3\u662f\u5236\u9020\u76f8\u5bf9\u7b80\u5355\u7684\u751f\u7269\u4ea7\u54c1\uff0c\u5982\u5355\u514b\u9686\u6297\u4f53\uff08monoclonal antibodies\uff09\u7684\u836f\u7269\uff0c\u4f46\u662f\u7ec6\u80de\u7684\u5de5\u4e1a\u751f\u4ea7\u4ecd\u662f\u4e00\u4e2a\u5168\u65b0\u7684\u9886\u57df\u3002Roy \u8bf4\uff1a\u201c\u8fd9\u53ef\u80fd\u662f\u4eba\u7c7b\u5386\u53f2\u4e0a\u7684\u7b2c\u4e00\u6b21\uff0c\u6211\u4eec\u6b63\u8bd5\u56fe\u8fdb\u884c\u5de5\u4e1a\u89c4\u6a21\u5316\u5730\u751f\u4ea7\u2018\u751f\u547d\u2019\u3002\u800c\u8fd9\u6574\u4e2a\u5236\u9020\u6a21\u5f0f\u662f\u4e0d\u80fd\u6cbf\u88ad\u4f20\u7edf\u7684\u751f\u4ea7\u6a21\u5f0f\u7684\u3002\u201d<\/span><\/p>\n<\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><strong><span>\u6211\u4eec\u9762\u4e34\u7684\u4e3b\u8981\u6311\u6218\u662f\uff1a\u6d3b\u7ec6\u80de\u5f80\u5f80\u4f1a\u968f\u7740\u73af\u5883\u7684\u53d8\u5316\u800c\u53d8\u5316\u3002<\/span><\/strong><span>\u4e0d\u540c\u6279\u6b21\u7684\u8bd5\u5242\u3001\u5bb9\u5668\u6750\u6599\uff0c\u65e0\u8bba\u5b83\u4eec\u662f\u4e8c\u7ef4\u8fd8\u662f\u4e09\u7ef4\u7ed3\u6784\uff0c\u751a\u81f3\u7535\u573a\u7684\u5b58\u5728\uff0c\u90fd\u4f1a\u4fee\u6539\u89e6\u53d1\u7684\u57fa\u56e0\uff0c\u4f7f\u86cb\u767d\u8d28\u53d1\u751f\u7a81\u53d8\u751a\u81f3\u6539\u53d8\u672c\u6765\u5e94\u8be5\u4ea7\u751f\u7684\u4ee3\u8c22\u7269\u3002<\/span><\/p>\n<\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span>Roy \u8bf4\uff1a\u201c\u8fd9\u662f\u4e00\u4e2a\u975e\u5e38\u654f\u611f\u7684\u4ea7\u54c1\uff0c\u5b83\u4f1a\u968f\u7740\u8f7b\u5fae\u7684\u64cd\u4f5c\u800c\u53d8\u5316\u3002\u8fd9\u4e9b\u53d8\u5316\u662f\u5426\u91cd\u8981\uff0c\u6211\u4eec\u4ecd\u7136\u9700\u8981\u5f04\u6e05\u695a\uff0c\u201d \u5bf9\u4e8e\u7ec6\u80de\u5de5\u7a0b\u7684\u4ea7\u54c1\uff0c\u5de5\u7a0b\u5e08\u9700\u8981\u4e86\u89e3\u751f\u7269\u7684\u4ee3\u8c22\u8fc7\u7a0b\uff0c\u751f\u7269\u5b66\u5bb6\u9700\u8981\u4e86\u89e3\u5de5\u4e1a\u751f\u4ea7\u7684\u7cfb\u7edf\u3002<span>\u5982\u679c\u5355\u7eaf\u628a\u4e00\u7fa4\u5de5\u7a0b\u5e08\u805a\u96c6\u5728\u4e00\u8d77\uff0c\u6ca1\u6709\u4e00\u5f20\u8bbe\u8ba1\u56fe\u7eb8\u7684\u8bdd\uff0c\u6c38\u8fdc\u4e5f\u5f97\u5230\u4e0d\u4e86\u60f3\u8981\u7684\u7ed3\u679c\u3002<\/span><\/span><\/p>\n<section class=\"mpa-template\">\n<section>\n<section>\n<section><strong><\/p>\n<p><span style=\"font-size: 16px\"><strong>\u7ec6\u80de\u5de5\u7a0b\u5e08<\/strong><\/span><\/p>\n<p><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"ql-long-16599236\"><span><\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><strong><span>\u7ec6\u80de\u5de5\u7a0b\u662f\u4e00\u4e2a\u591a\u5b66\u79d1\u4ea4\u53c9\u7684\u9886\u57df\uff0c\u5bf9\u7814\u7a76\u4eba\u5458\u6765\u8bf4\uff0c\u4e86\u89e3\u6d89\u53ca\u4ed6\u4eec\u5de5\u4f5c\u7684\u6240\u6709\u4e13\u4e1a\u662f\u5f88\u91cd\u8981\u7684\u3002<\/span><\/strong><span>Roy \u8bf4\uff1a\u201c\u73b0\u5728\uff0c\u6709\u4e86\u7ec6\u80de\u751f\u7269\u5b66\u3001\u533b\u7597\u4fdd\u5065\u548c\u6570\u636e\u79d1\u5b66\u8fd9\u4e9b\u9886\u57df\u4ea4\u53c9\u8d2f\u901a\uff0c\u6211\u4eec\u5bf9\u7ec6\u80de\u7684\u5177\u4f53\u7279\u5f81\u66f4\u52a0\u5730\u4e86\u5982\u6307\u638c\u3002\u201d<\/span><\/p>\n<\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span>Endy \u66fe\u5e2e\u52a9\u65af\u5766\u798f\u5927\u5b66\u548c\u5251\u6865\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u8bbe\u8ba1\u751f\u7269\u5de5\u7a0b\u672c\u79d1\u8bfe\u7a0b\u2014\u2014\u300a\u79d1\u5b66\u4e0e\u5de5\u7a0b\u7684\u7ed3\u5408\u70b9\u300b\u3002\u4ed6\u8ba4\u4e3a\uff0c\u7ed3\u5408\u5404\u4e2a\u9886\u57df\u7684\u4e13\u4e1a\u77e5\u8bc6\u548c\u89e3\u51b3\u95ee\u9898\u7684\u65b9\u6cd5\uff0c\u4f8b\u5982\uff1a\u5206\u5b50\u751f\u7269\u5b66\u3001\u751f\u7269\u4fe1\u606f\u5b66\u3001\u5316\u5b66\u5de5\u7a0b\u3001\u5de5\u4e1a\u5de5\u7a0b\u7b49\uff0c\u624d\u80fd\u4f7f\u7ec6\u80de\u5de5\u7a0b\u5b9e\u73b0\u3002\u5f53\u79d1\u5b66\u5bb6\u548c\u5de5\u7a0b\u5e08\u770b\u5f85\u79d1\u5b66\u95ee\u9898\u65f6\uff0c\u4e24\u8005\u7684\u89d2\u5ea6\u662f\u4e0d\u4e00\u6837\u7684\uff0c\u5bf9\u4e8e\u5de5\u7a0b\u5e08\u6765\u8bf4\uff0c\u91cd\u8981\u7684\u662f\u662f\u5426\u80fd\u8fbe\u5230\u5de5\u4f5c\u7ed3\u679c\uff1b\u7136\u800c\u5bf9\u751f\u7269\u5b66\u5bb6\u6765\u8bf4\uff0c\u66f4\u91cd\u8981\u7684\u6700\u7ec8\u6210\u679c\u662f\u77e5\u8bc6\uff0c\u4ee5\u53ca\u5982\u4f55\u63cf\u8ff0\u8fd9\u4e2a\u751f\u7269\u5b66\u77e5\u8bc6\u7684\u539f\u7406\u3002<\/span><\/p>\n<\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><strong><span>Endy \u5bf9\u7ec6\u80de\u5de5\u7a0b\u5e08\u63d0\u51fa\u4e86\u4ee5\u4e0b\u51e0\u70b9\u5efa\u8bae\u3002<\/span><\/strong><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span><\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span>\u7b2c\u4e00\uff0c\u5728\u591a\u4e2a\u9886\u57df\u90fd\u6709\u4e00\u5b9a\u7684\u77e5\u8bc6\u3002Endy \u8bf4\uff1a\u201c<span>\u4e00\u540d\u7ed3\u6784\u5de5\u7a0b\u5e08\u9700\u8981\u4e86\u89e3\u6df7\u51dd\u571f\u94a2\u7b4b\uff0c\u6bd4\u5982\u6768\u6c0f\u6a21\u91cf\u3001\u5e94\u529b\u3001\u5e94\u53d8\u8fd9\u4e9b\u77e5\u8bc6\u7b49\u3002\u800c\u4e00\u4e2a\u751f\u7269\u5de5\u7a0b\u5e08\uff0c\u5219\u5fc5\u987b\u4e86\u89e3\u7ec6\u80de\uff0c\u5206\u5b50\uff0c\u7ec4\u7ec7\u3002\u201d<\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span><\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span>\u7b2c\u4e8c\uff0c\u4e86\u89e3\u7cfb\u7edf\u8bbe\u8ba1\u3002\u65e0\u8bba\u662f\u627e\u5230\u5efa\u7b51\u7269\u9700\u8981\u652f\u67f1\u652f\u6491\u7684\u4f4d\u7f6e\uff0c\u8fd8\u662f\u7ec6\u80de\u9700\u8981\u7279\u5b9a\u86cb\u767d\u8d28\u53d1\u6325\u4f5c\u7528\u7684\u4f4d\u7f6e\u3002<span>\u4f46\u662f\u5728\u7406\u79d1\u4e13\u4e1a\u4e2d\u4e00\u822c\u662f\u4e0d\u80fd\u627e\u5230\u4e00\u95e8\u786e\u5207\u8bb2\u7cfb\u7edf\u8bbe\u8ba1\u7c7b\u8bfe\u7a0b\u7684\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span><\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span>\u7b2c\u4e09\uff0c\u77e5\u9053\u4ec0\u4e48\u662f\u53ef\u80fd\u7684\u3002\u6b63\u5982\u4e00\u4e2a\u5de5\u7a0b\u5e08\u9700\u8981\u8ba4\u8bc6\u5230\uff0c\u6ca1\u6709\u6c34\u6cf5\uff0c\u6c34\u5c31\u4e0d\u4f1a\u9006\u5730\u5fc3\u5f15\u529b\u800c\u8d70\uff0c\u800c\u7ec6\u80de\u5de5\u7a0b\u5e08\u9700\u8981\u4e86\u89e3\u7ec6\u80de\u7684\u5404\u4e2a\u90e8\u5206\u662f\u5982\u4f55\u76f8\u4e92\u4f5c\u7528\u7684\u3002\u201c\u6211\u4eec\u9700\u8981\u6df1\u5165\u7814\u7a76\u751f\u547d\u7684\u7269\u7406\u5b66\u77e5\u8bc6\u3002\u201d<\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span><\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span>\u7b2c\u56db\uff0c\u627e\u5230\u4e00\u4e2a\u95ee\u9898\u3002Endy \u8bf4\uff1a\u201c\u4e00\u4e2a\u4ece\u4e8b\u751f\u7269\u5b66\u5de5\u4f5c\u5e76\u9009\u62e9\u4e86\u4ece\u4e8b\u9886\u57df\u7684\u79d1\u5b66\u5bb6\u53ef\u80fd\u9996\u5148\u4f1a\u95ee\uff1a\u2018\u4ec0\u4e48\u662f\u4e00\u4e2a\u597d\u7684\u79d1\u5b66\u95ee\u9898\uff1f\u2019\u7136\u800c\uff0c\u4e00\u4e2a\u5de5\u7a0b\u5e08\u53ef\u80fd\u4f1a\u8bf4\uff1a\u2018\u58a8\u897f\u54e5\u9999\u8349\u519c\u573a\u53d1\u751f\u4e86\u4ec0\u4e48\u4e8b\uff0c\u6211\u80fd\u505a\u4e9b\u4ec0\u4e48\u6765\u6539\u5584\u5b83\u5417\uff1f\u2019\u201d<\/span><\/p>\n<\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span>\u6240\u6709\u7684\u7ec6\u80de\u5de5\u7a0b\u5e08\u90fd\u8ba4\u4e3a\uff0c\u4ed6\u4eec\u5fc5\u987b\u4ece\u4ed6\u4eec\u7684\u4e13\u4e1a\u9886\u57df\u4e4b\u5916\u5b66\u5f88\u591a\u4e1c\u897f\u3002\u4f8b\u5982\uff0cYvonne \u5fc5\u987b\u5b66\u4e60\u5982\u4f55\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5979\u6ce8\u610f\u5230\u6709\u4e00\u4e2a\u95ee\u9898\uff0c\u5c31\u662f\u8981\u786e\u5b9a\u4e00\u79cd\u836f\u7269\u7684\u4f53\u79ef\uff0c\u800c\u8fd9\u79cd\u836f\u7269\u5fc5\u987b\u80fd\u591f\u51c6\u786e\u5730\u6ce8\u5165\u75c5\u4eba\u4f53\u5185\u3002\u5979\u4e0d\u4ec5\u8981\u8003\u8651\u5979\u6240\u505a\u7684\u52aa\u529b\u662f\u5426\u6210\u529f\uff0c\u8fd8\u8981\u8003\u8651\u5979\u80fd\u5426\u4ee5\u4e00\u79cd\u53ef\u7533\u8bf7\u4e13\u5229\u7684\u65b9\u5f0f\u8fdb\u884c\u514d\u75ab\u6cbb\u7597\u3002\u514d\u75ab\u6cbb\u7597\u662f\u975e\u5e38\u6602\u8d35\u7684\uff0c\u56e0\u6b64\u7ef4\u62a4\u77e5\u8bc6\u4ea7\u6743\u6709\u52a9\u4e8e\u652f\u4ed8\u4e34\u5e8a\u8bd5\u9a8c\u8d39\u7528\u3002<\/span><\/p>\n<\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><strong><span>\u5728 Endy \u770b\u6765\uff0c\u8fd9\u4e2a\u9886\u57df\u4e0d\u4ec5\u4f53\u73b0\u4e86\u4e00\u7cfb\u5217\u65b0\u7684\u79d1\u5b66\u548c\u5de5\u7a0b\u95ee\u9898\uff0c\u800c\u4e14\u8fd8\u66b4\u9732\u51fa\u4e86\u4f26\u7406\u548c\u653f\u7b56\u7684\u95ee\u9898\u3002<\/span><\/strong><span>\u4ed6\u8bf4\uff1a\u201c\u6211\u4eec\u6709\u8db3\u591f\u7684\u80fd\u529b\u8ba9100\u4ebf\u4eba\u5728\u4e0d\u7834\u574f\u5730\u7403\u7684\u60c5\u51b5\u4e0b\u7e41\u8363\u8d77\u6765\u3002\u800c\u8981\u8fbe\u5230\u8fd9\u4e2a\u76ee\u6807\u7684\u524d\u63d0\u662f\uff1a\u6211\u4eec\u9700\u8981\u786e\u4fdd\u5bf9\u2018\u751f\u547d\u2019\u6709\u8db3\u591f\u7684\u638c\u63a7\u80fd\u529b\u3002\u9884\u8ba1\u52302030\u5e74\u5de6\u53f3\u6216\u8005\u4e4b\u524d\uff0c\u6211\u4eec\u5c06\u80fd\u591f\u505a\u5230\u3002\u201d<\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span><\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px\"><span>\u4f46\u662f\uff0c\u65b0\u9886\u57df\u7684\u53d1\u5c55\u4e5f\u4e0d\u7981\u4ee4\u4eba\u53d1\u95ee\uff1a\u6211\u4eec\u7a76\u7adf\u671f\u671b\u751f\u7269\u80fd\u591f\u5e26\u7ed9\u6211\u4eec\u4ec0\u4e48\u5462\uff1f\u6211\u4eec\u4e0e\u751f\u7269\u7684\u5173\u7cfb\u53c8\u5e94\u8be5\u5982\u4f55\u5462\uff1f<\/span><\/p>\n<\/p>\n<section class=\"mpa-template\">\n<section>\n<section>\n<section><strong><\/p>\n<p><span style=\"font-size: 16px\">\u53c2\u8003\u6587\u7ae0<\/span><\/p>\n<p><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><span><\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;text-align: left\"><span>1. Zah, E. <em style=\"color: #7b7f83\">et al<\/em>. <em style=\"color: #7b7f83\">Cancer Immunol. Res. <\/em><strong style=\"color: #7b7f83\">4<\/strong>, 498\u2013508 (2016).<\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;text-align: left\"><span>2. Vierbuchen, T. <em style=\"color: #7b7f83\">et al<\/em>. <em style=\"color: #7b7f83\">Nature <\/em><strong style=\"color: #7b7f83\">463<\/strong>, 1035\u20131041 (2010).<\/span><\/p>\n<p style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;text-align: left\"><span>3. Liu, Y. <em style=\"color: #7b7f83\">et al<\/em>. <em style=\"color: #7b7f83\">Cell Stem Cell <\/em><strong style=\"color: #7b7f83\">23<\/strong>, 758\u2013771.E8 (2018).<\/span><\/p>\n<p><span><\/span><\/p>\n<p><span><\/span><\/p>\n<blockquote>\n<p><span>\u4f5c\u8005\uff1aNeil Savage<\/span><\/p>\n<p><span>\u7ffb\u8bd1\uff1a\u70ef\u667a<\/span><\/p>\n<p><span>\u7f16\u8f91\uff1a\u6768\u6e05\u6021<\/span><\/p>\n<p><span>\u539f\u6587\u5730\u5740\uff1a<\/span><\/p>\n<p><span>https:\/\/www.nature.com\/articles\/d41586-018-07595-4<\/span><\/p>\n<\/blockquote>\n<p style=\"margin-right: 8px;margin-left: 8px\">\n<section>\n<section>\n<section><strong><\/p>\n<p><span><strong>\u63a8\u8350\u9605\u8bfb<\/strong><\/span><\/p>\n<p><\/strong><\/section>\n<\/section>\n<\/section>\n<p><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247492586&amp;idx=1&amp;sn=db15b8d87dbaf5abc15993b6ad78bcea&amp;chksm=e897b967dfe030718b17e0088378a7e6007886cca4510855db86829d26bc6d5001170c8e93df&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"font-size: 14px;text-decoration: underline\"><strong><span style=\"font-size: 14px\">\u8fdb\u5316\u65b0\u89c6\u89d2\uff1a\u57fa\u56e0\u7684\u91cd\u590d\u535a\u5f08\u5982\u4f55\u5f71\u54cd\u751f\u7269\u8fdb\u5316<\/span><\/strong><\/a><\/p>\n<p><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247494777&amp;idx=1&amp;sn=f8371c9f275fb287736993ab2bb084c7&amp;chksm=e897b6f4dfe03fe2934ab2e862bef13bdaac7e2893d872a8979a7011e8c0b0f0198d48cd6e5e&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"font-size: 14px;text-decoration: underline\"><strong><span style=\"font-size: 14px\">Cell\u957f\u6587\u7efc\u8ff0\uff1a\u673a\u5668\u5b66\u4e60\u5982\u4f55\u52a9\u529b\u7f51\u7edc\u751f\u7269\u5b66<\/span><\/strong><\/a><\/p>\n<p><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247493835&amp;idx=1&amp;sn=79d5757eb3a6bdfb0988b4c3cd7a6a51&amp;chksm=e897b246dfe03b50215401742794c67eb09fc8affb2ae4abd6fa981400fab59f821c76889f9b&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"font-size: 14px;text-decoration: underline\"><strong><span style=\"font-size: 14px\">\u5bbf\u4e3b\u4e0e\u5fae\u751f\u7269\u6784\u6210\u7684\u201c\u8d85\u7ea7\u751f\u7269\u4f53\u201d\u5982\u4f55\u6f14\u5316\uff1f<\/span><\/strong><\/a><\/p>\n<p><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247490504&amp;idx=1&amp;sn=6961f71f9ec2a15053e66309226693d4&amp;chksm=e8944145dfe3c85368a51111ed0808231ac9a810739c43de16fb8e7c6fd72e71198cc89ca7eb&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"font-size: 14px;text-decoration: underline\"><strong><span style=\"font-size: 14px\">\u7956\u6bcd\u5047\u8bf4\u3001\u8fdb\u5316\u56fe\u6a21\u578b\u4ee5\u53ca\u751f\u7269\u8fdb\u5316\u7684\u771f\u76f8<\/span><\/strong><\/a><\/p>\n<p><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247487778&amp;idx=1&amp;sn=c2e77ec93213c4c63f57a777ff10e368&amp;chksm=e8944bafdfe3c2b9d66544dafe7403159473e8c94fd3bc513f5300c353bcec49c0c0b69797af&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;letter-spacing: 2px;font-size: 14px\"><strong><span style=\"font-size: 14px\">\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/span><\/strong><\/a><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;text-align: center\"><img class=\"\" src=\"http:\/\/swarma.org\/wp-content\/uploads\/2019\/01\/swarma4-1547557235.jpg\" alt=\"\u96c6\u667a\" title=\"\u96c6\u667a\" \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;text-align: center\"><span>\u96c6\u667aAI\u5b66\u56ed\uff1a<\/span><\/p>\n<p style=\"text-align: center\"><span>https:\/\/campus.swarma.org<\/span><\/p>\n<section class=\"mpa-template\">\n<section class=\"\">\n<section class=\"\">\n<hr \/>\n<div class=\"post-image\"><img class=\"__bg_gif\" width=\"100%\" style=\"letter-spacing: 0.5px;width: 64px !important\" src=\"http:\/\/swarma.org\/wp-content\/uploads\/2019\/01\/swarma8-1547557236.gif\" alt=\"\u96c6\u667a\" title=\"\u96c6\u667a\" \/><\/div>\n<section>\n<section style=\"margin-right: 0.5em;margin-left: 0.5em;line-height: 25.6px;text-align: center\">\n<section style=\"margin-right: 0.5em;margin-left: 0.5em;line-height: 25.6px\">\n<section>\n<section style=\"margin-right: 0.5em;margin-left: 0.5em;font-size: 15px\">\n<section>\n<p><strong><span>\u96c6\u667a\u4ff1\u4e50\u90e8QQ\u7fa4\uff5c877391004<\/span><\/strong><\/p>\n<p><strong><span>\u5546\u52a1\u5408\u4f5c\u53ca\u6295\u7a3f\u8f6c\u8f7d\uff5cswarma@swarma.org<\/span><\/strong><\/p>\n<section style=\"margin-right: 0.5em;margin-left: 0.5em\">\n<h1 style=\"margin-top: 10px;margin-bottom: 10px;line-height: 1.75em\"><strong><strong><span><span>\u25c6<\/span><span>\u25c6<\/span><span>\u25c6<\/span><\/span><\/strong><\/strong><\/h1>\n<\/section>\n<p><span><strong><span style=\"font-size: 14px\">\u641c\u7d22\u516c\u4f17\u53f7\uff1a\u96c6\u667a\u4ff1\u4e50\u90e8<\/span><\/strong><\/span><\/p>\n<\/p>\n<p><span><strong><span style=\"font-size: 14px\">\u52a0\u5165\u201c\u6ca1\u6709\u56f4\u5899\u7684\u7814\u7a76\u6240\u201d<\/span><\/strong><\/span><\/p>\n<section>\n<div class=\"post-image\"><img class=\"\" style=\"width: 156px !important\" src=\"http:\/\/swarma.org\/wp-content\/uploads\/2019\/01\/swarma10-1547557236.jpg\" alt=\"\u96c6\u667a\" title=\"\u96c6\u667a\" \/><\/div>\n<\/section>\n<p><span style=\"font-size: 14px\">\u8ba9\u82f9\u679c\u7838\u5f97\u66f4\u731b\u70c8\u4e9b\u5427\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<blockquote class=\"keep-source\">\n<p>\u539f\u6587\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff08\u96c6\u667a\u4ff1\u4e50\u90e8\uff09\uff1a<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?timestamp=1547557230&amp;src=3&amp;ver=1&amp;signature=uUWy-sA1v0LDa20t6pIF2Rlb03UDQDKXS6vaDRhCycjMme664Jz3LpvZzZjYmNavqjIcs7uK-d0LiRVawPt-7Sa36v54lwbf8qRAZyGZDQLfqgQS2FTE01GaYeq4dSHcj9voCNw8TopWQ3pTXkqgVx7a1hPoid*9UyMFAzmOFKg=\">\u96c6\u667a<\/a><\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5236\u4f5c\uff1aDavid Parkins \u5bfc\u8bed \u968f\u7740\u751f\u7269\u6280\u672f\u7684\u9010\u65e5\u53d1\u5c55\uff0c\u8de8\u5b66\u79d1\u5728\u64cd\u63a7\u7ec6\u80de\u529f\u80fd\u65b9\u9762\u8d77\u7740\u65e0\u4e0e\u4f26\u6bd4\u7684\u4f5c\u7528\u3002\u7ec6\u80de\u5de5\u7a0b\u5e08\u5c06\u9762\u4e34\u7740\u524d\u6240\u672a\u6709\u7684\u6311\u6218\uff0c\u8fd9\u6311\u6218\u4e5f\u8bb8\u662f\u5212\u65f6\u7a7a\uff0c\u56e0\u4e3a\u8fd9\u538b\u529b\u4e0d\u4ec5\u662f\u6280\u672f\u4e0a\u7684\u96be\u9898\uff0c\u66f4\u591a\u7684\u662f\u4f26\u7406\u653f\u7b56\u4e0a\u7684\u77db\u76fe\u3002 \u7f16\u8bd1\uff1a\u96c6\u667a\u4ff1\u4e50\u90e8\u7ffb\u8bd1\u7ec4 \u6765\u6e90\uff1aNature \u539f\u9898\uff1a Computer logic&#8230;<\/p>\n","protected":false},"author":1,"featured_media":14402,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[17],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/14399"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=14399"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/14399\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/14402"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=14399"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=14399"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=14399"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=14399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}