{"id":19186,"date":"2020-04-22T17:41:51","date_gmt":"2020-04-22T09:41:51","guid":{"rendered":"https:\/\/swarma.org\/?p=19186"},"modified":"2020-04-22T17:41:51","modified_gmt":"2020-04-22T09:41:51","slug":"barabasi%e7%bb%84%e6%9c%80%e6%96%b0%ef%bc%9a%e7%bd%91%e7%bb%9c%e7%a7%91%e5%ad%a6%e5%a4%a7%e5%b9%85%e7%bc%a9%e5%b0%8f%e6%96%b0%e5%86%a0%e7%89%b9%e6%95%88%e8%8d%af%e6%90%9c%e7%b4%a2%e8%8c%83%e5%9b%b4","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=19186","title":{"rendered":"Barab\u00e1si\u7ec4\u6700\u65b0\uff1a\u7f51\u7edc\u79d1\u5b66\u5927\u5e45\u7f29\u5c0f\u65b0\u51a0\u7279\u6548\u836f\u641c\u7d22\u8303\u56f4\u81f381\u79cd"},"content":{"rendered":"
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\u75ab\u60c5\u671f\u95f4\uff0c\u8457\u540d\u7f51\u7edc\u79d1\u5b66\u5bb6 <\/span>Albert-L\u00e1szl\u00f3 Barab\u00e1si \u5e26\u9886\u79d1\u7814\u56e2\u961f\uff0c\u8fd0\u7528\u7f51\u7edc\u533b\u5b66\u7684\u65b9\u6cd5\u9884\u6d4b\u51fa\u80fd\u591f\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u7684\u5019\u9009\u836f\u7269\u3002\u8be5\u65b9\u6cd5\u6784\u5efa\u4e86\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\uff0c\u4ece\u7f51\u7edc\u7ed3\u6784\u7684\u5c42\u9762\u7814\u7a76\u65b0\u51a0\u80ba\u708e\u7684\u7279\u6027\uff0c\u6839\u636e\u7279\u6027\u9884\u6d4b\u5019\u9009\u836f\u7269\u3002\u79d1\u7814\u56e2\u961f\u76ee\u524d\u5df2\u8d2d\u4e70\u5019\u9009\u836f\u7269\u5728\u4eba\u4f53\u7ec4\u7ec7\u7ec6\u80de\u4e2d\u8fdb\u884c\u6d4b\u8bd5\uff0c\u5bf9\u6548\u679c\u597d\u7684\u5316\u5408\u7269\u5c06\u8fdb\u884c\u4e34\u5e8a\u6d4b\u8bd5\u3002<\/span>\u8fd1\u65e5\u5728 arXiv.org\u4e0a\u7ebf\u7684\u4e00\u7bc7\u9884\u5370\u672c\u8bba\u6587\u4e2d\uff0c\u63ed\u793a\u4e86\u8be5\u7814\u7a76\u6210\u679c\u3002<\/span><\/p>\n

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Network Medicine Framework for Identifying Drug Repurposing Opportunities for COVID-19<\/span><\/p>\n

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https:\/\/arxiv.org\/abs\/2004.07229<\/span><\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n

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\u5173\u4e8e AL Barab\u00e1si \u7684\u96c6\u667a\u767e\u79d1\uff1a<\/span><\/p>\n

https:\/\/wiki.swarma.org\/index.php?title=\u827e\u4f2f\u7279-\u62c9\u65af\u6d1b\u00b7\u5df4\u62c9\u5df4\u897f_Albert-L\u00e1szl\u00f3_Barab\u00e1si <\/span><\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n


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\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u5e38\u7528\u4e8e\u7f51\u7edc\u533b\u5b66\u7814\u7a76\u3002\u8be5\u7f51\u7edc\u4e2d\uff0c\u8282\u70b9\u4e3a\u86cb\u767d\u8d28\uff0c\u8fb9\u4e3a\u86cb\u767d\u8d28\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u5173\u7cfb\uff0c\u5982\u7269\u7406\u7ed3\u5408\u3002\u4eba\u4f53\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\uff08Human Interactome\uff09\u63ed\u793a\u4e86\u4eba\u4f53\u5185\u6240\u6709\u86cb\u767d\u8d28\u95f4\u7684\u5bc6\u5207\u8054\u7cfb\uff0c\u662f\u4e86\u89e3\u4eba\u4f53\u5185\u751f\u7269\u8fc7\u7a0b\u7684\u4e00\u5f20\u201c\u5730\u56fe\u201d\uff0c\u4e5f\u662f\u8be5\u8bba\u6587\u7684\u57fa\u7840\u3002<\/strong>\u4eba\u4f53\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u4f1a\u53d7\u5230\u4e24\u4e2a\u5916\u90e8\u56e0\u7d20\u7684\u5f71\u54cd\uff1a1. \u65b0\u51a0\u75c5\u6bd2\u5bf9\u4e8e\u4eba\u4f53\u86cb\u767d\u8d28\u7684\u5f71\u54cd\uff0c2. \u836f\u7269\u5bf9\u4e8e\u4eba\u4f53\u86cb\u767d\u8d28\u7684\u5f71\u54cd\u3002\u524d\u8005\u5f15\u8d77\u75be\u75c5\uff0c\u540e\u8005\u6cbb\u7597\u75be\u75c5\u3002<\/span><\/p>\n

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\u5728\u6574\u4e2a\u4eba\u4f53\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u4e2d\uff0c\u53d7\u65b0\u51a0\u75c5\u6bd2\u5f71\u54cd\u7684\u86cb\u767d\u8d28\u5f62\u6210\u4e00\u4e2a\u5b50\u56fe\uff0c\u79f0\u4f5c\u75be\u75c5\u6a21\u5757\uff08Viral Disease Module\uff09\u3002\u53d7\u836f\u7269\u4f5c\u7528\u7684\u86cb\u767d\u8d28\u5f62\u6210\u4e00\u4e2a\u5b50\u56fe\uff0c\u79f0\u4f5c\u6cbb\u7597\u6a21\u5757\uff08Drug Disease Module<\/span>\uff09\uff0c\u89c1\u4e0b\u56fe\u3002\u7814\u7a76\u4e24\u4e2a\u6a21\u5757\u4e4b\u95f4\u7684\u5173\u7cfb\u662f\u8be5\u8bba\u6587\u7684\u6838\u5fc3\uff1a\u5982\u679c\u67d0\u836f\u7269\u7684\u6cbb\u7597\u6a21\u5757\u53ef\u4ee5\u4f5c\u7528\u5230\u75be\u75c5\u6a21\u5757\u4e0a\u6216\u8005\u75be\u75c5\u6a21\u5757\u5468\u56f4\uff0c\u90a3\u4e48\u8be5\u836f\u7269\u5f88\u53ef\u80fd\u6709\u6cbb\u7597\u6548\u679c\u3002<\/strong><\/span><\/p>\n

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\u4f5c\u8005\u6839\u636e\u5df2\u6709\u6587\u732e\u7ed3\u679c\uff0c\u9009\u5b9a\u6bcf\u79cd\u75be\u75c5\u5bf9\u5e94\u4e00\u5b9a\u6570\u91cf\u7684\u81f4\u75c5\u86cb\u767d\uff0c\u4e5f\u5bf9\u5e94\u4e00\u4e2a\u75be\u75c5\u6a21\u5757\u3002\u7136\u540e\uff0c\u5c06\u65b0\u51a0\u80ba\u708e\u75be\u75c5\u6a21\u5757\u5206\u522b\u4e0e 299 \u4e2a\u75be\u75c5\u6a21\u5757\u8fdb\u884c\u6bd4\u5bf9<\/strong>\u3002\u7ed3\u679c\u53d1\u73b0\uff0c\u65b0\u51a0\u80ba\u708e\u75be\u75c5\u6a21\u5757\u4e0e\u5176\u4ed6\u4e00\u4e9b\u5982\u80ba\u90e8\u75be\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u764c\u75c7<\/strong>\u7b49\u75be\u75c5\u6a21\u5757\u5728\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u4e0a\u7684\u8ddd\u79bb\u5f88\u8fd1\uff0c\u5177\u6709\u76f8\u5173\u6027\uff0c\u89c1\u4e0b\u56fe\u3002\u6b64\u5916\uff0c\u65b0\u51a0\u80ba\u708e\u4e0e\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5<\/strong>\u5728\u7f51\u7edc\u4e0a\u5177\u6709\u76f8\u5173\u6027\uff0c\u8fd9\u89e3\u91ca\u4e86\u4e00\u4e9b\u60a3\u8005\u5728\u611f\u67d3\u521d\u671f\u4e27\u5931\u55c5\u89c9\u3001\u5473\u89c9\u529f\u80fd\u7684\u73b0\u8c61\u3002\u8fd9\u4e9b\u7ed3\u679c\u5728\u76f8\u5173\u6587\u732e\u4e2d\u5f97\u5230\u4f50\u8bc1\uff0c\u5e76\u4e14\u9884\u6d4b\u4e86\u5176\u4ed6\u53ef\u80fd\u53d1\u751f\u7684\u5e76\u53d1\u75c7\u3002<\/span><\/span><\/p>\n

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 <\/span><\/p>\n

<\/section>\n

\u56fe3\uff1a\u65b0\u51a0\u80ba\u708e\u4e0e 299 \u79cd\u75be\u75c5\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002 \u5706\u5708\u8868\u793a\u75be\u75c5\uff0c\u8d8a\u63a5\u8fd1\u4e2d\u5fc3\u7684\u5706\u5708\u4e0e\u65b0\u51a0\u80ba\u708e\u8d8a\u76f8\u5173\u3002\u5706\u5708\u5927\u5c0f\u53cd\u6620\u81f4\u75c5\u86cb\u767d\u6570\u91cf\uff0c\u989c\u8272\u53cd\u6620\u75be\u75c5\u6240\u5c5e\u7c7b\u578b\u3002<\/span><\/strong><\/span>
<\/p>\n

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\u8bba\u6587\u4e2d\u662f\u5982\u4f55\u6d4b\u91cf\u65b0\u51a0\u80ba\u708e\u75be\u75c5\u4e0e\u5176\u4ed6\u75be\u75c5\u7684\u76f8\u5173\u6027\u5462\uff1f\u5047\u8bbe\u8981\u8ba1\u7b97 A \u75be\u75c5\u548c B \u75be\u75c5\u7684\u76f8\u5173\u6027\uff08\u4ee5S\u503c\u8861\u91cf\uff09\uff0c\u90a3\u4e48\u6709\u4ee5\u4e0b\u516c\u5f0f\uff1a<\/span><\/section>\n

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      <\/span><\/p>\n

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<\/span><\/section>\n
\u5176\u4e2d\uff0c<<\/span>d<\/span>AB<\/span>>\u8868\u793a A \u6a21\u5757\u548cB\u6a21\u5757<\/strong>\u4e4b\u95f4\u4e24\u4e24\u914d\u5bf9\u8282\u70b9\u7684\u5e73\u5747\u6700\u77ed\u8def\u5f84\u957f\u5ea6\u3002<<\/span>d<\/span>AA<\/span>>\u3001<<\/span>d<\/span>BB<\/span>>\u5206\u522b\u8868\u793a\u5728 A \u6a21\u5757\u5185\u90e8\u3001B \u6a21\u5757\u5185\u90e8<\/strong>\uff0c\u4e24\u4e24\u914d\u5bf9\u8282\u70b9\u7684\u5e73\u5747\u6700\u77ed\u8def\u5f84\u957f\u5ea6\u3002S \u503c\u8d8a\u5c0f\uff0c\u76f8\u5173\u6027\u8d8a\u5927\u3002<\/strong><\/span><\/section>\n

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\u7cbe\u51c6\u9884\u6d4b\u5019\u9009\u836f\u7269<\/strong><\/span><\/p>\n

<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

 <\/span><\/p>\n

<\/p>\n

\u8bba\u6587\u7684\u91cd\u5934\u620f\u662f\u9884\u6d4b\u5019\u9009\u836f\u7269\u3002<\/span><\/strong>\u5177\u4f53\u6765\u8bf4\u5c31\u662f\u5bf9\u6240\u6709\u7ecf\u7f8e\u56fd FDA \u6279\u51c6\u7684\u836f\u7269\u6392\u540d\uff0c\u6392\u540d\u9760\u524d\u7684\u662f\u6709\u53ef\u80fd\u5bf9\u6cbb\u7597\u65b0\u51a0\u80ba\u708e\u6709\u6548\u7684\uff0c\u5217\u5165\u5019\u9009\u836f\u7269\u3002\u6587\u7ae0\u7ed9\u51fa\u4e86\u5305\u542b 81 \u4e2a\u5019\u9009\u836f\u7269\u7684\u5217\u8868\uff0c\u89c1\u4e0b\u56fe\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u6240\u6709 5550 \u79cd\u7ecf\u7f8e\u56fdFDA\u6279\u51c6\u7684\u836f\u7269\u4e2d<\/strong>\uff0c\u5f15\u8d77\u5e7f\u6cdb\u8ba8\u8bba\u7684\u201c\u6c2f\u55b9\u201d\u6392\u540d\u7b2c\u4e94<\/strong>\uff0c\u4ece\u4fa7\u9762\u8bc1\u5b9e\u4e86\u9884\u6d4b\u7684\u51c6\u786e\u6027\u3002\u76ee\u524d\uff0c\u79d1\u7814\u56e2\u961f\u5df2\u6839\u636e\u5217\u8868\u8d2d\u4e70\u5019\u9009\u836f\u7269\u5728\u4eba\u4f53\u7ec4\u7ec7\u7ec6\u80de\u4e2d\u8fdb\u884c\u8bd5\u9a8c\u3002\u5bf9\u4e8e\u6548\u679c\u597d\u7684\u5316\u5408\u7269\u540e\u7eed\u5c06\u8fdb\u884c\u4e34\u5e8a\u6d4b\u8bd5\u3002<\/span><\/p>\n


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<\/span><\/section>\n

       <\/span><\/p>\n

\u56fe4\uff1a\u9884\u6d4b\u5f97\u5230\u7684\u5019\u9009\u836f\u7269\u5217\u8868\u3002\u8868\u4e2d\u5305\u542b\u836f\u7269\u540d\u79f0\u548c\u6392\u540d\uff0c\u5e76\u5bf9\u4e00\u4e9b\u5019\u9009\u836f\u7269\u6807\u6ce8\u51fa\u4e86\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6b21\u6570\u548c\u76f8\u5173\u6587\u732e\u4f50\u8bc1\u3002<\/span><\/strong><\/span><\/p>\n

 <\/span><\/p>\n

<\/p>\n

\u5df2\u6709\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u83b7\u6279\u51c6\u4e0a\u5e02\u7684\u836f\u7269\u4e2d\uff0c\u591a\u6570\u5e76\u4e0d\u76f4\u63a5\u4f5c\u7528\u4e8e\u75be\u75c5\u6a21\u5757\u4e2d\u7684\u86cb\u767d\u8d28\uff0c\u800c\u662f\u4e0e\u6a21\u5757\u9644\u8fd1\u7684\u86cb\u767d\u8d28\u7ed3\u5408\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u8ba4\u4e3a\u5019\u9009\u836f\u7269\u7684\u6cbb\u7597\u6a21\u5757\u4e0d\u4e00\u5b9a\u76f4\u63a5\u4f5c\u7528\u4e8e\u75be\u75c5\u6a21\u5757\uff0c<\/strong>\u8fd8\u53ef\u4ee5\u6270\u4e71\u75be\u75c5\u6a21\u5757\u9644\u8fd1\u7684\u7f51\u7edc\u533a\u57df\u3002<\/strong>\u57fa\u4e8e\u8fd9\u4e2a\u601d\u8def\uff0c\u4f5c\u8005\u56e2\u961f\u91c7\u53d6\u4e86\u4e09\u79cd\u7b56\u7565\u9884\u6d4b\u5019\u9009\u836f\u7269\uff1a<\/span><\/p>\n

 <\/span><\/p>\n

    \n
  1. \n

    \u57fa\u4e8e\u7f51\u7edc\u8ddd\u79bb\u7684\u7b56\u7565\uff1a<\/span><\/strong>\u5019\u9009\u836f\u7269\u7684\u6cbb\u7597\u6a21\u5757\u4e0e\u75be\u75c5\u6a21\u5757\u7f51\u7edc\u8ddd\u79bb\u8fd1\uff0c\u89c1\u4e0b\u56fe\u3002<\/span><\/p>\n<\/li>\n

  2. \n

    \u57fa\u4e8e\u7f51\u7edc\u6269\u6563\u7684\u7b56\u7565<\/span>\uff1a<\/span><\/strong>\u5206\u522b\u6270\u52a8\u75be\u75c5\u6a21\u5757\u4e0e\u6cbb\u7597\u6a21\u5757\uff0c\u901a\u8fc7\u89c2\u5bdf\u6269\u6563\u7684\u91cd\u53e0\u6027\u6765\u8861\u91cf<\/span>\u6a21\u5757\u95f4\u7684\u76f8\u4f3c\u5ea6\u3002<\/span>\u5019\u9009\u836f\u7269<\/span>\u7684\u6cbb\u7597\u6a21\u5757\u4e0e\u75be\u75c5\u6a21\u5757<\/span>\u76f8\u4f3c\u5ea6\u9ad8\u3002<\/span><\/p>\n<\/li>\n

  3. \n

    \u57fa\u4e8e\u4eba\u5de5\u667a\u80fd\u7684\u7b56\u7565<\/span>\uff1a<\/span><\/strong>\u4f7f\u7528\u56fe\u795e\u7ecf\u7f51\u7edc\u7684\u65b9\u6cd5\u5c06\u75be\u75c5\u4e0e\u5019\u9009\u836f\u7269\u8fdb\u884c\u5bf9\u5e94\u3002<\/span><\/p>\n<\/li>\n<\/ol>\n

    <\/span><\/section>\n

     <\/p>\n


    <\/p>\n

    <\/section>\n

    \u56fe5\uff1a\u65b0\u51a0\u80ba\u708e\u75be\u75c5\u6a21\u5757\uff08\u7070\u8272\uff09\u4e0e\u6cbb\u7597\u6a21\u5757\u4e4b\u95f4\u5728\u7f51\u7edc\u4e0a\u7684\u8ddd\u79bb\u793a\u610f\u56fe\u3002\u7eff\u8272\u4e3a\u6c2f\u55b9\u6cbb\u7597\u6a21\u5757\uff0c\u6a59\u8272\u4e3a\u4f9d\u90a3\u897f\u666e\uff08\u6cbb\u7597\u5173\u8282\u708e\u836f\u7269\uff09\u6cbb\u7597\u6a21\u5757\u3002<\/span><\/strong><\/span><\/p>\n

     <\/span><\/p>\n

    <\/p>\n

    \u968f\u540e\uff0c\u4f5c\u8005\u5c06\u4e09\u79cd\u7b56\u7565\u5206\u522b\u9884\u6d4b\u51fa\u7684\u7ed3\u679c\u901a\u8fc7\u6392\u540d\u805a\u5408\u7b97\u6cd5\uff08Rank Aggregation Algorithm\uff09\u8fdb\u884c\u878d\u5408\uff0c\u5f97\u5230\u6700\u7ec8\u7ed3\u679c\u3002<\/strong>\u4e3a\u4e86\u8bc4\u4f30\u9884\u6d4b\u7ed3\u679c\u7684\u51c6\u786e\u6027<\/strong>\uff0c\u4f5c\u8005\u5c06\u9884\u6d4b\u7ed3\u679c\u4e0e\u5df2\u77e5\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u7684 67 \u79cd\u836f\u7269\u4f5c\u5bf9\u6bd4\uff0c\u53d1\u73b0\u8fd9 67 \u79cd\u836f\u7269\u6392\u540d\u9760\u524d\uff0c\u9884\u6d4b\u6a21\u578b\u7684 AUROC \u9ad8\u8fbe 0.89<\/strong>\uff08AUROC \u53d6\u503c\u5728 0.5 \u5230 1 \u4e4b\u95f4\uff0c\u8d8a\u63a5\u8fd1 1 \u8d8a\u51c6\u786e\uff09\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fd8\u53d1\u73b0\u5408\u5e76\u540e\u7684\u7ed3\u679c\u8f83\u4e09\u4e2a\u5b50\u6a21\u578b\u7684\u7ed3\u679c\u66f4\u4e3a\u51c6\u786e\u3002<\/span><\/p>\n

     <\/span><\/p>\n

    \u8fd9\u7bc7\u6587\u7ae0\u4ece\u915d\u917f\u5230\u516c\u5e03\u4ec5\u7528\u65f6\u4e24\u4e2a\u6708\u5de6\u53f3\u3002\u8fd9\u4efd\u6210\u679c\u6765\u6e90\u4e8e\u65b0\u51a0\u75ab\u60c5\u7684\u7d27\u8feb\u6027\u548c\u7f51\u7edc\u79d1\u5b66\u5bb6\u4eec\u7684\u8d23\u4efb\u611f<\/strong>\u3002\u6587\u672b\u63d0\u5230\uff1a\u201c\u867d\u7136\u8bba\u6587\u4e2d\u7684\u65b9\u6cd5\u4ecd\u6709\u53ef\u7ee7\u7eed\u6539\u8fdb\u4e4b\u5904\uff0c\u4f46\u662f\u9274\u4e8e\u65b0\u51a0\u75ab\u60c5\u7684\u7d27\u8feb\u6027\u3001\u751f\u7269\u9a8c\u8bc1\u7684\u9700\u6c42\u4ee5\u53ca\u9884\u6d4b\u6a21\u578b\u7684\u9ad8\u51c6\u786e\u5ea6\uff0c\u6211\u4eec\u89c9\u5f97\u9700\u8981\u53ca\u65f6\u62ab\u9732\u7814\u7a76\u7ed3\u679c\uff0c\u4e3a\u540e\u7eed\u7684\u751f\u7269\u8bd5\u9a8c\u4e0e\u4e34\u5e8a\u6d4b\u8bd5\u63d0\u4f9b\u7406\u8bba\u57fa\u7840\u548c\u6307\u5bfc\u3002\u201d<\/span><\/p>\n

     <\/span><\/p>\n


    <\/span><\/p>\n

    \u7f51\u7edc\u533b\u5b66\u76f8\u5173\u6587\u732e\uff1a<\/span><\/strong><\/span><\/p>\n


    <\/span><\/strong><\/span><\/p>\n

    [1] Albert-L\u00e1szl\u00f3 Barab\u00e1si, Natali Gulbahce & Joseph Loscalzo. Network medicine\uff1aa network-based approach to human disease<\/span><\/span><\/p>\n

    [2] J\u00f6rg Menche\uff0cAmitabh Sharma\uff0cMaksim Kitsak\uff0c Susan Dina Ghiassian\uff0cMarc Vidal\uff0cJoseph Loscalzo\uff0c<\/span><\/span>Albert-L\u00e1szl\u00f3 Barab\u00e1si.<\/span> Uncovering disease-disease relationships through the incomplete interactome<\/span><\/span><\/p>\n

    [3] Feixiong Cheng\uff0cRishi J. Desai\uff0cDiane E. Handy\uff0cRuisheng Wang\uff0cSebastian Schneeweiss\uff0cAlbert-L\u00e1szl\u00f3 Barab\u00e1si & Joseph Loscalzo-Show fewer authors. Network-based a<\/span>pproach to prediction and population-based validation of in silico drug repurposing<\/span><\/span><\/p>\n

    <\/span><\/section>\n

    <\/span><\/p>\n

     <\/span><\/p>\n

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    \u4f5c\u8005\uff1a\u5218\u4e16\u5eb7
    <\/p>\n

    \u5ba1\u6821\uff1a\u5218\u57f9\u6e90<\/p>\n

    \u7f16\u8f91\uff1a\u5f20\u723d<\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n


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    \u63a8\u8350\u9605\u8bfb<\/p>\n

    <\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


    <\/p>\n

    \u751f\u7269\u7f51\u7edc | \u96c6\u667a\u767e\u79d1<\/span><\/strong><\/a>
    <\/p>\n

    \u54c8\u4f5b\u5b66\u8005Science\u520a\u6587\uff1a\u793e\u4ea4\u758f\u79bb\u63aa\u65bd\u53ef\u80fd\u8981\u4fdd\u6301\u52302022\u5e74<\/span><\/strong><\/a>
    <\/p>\n

    \u8d85\u8d8aSIR\u6a21\u578b\uff1a\u4fe1\u606f\u4e0e\u75be\u75c5\u4f20\u64ad\u7684\u590d\u6742\u5efa\u6a21<\/span><\/strong><\/a>
    <\/p>\n

    Science&nbsp;\u6700\u65b0\uff1a\u65c5\u884c\u63a7\u5236\u600e\u6837\u5f71\u54cd\u9650\u5236\u65b0\u51a0\u75c5\u6bd2\u7684\u7206\u53d1\u901f\u5ea6\uff1f<\/span><\/strong><\/a>
    <\/p>\n

    \u6269\u6563\u4fe1\u606f\u3001\u4ea4\u901a\u7ba1\u5236\u3001\u81ea\u6211\u9694\u79bb\uff0c\u54ea\u4e2a\u66f4\u80fd\u904f\u5236\u75c5\u6bd2\u4f20\u64ad\uff1f<\/span><\/strong><\/a><\/p>\n

    \u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/span><\/strong><\/a><\/p>\n


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    \u96c6\u667a\u4ff1\u4e50\u90e8QQ\u7fa4\uff5c877391004<\/span><\/strong><\/p>\n

    \u5546\u52a1\u5408\u4f5c\u53ca\u6295\u7a3f\u8f6c\u8f7d\uff5cswarma@swarma.org
    <\/span><\/strong><\/p>\n

    \n

    \u25c6 <\/span>\u25c6 <\/span>\u25c6<\/span><\/span><\/strong><\/strong><\/h1>\n<\/section>\n

    \u641c\u7d22\u516c\u4f17\u53f7\uff1a\u96c6\u667a\u4ff1\u4e50\u90e8<\/span><\/strong><\/span><\/p>\n


    <\/p>\n

    \u52a0\u5165\u201c\u6ca1\u6709\u56f4\u5899\u7684\u7814\u7a76\u6240\u201d<\/span><\/strong><\/span><\/p>\n

    \n

    <\/p>\n<\/section>\n

    \u8ba9\u82f9\u679c\u7838\u5f97\u66f4\u731b\u70c8\u4e9b\u5427\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


    <\/p>\n


    <\/p>\n

    \ud83d\udc47\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u4e86\u89e3\u66f4\u591a\u8bba\u6587\u4fe1\u606f<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

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