{"id":19514,"date":"2020-05-06T21:08:10","date_gmt":"2020-05-06T13:08:10","guid":{"rendered":"https:\/\/swarma.org\/?p=19514"},"modified":"2020-05-06T21:08:10","modified_gmt":"2020-05-06T13:08:10","slug":"science%e7%bb%8f%e5%85%b8%ef%bc%9a%e5%a4%8d%e6%9d%82%e7%bd%91%e7%bb%9c%e7%9a%84%e7%ae%80%e5%8d%95%e6%9e%84%e9%80%a0%e6%a8%a1%e5%9d%97-%e7%bd%91%e7%bb%9c%e6%a8%a1%e4%bd%93","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=19514","title":{"rendered":"Science\u7ecf\u5178\uff1a\u590d\u6742\u7f51\u7edc\u7684\u7b80\u5355\u6784\u9020\u6a21\u5757\u2014\u2014\u7f51\u7edc\u6a21\u4f53"},"content":{"rendered":"
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Network Motifs: simple Building blocks of Complex Networks<\/span><\/section>\n
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https:\/\/science.sciencemag.org\/content\/298\/5594\/824<\/span><\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n


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1. \u6a21\u4f53\uff1a<\/strong><\/span><\/p>\n

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2. \u6a21\u4f53\u7684\u666e\u904d\u4e0e\u8de8\u5b66\u79d1\u6027<\/strong><\/span><\/p>\n

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3. \u5982\u4f55\u68c0\u6d4b\u6a21\u4f53\u7684\u5b58\u5728<\/strong><\/span><\/p>\n

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4. \u4e86\u89e3\u5e38\u89c1\u7684\u6a21\u4f53\uff0c<\/strong><\/span><\/p>\n

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\u5728 2002 \u5e74\u8fd9\u7bc7 Science \u8bba\u6587\u4e2d\uff0c\u4f5c\u8005\u7ed9\u51fa\u4e86\u4e00\u7ec4\u5728\u591a\u79cd\u80cc\u666f\u4e2d\u90fd\u4f1a\u51fa\u73b0\u7684\u7f51\u7edc\u6a21\u4f53\uff0c\u4f8b\u5982\uff1a<\/span><\/section>\n

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\u5728\u793e\u4ea4\u7f51\u7edc\u4e2d\uff0c\u4e0a\u8ff0\u7684\u6a21\u4f53\uff0c\u4f3c\u4e4e\u53e4\u4eba\u65e9\u5df2\u53d1\u73b0\u3002\u4f8b\u5982 Three chain\uff0c\u53ef\u4ee5\u770b\u6210\u662f\u87b3\u8782\u6355\u9ec4\u96c0\u5728\u540e\uff1b\u800c Feed forward loop \u5bf9\u5e94\u9694\u5c71\u6253\u725b\uff1bThree-node feedback loop \u5bf9\u5e94\u56e0\u7978\u5f97\u798f\u7978\u798f\u76f8\u501a\u3002\u900f\u8fc7\u4e0d\u540c\u793e\u4ea4\u7f51\u7edc\u4e2d\u51fa\u73b0\u7684\u4e0d\u540c\u7c7b\u578b\u7684\u6a21\u4f53\uff0c\u53ef\u4ee5\u5224\u65ad\u7f51\u7edc\u5bf9\u5e94\u7ec4\u7ec7\u7684\u6587\u5316\uff0c\u4f8b\u5982\u4e00\u4e2a\u4eba\u9645\u7f51\u7edc\u4e2d\uff0c\u7ecf\u5e38\u51fa\u73b0 X \u5236\u7ea6 Y\uff0cY \u9632\u8303 Z\uff0c\u800c Z \u53c8\u62ff\u7740 X \u7684\u5c0f\u8fab\u5b50\u7684\u60c5\u51b5\uff0c\u8fd9\u6837\u7684\u7f51\u7edc\u4e2d\u5bf9\u5e94\u7684 Three-node feedback loop \u6a21\u4f53\u610f\u5473\u7740\u8fd9\u6837\u7684\u7ec4\u7ec7\u4e2d\u4eba\u9645\u5173\u7cfb\u590d\u6742\uff0c\u76f8\u4e92\u9632\u8303\uff0c\u4e0d\u662f\u4e00\u4e2a\u9002\u5408\u5fc3\u601d\u5355\u7eaf\u8005\u7684\u73af\u5883\u3002<\/span><\/section>\n


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5. \u6a21\u4f53\u5728\u590d\u6742\u7f51\u7edc\u4e2d\u7684\u5e94\u7528<\/strong><\/span><\/p>\n

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\u590d\u6742\u7f51\u7edc\u7684\u4e00\u5927\u6d8c\u73b0\u6027\u4f53\u73b0\u5728\u5176\u540c\u65f6\u5177\u6709\u8106\u5f31\u6027\uff08\u9762\u5bf9\u7279\u5b9a\u653b\u51fb\uff09\u548c\u9c81\u68d2\u6027\uff08\u9762\u5bf9\u4e00\u822c\u653b\u51fb\u65f6\u7684\u6062\u590d\u80fd\u529b\uff09\uff0c\u5728[1]\u4e2d\uff0c\u901a\u8fc7\u5bf9\u6b27\u6d32\u4e0d\u540c\u56fd\u5bb6\u7535\u7f51\u7684\u5206\u6790\uff0c\u627e\u5230\u4e86\u7279\u5b9a\u6a21\u4f53\u51fa\u73b0\u9891\u7387\u548c\u7535\u7f51\u9762\u5bf9\u653b\u51fb\uff08\u8282\u70b9\u88ab\u5220\u9664\uff09\u65f6\u7684\u6062\u590d\u80fd\u529b\u5b58\u5728\u76f8\u5173\u6027\uff0c\u4ece\u800c\u901a\u8fc7\u57fa\u4e8e\u6a21\u4f53\u7684\u5206\u6790\uff0c\u5224\u5b9a\u5fb7\u56fd\u548c\u610f\u5927\u5229\u7535\u7f51\u76f8\u6bd4\u6cd5\u56fd\u548c\u897f\u73ed\u7259\u7684\u66f4\u53ef\u9760\u3002<\/span><\/section>\n


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19\u5e74\u7684\u7efc\u8ff0\u201cNetwork Motifs: A Survey\u201d[2]\u4e2d\uff0c\u6982\u8ff0\u4e86\u6a21\u4f53\u5728\u5177\u4f53\u573a\u666f\u4e0b\u7684\u5e94\u7528\u3002\u9996\u5148\u5728\u751f\u7269\u5b66\u7f51\u7edc\u4e2d\uff0c\u4f8b\u5982\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\uff0c\u53ef\u901a\u8fc7\u6a21\u4f53\u9884\u6d4b\u86cb\u767d\u8d28\u95f4\u7684\u76f8\u4e92\u4f5c\u7528[3]\uff0c\u6216\u86cb\u767d\u8d28\u5728\u7f51\u7edc\u4e2d\u7684\u529f\u80fd[4]\u3002\u5728\u901a\u8fc7\u65f6\u7a7a\u7f51\u7edc\uff08Spatio temporal Network\uff09<\/strong>\u5bf9\u751f\u7269\u4f53\u7684\u7279\u5f81\u5efa\u6a21\u65f6\uff0c\u7f51\u7edc\u4e2d\u6a21\u4f53\u7684\u5b58\u5728\uff0c\u53ef\u4ee5\u5e2e\u52a9\u7406\u89e3\u751f\u7269\u4f53\u53d1\u80b2\u8fc7\u7a0b\u4e2d\uff0c\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u5982\u4f55\u53d1\u6325\u4f5c\u7528[5]\u3002\u5728\u4eba\u4f53\u5185\u751f\u7269\u4fe1\u53f7\u95f4\u7684\u4f20\u5bfc\u7f51\u7edc\u4e2d\uff0c\u901a\u8fc7\u627e\u5230\u7279\u5b9a\u7684\u6a21\u4f53\uff0c\u53ef\u4ee5\u4e3a\u4e73\u817a\u764c\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u63d0\u4f9b\u52a9\u529b[6]\u3002\u5728\u4eba\u9645\u4ea4\u6d41\u7f51\u7edc\u6570\u636e\u7ec4\u6210\u7684\u65f6\u5e8f\u7f51\u7edc\u4e2d\uff0c\u901a\u8fc7\u8bc6\u522b\u6a21\u4f53\uff0c\u53ef\u4ee5\u627e\u5230\u7537\u6027\u4e0e\u5973\u6027\u4ea4\u6d41\u65b9\u5f0f\u7684\u5dee\u5f02\u6027\uff0c\u5e76\u627e\u5230\u7f51\u7edc\u4e2d\u5c40\u90e8\u4e2d\u7684\u5c40\u90e8\u7684\u5747\u4e00\u6027[7]\uff0c\u901a\u8fc7\u8bc6\u522b\u4e0d\u540c\u7684\u6a21\u4f53\uff0c\u53ef\u4ee5\u7814\u7a76\u5fae\u535a\u4e2d\u4fe1\u606f\u6d41\u5728\u5904\u5728\u4f20\u64ad\u8fc7\u7a0b\u4e2d\u7684\u90a3\u4e2a\u9636\u6bb5[8]\u3002\u901a\u8fc7\u8bc6\u522b\u6a21\u4f53\uff0c\u8fd8\u53ef\u4ee5\u4f18\u5316\u65e0\u4eba\u9a7e\u9a76\u6c7d\u8f66\u4e4b\u95f4\u7684\u4fe1\u53f7\u4ea4\u6d41\u7f51\u7edc\uff0c\u51cf\u5c11\u5ef6\u8fdf[9]\u7b49\u3002<\/span><\/section>\n

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\u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
Network Motifs: A Survey<\/span><\/section>\n
\u8bba\u6587\u5730\u5740\uff1a<\/span><\/section>\n
https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-9942-8_8<\/span><\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n


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6. \u6a21\u4f53\u76f8\u5173\u7814\u7a76\u7684\u8fdb\u5c55\u4e0e\u65b9\u5411<\/strong><\/span><\/p>\n

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\u6a21\u4f53\u76f8\u5173\u7684\u524d\u6cbf\u7814\u7a76\uff0c\u4e00\u4e2a\u65b9\u5411\u662f\u627e\u51fa\u66f4\u5feb\u6377\u7684\u7b97\u6cd5\uff0c\u6765\u8bc6\u522b\u6a21\u4f53\uff0c\u5c24\u5176\u662f\u5728\u5305\u542b\u6d77\u91cf\u8282\u70b9\u7684\u7f51\u7edc\u4e2d\uff0c\u4f7f\u7528 GPU\uff0c\u8bc6\u522b\u51fa\u5305\u542b\u66f4\u591a\u8282\u70b9\u7684\u6a21\u4f53\uff08\u5f53\u6a21\u4f53\u5305\u542b\u7684\u8282\u70b9\u589e\u52a0\uff0c\u8bc6\u522b\u6a21\u4f53\u6240\u9700\u7684\u65f6\u95f4\u548c\u5b58\u50a8\u90fd\u4f1a\u6307\u6570\u7ea7\u589e\u52a0\uff09\u3002<\/span><\/section>\n


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\u7b2c\u4e8c\u4e2a\u65b9\u5411\u662f\u5728\u5927\u89c4\u6a21\u65f6\u95f4\u5e8f\u5217\u7f51\u7edc\u4e2d\uff0c\u5feb\u901f\u8bc6\u522b\u51fa\u4e00\u7ec4\u76f8\u8fd1\u7684\u6a21\u4f53\u3002<\/span><\/section>\n


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\u7b2c\u4e09\u4e2a\u65b9\u5411\u662f\u5982\u4f55\u5728\u591a\u5c42\u7f51\u7edc\uff0c\u6216\u8d85\u56fe\u4e2d\u5b9a\u4e49\u51fa\u7c7b\u4f3c\u6a21\u4f53\u8fd9\u6837\u7684\u5c40\u90e8\u7ed3\u6784\uff0c\u4ece\u800c\u5c06\u6a21\u4f53\u7684\u5206\u6790\u6269\u5c55\u5230\u9ad8\u9636\u7f51\u7edc\uff0c\u5bf9\u4e8e\u8be5\u95ee\u9898\uff0c\u53ef\u4ee5\u53c2\u8003[10]\uff0c\u6587\u4e2d\u5bf9\u591a\u5c42\u6a21\u4f53\u7ed9\u51fa\u4e86\u5f62\u5f0f\u5316\u7684\u5b9a\u4e49\uff0c\u5e76\u901a\u8fc7\u5bf9\u771f\u5b9e\u591a\u5c42\u7f51\u7edc\u7684\u5206\u6790\uff0c\u5f97\u51fa\u591a\u5c42\u7f51\u7edc\u4e2d\u7684\u6a21\u4f53\u5728\u4e0d\u540c\u5c42\u6b21\u4e0a\u7684\u540c\u8d28\u6027\u3002<\/span><\/section>\n

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\u5728\u9ad8\u9636\u7f51\u7edc\u4e0a\uff0c\u57fa\u4e8e\u6a21\u4f53\u53ef\u4ee5\u5bf9\u7f51\u7edc\u8fdb\u884c\u805a\u7c7b\uff0c\u5e76\u5c06\u8de8\u8d8a\u7f51\u7edc\u4e0d\u540c\u5c42\u7684\u6a21\u4f53\u5b9a\u4e49\u4e3a\u6a21\u4f53\u5207\u5272\uff0c\u4ece\u800c\u5b9a\u4e49\u51fa\u56fe\u5143\uff08graphlets\uff09\u7684\u9ad8\u9636\u63cf\u8ff0\u7b26\uff0c\u5c06\u5c40\u90e8\u8fde\u63a5\u6a21\u5f0f \uff08local wiring patterning\uff09\u4e0e\u7531\u5176\u6240\u5904\u7684\u9ad8\u9636\u7ed3\u6784\u6a21\u5757\u5316\u7ed3\u5408\u8d77\u6765[11]\uff0c\u7531\u6b64\u7531\u6a21\u4f53\u51fa\u53d1\u5b9a\u4e49\u51fa\u63cf\u8ff0\u9ad8\u9636\u7f51\u7edc\u5c40\u90e8\u7ed3\u6784\u7684\u65b0\u7684\u6982\u5ff5\u3002<\/span><\/section>\n

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\u53c2\u8003\u6587\u732e\uff1a<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n

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[1] What network motifs tell us about resilience and reliability of complex networks. https:\/\/www.pnas.org\/content\/116\/39\/19368<\/span><\/span><\/section>\n
[2] Network Motifs: A Survey<\/span>.<\/span><\/section>\n
https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-9942-8_8<\/span><\/section>\n
[3] Labeling network motifs in protein interactomes for protein function prediction. https:\/\/ieeexplore.ieee.org\/document\/4221703<\/span><\/section>\n
[4] Graph mining of motif profiles for computer network activity inference. https:\/\/www.cs.purdue.edu\/mlg2011\/papers\/paper_16.pdf<\/span><\/section>\n
[5] Spatiotemporal network motif reveals the biological traits of developmental gene regulatory networks in drosophila melanogaster. https:\/\/bmcsystbiol.biomedcentral.com\/articles\/10.1186\/1752-0509-6-31<\/span><\/section>\n
[6] Identification of breast cancer patients based on human signaling network motifs. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3842546\/<\/span><\/section>\n
[7] Temporal motifs reveal homophily, gender-specific patterns, and group talk in call sequences. https:\/\/www.pnas.org\/content\/110\/45\/18070<\/span><\/section>\n
[8] <\/span>Understanding Information Flow in Cascades Using Network Motifs. http:\/\/arxiv.org\/abs\/1904.05161<\/span> <\/span>
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[9] Spatio-temporal motifs for optimized vehicle-to-vehicle(v2v) communications. <\/span>https:\/\/arxiv.org\/abs\/1711.06306<\/span><\/span><\/section>\n
[10] Analysing Motifs in Multilayer Networks. <\/span>http:\/\/arxiv.org\/abs\/1903.01722<\/span><\/section>\n
[11] <\/span>Full Higher-order organization of complex networks<\/span>. https:\/\/science.sciencemag.org\/content\/353\/6295\/163.<\/span>
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\u590d\u6742\u7f51\u7edc\u4e0a\u7684\u7206\u53d1\u73b0\u8c61\u7efc\u8ff0\uff1a\u76f8\u53d8\u3001\u7206\u53d1\u3001\u751f\u547d\u8d77\u6e90\u6709\u4f55\u5171\u540c\u4e4b\u5904<\/span><\/strong><\/a>
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Nature \u901a\u8baf\uff1a\u590d\u6742\u7f51\u7edc\u5982\u4f55\u5316\u7e41\u4e3a\u7b80?<\/span><\/strong><\/a>
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\u590d\u6742\u7f51\u7edc\u5347\u9636\u6307\u5357\uff1a\u5982\u4f55\u6784\u5efa\u6700\u4f18\u7f51\u7edc\u6a21\u578b<\/span><\/strong><\/a>
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\u53ec\u5524\u70ed\u7231\u79d1\u5b66\uff0c\u4e50\u4e8e\u63a2\u7d22\u7684\u4f60 | 2020 \u96c6\u667a\u4ff1\u4e50\u90e8\u5fd7\u613f\u8005\u62db\u65b0<\/span><\/span><\/strong><\/a>
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\u5546\u52a1\u5408\u4f5c\u53ca\u6295\u7a3f\u8f6c\u8f7d\uff5cswarma@swarma.org
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\u25c6 <\/span>\u25c6 <\/span>\u25c6<\/span><\/span><\/strong><\/strong><\/h1>\n<\/section>\n

\u641c\u7d22\u516c\u4f17\u53f7\uff1a\u96c6\u667a\u4ff1\u4e50\u90e8<\/span><\/strong><\/span><\/p>\n


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\u52a0\u5165\u201c\u6ca1\u6709\u56f4\u5899\u7684\u7814\u7a76\u6240\u201d<\/span><\/strong><\/span><\/p>\n

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\u8ba9\u82f9\u679c\u7838\u5f97\u66f4\u731b\u70c8\u4e9b\u5427\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\ud83d\udc47\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u4e86\u89e3\u66f4\u591a\u8bba\u6587\u4fe1\u606f<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bfc\u8bed \u6a21\u4f53\uff08motif\uff09\u662f\u4e00\u4e2a\u5bf9\u521d\u6d89\u590d\u6742\u79d1\u5b66\u7684\u4eba\u6765\u8bf4\uff0c\u76f8\u5bf9\u964c\u751f\u7684\u6982\u5ff5\uff0c\u4f46\u5b83\u5374\u662f\u590d\u6742\u7f51\u7edc\u7814\u7a76\u4e2d\u6700\u6709\u529b\u7684\u5de5\u5177\u4e4b\u4e00\u30022002\u5e74\u7684 Science \u8bba\u6587\u201cNetwork Motifs: simple Building blocks of Complex Networks\u201d\u4ecb\u7ecd\u4e86\u6a21\u4f53\u7684\u6982\u5ff5\uff0c\u81f3\u4eca\u5f15\u7528\u6b21\u6570\u5df2\u6709 …<\/p>\n","protected":false},"author":1,"featured_media":19505,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/19514"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19514"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/19514\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/19505"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19514"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19514"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19514"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=19514"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}