{"id":19649,"date":"2020-05-14T17:18:38","date_gmt":"2020-05-14T09:18:38","guid":{"rendered":"https:\/\/swarma.org\/?p=19649"},"modified":"2020-05-14T17:18:38","modified_gmt":"2020-05-14T09:18:38","slug":"physics-reports%e8%ae%a1%e7%ae%97%e7%bd%91%e7%bb%9c%e7%94%9f%e7%89%a9%e5%ad%a6%e9%95%bf%e6%96%87%e7%bb%bc%e8%bf%b0%ef%bc%9a%e6%95%b0%e6%8d%ae%e3%80%81%e6%a8%a1%e5%9e%8b%e5%92%8c%e5%ba%94%e7%94%a8","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=19649","title":{"rendered":"Physics Reports\u8ba1\u7b97\u7f51\u7edc\u751f\u7269\u5b66\u957f\u6587\u7efc\u8ff0\uff1a\u6570\u636e\u3001\u6a21\u578b\u548c\u5e94\u7528"},"content":{"rendered":"
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Computational network biology: Data, models, and applications<\/span><\/h1>\n
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https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0370157319304041<\/span><\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n


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1. \u7f51\u7edc\u7ed3\u6784\u4e0e\u751f\u7269\u529f\u80fd<\/strong><\/span><\/p>\n

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\u751f\u7269\u7f51\u7edc\u7ed3\u6784\u590d\u6742\uff0c\u5bf9\u751f\u7269\u7f51\u7edc\u7ed3\u6784\u7684\u5206\u6790\uff0c\u6709\u52a9\u4e8e\u6211\u4eec\u66f4\u597d\u7684\u7406\u89e3\u751f\u7269\u529f\u80fd\u3002\u751f\u7269\u7f51\u7edc\u5177\u6709\u5f88\u5f3a\u7684\u5f02\u8d28\u6027\uff0c\u7f51\u7edc\u5ea6\u5206\u5e03\u5927\u591a\u5448\u73b0\u5e42\u5f8b\u5206\u5e03\u7279\u5f81\u3002Jeong \u7b49[2]\u5728\u86cb\u767d-\u86cb\u767d\u7f51\u7edc\u4e2d\u53d1\u73b0\u7684\u4e2d\u5fc3\u6027-\u81f4\u6b7b\u7387\u51c6\u5219\uff08Centrality-Lethality Rule\uff09<\/strong>\uff0c\u5373\u86cb\u767d\u8d28\u7684\u91cd\u8981\u6027\u4e0e\u5176\u5728\u86cb\u767d-\u86cb\u767d\u7f51\u7edc\u4e2d\u7684\u4e2d\u5fc3\u6027\u9ad8\u5ea6\u76f8\u5173\uff0c\u7c7b\u4f3c\u7684\u53d1\u73b0\u4e5f\u5728\u591a\u79cd\u751f\u7269\u5206\u5b50\u7f51\u7edc\u4e2d\u88ab\u8bc1\u5b9e\u3002<\/span><\/p>\n


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2. \u5173\u952e\u751f\u7269\u5206\u5b50\u8bc6\u522b<\/strong><\/span><\/p>\n

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\u5728\u7f51\u7edc\u5206\u6790\u4e2d\uff0c\u7f51\u7edc\u4e2d\u5fc3\u6027\u662f\u523b\u753b\u8282\u70b9\u91cd\u8981\u6027\u7684\u5173\u952e\u6307\u6807\uff0c\u8be5\u5047\u8bbe\u5728\u751f\u7269\u7f51\u7edc\u4e2d\u540c\u6837\u9002\u7528\u3002\u7f51\u7edc\u4e2d\u5fc3\u6027\u8f83\u9ad8\u7684\u751f\u7269\u5206\u5b50\u901a\u5e38\u90fd\u4e0e\u75be\u75c5\u53d1\u751f\u3001\u836f\u7269\u9776\u70b9\u7b49\u76f8\u5173 [4]\u3002\u5728\u751f\u7269\u7f51\u7edc\u4e2d\uff0c\u901a\u5e38\u5355\u4e2a\u57fa\u56e0\u7a81\u53d8\u53ef\u4ee5\u901a\u8fc7\u7f51\u7edc\u4f20\u64ad\u6765\u653e\u5927\u7a81\u53d8\u4fe1\u53f7\uff0c\u8fdb\u800c\u6270\u52a8\u6574\u4e2a\u901a\u8def\u5bfc\u81f4\u75be\u75c5\u53d1\u751f[5]\u3002\u56e0\u6b64\uff0c\u7f51\u7edc\u4f20\u64ad\uff0c\u5c24\u5176\u662f\u5e26\u91cd\u542f\u7684\u968f\u673a\u6e38\u8d70\u65b9\u6cd5\uff08Random Walk with Restart\uff09\uff0c\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5173\u952e\u751f\u7269\u5206\u5b50\u7684\u9884\u6d4b\u3002\u4f8b\u5982\uff0c\u5728\u75be\u75c5\u57fa\u56e0\u9884\u6d4b\u4e2d\uff0c\u7ed9\u5df2\u77e5\u75be\u75c5\u57fa\u56e0\u8d4b\u4e88\u4e00\u5b9a\u7684\u5206\u6570\uff0c\u7136\u540e\u91c7\u7528\u7f51\u7edc\u4f20\u64ad\u7684\u65b9\u6cd5\uff0c\u5728\u7cfb\u7edf\u8fbe\u5230\u7a33\u6001\u65f6\uff0c\u5206\u6570\u8f83\u9ad8\u7684\u57fa\u56e0\u4e5f\u662f\u76f8\u5e94\u7684\u75be\u75c5\u57fa\u56e0\u7684\u6982\u7387\u8f83\u9ad8 [6]\u3002Leiserson \u7b49\u63d0\u51fa\u7684 HotNet \u65b9\u6cd5\u5229\u7528\u80bf\u7624\u75c5\u4eba\u7684\u57fa\u56e0\u7a81\u53d8\u4fe1\u53f7\u5728\u7f51\u7edc\u4e2d\u7684\u4f20\u64ad\u6765\u8bc6\u522b\u80bf\u7624\u7684\u9a71\u52a8\u57fa\u56e0\uff0c\u7b97\u6cd5\u53d1\u73b0\u4e86\u4e00\u4e9b\u7f55\u89c1\u7a81\u53d8\u7684\u80bf\u7624\u9a71\u52a8\u57fa\u56e0[7]\u3002\u6b64\u5916\uff0c\u7f51\u7edc\u4f20\u64ad\u65b9\u6cd5\u4e5f\u53ef\u4ee5\u7528\u4e8e\u5f25\u8865\u751f\u7269\u4e34\u5e8a\u6570\u636e\u7684\u7a00\u758f\u6027\uff0c\u4e3a\u6df1\u5165\u5206\u6790\u63d0\u4f9b\u66f4\u5e73\u6ed1\u7684\u6570\u636e[8]\u3002<\/span><\/p>\n


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\u7f51\u7edc\u7ed3\u6784\u53ef\u63a7\u6027\u5206\u6790\u4e5f\u6709\u52a9\u4e8e\u8bc6\u522b\u5173\u952e\u751f\u7269\u5206\u5b50\u3002Vinayagam \u7b49\u57fa\u4e8e\u7f51\u7edc\u53ef\u63a7\u6027\u5f97\u5230\u4e86\u86cb\u767d-\u86cb\u767d\u7f51\u7edc\u7684\u4e0d\u53ef\u6216\u7f3a\u8282\u70b9\u96c6\uff08Indispensable\uff09\uff0c\u5373\u5220\u9664\u8fd9\u4e9b\u8282\u70b9\u4f1a\u5bfc\u81f4\u63a7\u5236\u8282\u70b9\u4e2a\u6570\u589e\u52a0\uff0c\u8fd9\u4e9b\u4e0d\u53ef\u6216\u7f3a\u8282\u70b9\u90fd\u662f\u5e38\u89c1\u7684\u81f4\u75c5\u7a81\u53d8\u6216\u8005\u4eba\u7c7b\u75c5\u6bd2\u7684\u76ee\u6807\u86cb\u767d\u548c\u4e00\u4e9b\u5df2\u77e5\u7684\u836f\u7269\u9776\u6807[9]\u3002Wuchty \u901a\u8fc7\u6700\u5c0f\u652f\u914d\u70b9\u96c6\u7684\u65b9\u6cd5\u627e\u5230\u7f51\u7edc\u7684\u63a7\u5236\u86cb\u767d\uff0c\u53d1\u73b0\u8fd9\u4e9b\u86cb\u767d\u4e0d\u4ec5\u5177\u6709\u91cd\u8981\u7684\u529f\u80fd\uff08\u5982\u764c\u75c7\u76f8\u5173\u86cb\u767d\u3001\u75c5\u6bd2\u76ee\u6807\u86cb\u767d\u7b49\uff09\uff0c\u800c\u4e14\u5728\u7f51\u7edc\u4fe1\u53f7\u63a7\u5236\u4e2d\u4e5f\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff08\u5982\u8f6c\u5f55\u56e0\u5b50\u3001\u6fc0\u9176\u86cb\u767d\uff09[10]\u3002\u6b64\u5916\uff0c\u57fa\u4e8e\u751f\u7269\u5b9e\u9a8c\u7684\u7814\u7a76\u7ed3\u679c\u4e5f\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u7f51\u7edc\u63a7\u5236\u5728\u5173\u952e\u751f\u7269\u5206\u5b50\u8bc6\u522b\u4e2d\u7684\u4f5c\u7528 [11]\u3002<\/span><\/p>\n

 <\/span><\/p>\n


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3. \u7f51\u7edc\u75be\u75c5<\/strong><\/span><\/p>\n

<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u75be\u75c5\u901a\u5e38\u5f88\u5c11\u662f\u7531\u4e8e\u5355\u4e2a\u57fa\u56e0\u5f02\u5e38\uff0c\u800c\u662f\u7ec4\u7ec7\u548c\u5668\u5b98\u7cfb\u7edf\u7684\u590d\u6742\u751f\u7269\u7f51\u7edc\u7684\u6270\u52a8\u6216\u6545\u969c[12]\u800c\u5f15\u8d77\u7684\u3002\u7f51\u7edc\u533b\u5b66\u7684\u5047\u8bbe\u8ba4\u4e3a\uff0c\u57fa\u56e0\u53d8\u5f02\uff08\u5305\u62ec\u6269\u589e\u3001\u7f3a\u5931\u3001\u79fb\u4f4d\u548c\u7a81\u53d8\u7b49\uff09\u5bfc\u81f4\u751f\u7269\u5206\u5b50\u7f51\u7edc\u53d1\u751f\u6270\u52a8\uff0c\u8fdb\u800c\u4f7f\u5f97\u7f51\u7edc\u6027\u8d28\u548c\u7cfb\u7edf\u72b6\u6001\u53d1\u751f\u6539\u53d8\uff0c\u800c\u5bfc\u81f4\u75be\u75c5\u7684\u53d1\u751f\u53d1\u5c55\u7ef4\u6301\u548c\u6076\u5316[12]\u3002\u8fd9\u4e00\u5047\u8bbe\u4e5f\u88ab\u529f\u80fd\u5b66\u7814\u7a76\u6240\u8bc1\u5b9e\uff0c\u75be\u75c5\u76f8\u5173\u7684\u7b49\u4f4d\u57fa\u56e0\u53d8\u5f02\u901a\u5e38\u6539\u53d8\u7684\u662f\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\uff0c\u800c\u4e0d\u662f\u86cb\u767d\u8d28\u7684\u6298\u53e0\u548c\u7a33\u5b9a\u6027[13]\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u56e0\u6b64\uff0c\u5927\u591a\u6570\u75be\u75c5\u66f4\u5e94\u8be5\u88ab\u63cf\u8ff0\u4e3a\u201c\u7f51\u7edc\u75be\u75c5\u201d\u3002\u5728\u8fd9\u4e2a\u5c42\u9762\u4e0a\u8bf4\uff0c\u57fa\u4e8e\u8fb9\u7a81\u53d8\uff08Edgetic mutation\uff09<\/strong>[13]\u548c\u7f51\u7edc\u7a81\u53d8\uff08Network-attacking mutation\uff09<\/strong>[14]\u7684\u63cf\u8ff0\u8303\u5f0f\uff0c\u66f4\u6709\u52a9\u4e8e\u4ece\u4eba\u7c7b\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u7684\u751f\u7269\u5206\u5b50\u6c34\u5e73\u66f4\u597d\u5730\u8bc4\u4f30\u4eba\u7c7b\u75be\u75c5\u7684\u5185\u5728\u590d\u6742\u6027\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5bf9\u4e8e\u75be\u75c5\u86cb\u767d\u7684\u7814\u7a76\u8868\u660e\uff0c\u75be\u75c5\u86cb\u767d\u4e4b\u95f4\u66f4\u503e\u5411\u4e8e\u5f62\u6210\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\uff0c\u7f16\u8f91\u8fd9\u7ec4\u86cb\u767d\u7684\u57fa\u56e0\u4e5f\u66f4\u503e\u5411\u4e8e\u5728\u7279\u5b9a\u7684\u7ec4\u7ec7\u4e2d\u5171\u8868\u8fbe[15]\u3002\u56e0\u6b64\uff0c\u75be\u75c5\u86cb\u767d\u5e76\u4e0d\u662f\u968f\u673a\u7684\u5206\u5e03\u5728\u86cb\u767d-\u86cb\u767d\u7f51\u7edc\u4e2d\uff0c\u800c\u662f\u4f1a\u76f8\u4e92\u4e4b\u95f4\u8fde\u63a5\u5f62\u6210\u4e00\u4e2a\u6216\u51e0\u4e2a\u5b50\u7f51\u7edc\uff0c\u8fd9\u88ab\u5b9a\u4e49\u4e3a\u75be\u75c5\u6a21\u5757\uff08\u5982\u56fe2\u6240\u793a\uff09\u3002Menche \u7b49\u7814\u7a76\u4e86 299 \u79cd\u75be\u75c5\uff0c\u901a\u8fc7\u6700\u5927\u8fde\u901a\u5b50\u96c6\u548c\u75be\u75c5\u76f4\u5f84\uff08\u6bcf\u4e2a\u75be\u75c5\u86cb\u767d\u5230\u4e0e\u5176\u8ddd\u79bb\u6700\u8fd1\u7684\u75be\u75c5\u86cb\u767d\u4e4b\u95f4\u7684\u8ddd\u79bb\u7684\u5e73\u5747\u503c\uff09\u7684\u5206\u6790\u53d1\u73b0\u5176\u4e2d 226 \u79cd\u75be\u75c5\u86cb\u767d\u663e\u8457\u503e\u5411\u4e8e\u5f62\u6210\u75be\u75c5\u6a21\u5757\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u75be\u75c5\u6a21\u5757\u7684\u53d1\u73b0\u4e0d\u4ec5\u6709\u52a9\u4e8e\u4ece\u7cfb\u7edf\u6027\u7684\u89c6\u89d2\u7406\u89e3\u75be\u75c5\u53d1\u751f\u53d1\u5c55\uff0c\u4e5f\u80fd\u591f\u4fc3\u8fdb\u75be\u75c5\u836f\u7269\u7684\u7814\u53d1\u3002\u57fa\u4e8e\u7f51\u7edc\u7684\u8ba1\u7b97\u7814\u7a76\u4e3a\u75be\u75c5\u6a21\u5757\u6316\u6398\u63d0\u4f9b\u4e86\u5927\u91cf\u7684\u65b9\u6cd5[16]\uff0c\u6309\u7167\u6570\u636e\u573a\u666f\u5927\u81f4\u53ef\u4ee5\u5206\u4e3a\u4e24\u7c7b\uff1a\uff081\uff09\u57fa\u4e8e\u5df2\u77e5\u7684\u75be\u75c5\u57fa\u56e0\uff0c\u5bfb\u627e\u7f51\u7edc\u4e2d\u6700\u6709\u53ef\u80fd\u4e0e\u5176\u6784\u6210\u6a21\u5757\u7684\u57fa\u56e0\u96c6\uff0c\u8fdb\u800c\u5f62\u6210\u75be\u75c5\u6a21\u5757[17]\uff1b\uff082\uff09\u6574\u5408\u751f\u7269\u7f51\u7edc\u6570\u636e\u548c\u75be\u75c5\u76f8\u5173\u7684\u57fa\u56e0\u7ec4\u5b66\u6570\u636e\uff0c\u5305\u62ec\u5dee\u5f02\u8868\u8fbe\u3001\u7a81\u53d8\u5e8f\u5217\u7b49\uff0c\u5b9a\u4e49\u76f8\u5e94\u7684\u76ee\u6807\u51fd\u6570\uff0c\u91c7\u7528\u7f51\u7edc\u641c\u7d22\u7684\u65b9\u6cd5\u5bfb\u627e\u75be\u75c5\u6a21\u5757[18]\u3002<\/span><\/p>\n

 <\/span><\/p>\n

<\/section>\n
\u56fe2\uff1a\u75be\u75c5\u6a21\u5757\u793a\u610f\u56fe[16]<\/span><\/strong><\/span>
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 <\/span><\/p>\n

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4. \u57fa\u4e8e\u836f\u7269-\u57fa\u56e0-\u75be\u75c5<\/strong><\/span><\/p>\n

\u7f51\u7edc\u7684\u836f\u7269\u7814\u53d1<\/strong><\/span><\/p>\n

<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u867d\u7136\u6700\u8fd1\u51e0\u5341\u5e74\u751f\u7269\u533b\u5b66\u548c\u5236\u836f\u5b66\u7684\u7814\u7a76\u53d6\u5f97\u4e86\u957f\u8db3\u7684\u53d1\u5c55\uff0c\u4f46\u662f\u6bcf\u5e74\u65b0\u589e\u7684\u88ab FDA \u8ba4\u8bc1\u7684\u836f\u7269\u6cbb\u7597\u65b9\u6848\u4f9d\u7136\u975e\u5e38\u6709\u9650\uff0c\u5176\u4e2d\u4e00\u4e2a\u4e3b\u8981\u539f\u56e0\u5c31\u662f\u5728\u76ee\u524d\u7684\u836f\u7269\u7814\u53d1\u4e2d\u4f9d\u7136\u9075\u5faa\u201c\u4e00\u4e2a\u836f\u7269\u3001\u4e00\u4e2a\u57fa\u56e0\u3001\u4e00\u79cd\u75be\u75c5\u201d\u7684\u6a21\u5f0f\u3002\u7136\u800c\u5927\u591a\u6570\u590d\u6742\u75be\u75c5\u90fd\u662f\u591a\u57fa\u56e0\u4f5c\u7528\u5bfc\u81f4\u7684\uff0c\u7f51\u7edc\u836f\u7406\u5b66\u8ba4\u4e3a\u5355\u4e00\u9776\u6807\u7684\u5e72\u9884\u8fdc\u8fdc\u4e0d\u8db3\u4ee5\u5bf9\u590d\u6742\u7cfb\u7edf\u6027\u75be\u75c5\u4ea7\u751f\u597d\u7684\u6548\u679c\uff0c\u56e0\u6b64\u836f\u7269\u7814\u53d1\u5e94\u8be5\u4ece\u5355\u4e00\u9776\u6807\u5411\u201c\u7f51\u7edc\u9776\u5411-\u591a\u7ec4\u5206\u6cbb\u7597\u201d\u7684\u6a21\u5f0f\u8f6c\u53d8[19]\uff0c\u751f\u7269\u7f51\u7edc\u7814\u7a76\u4e3a\u57fa\u4e8e\u591a\u9776\u6807\u7684\u836f\u7269\u7814\u53d1\u63d0\u4f9b\u4e86\u57fa\u7840\u3002<\/span><\/p>\n


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\u836f\u7269\u9776\u6807\u9884\u6d4b\u3002<\/span><\/strong>\u836f\u7269\u9776\u6807\u7684\u4f5c\u7528\u5173\u7cfb\u662f\u836f\u7269\u7814\u53d1\u548c\u8bbe\u8ba1\u7684\u57fa\u7840\uff0c\u4f46\u662f\u836f\u7269\u9776\u6807\u4f5c\u7528\u7684\u5b9e\u9a8c\u662f\u975e\u5e38\u8017\u8d39\u8d44\u6e90\u7684\u3002\u56e0\u6b64\uff0c\u57fa\u4e8e\u8ba1\u7b97\u8f85\u52a9\u7684\u836f\u7269\u9776\u6807\u9884\u6d4b\u65b9\u6cd5\u53ef\u4ee5\u53d1\u73b0\u836f\u7269\u7684\u6f5c\u5728\u9776\u70b9\uff0c\u4e3a\u5b9e\u9a8c\u9a8c\u8bc1\u53d1\u73b0\u65b0\u7684\u836f\u7269\u7597\u6548\u63d0\u4f9b\u7406\u8bba\u57fa\u7840\u3002<\/span><\/p>\n


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 <\/span><\/p>\n

<\/section>\n

\u5176\u4e2d\uff0c<d<\/span>AB<\/span>>\uff0c<d<\/span>AA<\/span>>\uff0c<d<\/span>BB<\/span>>\u548c\u5206\u522b\u8868\u793a\u6a21\u5757 AB \u4e4b\u95f4\uff0c\u6a21\u5757 A \u4ee5\u53ca\u6a21\u5757 B \u4e4b\u5185\u7684\u8282\u70b9\u5bf9\u7684\u5e73\u5747\u6700\u77ed\u8ddd\u79bb\u3002S<0 \u8868\u793a\u4e24\u4e2a\u6a21\u5757\u662f\u91cd\u53e0\u5173\u7cfb\uff0cS>0 \u8868\u793a\u4e24\u4e2a\u6a21\u5757\u662f\u5206\u79bb\u5173\u7cfb\u3002\u76f8\u5173\u7814\u7a76\u65b9\u6cd5\u4e5f\u5e94\u7528\u4e8e\u65b0\u51a0\u80ba\u708e\u75c5\u6bd2\u7684\u836f\u7269\u7ec4\u5408\u6cbb\u7597\u7814\u7a76\u4e2d[27]\u3002<\/span><\/p>\n

 <\/span><\/p>\n

<\/section>\n
\u56fe4\uff1a\u836f\u7269-\u836f\u7269-\u75be\u75c5\u5728\u7f51\u7edc\u4e2d\u7684\u5173\u7cfb\u56fe<\/span><\/strong><\/span>
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\u5c55\u671b\u4e0e\u6311\u6218<\/strong><\/span><\/p>\n

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\u8fd1\u5e74\u6765\uff0c\u8ba1\u7b97\u751f\u7269\u7f51\u7edc\u5728\u7406\u8bba\u548c\u65b9\u6cd5\u90fd\u53d6\u5f97\u4e86\u4e30\u7855\u7684\u6210\u679c\uff0c\u5e76\u5e7f\u6cdb\u5e94\u7528\u4e8e\u7406\u89e3\u751f\u7269\u5206\u5b50\u7684\u5185\u5728\u8054\u7cfb\u3001\u75be\u75c5\u7684\u53d1\u73b0\u53ca\u6cbb\u7597\u548c\u836f\u7269\u7684\u7814\u53d1\u7b49\u7b49\u3002\u8bba\u6587\u4e3b\u8981\u68b3\u7406\u4e86\u5982\u4e0b\u51e0\u4e2a\u65b9\u9762\u6311\u6218\u4e0e\u53d1\u5c55\u65b9\u5411\u3002\uff081\uff09\u76ee\u524d\u7684\u751f\u7269\u7f51\u7edc\u6570\u636e\u5b58\u5728\u7740\u4e0d\u5e73\u8861\u4e0d\u5b8c\u6574\u7684\u7f3a\u9677\uff0c\u9ad8\u8d28\u91cf\u7684\u751f\u7269\u7f51\u7edc\u6570\u636e\u83b7\u53d6\u65b9\u6cd5\uff0c\u4e5f\u662f\u751f\u7269\u7f51\u7edc\u7814\u7a76\u7684\u91cd\u8981\u57fa\u7840\u3002\uff082\uff09\u751f\u7269\u7f51\u7edc\u5305\u542b\u591a\u79cd\u751f\u7269\u5206\u5b50\u4e0d\u540c\u7c7b\u578b\u7684\u8fde\u63a5\uff0c\u4e3a\u5f02\u6784\u7f51\u7edc\u4ee5\u53ca\u7f51\u7edc\u7684\u7f51\u7edc\u7b49\u65b9\u9762\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u826f\u597d\u7684\u573a\u666f\u3002\uff083\uff09\u751f\u7269\u7f51\u7edc\u6570\u636e\u590d\u6742\u5ea6\u9ad8\uff0c\u57fa\u4e8e\u673a\u5668\u5b66\u4e60\u7279\u522b\u662f\u6df1\u5ea6\u5b66\u4e60\u7684\u7814\u7a76\u5e94\u7528\uff0c\u5c06\u4e3a\u591a\u7ef4\u5ea6\u7684\u751f\u7269\u7f51\u7edc\u6570\u636e\u5206\u6790\u5e26\u6765\u65b0\u7684\u673a\u9047\u3002\uff084\uff09\u57fa\u4e8e\u751f\u7269\u8bd5\u9a8c\u7684\u5047\u8bbe\u4e0e\u9a8c\u8bc1\u5bf9\u4e8e\u751f\u7269\u7f51\u7edc\u7814\u7a76\u4e5f\u5c24\u4e3a\u91cd\u8981\uff0c\u8fd9\u90fd\u9700\u8981\u4e0d\u540c\u5b66\u79d1\u7684\u7814\u7a76\u4eba\u5458\u4ece\u4e0d\u540c\u89d2\u5ea6\u4e3a\u8be5\u9886\u57df\u7684\u53d1\u5c55\u505a\u51fa\u8d21\u732e\u3002<\/span><\/p>\n


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\u53c2\u8003\u6587\u732e\uff1a<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n
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[1] M. Costanzo, et al., The genetic landscape of a cell, Science 327 (2010) 425\u2013431.<\/span><\/p>\n

[2] H. Jeong, S. Mason, A.-L. Barab\u00e1si, Z. Oltvai, Lethality and centrality in protein networks, Nature 411 (2001) 41-42<\/span><\/p>\n

[3] E. Ravasz, A. Somera, D. A. Mongru, Z. Oltvai, A.-L. Barab\u00e1si, Hierarchical organization of modularity in metabolic networks, Science 297 (2002) 1551\u20131555<\/span><\/p>\n

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\u5546\u52a1\u5408\u4f5c\u53ca\u6295\u7a3f\u8f6c\u8f7d\uff5cswarma@swarma.org
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\u5bfc\u8bed \u751f\u7269\u7f51\u7edc\u662f\u7f51\u7edc\u79d1\u5b66\u7684\u91cd\u8981\u7814\u7a76\u65b9\u5411\uff0c\u86cb\u767d\u8d28\u7f51\u7edc\u7b49\u7814\u7a76\u5df2\u7ecf\u5728\u65b0\u51a0\u80ba\u708e\u836f\u7269\u641c\u7d22\u4e2d\u53d1\u6325\u4e86\u4f5c\u7528\u3002\u8fd1\u65e5\u7531\u963f\u91cc\u5df4\u5df4\u590d\u6742\u79d1\u5b66\u7814\u7a76\u4e2d\u5fc3\u5f20\u5b50\u67ef\u3001\u7f8e\u56fd\u514b\u5229\u592b\u5170\u533b\u5b66\u4e2d\u5fc3\u7a0b\u98de\u96c4\u3001\u745e\u58eb\u5f17\u91cc\u5821\u5927\u5b66\u5f20\u7ffc\u6210\u7b49\u4eba\u7ec4\u6210\u7684\u7814\u7a76\u56e2\u961f\uff0c\u5728\u7269\u7406\u5b66\u9876\u520a Physics Reports \u53d1\u8868\u7efc\u8ff0\u6587\u7ae0\uff0c\u5168\u9762\u4ecb\u7ecd\u4e86\u5e38\u89c1\u751f\u7269\u7f51\u7edc\u7c7b\u578b\u3001\u7f51\u7edc\u7ed3\u6784\u3001\u5206\u6790…<\/p>\n","protected":false},"author":1,"featured_media":19638,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/19649"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19649"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/19649\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/19638"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19649"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19649"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19649"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=19649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}