{"id":20086,"date":"2020-06-17T20:49:06","date_gmt":"2020-06-17T12:49:06","guid":{"rendered":"https:\/\/swarma.org\/?p=20086"},"modified":"2020-06-17T20:49:06","modified_gmt":"2020-06-17T12:49:06","slug":"%e7%94%9f%e5%91%bd%e6%98%af%e6%80%8e%e6%a0%b7%e6%b6%8c%e7%8e%b0%e7%9a%84%ef%bc%9a%e7%b3%bb%e7%bb%9f%e7%94%9f%e7%89%a9%e5%ad%a6%e5%85%a5%e9%97%a8%e5%85%a8%e8%b7%af%e5%be%84","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=20086","title":{"rendered":"\u751f\u547d\u662f\u600e\u6837\u6d8c\u73b0\u7684\uff1a\u7cfb\u7edf\u751f\u7269\u5b66\u5165\u95e8\u5168\u8def\u5f84"},"content":{"rendered":"
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\u7cfb\u7edf\u751f\u7269\u5b66\uff08Systems biology\uff09\uff0c\u662f\u4e00\u4e2a\u4f7f\u7528\u6574\u4f53\u8bba\uff08\u800c\u975e\u8fd8\u539f\u8bba\uff09\u7814\u7a76\u8303\u5f0f\uff0c\u6574\u5408\u4e0d\u540c\u5b66\u79d1\u3001\u5c42\u6b21\u7684\u4fe1\u606f\u4ee5\u7406\u89e3\u751f\u7269\u7cfb\u7edf\u5982\u4f55\u884c\u4f7f\u529f\u80fd\u7684\u5b66\u672f\u9886\u57df\uff0c\u662f\u5206\u5b50\u751f\u7269\u5b66\u4e4b\u540e\u73b0\u4ee3\u751f\u7269\u5b66\u7684\u5168\u65b0\u9636\u6bb5\uff0c\u5305\u62ec\u8868\u89c2\u9057\u4f20\u5b66\u3001\u5404\u79cd\u751f\u7269\u7ec4\u5b66\u3001\u5408\u6210\u751f\u7269\u5b66\u3001\u751f\u7269\u4fe1\u606f\u5b66\u7b49\u7ec6\u5206\u9886\u57df\u3002<\/span><\/p>\n


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Can a biologist fix a radio?\u2014Or\uff0c what I learned while studying apoptosis<\/span><\/section>\n
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\u4e8b\u5b9e\u4e0a\uff0c\u636e 2011 \u5e74\u7684\u300acell\u300b\u62a5\u5bfc\uff0c\u8fd9\u4e00\u58ee\u4e3e\u5df2\u7ecf\u5728\u751f\u6b96\u652f\u539f\u4f53\uff08Mycoplasma genitalium\uff09\u7684\u7ec6\u80de\u6a21\u578b\u4e2d\u5b9e\u73b0\u4e86\uff0c\u5176\u4e2d\u6240\u6709\u7684\u57fa\u56e0\u3001\u4ea7\u7269\u4ee5\u53ca\u5df2\u77e5\u7684\u4ee3\u8c22\u76f8\u4e92\u4f5c\u7528\u90fd\u5df2\u5728\u7535\u8111\u4e2d\u91cd\u5efa[2]\u3002<\/span><\/section>\n

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A whole-cell computational model predicts phenotype from genotype<\/span><\/section>\n
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https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867412007763<\/section>\n<\/blockquote>\n

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1924-1928 \u5e74\u5965\u5730\u5229\u751f\u7269\u5b66\u5bb6\u8d1d\u5854\u90ce\u83f2\u591a\u6b21\u53d1\u8868\u7cfb\u7edf\u8bba\u7684\u6587\u7ae0\uff0c\u9610\u8ff0\u751f\u7269\u5b66\u4e2d\u6709\u673a\u4f53\u6982\u5ff5\uff0c\u63d0\u51fa\u628a\u6709\u673a\u4f53\u5f53\u4f5c\u4e00\u4e2a\u6574\u4f53\u6216\u7cfb\u7edf\u6765\u7814\u7a76\u3002\u8d1d\u5854\u6717\u83f2\u7684\u4e00\u822c\u7cfb\u7edf\u8bba<\/strong>\uff0c\u7ef4\u7eb3\u7684\u63a7\u5236\u8bba<\/strong>\u5230\u9999\u519c\u7684\u4fe1\u606f\u8bba<\/strong>\uff0c\u53ca\u666e\u5229\u9ad8\u6d25\u7684\u8017<\/strong>\u6563\u7ed3\u6784\u7406\u8bba\uff08Dissipative structures\uff09<\/strong>\uff0c\u5747\u5c06\u751f\u547d\u73b0\u8c61\u770b\u4f5c\u533a\u522b\u4e8e\u4ec5\u9760\u5916\u90e8\u6307\u4ee4\u8fd0\u4f5c\u7684\u81ea\u7ec4\u7ec7\u7cfb\u7edf\u3002<\/span><\/section>\n

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\u81ea 20 \u4e16\u7eaa 60 \u5e74\u4ee3\u7cfb\u7edf\u751f\u7269\u5b66\u6982\u5ff5\u548c\u8bcd\u6c47\u7684\u63d0\u51fa\u8d77\uff0c60-80 \u5e74\u4ee3\u7cfb\u7edf\u751f\u6001\u5b66\u3001\u7cfb\u7edf\u751f\u7406\u5b66\u7684\u8fdb\u5c55\uff0c90 \u5e74\u4ee3\u7cfb\u7edf\u751f\u7269\u533b\u5b66\u3001\u7cfb\u7edf\u533b\u5b66\u3001\u7cfb\u7edf\u751f\u7269\u5de5\u7a0b\u4e0e\u7cfb\u7edf\u9057\u4f20\u5b66\u7684\u6982\u5ff5\u53d1\u8868\uff0c\u4e0e 20 \u4e16\u7eaa\u672a\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u4e0e\u57fa\u56e0\u8c03\u63a7\u7684\u7814\u7a76\u4e0e\u7cfb\u7edf\u8bba\u65b9\u6cd5\u7684\u7ed3\u5408\u540e\uff0c\u7cfb\u7edf\u751f\u7269\u5b66\u8fdb\u5165\u4e86\u5206\u5b50\u7ec6\u80de\u5c42\u6b21\u7684\uff08\u5b9e\u9a8c\u4e0e\u7406\u8bba\u7ed3\u5408\uff09\u7814\u7a76\u4e0e\u53d1\u5c55\u65f6\u671f\u3002\u5c24\u5176\u5728 1979 \u5e74\uff0c\u82f1\u56fd\u751f\u7269\u5316\u5b66\u5bb6\u827e\u6839\u63d0\u51fa\u8d85\u5faa\u73af\u7406\u8bba\uff08Hypercycles\uff09<\/strong>\uff0c\u5bf9\u65e0\u673a\u5206\u5b50\u81ea\u7ec4\u7ec7\u6210\u751f\u7269\u5927\u5206\u5b50\u7684\u53ef\u80fd\u673a\u5236\u8fdb\u884c\u4e86\u89e3\u91ca\uff0c\u6253\u901a\u4e86\u751f\u547d\u7cfb\u7edf\u548c\u65e0\u673a\u7269\u4e4b\u95f4\u7684\u6865\u6881\u3002<\/span><\/section>\n
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21\u4e16\u7eaa\uff0c\u7cfb\u7edf\u751f\u7269\u5b66\u7684\u53d1\u5c55\u8fdb\u5165\u4e86\u7ec6\u80de\u4fe1\u53f7\u8f6c\u5bfc\u4e0e\u57fa\u56e0\u8868\u8fbe\u8c03\u63a7\u7684\u7ec6\u80de\u5206\u5b50\u7cfb\u7edf\u751f\u7269\u5b66\u65f6\u671f\uff0c\u56fd\u9645\uff0c\u56fd\u5185\u7684\u7cfb\u7edf\u4e0e\u5408\u6210\u751f\u7269\u5b66<\/strong>\uff0c\u7cfb\u7edf\u9057\u4f20\u5b66<\/strong>\u7b49\u7814\u7a76\u673a\u6784\u7eb7\u7eb7\u5efa\u7acb\uff0c\u8ba9\u751f\u7269\u5b66\u8fdb\u5165\u4e86\u7cfb\u7edf\u751f\u547d\u79d1\u5b66\u65f6\u4ee3\u30022001 \u5e74\u7684\u7b2c\u4e8c\u5c4a\u56fd\u9645\u7cfb\u7edf\u751f\u7269\u5b66\u4f1a\u63d0\u51fa\u5bf9\u751f\u7269\u4f53\u6574\u4e2a\u8fc7\u7a0b\u505a\u5168\u9762\u6027\u7684\u5b9a\u91cf\u7814\u7a76\uff0c\u5e76\u5e0c\u671b\u5229\u7528\u8ba1\u7b97\u673a\u8fd0\u7b97\u6765\u9884\u6d4b\u7ec6\u80de\uff0c\u5668\u5b98\u7cfb\u7edf\u751a\u81f3\u5b8c\u6574\u751f\u7269\u4f53\u7684\u8868\u73b0\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\uff08HGP\uff1aHuman Genome Project ; 1990\u20132003\uff09\u7684\u53d1\u8d77\u4eba\u4e4b\u4e00\uff0c\u7f8e\u56fd\u79d1\u5b66\u5bb6\u83b1\u8bfa\u4f0a\u00b7\u80e1\u5fb7 \uff08Leroy Hood\uff09 \u662f\u7ec4\u5b66 \uff08Omics\uff09 <\/strong>\u751f\u7269\u6280\u672f\u5f00\u521b\u8005\u4e4b\u4e00\u3002\u6b63\u662f\u5728\u57fa\u56e0\u7ec4\u5b66\uff08Genomics\uff09<\/span>\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\uff08Proteomics\uff09\u7b49\u65b0\u578b\u5927\u79d1\u5b66\u53d1\u5c55\u7684\u57fa\u7840\u4e0a\uff0c\u5b55\u80b2\u4e86\u7cfb\u7edf\u751f\u7269\u5b66\u79cd\u79cd\u9ad8\u901a\u91cf\u751f\u7269\u6280\u672f\u548c\u751f\u7269\u4fe1\u606f\u6280\u672f\u3002<\/span><\/section>\n

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\u7814\u7a76\u7684\u56db\u4e2a\u9636\u6bb5<\/strong><\/span><\/p>\n

<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/section>\n

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1. \u521d\u6b65\u6a21\u578b\uff1a<\/strong><\/span><\/p>\n

\u662f\u5bf9\u9009\u5b9a\u7684\u67d0\u4e00\u751f\u7269\u7cfb\u7edf\u7684\u6240\u6709\u7ec4\u5206\u8fdb\u884c\u4e86\u89e3\u548c\u786e\u5b9a\uff0c\u63cf\u7ed8\u51fa\u8be5\u7cfb\u7edf\u7684\u7ed3\u6784\uff0c\u5305\u62ec\u57fa\u56e0\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u548c\u4ee3\u8c22\u9014\u5f84\uff0c\u4ee5\u53ca\u7ec6\u80de\u5185\u548c\u7ec6\u80de\u95f4\u7684\u4f5c\u7528\u673a\u7406\uff0c\u4ee5\u6b64\u6784\u9020\u51fa\u4e00\u4e2a\u521d\u6b65\u7684\u7cfb\u7edf\u6a21\u578b\u3002<\/span><\/p>\n


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2. \u89c2\u6d4b\u5b9e\u9a8c\uff1a<\/strong><\/span><\/p>\n<\/h3>\n

\n

\u662f\u7cfb\u7edf\u5730\u6539\u53d8\u88ab\u7814\u7a76\u5bf9\u8c61\u7684\u5185\u90e8\u7ec4\u6210\u6210\u5206\uff08\u5982\u57fa\u56e0\u7a81\u53d8\uff09\u6216\u5916\u90e8\u751f\u957f\u6761\u4ef6\uff0c\u7136\u540e\u89c2\u6d4b\u5728\u8fd9\u4e9b\u60c5\u51b5\u4e0b\u7cfb\u7edf\u7ec4\u5206\u6216\u7ed3\u6784\u6240\u53d1\u751f\u7684\u76f8\u5e94\u53d8\u5316\uff0c\u5305\u62ec\u57fa\u56e0\u8868\u8fbe\u3001\u86cb\u767d\u8d28\u8868\u8fbe\u548c\u76f8\u4e92\u4f5c\u7528\u3001\u4ee3\u8c22\u9014\u5f84\u7b49\u7684\u53d8\u5316\uff0c\u5e76\u628a\u5f97\u5230\u7684\u6709\u5173\u4fe1\u606f\u8fdb\u884c\u6574\u5408\u3002<\/span><\/p>\n


<\/span><\/p>\n<\/h3>\n

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3. \u5206\u6790\u4fee\u8ba2\uff1a<\/strong><\/span><\/p>\n<\/h3>\n

\n

\u628a\u901a\u8fc7\u5b9e\u9a8c\u5f97\u5230\u7684\u6570\u636e\u4e0e\u6839\u636e\u6a21\u578b\u9884\u6d4b\u7684\u60c5\u51b5\u8fdb\u884c\u6bd4\u8f83\uff0c\u5e76\u5bf9\u521d\u59cb\u6a21\u578b\u8fdb\u884c\u4fee\u8ba2\u3002<\/span><\/p>\n


<\/span><\/p>\n<\/h3>\n

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4. \u7406\u60f3\u6a21\u578b\uff1a<\/strong><\/span><\/p>\n<\/h3>\n

\n
\u6839\u636e\u4fee\u6b63\u540e\u7684\u6a21\u578b\u7684\u9884\u6d4b\u6216\u5047\u8bbe\uff0c\u8bbe\u5b9a\u548c\u5b9e\u65bd\u65b0\u7684\u6539\u53d8\u7cfb\u7edf\u72b6\u6001\u7684\u5b9e\u9a8c\uff0c\u91cd\u590d\u7b2c\u4e8c\u6b65\u548c\u7b2c\u4e09\u6b65\uff0c\u4e0d\u65ad\u5730\u901a\u8fc7\u5b9e\u9a8c\u6570\u636e\u5bf9\u6a21\u578b\u8fdb\u884c\u4fee\u8ba2\u548c\u7cbe\u7ec3\u3002\u7b2c\u4e00\u5230\u7b2c\u4e09\u9636\u6bb5\uff0c\u4e5f\u5c31\u662f\u6240\u8c13\u7684\u201c\u6574\u5408\u201d- \u7cfb\u7edf\u7406\u8bba\u3001\u201c\u5e72\u6d89\u201d- \u5b9e\u9a8c\u751f\u7269\u5b66\u548c\u201c\u4fe1\u606f\u201d- \u8ba1\u7b97\u751f\u7269\u5b66\u7814\u7a76\u8fc7\u7a0b\uff0c\u5373\u7cfb\u7edf\u751f\u7269\u5b66\u901a\u8fc7\u7cfb\u7edf\u8bba\u548c\u5b9e\u9a8c\uff08Experimental\uff09\u3001\u8ba1\u7b97\uff08Computational\uff09\u7b49\u6982\u5ff5\u548c\u65b9\u6cd5\u7684\u6574\u5408\uff0c\u76ee\u6807\u5c31\u662f\u8981\u5f97\u5230\u4e00\u4e2a\u7406\u60f3\u7684\u5b8c\u6574\u6a21\u578b\uff0c\u4f7f\u5176\u7406\u8bba\u9884\u6d4b\u80fd\u591f\u5168\u9762\u53cd\u6620\u51fa\u751f\u7269\u7cfb\u7edf\u7684\u771f\u5b9e\u6027\u3002<\/span><\/section>\n<\/h3>\n

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\u56fe4\uff1a\u7cfb\u7edf\u751f\u7269\u5b66\u91cd\u6784\u4ee3\u8c22\u8fc7\u7a0b\u7684\u56db\u4e2a\u9636\u6bb5<\/span><\/strong><\/span><\/section>\n<\/h3>\n
 <\/span><\/section>\n
\u4ee5\u4e0a\u56fe\u56db\u4e2a\u9636\u6bb5\u4e3a\u4f8b\uff0c\u6bcf\u4e00\u4e2a\u9636\u6bb5\u90fd\u662f\u5728\u524d\u4e00\u4e2a\u9636\u6bb5\u7684\u57fa\u7840\u4e0a\u5efa\u7acb\u8d77\u6765\u7684\u3002\u91cd\u6784\u8fc7\u7a0b\u7684\u53e6\u4e00\u4e2a\u7279\u70b9\u662f\u91cd\u6784\u5185\u5bb9\u7684\u8fed\u4ee3\u7ec6\u5316\uff0c\u8fd9\u662f\u7531\u540e\u4e09\u4e2a\u9636\u6bb5\u7684\u5b9e\u9a8c\u6570\u636e\u9a71\u52a8\u7684\u3002\u5bf9\u4e8e\u6bcf\u4e2a\u9636\u6bb5\uff0c\u90fd\u9700\u8981\u7279\u5b9a\u7684\u6570\u636e\u7c7b\u578b\uff0c\u8fd9\u4e9b\u6570\u636e\u7c7b\u578b\u5305\u62ec\u4ece\u9ad8\u901a\u91cf\u6570\u636e\u7c7b\u578b\uff08\u4f8b\u5982\uff0c\u57fa\u56e0\u7ec4\u5b66\u548c\u4ee3\u8c22\u7ec4\u5b66\uff09\u5230\u63cf\u8ff0\u5355\u4e2a\u6210\u5206\u7684\u8be6\u7ec6\u7814\u7a76\uff08\u4f8b\u5982\uff0c\u7279\u5b9a\u53cd\u5e94\u7684\u751f\u5316\u6570\u636e\uff09\u3002\u6bcf\u4e2a\u91cd\u6784\u9636\u6bb5\u751f\u6210\u7684\u7ed3\u679c\u53ef\u4ee5\u7528\u4e8e\u68c0\u67e5\u8d8a\u6765\u8d8a\u591a\u7684\u95ee\u9898\uff0c\u6700\u7ec8\u83b7\u5f97\u7406\u60f3\u6a21\u578b[3]\u3002<\/span><\/section>\n

<\/span><\/section>\n
\n
\u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
Reconstruction of Biochemical Networks in Microorganisms<\/span><\/section>\n
\u8bba\u6587\u5730\u5740\uff1a<\/section>\n
https:\/\/www.nature.com\/articles\/nrmicro1949<\/section>\n<\/blockquote>\n
 <\/span><\/section>\n

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\u7814\u7a76\u65b9\u6cd5\u5206\u7c7b<\/strong><\/span><\/p>\n

<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/section>\n<\/h2>\n

\n
\u201c\u5e72\u6d89\u201d\u4e0e\u201c\u53d1\u73b0\u201d\u7684\u79d1\u5b66<\/span><\/strong><\/span><\/section>\n<\/h3>\n

<\/section>\n
1. \u5e72\u6d89<\/span><\/strong><\/section>\n
\u51e1\u662f\u5b9e\u9a8c\u79d1\u5b66\u90fd\u6709\u8fd9\u6837\u4e00\u79cd\u7279\u5f81\uff1a\u4eba\u4e3a\u5730\u8bbe\u5b9a\u67d0\u79cd\u6216\u67d0\u4e9b\u6761\u4ef6\u53bb\u4f5c\u7528\u4e8e\u88ab\u5b9e\u9a8c\u7684\u5bf9\u8c61\uff0c\u4ece\u800c\u8fbe\u5230\u5b9e\u9a8c\u7684\u76ee\u7684\u3002\u8fd9\u79cd\u5bf9\u5b9e\u9a8c\u5bf9\u8c61\u7684\u4eba\u4e3a\u5f71\u54cd\u5c31\u662f\u5e72\u6d89 \uff08Perturbation\uff09<\/strong>\u3002\u7cfb\u7edf\u751f\u7269\u5b66\u4e2d\u7684\u5e72\u6d89\u6709\u8fd9\u6837\u4e00\u4e9b\u7279\u70b9\u3002\u9996\u5148\uff0c\u8fd9\u4e9b\u5e72\u6d89\u5e94\u8be5\u662f\u6709\u7cfb\u7edf\u6027\u7684\u3002\u4f8b\u5982\u4eba\u4e3a\u8bf1\u5bfc\u57fa\u56e0\u7a81\u53d8\uff0c\u8fc7\u53bb\u5927\u591a\u662f\u968f\u673a\u7684\uff1b\u800c\u5728\u8fdb\u884c\u7cfb\u7edf\u751f\u7269\u5b66\u7814\u7a76\u65f6\uff0c\u5e94\u8be5\u91c7\u7528\u7684\u662f\u5b9a\u5411\u7684\u7a81\u53d8\u6280\u672f\u3002<\/span><\/section>\n
 <\/span><\/section>\n
2. \u53d1\u73b0<\/span><\/strong><\/section>\n
\u4ee5\u6d4b\u5b9a\u57fa\u56e0\u7ec4\u5168\u5e8f\u5217\u6216\u5168\u90e8\u86cb\u767d\u8d28\u7ec4\u6210\u7684\u57fa\u56e0\u7ec4\u7814\u7a76\u6216\u86cb\u767d\u8d28\u7ec4\u7814\u7a76\u7b49\u201c\u89c4\u6a21\u578b\u5927\u79d1\u5b66\u201d\uff0c\u5e76\u4e0d\u5c5e\u4e8e\u7ecf\u5178\u7684\u5b9e\u9a8c\u79d1\u5b66\u3002\u8fd9\u7c7b\u5de5\u4f5c\u4e2d\u5e76\u4e0d\u9700\u8981\u5e72\u6d89\uff0c\u5176\u76ee\u6807\u53ea\u662f\u628a\u7cfb\u7edf\u7684\u5168\u90e8\u5143\u7d20\u6d4b\u5b9a\u6e05\u695a\uff0c\u4ee5\u4fbf\u5f97\u5230\u4e00\u4e2a\u542b\u6709\u6240\u6709\u4fe1\u606f\u7684\u6570\u636e\u5e93\u3002\u83b1\u8bfa\u4f0a\u00b7\u80e1\u5fb7\u628a\u8fd9\u79cd\u7c7b\u578b\u7684\u7814\u7a76\u79f0\u4e3a\u201c\u53d1\u73b0\u7684\u79d1\u5b66\u201d \uff08Discovery Science\uff09<\/strong>\uff0c\u800c\u628a\u4e0a\u8ff0\u4f9d\u8d56\u4e8e\u5e72\u6d89\u7684\u5b9e\u9a8c\u79d1\u5b66\u79f0\u4e3a\u201c\u5047\u8bbe\u9a71\u52a8\u7684\u79d1\u5b66\u201d \uff08Hypothesis-driven science\uff09\uff0c\u56e0\u4e3a\u9009\u62e9\u5e72\u6d89\u5c31\u662f\u5728\u505a\u51fa\u5047\u8bbe\u3002<\/span><\/section>\n

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\u201c\u5e72\u201d\u4e0e\u201c\u6e7f\u201d\u5b9e\u9a8c<\/span><\/strong><\/span><\/section>\n<\/h3>\n

<\/span><\/section>\n
\u79bb\u5f00\u4e86\u6570\u5b66\u548c\u8ba1\u7b97\u673a\u79d1\u5b66\uff0c\u5c31\u4e0d\u4f1a\u6709\u7cfb\u7edf\u751f\u7269\u5b66\u3002\u4e5f\u8bb8\u6b63\u662f\u57fa\u4e8e\u8fd9\u4e00\u8003\u8651\uff0c\u79d1\u5b66\u5bb6\u628a\u7cfb\u7edf\u751f\u7269\u5b66\u5206\u4e3a\u201c\u6e7f\u201d\u7684\u5b9e\u9a8c\u90e8\u5206\uff08\u5b9e\u9a8c\u5ba4\u5185\u7684\u7814\u7a76\uff09\u548c\u201c\u5e72\u201d\u7684\u5b9e\u9a8c\u90e8\u5206\uff08\u8ba1\u7b97\u673a\u6a21\u62df\u548c\u7406\u8bba\u5206\u6790\uff09\u3002<\/span><\/section>\n

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<\/section>\n
\u56fe5\uff1a\u7cfb\u7edf\u751f\u7269\u5b66\u5305\u62ec\u201c\u5e72\u201d\u201c\u6e7f\u201d\u7ed3\u5408\u4ee5\u4e0d\u65ad\u4f18\u5316\u751f\u7269\u6a21\u578b\u7684\u7814\u7a76\u8fc7\u7a0b<\/span><\/strong><\/span><\/section>\n

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\u201c\u81ea\u9876\u5411\u4e0b\u201d\u4e0e\u201c\u81ea\u4e0b\u800c\u4e0a\u201d\u7684\u65b9\u6cd5<\/span><\/strong><\/span><\/section>\n

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\u7cfb\u7edf\u751f\u7269\u5b66\u7684\u76ee\u7684\u662f\u5728\u8ba1\u7b97\u673a\u6a21\u578b\uff08\u6216\u6570\u5b66\u6a21\u578b\uff09\u4e2d\u91cd\u5efa\u4e00\u4e2a\u751f\u7269\u7cfb\u7edf\uff0c\u7136\u540e\u7528\u6765\u6a21\u62df\u7cfb\u7edf\u7684\u884c\u4e3a\u3002\u57fa\u672c\u4e0a\u6709\u4e24\u79cd\u7cfb\u7edf\u751f\u7269\u5b66\u7684\u65b9\u6cd5\uff0c\u201c\u81ea\u9876\u5411\u4e0b\u201d\u4ece\u5168\u90e8\u7ec4\u5b66\u5206\u6790\u5f00\u59cb\uff0c\u800c\u201c\u81ea\u4e0b\u800c\u4e0a\u201d\u662f\u4ece\u5df2\u77e5\u7684\u5355\u4e2a\u8def\u5f84\u5f00\u59cb\uff0c\u5728\u5b9e\u9645\u5e94\u7528\u4e2d\u5b83\u4eec\u53ef\u4ee5\u4e92\u8865\u800c\u4e0d\u662f\u76f8\u4e92\u6392\u65a5[4]\u3002<\/span><\/section>\n
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\u56fe6\uff1a\u663e\u793a\u4e0d\u540c\u7684\u7cfb\u7edf\u751f\u7269\u5b66\u624b\u6bb5\uff1a\u5728\u81ea\u9876\u5411\u4e0b\u7684\u7cfb\u7edf\u751f\u7269\u5b66\u4e2d\uff0c\u9ad8\u901a\u91cf\u7684\u5b9e\u9a8c\u6570\u636e\uff0c\u8fd9\u4e9b\u6570\u636e\u88ab\u7528\u6765\u91cd\u5efa\u901a\u8def\u6216\u5171\u8c03\u63a7\u6a21\u5757\u3002\u8fd9\u4e9b\u6a21\u5757\u53ef\u4ee5\u6210\u4e3a\u66f4\u8be6\u7ec6\u7684\u7814\u7a76\u7684\u57fa\u7840\uff0c\u5176\u4e2d\u5355\u4e2a\u7ec4\u4ef6\u7684\u52a8\u529b\u5b66\u88ab\u91cf\u5316\u3002\u5728\u81ea\u4e0b\u800c\u4e0a\u7684\u7cfb\u7edf\u751f\u7269\u5b66\u4e2d\uff0c\u901a\u8def\u7684\u91cd\u5efa\u662f\u57fa\u4e8e\u5bf9\u4e2a\u4f53\u6210\u5206\u76f8\u4e92\u4f5c\u7528\u7684\u7814\u7a76\u3002<\/span><\/strong><\/span><\/section>\n
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1. \u81ea\u9876\u5411\u4e0b<\/span><\/strong><\/section>\n
\u81ea\u9876\u5411\u4e0b\u7684\u7cfb\u7edf\u751f\u7269\u5b66\uff08Top-down systems biology\uff09\u4f9d\u8d56\u4e8e\u4e0d\u540c\u7684\u5168\u57fa\u56e0\u7ec4\u5206\u6790<\/strong>\uff0c\u5728\u8fd9\u79cd\u5206\u6790\u4e2d\uff0c\u6570\u636e\u662f\u4ece\u4e00\u4e2a\u66b4\u9732\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u6216\u53d7\u5230\u57fa\u56e0\u5e72\u6270\uff08\u5982\u901a\u8fc7\u6572\u9664\u7279\u5b9a\u57fa\u56e0\uff09\u7684\u7cfb\u7edf\u4e2d\u6536\u96c6\u7684\u3002\u9996\u5148\uff0c\u57fa\u56e0\u3001\u86cb\u767d\u8d28\u548c\u4ee3\u8c22\u4ea7\u7269\u8868\u73b0\u51fa\u663e\u8457\u53d8\u5316\u8bc6\u522b\u4f7f\u7528\u9002\u5f53\u7684\u7edf\u8ba1\u65b9\u6cd5\uff08\u901a\u5e38\u4e0e\u591a\u4e2a\u6821\u6b63\u6d4b\u8bd5\uff09\uff0c\u7d27\u968f\u5176\u540e\u7684\u662f\u96c6\u7fa4\u548c\u66f4\u9ad8\u7ea7\u7684\u5206\u6790\uff0c\u5f97\u5230\u7684\u6570\u636e\u53ef\u4ee5\u7ed3\u5408\u7ed3\u6784\u4fe1\u606f\uff0c\u4f8b\u5982 DNA \u7684\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u6570\u636e\uff08\u4eceCHIP-chip\u5b9e\u9a8c\uff09\u3002\u8fd9\u79cd\u7c7b\u578b\u7684\u5206\u6790\u901a\u5e38\u4f7f\u8bc6\u522b\u534f\u540c\u8c03\u8282\u6a21\u5757\u6210\u4e3a\u53ef\u80fd\u3002\u81ea\u9876\u5411\u4e0b\u7684\u7cfb\u7edf\u751f\u7269\u5b66\u7684\u4f18\u70b9\u662f\u5b83\u662f\u975e\u6559\u6761\u7684\uff0c\u5e76\u4e14\u4e0d\u9700\u8981\u901a\u8def\u7ed3\u6784\u7684\u5148\u9a8c\u77e5\u8bc6\u3002<\/strong>\u7531\u4e8e\u5047\u9633\u6027\u7684\u53ef\u80fd\u6027\uff0c\u91cd\u6784\u7684\u901a\u8def\u9700\u8981\u7528\u4f20\u7edf\u7684\u5206\u5b50\u751f\u7269\u5b66\u8fdb\u884c\u5b9e\u9a8c\u9a8c\u8bc1\u3002<\/span><\/section>\n
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2. \u81ea\u4e0b\u800c\u4e0a<\/span><\/strong><\/section>\n
\u81ea\u4e0b\u800c\u4e0a\u7684\u7cfb\u7edf\u751f\u7269\u5b66\uff08Bottom-up systems biology\uff09\u4f9d\u8d56\u4e8e\u5df2\u77e5\u8def\u5f84\u6216\u5b50\u7cfb\u7edf\u7684\u53ef\u7528\u77e5\u8bc6\u3002<\/strong>\u8fd9\u79cd\u77e5\u8bc6\u88ab\u7ec4\u5408\u6210\u4e00\u4e2a\u6240\u8c13\u7684\u63cf\u8ff0\u6027\u6a21\u578b\u7684\uff0c\u5e76\u8f6c\u6362\u6210\u6570\u5b66\u6a21\u578b\u3002\u8be5\u6570\u5b66\u6a21\u578b\u53ef\u7528\u4e8e\u6a21\u62df\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684\u8def\u5f84\u8fd0\u884c\u3002\u901a\u8fc7\u4e0e\u5b9e\u9a8c\u6570\u636e\u7684\u6bd4\u8f83\uff0c\u6709\u53ef\u80fd\u4f30\u8ba1\u7cfb\u7edf\u6216\u8def\u5f84\u5185\u7684\u4e2a\u522b\u8fc7\u7a0b\u7684\u8be6\u7ec6\u52a8\u529b\u5b66\u3002\u5728\u5f97\u5230\u7cfb\u7edf\u7684\u53ef\u63a5\u53d7\u7684\u6570\u5b66\u8868\u793a\u4e4b\u524d\uff0c\u5e38\u5e38\u9700\u8981\u5bf9\u6a21\u578b\u8fdb\u884c\u4fee\u6b63\uff1b\u56e0\u6b64\uff0c\u9700\u8981\u4e0e\u5b9e\u9a8c\u5de5\u4f5c\u5bc6\u5207\u914d\u5408\uff0c\u8fdb\u884c\u6a21\u578b\u6784\u5efa\u548c\u4eff\u771f\u3002\u6240\u5f97\u6a21\u578b\u53ef\u7528\u4e8e\u8bbe\u8ba1\u5b9e\u9a8c\uff0c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u6216\u8bc1\u4f2a\u6a21\u578b\u3002\u8fd9\u4e2a\u8fc7\u7a0b\u7684\u6700\u7ec8\u7ed3\u679c\u662f\u4e00\u4e2a\u52a8\u6001\u6570\u5b66\u6a21\u578b\uff0c\u53ef\u4ee5\u7528\u6765\u6a21\u62df\u6240\u7814\u7a76\u7684\u751f\u7269\u7cfb\u7edf\u3002\u8fd9\u79cd\u65b9\u6cd5\u7684\u7f3a\u70b9\u662f\uff0c\u91cd\u5efa\u7684\u6a21\u578b\u9ad8\u5ea6\u4f9d\u8d56\u4e8e\u5f53\u524d\u5df2\u77e5\u7cfb\u7edf\u901a\u8def\u7684\u77e5\u8bc6\uff0c\u5c1a\u672a\u88ab\u8bc6\u522b\u6210\u5206\u7684\u5f71\u54cd\u5f80\u5f80\u4e00\u5f00\u59cb\u5b8c\u5168\u88ab\u5ffd\u7565\u6389\u3002<\/span><\/section>\n
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\u6559\u6750\u63a8\u8350<\/strong><\/span><\/p>\n

<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h2>\n

 <\/span><\/section>\n
\u4ee5\u4e0b\u63a8\u8350\u51e0\u672c\u6559\u6750\u9762\u5411\u7684\u53d7\u4f17\u662f\u4e0d\u540c\u7684\uff0c\u7b2c\u4e00\u672c\u9002\u5408\u5165\u95e8\uff0c\u7b2c\u4e8c\u672c\u548c\u7b2c\u4e09\u672c\u5219\u504f\u91cd\u54f2\u5b66\u5c42\u9762\uff0c\u7b2c\u56db\u672c\u548c\u7b2c\u4e94\u672c\u5219\u66f4\u52a0\u504f\u5411\u6280\u672f\u6027\u3002\u82f1\u6587\u6559\u6750\u53ea\u6709\u7b2c\u4e94\u672c\u6709\u4e2d\u8bd1\u7248\u3002\u90e8\u5206\u82f1\u6587\u4e66\u7c4d\u4ecb\u7ecd\u91cc\u9644\u6709\u94fe\u63a5\u3002<\/span><\/section>\n
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    \n
  • \n
    \u300a\u7cfb\u7edf\u751f\u7269\u5b66\u300b<\/span><\/section>\n<\/li>\n
  • \n
    \u300aSystems Biology: Philosophical Foundations\u300b<\/span><\/section>\n<\/li>\n
  • \n
    \u300aLife: An Introduction to Complex Systems Biology\u300b<\/span><\/section>\n<\/li>\n
  • \n
    \u300aSystems Biology: Properties of Reconstructed Networks \u300b<\/span><\/section>\n<\/li>\n
  • \n
    \u300aAn Introduction to Systems Biology: Design Principles of Biological Circuits\u300b<\/span><\/section>\n<\/li>\n<\/ul>\n
     <\/span><\/section>\n
    1. \u5f20\u81ea\u7acb\u7f16\u8457\u7684\u300a\u7cfb\u7edf\u751f\u7269\u5b66\u300b\u662f\u76ee\u524d\u6211\u56fd\u9ad8\u6821\u4f7f\u7528\u7684\u6559\u6750<\/strong>\u3002\u6574\u5408\u4e86\u5404\u5c42\u9762\u7684\u751f\u7269\u4fe1\u606f\u6570\u636e\uff0c\u5efa\u7acb\u5404\u79cd\u6570\u5b66\u6a21\u578b\u8fdb\u884c\u4eff\u771f\u5b9e\u9a8c\uff0c\u8fdb\u800c\u5b9a\u91cf\u9610\u660e\u548c\u9884\u6d4b\u751f\u7269\u529f\u80fd\u3001\u8868\u578b\u53ca\u884c\u4e3a\u3002\u6982\u8ff0\u4e86\u7cfb\u7edf\u751f\u7269\u5b66\u7684\u57fa\u672c\u6982\u5ff5\u548c\u57fa\u672c\u5185\u5bb9\uff0c\u4ecb\u7ecd\u4e86\u57fa\u56e0\u7ec4\u5b66\uff08Genomics\uff09\u3001\u8f6c\u5f55\u7ec4\u5b66\uff08Transcriptome\uff09\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\uff08Proteomics<\/span>\uff09\u3001\u7cd6\u7ec4\u5b66\uff08Metabolomics<\/span>\uff09\u3001\u4ee3\u8c22\u7269\u7ec4\u5b66\uff08Metabolomics\uff09\u3001\u76f8\u4e92\u4f5c\u7528\u7ec4\u5b66\u3001\u8868\u578b\u7ec4\u5b66\u3001\u6570\u5b66\u5efa\u6a21\u4e0e\u4eff\u771f\u3001\u5e8f\u5217\u6bd4\u5bf9\u4e0e\u6570\u636e\u5e93\u641c\u7d22\u3001\u5206\u5b50\u8fdb\u5316\u6a21\u578b\u4e0e\u7cfb\u7edf\u6811\u7684\u6784\u5efa\u7b49\u3002<\/span><\/section>\n
     <\/span><\/section>\n
    2.\u300aSystems Biology: Philosophical Foundations\u300b\u662f\u7b2c\u4e00\u672c\u5173\u4e8e\u7cfb\u7edf\u751f\u7269\u5b66\u54f2\u5b66\u57fa\u7840<\/strong>\u7684\u4e66\u3002\u4ee3\u8868\u4e86\u8fd1\u5e74\u6765\u5728\u4e0e\u7cfb\u7edf\u751f\u7269\u5b66\u76f8\u5173\u7684\u4e00\u7cfb\u5217\u54f2\u5b66\u95ee\u9898\u4e0a\u7684\u7814\u7a76\u6210\u679c\u3002\u5305\u542b\u5341\u56db\u7bc7\u8bba\u6587\uff0c\u5206\u4e3a\u4e09\u4e2a\u90e8\u5206\u3002\u7b2c\u4e00\u90e8\u5206\u63cf\u8ff0\u4e86\u7cfb\u7edf\u751f\u7269\u5b66\u7814\u7a76\u8ba1\u5212\uff08\u7b2c2\u7ae0\u548c\u7b2c5\u7ae0\uff09\uff0c\u7b2c\u4e8c\u90e8\u5206\u8ba8\u8bba\u4e86\u7406\u8bba\u548c\u6a21\u578b\uff08\u7b2c6\u7ae0\u548c\u7b2c9\u7ae0\uff09\uff0c\u7b2c\u4e09\u90e8\u5206\u8ba8\u8bba\u4e86\u751f\u7269\u7cfb\u7edf\u4e2d\u7684\u7ec4\u7ec7\uff08\u7b2c10\u7ae0\u548c\u7b2c13\u7ae0\uff09\u3002<\/span><\/section>\n

    <\/section>\n
    \u5168\u6587\u4e0b\u8f7d\u94fe\u63a5\uff1a<\/span><\/section>\n
    https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780444520852500036?via%3Dihub#cesec1<\/span><\/section>\n

    <\/span><\/section>\n
    <\/section>\n

    <\/section>\n

    \u56fe7\uff1a\u300a<\/span><\/strong><\/span>Systems Biology: Philosophical Foundations<\/span><\/strong><\/span>\u300b\u5c01\u9762<\/span><\/strong><\/span><\/p>\n


    <\/span><\/section>\n
    3.\u300aLife: An Introduction to Complex Systems Biology\u300b\u8fd9\u672c 2003 \u5e74\u7531 kaneko \u5199\u4f5c\u7684\u4e66\uff0c2006 \u5e74\u518d\u7248\uff0c\u672c\u4e66\u4e00\u5171\u6709\u5341\u4e8c\u4e2a\u7ae0\u8282\uff0c\u4e3b\u8981\u662f\u9762\u5411\u5e74\u8f7b\u7684\u751f\u7269\u5b66\u5bb6\u548c\u7406\u8bba\u7269\u7406\u5b66\u5bb6\u3002<\/strong>\u8fd9\u672c\u63d0\u51fa\u7684\u95ee\u9898\uff1a\u4ec0\u4e48\u662f\u751f\u547d\u7cfb\u7edf\u7684\u901a\u7528\u5c5e\u6027\u548c\u4e00\u4e2a\u4eba\u600e\u4e48\u4ece\u751f\u547d\u7684\u7684\u73b0\u8c61\u5b66\u7406\u8bba<\/strong>\u6784\u9020\u5bfc\u81f4\u81ea\u7136\u751f\u6b96\u7ec6\u80de\u7b49\u590d\u6742\u8fc7\u7a0b\u7cfb\u7edf\u3001\u8fdb\u5316\u548c\u5206\u5316?<\/span><\/section>\n
     <\/span><\/section>\n
    \n

    \u7b2c\u4e00\u7ae0\uff0c\u56de\u987e\u4e86\u5206\u5b50\u751f\u7269\u5b66\u7684\u7814\u7a76\u73b0\u72b6\u3002\u5bf9\u73b0\u72b6\u63d0\u51fa\u6279\u8bc4\uff0c\u4ee5\u53ca\u9700\u8981\u7684\u662f\u53e6\u4e00\u79cd\u65b9\u6cd5\uff0c\u4f5c\u8005\u79f0\u4e4b\u4e3a\u590d\u6742\u7cfb\u7edf\u751f\u7269\u5b66\u3002\u5728\u7b2c2\u7ae0\u4e2d\uff0c\u4f5c\u8005\u6982\u8ff0\u4e86\u5efa\u6784\u751f\u7269\u5b66\u7684\u65b9\u6cd5\uff0c\u5373\u901a\u8fc7\u5b9e\u9a8c\uff08\u5728\u5b9e\u9a8c\u5ba4\u4e2d\uff09\u548c\u7406\u8bba\uff08\u5728\u8ba1\u7b97\u673a\u6a21\u578b\u4e2d\uff09\u6784\u5efa\u751f\u547d\u7684\u57fa\u672c\u7279\u5f81\u6765\u7406\u89e3\u5b83\u4eec\u3002\u5728\u7b2c3\u7ae0\u4e2d\uff0c\u4e00\u4e9b\u52a8\u529b\u5b66\u7cfb\u7edf\u548c\u7edf\u8ba1\u7269\u7406\u7684\u57fa\u672c\u80cc\u666f\u88ab\u63cf\u8ff0\uff0c\u4f5c\u4e3a\u5728\u540e\u9762\u7ae0\u8282\u63cf\u8ff0\u7684\u7814\u7a76\u7684\u57fa\u7840\u3002\u7b2c4\u7ae0\u81f3\u7b2c11\u7ae0\u4e2d\u8ba8\u8bba\u751f\u547d\u7cfb\u7edf\u7684\u57fa\u672c\u95ee\u9898\u3002\u8fd9\u4e9b\u95ee\u9898\u5305\u62ec\u9057\u4f20\uff08\u7b2c4\u7ae0\uff09\u3001\u7e41\u6b96\u548c\u65b0\u9648\u4ee3\u8c22\uff08\u7b2c5\u7ae0\u548c\u7b2c6\u7ae0\uff09\u3001\u7ec6\u80de\u5206\u5316\u3001\u53d1\u80b2\u548c\u5f62\u6001\u53d1\u751f\uff08\u7b2c7\u7ae0\u548c\u7b2c9\u7ae0\uff09\u3001\u4e0e\u751f\u7269\u53ef\u5851\u6027\u6709\u5173\u7684\u8fdb\u5316\uff08\u7b2c10\u7ae0\uff09\u548c\u591a\u6837\u5316\u7684\u7269\u79cd\u5f62\u6210\uff08\u7b2c11\u7ae0\uff09\u3002\u5728\u7b2c12\u7ae0\u4e2d\uff0c\u603b\u7ed3\u4e86\u4e66\u4e2d\u63d0\u51fa\u7684\u57fa\u672c\u6982\u5ff5\uff0c\u5982\u7a33\u5b9a\u589e\u957f\u7cfb\u7edf\u4e2d\u7684\u666e\u904d\u7edf\u8ba1\u3001\u76f8\u5e94\u7684\u591a\u6837\u5316\u3001\u5408\u5e76\u3001\u6d41\u52a8\u548c\u5c11\u6570\u63a7\u5236\u539f\u5219\u3002\u7136\u540e\u8ba8\u8bba\u5982\u4f55\u7406\u89e3\u751f\u7269\u7684\u53ef\u5851\u6027\u3001\u9012\u5f52\u6027\u548c\u8fdb\u5316\u6027\uff0c\u540c\u65f6\u5f3a\u8c03\u73b0\u8c61\u5b66\u7406\u8bba\u5728\u751f\u7269\u5b66\u7cfb\u7edf\u5c42\u9762\u7684\u5fc5\u8981\u6027\u548c\u53ef\u80fd\u6027\u3002<\/span><\/p>\n<\/section>\n


    <\/span><\/section>\n
    \u5168\u6587\u4e0b\u8f7d\u94fe\u63a5 \uff1a
    <\/span><\/section>\n
    https:\/\/link.springer.com\/book\/10.1007\/978-3-540-32667-0<\/span><\/section>\n

    <\/span><\/section>\n
    <\/section>\n
    \u56fe8\uff1aKaneko\u300aLife\uff1aAn Introduction to Complex Systems Biology\u300b\u5c01\u9762<\/span><\/strong><\/span><\/section>\n
     <\/span><\/section>\n
    \n

    4. Palsson\u7684\u300aSystems Biology: Properties of Reconstructed Networks \u300b\u662f\u66f4\u591a\u4ece\u6280\u672f\u5c42\u9762\u51fa\u53d1<\/strong>\uff0c\u4ee5\u6570\u5b66\u7684\u65b9\u5f0f\u8868\u793a\u5316\u5b66\u8ba1\u91cf\u77e9\u9635\uff0c\u800c\u8fd9\u4e2a\u77e9\u9635\u7684\u6027\u8d28\u662f\u51b3\u5b9a\u5b83\u6240\u4ee3\u8868\u7684\u751f\u5316\u53cd\u5e94\u7f51\u7edc\u7684\u5b98\u80fd\u72b6\u6001\u7684\u5173\u952e\u3002\u8fd9\u672c\u6559\u79d1\u4e66\uff0c\u81f4\u529b\u4e8e\u63cf\u8ff0\u5982\u4f55\u5efa\u6a21\u7f51\u7edc\uff0c\u5982\u4f55\u786e\u5b9a\u4ed6\u4eec\u7684\u6027\u8d28\uff0c\u4ee5\u53ca\u5982\u4f55\u5c06\u8fd9\u4e9b\u4e0e\u8868\u578b\u529f\u80fd\u91cd\u5efa\u4e3a\u8be6\u7ec6\u7684\uff0c\u548c\u53ef\u9884\u6d4b\u7535\u8def\u6a21\u578b\u7684\u751f\u7269\u7cfb\u7edf\u3002\u4e00\u4e9b\u7ebf\u6027\u4ee3\u6570\u548c\u751f\u7269\u5316\u5b66\u7684\u77e5\u8bc6\u5728\u9605\u8bfb\u4e4b\u524d\u5fc5\u4e0d\u53ef\u5c11\u3002<\/span><\/p>\n<\/section>\n


    <\/section>\n
    5.\u300aAn Introduction to Systems Biology\uff1aDesign Principles of Biological Circuits\u300b\u9996\u6b21\u5bf9\u7cfb\u7edf\u751f\u7269\u5b66\u7814\u7a76\u5de5\u4f5c\u7684\u6838\u5fc3\u548c\u7ec6\u8282\u8fdb\u884c\u6df1\u5165\u9610\u8ff0\uff0c\u4e3a\u76f4\u89c2\u7406\u89e3\u751f\u7269\u5b66\u4e2d\u4e00\u822c\u539f\u7406\u5efa\u7acb\u4e86\u57fa\u7840\u3002Alon \u7684\u4e66\u9002\u5408\u5047\u5b9a\u6ca1\u6709\u751f\u7269\u5b66\u7684\u77e5\u8bc6\uff0c\u751a\u81f3\u5bf9\u751f\u7269\u5b66\u4e0d\u611f\u5174\u8da3\u7684\u7269\u7406\u5b66\u5bb6<\/strong>\u3002\u5168\u4e66\u5185\u5bb9\u7f16\u6392\uff1a\u5bf9\u7f51\u7edc\u6a21\u4f53\u7b49\u65b0\u7684\u7406\u8bba\u7814\u7a76\u6210\u679c\u505a\u4e86\u7ec6\u81f4\u6df1\u5165\u7684\u9610\u8ff0\uff0c\u6307\u51fa\u4e86\u7cfb\u7edf\u751f\u7269\u5b66\u7684\u6838\u5fc3\u5185\u5bb9\u548c\u5b9e\u8df5\u65b9\u6cd5\uff1b\u9610\u660e\u4e86\u8f6c\u5f55\u8c03\u63a7\u3001\u4fe1\u53f7\u8f6c\u5bfc\u3001\u53d1\u80b2\u7f51\u7edc\u4e2d\u7684\u57fa\u672c\u56de\u8def\uff1b\u68c0\u6d4b\u4e86\u9c81\u68d2\u6027\u539f\u7406\uff1b\u6e05\u6670\u5730\u8bf4\u660e\u4e86\u5982\u4f55\u7528\u8fdb\u5316\u4f18\u5316\u6765\u7406\u89e3\u6700\u4f18\u56de\u8def\u8bbe\u8ba1\uff1b\u4ed4\u7ec6\u8003\u8651\u4e86\u52a8\u529b\u5b66\u6821\u6b63\u548c\u5176\u4ed6\u673a\u5236\u662f\u5982\u4f55\u4f7f\u751f\u7269\u4fe1\u606f\u5904\u7406\u4e2d\u7684\u8bef\u5dee\u51cf\u5230\u6700\u5c11\u3002<\/span><\/section>\n
     <\/span><\/section>\n

    <\/span><\/section>\n

    \n
    \n
    \n
    \n
    \n
    <\/p>\n

    \u7cfb\u7edf\u751f\u7269\u5b66\u7ecf\u5178\u6587\u732e<\/strong><\/span><\/p>\n

    <\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h2>\n

     <\/span><\/section>\n

    \n
    \u8d1d\u5854\u6717\u83f2\uff1a\u4e00\u822c\u7cfb\u7edf\u8bba<\/span><\/strong><\/span><\/section>\n<\/h3>\n

    <\/span><\/section>\n
    \u8def\u5fb7\u7ef4\u5e0c\u00b7\u51af\u00b7\u8d1d\u5854\u6717\u83f2\uff08Ludwig Von Bertalanffy\uff0c1901-1972\uff09\u2014\u7f8e\u7c4d\u5965\u5730\u5229\u7406\u8bba\u751f\u7269\u5b66\u5bb6\u548c\u54f2\u5b66\u5bb6\uff1b\u4e00\u822c\u7cfb\u7edf\u8bba\u7684\u521b\u59cb\u4eba\uff0c\u4ed6\u4ece\u751f\u7269\u5b66\u9886\u57df\u51fa\u53d1\uff0c\u6d89\u730e\u533b\u5b66\u3001\u5fc3\u7406\u5b66\u3001\u884c\u4e3a\u79d1\u5b66\u3001\u5386\u53f2\u5b66\u3001\u54f2\u5b66\u7b49\u8bf8\u591a\u5b66\u79d1\uff0c\u4ee5\u5176\u6e0a\u535a\u7684\u77e5\u8bc6\u3001\u6d53\u539a\u7684\u4eba\u6587\u79d1\u5b66\u4fee\u517b\uff0c\u521b\u7acb\u4e86\u672c\u4e16\u7eaa\u5177\u6709\u6df1\u8fdc\u610f\u4e49\u7684\u4e00\u822c\u7cfb\u7edf\u8bba\uff0c\u4f7f\u4ed6\u7684\u540d\u5b57\u6c38\u4e45\u5730\u4e0e\u7cfb\u7edf\u7406\u8bba\u8054\u7cfb\u5728\u4e00\u8d77\u30021972\u5e74\uff0c\u6cd5\u56fd\u79d1\u5b66\u5bb6\u59d4\u5458\u4f1a\u66fe\u63d0\u540d\u4ed6\u4e3a\u8bfa\u8d1d\u5c14\u5956\u5019\u9009\u4eba\uff0c\u4f46\u662f\u5728\u8bfa\u8d1d\u5c14\u5956\u8bc4\u9009\u59d4\u5458\u4f1a\u8ba8\u8bba\u63d0\u540d\u4e4b\u524d\uff0c\u8d1d\u5854\u6717\u83f2\u4e0d\u5e78\u8f9e\u4e16\u3002<\/span><\/section>\n

    <\/span><\/section>\n
    1950\u5e74\u53d1\u8868\u300a\u7269\u7406\u5b66\u4e0e\u751f\u7269\u5b66\u4e2d\u7684\u5f00\u653e\u7cfb\u7edf\u7406\u8bba\u300b\u521b\u7acb\u4e00\u822c\u7cfb\u7edf\u8bba\u5e76\u5960\u5b9a\u4e86\u7cfb\u7edf\u751f\u7269\u5b66\u7684\u57fa\u7840[5] [6]\u3002\u6211\u4eec\u53ef\u4ee5\u770b\u5230\uff0c\u7cfb\u7edf\u79d1\u5b66\u7684\u7814\u7a76\u548c\u521b\u7acb\u4e00\u5f00\u59cb\u5c31\u662f\u548c\u751f\u7269\u5b66\u606f\u606f\u76f8\u5173\u7684\u3002<\/span><\/section>\n
     <\/span><\/section>\n
    \n
    \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
    The Theory of Open Systems in Physics and Biology<\/span><\/section>\n
    \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
    https:\/\/science.sciencemag.org\/content\/111\/2872\/23\/tab-pdf <\/section>\n<\/blockquote>\n
    \n
    \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
    An Outline of General System Theory \uff081950\uff09<\/span><\/section>\n
    \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
    http:\/\/www.isnature.org\/Events\/2009\/Summer\/r\/Bertalanffy1950-GST_Outline_SELECT.pdf<\/section>\n<\/blockquote>\n
     <\/span><\/section>\n

    <\/span><\/section>\n

    \n
    \u666e\u5229\u9ad8\u6d25: \u7ed3\u6784\u8017\u6563\u7406\u8bba<\/span><\/strong><\/span><\/section>\n<\/h3>\n
     <\/span><\/section>\n
    \u666e\u5229\u9ad8\u6d25\uff08Ilya Prigogine\uff0c 1917-2003\uff09\u8ba4\u4e3a\uff0c\u53ea\u6709\u5728\u975e\u5e73\u8861\u7cfb\u7edf\u4e2d\uff0c\u5728\u4e0e\u5916\u754c\u6709\u7740\u7269\u8d28\u4e0e\u80fd\u91cf\u7684\u4ea4\u6362\u7684\u60c5\u51b5\u4e0b\uff0c\u7cfb\u7edf\u5185\u5404\u8981\u7d20\u5b58\u5728\u590d\u6742\u7684\u975e\u7ebf\u6027\u76f8\u5e72\u6548\u5e94\u65f6\u624d\u53ef\u80fd\u4ea7\u751f\u81ea\u7ec4\u7ec7\u73b0\u8c61\uff0c\u5e76\u4e14\u628a\u8fd9\u79cd\u6761\u4ef6\u4e0b\u751f\u6210\u7684\u81ea\u7ec4\u7ec7\u6709\u5e8f\u6001\u79f0\u4e4b\u4e3a\u8017\u6563\u7ed3\u6784\u3002\u4e00\u4e2a\u5bf9\u8c61\u8981\u60f3\u5728\u6d3b\u52a8\u4e2d\u83b7\u5f97\u5b58\u5728\u4e0e\u53d1\u5c55\uff0c\u5fc5\u987b\u4e0d\u65ad\u5730\u4ece\u5916\u754c\u5f15\u5165\u8d1f\u71b5\uff0c\u4ee5\u62b5\u6d88\u7cfb\u7edf\u4f53\u5185\u6b63\u71b5\u7684\u589e\u52a0\uff0c\u4ece\u800c\u786e\u4fdd\u81ea\u8eab\u4e0d\u65ad\u5730\u8d70\u5411\u66f4\u9ad8\u5c42\u6b21\u7684\u7a33\u5b9a\u6709\u5e8f\u7ed3\u6784[7]\u3002\u666e\u5229\u9ad8\u6d25\u56e0\u6b64\u5728 1977 \u83b7\u5f97\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u3002<\/span><\/section>\n
     <\/span><\/section>\n
    \n
    \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
    Thermodynamic Theory of Structure\uff0c Stability and Fluctuations.<\/span><\/section>\n
    \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
    https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/bbpc.19720760520<\/section>\n<\/blockquote>\n

    \n

    <\/section>\n

    <\/span><\/section>\n
    \u827e\u6839\uff1a\u8d85\u5faa\u73af\u7406\u8bba<\/strong><\/span><\/section>\n<\/h3>\n

    <\/span><\/section>\n
    \u827e\u6839\uff08Manfred Eigen\uff0c1927-2019\uff09\uff0c1967\u5e74\u83b7\u5f97\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u3002\u8d85\u5faa\u73af\u662f\u4e00\u79cd\u81ea\u7136\u81ea\u7ec4\u7ec7\u7684\u539f\u7406\uff0c\u5141\u8bb8\u4e00\u7ec4\u529f\u80fd\u8026\u5408\u7684\u81ea\u4ee3\u8868\u5b9e\u4f53\u7684\u8fde\u7eed\u4e00\u81f4\u6f14\u5316\u3002\u8d85\u5faa\u73af\u662f\u4e00\u7c7b\u65b0\u9896\u7684\u975e\u7ebf\u6027\u53cd\u5e94\u7f51\u7edc\uff0c\u5b83\u662f\u4e00\u4e2a\u80fd\u591f\u81ea\u6211\u6307\u5bfc\u81ea\u8eab\u590d\u5236\u7684\u6574\u4f53\uff0c\u5e76\u4e3a\u4e0b\u4e00\u4e2a\u5faa\u73af\u7684\u590d\u5236\u63d0\u4f9b\u4e86\u50ac\u5316\u652f\u6301[8] [9]\u3002\u5982\u4e0b\u56fe\u6240\u793a\uff0c\u4fe1\u606f\u8f7d\u4f53 I \u4e0d\u4ec5\u5305\u542b\u4e86\u81ea\u8eab\u590d\u5236\u7684\u4fe1\u606f\uff0c\u8fd8\u5305\u542b\u4e86\u5177\u6709\u4fc3\u4f7f\u8f6c\u5316\u6210\u5176\u4ed6\u7c7b\u578b\u6240\u5bf9\u5e94\u529f\u80fd\u7279\u6027\u7684\u5a92\u4ecb\u7269 E\uff08\u901a\u5e38\u662f\u4e00\u79cd\u9176\uff09\u7684\u4fe1\u606f\u3002\u8fd9\u79cd\u7531\u8f7d\u4f53\u4fe1\u606f\u751f\u6210\u7684\u9176\uff0c\u652f\u6301\u4e86\u4e0b\u4e00\u4e2a\u4fe1\u606f\u8f7d\u4f53\u7684\u6d3b\u6027\u3002\u4e00\u4e2a\u8d85\u50ac\u5316\u5faa\u73af\u7531\u82e5\u5e72\u7f51\u72b6\u7684\u50ac\u5316\u5faa\u73af\u5f62\u6210\uff0c\u5fc5\u987b\u7684\u4e24\u79cd\u529f\u80fd\u662f\uff0c\u6bcf\u4e2a\u5faa\u73af\u80fd\u591f\u81ea\u6211\u590d\u5236\uff0c\u5e76\u4e14\u4e00\u4e2a\u5faa\u73af\u7684\u4ea7\u7269\u5fc5\u987b\u652f\u6301\u4e0b\u4e00\u4e2a\u5faa\u73af\u3002<\/span><\/section>\n

    <\/section>\n
    <\/section>\n
    \u56fe9\uff1a\u8d85\u5faa\u73af\u662f\u4e00\u79cd\u81ea\u6211\u590d\u5236\u7684\u5927\u5206\u5b50\u7cfb\u7edf\uff0c\u5176\u4e2d RNA\uff08I\uff09\u548c\u9176\uff08E\uff09\u7684\u534f\u540c\u4f5c\u7528\u3002<\/span><\/strong><\/span><\/section>\n

    <\/span><\/section>\n
    \n
    \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
    Self organization of matter and the evolution of biological macromolecules<\/span><\/section>\n
    \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
    https:\/\/link.springer.com\/article\/10.1007\/BF00623322 <\/section>\n<\/blockquote>\n
    \n
    \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
    The Hypercycle: A principle of natural self-organization<\/span><\/section>\n
    \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
    https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/qua.560140722<\/section>\n<\/blockquote>\n

    \n

    <\/section>\n

    <\/span><\/section>\n
    \u80e1\u5fb7<\/strong><\/span><\/section>\n

    <\/span><\/section>\n<\/h3>\n
    \u4f5c\u4e3a\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u7684\u53d1\u8d77\u4eba\u4e4b\u4e00\uff0c\u7f8e\u56fd\u79d1\u5b66\u5bb6\u83b1\u8bfa\u4f0a\u00b7\u80e1\u5fb7\uff08Leroy Hood\uff09\u4e5f\u662f\u7ec4\u5b66 \uff08Omics\uff09 \u751f\u7269\u6280\u672f\u5f00\u521b\u8005\u4e4b\u4e00\u3002\u80e1\u5fb7\u5df2\u7ecf\u5f00\u53d1\u4e86\u7a81\u7834\u6027\u7684\u79d1\u5b66\u4eea\u5668\uff0c\u4f7f\u751f\u7269\u79d1\u5b66\u548c\u533b\u5b66\u79d1\u5b66\u7684\u91cd\u5927\u8fdb\u5c55\u6210\u4e3a\u53ef\u80fd\u3002\u8fd9\u4e9b\u5305\u62ec\u7528\u4e8e\u786e\u5b9a\u7ec4\u6210\u7ed9\u5b9a\u86cb\u767d\u8d28\u7684\u6c28\u57fa\u9178\u7684\u7b2c\u4e00\u6c14\u76f8\u86cb\u767d\u8d28\u6d4b\u5e8f\u5668\uff0cDNA \u5408\u6210\u5668\uff0c\u7528\u6765\u5408\u6210 DNA \u7684\u77ed\u7247\u6bb5\uff0c\u80bd\u5408\u6210\u5668\uff0c\u5c06\u6c28\u57fa\u9178\u7ed3\u5408\u6210\u8f83\u957f\u7684\u80bd\u548c\u8f83\u77ed\u7684\u86cb\u767d\u8d28\uff0c\u7b2c\u4e00\u4e2a\u81ea\u52a8DNA\u6d4b\u5e8f\u5668[10] [11]\u3002<\/span><\/section>\n

    <\/span><\/section>\n
    \n
    \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
    The digital code of DNA<\/span><\/section>\n
    \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
    https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12540920<\/section>\n<\/blockquote>\n
    \n
    \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
    Systems Biology and New Technologies Enable Predictive and Preventative Medicine<\/span><\/section>\n
    \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
    https:\/\/api.semanticscholar.org\/CorpusID:33015388<\/section>\n<\/blockquote>\n

    \n

    <\/section>\n

    <\/span><\/section>\n
    \u66fe\u90a6\u54f2<\/span><\/strong><\/span><\/section>\n

    <\/span><\/section>\n<\/h3>\n
    1996 \u5e74\u5728\u5317\u4eac\u4e3e\u529e\u7684\u7b2c 1 \u5c4a\u56fd\u9645\u8f6c\u57fa\u56e0\u52a8\u7269\u5b66\u672f\u7814\u8ba8\u4f1a\uff0c\u4e2d\u79d1\u9662\u66fe\u90a6\u54f2\u9610\u8ff0\u4e86\u7cfb\u7edf\u8bba\u4e0e\u751f\u7269\u9057\u4f20\u5b66\u3001\u8f6c\u57fa\u56e0\u7814\u7a76\u7b49\uff0c1999 \u5e74\u5143\u6708\u4e8e\u5fb7\u56fd\u5efa\u7acb\u4e86\u7cfb\u7edf\u751f\u7269\u79d1\u5b66\u4e0e\u5de5\u7a0b\u7f51\uff08http:\/\/www.sysbioeng.com\/genozen\/project.html\uff09\u8868\u8ff0\u751f\u7269\u7cfb\u7edf\u7ed3\u6784\u8bba\uff08Structurity theory\uff09\u7684\u7ed3\u6784\u6574\u5408 \uff08Integrative\uff09\u3001\u8c03\u9002\u7a33\u6001\uff08Stability\uff09\u4e0e\u5c42\u7ea7\u5efa\u6784\uff08Constructive\uff09 \u7b49\u7efc\u5408\uff08Synthetic\uff09\u7cfb\u7edf\u7406\u8bba\u89c4\u5f8b\uff0c\u5e76\u5b9a\u4e49\u5b9e\u9a8c\u3001\u8ba1\u7b97\u7cfb\u7edf\u7814\u7a76\uff0c\u540c\u7cfb\u7edf\u79d1\u5b66\u3001\u8ba1\u7b97\u673a\u79d1\u5b66\u3001\u7eb3\u7c73\u79d1\u5b66\u548c\u751f\u7269\u533b\u5b66\u3001\u751f\u7269\u5de5\u7a0b\u7b49\u9886\u57df\u56fd\u9645\u79d1\u5b66\u5bb6\u5e7f\u6cdb\u901a\u8baf\uff0c\u5021\u5bfc\u5206\u5b50\u751f\u7269\u6280\u672f\u548c\u8ba1\u7b97\u673a\u79d1\u5b66 -\u5b9e\u9a8c\u751f\u7269\u5b66\u5bb6\u4e0e\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6\u7ed3\u5408\u7814\u7a76\u751f\u7269\u7cfb\u7edf\uff0c\u5524\u8d77\u4e86\u4e00\u5927\u6279\u751f\u7269\u5b66\u7814\u7a76\u9886\u57df\u4ee5\u5916\u7684\u4e13\u5bb6\u7684\u5173\u6ce8\u3002<\/span><\/section>\n
     <\/span><\/section>\n

    <\/span><\/section>\n

    \n
    \u5317\u91ce\u5b8f\u660e<\/strong><\/span><\/section>\n

    <\/strong><\/span><\/section>\n<\/h3>\n
    1999 \u5e74\u66f4\u65e9\u7684\u4e2d\u671f\u4e0d\u5c11\u79d1\u5b66\u5bb6\u5f00\u59cb\u4e86\u8bba\u8ff0\uff0c2000 \u5e74\u65e5\u672c\u4e3e\u529e\u4e86\u56fd\u9645\u7cfb\u7edf\u751f\u7269\u5b66\u4f1a\u8bae\uff0c\u968f\u540e\uff0c\u7cfb\u7edf\u751f\u7269\u5b66\u4fbf\u9010\u6e10\u91cd\u65b0\u5f97\u5230\u4e86\u751f\u7269\u79d1\u5b66\u754c\u7684\u8ba4\u540c\u30022002 \u5e74\u65e5\u672c\u5317\u91ce\u5b8f\u660e\uff08Kitano H.\uff09\u4e5f\u8bba\u8ff0\u4e86\u7cfb\u7edf\u751f\u7269\u5b66\u662f\u5b9e\u9a8c\u4e0e\u8ba1\u7b97\u65b9\u6cd5\u6574\u5408\u7684\u751f\u7269\u7cfb\u7edf\u7814\u7a76[12] [13]\u3002<\/span><\/section>\n
     <\/span><\/section>\n
    \n
    \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
    Computational systems biology<\/span><\/section>\n
    \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
    https:\/\/doi.org\/10.1038\/nature01254<\/section>\n<\/blockquote>\n
     <\/span><\/section>\n
    \n
    \u8bba\u6587\u6807\u9898\uff1a<\/span><\/section>\n
    The systems biology markup language \uff08SBML\uff09: a medium for representation and exchange of biochemical network models<\/span><\/section>\n
    \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
    https:\/\/doi.org\/10.1093\/bioinformatics\/btg015<\/section>\n<\/blockquote>\n
     <\/span><\/section>\n
    2004 \u7684\u7efc\u8ff0\u91cc\u9610\u8ff0\u4e86\u751f\u7269\u7cfb\u7edf\u7684\u9c81\u68d2\u6027\uff1a\u9c81\u68d2\u6027\u662f\u751f\u7269\u7cfb\u7edf\u666e\u904d\u5b58\u5728\u7684\u7279\u6027\u3002\u5b83\u88ab\u8ba4\u4e3a\u662f\u590d\u6742\u6f14\u5316\u7cfb\u7edf\u7684\u4e00\u4e2a\u57fa\u672c\u7279\u5f81\u3002\u5b83\u662f\u901a\u8fc7\u5bf9\u751f\u7269\u6709\u673a\u4f53\u548c\u590d\u6742\u5de5\u7a0b\u7cfb\u7edf\u666e\u904d\u9002\u7528\u7684\u51e0\u4e2a\u57fa\u672c\u539f\u5219\u6765\u5b9e\u73b0\u7684\u3002\u9c81\u68d2\u6027\u4fc3\u8fdb\u4e86\u53ef\u8fdb\u5316\u6027\uff0c\u800c\u9c81\u68d2\u6027\u7279\u5f81\u901a\u5e38\u662f\u7531\u8fdb\u5316\u9009\u62e9\u7684[14]\u3002<\/span><\/section>\n
     <\/span><\/section>\n
    \n
    \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
    Biological robustness<\/span><\/section>\n
    \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
    https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15520792<\/section>\n<\/blockquote>\n

    <\/section>\n

    <\/section>\n
    \u5408\u6210\u751f\u7269\u5b66<\/span><\/strong><\/span><\/section>\n
     <\/span><\/section>\n
    2000 \u5e74\u7f8e\u56fd E. Kool  \u57fa\u4e8e\u7cfb\u7edf\u751f\u7269\u5b66\u7684\u57fa\u56e0\u5de5\u7a0b\uff0c\u91cd\u65b0\u63d0\u51fa\u5408\u6210\u751f\u7269\u5b66\uff08Synthetic biology\uff09\u3002<\/span><\/section>\n
     <\/span><\/section>\n
    \u5408\u6210\u751f\u7269\u5b66\u662f\u4e00\u95e8\u5c06\u79d1\u5b66\u4e0e\u5de5\u7a0b\u76f8\u7ed3\u5408\uff0c\u4ee5\u8bbe\u8ba1\u548c\u6784\u5efa\u65b0\u7684\u751f\u7269\u529f\u80fd\u548c\u7cfb\u7edf\u7684\u751f\u7269\u5b66\u7814\u7a76\u65b0\u9886\u57df\u3002\u5408\u6210\u751f\u7269\u5b66\u7684\u5b9a\u4e49\u5df2\u88ab\u666e\u904d\u63a5\u53d7\u4e3a\u751f\u7269\u5b66\u5de5\u7a0b:\u7efc\u5408\u590d\u6742\u7684\u3001\u57fa\u4e8e\u751f\u7269\u5b66\u7684\uff08\u6216\u542f\u53d1\u7684\uff09\u7cfb\u7edf\uff0c\u8fd9\u4e9b\u7cfb\u7edf\u663e\u793a\u4e86\u81ea\u7136\u754c\u4e2d\u4e0d\u5b58\u5728\u7684\u529f\u80fd\u3002\u8fd9\u79cd\u5de5\u7a0b\u5b66\u7684\u89c2\u70b9\u53ef\u4ee5\u5e94\u7528\u4e8e\u751f\u7269\u7ed3\u6784\u7684\u5404\u4e2a\u5c42\u6b21\uff0c\u4ece\u5355\u4e2a\u5206\u5b50\u5230\u6574\u4e2a\u7ec6\u80de\u3001\u7ec4\u7ec7\u548c\u751f\u7269\u4f53[15]\u3002<\/span><\/section>\n
     <\/span><\/section>\n
    \n
    \u4e13\u8457\u9898\u76ee\uff1a<\/span><\/section>\n
    Synthetic Biology\uff0c Volume 1<\/span><\/section>\n
    \u4e13\u8457\u5730\u5740\uff1a<\/section>\n
    https:\/\/www.overdrive.com\/media\/2502000\/synthetic-biology-volume-1<\/section>\n<\/blockquote>\n
     <\/span><\/section>\n
    \u5408\u6210\u751f\u7269\u5b66\u5bb6\u5206\u4e3a\u4e24\u5927\u7c7b\u3002\u4e00\u79cd\u4f7f\u7528\u975e\u81ea\u7136\u5206\u5b50\u6765\u91cd\u73b0\u81ea\u7136\u751f\u7269\u5b66\u4e2d\u51fa\u73b0\u7684\u884c\u4e3a\uff0c\u76ee\u7684\u662f\u521b\u9020\u4eba\u5de5\u751f\u547d\u3002\u53e6\u4e00\u79cd\u5219\u4ece\u81ea\u7136\u751f\u7269\u5b66\u4e2d\u5bfb\u627e\u53ef\u4e92\u6362\u7684\u90e8\u5206\uff0c\u5c06\u5176\u7ec4\u5408\u6210\u975e\u81ea\u7136\u529f\u80fd\u8fd0\u884c\u7684\u7cfb\u7edf[16]\u3002<\/span><\/section>\n
     <\/span><\/section>\n
    \n
    \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
    Synthetic Biology<\/span><\/section>\n
    \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
    http:\/\/dx.doi.org\/10.1038\/nrg1637<\/section>\n<\/blockquote>\n
     <\/span><\/section>\n
    2008 \u5e74 Nature \u6587\u7ae0\u5219\u8bba\u8ff0\u4e86\u7cfb\u7edf\u751f\u7269\u5b66\u4e0e\u5408\u6210\u751f\u7269\u5b66\u7684\u7ed3\u6784\u7406\u8bba[17]\u3002<\/span><\/section>\n
     <\/span><\/section>\n
    \n
    \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
    Systems and Synthetic biology: tackling genetic networks and complex diseases<\/span><\/section>\n
    \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
    https:\/\/www.nature.com\/articles\/hdy200918<\/section>\n<\/blockquote>\n

    \n

    <\/section>\n

    <\/span><\/section>\n
    \u751f\u7269\u4fe1\u606f\u5b66<\/strong><\/span><\/section>\n

    <\/strong><\/span><\/section>\n<\/h3>\n
    \u751f\u7269\u4fe1\u606f\u5b66\uff08Bioinformatics\uff09\u5305\u62ec\u5f00\u53d1\u548c\u5e94\u7528\u8f6f\u4ef6\u5de5\u5177\uff0c\u4ee5\u5e2e\u52a9\u7406\u89e3\u751f\u7269\u529f\u80fd\u548c\u6570\u636e\uff0c\u800c\u7cfb\u7edf\u751f\u7269\u5b66\u6d89\u53ca\u6570\u5b66\u548c\u8ba1\u7b97\u5efa\u6a21\u7684\u751f\u7269\u7cfb\u7edf\u548c\u529f\u80fd\uff0c\u4ee5\u7b80\u5316\u8868\u793a\uff0c\u7406\u89e3\u548c\u6587\u6863\u3002\u751f\u7269\u4fe1\u606f\u5b66\u6574\u5408\u548c\u5e94\u7528\u7edf\u8ba1\u5b66\u3001\u6570\u5b66\u3001\u8ba1\u7b97\u673a\u79d1\u5b66\u3001\u5de5\u7a0b\u548c\u751f\u7269\u5b66\u7684\u7406\u8bba\u548c\u5b9e\u8df5\u77e5\u8bc6\uff0c\u5e76\u5141\u8bb8\u5728\u751f\u7269\u6570\u636e\u7684\u7535\u8111\u5206\u6790\u548c\u8ba1\u7b97\u673a\u5316\u89e3\u91ca\u7684\u6570\u636e\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u7cfb\u7edf\u751f\u7269\u5b66\u5229\u7528\u4fe1\u53f7\u901a\u8def\u3001\u4ee3\u8c22\u7f51\u7edc\u548c\u57fa\u56e0\u5e8f\u5217\u529f\u80fd\u7684\u77e5\u8bc6\uff0c\u4ee5\u4fc3\u8fdb\u79d1\u5b66\u7684\u7814\u7a76\u548c\u5e94\u7528\u3002<\/span><\/section>\n
     <\/span><\/section>\n
    \u751f\u7269\u4fe1\u606f\u5b66\u6700\u65e9\u51fa\u73b0\u5728 50 \u591a\u5e74\u524d\uff0c\u5f53\u65f6\u53f0\u5f0f\u7535\u8111\u8fd8\u53ea\u662f\u4e00\u79cd\u5047\u8bbe\uff0cDNA \u8fd8\u65e0\u6cd5\u6d4b\u5e8f\u300220 \u4e16\u7eaa 60 \u5e74\u4ee3\uff0c\u7b2c\u4e00\u4e2a\u65b0\u7684\u80bd\u5e8f\u5217\u7ec4\u88c5\u5668\u3001\u7b2c\u4e00\u4e2a\u86cb\u767d\u8d28\u5e8f\u5217\u6570\u636e\u5e93\u548c\u7b2c\u4e00\u4e2a\u7528\u4e8e\u7cfb\u7edf\u53d1\u80b2\u7684\u6c28\u57fa\u9178\u66ff\u4ee3\u6a21\u578b\u88ab\u5f00\u53d1\u51fa\u6765\u3002\u5728 20 \u4e16\u7eaa 70 \u5e74\u4ee3\u548c 80 \u5e74\u4ee3\uff0c\u5206\u5b50\u751f\u7269\u5b66\u548c\u8ba1\u7b97\u673a\u79d1\u5b66\u7684\u5e76\u884c\u53d1\u5c55\u4e3a\u5206\u6790\u5168\u57fa\u56e0\u7ec4\u7b49\u65e5\u76ca\u590d\u6742\u7684\u5de5\u4f5c\u94fa\u5e73\u4e86\u9053\u8def\u3002\u5728 1990 \u5e74\u7684 21 \u4e16\u7eaa\u5934\u5341\u5e74\uff0c\u4e92\u8054\u7f51\u7684\u4f7f\u7528\uff0c\u52a0\u4e0a\u4e8c\u4ee3\u6d4b\u5e8f\uff0c\u5bfc\u81f4\u4e86\u6570\u636e\u7684\u6307\u6570\u589e\u957f\u548c\u751f\u7269\u4fe1\u606f\u5b66\u5de5\u5177\u7684\u8fc5\u901f\u53d1\u5c55\u3002\u4eca\u5929\uff0c\u751f\u7269\u4fe1\u606f\u5b66\u9762\u4e34\u7740\u591a\u79cd\u6311\u6218\uff0c\u5982\u5904\u7406\u5927\u6570\u636e\u3001\u786e\u4fdd\u7ed3\u679c\u7684\u518d\u73b0\u6027\u4ee5\u53ca\u4e0e\u5b66\u672f\u9886\u57df\u7684\u6070\u5f53\u4ea4\u878d[18]\u3002<\/span><\/section>\n
     <\/span><\/section>\n
    \u739b\u683c\u4e3d\u7279\u00b7\u8fbe\u970d\u592b\uff08Margaret Dayhoff\uff0c1925-1983\uff09\u662f\u4e00\u4f4d\u7f8e\u56fd\u7269\u7406\u5316\u5b66\u5bb6\uff0c\u5979\u7387\u5148\u5c06\u8ba1\u7b97\u673a\u65b9\u6cd5\u5e94\u7528\u4e8e\u751f\u7269\u5316\u5b66\u9886\u57df[19]\u3002<\/span><\/section>\n
     <\/span><\/section>\n
    \n
    \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
    Digital electronic computers in biomedical science.<\/span><\/section>\n
    \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
    https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14415153<\/section>\n<\/blockquote>\n

    <\/section>\n

    <\/p>\n

    \u56fe10\uff1aNCBI \u57fa\u56e0\u5e93\u548c WGS\uff08Whole Genome Shotgun\uff0c\u5168\u57fa\u56e0\u7ec4\u9e1f\u67aa\u6cd5\uff09\u6570\u636e\u5e93\u4e2d\u968f\u65f6\u95f4\u53d8\u5316\u7684\u5e8f\u5217\u603b\u6570\u3002<\/span><\/strong><\/span><\/p>\n

     <\/span><\/section>\n
    \u5728 1990 \u5e74\u4ee3\u5230 2000 \u5e74\u4ee3\uff0c\u6d4b\u5e8f\u6280\u672f\u7684\u91cd\u5927\u6539\u8fdb\u4ee5\u53ca\u6210\u672c\u7684\u964d\u4f4e\u4f7f\u6570\u636e\u5448\u6307\u6570\u7ea7\u589e\u957f\u3002\u81ea 2008 \u5e74\u4ee5\u6765\uff0c\u6469\u5c14\u5b9a\u5f8b\u4e0d\u518d\u662f DNA \u6d4b\u5e8f\u6210\u672c\u7684\u51c6\u786e\u9884\u6d4b\u6307\u6807\uff0c\u5728\u5927\u89c4\u6a21\u5e76\u884c\u6d4b\u5e8f\u6280\u672f\u51fa\u73b0\u540e\uff0c\u6469\u5c14\u5b9a\u5f8b\u964d\u4f4e\u4e86\u51e0\u4e2a\u6570\u91cf\u7ea7\u3002<\/span><\/section>\n

    <\/span><\/section>\n
    \u867d\u7136\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u6839\u636e\u5fc5\u8981\u7684\u8ba1\u7b97\uff0c\u4e00\u53f0\u7b80\u5355\u7684\u53f0\u5f0f\u8ba1\u7b97\u673a\u5c31\u8db3\u591f\u4e86\uff0c\u4f46\u751f\u7269\u4fe1\u606f\u5b66\u7684\u4e00\u4e9b\u9879\u76ee\u5c06\u9700\u8981\u66f4\u5e9e\u5927\u3001\u6602\u8d35\u548c\u9700\u8981\u4e13\u95e8\u77e5\u8bc6\u7684\u57fa\u7840\u8bbe\u65bd\u3002\u4e00\u4e9b\u653f\u5e9c\u8d44\u52a9\u7684\u4e13\u95e8\u4ece\u4e8b\u9ad8\u6027\u80fd\u8ba1\u7b97\u7684\u7ec4\u7ec7\u5df2\u7ecf\u51fa\u73b0\uff0c\u4f8b\u5982\uff1a<\/span><\/section>\n

    <\/span><\/section>\n
      \n
    • \n
      Compute Canada \uff08https:\/\/www.computecanada.ca\uff09<\/span><\/section>\n<\/li>\n
    • \n
      New York State\u2019s High Performance Computing Program<\/span><\/section>\n
      \uff08https:\/\/esd.ny.gov\/new-york-state-high-performance<\/span><\/section>\n
      -computingprogram\uff09<\/span><\/section>\n<\/li>\n
    • \n
      The European Technology Platform for High Performance Computing \uff08http:\/\/www.etp4hpc.eu\/\uff09<\/span><\/section>\n<\/li>\n
    • \n
      China\u2019s National Center for High-Performance Computing \uff08http:\/\/www.nchc.org.tw\/en\/\uff09<\/span><\/section>\n<\/li>\n<\/ul>\n
             <\/span><\/section>\n
      <\/section>\n

      \u56fe11\uff1a\u4e00\u4e9b\u751f\u7269\u4fe1\u606f\u5b66\u4e2d\u4f7f\u7528\u7684\u975e\u811a\u672c\u548c\/\u6216\u7edf\u8ba1\u7f16\u7a0b\u8bed\u8a00\uff0c\u4ee5\u53ca\u5e94\u7528\u8f6f\u4ef6\u548c\u7a0b\u5e8f\u5305[18]\u3002<\/span><\/strong><\/span><\/p>\n

      \n

      <\/section>\n

      <\/section>\n
      Science \u5408\u96c6<\/strong><\/span><\/section>\n

      <\/span><\/section>\n<\/h3>\n
      2002 \u5e7403 \u6708\uff0c\u7f8e\u56fd\u300aScience\u300b\u5468\u520a\u767b\u8f7d\u4e86\u7cfb\u7edf\u751f\u7269\u5b66\u4e13\u96c6\uff08\u94fe\u63a5\uff1ahttp:\/\/science.sciencemag.org\/content\/295\/5560<\/span>\uff09\uff0c\u8be5\u4e13\u96c6\u5bfc\u8bba\u4e2d\u7684\u7b2c\u4e00\u53e5\u8bdd\u8fd9\u6837\u5199\u9053\uff1a\u201c\u5982\u679c\u5bf9\u5f53\u524d\u6d41\u884c\u7684\u3001\u524d\u6cbf\u7684\u5173\u952e\u8bcd\u8fdb\u884c\u4e00\u756a\u5206\u6790\uff0c\u90a3\u4e48\u4eba\u4eec\u4f1a\u53d1\u73b0\uff0c\u2018\u7cfb\u7edf\u2019\u9ad8\u5c45\u5728\u6392\u884c\u699c\u4e0a\u3002\u201d\u4e13\u9898\u4e2d\u5305\u542b\u56db\u7bc7\u7efc\u8ff0\u8bba\u6587\uff1a<\/span><\/section>\n
       <\/span><\/section>\n
      <\/section>\n
      \u56fe12\uff1a\u4e13\u9898\u5c01\u9762\u56fe\uff1a\u4ee5\u6a21\u5757\u5316\u95fb\u540d\u7684\u4e50\u9ad8\u79ef\u6728\uff0c\u662f\u5bf9\u751f\u7269\u67b6\u6784\u548c\u52a8\u6001\u8fc7\u7a0b\u4e00\u4e2a\u6070\u5f53\u7684\u6bd4\u55bb\uff0c\u5305\u62ec\u4ece\u57fa\u56e0\u8868\u8fbe\u5230\u7ec4\u7ec7\u548c\u6709\u673a\u4f53\u7684\u529f\u80fd\u5404\u4e2a\u5c42\u6b21\uff0c\u7ec4\u4ef6\u4e4b\u95f4\u7684\u8054\u7cfb\u3001\u5982\u4f55\u88ab\u7ba1\u7406\u7684\uff0c\u4ee5\u53ca\u5b83\u4eec\u662f\u5982\u4f55\u8fdb\u5316\u7684\u3002\u8fd9\u4e9b\u90fd\u662f\u7406\u89e3\u4e0d\u540c\u5c42\u6b21\u751f\u7269\u590d\u6742\u6027\u7684\u5173\u952e\u3002<\/span><\/strong><\/span><\/section>\n

      <\/span><\/section>\n
      \u7b2c\u4e00\u7bc7\u662f\u6709\u5317\u91ce\u5b8f\u660e\u6240\u4f5c\uff0c\u9610\u8ff0\u4e86\u4ece\u7cfb\u7edf\u7684\u5c42\u9762\u7406\u89e3\u751f\u7269\u5b66<\/strong>\uff0c\u6211\u4eec\u5fc5\u987b\u7814\u7a76\u7ec6\u80de\u548c\u6709\u673a\u4f53\u529f\u80fd\u7684\u7ed3\u6784\u548c\u52a8\u6001\uff0c\u800c\u4e0d\u662f\u7ec6\u80de\u6216\u6709\u673a\u4f53\u7684\u5b64\u7acb\u90e8\u5206\u7684\u7279\u5f81\u3002\u7cfb\u7edf\u7684\u7279\u6027\uff0c\u5982\u9c81\u68d2\u6027\uff0c\u6210\u4e3a\u4e2d\u5fc3\u95ee\u9898\uff0c\u4e86\u89e3\u8fd9\u4e9b\u7279\u6027\u53ef\u80fd\u4f1a\u5bf9\u533b\u5b66\u7684\u672a\u6765\u4ea7\u751f\u5f71\u54cd\u3002\u7136\u800c\uff0c\u5728\u7cfb\u7edf\u751f\u7269\u5b66\u7684\u6210\u5c31\u80fd\u591f\u53d1\u6325\u5176\u5907\u53d7\u5439\u6367\u7684\u6f5c\u529b\u4e4b\u524d\uff0c\u9700\u8981\u5728\u5b9e\u9a8c\u88c5\u7f6e\u3001\u5148\u8fdb\u8f6f\u4ef6\u548c\u5206\u6790\u65b9\u6cd5\u4e0a\u53d6\u5f97\u8bb8\u591a\u7a81\u7834[20]\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      Systems Biology: A Brief Overview<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/science.sciencemag.org\/content\/295\/5560\/1662<\/section>\n<\/blockquote>\n

      <\/span><\/section>\n
      \u7b2c\u4e8c\u7bc7\u7efc\u8ff0\u4ece\u5de5\u7a0b\u7406\u8bba\u548c\u5b9e\u8df5\u4e2d\u9610\u660e\u4e00\u4e9b\u751f\u7269\u590d\u6742\u6027\u7684\u89c1\u89e3<\/strong>\u3002\u5148\u8fdb\u7684\u6280\u672f\u548c\u751f\u7269\u5b66\u6709\u7740\u622a\u7136\u4e0d\u540c\u7684\u7269\u7406\u5b9e\u73b0\uff0c\u4f46\u5b83\u4eec\u5728\u7cfb\u7edf\u7ea7\u7ec4\u7ec7\u65b9\u9762\u7684\u76f8\u4f3c\u4e4b\u5904\u8fdc\u6bd4\u4eba\u4eec\u666e\u904d\u8ba4\u4e3a\u7684\u8981\u591a\u3002\u8fd9\u4e24\u4e2a\u9886\u57df\u7684\u8d8b\u540c\u6f14\u5316\u4ea7\u751f\u4e86\u7531\u534f\u8bae\u7684\u7cbe\u7ec6\u5c42\u6b21\u7ed3\u6784\u548c\u53cd\u9988\u8c03\u8282\u5c42\u7ec4\u6210\u7684\u6a21\u5757\u5316\u67b6\u6784\uff0c\u8fd9\u4e9b\u67b6\u6784\u662f\u7531\u5bf9\u4e0d\u786e\u5b9a\u73af\u5883\u7684\u9c81\u68d2\u6027\u9700\u6c42\u9a71\u52a8\u7684\uff0c\u5e76\u4e14\u7ecf\u5e38\u4f7f\u7528\u4e0d\u7cbe\u786e\u7684\u7ec4\u4ef6\u3002\u8fd9\u4e9b\u4ee4\u4eba\u56f0\u60d1\u548c\u77db\u76fe\u7684\u7279\u5f81\u65e2\u4e0d\u662f\u5076\u7136\u7684\uff0c\u4e5f\u4e0d\u662f\u4eba\u4e3a\u7684\uff0c\u800c\u662f\u6e90\u4e8e\u590d\u6742\u6027\u548c\u9c81\u68d2\u6027\u3001\u6a21\u5757\u5316\u3001\u53cd\u9988\u548c\u8106\u5f31\u6027\u4e4b\u95f4\u6df1\u523b\u800c\u5fc5\u8981\u7684\u76f8\u4e92\u4f5c\u7528[21]\u3002<\/span><\/section>\n

      <\/span><\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      Reverse Engineering of Biological Complexity<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/science.sciencemag.org\/content\/295\/5560\/1664<\/section>\n<\/blockquote>\n

      <\/span><\/section>\n
      \u7b2c\u4e09\u7bc7\u4ee5<\/strong>\u6d77\u80c6\u4e3a\u4f8b<\/strong>\uff0c\u9610\u8ff0\u4e86\u80da\u80ce\u5185\u80da\u5c42\u548c\u4e2d\u80da\u5c42\u89c4\u683c\u7684\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u3002\u8be5\u7f51\u7edc\u662f\u7531\u5927\u89c4\u6a21\u6270\u52a8\u5206\u6790\uff0c\u7ed3\u5408\u8ba1\u7b97\u65b9\u6cd5\uff0c\u57fa\u56e0\u7ec4\u6570\u636e\uff0c\u987a\u5f0f\u8c03\u63a7\u5206\u6790\uff0c\u548c\u5206\u5b50\u80da\u80ce\u5b66\u3002\u8be5\u7f51\u7edc\u76ee\u524d\u5305\u542b 40 \u591a\u4e2a\u57fa\u56e0\uff0c\u6bcf\u4e2a\u8282\u70b9\u90fd\u53ef\u4ee5\u901a\u8fc7\u987a\u5f0f\u8c03\u63a7\u5206\u6790\u5728 DNA \u5e8f\u5217\u6c34\u5e73\u4e0a\u76f4\u63a5\u9a8c\u8bc1\u3002\u5176\u7ed3\u6784\u4f53\u7cfb\u63ed\u793a\u4e86\u53d1\u80b2\u7684\u5177\u4f53\u548c\u4e00\u822c\u65b9\u9762\uff0c\u4f8b\u5982\u7279\u5b9a\u7684\u7ec6\u80de\u5982\u4f55\u5728\u80da\u80ce\u4e2d\u4ea7\u751f\u5b83\u4eec\u6307\u5b9a\u7684\u547d\u8fd0\uff0c\u4ee5\u53ca\u4e3a\u4ec0\u4e48\u8fd9\u4e00\u8fc7\u7a0b\u5728\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u4e0d\u53ef\u963b\u6321\u5730\u5411\u524d\u53d1\u5c55[22]\u3002<\/span><\/section>\n

      <\/span><\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      A Genomic Regulatory Network for Development<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/science.sciencemag.org\/content\/295\/5560\/1669<\/section>\n<\/blockquote>\n

      <\/span><\/section>\n
      \u7b2c\u56db\u7bc7\u7efc\u8ff0\u4ee5\u5fc3\u810f\u8fd9\u4e00\u5668\u5b98\u4e3a\u4f8b<\/strong>\uff0c\u9610\u8ff0\u4e86\u5668\u5b98\u5efa\u6a21\u7684\u8fdb\u5c55\u3002\u6210\u529f\u7684\u751f\u7406\u5206\u6790\u9700\u8981\u7406\u89e3\u7ec6\u80de\u3001\u5668\u5b98\u548c\u7cfb\u7edf\u7684\u5173\u952e\u7ec4\u6210\u90e8\u5206\u4e4b\u95f4\u7684\u529f\u80fd\u76f8\u4e92\u4f5c\u7528\uff0c\u4ee5\u53ca\u8fd9\u4e9b\u76f8\u4e92\u4f5c\u7528\u5728\u75be\u75c5\u72b6\u6001\u4e2d\u662f\u5982\u4f55\u53d8\u5316\u7684\u3002\u8fd9\u4e9b\u4fe1\u606f\u65e2\u4e0d\u5b58\u5728\u4e8e\u57fa\u56e0\u7ec4\u4e2d\uff0c\u4e5f\u4e0d\u5b58\u5728\u4e8e\u57fa\u56e0\u7f16\u7801\u7684\u5355\u4e2a\u86cb\u767d\u8d28\u4e2d\u3002\u5b83\u5b58\u5728\u4e8e\u4e9a\u7ec6\u80de\u3001\u7ec6\u80de\u3001\u7ec4\u7ec7\u3001\u5668\u5b98\u548c\u7cfb\u7edf\u7ed3\u6784\u4e2d\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7684\u6c34\u5e73\u3002\u56e0\u6b64\uff0c\u9664\u4e86\u590d\u5236\u81ea\u7136\u548c\u8ba1\u7b97\u8fd9\u4e9b\u4ea4\u4e92\u6765\u786e\u5b9a\u5065\u5eb7\u548c\u75c5\u7406\u72b6\u6001\u7684\u903b\u8f91\u4e4b\u5916\uff0c\u6ca1\u6709\u5176\u4ed6\u9009\u62e9\u3002\u751f\u7269\u6570\u636e\u5e93\u7684\u8fc5\u901f\u589e\u957f\uff1b\u7ec6\u80de\u3001\u7ec4\u7ec7\u548c\u5668\u5b98\u6a21\u578b\uff1b\u800c\u5f3a\u5927\u7684\u8ba1\u7b97\u786c\u4ef6\u548c\u7b97\u6cd5\u7684\u53d1\u5c55\u4f7f\u5f97\u4ece\u57fa\u56e0\u5230\u6574\u4e2a\u5668\u5b98\u548c\u8c03\u8282\u7cfb\u7edf\u7684\u751f\u7406\u529f\u80fd\u7684\u5b9a\u91cf\u63a2\u7d22\u529f\u80fd\u6210\u4e3a\u53ef\u80fd[23]\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      Modeling the Heart–from Genes to Cells to the Whole Organ<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/science.sciencemag.org\/content\/295\/5560\/1678<\/section>\n<\/blockquote>\n

      <\/section>\n

      \n
      \n
      \n


      <\/p>\n

      \n
      \n
      <\/p>\n

      \u76f8\u5173\u9886\u57df\u524d\u6cbf\u6587\u7ae0<\/strong><\/span><\/p>\n

      <\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h2>\n

       <\/span><\/section>\n
      \u6839\u636e\u4f7f\u7528\u8de8\u5b66\u79d1\u5de5\u5177\u4ece\u591a\u4e2a\u5b9e\u9a8c\u4e2d\u83b7\u5f97\uff0c\u6574\u5408\u548c\u5206\u6790\u590d\u6742\u6570\u636e\u96c6\u7684\u80fd\u529b\u7684\u7cfb\u7edf\u751f\u7269\u5b66\u89e3\u91ca\uff0c\u4e00\u4e9b\u5178\u578b\u7684\u6280\u672f\u5e73\u53f0<\/strong>\u5305\u62ec\uff1a<\/span><\/section>\n
       <\/span><\/section>\n
      \u57fa\u56e0\u7ec4\u5b66\uff0c\u8868\u89c2\u9057\u4f20\u7ec4\uff0c\u8f6c\u5f55\u7ec4\u5b66\uff0c\u86cb\u767d\u8d28\u7ec4\u5b66\uff0c\u4ee3\u8c22\u7269\u7ec4\u5b66\uff0c\u7cd6\u7ec4\u5b66\uff0c\u8102\u7c7b\u7ec4\u5b66\uff08Lipomics\uff09\uff0c\u9664\u4e86\u4e0a\u8ff0\u7ed9\u5b9a\u5206\u5b50\u7684\u8bc6\u522b\u548c\u91cf\u5316\u4e4b\u5916\uff0c\u8fdb\u4e00\u6b65\u7684\u6280\u672f\u8fd8\u5206\u6790\u7ec6\u80de\u5185\u7684\u52a8\u529b\u5b66\u548c\u76f8\u4e92\u4f5c\u7528\u3002\u5305\u62ec\uff1a\u76f8\u4e92\u4f5c\u7528\u7ec4\u5b66\uff08Interactomics\uff09\uff0c\u4ee3\u8c22\u6d41\u7ec4\u5b66\uff08Fluxomics\uff09\uff0c\u751f\u7269\u7ec4\u5b66\uff08Biomics\uff09\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \u5176\u4ed6\u6280\u672f\u5982\u8ba1\u7b97\u673a\u79d1\u5b66\uff0c\u4fe1\u606f\u5b66\u548c\u7edf\u8ba1\u5b66\u7684\u5176\u4ed6\u65b9\u9762\u4e5f\u7528\u4e8e\u7cfb\u7edf\u751f\u7269\u5b66\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      <\/section>\n
      \u56fe13\uff1a\u591a\u7ec4\u5b66\u65b9\u6cd5\u5bf9\u67d0\u79cd\u7279\u5b9a\u75be\u75c5\u7684\u7814\u7a76\u3002\u7ec4\u5b66\u6570\u636e\u6536\u96c6\u5728\u6574\u4e2a\u5206\u5b50\u6c60\u4e0a\uff0c\u4ee5\u5706\u5708\u8868\u793a\u3002\u9664\u4e86\u57fa\u56e0\u7ec4\u5916\uff0c\u6240\u6709\u7684\u6570\u636e\u5c42\u90fd\u540c\u65f6\u53cd\u6620\u4e86\u9057\u4f20\u8c03\u63a7\u548c\u73af\u5883\uff0c\u8fd9\u53ef\u80fd\u4f1a\u5bf9\u6bcf\u4e2a\u4e2a\u4f53\u5206\u5b50\u4ea7\u751f\u4e0d\u540c\u7a0b\u5ea6\u7684\u5f71\u54cd\u3002\u7ec6\u9ed1\u7bad\u5934\u8868\u793a\u5728\u4e0d\u540c\u5c42\u4e2d\u68c0\u6d4b\u5230\u7684\u5206\u5b50\u4e4b\u95f4\u6f5c\u5728\u7684\u76f8\u4e92\u4f5c\u7528\u6216\u76f8\u5173\u6027\u3002\u4f8b\u5982\uff0c\u7ea2\u8272\u7684\u8f6c\u5f55\u672c\u53ef\u4ee5\u4e0e\u591a\u79cd\u86cb\u767d\u8d28\u76f8\u5173\u8054\u3002\u5728\u540c\u4e00\u5c42\u4e2d\uff0c\u4ea4\u4e92\u4e5f\u5f88\u666e\u904d\uff0c\u56fe\u4e2d\u672a\u8868\u8ff0[24]\u3002<\/span><\/strong><\/span><\/section>\n

      \n

      <\/span><\/section>\n

      <\/section>\n
      \u6c49\u65cf\u4eba\u5168\u57fa\u56e0\u7ec4<\/span><\/strong><\/span><\/section>\n<\/h3>\n

      <\/span><\/section>\n
      \u4e3a\u4e86\u83b7\u5f97\u5168\u9762\u3001\u72ec\u7acb\u3001\u9ad8\u8d28\u91cf\u7684\u4e2d\u56fd\u4eba\u7fa4\u7279\u5f02\u6027\u57fa\u56e0\u7ec4\u6570\u636e\u5e93\uff0c\u4e2d\u56fd\u4ee3\u8c22\u89e3\u6790\u8ba1\u5212ChinaMAP\uff08China Metabolic Analytics Project\uff09\u8bde\u751f\u4e86\u30024\u670830\u65e5\uff0cChinaMAP\u5728\u300aCell Research\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u4e00\u671f\u7814\u7a76\u6210\u679c\uff0c\u9996\u6b21\u62a5\u9053\u4e86\u6765\u81ea\u5168\u56fd 27 \u4e2a\u7701\u4efd\u548c\u76f4\u8f96\u5e02\u30018\u4e2a\u6c11\u65cf\u8d85\u8fc7\u4e00\u4e07\u4eba\u7684\u6df1\u5ea6\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\u5206\u6790\uff0c\u53d1\u73b0\u4e86 1.36 \u4ebf\u4e2a\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff08SNPs\uff09\u548c 1070 \u4e07\u4e2a\u63d2\u5165\u6216\u7f3a\u5931\u4f4d\u70b9\uff08INDEL\uff09\uff0c\u5176\u4e2d\u4e00\u534a\u4ee5\u4e0a\u662f\u672a\u5728\u5176\u4ed6\u6570\u636e\u5e93\u62a5\u9053\u8fc7\u7684\u65b0\u7a81\u53d8[25]\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a <\/span><\/section>\n
      The ChinaMAP analytics of deep whole genome sequences in 10\uff0c588 individuals<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/doi.org\/10.1038\/s41422-020-0322-9<\/section>\n<\/blockquote>\n

      \n

      <\/span><\/section>\n

      <\/span><\/section>\n
      \u53e4DNA\u7ec4\u91cd\u5efa\u4eba\u7c7b\u5386\u53f2<\/strong><\/span><\/section>\n<\/h3>\n

      <\/span><\/section>\n
      \u8be5\u6587\u7cfb\u9996\u6b21\u6b63\u5f0f\u53d1\u8868\u5927\u89c4\u6a21\u4e1c\u4e9a\u5357\u5317\u65b9\u53f2\u524d\u4eba\u7c7b\u57fa\u56e0\u7ec4\u5206\u6790\u7ed3\u679c\uff0c\u4e3a\u63a2\u6e90\u534e\u590f\u65cf\u7fa4\u53ca\u5176\u6587\u5316\u548c\u4fee\u6b63\u4e1c\u4e9a\u5357\u65b9\u4eba\u7fa4\u6f14\u5316\u6a21\u5f0f\u505a\u51fa\u4e86\u91cd\u5927\u8d21\u732e\u3002\u5728\u4e2d\u534e\u6c11\u65cf\u63a2\u6e90\u65b9\u9762\uff0c\u53d1\u73b0\u4e2d\u56fd\u3001\u4e1c\u4e9a\u4e3b\u4f53\u4eba\u7fa4\u8fde\u7eed\u6f14\u5316\u662f\u4e3b\u65cb\u5f8b\uff0c\u4e2d\u56fd\u5357\u5317\u65b9\u53e4\u4eba\u7fa4\u65e9\u5728 9500 \u5e74\u524d\u5df2\u7ecf\u5206\u5316\uff0c\u81f3\u5c11\u5728 8300 \u5e74\u524d\u5357\u5317\u4eba\u7fa4\u878d\u5408\u4e0e\u6587\u5316\u4ea4\u6d41\u7684\u8fdb\u7a0b\u5373\u5df2\u5f00\u59cb\uff0c4800 \u5e74\u524d\u51fa\u73b0\u5f3a\u5316\u8d8b\u52bf\uff0c\u81f3\u4eca\u4ecd\u5728\u5ef6\u7eed[26]\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      American Association for the Advancement of Science<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/www.britannica.com\/topic\/American-Association-for-the-Advancement-of-Science<\/section>\n<\/blockquote>\n
       <\/span><\/section>\n

      <\/span><\/section>\n

      \n
      \u6cdb\u764c\u75c7\u5168\u57fa\u56e0\u7ec4\uff08Pan-cancer Genomics)<\/strong><\/span><\/section>\n<\/h3>\n
       <\/span><\/section>\n
      Nature \u6742\u5fd72020\u5e742\u6708\u4efd\u6574\u7406\u4e86\u6570\u7bc7\u5168\u57fa\u56e0\u7ec4\u7684\u6cdb\u764c\u75c7\u5206\u6790\u7684\u6587\u7ae0\uff08\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/collections\/afdejfafdb<\/span>\uff09\u3002<\/span><\/section>\n

      <\/span><\/section>\n
      \u764c\u75c7\u662f\u4e00\u79cd\u57fa\u56e0\u7ec4\u75be\u75c5\uff0c\u7531\u7ec6\u80de\u83b7\u5f97\u5173\u952e\u764c\u75c7\u57fa\u56e0\u7684\u4f53\u7ec6\u80de\u7a81\u53d8\u5f15\u8d77\u3002\u8fd9\u4e9b\u7a81\u53d8\u6539\u53d8\u4e86\u8c03\u8282\u7ec6\u80de\u751f\u957f\u548c\u4e0e\u7ec4\u7ec7\u73af\u5883\u76f8\u4e92\u4f5c\u7528\u7684\u9014\u5f84\u3002\u76f4\u5230\u6700\u8fd1\uff0c\u5bf9\u764c\u75c7\u57fa\u56e0\u7ec4\u7684\u7814\u7a76\u90fd\u96c6\u4e2d\u5728\u86cb\u767d\u8d28\u7f16\u7801\u57fa\u56e0\u4e0a\uff0c\u8fd9\u4e9b\u57fa\u56e0\u52a0\u8d77\u6765\u53ea\u5360\u57fa\u56e0\u7ec4\u7684 1%\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c ICGC\/TCGA \u5168\u57fa\u56e0\u7ec4\u764c\u75c7\u5206\u6790\uff08PCAWG\uff09\u9879\u76ee\u5bf9\u8d85\u8fc7 2600 \u79cd\u539f\u53d1\u764c\u75c7\u53ca\u5176 38 \u79cd\u4e0d\u540c\u80bf\u7624\u7c7b\u578b<\/strong>\u7684\u6b63\u5e38\u7ec4\u7ec7\u8fdb\u884c\u4e86\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u548c\u7efc\u5408\u5206\u6790\u3002\u8fd9\u9879\u7814\u7a76\u63ed\u793a\u4e86\u5e7f\u6cdb\u7684\u5927\u89c4\u6a21\u7ed3\u6784\u6027\u7a81\u53d8\u5728\u764c\u75c7\u6240\u626e\u6f14\u7684\u89d2\u8272\uff0c\u786e\u5b9a\u8fd9\u79cd\u764c\u75c7\u76f8\u5173\u7684\u7a81\u53d8\u57fa\u56e0\u8c03\u63a7\u533a\u57df\uff0c\u63a8\u6d4b\u80bf\u7624\u8fdb\u5316\u591a\u4e2a\u764c\u75c7\u7c7b\u578b\uff0c\u7167\u4eae\u4e86\u4f53\u7ec6\u80de\u7a81\u53d8\u548c\u8f6c\u5f55\u7ec4\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u548c\u7814\u7a76\u751f\u6b96\u7cfb\u9057\u4f20\u53d8\u5f02\u7684\u4f5c\u7528\u5728\u8c03\u8282\u7a81\u53d8\u8fc7\u7a0b[27] [28] [29]\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      Pan-cancer analysis of whole genomes<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/www.nature.com\/articles\/s41586-020-1969-6 <\/section>\n<\/blockquote>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      Patterns of somatic structural variation in human cancer genomes<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/doi.org\/10.1038\/s41586-019-1913-9 <\/section>\n<\/blockquote>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      Analyses of non-coding somatic drivers in 2\uff0c658 cancer whole genomes<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/doi.org\/10.1038\/s41586-020-1965-x<\/section>\n<\/blockquote>\n

      <\/section>\n

      <\/span><\/section>\n

      \n
      TCGA\u6570\u636e\u5e93<\/strong><\/span><\/section>\n<\/h3>\n

      <\/span><\/section>\n
      2020\u5e745\u670811\u65e5\uff0c\u54c8\u4f5b\u533b\u5b66\u9662\u7684 Andrew D. Cherniack \u548c Rameen Beroukhim \u5408\u4f5c\u53d1\u8868\u6587\u7ae0Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer\uff0c\u901a\u8fc7\u5206\u6790 TCGA \u6570\u636e\u5e93\u7684 33 \u79cd\u764c\u75c7\u7c7b\u578b\u7684 10678 \u540d\u75c5\u60a3\u7684\u7a81\u53d8\u901f\u7387\u3001DNA\u7532\u57fa\u5316\u3001mRNA \u548c miRNA \u8868\u8fbe\uff0c\u9274\u5b9a\u51fa\u4e0e\u764c\u75c7\u76f8\u5173\u7684\u9057\u4f20\u6027\u7956\u5148\u56e0\u7d20\uff08Ancestry effect\uff09[30]\u3002<\/span><\/section>\n

      <\/span><\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer\uff0c Cancer Genome Atlas Analysis Network<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/pubmed.ncbi.nlm.nih.gov\/32396860\/ <\/span><\/section>\n<\/blockquote>\n

      <\/span><\/section>\n
      TCGA \uff08The Cancer Genome Atlas\uff09\u6570\u636e\u5e93 <\/span>https:\/\/portal.gdc.cancer.gov\/ <\/span>\uff0c\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31\uff08TCGA\uff09\u662f\u4e00\u4e2a\u5177\u6709\u91cc\u7a0b\u7891\u610f\u4e49\u7684\u764c\u75c7\u57fa\u56e0\u7ec4\u5b66\u9879\u76ee\uff0c\u5b83\u5bf9 20000 \u591a\u4f8b\u539f\u53d1\u6027\u764c\u75c7\u8fdb\u884c\u4e86\u5206\u5b50\u7279\u5f81\u5206\u6790\uff0c\u5e76\u5bf9 33 \u79cd\u764c\u75c7\u7c7b\u578b\u7684\u6b63\u5e38\u6837\u672c\u8fdb\u884c\u4e86\u5339\u914d\u3002\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\u548c\u56fd\u5bb6\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7814\u7a76\u6240\u7684\u8fd9\u9879\u8054\u5408\u5de5\u7a0b\u59cb\u4e8e 2006 \u5e74\uff0c\u6c47\u96c6\u4e86\u6765\u81ea\u4e0d\u540c\u5b66\u79d1\u548c\u4e0d\u540c\u673a\u6784\u7684\u7814\u7a76\u4eba\u5458\u3002<\/span><\/section>\n

      <\/span><\/section>\n
      <\/section>\n
      \u56fe14\uff1aTCGA \u6570\u636e\u5e93\u9996\u9875\uff0c\u53ef\u4ee5\u6839\u636e\u611f\u5174\u8da3\u7684\u764c\u75c7\u6216\u8005\u57fa\u56e0\u540d\u8fdb\u884c\u68c0\u7d22\u5206\u6790<\/span><\/strong><\/span><\/section>\n

      <\/section>\n

      <\/span><\/section>\n

      \n
      \u764c\u75c7\u4fe1\u53f7\u901a\u8def\u56fe\u8c31<\/span><\/strong><\/span><\/section>\n<\/h3>\n

      <\/span><\/section>\n
      \u764c\u75c7\u7cfb\u7edf\u751f\u7269\u5b66\u7684\u4e00\u4e2a\u5173\u952e\u76ee\u6807\u662f\u5229\u7528\u5927\u6570\u636e\u6765\u9610\u660e\u764c\u75c7\u53d1\u751f\u7684\u5206\u5b50\u7f51\u7edc\u3002\u4f46\u662f\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8fd8\u6ca1\u6709\u7cfb\u7edf\u5730\u8bc4\u4ef7\u8fd9\u4e9b\u52aa\u529b\u53d6\u5f97\u4e86\u591a\u5927\u8fdb\u5c55\u3002\u4e0b\u6587\u4e2d\u4f5c\u8005\u8c03\u67e5\u4e86\u516d\u79cd\u4e3b\u8981\u7684\u7cfb\u7edf\u751f\u7269\u5b66\u65b9\u6cd5\uff0c\u4ee5\u7ed8\u5236\u548c\u5efa\u6a21\u764c\u75c7\u8def\u5f84\uff0c\u5e76\u6ce8\u610f\u5230\u4ed6\u4eec\u7684\u7f51\u7edc\u5730\u56fe\u8986\u76d6\u548c\u589e\u5f3a\u73b0\u6709\u7684\u77e5\u8bc6[31]\u3002<\/span><\/section>\n

      <\/span><\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      A census of pathway maps in cancer systems biology<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/doi.org\/10.1038\/s41568-020-0240-7<\/section>\n<\/blockquote>\n

      <\/span><\/section>\n

      <\/span><\/section>\n

      \n
      \u8868\u89c2\u9057\u4f20\u7ec4\uff08Epigenomics\uff09<\/strong><\/span><\/section>\n<\/h3>\n
       <\/span><\/section>\n
      2019\u5e747\u670810\u65e5\uff0c\u6765\u81ea\u7f8e\u56fd NIH \u7684 Ananda L. Roy \u56e2\u961f\u56de\u987e\u4e86 NIH \u8868\u89c2\u9057\u4f20\u7ec4\u5b66\u84dd\u56fe\u8ba1\u5212\uff08Roadmap\uff09\u542f\u52a8\u7684\u5951\u673a\u548c\u603b\u4f53\u76ee\u6807\uff1b\u4ecb\u7ecd\u4e86\u8868\u89c2\u9057\u4f20\u7ec4\u5b66\u9879\u76ee\u7684\u6210\u679c\uff1a\u53c2\u8003\u8868\u89c2\u9057\u4f20\u7ec4\u3001\u56fd\u9645\u95f4\u8868\u89c2\u9057\u4f20\u7684\u5408\u4f5c\u7814\u7a76\u3001\u75be\u75c5\u7684\u8868\u89c2\u9057\u4f20\u57fa\u7840\u548c\u65b0\u578b\u8868\u89c2\u9057\u4f20\u6807\u5fd7\u7269\u7684\u53d1\u73b0\u3001\u8868\u89c2\u9057\u4f20\u7814\u7a76\u6280\u672f\u7684\u53d1\u5c55\u7b49\uff1b\u603b\u7ed3\u4e86\u9879\u76ee\u5b9e\u884c\u8fc7\u7a0b\u4e2d\u7684\u7ecf\u9a8c\u548c\u6559\u8bad[32]\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      The NIH Common Fund\/Roadmap Epigenomics Program: Successes of a comprehensive consortium<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/doi.org\/10.1126\/sciadv.aaw6507<\/section>\n<\/blockquote>\n
       <\/span><\/section>\n

      <\/span><\/section>\n

      \n
      \u86cb\u767d\u7ec4 \uff08Proteomics\uff09<\/span><\/strong><\/section>\n<\/h3>\n

      <\/section>\n
      \u4eba\u7c7b SRMAtlas\uff1a\u4ee3\u8868\u4eba\u7c7b\u86cb\u767d\u8d28\u7ec4\u7684 166174 \u4e2a\u86cb\u767d\u578b\u80bd\uff0c\u63d0\u4f9b\u4e86\u591a\u79cd\u72ec\u7acb\u7684\u5206\u6790\u65b9\u6cd5\u6765\u91cf\u5316\u4efb\u4f55\u4eba\u7c7b\u86cb\u767d\u548c\u5927\u91cf\u7684\u526a\u63a5\u53d8\u5f02\u3001\u975e\u540c\u4e49\u7a81\u53d8\u548c\u7ffb\u8bd1\u540e\u4fee\u9970[33]\u3002\u672c\u6587\u901a\u8baf\u4f5c\u8005\u4e3a Hood L\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      Human SRMAtlas\uff1aA Resource of Targeted Assays to Quantify the Complete Human Proteome<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867416308492<\/section>\n<\/blockquote>\n

      <\/section>\n
      2020\u5e744\u6708\uff0cNature \u53d1\u8868\u4e86\u4e00\u7bc7\u6587\u7ae0\u4ecb\u7ecd\u4e86\u4e00\u4e2a\u662f\u4e00\u79cd\u7cfb\u7edf\u7684\u5168\u86cb\u767d\u8d28\u53c2\u8003\u5e73\u53f0\uff1aHuRI\uff0c\u5b83\u5c06\u57fa\u56e0\u7ec4\u53d8\u5f02\u4e0e\u8868\u578b\u7ed3\u679c\u8054\u7cfb\u8d77\u6765\u3002\u4e00\u4e2a\u5305\u542b\u7ea6 53000 \u4e2a\u86cb\u767d\u8d28\u4e0e 8000 \u591a\u4e2a\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7684\u4eba\u7c7b\u4e8c\u5143\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u56fe\uff0c\u4e3a\u7814\u7a76\u5065\u5eb7\u548c\u75be\u75c5\u4e2d\u7684\u4eba\u7c7b\u7ec6\u80de\u529f\u80fd\u63d0\u4f9b\u4e86\u53c2\u8003\u3002\u63a8\u6d4b\u7684\u7ec4\u7ec7\u7279\u5f02\u6027\u7f51\u7edc\u63ed\u793a\u4e86\u7ec6\u80de\u73af\u5883\u7279\u5f02\u6027\u529f\u80fd\u5f62\u6210\u7684\u4e00\u822c\u539f\u5219\uff0c\u5e76\u9610\u660e\u53ef\u80fd\u6784\u6210\u5b5f\u5fb7\u5c14\u75be\u75c5\u7ec4\u7ec7\u7279\u5f02\u6027\u8868\u578b\u7684\u6f5c\u5728\u5206\u5b50\u673a\u5236[34]\u3002<\/span><\/section>\n

      <\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      A reference map of the human binary protein interactome<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/www.nature.com\/articles\/s41586-020-2188-x<\/section>\n<\/blockquote>\n
       <\/span><\/section>\n

      <\/span><\/section>\n

      \n
      \u5fae\u751f\u7269\u7ec4\uff08Microbiome\uff09<\/strong><\/span><\/section>\n

      <\/strong><\/span><\/section>\n<\/h3>\n
      \u8bb8\u591a\u6816\u606f\u5728\u4eba\u4f53\u7684\u5fae\u751f\u7269\u4e0e\u4eba\u7c7b\u7684\u5065\u5eb7\u548c\u75be\u75c5\u5bc6\u5207\u76f8\u5173\uff0c\u4f46\u5927\u90e8\u5206\u5fae\u751f\u7269\u5bf9\u6211\u4eec\u800c\u8a00\u4ecd\u7136\u662f\u672a\u77e5\u7684\u3002\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u4eba\u4f53\u5fae\u751f\u7269\u7ec4\u9879\u76ee\u7684\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u786e\u5b9a\uff0c\u4ec5\u4eba\u4f53\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u5c31\u6709 100 \u4e07\u4ebf\u7ec6\u83cc\uff0c\u662f\u4eba\u4f53\u7ec6\u80de\u6570\u91cf\u7684 10 \u500d\u3002\u6b64\u5916\uff0c\u5b83\u8fd8\u542b\u6709\u5927\u7ea6 800 \u4e07\u4e2a\u86cb\u767d\u8d28\u7f16\u7801\u57fa\u56e0\uff0c\u662f\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7684 360 \u500d\u3002\u79d1\u5b66\u5bb6\u4eec\u5df2\u7ecf\u4e86\u89e3\u5230\uff0c\u8fd9\u4e9b\u7ec6\u83cc\u7ec4\u6210\u7684\u53d8\u5316\u2014\u2014\u751f\u6001\u7cfb\u7edf\u4e2d\u7684\u4e00\u79cd\u5e72\u6270\u2014\u2014\u53ef\u80fd\u4e0e\u4e00\u7cfb\u5217\u4eba\u7c7b\u75be\u75c5\u6709\u5173\uff0c\u5305\u62ec\u708e\u75c7\u6027\u80a0\u75c5\u3001\u54ee\u5598\u3001\u5173\u8282\u708e\u548c\u591a\u53d1\u6027\u786c\u5316\u75c7[35]\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      <\/section>\n
      \u56fe15\uff1a\u7ee7\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u4e4b\u540e\uff0c\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u57282007\u5e74\u542f\u52a8\u4e86\u4e00\u4e2a\u7c7b\u4f3c\u7684\u96c4\u5fc3\u52c3\u52c3\u7684\u8ba1\u5212\u2014\u2014\u4eba\u7c7b\u5fae\u751f\u7269\u7ec4\u8ba1\u5212\uff08Human Microbiome Project\uff0cHMP\uff09\uff0chttps:\/\/www.hmpdacc.org\/\u3002<\/span><\/strong><\/span><\/section>\n

      <\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      Tackling the Microbiome<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/science.sciencemag.org\/content\/336\/6086\/1209<\/section>\n<\/blockquote>\n

      <\/section>\n
      \u610f\u5927\u5229\u7279\u4f26\u6258\u5927\u5b66\u7684\u4e00\u652f\u7814\u7a76\u56e2\u961f\u5c55\u5f00\u4e00\u9879\u8d85\u5927\u89c4\u6a21\u7814\u7a76\uff0c\u6837\u672c\u6db5\u76d6\u4e86\u4e0d\u540c\u5730\u7406\u4f4d\u7f6e\u3001\u5e74\u9f84\u548c\u751f\u6d3b\u65b9\u5f0f\u7684\u4eba\u7fa4\u4ee5\u53ca\u4eba\u4f53\u7684\u4e0d\u540c\u90e8\u4f4d\u3002\u4ed6\u4eec\u5229\u7528\u5355\u6837\u672c\u5b8f\u57fa\u56e0\u7ec4\u7ec4\u88c5\uff0c\u6784\u5efa\u51fa\u8d85\u8fc7 15 \u4e07\u4e2a\u4eba\u4f53\u5fae\u751f\u7269\u57fa\u56e0\u7ec4\uff0c\u5176\u4e2d 77% \u4ee5\u524d\u4ece\u672a\u88ab\u63cf\u8ff0\u8fc7\uff0c\u786e\u5b9a\u4e86\u4e00\u4e9b\u666e\u904d\u5b58\u5728\u3001\u4f46\u4ee5\u524d\u672a\u88ab\u53d1\u73b0\u7684\u5fae\u751f\u7269\u7c7b\u7fa4[36]\u3002<\/span><\/section>\n

      <\/span><\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      Extensive Unexplored Human Microbiome Diversity Revealed by Over 150,000 Genomes from Metagenomes Spanning Age, Geography, and Lifestyle<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/doi.org\/10.1016\/j.cell.2019.01.001<\/section>\n<\/blockquote>\n
       <\/span><\/section>\n

      <\/span><\/section>\n
      \n
      \n
      \n
      \n
      <\/p>\n

      \u6280\u672f\u4e0e\u5de5\u5177<\/strong><\/span><\/p>\n

      <\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

       <\/span>
      <\/section>\n
      \u4f5c\u4e3a ICGC\/TCGA \u5168\u57fa\u56e0\u7ec4\u6cdb\u764c\u5206\u6790\uff08PCAWG\uff09\u8054\u76df\u7684\u4e00\u90e8\u5206\uff0c\u4f5c\u8005\u8bad\u7ec3\u4e86\u4e00\u4e2a\u6df1\u5ea6\u5b66\u4e60\u5206\u7c7b\u5668\uff0c\u4ee5\u57fa\u4e8e\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff08WGS\uff09\u4e2d\u68c0\u6d4b\u5230\u7684\u4ee3\u8868 PCAWG \u8054\u76df\u4ea7\u751f\u7684 24 \u79cd\u5e38\u89c1\u764c\u75c7\u7c7b\u578b\u7684 2606 \u79cd\u80bf\u7624\u7684\u4f53\u7ec6\u80de\u65c5\u5ba2\u7a81\u53d8\u6a21\u5f0f\u6765\u9884\u6d4b\u764c\u75c7\u7c7b\u578b\u3002\u5206\u7c7b\u5668\u5728\u5207\u9664\u80bf\u7624\u6837\u672c\u4e0a\u7684\u51c6\u786e\u7387\u5206\u522b\u4e3a 91%\uff0c\u5728\u72ec\u7acb\u539f\u53d1\u548c\u8f6c\u79fb\u6837\u672c\u4e0a\u7684\u51c6\u786e\u7387\u5206\u522b\u4e3a 88% \u548c 83%\uff0c\u5927\u7ea6\u662f\u8bad\u7ec3\u8fc7\u7684\u75c5\u7406\u5b66\u5bb6\u5728\u4e0d\u4e86\u89e3\u539f\u53d1\u6837\u672c\u7684\u60c5\u51b5\u4e0b\u5bf9\u8f6c\u79fb\u80bf\u7624\u7684\u51c6\u786e\u7387\u7684\u4e24\u500d[37]\u3002<\/span><\/section>\n

      <\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/www.nature.com\/articles\/s41467-019-13825-8<\/section>\n<\/blockquote>\n

      <\/section>\n
      \u7406\u89e3\u590d\u6742\u7684\u751f\u7269\u7cfb\u7edf\u9700\u8981\u8f6f\u4ef6\u5de5\u5177\u7684\u5e7f\u6cdb\u652f\u6301\u3002\u7cfb\u7edf\u751f\u7269\u5b66\u8ba1\u7b97\u5de5\u4f5c\u6d41\u7a0b\u7684\u6bcf\u4e00\u6b65\u90fd\u9700\u8981\u8fd9\u4e9b\u5de5\u5177\uff0c\u901a\u5e38\u5305\u62ec\u6570\u636e\u5904\u7406\u3001\u7f51\u7edc\u63a8\u7406\u3001\u6df1\u5ea6\u7b5b\u9009\u3001\u52a8\u6001\u6a21\u62df\u548c\u6a21\u578b\u5206\u6790\u3002\u6b64\u5916\uff0c\u73b0\u5728\u6b63\u5728\u52aa\u529b\u5f00\u53d1\u96c6\u6210\u7684\u8f6f\u4ef6\u5e73\u53f0\uff0c\u4ee5\u4fbf\u5728\u5de5\u4f5c\u6d41\u7a0b\u7684\u4e0d\u540c\u9636\u6bb5\u4ee5\u53ca\u7531\u4e0d\u540c\u7684\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u7684\u5de5\u5177\u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u4e00\u8d77\u4f7f\u7528\u3002\u8fd9\u7bc7\u7efc\u8ff0\u63cf\u8ff0\u4e86\u5728\u7cfb\u7edf\u751f\u7269\u5b66\u7814\u7a76\u7684\u4e0d\u540c\u9636\u6bb5\u6240\u9700\u8981\u7684\u8f6f\u4ef6\u5de5\u5177\u7684\u7c7b\u578b\uff0c\u4ee5\u53ca\u76ee\u524d\u53ef\u4f9b\u7cfb\u7edf\u751f\u7269\u5b66\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u7684\u9009\u62e9[38]\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \n
      \u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
      Software for systems biology: from tools to integrated platforms<\/span><\/section>\n
      \u8bba\u6587\u5730\u5740\uff1a<\/section>\n
      https:\/\/doi.org\/10.1038\/nrg3096<\/section>\n<\/blockquote>\n

      \n


      <\/p>\n


      <\/span><\/p>\n<\/h3>\n

      \n
      \n
      \n
      \u53c2\u8003\u6587\u732e\uff1a<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n
      \n