{"id":20903,"date":"2020-08-30T21:07:02","date_gmt":"2020-08-30T13:07:02","guid":{"rendered":"https:\/\/swarma.org\/?p=20903"},"modified":"2020-08-30T21:07:02","modified_gmt":"2020-08-30T13:07:02","slug":"nature-%e7%89%a9%e7%90%86%ef%bc%9a%e8%a7%84%e6%a8%a1%e6%b3%95%e5%88%99%e5%88%b6%e7%ba%a6%e8%82%bf%e7%98%a4%e7%94%9f%e9%95%bf","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=20903","title":{"rendered":"Nature \u7269\u7406\uff1a\u89c4\u6a21\u6cd5\u5219\u5236\u7ea6\u80bf\u7624\u751f\u957f"},"content":{"rendered":"
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Universal scaling laws rule explosive growth in human cancers<\/section>\n
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https:\/\/www.nature.com\/articles\/s41567-020-0978-6<\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n
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1. \u514b\u83b1\u4f2f\u6cd5\u5219\uff1a<\/strong><\/span><\/p>\n

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\u5723\u5854\u83f2\u7814\u7a76\u6240\u524d\u6240\u957fGeoffrey West\u5728\u79d1\u666e\u4e66\u300a\u89c4\u6a21\u300b\u4e2d\uff0c\u63ed\u793a\u4e86\u89c4\u6a21\u6cd5\u5219\uff08scaling law\uff09\uff0c\u8fd9\u4e00\u5728\u4eba\u7c7b\u793e\u4f1a\u53ca\u81ea\u7136\u754c\u4e2d\uff0c\u4f46\u51e1\u662f\u7531\u5927\u91cf\u76f8\u4e92\u4f5c\u7528\u7684\u4e2a\u4f53\u7ec4\u6210\u7684\u590d\u6742\u7cfb\u7edf\uff0c\u90fd\u666e\u904d\u9002\u7528\u7684\u4e00\u822c\u6027\u89c4\u5f8b\u3002
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2. \u80bf\u7624\u7ec4\u7ec7\u5448\u73b0\u8d85\u7ebf\u6027\u589e\u957f<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0d\u540c\u4e8e\u514b\u83b1\u4f2f\u6cd5\u5219\u63cf\u8ff0\u7684\u4e9a\u7ebf\u6027\u589e\u957f\uff0c\u8be5\u7814\u7a76\u5f97\u51fa\u7684\u7b2c\u4e00\u4e2a\u7ed3\u8bba\u662f\uff1a\u764c\u75c7\u7ec4\u7ec7\u5e76\u4e0d\u9075\u5faa3\/4\u6cd5\u5219\uff0c\u800c\u662f\u5448\u73b0\u8d85\u7ebf\u6027\u589e\u957f\uff0c\u80bf\u7624\u7684\u4f53\u79ef\u589e\u52a0\u4e00\u500d\uff0c\u5176\u65b0\u9648\u4ee3\u8c22\u901f\u5ea6\u7684\u589e\u52a0\u8981\u8d85\u8fc7\u4e00\u500d\u3002\u8fd9\u4e8e\u5f53\u524d\u764c\u75c7\u4e3b\u6d41\u7814\u7a76\u4e2d\u5047\u8bbe\u7684\u7ebf\u6027\u6307\u6570\u589e\u957f\u4e0d\u540c\uff0c\u8fd9\u610f\u5473\u7740\u5f53\u524d\u7684\u764c\u75c7\u7814\u7a76\u8005\u4f4e\u4f30\u4e86\u6076\u6027\u80bf\u7624\u7ec4\u7ec7\u7684\u751f\u957f\u901f\u5ea6\u3002<\/span><\/p>\n

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\u56fe2\uff1a\u5206\u522b\u4e3a\u4e73\u817a\u764c\u3001\u5934\u9888\u90e8\u764c\u75c7\u3001\u9ed1\u8272\u7d20\u80f6\u8d28\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u80f0\u817a\u764c\u5207\u9762\u6d3b\u52a8\u91cf\u4e4b\u548c\uff08\u7eb5\u8f74\uff1atotal lesion activity \uff09\u4e0e\u4ee3\u8c22\u80bf\u7624\u4f53\u79ef\uff08\u6a2a\u8f74\uff1ametabolic tumour volume\uff09\u7684\u5173\u7cfb\uff08\u70b9\u51fb\u67e5\u770b\u5927\u56fe\uff09<\/span><\/p>\n

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\u6ce8:\u4e0a\u56fe\u4e2d\uff0c\u5bf9\u672a\u7ecf\u8fc7\u836f\u7269\u6cbb\u7597\u7684\u4eba\u4f53\u80bf\u7624\u7ec4\u7ec7\u8fdb\u884c\u5728\u4f53PET-CT\u9010\u5c42\u626b\u63cf\uff0c\u7531\u4e8ePET-ct\u91c7\u7528\u540c\u4f4d\u7d20\u6807\u8bb0\u768418f- \u6c1f\u8131\u6c27\u8461\u8404\u7cd6\uff0818F-PDG\uff09\u793a\u8e2a\u6210\u50cf\uff0c\u80fd\u591f\u901a\u8fc7\u8461\u8404\u7cd6\u7684\u6d88\u8017\u76f4\u63a5\u53cd\u5e94\u626b\u63cf\u622a\u9762\u7684\u4ee3\u8c22\u6c34\u5e73\uff0c\u4ece\u800c\u4f30\u7b97\u80bf\u7624\u7ec4\u7ec7\u7684\u603b\u4ee3\u8c22\u7a0b\u5ea6\u3002\u56fe\u4e2d\u6bcf\u4e2a\u70b9\u4ee3\u8868\u8be5\u7c7b\u80bf\u7624\u7684\u4e00\u4e2a\u6837\u672c\u3002\u4eba\u4f53\u4e0a\u7684\u70b9\u6807\u6ce8\u4e86\u6bcf\u7c7b\u80bf\u7624\u51fa\u73b0\u5728\u4eba\u4f53\u4e2d\u7684\u4f4d\u7f6e\u3002<\/span><\/em><\/span><\/p>\n


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3. \u4e3a\u4f55\u80bf\u7624\u80fd\u7a81\u7834\u514b\u83b1\u4f2f\u6cd5\u5219\uff1f<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h1>\n

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\u4fb5\u6da6\u6027\u5b9e\u4f53\u7ec4\u7ec7\u7624\u5e38\u65e0\u5b9a\u578b\uff0c\u5373\u5448\u73b0\u4e0d\u89c4\u5219\u7684\u5f62\u72b6\uff0c\u800c\u4e14\u6ca1\u6709\u7279\u5b9a\u7684\u89c4\u5f8b\u3002\u800c\u8fd9\u6b63\u662f\u80bf\u7624\u5f97\u4ee5\u7a81\u7834\u514b\u83b1\u4f2f\u6cd5\u5219\u7684\u539f\u56e0\u3002\u56fe3\u4e2d\uff0c\u57fa\u4e8e\u8ba1\u7b97\u673a\u6a21\u62df\u7684\u80bf\u7624\u7ec4\u7ec7\uff0c\u5448\u73b0\u7403\u5f62\u751f\u957f\uff08\u84dd\u7ebf\uff09\uff0c\u5176\u4f53\u79ef\u548c\u603b\u5207\u9762\u4ee3\u8c22\u91cf\u4e4b\u95f4\u7684\u5e42\u5f8b\u6307\u6570\u4e3a0.8\uff0c\u63a5\u8fd1\u514b\u83b1\u4f2f\u6cd5\u5219\u4e2d\u76840.75\uff0c\u800c\u771f\u5b9e\u7684\u80bf\u7624\u7ec4\u7ec7\u7684\u751f\u957f\uff08\u7ea2\u7ebf\uff09\u4e3a\u771f\u5b9e\u7684\u80bf\u7624\u7ec4\u7ec7\uff0c\u5176\u5e42\u5f8b\u6307\u6570\u4e3a1.14\uff0c\u4e3a\u8d85\u7ebf\u6027\u589e\u957f\u3002<\/span><\/p>\n


<\/section>\n

\u80bf\u7624\u5f02\u8d28\u6027\u662f\u6076\u6027\u80bf\u7624\u5730\u91cd\u8981\u7279\u5f81\u4e4b\u4e00\uff0c\u662f\u6307\u80bf\u7624\u7ec6\u80de\u7531\u4e8e\u57fa\u56e0\u7ec4\u7a33\u5b9a\u6027\u88ab\u7834\u574f\uff0c\u5176\u5728\u751f\u957f\u8fc7\u7a0b\u4e2d\u5404\u4e2a\u5b50\u4ee3\u7ec6\u80de\u4ea7\u751f\u5927\u91cf\u7684\u57fa\u56e0\u7a81\u53d8\u6216\u67d3\u8272\u4f53\u5f02\u5e38\uff0c\u8fdb\u800c\u80bf\u7624\u7ec6\u80de\u95f4\u7684\u57fa\u56e0\u578b\u548c\u7ec6\u80de\u7279\u6027\u51fa\u73b0\u4e86\u5de8\u5927\u7684\u5dee\u5f02\uff0c\u8fd9\u662f\u6076\u6027\u80bf\u7624\u53ef\u4ee5\u901a\u8fc7\u5916\u90e8\u538b\u529b\u548c\u5185\u90e8\u7ade\u4e89\u5feb\u901f\u8fdb\u5316\u7684\u9057\u4f20\u5b66\u57fa\u7840\u3002<\/span><\/p>\n


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\u56fe3a\u5c55\u793a\u4e86\u80bf\u7624\u7ec4\u7ec7\u7684\u6f14\u5316\u52a8\u529b\u5b66\u6a21\u5f0f\u3002\u5728\u80bf\u7624\u7ec4\u7ec7\u7531\u5c0f\u589e\u5927\u7684\u8fc7\u7a0b\u4e2d\uff0c\u7531\u4e8e\u5f02\u8d28\u6027\u7684\u5b58\u5728\uff0c\u5176\u4e2d\u7684\u7ec6\u80de\u4f1a\u968f\u673a\u51fa\u73b0\u751f\u957f\u6216\u589e\u6b96\u66f4\u5feb\u7684\u9057\u4f20\u53d8\u5f02\uff08\u56fe3\u4e2d\u9634\u5f71\u7ec6\u80de\uff09\uff0c\u8fd9\u4e2a\u53d8\u5f02\u7ec6\u80de\u7684\u5b50\u4ee3\u589e\u957f\u663e\u8457\u5feb\u4e8e\u5176\u5b83\u7ec6\u80de\uff0c\u4ece\u800c\u51fa\u73b0\u5feb\u901f\u589e\u5927\u7684\u4e9a\u56e2\u5757\u3002<\/span><\/p>\n


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\u5feb\u901f\u589e\u957f\u7684\u4e9a\u56e2\u5757\u4e2d\uff0c\u53c8\u56e0\u4e3a\u67d0\u4e2a\u7ec6\u80de\u7684\u968f\u673a\u53d8\u5f02\u4ea7\u751f\u4e86\u751f\u957f\u6216\u589e\u6b96\u901f\u7387\u66f4\u5feb\u7684\u68d5\u8272\u7ec6\u80de\u3002\u6700\u7ec8\u603b\u662f\u589e\u6b96\u66f4\u5feb\u7684\u7ec6\u80de\u56e2\u53ca\u5176\u5b50\u4ee3\u5728\u5185\u90e8\u7ade\u4e89\u4e2d\u88ab\u7b5b\u9009\u51fa\u6765\uff0c\u4ece\u800c\u62c9\u9ad8\u4e86\u6574\u4e2a\u80bf\u7624\u7ec4\u7ec7\u7684\u589e\u957f\u901f\u7387\u3002<\/span><\/p>\n


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\u56fe3c\u5c06\u540c\u4e00\u5757\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u7ec6\u80de\u6309\u7167\u751f\u957f\u901f\u5ea6\u5feb\u6162\uff0c\u533a\u5206\u51fa\u4e864\u4e2a\u4e9a\u7cfb\u3002\u5f53\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u67d0\u4e00\u7cfb\u764c\u7ec6\u80de\u7531\u4e8e\u80fd\u91cf\u9650\u5236\u53d8\u4e3a\u4e9a\u7ebf\u6027\u589e\u957f\u540e\uff0c\u80bf\u7624\u4e2d\u4f1a\u4ea7\u751f\u51fa\u7684\u4e0d\u4f9d\u8d56\u4e8e\u539f\u6709\u80fd\u91cf\u9014\u5f84\u7684\u65b0\u4e9a\u7cfb\uff0c\u4ece\u800c\u7ee7\u7eed\u7ef4\u6301\u8d85\u7ebf\u6027\u589e\u957f\u3002\u56e0\u6b64\uff0c\u53ea\u8981\u80bf\u7624\u7ec4\u7ec7\u4e2d\u4ecd\u7136\u6709\u4e00\u7c7b\u4ecd\u7136\u5904\u5728\u8d85\u7ebf\u6027\u589e\u957f\u7684\u4e9a\u578b\uff0c\u5176\u6574\u4f53\u5c31\u80fd\u591f\u4fdd\u6301\u8d85\u7ebf\u6027\u589e\u957f\u3002<\/span><\/p>\n


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\u6b63\u56e0\u4e3a\u80bf\u7624\u7ec4\u7ec7\u5185\u90e8\u5176\u5b9e\u5305\u542b\u5f02\u8d28\u5316\u7684\u4e9a\u578b\uff0c\u56e0\u6b64\u764c\u75c7\u624d\u5982\u6b64\u96be\u4ee5\u88ab\u6839\u6cbb\u3002\u800c\u53d8\u5f02\u4f4d\u7f6e\u7684\u968f\u673a\u51fa\u73b0\uff0c\u4f7f\u5f97\u80bf\u7624\u7ec4\u7ec7\u7684\u751f\u957f\u6beb\u65e0\u89c4\u5f8b\uff0c\u4ece\u800c\u4f53\u73b0\u4e86\u80bf\u7624\u7ec4\u7ec7\u5448\u73b0\u7684\u4e09\u7ef4\u5f62\u72b6\u4e0d\u89c4\u5219\u3002<\/span><\/p>\n


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4. \u5e42\u5f8b\u6307\u6570\uff1a<\/strong><\/span><\/p>\n

\u9884\u6d4b\u764c\u75c7\u60a3\u8005\u751f\u5b58\u7387<\/strong><\/span><\/p>\n

<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

 <\/span><\/p>\n

\u60a3\u4e0a\u540c\u4e00\u79cd\u764c\u75c7\u7684\u60a3\u8005\uff0c\u4e3a\u4f55\u6709\u7684\u80fd\u591f\u575a\u6301\u6d3b\u5f88\u4e45\uff0c\u6709\u7684\u5374\u4e0d\u884c\u3002\u533b\u5b66\u4e0a\u5bf9\u6b64\u7684\u7edf\u8ba1\u88ab\u79f0\u4e3aKaplan\u2013Meier\u751f\u5b58\u7387\u66f2\u7ebf\uff0c\u63cf\u8ff0\u4e86\u8be5\u7c7b\u764c\u75c7\u60a3\u8005\u5728\u4e00\u5b9a\u65f6\u95f4\u5185\u751f\u5b58\u7387\u968f\u65f6\u95f4\u53d8\u5316\u7684\u60c5\u51b5\u3002<\/span><\/p>\n


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\u56fe4\uff1a\u9ed1\u8272\u7d20\u80f6\u8d28\u764c\u3001\u5934\u9888\u90e8\u764c\u3001\u4e09\u671f\u53ca\u56db\u671f\u80ba\u5c0f\u7ec6\u80de\u764c\u4e0e\u4e73\u817a\u764c\u4e0d\u540c\u5e42\u5f8b\u6307\u6570\u7684\u4e94\u5e74\u751f\u5b58\u7387<\/span><\/section>\n


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\u56fe4\u4e2d\u6bcf\u5e45\u56fe\u4e2d\u6a2a\u8f74\u662f\u786e\u8bca\u764c\u75c7\u4e4b\u540e\u7684\u6708\u4efd\uff0c\u7eb5\u8f74\u662f\u60a3\u8005\u7684\u751f\u5b58\u7387\u3002\u6839\u636e\u5bf9\u80bf\u7624\u7ec4\u7ec7\u751f\u957f\u8fc7\u7a0b\u7684\u5e42\u5f8b\u6307\u6570\uff0c\u5c06\u5927\u4e8e5\/4\uff08>1.25\uff09\u7684\u89c4\u5b9a\u4e3a\u84dd\u7ebf\uff0c\u5c0f\u4e8e\u7684\u5b9a\u4e3a\u7ea2\u7ebf\u3002\u53ef\u4ee5\u770b\u51fa\uff0c\u901a\u8fc7\u5e42\u5f8b\u6307\u6570\uff0c\u80fd\u591f\u6784\u5efa\u5206\u7c7b\u6a21\u578b\uff0c\u5bf9\u764c\u75c7\u60a3\u8005\u6309\u751f\u5b58\u6982\u7387\u8fdb\u884c\u5206\u7c7b\u3002<\/span><\/p>\n


<\/p>\n

\u56fe4\u4e2d\u7684C-index\u662f\u8861\u91cf\u764c\u75c7\u5206\u7c7b\u6a21\u578b\u6548\u679c\u7684\u5e38\u7528\u6307\u6807\uff0c\u503c\u8d8a\u9ad8\uff0c\u8bf4\u660e\u8be5\u6a21\u578b\u7684\u5206\u7c7b\u8d8a\u51c6\u786e\u3002\u800c\u6839\u636e\u524d\u6587\u63d0\u5230\u7684\uff0c\u4e0d\u540c\u7c7b\u578b\u80bf\u7624\u6240\u5c55\u73b0\u51fa\u7684\u4e0d\u540c\u201c\u5e42\u5f8b\u6307\u6570\u201d\uff0c\u4f8b\u5982\u80ba\u5c0f\u7ec6\u80de\u764c\u548c\u9ed1\u8272\u7d20\u80f6\u8d28\u764c\u5206\u522b\u4e3a1.259\u548c1.211\u3002\u56fe4\u6307\u51fa\uff0c\u5e42\u5f8b\u6307\u6570\u80fd\u591f\u4f5c\u4e3a\u4e00\u4e2a\u901a\u7528\u6307\u6807\uff0c\u7528\u5728\u591a\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u764c\u75c7\u75c5\u60a3\u7684\u7597\u6548\u9884\u6d4b\u4e0a\u3002<\/span><\/p>\n


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\u4e3a\u4ec0\u4e48\u4f1a\u6709\u7684\u764c\u75c7\u9884\u6d4b\u6a21\u578b\u533a\u5206\u5ea6\u66f4\u5927\u4e86\uff1f\u8054\u7cfb\u524d\u6587\u63d0\u5230\u7684\uff0c\u8fd9\u4e24\u79cd\u764c\u75c7\u5bf9\u4e8e\u7684\u80bf\u7624\u7ec4\u7ec7\u7684\u5e42\u5f8b\u6307\u6570\u5206\u522b\u4e3a1.249\u548c1.211\uff0c\u63a5\u8fd11.25\u7684\u5206\u7c7b\u9608\u503c\uff0c\u7531\u6b64\u53ef\u4ee5\u89e3\u91ca\u4e3a\u4f55\u76f8\u5bf9\u6765\u8bf4\uff0c\u8fd9\u4e24\u79cd\u764c\u75c7\u7684\u5206\u7c7b\u6548\u679c\u8f83\u5dee\u3002\u800c\u5206\u7c7b\u8f83\u597d\u7684\u5934\u9888\u90e8\u764c\u548c\u4e73\u817a\u764c\u5206\u522b\u4e3a1.188\u548c1.182\uff0c\u56e0\u6b64\u5206\u7c7b\u66f4\u51c6\u3002<\/span><\/p>\n

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5. \u4e3a\u4f55\u6211\u4eec\u8fd8\u6ca1\u6709\u60a3\u4e0a\u764c\u75c7\uff1f<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h1>\n

 <\/span><\/section>\n

\u5c31\u5728\u6b64\u523b\uff0c\u6211\u4eec\u7684\u8eab\u4f53\u4e2d\u5c31\u5b58\u5728\u7740\u764c\u7ec6\u80de\uff0c\u4f46\u5b83\u4eec\u90fd\u53ca\u65f6\u88ab\u514d\u75ab\u7cfb\u7edf\u6740\u6b7b\u4e86\u3002\u53ea\u6709\u5f53\u80bf\u7624\u7ec4\u7ec7\u53d8\u5f97\u8db3\u591f\u5927\u4e4b\u540e\uff0c\u90a3\u4e9b\u88ab\u514d\u75ab\u7cfb\u7edf\u6740\u6389\u7684\u764c\u7ec6\u80de\u624d\u4f1a\u76f8\u6bd4\u80bf\u7624\u7ec4\u7ec7\u6765\u8bf4\uff0c\u53d8\u5f97\u4e5d\u725b\u4e00\u6bdb\u800c\u65e0\u5173\u75db\u75d2\uff0c\u4ece\u800c\u4f7f\u5f97\u764c\u75c7\u53d8\u5f97\u4e0d\u53ef\u907f\u514d\u3002<\/span><\/p>\n


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\u5f53\u524d\u7684\u4e3b\u6d41\u80bf\u7624\u6a21\u578b\uff0c\u5047\u8bbe\u80bf\u7624\u7684\u751f\u957f\u662f\u7ebf\u6027\u589e\u957f\u7684\uff0c\u5373\u6307\u6570\u4e3a1\u3002\u800c\u672c\u7814\u7a76\u6307\u51fa\u5927\u90e8\u5206\u80bf\u7624\u90fd\u662f\u8d85\u7ebf\u6027\u751f\u957f\u7684\uff0c\u56e0\u6b64\u5f53\u524d\u6a21\u578b\u53ef\u80fd\u4f4e\u4f30\u4e86\u764c\u75c7\u7684\u751f\u957f\u901f\u5ea6\u3002<\/span><\/p>\n


<\/p>\n

\u90a3\u4e9b\u771f\u6b63\u4f7f\u4eba\u60a3\u4e0a\u764c\u75c7\u7684\u80bf\u7624\u7ec4\u7ec7\uff0c\u5728\u53d8\u5f97\u80fd\u591f\u901a\u8fc7\u5f71\u50cf\u624b\u6bb5\u88ab\u53d1\u73b0\u4e4b\u524d\uff0c\u5176\u751f\u957f\u4ecd\u7136\u5448\u73b0\u8d85\u7ebf\u6027\u589e\u957f\u3002\u80bf\u7624\u7ec4\u7ec7\u751f\u957f\u521d\u671f\u7684\u8fdb\u5316\u52a8\u529b\u5b66\uff0c\u503c\u5f97\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u3002\u901a\u8fc7\u751f\u6001\u5b66\u7684\u6a21\u578b\uff0c\u641e\u6e05\u695a\u662f\u4ec0\u4e48\u6837\u7684\u73af\u5883\u56e0\u7d20\uff0c\u8ba9\u80bf\u7624\u7ec4\u7ec7\u7684\u7fa4\u4f53\u884c\u4e3a\u51fa\u73b0\u8f6c\u53d8\uff0c\u8fdb\u800c\u53ca\u65e9\u8bca\u65ad\uff0c\u5e76\u901a\u8fc7\u963b\u6b62\u4fc3\u6210\u8f6c\u53d8\u7684\u73af\u5883\u56e0\u7d20\uff0c\u627e\u5230\u764c\u75c7\u7684\u6f5c\u5728\u6cbb\u7597\u65b9\u6cd5\u3002<\/span><\/p>\n


<\/p>\n

\u5728\u836f\u7269\u4f5c\u7528\u4e0b\uff0c\u80bf\u7624\u7ec4\u7ec7\u4e0d\u540c\u5c40\u90e8\u7684\u751f\u957f\u901f\u7387\u4e0d\u540c\uff0c\u5982\u679c\u80fd\u591f\u603b\u662f\u5728\u8d85\u7ebf\u6027\u589e\u957f\u7684\u90e8\u5206\u51fa\u73b0\u524d\uff0c\u5c31\u5c06\u5176\u627c\u6740\u4e8e\u840c\u82bd\u72b6\u6001\uff0c\u5c31\u53ef\u80fd\u6291\u5236\u80bf\u7624\u7ec4\u7ec7\u6574\u4f53\u7684\u751f\u957f\u3002\u56e0\u6b64\uff0c\u5f02\u8d28\u6027\u7684\u80bf\u7624\u7ec4\u7ec7\u4e4b\u95f4\uff0c\u4ee5\u53ca\u80bf\u7624\u7ec4\u7ec7\u4e0e\u836f\u7269\u7684\u5982\u4f55\u4e92\u4f5c\uff0c\u8fd9\u662f\u8fd1\u5e74\u6765\u7684\u4e00\u4e2a\u7814\u7a76\u70ed\u70b9\u3002<\/span><\/p>\n


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6. \u514b\u83b1\u4f2f\u6cd5\u5219\u5728\u751f\u7269\u754c\u7684\u5c40\u9650<\/strong><\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h1>\n


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2020\u5e747\u6708\u7684 PNAS <\/em>\u4e2d\uff0c\u5173\u4e8e\u751f\u7269\u4f53\u7684\u89c4\u6a21\u6cd5\u5219\uff0c\u6709\u4e00\u7bc7\u6700\u65b0\u7814\u7a76\u6210\u679c\uff0c\u901a\u8fc7\u5c06\u771f\u6838\u751f\u7269\u7edf\u4e00\u7814\u7a76\uff0c\u800c\u4e0d\u662f\u50cf\u4e4b\u524d\u90a3\u6837\uff0c\u53ea\u5173\u6ce8\u54fa\u4e73\u52a8\u7269\u3001\u9e1f\u7c7b\u8fd9\u6837\u7684\u9ad8\u7b49\u751f\u7269\uff0c\u53d1\u73b0\u514b\u83b1\u4f2f\u6cd5\u5219\u5176\u5b9e\u5e76\u4e0d\u662f\u90a3\u4e48\u901a\u7528\u3002<\/span><\/p>\n


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\u56fe5\u4e2d\u6bcf\u4e00\u70b9\u4ee3\u8868\u4e00\u4e2a\u7269\u79cd\uff0c\u7ea2\u8272\u7684\u4ee3\u8868\u54fa\u4e73\u52a8\u7269\uff0c\u7eff\u8272\u7684\u4e3a\u690d\u7269\uff0c\u84dd\u8272\u4e3a\u53d8\u6e29\u52a8\u7269\uff0c\u9ec4\u8272\u4e3a\u539f\u751f\u751f\u7269\uff0c\u4f8b\u5982\u6c34\u85fb\u8fd9\u6837\u6700\u4f4e\u7b49\u7684\u771f\u6838\u751f\u7269\uff0c\u7531\u4e8e\u5176\u4e3a\u5355\u7ec6\u80de\u751f\u7269\uff0c\u56e0\u6b64\u5176\u5927\u5c0f\u4e3a\u5176\u7fa4\u843d\u5927\u5c0f\uff0c\u800c\u4e0d\u662f\u5982\u524d\u4e09\u7c7b\uff0c\u662f\u5bf9\u5e94\u4e2a\u4f53\u7684\u5927\u5c0f\u3002\u800c\u7070\u8272\u4ee3\u8868\u4e0d\u7b26\u5408\u771f\u6838\u751f\u7269\u7684\u7ec6\u83cc\u3002<\/span><\/p>\n

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\u7531\u4e8e\u4e0d\u8bba\u662f\u764c\u7ec6\u80de\u8fd8\u662f\u7ec6\u83cc\uff0c\u5176\u751f\u957f\u90fd\u662f\u9075\u7167\u89c4\u6a21\u6cd5\u5219\u7684\uff0c\u6b63\u662f\u8fd9\u4e00\u76f8\u4f3c\u6027\uff0c\u4fc3\u4f7f\u7b14\u8005\u731c\u60f3\uff0c\u7ed3\u5408\u83cc\u7fa4\u5177\u6709\u7684\u514d\u75ab\u548c\u5185\u5206\u6ccc\u8c03\u8282\u673a\u4f53\u529f\u80fd\uff0c\u901a\u8fc7\u6539\u53d8\u83cc\u7fa4\u7ec4\u6210\uff0c\u6d3b\u83cc\u836f\u7269\u80fd\u591f\u6301\u7eed\u6027\u5730\u53d1\u6325\u5f71\u54cd\uff0c\u56e0\u4e3a\u5176\u751f\u957f\u540c\u6837\u5448\u73b0\u89c4\u6a21\u6cd5\u5219\u3002<\/span><\/p>\n


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7. \u4eba\u7c7b\u662f\u5730\u7403\u7684\u764c\u7ec6\u80de\u5417\uff1f<\/strong><\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h1>\n


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<\/p>\n

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\u75ab\u60c5\u3001\u8757\u707e\u3001\u6781\u7aef\u5929\u6c14\u2026\u20262020\u5e74\u7684\u5947\u5e7b\u8ba9\u8d8a\u6765\u8d8a\u591a\u7684\u4eba\u6000\u7591\uff0c\u6211\u4eec\u7a76\u7adf\u662f\u4e0d\u662f\u5730\u7403\u7684\u764c\u7ec6\u80de\u3002\u5373\u5c06\u5230\u6765\u7684\u5947\u70b9<\/a>\uff0c\u7a76\u7adf\u5bf9\u6211\u4eec\u610f\u5473\u7740\u6c38\u751f\u8fd8\u662f\u6bc1\u706d\u3002\u5bf9\u4e8e\u8be5\u95ee\u9898\uff0c\u4ece\u590d\u6742\u7cfb\u7edf\u7684\u89c6\u89d2\u6765\u770b\uff0c\u53d6\u51b3\u4e8e\u6211\u4eec\u7684\u7ecf\u6d4e\u7cfb\u7edf\u662f\u5f00\u653e\u8fd8\u662f\u5c01\u95ed\u7cfb\u7edf\u3002<\/span><\/p>\n


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\u5982\u679c\u662f\u5c01\u95ed\u7cfb\u7edf\uff0c\u90a3\u4e48\u968f\u7740\u71b5\u589e\uff0c\u6211\u4eec\u751f\u6d3b\u7684\u73af\u5883\u4f1a\u53d8\u5f97\u8d8a\u6765\u8d8a\u65e0\u5e8f\u3002\u5bf9\u4e8e\u764c\u7ec6\u80de\uff0c\u5176\u53ea\u662f\u4e0d\u65ad\u5730\u4ece\u8eab\u4f53\u83b7\u5f97\u80fd\u91cf\uff0c\u56e0\u6b64\u53ef\u4ee5\u5c06\u5176\u89c6\u4e3a\u5c01\u95ed\u7cfb\u7edf\u3002\u5c01\u95ed\u7cfb\u7edf\u4e0b\u7684\u751f\u957f\uff0c\u5c31\u4f1a\u51fa\u73b0\u5982\u540c\u6076\u6027\u80bf\u7624\u5448\u73b0\u7684\u4e0d\u89c4\u5219\u5f62\u72b6\uff0c\u6291\u6216\u662f\u57ce\u5e02\u5982\u540c\u6251\u5927\u997c\u90a3\u6837\u5730\u4efb\u610f\u751f\u957f\u3002<\/span><\/p>\n


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\u7136\u800c\u5728\u5f00\u653e\u7cfb\u7edf\u4e2d\uff0c\u4e0e\u5916\u754c\u7684\u4fe1\u606f\u548c\u80fd\u91cf\u4ea4\u6362\uff0c\u4f1a\u4fc3\u6210\u7cfb\u7edf\u5185\u90e8\u4ea7\u751f\u79e9\u5e8f\uff0c\u4ece\u800c\u5728\u5c40\u90e8\u51fa\u73b0\u71b5\u7684\u964d\u4f4e\u3002\u5c31\u50cf\u6b63\u5e38\u7684\u7ec4\u7ec7\u5728\u751f\u957f\u5230\u4e00\u5b9a\u9636\u6bb5\u540e\uff0c\u5c31\u4f1a\u51cf\u901f\u3002\u5f00\u653e\u7cfb\u7edf\u4e0b\u7684\u57ce\u5e02\uff0c\u4e0d\u4f1a\u65e0\u9650\u5ea6\u5730\u53d8\u5f97\u66f4\u5927\u66f4\u5feb\uff0c\u800c\u662f\u5728\u5176\u5185\u90e8\u4ea7\u751f\u51fa\u8d8a\u6765\u8d8a\u7cbe\u7ec6\u7684\u7ed3\u6784\u548c\u89c4\u5f8b\u3002<\/span><\/p>\n


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\u7136\u800c\u5f53\u4e0b\u6211\u4eec\u5728\u521b\u9020\u8d22\u5bcc\u7684\u540c\u65f6\uff0c\u7531\u4e8e\u6211\u4eec\u5bf9\u8d22\u5bcc\u7684\u5b9a\u4e49\uff0c\u6ca1\u6709\u5305\u542b\u8d22\u5bcc\u521b\u9020\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u7684\u526f\u4ea7\u54c1\uff0c\u8fd9\u4f7f\u5f97\u6211\u4eec\u7684\u7ecf\u6d4e\u4f53\u7cfb\uff0c\u8d8a\u6765\u8d8a\u50cf\u4e00\u4e2a\u5c01\u95ed\u7cfb\u7edf\u3002\u8fd9\u624d\u662f\u4e3a\u4f55\u4f1a\u51fa\u73b02020\u5e74\u8bf8\u591a\u4e71\u8c61\u7684\u6839\u672c\u539f\u56e0\u3002<\/span><\/p>\n


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\u800c\u8981\u60f3\u6539\u53d8\u8fd9\u4e00\u5207\uff0c\u9700\u8981\u6211\u4eec\u4ece\u6839\u672c\u4e0a\uff0c\u6539\u53d8\u5bf9\u4f55\u4e3a\u8d22\u5bcc\u7684\u5b9a\u4e49\uff0c\u6211\u4eec\u9700\u8981\u5c06\u81ea\u7136\u754c\u514d\u8d39\u63d0\u4f9b\u7684\u670d\u52a1\uff0c\u770b\u6210\u662f\u4e00\u79cd\u9700\u8981\u8ba1\u4ef7\u7684\u670d\u52a1\uff0c\u9700\u8981\u5c06\u6211\u4eec\u6392\u51fa\u7684\u5e9f\u7269\uff0c\u6309\u7167\u5176\u6d88\u89e3\u7684\u79e9\u5e8f\u8bb0\u4e3a\u6210\u672c\u3002<\/span><\/p>\n


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\u5f53\u6211\u4eec\u4e0d\u65ad\u5730\u589e\u52a0\u5bf9\u81ea\u7136\u7684\u64cd\u63a7\uff0c\u6211\u4eec\u9700\u8981\u4e0d\u65ad\u6269\u5c55\u5bf9\u8d22\u5bcc\u7684\u5b9a\u4e49\u8303\u56f4\uff0c\u8ba9\u52a0\u901f\u4ea7\u751f\u7684\u589e\u91cf\uff0c\u88ab\u7f6e\u4e8e\u5f00\u653e\u7cfb\u7edf\u7684\u89c6\u89d2\u4e4b\u4e0b\uff0c\u552f\u6709\u5982\u6b64\u624d\u80fd\u8ba9\u6211\u4eec\u7684\u7ecf\u6d4e\u5faa\u73af\u53d8\u5f97\u8d8b\u5411\u5f00\u653e\u7cfb\u7edf\u3002<\/span><\/p>\n


<\/span><\/p>\n


<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/span><\/strong><\/p>\n

[1]https:\/\/www.pnas.org\/content\/116\/43\/21616#T1<\/span><\/p>\n

[2]https:\/\/zhuanlan.zhihu.com\/p\/89639095<\/span><\/p>\n

[3]https:\/\/science.sciencemag.org\/content\/368\/6494\/973<\/span><\/p>\n

[4]https:\/\/www.jbc.org\/content\/early\/2019\/04\/30\/jbc.RA119.008180<\/span><\/p>\n


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