{"id":21451,"date":"2020-10-26T19:14:27","date_gmt":"2020-10-26T11:14:27","guid":{"rendered":"https:\/\/swarma.org\/?p=21451"},"modified":"2020-10-26T19:14:27","modified_gmt":"2020-10-26T11:14:27","slug":"nature%e9%80%9a%e8%ae%af%ef%bc%9a%e5%9f%ba%e4%ba%8e%e5%85%88%e9%aa%8c%e7%9f%a5%e8%af%86%e7%9a%84%e7%bd%91%e7%bb%9c%e6%8e%a8%e6%96%ad","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=21451","title":{"rendered":"Nature\u901a\u8baf\uff1a\u57fa\u4e8e\u5148\u9a8c\u77e5\u8bc6\u7684\u7f51\u7edc\u63a8\u65ad"},"content":{"rendered":"
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\u5173\u8054\u7f51\u7edc\uff08correlation network\uff09\u5e38\u5e38\u88ab\u7528\u4e8e\u63d0\u53d6\u751f\u7269\u7ec4\u5b66\u4e2d\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4f46\u5176\u8fde\u8fb9<\/span>\u9009\u62e9\u901a\u5e38\u57fa\u4e8e\u7edf\u8ba1\u663e\u8457\u6027\uff0c\u53ef\u80fd\u65e0\u6cd5\u6709\u6548\u6355\u6349\u5230\u751f\u7269\u5b66\u673a\u5236\u3002<\/span><\/section>\n

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\u8fd1\u65e5Nature communications<\/em>\u4e0a\u520a\u8f7d\u4e86\u5fb7\u56fd\u6155\u5c3c\u9ed1\u4ea5\u59c6\u970d\u5179\u4e2d\u5fc3\u591a\u4f4d\u5b66\u8005\u7684\u8bba\u6587\u201c\u4e00\u79cd\u5229\u7528\u5148\u9a8c\u77e5\u8bc6\u9009\u62e9\u5173\u7cfb\u7f51\u7edc\u622a\u65ad\u7684\u7b56\u7565\u201d\u3002\u6587\u7ae0\u6307\u51fa\uff0c\u5148\u9a8c\u77e5\u8bc6\u53ef\u4ee5\u6709\u6548\u5730\u8f85\u52a9\u5173\u8054\u7f51\u7edc\u91cd\u6784\u3002\u751a\u81f3\u5f53\u5148\u9a8c\u77e5\u8bc6\u7c97\u7cd9\u3001\u6709\u7f3a\u5931\u3001\u6709\u9519\u8bef\u65f6\uff0c\u8be5\u65b9\u6cd5\u4ecd\u7136\u6709\u6548\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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A strategy to incorporate prior knowledge into correlation network cutoff selection<\/span><\/p>\n

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https:\/\/www.nature.com\/articles\/s41467-020-18675-3<\/span><\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n

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\u5728\u7f51\u7edc\u63a8\u65ad<\/span>\uff08network inference\uff09<\/span>\u98ce\u6f6e\u4e0b\uff0c\u5229\u7528\u5927\u6570\u636e\u91cd\u6784\u751f\u7269\u7f51\u7edc\uff0c\u5df2\u7ecf\u6210\u4e3a\u751f\u547d\u79d1\u5b66\u9886\u57df\u7684\u7814\u7a76\u70ed\u70b9\u3002\u4f8b\u5982\u4ece\u751f\u7269\u7ec4\u5b66\u5927\u6570\u636e\u4e2d\u63d0\u53d6\u51fa\u751f\u7269\u5206\u5b50\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u8fdb\u800c\u9884\u6d4b\u672a\u77e5\u7684\u751f\u7269\u53cd\u5e94\u673a\u5236\u3002<\/span><\/section>\n
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1.\u4f20\u7edf\u65b9\u6cd5\u4e0e\u5148\u9a8c\u77e5\u8bc6\u8f85\u52a9\u65b9\u6cd5<\/strong><\/span><\/p>\n

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\u5178\u578b\u7684\u7f51\u7edc\u63a8\u65ad\u5de5\u4f5c\u6d41\u7a0b\uff0c\u9996\u5148\u662f\u6839\u636e\u9884\u5904\u7406\u7684\u6570\u636e\uff0c\u4f30\u8ba1\u53d8\u91cf\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u5f62\u6210\u76f8\u5173\u77e9\u9635\u3002\u7136\u540e\u6839\u636e\u5047\u8bbe\u68c0\u9a8c\u6765\u5224\u65ad\u54ea\u4e9b\u76f8\u5173\u5173\u7cfb\u662f\u663e\u8457\u7684\u3002\u6700\u540e\u628a\u663e\u8457\u7684\u76f8\u5173\u5173\u7cfb\u6784\u5efa\u6210\u7f51\u7edc<\/span>\uff08network representation\uff09<\/span>\uff0c\u5176\u4e2d\u8282\u70b9\u662f\u6570\u636e\u96c6\u4e2d\u7684\u53d8\u91cf\uff0c\u8fde\u8fb9\u4ee3\u8868\u76f8\u5173\u5173\u7cfb\u3002<\/span><\/section>\n
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\u8fd9\u6837\u7684\u7f51\u7edc\u63a8\u65ad\u8fc7\u7a0b\u867d\u7136\u7b80\u5355\uff0c\u5374\u6709\u660e\u663e\u7f3a\u9677\uff0c\u4ee5\u81f3\u4e8e\u964d\u4f4e\u7f51\u7edc\u63a8\u65ad\u7684\u9c81\u68d2\u6027\u548c\u53ef\u91cd\u590d\u6027\u3002\u9996\u5148\uff0c\u6837\u672c\u91cf\u7684\u589e\u5927\uff0c\u4f1a\u660e\u663e\u5f71\u54cd\u7edf\u8ba1\u7ed3\u679c\uff0c\u4f8b\u5982\u6837\u672c\u91cf\u8d8a\u5927\u5219\u7f51\u7edc\u8d8a\u7a20\u5bc6\u3002\u5176\u6b21\uff0c\u4e0d\u540c\u7684\u68c0\u9a8c\u65b9\u6cd5\u6709\u4e0d\u540c\u7684\u57fa\u672c\u5047\u8bbe\uff0c\u53ef\u80fd\u4f1a\u5f97\u5230\u5b8c\u5168\u4e0d\u540c\u7684\u7f51\u7edc\u3002\u8fd9\u4e9b\u7f51\u7edc\u5c3d\u7ba1\u5728\u7edf\u8ba1\u5b66\u4e0a\u6ca1\u95ee\u9898\uff0c\u5374\u672a\u5fc5\u80fd\u6709\u6548\u8868\u793a\u6f5c\u5728\u7684\u751f\u7269\u673a\u5236<\/strong>\u3002<\/span><\/section>\n
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\u56fe2\uff1a\u57fa\u4e8e\u5148\u9a8c\u77e5\u8bc6\u7684\u7f51\u7edc\u63a8\u65ad\u5de5\u4f5c\u6d41<\/span><\/section>\n
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\u7814\u7a76\u8005\u9996\u5148\u5229\u7528\u5148\u9a8c\u77e5\u8bc6\uff0c\u5c06\u5df2\u77e5\u7684\u4e00\u5b9a\u5b58\u5728\u5173\u8054\u7684\u8282\u70b9\u8fdb\u884c\u8fde\u63a5\uff0c\u6784\u5efa\u4e86\u53c2\u8003\u7f51\u7edc\uff08reference network\uff09<\/strong>\u3002\u7136\u540e\uff0c\u5728\u5bf9\u6bd4\u4e0d\u540c\u9608\u503c\u4e0b\u7684<\/span>\uff08\u63a8\u65ad\u7684\uff09<\/span>\u7f51\u7edc\u4e0e\u5229\u7528\u5148\u9a8c\u77e5\u8bc6\u6784\u5efa\u7684\u8f85\u52a9<\/span>\uff08\u53c2\u8003\uff09<\/span>\u7f51\u7edc\u4e4b\u95f4\u7684\u91cd\u53e0\u7a0b\u5ea6\u540e\uff0c\u9009\u62e9\u91cd\u53e0\u5ea6\u6700\u597d\u7684\u60c5\u51b5\u4f5c\u4e3a\u7f51\u7edc\u63a8\u65ad\u7ed3\u679c\u3002<\/span><\/section>\n
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\u91cd\u53e0\u5ea6\u7531\u771f\u9633\u6027<\/span>\uff08\u540c\u65f6\u51fa\u73b0\u5728\u5173\u8054\u7f51\u7edc\u4e0e\u53c2\u8003\u7f51\u7edc\uff09<\/span>\u3001\u5047\u9633\u6027<\/span>\uff08\u53ea\u5728\u5173\u8054\u7f51\u7edc\u6709\uff09<\/span>\u3001\u771f\u9634\u6027\u3001\u5047\u9634\u6027\u6309 Fisher \u7cbe\u786e\u68c0\u9a8c\u65b9\u6cd5\u8ba1\u7b97\u3002<\/span><\/section>\n
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\u4ece\u5173\u8054\u7f51\u7edc\u4e2d\uff0c\u641c\u7d22\u51fa\u4e0e\u53c2\u8003\u7f51\u7edc\u91cd\u53e0\u7a0b\u5ea6\u6700\u5927\u7684\u7f51\u7edc\uff0c\u5e76\u622a\u53d6\u8be5\u7f51\u7edc\uff0c\u5373\u4e3a\u6700\u4f18\u7f51\u7edc\uff08optimal network\uff09<\/span><\/strong>\u3002<\/span><\/section>\n
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2.\u5728\u5177\u4f53\u7f51\u7edc\u4e2d\u9a8c\u8bc1<\/strong><\/span><\/p>\n

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\u4e3a\u4e86\u9a8c\u8bc1\u8fd9\u4e00\u65b9\u6cd5\u7684\u53ef\u9760\u6027\uff0c\u7814\u7a76\u8005\u5728\u591a\u79cd\u751f\u7269\u6570\u636e\u96c6\u4e0a\u8fdb\u884c\u4e86\u5b9e\u9a8c\u3002\u7531\u4e8eIgG\u7cd6\u7ec4\u5b66\u5df2\u7ecf\u88ab\u5f88\u597d\u5730\u63cf\u8ff0\uff0c\u4fbf\u4e8e\u68c0\u9a8c\uff0c\u6240\u4ee5\u7814\u7a76\u8005\u9996\u5148\u7528\u5b83\u6765\u6d4b\u8bd5\u7f51\u7edc\u63a8\u65ad\u65b9\u6cd5\u7684\u6709\u6548\u6027\u3002<\/span><\/section>\n
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\u56fe4\uff1a\u514d\u75ab\u7403\u86cb\u767dG\uff08IgG\uff09\u805a\u7cd6\u7ed3\u6784\u7684\u5408\u6210\u8def\u5f84<\/span><\/section>\n
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\u5229\u7528\u8be5\u7f51\u7edc\u4f5c\u4e3a\u5148\u9a8c\u77e5\u8bc6\u5bf9\u5177\u4f53\u7f51\u7edc\u8fdb\u884c\u91cd\u6784\uff0c\u7ed3\u679c\u5982\u56fe5\u3002\u7eb5\u8f74\u8868\u793a\u4e0d\u540c\u9608\u503c\u4e0b\u7684Fisher\u68c0\u9a8c\u7684p\u503c\uff0c\u8be5\u6307\u6807\u53cd\u6620\u4e86\u88ab\u91cd\u6784\u7f51\u7edc\u4e0e\u53c2\u8003\u7f51\u7edc\u7684\u91cd\u53e0\u7a0b\u5ea6\u3002\u5173\u8054\u7f51\u7edc\u4e0e\u751f\u7269\u5b66\u53c2\u8003\u7f51\u7edc\u4ea7\u751f\u6700\u5927\u91cd\u53e0\u65f6\uff0c\u79f0\u4e3a\u6700\u4f18\u622a\u65ad<\/span>\uff08optimal cutoff\uff09<\/span>\u3002<\/span><\/section>\n
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\u56fe\u4e2d\u7684\u865a\u7ebf\u5219\u4ee3\u8868\u5728\u539f\u59cb\u6570\u636e\u77e9\u9635\u4e0a\uff0c\u5229\u7528GeneNet\u7b97\u6cd5\uff0c\u4ee5\u4e0d\u540c\u663e\u8457\u6027\u8861\u91cf\u6807\u51c6\u7ed9\u51fa\u7684\u622a\u65ad<\/span>\uff08cutoff\uff09<\/span>\uff0c\u5373\u9608\u503c\u3002<\/span><\/section>\n
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\u663e\u7136\uff0cPearson\u4e0eparcor\u65b9\u6cd5\u7684\u6548\u679c\u5e76\u4e0d\u597d\uff0c\u800c\u4f7f\u7528\u53c2\u8003\u7f51\u7edc\u6700\u4f18\u622a\u65ad\u5f97\u5230\u7684\u6700\u4f18\u7684GeneNet\u7f51\u7edc\u975e\u5e38\u63a5\u8fd1GeneNet\u7f51\u7edc\u6700\u4f18\u7684\u7edf\u8ba1\u622a\u65ad\u70b9<\/span>\uff08\u865a\u7ebfFDR=0.05\uff09<\/span>\u3002<\/span><\/section>\n
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3.\u5148\u9a8c\u77e5\u8bc6\u8d28\u91cf\u4e0d\u540c\uff0c<\/strong><\/span><\/p>\n

\u7f51\u7edc\u63a8\u65ad\u7ed3\u679c\u4f9d\u65e7<\/strong><\/span><\/p>\n

<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

 <\/span><\/p>\n

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 <\/span><\/section>\n
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             <\/span><\/section>\n
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 <\/span><\/section>\n
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 <\/span><\/section>\n
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 <\/span><\/section>\n
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 <\/span><\/section>\n
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4.\u524d\u666f<\/strong><\/span><\/p>\n

<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

 <\/span><\/p>\n

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 <\/span><\/section>\n
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             <\/span><\/section>\n
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 <\/span><\/section>\n
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<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/section>\n

\u96c6\u667a\u6591\u56fe\u6536\u5f55\u6765\u81ea Nature\u3001Science <\/em>\u7b49\u9876\u520a\u53caarXiv\u9884\u5370\u672c\u7f51\u7ad9\u7684\u6700\u65b0\u8bba\u6587\uff0c\u5305\u62ec\u590d\u6742\u7cfb\u7edf\u3001\u7f51\u7edc\u79d1\u5b66\u3001\u8ba1\u7b97\u793e\u4f1a\u79d1\u5b66\u7b49\u7814\u7a76\u65b9\u5411\u3002\u6bcf\u5929\u6301\u7eed\u66f4\u65b0\uff0c\u626b\u7801\u5373\u53ef\u83b7\u53d6\uff1a<\/span><\/p>\n


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\u63a8\u8350\u9605\u8bfb<\/strong><\/span><\/p>\n

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\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/a><\/span><\/strong><\/span><\/section>\n

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\u96c6\u667a\u4ff1\u4e50\u90e8QQ\u7fa4\uff5c877391004<\/span><\/strong><\/p>\n

\u5546\u52a1\u5408\u4f5c\u53ca\u6295\u7a3f\u8f6c\u8f7d\uff5cswarma@swarma.org
<\/span><\/strong><\/p>\n

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\u25c6 <\/span>\u25c6 <\/span>\u25c6<\/span><\/span><\/strong><\/strong><\/h1>\n<\/section>\n

\u641c\u7d22\u516c\u4f17\u53f7\uff1a\u96c6\u667a\u4ff1\u4e50\u90e8<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u52a0\u5165\u201c\u6ca1\u6709\u56f4\u5899\u7684\u7814\u7a76\u6240\u201d<\/span><\/strong><\/span><\/p>\n

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<\/p>\n<\/section>\n

\u8ba9\u82f9\u679c\u7838\u5f97\u66f4\u731b\u70c8\u4e9b\u5427\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\ud83d\udc47\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u8ffd\u8e2a\u590d\u6742\u79d1\u5b66\u9876\u520a\u8bba\u6587<\/span><\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

  \u5bfc\u8bed \u5173\u8054\u7f51\u7edc\uff08correlation network\uff09\u5e38\u5e38\u88ab\u7528\u4e8e\u63d0\u53d6\u751f\u7269\u7ec4\u5b66\u4e2d\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4f46\u5176\u8fde\u8fb9\u9009\u62e9\u901a\u5e38\u57fa\u4e8e\u7edf\u8ba1\u663e\u8457\u6027\uff0c\u53ef\u80fd\u65e0\u6cd5\u6709\u6548\u6355\u6349\u5230\u751f\u7269\u5b66\u673a\u5236\u3002 \u8fd1\u65e5Nature communications\u4e0a\u520a\u8f7d\u4e86\u5fb7\u56fd\u6155\u5c3c\u9ed1\u4ea5\u59c6\u970d\u5179\u4e2d\u5fc3\u591a\u4f4d\u5b66\u8005\u7684\u8bba\u6587\u201c\u4e00\u79cd\u5229\u7528\u5148\u9a8c\u77e5\u8bc6\u9009\u62e9\u5173\u7cfb\u7f51\u7edc\u622a\u65ad\u7684\u7b56\u7565…<\/p>\n","protected":false},"author":1,"featured_media":21440,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/21451"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21451"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/21451\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/21440"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21451"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21451"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21451"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=21451"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}