{"id":22636,"date":"2020-12-11T23:14:15","date_gmt":"2020-12-11T15:14:15","guid":{"rendered":"https:\/\/swarma.org\/?p=22636"},"modified":"2020-12-11T23:14:15","modified_gmt":"2020-12-11T15:14:15","slug":"science%ef%bc%9a%e8%87%aa%e7%84%b6%e9%80%89%e6%8b%a9%e6%80%8e%e6%a0%b7%e5%bd%b1%e5%93%8d%e6%9c%89%e6%9c%ba%e4%bd%93%e7%9a%84%e9%80%82%e5%ba%94%e8%83%bd%e5%8a%9b%e5%92%8c%e8%bf%9b%e5%8c%96","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=22636","title":{"rendered":"Science\uff1a\u81ea\u7136\u9009\u62e9\u600e\u6837\u5f71\u54cd\u6709\u673a\u4f53\u7684\u9002\u5e94\u80fd\u529b\u548c\u8fdb\u5316"},"content":{"rendered":"
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\u4e8e12\u67084\u65e5\u53d1\u8868\u5728 Science <\/em>\u6742\u5fd7\u4e0a\u7684\u6587\u7ae0\u5c31\u8fd9\u4e00\u95ee\u9898\uff0c\u7ed9\u51fa\u4e86\u4ee4\u4eba\u60ca\u8bb6\u7684\u7b54\u6848\u3002\u8be5\u6587\u7ae0\u7531\u4f9b\u804c\u4e8e\u82cf\u9ece\u4e16\u5927\u5b66\u548c\u5723\u5854\u83f2\u7814\u7a76\u6240\u7684 Andreas Wagner \u6240\u9886\u5bfc\u7684\u7814\u7a76\u56e2\u961f\u6240\u53d1\u8868\uff0c\u4ed6\u4eec\u5bf9\u4e00\u79cd\u6d77\u6d0b\u65e0\u810a\u690e\u52a8\u7269\u7684\u9ec4\u8272\u83b9\u5149\u86cb\u767d\u8fdb\u884c\u4e86\u81ea\u7136\u9009\u62e9\u7684\u5b9e\u9a8c\u3002<\/span><\/p>\n


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Selection enhances protein evolvability by increasing mutational robustness and foldability<\/span><\/span><\/p>\n

\u8bba\u6587\u5730\u5740\uff1a<\/span><\/p>\n

https:\/\/science.sciencemag.org\/content\/370\/6521\/eabb5962<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n


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\u9002\u5e94\u6027\u666f\u89c2\uff08adaptive landscapes\uff09<\/span><\/strong>\u5728\u6f14\u5316\u7406\u8bba\u4e2d\u5360\u636e\u7740\u91cd\u8981\u7684\u4f4d\u7f6e\u3002\u5982\u4e0a\u56fe\u6240\u793a\uff0c\u6a2a\u5411\u7684\u5750\u6807\u8868\u793a\u7684\u662f\u591a\u79cd\u6027\u72b6\uff0c\u800c\u7eb5\u8f74\u5219\u8868\u793a\u9002\u5e94\u80fd\u529b\u7684\u9ad8\u4f4e\u3002\u4e0a\u56fe\u5047\u8bbe\u8f83\u5f3a\u7684\u81ea\u7136\u9009\u62e9\u80fd\u5e26\u6765\u8f83\u5f3a\u9002\u5e94\u80fd\u529b\uff0c\u4ece\u800c\u8ba9\u79cd\u7fa4\u7684\u6f14\u5316\u5f97\u4ee5\u7ed5\u8fc7\u9002\u5e94\u6027\u7684\u4f4e\u8c37<\/strong>\u3002\u8fd9\u4e00\u70b9\u5176\u5b9e\u4e0e\u68af\u5ea6\u4e0b\u964d\u7b49\u51fd\u6570\u6c42\u89e3\u7b97\u6cd5\u7684\u6539\u8fdb\u65b9\u6848\u7c7b\u4f3c\u3002<\/span><\/section>\n

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\u8be5\u8bba\u6587\u7b2c\u4e00\u4f5c\u8005\u3001\u82cf\u9ece\u4e16\u5927\u5b66\u7684 Jia Zheng \u8ba4\u4e3a\uff0c\u8fd9\u6837\u7684\u7814\u7a76\u7ed3\u679c\u53ef\u4ee5\u8bf4\u662f\u4e00\u4e2a\u60ca\u559c\u3002\u56e0\u4e3a\u7ed3\u679c\u8868\u660e\uff0c\u81ea\u7136\u9009\u62e9\u7684\u9002\u5e94\u6027\u4e0e\u9c81\u68d2\u6027\u5e76\u4e0d\u51b2\u7a81\u3002\u867d\u7136\u7a81\u53d8\u4f1a\u635f\u5bb3\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u7a33\u5b9a\u6027\u5e76\u5f71\u54cd\u86cb\u767d\u8d28\u7684\u6b63\u786e\u6298\u53e0\uff0c\u4f46\u80fd\u589e\u5f3a\u9c81\u68d2\u6027\u7684\u7a81\u53d8\u4f1a\u51cf\u8f7b\u8fd9\u79cd\u5f71\u54cd\u3002\u9c81\u68d2\u6027\u9ad8\u7684\u86cb\u767d\u8d28\u80fd\u53d1\u6325\u5176\u529f\u80fd\u7684\u673a\u4f1a\u5c31\u66f4\u591a\uff0c\u4e5f\u5c31\u80fd\u6f14\u5316\u51fa\u65b0\u7684\u6027\u72b6\u3002<\/strong><\/span><\/span><\/p>\n

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\u201c\u636e\u6211\u6240\u77e5\uff0c\u8fd9\u662f\u7b2c\u4e00\u4e2a\u8bc1\u660e\u4e86\u81ea\u7136\u9009\u62e9\u53ef\u4ee5\u4fc3\u8fdb\u7269\u79cd\u9002\u5e94\u80fd\u529b\u7684\u5b9e\u9a8c\u3002\u201dWagner \u8868\u793a\uff0c\u201c\u867d\u7136\u6f14\u5316\u7406\u8bba\u81f3\u4eca\u4ecd\u53d7\u4eba\u8d28\u7591\uff0c\u4f46\u662f\u6211\u4eec\u4e0d\u4ec5\u4ece\u5316\u77f3\u4e2d\u770b\u5230\u4e86\u7269\u79cd\u6f14\u5316\u7684\u75d5\u8ff9\uff0c\u73b0\u5728\u4e5f\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u771f\u5b9e\u5730\u89c2\u5bdf\u5230\u4e86\u8fd9\u4e00\u73b0\u8c61\u3002<\/strong>\u201d<\/span><\/span><\/p>\n

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\u957f\u671f\u4ee5\u6765\uff0c\u751f\u7269\u7684\u6f14\u5316\u80fd\u529b\u672c\u8eab\u662f\u5426\u80fd\u591f\u6f14\u5316\u5c31\u662f\u4e00\u4e2a\u5907\u53d7\u4e89\u8bae\u7684\u8bdd\u9898\u3002\u4e00\u4e9b\u4eba\u8ba4\u4e3a\u81ea\u7136\u9009\u62e9\u5e76\u4e0d\u80fd\u76f4\u63a5\u7684\u5f71\u54cd\u5230\u7269\u79cd\u7684\u6f14\u5316\uff0c\u800c\u662f\u901a\u8fc7\u9002\u5e94\u6027\u6765\u95f4\u63a5\u5730\u5b9e\u73b0\u7269\u79cd\u6f14\u5316\u3002Wagner \u5e0c\u671b\u4ed6\u4eec\u7684\u7814\u7a76\u5bf9\u7ed3\u675f\u8fd9\u4e00\u4e89\u8bae\u6709\u6240\u5e2e\u52a9\u3002Wagner \u8bf4\uff1a\u201c\u73b0\u5728\uff0c\u6211\u4eec\u8ba4\u4e3a\uff0c\u9002\u5e94\u6027\u548c\u81ea\u7136\u9009\u62e9\u4f1a\u540c\u65f6\u5b58\u5728\u3002<\/strong>\u201d<\/span><\/span><\/p>\n

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\u53c2\u8003\u8d44\u6599<\/span><\/strong><\/strong><\/span><\/section>\n
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\u590d\u6742\u79d1\u5b66\u6700\u65b0\u8bba\u6587<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u96c6\u667a\u6591\u56fe\u9876\u520a\u8bba\u6587\u901f\u9012\u680f\u76ee\u4e0a\u7ebf\u4ee5\u6765\uff0c\u6301\u7eed\u6536\u5f55\u6765\u81eaNature\u3001Science<\/span>\u7b49\u9876\u520a\u7684\u6700\u65b0\u8bba\u6587\uff0c\u8ffd\u8e2a\u590d\u6742\u7cfb\u7edf\u3001\u7f51\u7edc\u79d1\u5b66\u3001\u8ba1\u7b97\u793e\u4f1a\u79d1\u5b66\u7b49\u9886\u57df\u7684\u524d\u6cbf\u8fdb\u5c55\u3002\u73b0\u5728\u6b63\u5f0f\u63a8\u51fa\u8ba2\u9605\u529f\u80fd\uff0c\u6bcf\u5468\u901a\u8fc7\u5fae\u4fe1\u670d\u52a1\u53f7\u300c\u96c6\u667a\u6591\u56fe\u300d\u63a8\u9001\u8bba\u6587\u4fe1\u606f\u3002\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\u5373\u53ef\u4e00\u952e\u8ba2\u9605\uff1a<\/span>
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\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/span><\/p>\n