{"id":22890,"date":"2020-12-24T13:38:23","date_gmt":"2020-12-24T05:38:23","guid":{"rendered":"https:\/\/swarma.org\/?p=22890"},"modified":"2020-12-24T13:38:23","modified_gmt":"2020-12-24T05:38:23","slug":"%e4%b8%ad%e5%9b%bd%e5%9b%a2%e9%98%9f%e5%bc%80%e5%8f%91%e9%ab%98%e6%80%a7%e8%83%bd%e7%bb%86%e8%83%9e%e9%80%9a%e8%ae%af%e7%b3%bb%e7%bb%9f%ef%bc%8c%e8%a7%a3%e5%86%b3%e5%a4%9a%e7%bb%86%e8%83%9e%e7%b3%bb","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=22890","title":{"rendered":"\u4e2d\u56fd\u56e2\u961f\u5f00\u53d1\u9ad8\u6027\u80fd\u7ec6\u80de\u901a\u8baf\u7cfb\u7edf\uff0c\u89e3\u51b3\u591a\u7ec6\u80de\u7cfb\u7edf\u5de5\u7a0b\u96be\u9898"},"content":{"rendered":"
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\u5b5f\u51e1\u5eb7 | \u4f5c\u8005<\/p>\n

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\u5728\u5408\u6210\u751f\u7269\u5b66\u9886\u57df\uff0c\u6211\u4eec\u5df2\u7ecf\u5f00\u53d1\u4e86\u591a\u79cd\u5408\u6210\u4eba\u5de5\u901a\u8baf\u7cfb\u7edf\uff0c\u5982synthetic quorum sensing, scalable peptide-GPCR signalling\u3001synthetic morphogen system\u7b49\u7b49\u3002\u7136\u800c\uff0c\u73b0\u6709\u4f18\u8d28\u7684\u7ec6\u80de\u95f4\u901a\u8baf\u5de5\u5177\u4ecd\u7136\u6709\u9650\uff0c\u4e3b\u8981\u6709\u4e24\u4e2a\u65b9\u9762\u9650\u5236\u4e86\u8fd9\u7c7b\u5de5\u5177\u7684\u5b9e\u7528\u6027\uff1a<\/p>\n

\u2460\u901a\u7528\u6027\uff1a\u7406\u60f3\u7684\u7ec6\u80de-\u7ec6\u80de\u901a\u8baf\u7cfb\u7edf\u5e94\u8be5\u4ee5\u6a21\u5757\u5316\u7684\u65b9\u5f0f\u5de5\u4f5c\uff0c\u540c\u65f6\u9700\u8981\u6ee1\u8db3\u8de8\u751f\u7269\u754c\uff08\u7ec6\u83cc\u3001\u771f\u83cc\u3001\u52a8\u7269\u7b49\uff09\u901a\u8baf\u7684\u573a\u666f\uff0c\u80fd\u591f\u517c\u5bb9\u6216\u8005\u8fc1\u79fb\u5230\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\u3002\u7136\u800c\uff0c\u73b0\u6709\u7684\u7cfb\u7edf\u8981\u4e48\u9700\u8981\u4eba\u5de5\u6dfb\u52a0\u5916\u6e90\u6027\u524d\u4f53\u7528\u4e8e\u5408\u6210\u4fe1\u53f7\u5206\u5b50\uff0c\u8981\u4e48\u65e0\u6cd5\u4ece\u4e00\u4e2a\u7269\u79cd\u8f6c\u79fb\u5230\u53e6\u4e00\u4e2a\u7269\u79cd\u4e0a\uff0c\u5728\u4e0d\u540c\u751f\u7269\u5e95\u76d8\u4e2d\u7684\u517c\u5bb9\u6027\u5f88\u5dee\u3002<\/p>\n

\u2461 \u6b63\u4ea4\u6027\uff1a\u7406\u60f3\u7684\u7ec6\u80de-\u7ec6\u80de\u901a\u8baf\u7cfb\u7edf\u4f9d\u9760\u4e00\u7cfb\u5217\u7edd\u7f18\u6027\u826f\u597d\u7684\u901a\u9053\u6765\u8fdb\u884c\u6b63\u786e\u7684\u4fe1\u53f7\u4f20\u9012\u3002\u5728\u7535\u5b50\u4ea7\u54c1\u4e2d\uff0c\u4e0d\u540c\u901a\u9053\u7684\u7edd\u7f18\u53ef\u4ee5\u901a\u8fc7\u7a7a\u95f4\u9694\u79bb\u6765\u5b9e\u73b0\u7684\uff0c\u800c\u5728\u751f\u7269\u7cfb\u7edf\u4e2d\uff0c\u6700\u53ef\u884c\u7684\u5b9e\u73b0\u7edd\u7f18\u7684\u65b9\u6cd5\u662f\u901a\u8fc7\u300c\u5316\u5b66\u6b63\u4ea4 chemical orthogonality\u300d\u3002\u4f46\u662f\u73b0\u6709\u7684\u7ec6\u80de\u95f4\u901a\u8baf\u5de5\u5177\u6b63\u4ea4\u6027\u4ea4\u53c9\uff0c\u5728\u540c\u4e00\u4e2a\u7ec6\u80de\u6216\u8005\u7fa4\u4f53\u4e2d\u4f7f\u7528\u65f6\u4f1a\u76f8\u4e92\u4ea7\u751f\u5e72\u6270\u3002<\/p>\n

\u4e3a\u4e86\u89e3\u51b3\u4e0a\u9762\u63d0\u5230\u7684\u95ee\u9898\uff0c\u6765\u81ea\u4e2d\u56fd\u79d1\u5b66\u9662\u3001\u5317\u4eac\u5927\u5b66\u4ee5\u53ca\u84dd\u6676\u5fae\u751f\u7269\u7684\u7814\u7a76\u56e2\u961f\u57fa\u4e8e\u7fa4\u4f53\u611f\u5e94\u7cfb\u7edf\uff08Quorum Sensing\uff09\u4ece\u5934\u8bbe\u8ba1\u4e86\u4e00\u6574\u5957\u5177\u6709\u901a\u7528\u6027\u9ad8\u3001\u6b63\u4ea4\u6027\u5f3a\u3001\u53ef\u4ee5\u8de8\u751f\u7269\u754c\u901a\u8baf\u7684\u5408\u6210\u751f\u7269\u5b66\u5de5\u5177\u7bb1\uff0c\u76f8\u5173\u6587\u7ae0\u53d1\u8868\u5728Nature Communications\u4e0a\u3002<\/p>\n

\u901a\u8fc7\u5bf9\u5143\u4ef6\u6316\u6398\u3001\u7406\u6027\u8bbe\u8ba1\u4ee5\u53ca\u5b9a\u5411\u8fdb\u5316\uff0c\u8fd9\u9879\u5de5\u4f5c\u4e00\u5171\u5f00\u53d1\u4e8610\u5957\u5168\u65b0\u6216\u4f18\u5316\u8fc7\u7684\u7ec6\u80de\u901a\u8baf\u5de5\u5177\uff0c\u5176\u7efc\u5408\u6027\u80fd\u8fdc\u8d85\u4f20\u7edf\u7684\u7fa4\u4f53\u611f\u5e94\u4fe1\u53f7\u7cfb\u7edf\u3002\u8fd9\u5957\u5de5\u5177\u5c06\u6781\u5927\u5730\u6269\u5c55\u5408\u6210\u751f\u7269\u5b66\u5728\u591a\u7ec6\u80de\u751f\u7269\u5de5\u7a0b\u4e2d\u7684\u80fd\u529b\uff0c\u4e3a\u5728\u7ec6\u80de\u8fdb\u884c\u5927\u89c4\u6a21\u751f\u7269\u8ba1\u7b97\u63d0\u4f9b\u4e86\u575a\u5b9e\u7684\u57fa\u7840\uff0c\u4e5f\u4e3a\u5305\u62ec\u4eba\u5de5\u751f\u6001\u7cfb\u7edf\u548c\u667a\u80fd\u7ec4\u7ec7\u5728\u5185\u7684\u590d\u6742\u591a\u7ec6\u80de\u5de5\u7a0b\u94fa\u5e73\u4e86\u9053\u8def<\/p>\n


\u8bba\u6587\u9898\u76ee\uff1a
De novo design of an intercellular signaling toolbox for multi-channel cell-cell communication and biological computation
\u8bba\u6587\u5730\u5740\uff1a
https:\/\/www.nature.com\/articles\/s41467-020-17993-w<\/p>\n

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1.\u89e3\u51b3\u901a\u7528\u6027\uff1a\u4ece\u901a\u7528\u7684\u7ec6\u80de\u4ee3\u8c22\u7269\u51fa\u53d1<\/p>\n

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\u7814\u7a76\u4eba\u5458\u5728Kyoto Encyclopedia of Genes and Genomes (KEGG) \u6570\u636e\u5e93\u548c\u6587\u732e\u4e2d\u5bf9\u6b21\u7ea7\u4ee3\u8c22\u7269\u6570\u636e\u548c\u5bf9\u5e94\u7684\u8f6c\u5f55\u8c03\u63a7\u56e0\u5b50\u6309\u7167\u4ee5\u4e0b\u6807\u51c6\u8fdb\u884c\u4e86\u7b5b\u9009\uff1a
(i) \u4fe1\u53f7\u5206\u5b50\u53ef\u4ee5\u751f\u7269\u5408\u6210\uff0c\u80fd\u591f\u81ea\u7531\u5730\u8de8\u7ec6\u80de\u819c\u6269\u6563\uff1b(ii) \u4fe1\u53f7\u5206\u5b50\u5e94\u80fd\u88ab\u7279\u5f02\u6027\u8f83\u5f3a\u7684\u8f6c\u5f55\u56e0\u5b50\u611f\u77e5\uff1b(iii) \u4fe1\u53f7\u5206\u5b50\u7684\u524d\u4f53\u5fc5\u987b\u662f\u539f\u6838\u7ec6\u80de\u548c\u771f\u6838\u7ec6\u80de\u4e2d\u901a\u7528\u7684\u7ec6\u80de\u5185\u4ee3\u8c22\u7269\uff1b(iv) \u5408\u6210\u6b64\u4fe1\u53f7\u5206\u5b50\u7684\u751f\u7269\u9014\u5f84\u5305\u542b\u7684\u9176\u603b\u6570\u6700\u5c11\u3002
\u4ece\u901a\u7528\u7684\u7ec6\u80de\u4ee3\u8c22\u7269\u51fa\u53d1\u7b5b\u9009\u6709\u6f5c\u529b\u7684\u7ec6\u80de\u95f4\u901a\u8baf\u7cfb\u7edf
\u7814\u7a76\u4eba\u5458\u6700\u7ec8\u7b5b\u9009\u51fa\u4e8610\u4e2a\u5019\u9009\u7684\u7ec6\u80de\u95f4\u4fe1\u53f7\u901a\u8baf\u7cfb\u7edf\uff0c\u6765\u81ea\u4e8e\u591a\u79cd\u7269\u79cd\uff0c\u5305\u62ecPseudomonas, Rhodobacter, Streptomyces, Photorhabdus, Bradyrhizobium, Yersinia\u4ee5\u53ca\u9ad8\u7b49\u690d\u7269\u3002\u5728\u540e\u7eed\u7684\u6d4b\u8bd5\u4e2d\uff0c10\u4e2a\u5019\u9009\u7cfb\u7edf\u4e2d\u76846\u4e2a\u7cfb\u7edf\u8fbe\u5230\u4e86\u8f83\u4e3a\u7406\u60f3\u7684\u4fe1\u53f7\u54cd\u5e94\u6548\u679c\u3002

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6\u4e2a\u4ece\u5934\u8bbe\u8ba1\u7684\u7ec6\u80de\u95f4\u901a\u8baf\u7cfb\u7edf
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2.\u901a\u7528\u6027\u8bbe\u8ba1\u6253\u7834\u4e86\u4e0d\u540c\u751f\u7269\u754c\u4e4b\u95f4\u4ea4\u6d41\u7684\u969c\u788d<\/p>\n


\u4e3a\u4e86\u5b9e\u73b0\u8de8\u7269\u79cd\u548c\u8de8\u751f\u7269\u754c\u7684\u901a\u4fe1\uff0c\u4fe1\u53f7\u53d1\u9001\u6a21\u5757\u548c\u63a5\u6536\u6a21\u5757\u9700\u8981\u6709\u80fd\u529b\u5728\u5404\u79cd\u7ec6\u80de\u6a21\u578b\u4e2d\u53d1\u6325\u4f5c\u7528\u3002\u300c\u901a\u7528\u7684\u4ee3\u8c22\u5206\u5b50\u300d\u8bbe\u8ba1\u7b56\u7565\u4e3a\u6253\u7834\u4e0d\u540c\u751f\u7269\u754c\u4e4b\u95f4\u4ea4\u6d41\u7684\u969c\u788d\u63d0\u4f9b\u4e86\u6700\u5fc5\u8981\u7684\u4fdd\u969c\u3002<\/p>\n

\u901a\u8fc7\u5229\u7528\u7269\u79cd\u7279\u5f02\u6027\u542f\u52a8\u5b50\u66ff\u6362\u5927\u80a0\u6746\u83cc\u542f\u52a8\u5b50\uff0c\u7814\u7a76\u4eba\u5458\u5efa\u7acb\u4e86\u8de8\u751f\u7269\u754c\u7684\u7ec6\u80de\u901a\u4fe1\u7cfb\u7edf\uff0c\u5305\u62ec(i)\u4ece\u5927\u80a0\u6746\u83cc\u5230\u9175\u6bcd\u7684DAPG-PhlF\u901a\u9053\uff0c(ii)\u4ece\u9175\u6bcd\u5230\u5927\u80a0\u6746\u83cc\u7684Sal-NahR\u901a\u9053\uff0c\u4ee5\u53ca(iii)\u4eceHEK-293T\u4eba\u7ec6\u80de\u7cfb\u5230\u5927\u80a0\u6746\u83cc\u7684pC-RpaR\u901a\u9053\u3002\u6240\u6709\u7684\u901a\u8baf\u7cfb\u7edf\u90fd\u6210\u529f\u5730\u6fc0\u6d3b\u3002\u8fd9\u5145\u5206\u5c55\u793a\u4e86\u8fd9\u4e9b\u901a\u8baf\u5de5\u5177\u7684\u901a\u7528\u6027\u53ca\u5176\u8de8\u751f\u7269\u754c\u4ea4\u6d41\u7684\u80fd\u529b\u3002 <\/p>\n


\u901a\u8baf\u5de5\u5177\u5177\u6709\u8de8\u751f\u7269\u754c\u4ea4\u6d41\u7684\u80fd\u529b
\u675c\u6c9b\u5728\u63a5\u53d7\u91c7\u8bbf\u65f6\u63d0\u5230\uff1a\u201c\u901a\u7528\u6027\u7684\u610f\u4e49\u5728\u4e8e\u6700\u5927\u5316\u7ec6\u80de\u901a\u8baf\u7cfb\u7edf\u7684\u9002\u7528\u573a\u666f\uff0c\u4f7f\u6211\u4eec\u7684\u5de5\u4f5c\u66f4\u52a0\u6709\u7528\u3002\u6211\u4eec\u8bbe\u8ba1\u7684\u7cfb\u7edf\u662f\u5728\u5927\u80a0\u6746\u83cc\u4e2d\u523b\u753b\u7684\uff0c\u4f46\u6211\u4eec\u7684\u76ee\u7684\u7edd\u4e0d\u662f\u5355\u5355\u4e3a\u4e86\u5728\u5927\u80a0\u6746\u83cc\u4e2d\u4f7f\u7528\uff0c\u90a3\u6837\u7ec6\u80de\u901a\u8baf\u7684\u610f\u4e49\u548c\u4f7f\u7528\u573a\u666f\u5c31\u5927\u6253\u6298\u6263\u4e86\u3002\u4f8b\u5982\uff0c\u6bd4\u5982\u5bf9\u53d1\u9175\u8fdb\u884c\u81ea\u52a8\u63a7\u5236\uff0c\u9700\u8981\u8003\u8651\u7684\u76ee\u6807\u5bbf\u4e3b\u5f80\u5f80\u662f\u7ec6\u83cc\u3001\u653e\u7ebf\u83cc\u3001\u94fe\u9709\u83cc\u7b49\u539f\u6838\u751f\u7269\uff0c\u4e5f\u53ef\u80fd\u662f\u9175\u6bcd\u8fd9\u79cd\u771f\u6838\u5355\u7ec6\u80de\u751f\u7269\uff1b\u5bf9\u591a\u7ec6\u80de\u884c\u4e3a\u8fdb\u884c\u5efa\u6a21\u6216\u8005\u4eba\u4e3a\u63a7\u5236\u7b49\u7814\u7a76\uff0c\u4e5f\u4e0d\u53ef\u80fd\u5c40\u9650\u4e8e\u5927\u80a0\u6746\u83cc\u3002\u7531\u4e8e\u6211\u4eec\u6210\u529f\u7684\u5728\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e2d\u5b8c\u6210\u4e86\u7ec6\u80de\u901a\u8baf\u7684\u8fc1\u79fb\uff0c\u6253\u5f00\u4e86\u66f4\u591a\u7684\u53ef\u80fd\u6027\u3002\u6bd4\u5982\u57fa\u4e8e\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e4b\u95f4\u7684\u901a\u8baf\uff0c\u53ef\u4ee5\u7814\u7a76\u7ec6\u80de\u5206\u5316\u3001\u7ec4\u7ec7\u53d1\u80b2\u7b49\uff0c\u4e43\u81f3\u672a\u6765\u4eba\u9020\u5668\u5b98\u7684\u5efa\u9020\u7b49\u3002\u8fd9\u4e9b\u6700\u7ec8\u90fd\u79bb\u4e0d\u5f00\u901a\u7528\u6027\u7684\u7ec6\u80de\u95f4\u901a\u8baf\u5de5\u5177\u3002\u5f53\u7136\uff0c\u5728\u5c06\u67d0\u4e2a\u7cfb\u7edf\u8f6c\u79fb\u5230\u4e00\u4e2a\u65b0\u7684\u7269\u79cd\u4e2d\u7684\u65f6\u5019\uff0c\u9700\u8981\u5f88\u591a\u8c03\u8bd5\u548c\u4fee\u6539\uff0c\u4f46\u5176\u4fe1\u53f7\u5206\u5b50\u662f\u4e0d\u53d8\u7684\uff0c\u57fa\u672c\u7684\u4fe1\u53f7\u5206\u5b50\u5408\u6210\u9014\u5f84\u548c\u611f\u5e94\u539f\u7406\u4e5f\u662f\u4e0d\u53d8\u7684\u3002\u201d <\/p>\n


3.\u89e3\u51b3\u6b63\u4ea4\u6027\uff1a\u5229\u7528\u751f\u7269\u5408\u6210\u5206\u5b50\u4e0e\u8f6c\u5f55\u56e0\u5b50\u7684\u591a\u6837\u6027<\/p>\n

\u5f53\u591a\u4e2a\u901a\u8baf\u901a\u9053\u96c6\u6210\u5728\u540c\u4e00\u57fa\u56e0\u7ebf\u8def\u4e2d\u65f6\uff0c\u53ef\u80fd\u4f1a\u5728\u300c\u4fe1\u53f7\u611f\u5e94\u300d\u548c\u300c\u542f\u52a8\u5b50\u54cd\u5e94\u300d\u4e24\u4e2a\u5c42\u9762\u53d1\u751f\u5e72\u6270\u3002\u4f20\u7edf\u4e0a\uff0c\u5b83\u4eec\u5206\u522b\u88ab\u5b9a\u4e49\u4e3a\u300c\u4fe1\u53f7\u4ea4\u53c9\u5e72\u6270\u300d\u548c\u300c\u542f\u52a8\u5b50\u4ea4\u53c9\u5e72\u6270\u300d\u3002
\u6587\u7ae0\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u4e2d\u79d1\u9662\u5fae\u751f\u7269\u6240\u52a9\u7406\u7814\u7a76\u5458\u8d75\u4f1a\u4f1f\u5728\u63a5\u53d7\u91c7\u8bbf\u65f6\u8bf4\uff1a\u201c\u751f\u7269\u5143\u5668\u4ef6\u7684\u6a21\u5757\u5316\u4e0e\u6b63\u4ea4\u5316\u662f\u5408\u6210\u751f\u7269\u5b66\uff0c\u7279\u522b\u662f\u5728\u8bbe\u8ba1\u590d\u6742\u57fa\u56e0\u7ebf\u8def\u8fc7\u7a0b\u7684\u57fa\u7840\u79d1\u5b66\u95ee\u9898\u3002\u6a21\u5757\u5316\u548c\u6b63\u4ea4\u5316\u662f\u5143\u4ef6\u53ef\u9884\u6d4b\u5730\u7ec4\u88c5\u7684\u5fc5\u8981\u6761\u4ef6\u3002\u5728\u7ec6\u80de\u95f4\u901a\u8baf\u5de5\u5177\u4e2d\uff0c\u6b63\u4ea4\u5316\u53ef\u4ee5\u786e\u4fdd\u591a\u901a\u9053\u4ea4\u6d41\u4e0d\u76f8\u4e92\u5e72\u6d89\u3002\u201d
\u572810\u4e2a\u5f00\u53d1\u7684\u901a\u8baf\u5de5\u5177\u4e2d\uff0c\u56db\u4e2a\u7ecf\u5178\u7684\u7684QS\u901a\u9053\uff08C4\uff0c3OC6\uff0cC8\u548c3OC12\uff0c\u5728\u9ec4\u6846\u4e2d\u7a81\u51fa\u663e\u793a\uff09\u8868\u73b0\u51fa\u8f83\u660e\u663e\u7684\u4ea4\u53c9\u5e72\u6270\u6027\uff0c\u4f46\u516d\u4e2a\u65b0\u8bbe\u8ba1\u7684\u901a\u9053\uff08\u5728\u7ea2\u6846\u4e2d\u7a81\u51fa\u663e\u793a\uff09\u65e0\u8bba\u662f\u5728\u4fe1\u53f7\u611f\u5e94\u5c42\u9762\u8fd8\u662f\u542f\u52a8\u5b50\u54cd\u5e94\u5c42\u9762\u6709\u663e\u8457\u8f83\u4f4e\u7684\u4ea4\u53c9\u5e72\u6270\u3002\u8fd9\u79cd\u663e\u8457\u7684\u6b63\u4ea4\u6027\u6b63\u662f\u6e90\u4e8e\u8fd9\u4e9b\u4fe1\u53f7\u7cfb\u7edf\u9ad8\u5ea6\u4e0d\u540c\u7684\u7ec4\u6210\u7ed3\u6784\u2014\u2014\u751f\u7269\u5408\u6210\u5c0f\u5206\u5b50\u7684\u5316\u5b66\u591a\u6837\u6027\u548c\u5c0f\u5206\u5b50\u4f20\u611f\u8f6c\u5f55\u56e0\u5b50\u7684\u4e30\u5bcc\u5143\u4ef6\u5e93\u5e26\u6765\u4e86\u5de8\u5927\u7684\u8bbe\u8ba1\u63a2\u7d22\u7a7a\u95f4\u3002

\u901a\u8baf\u5de5\u5177\u5728\u4fe1\u53f7\u611f\u5e94\u5c42\u9762\uff08\u4e0a\uff09\u6216\u8005\u542f\u52a8\u5b50\u54cd\u5e94\uff08\u4e0b\uff09\u5c42\u9762\u7684\u4ea4\u53c9\u5e72\u6270
\u201c\u8fd9\u79cd\u8bbe\u8ba1\u7684\u6210\u529f\u5f3a\u8c03\u4e86\u4e00\u4e2a\u666e\u904d\u7684\u539f\u5219\uff0c\u201d\u6587\u7ae0\u5728\u8ba8\u8bba\u90e8\u5206\u8fdb\u4e00\u6b65\u89e3\u91ca\u9053\uff0c\u201c\u81ea\u7136\u53d1\u751f\u7684\u751f\u5316\u673a\u7406\u5e76\u6ca1\u6709\u63a2\u7d22\u6240\u6709\u53ef\u80fd\u7684\u89e3\u51b3\u65b9\u6848 \u2014\u300c\u591f\u7528\u5c31\u884c\u300d\uff0c\u867d\u7136\u81ea\u7136\u662f\u201c\u5077\u61d2\u201d\u7684\uff0c\u4f46\u662f\u8fd9\u4e3a\u5408\u6210\u751f\u7269\u8bbe\u8ba1\u7559\u4e0b\u4e86\u51e0\u4e4e\u65e0\u9650\u7684\u8bbe\u8ba1\u7a7a\u95f4\u3002\u201d 

\u5408\u6210\u751f\u7269\u5b66\u5c06\u751f\u7269\u7cfb\u7edf\u7684\u7814\u7a76\u62d3\u5c55\u5230\u4e86\u672a\u66fe\u5b58\u5728\u7684\u751f\u547d\u9886\u57df
\uff08\u672c\u56fe\u4fee\u6539\u81eaNature\u8bc4\u8ff0\uff1aBuild life to understand it\uff09<\/p>\n


4.\u9ad8\u6027\u80fd\u7684\u6b63\u4ea4\u6027\u5de5\u5177\u5e26\u6765\u66f4\u590d\u6742\u7684\u7ec6\u80de\u8bbe\u8ba1<\/p>\n

\u76ee\u524d\u5728\u7ec6\u80de\u4e2d\u8fdb\u884c\u590d\u6742\u751f\u7269\u5b66\u8ba1\u7b97\u7684\u5de5\u7a0b\u8fdb\u5c55\u5e76\u4e0d\u987a\u5229\u3002\u8fd9\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u7531\u4e8e\u6211\u4eec\u5bf9\u5927\u578b\u57fa\u56e0\u7ebf\u8def\u7684\u7f16\u7a0b\u80fd\u529b\u975e\u5e38\u6709\u9650\uff1a\u4e0d\u4ec5\u5b58\u5728\u5de5\u5177\u7f3a\u4e4f\u7684\u95ee\u9898\uff0c\u800c\u4e14\u590d\u6742\u57fa\u56e0\u7ebf\u8def\u5728\u7ec6\u80de\u4e2d\u5f88\u5bb9\u6613\u8fc7\u5ea6\u5360\u7528\u7ec6\u80de\u8d44\u6e90\uff0c\u5e76\u4e14\u5728\u8fdb\u5316\u4e0a\u5e76\u4e0d\u7a33\u5b9a\u3002
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\u4e3a\u4e86\u6f14\u793a\u66f4\u590d\u6742\u7684\u591a\u7ec6\u80de\u751f\u7269\u8ba1\u7b97\u529f\u80fd\uff0c\u7814\u7a76\u4eba\u5458\u8bbe\u8ba1\u4e86\u590d\u6742\u7684\u4e09\u8f93\u5165XOR-AND\u903b\u8f91\u95e8\u7535\u8def\u3002XOR-AND\u903b\u8f91\u95e8\u7535\u8def\u5206\u522b\u90e8\u7f72\u5728\u4e03\u4e2a\u4e0d\u540c\u7684\u5927\u80a0\u6746\u83cc\u83cc\u682a\u4e2d\uff0c\u7531\u56db\u4e2a\u901a\u4fe1\u901a\u9053\u534f\u8c03\u3002\u6bcf\u4e2a\u83cc\u682a\u5305\u542b\u4e00\u4e2aNOR\u95e8(cell-1\u81f3cell-6)\u6216\u4e00\u4e2aBuffer\u95e8(cell-7)\u3002\u8fd9\u662f\u5df2\u77e5\u7b2c\u4e00\u4e2a\u540c\u65f6\u5229\u7528\u56db\u4e2a\u901a\u4fe1\u901a\u9053\u7684\u751f\u7269\u8ba1\u7b97\u7ebf\u8def\u3002
XOR-AND\u903b\u8f91\u95e8\u7535\u8def
\u8d75\u4f1a\u4f1f\u5728\u63a5\u53d7\u91c7\u8bbf\u65f6\u8bf4\uff1a\u201c\u901a\u8fc7\u56db\u5957\u7cfb\u7edf\u5171\u7528\uff0c\u6211\u4eec\u5728\u5927\u80a0\u6746\u83cc\u4e2d\u5b9e\u73b0\u300c3 Input-8 Output\u300d\u7684\u57fa\u56e0\u7ebf\u8def\u8bbe\u8ba1\uff0c7\u4e2a\u7ec6\u80de\u4e4b\u95f4\u7684\u751f\u7269\u8ba1\u7b97\u6700\u7ec8\u90fd\u80fd\u8f93\u51fa\u6b63\u786e\u7684\u4fe1\u53f7\uff0c\u8fd9\u662f\u4e00\u4e2a\u4e0d\u5c0f\u7684\u7a81\u7834\u3002\u56e0\u4e3a\u7ec6\u80de\u6ca1\u6709\u7406\u7531\u6309\u7167\u4f60\u7684\u60f3\u6cd5\u5de5\u4f5c\uff0c\u8ba9\u4ed6\u4eec\u5728\u540c\u4e00\u65f6\u7a7a\u4e0b\u534f\u540c\u8d77\u6765\u5de5\u4f5c\uff0c\u8fd8\u662f\u6709\u96be\u5ea6\u7684\u3002\u524d6\u4e2a\u7ec6\u80de\u662fNOR gate\uff0c\u6bcf\u4e2a\u7ec6\u80de\u5fc5\u987b\u6709\u6e05\u6670\u7684ON\/OFF\uff0c\u540c\u65f6\u5c0f\u5206\u5b50\u7684\u751f\u4ea7\u5f3a\u5ea6\u3001\u6269\u6563\u7684\u901f\u7387\u548c\u6d53\u5ea6\u3001\u7ec6\u80de\u95f4\u63a5\u6536\u7684\u901f\u7387\u3001\u54cd\u5e94\u533a\u95f4\u4e0e\u7075\u654f\u5ea6\u7b49\u90fd\u9700\u8981\u7cfb\u7edf\u8003\u8651\u5230\u3002<\/p>\n


5.\u597d\u7684\u7ec6\u80de\u901a\u8baf\u7cfb\u7edf\u80fd\u4e3a\u5408\u6210\u751f\u7269\u5b66\u5e26\u6765\u4ec0\u4e48\uff1f<\/p>\n

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\u8457\u540d\u5408\u6210\u751f\u7269\u5b66\u7814\u7a76\u8005Chris Voigt\u5bf9\u4e8e\u672a\u6765\u5408\u6210\u751f\u7269\u5b66\u53d1\u5c55\u7684\u8bbe\u60f3\uff1a\u672a\u6765\u6211\u4eec\u5c06\u4ece\u5355\u4e2a\u7ec6\u80de\u8f6c\u5230\u7cfb\u7edf\u3002
\u57282030\u5e74\u4e4b\u540e\uff0c\u4ea7\u54c1\u5c06\u8f6c\u5411\u300c\u7cfb\u7edf\u300d\uff0c\u800c\u4e0d\u662f\u5355\u4e2a\u7ec6\u80de\u6216\u8005\u4f53\u7cfb\u3002\u5728\u8fd9\u4e9b\u7cfb\u7edf\u4e2d\uff0c\u7ecf\u8fc7\u8bbe\u8ba1\u7684\u751f\u7269\u7ec6\u80de\u53ef\u4ee5\u4f5c\u4e3a\u7fa4\u4f53\u534f\u540c\u5de5\u4f5c\uff0c\u6216\u8005\u96c6\u6210\u5230\u975e\u751f\u547d\u6750\u6599\u6216\u7535\u5b50\u4ea7\u54c1\u4e4b\u4e2d\u3002\u5728\u519c\u4e1a\u65b9\u9762\uff0c\u5de5\u7a0b\u690d\u7269\u548c\u7ec6\u83cc\u5171\u751f\u7269\u76f8\u4e92\u534f\u540c\uff0c\u4f5c\u4e3a\u4e00\u4e2a\u6574\u4f53\u63a7\u5236\u57fa\u56e0\u8868\u8fbe\u6765\u54cd\u5e94\u4e0d\u540c\u7684\u73af\u5883\u6761\u4ef6\u3002\u672a\u6765\u7684\u6c49\u5821\u8089\u997c\u53ef\u4ee5\u4f7f\u7528\u7ec6\u83cc\u3001\u771f\u83cc\u548c\u7272\u755c\u7ec6\u80de\u7fa4\u4f53\u6765\u751f\u4ea7\uff0c\u5b83\u4eec\u53ef\u4ee5\u5171\u540c\u5efa\u7acb\u590d\u6742\u7684\u7ed3\u6784\u5408\u6210\u5177\u6709\u72ec\u7279\u8425\u517b\u548c\u98ce\u5473\u7684\u5206\u5b50\u3002\u5efa\u7b51\u6750\u6599\u53ef\u4ee5\u5d4c\u5165\u6d3b\u6539\u9020\u7684\u7ec6\u80de\u5b9e\u73b0\u81ea\u6211\u4fee\u590d\u6216\u6e05\u9664\u7a7a\u6c14\u6c61\u67d3\u7684\u529f\u80fd\u3002\u5305\u542b\u5728\u6cb9\u6f06\u603b\u5de5\u7a0b\u751f\u7269\u7cfb\u7edf\u53ef\u4ee5\u9632\u6b62\u8239\u4f53\u751f\u7269\u6c61\u67d3\u3001\u51cf\u5c11\u7ba1\u9053\u8150\u8680\u6d3b\u7740\u7a33\u56fa\u571f\u58e4\u7ed3\u6784\u3002\u5de5\u7a0b\u6d3b\u7ec6\u80de\u4e0e\u7535\u5b50\u8bbe\u5907\u8026\u5408\u4ea7\u751f\u7684\u673a\u5668\u4eba\u53ef\u4ee5\u5229\u7528\u81ea\u7136\u73af\u5883\u4e2d\u7684\u80fd\u91cf\uff0c\u4f7f\u7528\u751f\u7269\u4f20\u611f\u5668\u8fdb\u884c\u5bfc\u822a\u6216\u8005\u5b9e\u73b0\u66f4\u597d\u7684\u8111\u673a\u7ed3\u5408\u3002<\/p>\n


\u590d\u6742\u79d1\u5b66\u6700\u65b0\u8bba\u6587<\/p>\n

\u96c6\u667a\u6591\u56fe\u9876\u520a\u8bba\u6587\u901f\u9012\u680f\u76ee\u4e0a\u7ebf\u4ee5\u6765\uff0c\u6301\u7eed\u6536\u5f55\u6765\u81eaNature\u3001Science\u7b49\u9876\u520a\u7684\u6700\u65b0\u8bba\u6587\uff0c\u8ffd\u8e2a\u590d\u6742\u7cfb\u7edf\u3001\u7f51\u7edc\u79d1\u5b66\u3001\u8ba1\u7b97\u793e\u4f1a\u79d1\u5b66\u7b49\u9886\u57df\u7684\u524d\u6cbf\u8fdb\u5c55\u3002\u73b0\u5728\u6b63\u5f0f\u63a8\u51fa\u8ba2\u9605\u529f\u80fd\uff0c\u6bcf\u5468\u901a\u8fc7\u5fae\u4fe1\u670d\u52a1\u53f7\u300c\u96c6\u667a\u6591\u56fe\u300d\u63a8\u9001\u8bba\u6587\u4fe1\u606f\u3002\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\u5373\u53ef\u4e00\u952e\u8ba2\u9605\uff1a<\/p>\n

<\/div>\n


\u63a8\u8350\u9605\u8bfb
AI\u4e0d\u518d\u9ed1\u7bb1\uff1a\u5229\u7528\u53ef\u89e3\u91ca\u7684\u80f6\u56ca\u7f51\u7edc\u7b97\u6cd5\u8bc6\u522b\u7ec6\u80de\u4e9a\u578b<\/a>\u300aOn Intelligence\u300b\u4f5c\u8005Jeff Hawkins\u9996\u63d0\u201c\u5343\u8111\u667a\u80fd\u7406\u8bba\u201d\uff0c\u7834\u89e3\u76ae\u5c42\u7f51\u683c\u7ec6\u80de\u8c1c\u9898<\/a>
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