{"id":23295,"date":"2021-01-17T23:59:09","date_gmt":"2021-01-17T15:59:09","guid":{"rendered":"https:\/\/swarma.org\/?p=23295"},"modified":"2021-01-17T23:59:09","modified_gmt":"2021-01-17T15:59:09","slug":"prx%e7%94%9f%e7%89%a9%e7%89%a9%e7%90%86%e5%89%8d%e6%b2%bf%ef%bc%9a%e5%99%aa%e5%a3%b0%e9%a9%b1%e5%8a%a8%e7%9a%84%e7%bb%86%e8%83%9e%e4%b8%8d%e5%90%8c%e7%8a%b6%e6%80%81%e8%b7%b3%e8%bd%ac%e7%9a%84","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=23295","title":{"rendered":"PRX\u751f\u7269\u7269\u7406\u524d\u6cbf\uff1a\u566a\u58f0\u9a71\u52a8\u7684\u7ec6\u80de\u4e0d\u540c\u72b6\u6001\u8df3\u8f6c\u7684\u52a8\u529b\u5b66\u673a\u7406"},"content":{"rendered":"
<\/p>\n

\u5bfc\u8bed<\/p>\n

\u7ec6\u80de\u751f\u6d3b\u5728\u4e0d\u65ad\u53d8\u5316\u7684\u590d\u6742\u73af\u5883\u4e2d\uff0c\u901a\u8fc7\u4fe1\u53f7\u8f6c\u5bfc\u901a\u8def\u4f20\u9012\u5916\u90e8\u7684\u4fe1\u53f7\u548c\u523a\u6fc0\u5230\u7ec6\u80de\u5185\u7684\u8c03\u63a7\u7f51\u7edc\u30022021\u5e741\u67087\u65e5\uff0c\u5317\u4eac\u5927\u5b66\u7269\u7406\u5b66\u9662\/\u5b9a\u91cf\u751f\u7269\u5b66\u4e2d\u5fc3\u674e\u65b9\u5ef7\u3001\u6b27\u9633\u9880\u751f\u7269\u7269\u7406\u56e2\u961f\u4e0e\u5317\u5927\u6570\u5b66\u5b66\u9662\u674e\u94c1\u519b\u8bfe\u9898\u7ec4\u4ee5\u53ca\u4e2d\u56fd\u519c\u4e1a\u5927\u5b66\u697c\u6167\u5f3a\u8bfe\u9898\u7ec4\u5408\u4f5c\uff0c\u5728Physical Review X\u6742\u5fd7\u53d1\u8868\u540d\u4e3a\u201cStochasticity triggers activation of the S-phase checkpoint pathway in budding yeast\u201d\u7684\u6587\u7ae0\uff0c\u901a\u8fc7\u9175\u6bcd\u83cc\u7684\u5355\u7ec6\u80de\u65f6\u5e8f\u6570\u636e\uff0c\u63d0\u4f9b\u4e86\u566a\u58f0\u9a71\u52a8\u7ec6\u80de\u5728\u4e0d\u540c\u72b6\u6001\u4e4b\u95f4\u8df3\u8f6c\u7684\u76f4\u63a5\u8bc1\u636e\uff0c\u63ed\u793a\u4e86\u566a\u58f0\u5728\u4fe1\u53f7\u8f6c\u5bfc\u901a\u8def\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n

\u9ad8\u946b | \u4f5c\u8005
\u9093\u4e00\u96ea | \u7f16\u8f91<\/p>\n


\u8bba\u6587\u9898\u76ee\uff1a
Stochasticity triggers activation of the S-phase checkpoint pathway in budding yeast
\u8bba\u6587\u5730\u5740\uff1a
https:\/\/journals.aps.org\/prx\/abstract\/10.1103\/PhysRevX.11.011004<\/p>\n

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\u5317\u4eac\u5927\u5b66\u674e\u65b9\u5ef7\u3001\u674e\u94c1\u519b\u548c\u4e2d\u56fd\u519c\u4e1a\u5927\u5b66\u697c\u6167\u5f3a\u4e3a\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002\u5317\u4eac\u5927\u5b66\u5468\u6c9b\u52bc\u3001\u9ad8\u946b\u548c\u4e2d\u56fd\u519c\u4e1a\u5927\u5b66\u674e\u6653\u4e3d\u4e3a\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3002\u8be5\u7814\u7a76\u5f97\u5230\u4e86\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u3001\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u5317\u4eac\u667a\u6e90\u4eba\u5de5\u667a\u80fd\u7814\u7a76\u9662\u7b49\u673a\u6784\u7684\u652f\u6301\u3002<\/p>\n

\u53c2\u8003\u6587\u732e
Elowitz, M. B., Levine, A. J., Siggia, E. D., & Swain, P. S. (2002). Stochastic gene expression in a single cell. Science, 297(5584), 1183-1186.Raser, J. M., & O’Shea, E. K. (2004). Control of stochasticity in eukaryotic gene expression. science, 304(5678), 1811-1814.Acar, M., Becskei, A., & van Oudenaarden, A. (2005). Enhancement of cellular memory by reducing stochastic transitions. Nature, 435(7039), 228-232.Choi, P. J., Cai, L., Frieda, K., & Xie, X. S. (2008). A stochastic single-molecule event triggers phenotype switching of a bacterial cell. Science, 322(5900), 442-446.<\/p>\n


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