{"id":23384,"date":"2021-01-20T19:45:22","date_gmt":"2021-01-20T11:45:22","guid":{"rendered":"https:\/\/swarma.org\/?p=23384"},"modified":"2021-01-20T19:45:22","modified_gmt":"2021-01-20T11:45:22","slug":"%e4%bd%9c%e4%b8%ba%e5%9b%a0%e6%9e%9c%e7%a7%91%e5%ad%a6%e5%ae%b6%e7%9a%84%e7%a5%9e%e7%bb%8f%e7%b3%bb%e7%bb%9f%ef%bc%9a%e5%9b%a0%e6%9e%9c%e7%bc%96%e7%a0%81","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=23384","title":{"rendered":"\u4f5c\u4e3a\u56e0\u679c\u79d1\u5b66\u5bb6\u7684\u795e\u7ecf\u7cfb\u7edf\uff1a\u56e0\u679c\u7f16\u7801"},"content":{"rendered":"
<\/p>\n

\u5bfc\u8bed<\/p>\n

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\u7530\u6d0b | \u4f5c\u8005
\u9093\u4e00\u96ea | \u7f16\u8f91<\/p>\n

1. \u56e0\u679c\u7f16\u7801\u7814\u7a76\uff1a\u8fdb\u5c55\u4e0e\u6311\u6218<\/p>\n

\u56e0\u679c\u5173\u7cfb\u5e38\u88ab\u8ba4\u4e3a\u662f\u6700\u96be\u5224\u5b9a\u7684\u5173\u7cfb\u4e4b\u4e00\uff0c\u4ece\u6570\u5b66\u548c\u7edf\u8ba1\u5b66\u89d2\u5ea6\u51c6\u786e\u5224\u65ad\u4e0d\u540c\u4fe1\u606f\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u4e00\u76f4\u662f\u516c\u5f00\u7684\u6311\u6218\u3002\u7136\u800c\uff0c\u5927\u8111\u4e2d\u7684\u56e0\u679c\u5173\u7cfb\u5374\u4e0d\u90a3\u4e48\u201c\u9ad8\u4e0d\u53ef\u6500\u201d\uff0c\u5b83\u201c\u4eb2\u548c\u201d\u5730\u53c2\u4e0e\u4e86\u51e0\u4e4e\u6240\u6709\u57fa\u7840\u7684\u611f\u77e5\u89c9\u548c\u8ba4\u77e5\u8fc7\u7a0b[1]\u3002\u4eba\u7c7b\u5bf9\u5916\u754c\u7684\u611f\u77e5\u4e0d\u53ef\u907f\u514d\u5730\u4f34\u968f\u7740\u5bf9\u591a\u4e2a\u523a\u6fc0\u7684\u52a0\u5de5\u3002\u5728\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\uff0c\u4e0d\u540c\u523a\u6fc0\u53ef\u4ee5\u88ab\u89c6\u4e3a\u6563\u843d\u4e8e\u5916\u754c\u7684\u8282\u70b9\uff0c\u800c\u523a\u6fc0\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u5219\u6784\u6210\u4e86\u4eba\u7c7b\u6240\u611f\u77e5\u5230\u7684\u5916\u754c\u7684\u9aa8\u67b6\u3002\u4eba\u7c7b\u7684\u611f\u77e5\u89c9\u6b63\u662f\u7531\u5bf9\u591a\u4e2a\u523a\u6fc0\u8fdb\u884c\u7f16\u7801\u3001\u96c6\u6210\u7684\u8fc7\u7a0b[2-4]\u548c\u5bf9\u523a\u6fc0\u95f4\u56e0\u679c\u5173\u7cfb\u8fdb\u884c\u8868\u5f81\u7684\u8fc7\u7a0b[3]\u5171\u540c\u7ec4\u6210\u7684[2,5,6]\u3002<\/p>\n

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\u4e3a\u4e86\u68c0\u9a8c\u4e0a\u8ff0\u63a8\u6d4b\u7684\u5408\u7406\u6027\uff0c\u6765\u81ea\u6e05\u534e\u5927\u5b66\u5fc3\u7406\u5b66\u7cfb&\u6e05\u534e\u5927\u5b66\u8111\u4e0e\u667a\u80fd\u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u56e2\u961f\u8fdb\u884c\u4e86\u4e00\u9879\u63a2\u7d22\u6027\u7814\u7a76\uff0c\u8bc1\u660e\u4e86\u57fa\u7840\u7684\u795e\u7ecf\u52a8\u529b\u5b66\u4f1a\u81ea\u53d1\u5730\u5b8c\u6210\u5bf9\u5916\u754c\u56e0\u679c\u5173\u7cfb\u7684\u8868\u5f81\u3002\u8be5\u7814\u7a76\u7684\u90e8\u5206\u7ed3\u679c\u4e8e2021\u5e741\u670812\u65e5\u53d1\u8868\u5728 Physical Review E\u3002
\u8bba\u6587\u6807\u9898\uff1aCharacteristics of the neural coding of causality\u8bba\u6587\u5730\u5740\uff1ahttps:\/\/journals.aps.org\/pre\/abstract\/10.1103\/PhysRevE.103.012406 <\/p>\n


2. \u57fa\u7840\u7684\u56e0\u679c\u7f16\u7801\u2014\u2014\u4ece\u795e\u7ecf\u5143\u52a8\u529b\u5b66\u5f00\u59cb<\/p>\n

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\u88ab\u79f0\u4e3ainput neuron\u7684\u795e\u7ecf\u5143\u66f4\u4e3a\u76f4\u63a5\u5730\u63a5\u6536\u5230\u523a\u6fc0\uff0c\u5176\u795e\u7ecf\u6d3b\u52a8\u66f4\u591a\u5730\u53d7\u5230\u523a\u6fc0\u672c\u8eab\u7684\u5f71\u54cd\u3002\u5728\u771f\u5b9e\u60c5\u666f\u4e2d\uff0c\u795e\u7ecf\u5143\u5bf9\u5916\u754c\u523a\u6fc0\u662f\u6709\u9009\u62e9\u6027\u7684\uff08\u88ab\u79f0\u4e3aneural tuning property\uff09\uff0c\u4efb\u610f\u795e\u7ecf\u5143\u5e76\u4e0d\u4f1a\u65e0\u5dee\u522b\u5730\u5bf9\u6240\u6709\u523a\u6fc0\u90fd\u54cd\u5e94\u3002\u7814\u7a76\u8005\u6ca1\u6709\u7b80\u5316\u8fd9\u4e00\u7279\u6027\uff0c\u800c\u91c7\u7528\u4e86\u795e\u7ecf\u79d1\u5b66\u4e2d\u901a\u7528\u7684neural tuning curve\uff08\u4e00\u79cd\u63cf\u8ff0\u795e\u7ecf\u5143\u5bf9\u7279\u5b9a\u523a\u6fc0\u54cd\u5e94\u5f3a\u5ea6\u7684\u66f2\u7ebf\uff09\u6765\u523b\u753b\u4e0a\u8ff0\u9009\u62e9\u6027\u3002\u5728\u5b9e\u9a8c\u4e2d\uff0c\u6bcf\u4e2ainput neuron\u90fd\u6709\u4e00\u4e2a\u968f\u673a\u751f\u6210\u7684neural tuning curve\u3002\u800c\u540e\uff0c\u7814\u7a76\u8005\u5b9a\u4e49\u4e86\u4e00\u4e2a\u975e\u9f50\u6b21\u6cca\u677e\u8fc7\u7a0b\u7528\u4e8e\u63cf\u8ff0\u4efb\u610finput neuron\u5728\u7279\u5b9a\u65f6\u6bb5\u5185\u63a5\u6536\u5230\u4e00\u4e2a\u968f\u673a\u751f\u6210\u7684\u523a\u6fc0\u5e8f\u5217\u800c\u4ea7\u751f\u7684\u795e\u7ecf\u5143\u6d3b\u52a8\u3002\u88ab\u79f0\u4e3aintermediary neuron\u7684\u795e\u7ecf\u5143\u5728\u63a5\u6536\u523a\u6fc0\u7684\u8fc7\u7a0b\u4e2d\u53d7\u5230\u4e86\u590d\u6742\u7684\u7f51\u7edc\u52a8\u529b\u5b66\u7684\u5f71\u54cd\uff0c\u5176\u795e\u7ecf\u6d3b\u52a8\u4e0d\u80fd\u88ab\u8ba4\u4e3a\u662f\u72ec\u7acb\u7684\u3002\u4e0d\u540c\u795e\u7ecf\u5143\u95f4\u5b58\u5728\u590d\u6742\u7684\u4e92\u52a8\u5173\u7cfb\uff0c\u5e76\u4e0d\u80fd\u88ab\u7701\u7565\uff0c\u8fd9\u7ed9\u63cf\u8ff0\u795e\u7ecf\u5143\u6d3b\u52a8\u5e26\u6765\u4e86\u6781\u5927\u7684\u6311\u6218\u3002\u7814\u7a76\u8005\u5de7\u5999\u5730\u53d1\u5c55\u4e86\u4e00\u5957\u534a\u968f\u673a\u5316\u7684\u65b9\u6cd5\u83b7\u5f97\u4e86intermediary neuron\u7684\u795e\u7ecf\u6d3b\u52a8\u6570\u636e\uff0c\u518d\u57fa\u4e8e\u6700\u5927\u4f3c\u7136\u4f30\u8ba1\u8fd8\u539f\u51fa\u6570\u636e\u5e94\u8be5\u7b26\u5408\u7684\u975e\u9f50\u6b21\u6cca\u677e\u8fc7\u7a0b\uff0c\u4ece\u800c\u5b8c\u6210\u4e86\u795e\u7ecf\u6d3b\u52a8\u7684\u63cf\u8ff0\u3002
\u603b\u4e4b\uff0c\u5728\u751f\u6210\u795e\u7ecf\u5143\u7684\u7fa4\u4f53\u52a8\u529b\u5b66\u7684\u8fc7\u7a0b\u4e2d\uff0c\u7814\u7a76\u8005\u5e76\u6ca1\u6709\u6dfb\u52a0\u7b80\u5316\u6761\u4ef6\uff0c\u800c\u662f\u53d1\u5c55\u4e86\u4e00\u5957\u5408\u7406\u7684\u6570\u5b66\u6846\u67b6\u63cf\u8ff0\u4e86\u57fa\u7840\u7684\u795e\u7ecf\u7cfb\u7edf\u8981\u7d20\uff0c\u751f\u6210\u4e86\u76f8\u5bf9\u7b26\u5408\u5b9e\u9645\u7684\u795e\u7ecf\u5143\u6d3b\u52a8\u3002                   <\/p>\n

3. \u57fa\u7840\u7684\u56e0\u679c\u7f16\u7801\uff1a
\u795e\u7ecf\u52a8\u529b\u5b66\u5bf9\u56e0\u679c\u7684\u8868\u5f81<\/p>\n



\u5728\u751f\u6210\u4e86\u968f\u673a\u7684\u523a\u6fc0\u5e8f\u5217\u4ee5\u53ca\u523a\u6fc0\u8bf1\u53d1\u7684\u795e\u7ecf\u52a8\u529b\u5b66\u540e\uff0c\u7814\u7a76\u8005\u5f00\u59cb\u8fdb\u884c\u56e0\u679c\u5ea6\u91cf\u3002\u4e3a\u4e86\u4fdd\u8bc1\u4e00\u822c\u6027\uff0c\u7814\u7a76\u8005\u4f7f\u7528\u4e863\u79cd\u4e0d\u540c\u7684\u56e0\u679c\u5ea6\u91cf\u65b9\u6cd5\uff0c\u5206\u522b\u8bb0\u4e3aLG (Lasso-Ganger \u65b9\u6cd5[14])\u3001CG\uff08copula-Lasso-Granger \u65b9\u6cd5[15]\uff09\u548cTE\uff08transfer entropy \u65b9\u6cd5[16]\uff09\u3002\u9996\u5148\uff0c\u7814\u7a76\u8005\u5148\u751f\u6210\u591a\u4e2a\u968f\u673a\u7684\u523a\u6fc0\u5e8f\u5217\uff0c\u5e76\u5ea6\u91cf\u4efb\u610f\u4e24\u4e2a\u523a\u6fc0\u5e8f\u5217\u95f4\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u8fd9\u8868\u5f81\u4e86\u5916\u754c\u523a\u6fc0\u539f\u672c\u7684\u56e0\u679c\u6027\uff08original causal relation\uff09\u3002\u7814\u7a76\u8005\u8fdb\u4e00\u6b65\u751f\u6210\u4e86\u591a\u4e2a\u523a\u6fc0\u95f4\u539f\u59cb\u7684\u56e0\u679c\u5173\u7cfb\u56fe\uff08original causality graph\uff09\u3002\u800c\u540e\uff0c\u7814\u7a76\u8005\u5ea6\u91cf\u4e86\u4e0d\u540c\u523a\u6fc0\u5bf9\u5e94\u7684\u795e\u7ecf\u5143\u96c6\u7fa4\u6d3b\u52a8\uff08neural population codes\uff09\u95f4\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u5373\u795e\u7ecf\u7cfb\u7edf\u5185\u90e8\u7f16\u7801\u540e\u7684\u523a\u6fc0\u4fe1\u606f\u95f4\u6240\u5177\u5907\u7684\u56e0\u679c\u6027\uff08coded causal relation\uff09\uff0c\u5e76\u57fa\u4e8e\u6b64\u751f\u6210\u4e86\u591a\u4e2a\u523a\u6fc0\u5728\u7f16\u7801\u540e\u5f62\u6210\u7684\u56e0\u679c\u5173\u7cfb\u56fe\uff08coded causality graph\uff09\u3002\u56fe1\u662f\u4e00\u4e2a\u5177\u4f53\u7684\u793a\u4f8b\u3002<\/p>\n

\u56fe1. \u795e\u7ecf\u7f16\u7801\u524d\u548c\u795e\u7ecf\u7f16\u7801\u540e\u7684\u523a\u6fc0\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002
\u663e\u7136\uff0c\u5982\u679c\u80fd\u591f\u68c0\u9a8c\u539f\u672c\u7684\u56e0\u679c\u5173\u7cfb\uff08original causal relation\u548coriginal causality graph\uff09\u548c\u7f16\u7801\u540e\u7684\u56e0\u679c\u5173\u7cfb\uff08coded causal relation\u548ccoded causality graph\uff09\u95f4\u7684\u76f8\u4f3c\u6027\uff0c\u90a3\u5c31\u80fd\u591f\u9a8c\u8bc1\u795e\u7ecf\u52a8\u529b\u5b66\u662f\u5426\u80fd\u652f\u6491\u57fa\u7840\u7684\u56e0\u679c\u7f16\u7801\u8fc7\u7a0b\u3002\u7814\u7a76\u8005\u8fdb\u884c\u4e86\u591a\u6b21\u5927\u89c4\u6a21\u7684\u968f\u673a\u5b9e\u9a8c\uff0c\u5bf9\u8fd9\u4e00\u95ee\u9898\u7ed9\u51fa\u4e86\u80af\u5b9a\u7684\u7b54\u6848\u3002
\u5728\u7ed9\u51fa\u6700\u7ec8\u7b54\u6848\u524d\uff0c\u7814\u7a76\u8005\u9996\u5148\u5206\u6790\u4e86\u795e\u7ecf\u7f16\u7801\u8fc7\u7a0b\u4f1a\u5bf9\u56e0\u679c\u5173\u7cfb\u9020\u6210\u4ec0\u4e48\u6837\u7684\u5f71\u54cd\uff08coding effects\uff09\u3002\u7814\u7a76\u8005\u53d1\u73b0\u7f16\u7801\u524d\u540e\u56e0\u679c\u5173\u7cfb\u7684\u5dee\u5f02\u503c\u4e0e\u539f\u59cb\u56e0\u679c\u5173\u7cfb\u7684\u503c\u5448\u73b0\u51fa\u4e00\u5b9a\u7684\u7ebf\u6027\u5173\u7cfb\uff0c\u8fd9\u610f\u5473\u7740\u5916\u754c\u523a\u6fc0\u95f4\u539f\u59cb\u7684\u56e0\u679c\u5173\u7cfb\u7684\u786e\u5bf9\u56e0\u679c\u7f16\u7801\u8fc7\u7a0b\u6709\u663e\u8457\u5f71\u54cd\uff08\u89c1\u56fe2a\uff09\u3002\u5982\u679c\u5c06\u7f16\u7801\u524d\u540e\u7684\u56e0\u679c\u56fe\u8fdb\u884c\u5339\u914d\uff0c\u5e76\u8ba1\u7b97\u771f\u9633\u6027\uff08TP\uff09\u3001\u5047\u9634\u6027\uff08FN\uff09\u3001\u771f\u9634\u6027\uff08TN\uff09\u548c\u5047\u9633\u6027\uff08TP\uff09\uff0c\u7814\u7a76\u8005\u53d1\u73b0\u795e\u7ecf\u52a8\u529b\u5b66\u80fd\u4ee5\u76f8\u5bf9\u53ef\u63a5\u53d7\u7684\u771f\u9633\u6027\u548c\u771f\u9634\u6027\u7387\u7f16\u7801\u56e0\u679c\u5173\u7cfb\u56fe\uff08\u89c1\u56fe2b\uff09\u3002\u540c\u65f6\uff0c\u7f16\u7801\u540e\u7684\u56e0\u679c\u5173\u7cfb\u7684\u5206\u5e03\u76f8\u5bf9\u7f16\u7801\u524d\u7684\u56e0\u679c\u5173\u7cfb\u7684\u5206\u5e03\u66f4\u4e3a\u7a00\u758f\uff0c\u4e0d\u540c\u56e0\u679c\u5173\u7cfb\u95f4\u7684\u5dee\u5f02\u88ab\u653e\u5927\uff0c\u8fd9\u610f\u5473\u7740\u795e\u7ecf\u52a8\u529b\u5b66\u5728\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u63d0\u4f9b\u4e86\u56e0\u679c\u5173\u7cfb\u7684\u7a00\u758f\u6027\u7f16\u7801\uff08\u89c1\u56fe2c\uff09\u3002
     \u56fe2. \u795e\u7ecf\u7f16\u7801\u8fc7\u7a0b\u5bf9\u56e0\u679c\u5173\u7cfb\u9020\u6210\u7684\u5f71\u54cd\u3002
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4. \u603b\u7ed3<\/p>\n

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[26] A. Katchalsky and O. Kedem, Thermodynamics of flow processes in biological systems, Biophys. J. 2, 53 (1962).
[27] H. Qian and T. C. Reluga, Nonequilibrium Thermodynamics and Nonlinear Kinetics in a Cellular Signaling Switch, Phys. Rev. Lett. 94, 028101 (2005).
[28] D. T. Haynie, Biological Thermodynamics (Cambridge University, Cambridge, England, 2001).
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