{"id":23940,"date":"2021-02-20T15:57:15","date_gmt":"2021-02-20T07:57:15","guid":{"rendered":"https:\/\/swarma.org\/?p=23940"},"modified":"2021-02-20T15:57:15","modified_gmt":"2021-02-20T07:57:15","slug":"%e5%b7%b4%e6%8b%89%e5%b7%b4%e8%a5%bf-nature-%e5%88%8a%e6%96%87%ef%bc%9a%e4%ba%ba%e7%b1%bb%e5%9f%ba%e5%9b%a0%e7%bb%84%e8%ae%a1%e5%88%9220%e5%b9%b4%ef%bc%8c-%e6%98%8e%e6%98%9f%e5%9f%ba%e5%9b%a0%e5%a4%a7","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=23940","title":{"rendered":"\u5df4\u62c9\u5df4\u897f Nature \u520a\u6587\uff1a\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u521220\u5e74\uff0c \u660e\u661f\u57fa\u56e0\u5927\u653e\u5f02\u5f69\uff0c\u751f\u7269\u7f51\u7edc\u4e9f\u5f85\u63a2\u7d22"},"content":{"rendered":"<div class='wxsyncmain'>                                                                                                          <img loading=\"lazy\" data-ratio=\"0.7566666666666667\"  data-type=\"png\" data-w=\"600\" height=\"auto\" style=\"white-space: normal;width: 100%;height: auto;\" width=\"600\" data-backw=\"600\" data-backh=\"454\" src=\"\/wp-content\/uploads\/2021\/02\/wxsync-2021-02-7d41f711b48fa5eb1dce4666ce1d26a9.png\"  \/><\/p>\n<p>\u5bfc\u8bed<\/p>\n<p>\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\uff08Human Genome Project, HGP\uff09\u662f\u4e00\u9879\u89c4\u6a21\u5b8f\u5927\u3001\u8de8\u56fd\u8de8\u5b66\u79d1\u7684\u79d1\u5b66\u63a2\u7d22\u5de5\u7a0b\u3002\u5176\u5b97\u65e8\u5728\u4e8e\u6d4b\u5b9a\u7ec4\u6210\u4eba\u7c7b\u67d3\u8272\u4f53\uff08\u6307\u5355\u500d\u4f53\uff09\u4e2d\u6240\u5305\u542b\u7684\u753130\u4ebf\u4e2a\u78b1\u57fa\u5bf9\u6240\u7ec4\u6210\u7684\u6838\u82f7\u9178\u5e8f\u5217\uff0c\u4ece\u800c\u7ed8\u5236\u4eba\u7c7b\u57fa\u56e0\u7ec4\u56fe\u8c31\u3001\u8fa8\u8bc6\u5176\u8f7d\u6709\u7684\u57fa\u56e0\u53ca\u5176\u5e8f\u5217\uff0c\u8fbe\u5230\u7834\u8bd1\u4eba\u7c7b\u9057\u4f20\u4fe1\u606f\u7684\u6700\u7ec8\u76ee\u7684\u30022021\u5e742\u670811\u65e5\uff0c\u5728\u4eba\u7c7b\u57fa\u56e0\u7ec4\u56fe\u8c31\u53d1\u5e0320\u5468\u5e74\u4e4b\u9645\uff0cNature\u520a\u767b\u7684\u4e00\u7bc7\u7f51\u7edc\u79d1\u5b66\u5b66\u8005Albert-L\u00e1szl\u00f3 Barab\u00e1si\u7b49\u4eba\u7684\u8bc4\u8bba\u6587\u7ae0\uff0c\u5206\u6790\u4e86\u81ea2001\u5e74\u4ee5\u6765\u57fa\u56e0\u7ec4\u7814\u7a76\u9886\u57df\u7684\u53d1\u8868\u520a\u7269\u3001\u7814\u53d1\u836f\u7269\u4e0e\u4eba\u7c7b\u75be\u75c5\u7684\u5f71\u54cd\u5173\u7cfb\uff0c\u65e8\u5728\u4e3a\u672a\u6765\u57fa\u56e0\u7ec4\u7814\u7a76\u63d0\u4f9b\u65b0\u7684\u89c6\u89d2\u3002<br \/><img data-type=\"png\" data-ratio=\"0.07314814814814814\" data-w=\"1080\"  style=\"box-sizing: border-box;vertical-align: middle;visibility: visible !important;width: 677px !important;\" src=\"\/wp-content\/uploads\/2021\/02\/wxsync-2021-02-e16cd5b776e38a4f6806c73548bdc7d4.png\"  \/>Alexander J. Gates, Deisy Morselli Gysi, Manolis Kellis, Albert-L\u00e1szl\u00f3 Barab\u00e1si&nbsp;| \u4f5c\u8005<br \/>\u80e1\u4e00\u51b0&nbsp;|&nbsp;\u8bd1\u8005<br \/>\u8d75\u96e8\u4ead\u3001\u5218\u57f9\u6e90&nbsp;|&nbsp;\u5ba1\u6821<\/p>\n<p>\u9093\u4e00\u96ea&nbsp;|&nbsp;\u7f16\u8f91<\/p>\n<p>1. \u57fa\u56e0\u7ec4\u8ba1\u5212\u7814\u7a76\u8d8b\u52bf<\/p>\n<p>\u4eba\u7c7b\u57fa\u56e0\u7ec4\u56fe\u8c31\u7b2c\u4e00\u7248[1,2]\u53d1\u886820\u5468\u5e74\u662f\u4e00\u4e2a\u5951\u673a\uff0c\u8ba9\u6211\u4eec\u80fd\u56de\u6eaf\u8be5\u9879\u76ee\u5982\u4f55\u4fc3\u8fdb\u4e86\u4eba\u7c7b\u75be\u75c5\u7684\u57fa\u56e0\u6839\u6e90\u7814\u7a76\u3001\u5982\u4f55\u6539\u53d8\u4e86\u836f\u7269\u7814\u53d1\u4ee5\u53ca\u5982\u4f55\u534f\u52a9\u4fee\u6b63\u6211\u4eec\u5bf9\u57fa\u56e0\u672c\u8eab\u7684\u7406\u89e3\u3002&nbsp;\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u6839\u636e\u73b0\u6709\u8d44\u6599\u9884\u6d4b\u5173\u4e8e\u4eba\u7c7b\u57fa\u56e0\u7ec4\u672a\u6765\u7814\u7a76\u7684\u5f71\u54cd\u548c\u8d8b\u52bf\u3002\u7814\u7a76\u8005\u4eec\u7ed3\u5408\u591a\u4e2a\u6570\u636e\u96c6\u6765\u91cf\u5316\u5df2\u7ecf\u53d1\u73b0\u5e76\u88ab\u53d1\u8868\u7684\u4e0d\u540c\u7c7b\u578b\u7684\u9057\u4f20\u56e0\u7d20\uff08genetic element\uff09\uff1b\u4ee5\u53ca\u8fd9\u4e9b\u5e74\u6765\uff0c\u53d1\u73b0\u548c\u53d1\u8868\u7684\u6a21\u5f0f\u662f\u5982\u4f55\u53d8\u5316\u7684\u3002\u5206\u6790\u5229\u7528\u7684\u6570\u636e\u5177\u4f53\u5305\u62ec38546\u4e2aRNA\u8f6c\u5f55\u7269\uff08transcripts\uff09\u3001\u7ea6100\u4e07\u4e2a\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff08Single Nucleotide Polymorphisms, SNPs\uff09\u30011660\u79cd\u6709\u8bb0\u8f7d\u7684\u53d7\u9057\u4f20\u5f71\u54cd\u7684\u4eba\u7c7b\u75be\u75c5\u30017712\u79cd\u5df2\u6279\u51c6\u548c\u8bd5\u9a8c\u7684\u836f\u7269\u548c704515\u7bc71900\u81f32017\u5e74\u95f4\u7684\u79d1\u7814\u8457\u4f5c\u3002&nbsp;<img class=\"rich_pages\" data-ratio=\"0.6490134994807892\" data-s=\"300,640\"  data-type=\"png\" data-w=\"963\" style=\"\" src=\"\/wp-content\/uploads\/2021\/02\/wxsync-2021-02-f963d5ca99d5a0acce51e406b4d3dc61.png\"  \/>\u56fe1. Nature\u548cScience\u4e3a\u7eaa\u5ff5HGP20\u5468\u5e74\u7684\u7279\u522b\u5c01\u9762<br  \/>&nbsp;\u7814\u7a76\u7ed3\u679c\u5f3a\u8c03\u4e86\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\uff08Human Genome Project , HGP\uff09\u53ca\u5176\u5168\u9762\u7684\u86cb\u767d\u8d28\u7f16\u7801\u57fa\u56e0\u6e05\u5355\u5982\u4f55\u5f00\u8f9f\u5c55\u793a\u57fa\u56e0\u7ec4\u975e\u7f16\u7801\u90e8\u5206\u529f\u80fd\u7684\u65b0\u65f6\u4ee3\uff0c\u5e76\u4e3a\u672a\u6765\u7684\u533b\u836f\u5f00\u53d1\u94fa\u5e73\u9053\u8def\u3002\u5173\u952e\u7684\u662f\uff0c\u7814\u7a76\u4eba\u5458\u7ed8\u5236\u4e9a\u7ec6\u80de\u7ed3\u6784\uff08cellular building blocks\uff09\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u56fe\u65f6\uff0c\u7814\u7a76\u7ed3\u679c\u53ef\u8ffd\u6eaf\u5230\u751f\u7269\u5b66\u7cfb\u7edf\u5c42\u89c6\u56fe\u4e0e\u4f20\u7edf\u5355\u57fa\u56e0\u89c6\u56fe\u7684\u51fa\u73b0\u3002&nbsp;\u672c\u9879\u5206\u6790\u4e5f\u5b58\u5728\u5c40\u9650\u6027\u3002\u4f8b\u5982\uff0c\u5b66\u754c\u5bf9\u90e8\u5206\u57fa\u56e0\u7684\u8d77\u59cb\u4f4d\u70b9\u3001\u7ec8\u6b62\u4f4d\u70b9\uff0c\u751a\u81f3\u662f\u67d0\u4e9b\u57fa\u56e0\u7684\u786e\u5207\u7f16\u7801\u5e8f\u5217\u90fd\u6ca1\u6709\u8fbe\u6210\u5171\u8bc6[3]\u3002\u4e00\u4e9b\u57fa\u56e0\u5143\u4ef6\u4f7f\u7528\u591a\u79cd\u547d\u540d\u89c4\u5219\uff0c\u56e0\u6b64\u6709\u65f6\u7814\u7a76\u4eba\u5458\u65e0\u6cd5\u5c06\u5b83\u4eec\u7edf\u4e00\u8d77\u6765\u3002\u6b64\u5916\uff0c\u6709\u4e9b\u4f5c\u8005\u6ca1\u6709\u5c06\u5b66\u672f\u8457\u4f5c\u548c\u57fa\u56e0\u5e8f\u5217\u4e4b\u95f4\u7684\u8054\u7cfb\u6dfb\u52a0\u5230\u6570\u636e\u5e93\u4e2d\u3002\u6700\u540e\uff0c\u8003\u8651\u5230\u6587\u7ae0\u7684\u53d1\u8868\u548c\u8fdb\u5165\u6211\u4eec\u4f7f\u7528\u7684\u6570\u636e\u5e93\u4e4b\u95f4\u53ef\u80fd\u4f1a\u5b58\u5728\u65f6\u95f4\u5dee\uff0c\u6211\u4eec\u7528\u6765\u6784\u9020\u76f8\u4e92\u4f5c\u7528\u56fe\u8868\u7684\u6570\u636e\u622a\u6b62\u4e8e2017\u5e74\u3002&nbsp;<iframe class=\"video_iframe rich_pages\" data-vidtype=\"2\" data-mpvid=\"wxv_1747129724679536654\" data-cover=\"http%3A%2F%2Fmmbiz.qpic.cn%2Fmmbiz_jpg%2FwibWV1DB7tWJibo19UiaicMb3raH89JS3Wt6pIQblGZI6gom3Tyiafeic8alPyPibILPbyhbTnXA7Fh9PypjrclsrRicOA%2F0%3Fwx_fmt%3Djpeg\" allowfullscreen=\"\" frameborder=\"0\" data-ratio=\"1.7777777777777777\" data-w=\"1280\"  src=\"https:\/\/mp.weixin.qq.com\/mp\/readtemplate?t=pages\/video_player_tmpl&amp;action=mpvideo&amp;auto=0&amp;vid=wxv_1747129724679536654\" width=\"100%\" height=\"720\"><\/iframe>\u89c6\u9891\uff1a\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u521220\u5e74\u7814\u7a76\u5206\u6790\u7684\u53ef\u89c6\u5316<\/p>\n<p>\u7136\u800c\uff0c\u6211\u4eec\u5e76\u4e0d\u8ba4\u4e3a\u8fd9\u4e9b\u95ee\u9898\u4f1a\u5f71\u54cd\u6211\u4eec\u5728\u57fa\u56e0\u7ec4\u8ba1\u5212\u7814\u7a76\u4e2d\u6240\u53d1\u73b0\u7684\u6574\u4f53\u8d8b\u52bf\u3002\u5f53\u6211\u4eec\u5f52\u4e00\u5316\u540c\u671f\u751f\u7269\u5b66\u51fa\u7248\u7269\u7684\u589e\u957f\u6570\u76ee\u65f6\uff0c\u8d8b\u52bf\u4ecd\u7136\u5b58\u5728\uff08\u5982\u56fe2\u6240\u793a\uff09\u3002\u672c\u9879\u7814\u7a76\u6ca1\u6709\u63a7\u5236\u57fa\u56e0\u53d1\u73b0\u540e\u7684\u8fdb\u7a0b\uff0c\u4f46\u4f5c\u8005\u5224\u65ad\u8fd9\u6837\u5047\u8bbe\u5904\u7406\u4e4b\u4e0b\uff0c\u7ed3\u8bba\u4f9d\u7136\u6210\u7acb\u3002&nbsp;<img loading=\"lazy\" data-ratio=\"0.9328703703703703\"  data-type=\"png\" data-w=\"864\" height=\"auto\" width=\"864\" src=\"\/wp-content\/uploads\/2021\/02\/wxsync-2021-02-79849ad0164d0d834b4898595b868445.png\"  \/>\u56fe2. \u57fa\u56e0\u7814\u7a76\u4e2d\u7684\u201c\u504f\u597d\u4f9d\u9644\u201d\u73b0\u8c61&nbsp;\u8fd9\u4e9b\u8054\u7cfb\u63d0\u4f9b\u4e86\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u524d\u540e\u7814\u7a76\u683c\u5c40\u6f14\u53d8\u7684\u5feb\u7167\u3002\u5b83\u8868\u793a\u4e86\u5b66\u672f\u754c\u5bf9\u5c11\u6570\u201c\u8d85\u7ea7\u660e\u661f\u201d\u86cb\u767d\u8d28\u7f16\u7801\u57fa\u56e0\u7684\u5f3a\u70c8\u5173\u6ce8\uff0c\u8fd9\u53ef\u80fd\u4f1a\u51cf\u5c11\u6f5c\u5728\u7684\u3001\u5bf9\u5176\u5b83\u57fa\u56e0\u7684\u7814\u7a76\u3002\u57fa\u56e0\u7ec4\u7684\u975e\u86cb\u767d\u8d28\u7f16\u7801\u90e8\u5206\u4ee5\u53ca\u9057\u4f20\u7269\u8d28\u548c\u86cb\u767d\u8d28\u4e4b\u95f4\u7684\u4e92\u4f5c\u4e00\u76f4\u662f\u7814\u7a76\u7684\u91cd\u70b9\u3002\u4e8b\u5b9e\u662f\uff0c\u836f\u7269\u7814\u53d1\u66f4\u591a\u57fa\u4e8e\u5c11\u6570\u67d0\u4e9b\u86cb\u767d\u8d28\u9776\u70b9\u3002&nbsp;\u5176\u4e2d\u4e00\u4e9b\u8d8b\u52bf\u88ab\u751f\u7269\u5b66\u5bb6\u4eec\u6240\u719f\u6089\uff0c\u4f46\u8981\u91cf\u5316\u548c\u5f62\u8c61\u5316\u8fd9\u4e9b\u8d8b\u52bf\uff0c\u5c31\u5fc5\u987b\u4ee5\u5168\u65b0\u7684\u65b9\u5f0f\u7814\u7a76\u5b83\u4eec\u3002&nbsp;<img loading=\"lazy\" data-ratio=\"0.8987341772151899\"  data-type=\"jpeg\" data-w=\"632\" height=\"auto\" width=\"632\" src=\"\/wp-content\/uploads\/2021\/02\/wxsync-2021-02-577cd05a39d6b44e7310f190a32f3b97.jpeg\"  \/>\u56fe3. 1950\u5e74\u81f32020\u5e74\u57fa\u56e0\u7814\u7a76\u5408\u4f5c\u9879\u76ee\u6210\u5458\u89c4\u6a21\u53d8\u5316&nbsp;\u4e16\u754c\u4e0a\u6ca1\u6709\u53ef\u4e0e\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u6bd4\u80a9\u7684\u5bf9\u7167\u7ec4\u3002\u56e0\u6b64\uff0c\u4e0d\u80fd\u8868\u660e\u4e0a\u8ff0\u8d8b\u52bf\u662f\u5426\u5fc5\u7136\u4f1a\u968f\u7740\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u800c\u51fa\u73b0\u3002\u4ece\u8ba1\u7b97\u80fd\u529b\u7684\u63d0\u9ad8\u5230\u590d\u6742\u7684\u6392\u5e8f\u65b9\u6cd5\u7684\u53d1\u660e\uff0c\u79cd\u79cd\u5916\u90e8\u56e0\u7d20\u4e5f\u5728\u8fd9\u4e9b\u53d1\u5c55\u4e2d\u53d1\u6325\u4e86\u4f5c\u7528\u3002\u552f\u4e00\u53ef\u4ee5\u786e\u5b9a\u7684\u662f\uff0c\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u76ee\u5f55\u63a8\u52a8\u4e86\u57fa\u56e0\u9769\u547d\u7684\u8fdb\u884c\u3002<\/p>\n<p>2. \u201c\u8d85\u7ea7\u660e\u661f\u57fa\u56e0\u201d\u5927\u653e\u5f02\u5f69<\/p>\n<p>\u5b66\u672f\u754c\u666e\u904d\u8ba4\u4e3a\uff0c\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u662f\u5bf9\u86cb\u767d\u8d28\u7f16\u7801\u57fa\u56e0\u6df1\u5165\u7814\u7a76\u7684\u5f00\u59cb\u30022001\u5e74\u53d1\u8868\u7684\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u8349\u56fe\u6807\u5fd7\u7740\u957f\u8fbe\u6570\u5341\u5e74\u7684\u63a2\u7d22\u5de5\u4f5c\u7684\u7ed3\u675f[1,2]\u3002\u4e8b\u5b9e\u4e0a\uff0c\u6700\u65e9\u7684\u86cb\u767d\u8d28\u7f16\u7801\u57fa\u56e0\u7684\u8bc1\u636e\u51fa\u73b0\u57281902\u5e74\u2014\u2014\u5373\u6fc0\u7d20\u5206\u6ccc\u7d20\uff08SCT\u57fa\u56e0\uff09\u7684\u53d1\u73b0[4]\u3002\u6b64\u65f6\u65e9\u4e8eDNA\u7ed3\u6784\u53d1\u73b050\u5e74\u3001\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u666e\u904d\u531675\u5e74\u3002\u672c\u9879\u5206\u6790\u8868\u660e\uff0c\u4ece1990\u5e74\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u7684\u5f00\u59cb\u52302003\u5e74\u5b8c\u6210\uff082001\u5e74\u8349\u56fe\u53d1\u8868\u540e\uff09\uff0c\u4eba\u7c7b\u57fa\u56e0\u7684\u53d1\u73b0\uff08\u6216\u201c\u6ce8\u91ca\u201d\uff09\u6570\u91cf\u6025\u5267\u589e\u957f\u3002\u800c\u57282000\u5e74\u4ee3\u4e2d\u671f\uff0c\u8fd9\u4e2a\u6570\u91cf\u7a81\u7136\u7a33\u5b9a\u4e0b\u6765\u2014\u2014\u7ea6\u67092\u4e07\u4e2a\u86cb\u767d\u8d28\u7f16\u7801\u57fa\u56e0\u88ab\u53d1\u73b0\uff0c\u8fdc\u4f4e\u4e8e\u6b64\u524d\u8bb8\u591a\u79d1\u5b66\u5bb6\u63d0\u51fa\u768410\u4e07\u8fd9\u4e00\u6d77\u91cf\u7684\u4f30\u8ba1\u6570\u3002&nbsp;\u867d\u7136\u86cb\u767d\u8d28\u7f16\u7801\u57fa\u56e0\u7684\u53d1\u73b0\u6570\u91cf\u8fdb\u5165\u4e86\u5e73\u53f0\u671f\uff0c\u4f46\u5728\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u5f00\u59cb\u4e4b\u540e\uff0c\u4eba\u4eec\u5bf9\u5355\u4e2a\u57fa\u56e0\u529f\u80fd\u7684\u5174\u8da3\u8fc5\u901f\u589e\u957f\u3002\u81ea2001\u5e74\u4ee5\u6765\uff0c\u6bcf\u5e74\u90fd\u67091\u4e07\u81f32\u4e07\u7bc7\u5173\u4e8e\u86cb\u767d\u8d28\u7f16\u7801\u57fa\u56e0\u7684\u8bba\u6587\u53d1\u8868\u3002&nbsp;\u7136\u800c\uff0c\u79d1\u5b66\u754c\u7684\u5174\u8da3\u4e3b\u8981\u96c6\u4e2d\u5728\u5c11\u6570\u51e0\u4e2a\u57fa\u56e0\u4e0a\u30021990\u5e74\u4ee5\u524d\uff0cHBA1\u662f\u7814\u7a76\u6700\u591a\u7684\u2014\u2014\u5b83\u662f\u7f16\u7801\u6210\u4eba\u8840\u7ea2\u86cb\u767d\u4e2d\u7684\u4e00\u79cd\u86cb\u767d\u8d28\u3002\u4ece1990\u5e74\u8d77\uff0c\u7531\u4e8eCD4\u86cb\u767d\u53c2\u4e0eT\u7ec6\u80de\u514d\u75ab\u4e14\u4f5c\u4e3aHIV\u7684\u7ec6\u80de\u53d7\u4f53\uff0c\u4eba\u4eec\u7684\u6ce8\u610f\u529b\u8f6c\u79fb\u5230\u4e86CD4\uff08\u7ed3\u8bba\u57fa\u4e8e\u7d2f\u8ba1\u53d1\u8868\u7684\u6587\u732e\u6570\u91cf\u5f97\u51fa\uff09\u3002\u7136\u800c\uff0c\u57282001\u5e74\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u5e8f\u5217\u8349\u56fe\u4e4b\u540e\uff0c\u4eba\u4eec\u5bf9\u8fd9\u4e24\u4e2a\u57fa\u56e0\u7684\u5174\u8da3\u4e0e\u5bf9\u5176\u5b83\u57fa\u56e0\u7684\u5173\u6ce8\u5ea6\u76f8\u6bd4\u5c31\u76f8\u5f62\u89c1\u7ecc\u4e86\u3002\u4e00\u4e9b\u201c\u660e\u661f\u201d\u57fa\u56e0\u2014\u2014\u5982TP53\u3001TNF\u548cEGFR\u2014\u2014\u6210\u4e3a\u4e86\u6bcf\u5e74\u6570\u767e\u7bc7\u8bba\u6587\u7684\u4e3b\u9898\uff0c\u800c\u5176\u5b83\u7684\u5927\u591a\u6570\u57fa\u56e0\u5374\u5f88\u5c11\u53d7\u5230\u5173\u6ce8\u3002\u7edf\u8ba1\u53d1\u73b0\uff0c2017\u5e74\uff0c1%\u7684\u57fa\u56e0\u8986\u76d6\u4e8622%\u7684\u57fa\u56e0\u76f8\u5173\u51fa\u7248\u7269\u4e3b\u9898\u3002&nbsp;<img loading=\"lazy\" data-ratio=\"3.3333333333333335\"  data-type=\"jpeg\" data-w=\"831\" height=\"auto\" width=\"831\" src=\"\/wp-content\/uploads\/2021\/02\/wxsync-2021-02-80b15151421b0ce376710005e29cc6b0-scaled.jpeg\"  \/>\u56fe4. HGP\u95ee\u4e16\u524d\u540e\u5bf9\u57fa\u56e0\u7684\u7814\u7a76\u60c5\u51b5\u3002\u56fe\u4e2d\u7684\u5e73\u9762\u6807\u5fd7\u77402001\u5e74\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u8349\u56fe\u7684\u516c\u5e03\uff0c\u5728\u5176\u4e4b\u4e0b\u7684\u957f\u5ea6\u8868\u793a\u4e3a\u8349\u56fe\u53d1\u8868\u540e\u6709\u5173\u57fa\u56e0\u7684\u6587\u7ae0\u6570\u91cf\u6709\u5173\uff1b\u5728\u5176\u4e4b\u4e0a\u8868\u793a\u5148\u524d\u7684\u51fa\u7248\u7269\u3002\u6bcf\u4e2a\u5cf0\u503c\u5e95\u90e8\u7684\u5bbd\u5ea6\u53cd\u6620\u4e86\u4e0e\u6bcf\u4e2a\u57fa\u56e0\u76f8\u5173\u7684\u75be\u75c5\u6570\u91cf\u3002<br \/>&nbsp;\u5f53\u7136\uff0c\u5bf9\u5177\u6709\u6df1\u8fdc\u751f\u7269\u5b66\u610f\u4e49\u7684\u57fa\u56e0\u8fdb\u884c\u6df1\u5165\u7814\u7a76\u662f\u5fc5\u9700\u7684\u3002TP53\u5c31\u662f\u4e00\u4e2a\u5f88\u597d\u7684\u4f8b\u5b50\u2014\u2014\u5b83\u5bf9\u7ec6\u80de\u7684\u751f\u957f\u548c\u6b7b\u4ea1\u81f3\u5173\u91cd\u8981\uff0c\u4e00\u65e6\u5b83\u5931\u6d3b\u6216\u53d8\u5f02\u5c31\u4f1a\u5bfc\u81f4\u764c\u75c7\uff1a\u4ece1976\u5e74\u81f32017\u5e74\u95f4\uff0c9232\u7bc7\u5b66\u672f\u8bba\u6587\u63d0\u51fa\u8d85\u8fc750%\u7684\u80bf\u7624\u5e8f\u5217\u4e2d\u90fd\u53d1\u73b0\u4e86\u8be5\u57fa\u56e0\u7a81\u53d8\u3002&nbsp;\u6211\u4eec\u7684\u76f4\u89c2\u611f\u53d7\u53ef\u80fd\u4f1a\u8ba4\u4e3a\uff0c\u5bf9\u540c\u4e00\u57fa\u56e0\u4e86\u89e3\u5f97\u8d8a\u591a\uff0c\u5c31\u8d8a\u6709\u52a8\u529b\u53bb\u63a2\u7d22\u57fa\u56e0\u7ec4\u7684\u5176\u4f59\u90e8\u5206\u3002\u7136\u800c\uff0c\u5728\u8fc7\u53bb20\u5e74\u4e8b\u5b9e\u5374\u76f8\u53cd\uff1a\u5927\u90e8\u5206\u7684\u5173\u6ce8\u805a\u7126\u4e8e\u5c11\u6570\u57fa\u56e0\u3002\u5c3d\u7ba1\u5728\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u8349\u56fe\u53d1\u8868\u5341\u5468\u5e74\u4e4b\u9645\uff08\u53732011\u5e74\uff09[5]\uff0c\u8be5\u95ee\u9898\u5c31\u5df2\u7ecf\u88ab\u5e7f\u6cdb\u62a5\u9053\uff0c\u4f46\u76ee\u524d\u4ecd\u6ca1\u6709\u5bf9\u8be5\u95ee\u9898\u5176\u8fdb\u884c\u5b9e\u8d28\u6027\u7684\u4fee\u6b63\u3002&nbsp;\u4e4b\u524d\u5173\u4e8e\u4eba\u7c7b\u793e\u4f1a\u7f51\u7edc\u5230\u4e07\u7ef4\u7f51\u7b49\u4e0d\u540c\u7cfb\u7edf\u7684\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u79cd\u5de8\u5927\u7684\u5931\u8861\u53ef\u4ee5\u7528\u6839\u690d\u4e8e\u793e\u4f1a\u56e0\u7d20\u7684\u201c\u5bcc\u8005\u8d8a\u5bcc\u201d\u6765\u89e3\u91ca[6,7]\u3002\u7684\u786e\uff0c\u968f\u7740\u5173\u4e8eTP53\u7684\u8bba\u6587\u6570\u91cf\u7684\u589e\u52a0\uff0c\u540e\u7eed\u6709\u5173TP53\u7684\u7814\u7a76\u5de5\u4f5c\u66f4\u5bb9\u6613\u83b7\u5f97\u8d44\u91d1\u3001\u6307\u5bfc\u3001\u5de5\u5177\u548c\u5f15\u7528\u2014\u2014\u56e0\u4e3a\u8fd9\u662f\u4e00\u4e2a\u5b89\u5168\u4fdd\u9669\u7684\u6295\u8d44\u3002\u5728\u7f51\u7edc\u79d1\u5b66\u4e2d\uff0c\u8fd9\u79cd\u73b0\u8c61\u88ab\u79f0\u4e3a\u201c\u504f\u597d\u4f9d\u9644\uff08preferential attachment\uff09\u201d[7]\u3002\u4e8b\u5b9e\u4e0a\uff0c\u6211\u4eec\u53d1\u73b0\u5173\u6ce8\u7279\u5b9a\u57fa\u56e0\u7684\u5e74\u5ea6\u65b0\u51fa\u7248\u7269\u6570\u91cf\u4e0e\u5148\u524d\u6709\u5173\u8be5\u57fa\u56e0\u7684\u6587\u732e\u6570\u91cf\u6210\u7ebf\u6027\u6bd4\u4f8b\u3002&nbsp;\u73b0\u5728\u751f\u7269\u5b66\u9762\u4e34\u7684\u4e00\u4e2a\u91cd\u5927\u6311\u6218\u662f\u7406\u6e05\u4e0b\u4e00\u6b65\u7814\u7a76\u7684\u65b9\u5411\u3002\u7814\u7a76\u4eba\u5458\u662f\u8be5\u662f\u628a\u7ecf\u8d39\u3001\u65f6\u95f4\u53ca\u7cbe\u529b\u6295\u5165\u5230\u6700\u91cd\u8981\u6216\u6700\u7d27\u8feb\u7684\u5de5\u4f5c\u4e0a\uff0c\u8fd8\u662f\u56e0\u4e3a\u80fd\u53ef\u9760\u5730\u83b7\u5f97\u8d44\u52a9\u548c\u559d\u5f69\u800c\u6295\u5165\u5230\u66f4\u591a\u91cd\u590d\u7684\u5de5\u4f5c\u4e0a\uff1f&nbsp;<\/p>\n<p><br  \/>3. \u201c\u5783\u573e\u201dDNA\u540c\u6837\u91cd\u8981<\/p>\n<p>\u5728\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u5f00\u59cb\u4e4b\u524d\u6709\u4e00\u573a\u5927\u578b\u8fa9\u8bba\uff1a\u662f\u5426\u503c\u5f97\u7ed8\u5236\u57fa\u56e0\u7ec4\u4e2d\u88ab\u79f0\u4e3a\u5783\u573eDNA\uff08junk DNA\uff09\u6216\u57fa\u56e0\u7ec4\u6697\u7269\u8d28\u7684\u5927\u91cf\u975e\u7f16\u7801\u533a\uff1f\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u5f52\u529f\u4e8e\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\uff0c\u73b0\u5728\u4eba\u4eec\u8ba4\u8bc6\u5230\uff0c\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u7684\u5927\u591a\u6570\u529f\u80fd\u5e8f\u5217\u5e76\u4e0d\u7f16\u7801\u86cb\u767d\u8d28\u3002\u76f8\u53cd\uff0c\u662f\u8bf8\u5982\u957f\u94fe\u975e\u7f16\u7801RNA\uff08long noncoding RNA\uff0clncRNA\uff09\u3001\u542f\u52a8\u5b50\u3001\u589e\u5f3a\u5b50\u548c\u65e0\u6570\u57fa\u56e0\u8c03\u63a7\u5e8f\u5217\u7b49\u5143\u4ef6\u5171\u540c\u4f5c\u7528\u4f7f\u57fa\u56e0\u7ec4\u590d\u6742\u4f46\u6709\u5e8f\u5730\u6307\u5bfc\u751f\u547d\u6d3b\u52a8\u3002\u8fd9\u4e9b\u533a\u57df\u7684\u53d8\u5f02\u4e0d\u4f1a\u6539\u53d8\u86cb\u767d\u8d28\uff0c\u4f46\u901a\u8fc7\u6270\u4e71\u63a7\u5236\u86cb\u767d\u8d28\u8868\u8fbe\u7684\u7f51\u7edc\u6765\u5f71\u54cd\u751f\u547d\u6d3b\u52a8\u7684\u8fdb\u884c\u3002&nbsp;\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u8349\u56fe\u53d1\u5e03\u540e\uff0c\u975e\u86cb\u767d\u7f16\u7801\u5143\u4ef6\u7684\u53d1\u73b0\u5982\u96e8\u540e\u6625\u7b0b\u822c\u7206\u53d1\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8fd9\u79cd\u589e\u957f\u6570\u91cf\u5df2\u7ecf\u8d85\u8fc7\u4e86\u86cb\u767d\u8d28\u7f16\u7801\u57fa\u56e0\u53d1\u73b0\u91cf\u7684\u4e94\u500d\uff0c\u4e14\u4ecd\u6ca1\u6709\u653e\u7f13\u7684\u8ff9\u8c61\u3002\u540c\u65f6\uff0c\u5728\u672c\u9879\u7814\u7a76\u6240\u7528\u6570\u636e\u96c6\u6db5\u76d6\u7684\u65f6\u671f\uff081900\u81f32017\u5e74\uff09\u5185\uff0c\u5173\u4e8e\u8fd9\u4e9b\u8c03\u63a7\u5143\u4ef6\u7684\u53d1\u8868\u7269\u6570\u91cf\u4e5f\u5728\u589e\u957f\u2014\u2014\u4f8b\u5982\uff0c\u5173\u4e8e\u8c03\u8282\u57fa\u56e0\u8868\u8fbe\u7684\u975e\u7f16\u7801RNA\u7684\u8bba\u6587\u6570\u4ee5\u5343\u8ba1\u3002&nbsp;<img loading=\"lazy\" data-backh=\"240\" data-backw=\"562\" data-ratio=\"0.42731921110299487\"  data-type=\"png\" data-w=\"1369\" height=\"auto\" style=\"width: 100%;height: auto;\" width=\"1369\" src=\"\/wp-content\/uploads\/2021\/02\/wxsync-2021-02-28e911c0e62471f9c59b79cad5b5f4d0.png\"  \/>\u56fe5.&nbsp;\u5173\u4e8e\u975e\u7f16\u7801RNA\u7684\u7814\u7a76\u5448\u73b0\u660e\u663e\u9012\u589e\u8d8b\u52bf&nbsp;\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u8fd8\u63d0\u4f9b\u4e86\u4e00\u79cd\u7f16\u76ee\u4eba\u7c7b\u9057\u4f20\u53d8\u5f02\uff08\u5305\u62ec\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff0c Single Nucleotide Polymorphism, SNP\uff09\u7684\u65b9\u6cd5\u3002\u5176\u5b83\u4e00\u4e9b\u91cd\u5927\u4e3e\u63aa\u80fd\u5927\u5e45\u524a\u51cf\u4e86\u5bf9\u6570\u5343\u4eba\u7684\u5171\u540c\u5dee\u5f02\u8fdb\u884c\u5206\u6790\u7684\u6210\u672c\uff1b\u5176\u4e2d\u5305\u62ec\u56fd\u9645HapMap\u9879\u76ee[8]\u548c\u56fd\u9645\u5343\u4eba\u57fa\u56e0\u7ec4\u8ba1\u5212[9]\u3002\u8fd9\u4e9b\u6570\u636e\u96c6\u548c\u4e4b\u524d\u7684\u7edf\u8ba1\u5206\u6790\u7b49\u5e26\u6765\u4e86\u65e0\u6570\u5173\u4e8e\u6027\u72b6\u7684\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08genome-wide association studies, GWAS\uff09\uff0c\u5177\u4f53\u5982\u8eab\u9ad8[10]\u3001\u80a5\u80d6\u7a0b\u5ea6[11]\u548c\u5bf9\u590d\u6742\u75be\u75c5\uff08\u7cbe\u795e\u5206\u88c2\u75c7\u7b49\uff09\u7684\u6613\u611f\u5ea6[12]\u3002&nbsp;\u73b0\u5728\u6bcf\u5e74\u6709\u8d85\u8fc73\u4e07\u7bc7\u6587\u7ae0\u5c06\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\u4e0e\u751f\u7269\u6027\u72b6\u8054\u7cfb\u8d77\u6765\u3002\u5f88\u5927\u4e00\u90e8\u5206\u5173\u8054\u5b58\u5728\u4e8e\u66fe\u7ecf\u88ab\u5ffd\u7565\u7684\u975e\u7f16\u7801\u533a\u57df\u3002&nbsp;\u7ec6\u80de\u529f\u80fd\u4f9d\u8d56\u4e8e\u9057\u4f20\u7269\u8d28\u548c\u86cb\u767d\u8d28\u4e4b\u95f4\u7684\u5f3a\u5f31\u8054\u7cfb\u3002\u76ee\u524d\uff0c\u5df2\u6709\u8d85\u8fc730\u4e07\u4e2a\u57fa\u56e0\u8c03\u8282\u7f51\u7edc\uff08regulatory network\uff09\u7684\u76f8\u4e92\u4f5c\u7528\u5173\u7cfb\u88ab\u8868\u793a\u51fa\u6765\uff0c\u5373\u86cb\u767d\u8d28\u4e0e\u975e\u7f16\u7801\u5e8f\u5217\u4e92\u4f5c\u6216\u86cb\u767d\u4e4b\u95f4\u4e92\u4f5c\u3002&nbsp;<\/p>\n<p>4. \u7cbe\u51c6\u52a9\u529b\u836f\u7269\u5f00\u53d1<\/p>\n<p>\u5927\u7ea6\u572820\u4e16\u7eaa80\u5e74\u4ee3\u4e4b\u524d\uff0c\u5927\u591a\u6570\u836f\u7269\u7684\u53d1\u73b0\u6e90\u81ea\u5076\u7136\u3002\u836f\u7269\u5206\u5b50\u4e0e\u5176\u5206\u5b50\u9776\u70b9\u901a\u5e38\u662f\u672a\u77e5\u7684\u30022001\u5e74\u4e4b\u524d\uff0c\u4e86\u89e3\u836f\u7269\u6240\u6709\u86cb\u767d\u8d28\u9776\u70b9\u7684\u6982\u7387\u5747\u5c0f\u4e8e50%\u3002\u5728\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u51fa\u73b0\u540e\uff0c\u4e00\u5207\u53d1\u751f\u4e86\u8f6c\u673a\u3002\u8fd1\u5e74\u6765\uff0c\u7f8e\u56fd\u51e0\u4e4e\u6240\u6709\u83b7\u5f97\u8bb8\u53ef\u7684\u836f\u7269\u90fd\u80fd\u6e05\u695a\u77e5\u6653\u5176\u86cb\u767d\u8d28\u9776\u70b9\u3002&nbsp;<img loading=\"lazy\" data-ratio=\"2.422382671480144\"  data-type=\"jpeg\" data-w=\"831\" height=\"auto\" width=\"831\" src=\"\/wp-content\/uploads\/2021\/02\/wxsync-2021-02-8f34d8720281f105c864105ac7c859f4.jpeg\"  \/>\u56fe6. \u81ea\u57fa\u56e0\u7ec4\u8ba1\u5212\u95ee\u4e1620\u5e74\u6765\u201c\u660e\u661f\u201d\u57fa\u56e0\u3001\u201c\u5783\u573e\u201dDNA\u548c\u836f\u7269\u7684\u7814\u7a76\u8d8b\u52bf<br \/>&nbsp;\u7814\u7a76\u540c\u65f6\u53d1\u73b0\uff0c\u5728\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u63d0\u4f9b\u7684\u7ea620000\u4e2a\u53ef\u4f5c\u4e3a\u6f5c\u5728\u836f\u7269\u9776\u70b9\u7684\u86cb\u767d\u8d28\u5e8f\u5217\u4e2d\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\u53ea\u6709\u7ea610%\uff0c\u53732149\u4e2a\u662f\u88ab\u6279\u51c6\u7684\u836f\u7269\u9776\u70b9\uff0c\u8fd9\u8868\u660e\u5176\u4f5990%\u7684\u86cb\u767d\u8d28\u7ec4\u4e0d\u53d7\u836f\u7406\u5b66\u7684\u5f71\u54cd[13]\u3002\u5728\u6211\u4eec\u7684\u6570\u636e\u96c6\u4e2d\uff0c\u5b9e\u9a8c\u836f\u7269\u5c06\u8fd9\u4e2a\u6570\u5b57\u589e\u52a0\u52303,119\u3002\u540c\u6837\uff0c\u4eba\u4eec\u5bf9\u8fd9\u4e9b\u95ee\u9898\u7684\u5173\u6ce8\u5ea6\u4e5f\u662f\u4e0d\u5c3d\u76f8\u540c\u3002\u76ee\u524d\u6279\u51c6\u7684\u6240\u6709\u836f\u7269\uff0899\u79cd\u4e0d\u540c\u7684\u5206\u5b50\uff09\u4e2d\uff0c\u67095%\u662f\u4ee5\u53c2\u4e0e\u7ec6\u80de\u751f\u957f\u548c\u589e\u6b96\u7684\u86cb\u767d\u8d28ADRA1A\u4e3a\u9776\u70b9\u3002&nbsp;\u540c\u6837\u5730\uff0c\u8fd9\u79cd\u201c\u4e0d\u5e73\u8861\u201d\u4e5f\u6709\u5176\u5b58\u5728\u7684\u7406\u7531\u3002\u6709\u4e00\u4e9b\u86cb\u767d\u8d28\u53ef\u80fd\u5bf9\u4eba\u7c7b\u5065\u5eb7\u66f4\u91cd\u8981\uff0c\u6216\u66f4\u503e\u5411\u4e8e\u6210\u4e3a\u65b0\u7684\u836f\u7269\u9776\u70b9\uff0c\u800c\u6709\u4e9b\u86cb\u767d\u8d28\u53ef\u80fd\u65e0\u6cd5\u6709\u52a9\u4e8e\u836f\u7269\u7814\u53d1\u3002\u4f46\u6362\u8a00\u4e4b\uff0c\u5982\u679c\u7814\u7a76\u4eba\u5458\u3001\u8d5e\u52a9\u65b9\u548c\u51fa\u7248\u5546\u4e0d\u90a3\u4e48\u89c4\u907f\u98ce\u9669\uff0c\u5219\u53ef\u80fd\u6709\u66f4\u591a\u7684\u86cb\u767d\u8d28\u88ab\u4eba\u4eec\u63a2\u7d22\uff0c\u4ece\u800c\u6210\u4e3a\u65b0\u5174\u836f\u7269\u9776\u70b9\u3002&nbsp;\u4e5f\u5c31\u662f\u8bf4\uff0c\u5927\u591a\u6570\u88ab\u6210\u529f\u7814\u53d1\u7684\u836f\u7269\u5e76\u4e0d\u76f4\u63a5\u9488\u5bf9\u4e2a\u522b\u75be\u75c5\u57fa\u56e0[14]\u3002\u76f8\u53cd\uff0c\u5b83\u4eec\u7684\u76ee\u6807\u662f\u4e00\u4e24\u4e2a\u76f8\u4e92\u4f5c\u7528\u7684\u86cb\u767d\u8d28\u8c03\u63a7\u9519\u8bef\u7ec4\u6210\u7684\u7ed3\u679c\u3002\u4f8b\u5982\uff0c\u6211\u4eec\u5bf9\u73b0\u6709\u53ef\u6cbb\u7597COVID-19\u7684\u836f\u7269\u8fdb\u884c\u5927\u89c4\u6a21\u7b5b\u67e5\u540e\u53d1\u73b0\uff0c\u53ea\u67091%\u7684\u836f\u7269\u6709\u5e0c\u671b\u9488\u5bf9\u75c5\u6bd2\u86cb\u767d\uff0c\u800c\u5927\u591a\u6570\u4e34\u5e8a\u836f\u7269\u65e8\u5728\u7528\u4e8e\u8c03\u8282\u4eba\u7c7b\u86cb\u767d\uff0c\u4e14\u8fd9\u4e9b\u86cb\u767d\u5e76\u4e0d\u76f4\u63a5\u5f71\u54cdSARS-CoV-2\u75c5\u6bd2\u7684\u6d3b\u6027[15]\u3002&nbsp;<\/p>\n<p>5. \u751f\u7269\u7f51\u7edc\u9010\u6e10\u660e\u6717<\/p>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0c\u6211\u4eec\u8ba4\u4e3a\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u6bd4\u86cb\u767d\u8d28\u76ee\u5f55\u672c\u8eab\u66f4\u503c\u5f97\u5173\u6ce8\uff0c\u56e0\u4e3a\u5b83\u5f00\u521b\u4e86\u57fa\u56e0\u7ec4\u5b66\u7684\u65b0\u65f6\u4ee3\u3002\u6b63\u5982\u590d\u6742\u7cfb\u7edf\u7406\u8bba\u6240\u8868\u660e\u7684\u90a3\u6837\uff1a\u7406\u89e3\u4efb\u4f55\u4e00\u4e2a\u7cfb\u7edf\u3001\u5bf9\u5176\u4e2d\u6bcf\u4e2a\u5143\u7d20\u8fdb\u884c\u7cbe\u786e\u8c03\u67e5\u662f\u5fc5\u8981\u7684\uff0c\u4f46\u53c8\u8fdc\u8fdc\u4e0d\u80fd\u6b62\u6b65\u4e8e\u6b64\u3002\u7f51\u7edc\u7684\u590d\u6742\u6027\u6070\u6070\u6765\u81ea\u4e8e\u5143\u7d20\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u591a\u6837\u6027\u3002\u7ecf\u8fc720\u5e74\u4ee5\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u4e3a\u57fa\u7840\u7684\u7814\u7a76\uff0c\u751f\u7269\u5b66\u4eec\u5bb6\u73b0\u5728\u5bf9\u5b9a\u4e49\u751f\u547d\u7684\u7f51\u7edc\u7ed3\u6784\u548c\u52a8\u529b\u5b66\u6709\u4e86\u521d\u6b65\u4e86\u89e3\u3002\u672a\u6765\uff0c\u6211\u4eec\u4e5f\u5e0c\u671b\u6709\u66f4\u957f\u8db3\u7684\u8fdb\u6b65\u3002&nbsp;\u53c2\u8003\u6587\u732e\uff1a[1]Venter, J. C. et al. Science 291, 1304\u20131351 (2001).[2]International Human Genome Sequencing Consortium. Nature 409, 860\u2013921 (2001).[3]Portin, P. &amp; Wilkins, A. Genetics 205, 1353\u20131364 (2017).[4]Bayliss, W. M. &amp; Starling, E. H. J. Physiol. 28, 325\u2013353 (1902).[5]Edwards, A. M. et al. Nature 470, 163\u2013165 (2011).[6]Bianconi, G. &amp; Barab\u00e1si, A.-L. Europhys. Lett. 54, 436 (2001).[7]Barab\u00e1si, A.-L. &amp; Albert, R. Science 286, 509\u2013512 (1999).[8]The International HapMap Consortium. Nature 426, 789\u2013796 (2003).[9]The 1000 Genomes Project Consortium. Nature 526, 68\u201374 (2015).[10]Lango Allen, H. et al. Nature 467, 832\u2013838 (2010).[11]Speliotes, E. K. et al. Nature Genet. 42, 937\u2013948 (2010).[12]Lencz, T. et al. Mol. Psychiatry 12, 572\u2013580 (2007).[13]Wishart, D. S. et al. Nucleic Acids Res. 46, D1074\u2013D1082 (2018).[14]Yildirim, M. A., Goh, K.-Il, Cusick, M. E., Barab\u00e1si, A. L. &amp; Vidal, M. Nature Biotechnol. 25, 1119\u20131126 (2007).[15]Gysi, D. M. et al. Preprint at&nbsp;https:\/\/arxiv.org\/abs\/2004.07229&nbsp;(2020).<br  \/>\u539f\u6587\u94fe\u63a5\uff1a<br \/>https:\/\/www.nature.com\/articles\/d41586-021-00314-6<\/p>\n<p><br  \/>\u7f51\u7edc\u79d1\u5b66\u65b0\u8bfe\u63a8\u8350\uff1a\u7f51\u7edc\u52a8\u529b\u5b66<\/p>\n<p><br style=\"color: rgb(63, 63, 63);font-family: PingFangSC-light;font-size: 15px;letter-spacing: 0.544px;\"  \/><br \/>\u96c6\u667a\u5b66\u56ed\u7279\u9080\u9648\u5173\u8363\u3001\u9879\u6797\u82f1\u3001\u6a0a\u745b\u3001\u5ba3\u7426\u3001\u674e\u7fd4\u3001\u53f2\u5b9a\u534e\u3001\u674e\u806a\u3001\u8363\u667a\u6d77\u3001\u5468\u8fdb\u3001\u738b\u7433\u7b49\u7f51\u7edc\u79d1\u5b66\u4e13\u5bb6\u4f5c\u4e3a\u5bfc\u5e08\uff0c\u4f9d\u6258\u6c6a\u5c0f\u5e06\u3001\u674e\u7fd4\u3001\u9648\u5173\u8363\u7684\u7ecf\u5178\u6559\u6750\u300a\u7f51\u7edc\u79d1\u5b66\u5bfc\u8bba\u300b\uff0c\u81ea2\u670827\u65e5\u8d77\u5f00\u5c55\u7cfb\u5217\u4e0a\u7ebf\u8bfe\u7a0b\uff0c\u4ee5\u7f51\u7edc\u52a8\u529b\u5b66\u4e3a\u4e3b\u7ebf\u6784\u5efa\u7f51\u7edc\u79d1\u5b66\u77e5\u8bc6\u4f53\u7cfb\u3002\u6b22\u8fce\u5e0c\u671b\u8fdb\u5165\u7f51\u7edc\u79d1\u5b66\u9886\u57df\u3001\u63d0\u9ad8\u7f51\u7edc\u5206\u6790\u80fd\u529b\u3001\u4e0e\u4e00\u7ebf\u4e13\u5bb6\u63a2\u8ba8\u95ee\u9898\u7684\u670b\u53cb\u62a5\u540d\u53c2\u52a0\uff01<br \/><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247537042&amp;idx=1&amp;sn=f050cc6fb7f489c90bff19f97971652d&amp;chksm=e8970b1fdfe08209787a9395ceb9d977a97124f0b5c4dae042c24a8a42312ba34501cd6958c9&amp;scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" rel=\"noopener noreferrer\"><img class=\"rich_pages\" data-cropselx1=\"0\" data-cropselx2=\"562\" data-cropsely1=\"0\" data-cropsely2=\"239\" data-ratio=\"1.7777777777777777\" data-s=\"300,640\"  data-type=\"png\" data-w=\"1242\" style=\"width: 562px;height: 999px;margin: 0px;box-sizing: border-box !important;visibility: visible !important;\" src=\"\/wp-content\/uploads\/2021\/02\/wxsync-2021-02-e0f9cf9a9f96e98e26197b6b6ade4611.png\"  \/><\/a>\u70b9\u51fb\u67e5\u770b\u8bfe\u7a0b\u8be6\u60c5\uff1a<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247537042&amp;idx=1&amp;sn=f050cc6fb7f489c90bff19f97971652d&amp;chksm=e8970b1fdfe08209787a9395ceb9d977a97124f0b5c4dae042c24a8a42312ba34501cd6958c9&amp;scene=21#wechat_redirect\" data-itemshowtype=\"0\" tab=\"innerlink\" style=\"font-size: 15px;text-decoration: underline;\" data-linktype=\"2\" rel=\"noopener noreferrer\">2021\u91cd\u78c5\u65b0\u8bfe\uff1a\u63a2\u7d22\u7f51\u7edc\u52a8\u529b\u5b66\u2014\u2014\u7f51\u7edc\u79d1\u5b66\u7b2c\u4e8c\u671f<\/a><\/p>\n<p>\u63a8\u8350\u9605\u8bfb<\/p>\n<p><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247534067&amp;idx=1&amp;sn=79f685767088cf04a5a3f0546d37b79c&amp;chksm=e8971f7edfe096681064006cc50d5ecdadb71482f8f54ec0f0c0eb309879770c30ff73956c78&amp;scene=21#wechat_redirect\" data-itemshowtype=\"0\" tab=\"innerlink\" style=\"text-decoration: underline;\" data-linktype=\"2\" rel=\"noopener noreferrer\">DNA\u5f71\u5b50\u5973\u58eb\u4e28\u9648\u5173\u8363<\/a><br \/><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247492586&amp;idx=1&amp;sn=db15b8d87dbaf5abc15993b6ad78bcea&amp;chksm=e897b967dfe030718b17e0088378a7e6007886cca4510855db86829d26bc6d5001170c8e93df&amp;scene=21#wechat_redirect\" data-itemshowtype=\"0\" tab=\"innerlink\" style=\"text-decoration: underline;\" data-linktype=\"2\" rel=\"noopener noreferrer\">\u8fdb\u5316\u65b0\u89c6\u89d2\uff1a\u57fa\u56e0\u4e4b\u95f4\u7684\u91cd\u590d\u535a\u5f08\u5982\u4f55\u5f71\u54cd\u751f\u7269\u8fdb\u5316\uff1f<\/a><br \/><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247488233&amp;idx=1&amp;sn=74ff765874db6f3ca5ace0dbd0f400a0&amp;chksm=e8944864dfe3c172757928cd8d003fa1cbb698afb6ea1755c4f274653e4b7066d6126c69263d&amp;scene=21#wechat_redirect\" data-itemshowtype=\"0\" tab=\"innerlink\" style=\"text-decoration: underline;\" data-linktype=\"2\" rel=\"noopener noreferrer\">\u7ec6\u80de\u9700\u8981\u591a\u5c11\u57fa\u56e0\uff1f\u4e00\u4e2a\u90fd\u4e0d\u80fd\u5c11\uff01<\/a><\/p>\n<p><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247487778&amp;idx=1&amp;sn=c2e77ec93213c4c63f57a777ff10e368&amp;chksm=e8944bafdfe3c2b9d66544dafe7403159473e8c94fd3bc513f5300c353bcec49c0c0b69797af&amp;scene=21#wechat_redirect\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);cursor: pointer;\" rel=\"noopener noreferrer\">\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/a><\/p>\n<p>\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u8ffd\u8e2a\u590d\u6742\u79d1\u5b66\u9876\u520a\u8bba\u6587                 <\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5bfc\u8bed \u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\uff08Human Genome Project, HGP\uff09\u662f\u4e00\u9879\u89c4\u6a21\u5b8f\u5927\u3001\u8de8\u56fd\u8de8\u5b66\u79d1\u7684\u79d1\u5b66\u63a2\u7d22\u5de5\u7a0b\u3002\u5176\u5b97\u65e8\u5728\u4e8e\u6d4b\u5b9a\u7ec4\u6210\u4eba\u7c7b\u67d3\u8272\u4f53\uff08\u6307\u5355\u500d\u4f53\uff09\u4e2d\u6240\u5305\u542b\u7684\u753130\u4ebf\u4e2a\u78b1\u57fa\u5bf9\u6240\u7ec4\u6210\u7684\u6838\u82f7\u9178\u5e8f\u5217\uff0c\u4ece\u800c\u7ed8\u5236\u4eba\u7c7b\u57fa\u56e0\u7ec4\u56fe\u8c31\u3001\u8fa8\u8bc6\u5176\u8f7d\u6709\u7684\u57fa\u56e0\u53ca\u5176\u5e8f\u5217\uff0c\u8fbe\u5230\u7834\u8bd1\u4eba\u7c7b\u9057\u4f20\u4fe1\u606f\u7684\u6700\u7ec8\u76ee\u7684\u30022021\u5e742\u67081&#8230;<\/p>\n","protected":false},"author":1,"featured_media":23932,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/23940"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23940"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/23940\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/23932"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23940"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=23940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}