{"id":24278,"date":"2021-03-06T15:08:04","date_gmt":"2021-03-06T07:08:04","guid":{"rendered":"https:\/\/swarma.org\/?p=24278"},"modified":"2021-03-06T15:08:04","modified_gmt":"2021-03-06T07:08:04","slug":"%e7%94%9f%e7%89%a9%e7%89%a9%e7%90%86%e5%89%8d%e6%b2%bf%ef%bc%9a%e9%87%8f%e5%8c%96%e7%bb%86%e8%83%9e%e5%86%85%e7%94%9f%e5%8c%96%e4%bf%a1%e5%8f%b7%e5%88%86%e5%ad%90%e5%8a%a8%e5%8a%9b%e5%ad%a6%e7%bc%96","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=24278","title":{"rendered":"\u751f\u7269\u7269\u7406\u524d\u6cbf\uff1a\u91cf\u5316\u7ec6\u80de\u5185\u751f\u5316\u4fe1\u53f7\u5206\u5b50\u52a8\u529b\u5b66\u7f16\u7801\u7684\u4fe1\u606f\u79ef\u7d2f"},"content":{"rendered":"
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\u5bfc\u8bed<\/p>\n

\u5f53\u7ec6\u80de\u5916\u73af\u5883\u53d1\u751f\u53d8\u5316\u65f6\uff0c\u7ec6\u80de\u5185\u4fe1\u53f7\u5206\u5b50\u7684\u8868\u8fbe\u91cf\u4f1a\u76f8\u5e94\u53d8\u5316\u6765\u8c03\u63a7\u7ec6\u80de\u4ea7\u751f\u5e94\u6fc0\u53cd\u5e94\u3002\u7406\u89e3\u548c\u91cf\u5316\u4fe1\u53f7\u5206\u5b50\u52a8\u529b\u5b66\u4f20\u9012\u7684\u4fe1\u606f\u662f\u5b9a\u91cf\u751f\u7269\u9886\u57df\u7684\u4e00\u4e2a\u96be\u9898\u3002\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u5b9a\u91cf\u4e0e\u8ba1\u7b97\u751f\u7269\u79d1\u5b66\u7814\u7a76\u6240\u7684\u591a\u4f4d\u5b66\u8005\uff0c\u5f00\u53d1\u4e86\u4e00\u4e2a\u8ba1\u7b97\u65b9\u6cd5\u6765\u56de\u7b54\u8fd9\u4e2a\u95ee\u9898\uff0c\u8fd1\u65e5\u53d1\u8868\u4e8e Nature Communications\u3002\u4f5c\u8005\u5229\u7528\u9690\u9a6c\u5c14\u53ef\u592b\u6a21\u578b\u5b66\u4e60\u548c\u91cd\u6784\u4e86\u5355\u7ec6\u80de\u4fe1\u53f7\u5206\u5b50\u7684\u52a8\u529b\u5b66\uff0c\u5e76\u8ba1\u7b97\u4e86\u6570\u636e\u7684\u8f68\u8ff9\u71b5\u548c\u52a8\u529b\u5b66\u4e92\u4fe1\u606f\uff0c\u4ee5\u6b64\u91cf\u5316\u4e86\u7ec6\u80de\u901a\u8fc7\u751f\u5316\u4fe1\u53f7\u5206\u5b50\u6709\u6548\u5730\u533a\u5206\u523a\u6fc0\u7269\u7684\u6570\u91cf\u548c\u987a\u5e8f\u3002
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\u6c64\u8fce | \u4f5c\u8005\u9093\u4e00\u96ea | \u7f16\u8f91<\/p>\n

 <\/p>\n

\u8bba\u6587\u9898\u76ee\uff1a
Quantifying information accumulation encoded in the dynamics of biochemical signaling
\u8bba\u6587\u5730\u5740\uff1ahttps:\/\/www.nature.com\/articles\/s41467-021-21562-0<\/p>\n

1. \u80cc\u666f\u4ecb\u7ecd<\/p>\n

\u5f53\u7ec6\u80de\u9047\u5230\u73af\u5883\u4e2d\u7684\u523a\u6fc0\u7269\u65f6\uff0c\u7ec6\u80de\u5185\u4fe1\u53f7\u5206\u5b50\u7684\u8868\u8fbe\u91cf\u4f1a\u53d1\u751f\u53d8\u5316\uff0c\u4ee5\u6b64\u8c03\u63a7\u7ec6\u80de\u4ea7\u751f\u5e94\u6fc0\u53cd\u5e94\u3002\u5f53\u7ec6\u80de\u9002\u5e94\u73af\u5883\u53d8\u5316\u65f6\uff0c\u7ec6\u80de\u5185\u7684\u4fe1\u53f7\u8f6c\u5bfc\u4f1a\u7528\u968f\u65f6\u95f4\u53d8\u5316\u7684\u4fe1\u53f7\u5206\u5b50\u7684\u52a8\u529b\u5b66\u6765\u7f16\u7801\u548c\u4f20\u9012\u4fe1\u606f\uff0c\u5373\u4fe1\u606f\u88ab\u7f16\u7801\u5728\u4fe1\u53f7\u5206\u5b50\u7684\u590d\u6742\u52a8\u529b\u5b66\u4e2d\u3002\u8fd1\u5e74\u6765\u968f\u7740\u5b9e\u9a8c\u6280\u672f\u7684\u53d1\u5c55\uff0c\u7814\u7a76\u751f\u7269\u7cfb\u7edf\u4e2d\u7684\u5355\u7ec6\u80de\u6570\u636e\u4e0d\u65ad\u79ef\u7d2f [1]\uff0c\u79d1\u5b66\u5bb6\u4eec\u53ef\u4ee5\u5b9e\u65f6\u6d4b\u91cf\u591a\u4e2a\u5355\u7ec6\u80de\u5185\u7684\u4fe1\u53f7\u5206\u5b50\u8868\u8fbe\u91cf\u968f\u65f6\u95f4\u53d8\u5316\u7684\u6570\u636e\uff0c\u8fd9\u5c31\u4ea7\u751f\u4e86\u4e00\u7ec4\u590d\u6742\u7684\u968f\u673a\u65f6\u95f4\u5e8f\u5217\u7ec4\u3002\u8fd9\u7c7b\u6570\u636e\u4e2d\u5f80\u5f80\u5e26\u6709\u86cb\u767d\u968f\u673a\u8868\u8fbe\u5e26\u6765\u7684\u566a\u58f0\uff0c\u7ec6\u80de\u4e0e\u7ec6\u80de\u95f4\u9ad8\u5ea6\u7684\u5f02\u8d28\u6027\u5e26\u6765\u7684\u968f\u673a\u6027\u3002\u6b64\u7c7b\u65f6\u95f4\u5e8f\u5217\u7684\u52a8\u529b\u5b66\u6784\u8c61\u7a7a\u95f4\u4e5f\u5f88\u590d\u6742 [2]\uff0c\u5176\u53ef\u80fd\u7684\u8f68\u8ff9\u6784\u8c61\u6570\u76ee\u4f1a\u968f\u7740\u65f6\u95f4\u70b9\u7684\u6570\u91cf\u800c\u6307\u6570\u589e\u52a0\u3002\u8fd9\u4e9b\u7279\u70b9\u90fd\u4e3a\u65f6\u95f4\u5e8f\u5217\u7684\u7cbe\u786e\u5206\u6790\u5e26\u6765\u4e86\u6311\u6218\u3002<\/p>\n


\u56fe1\uff1a\u5f53\u7ec6\u80de\u53d7\u5230\u523a\u6fc0\u65f6\uff0c\u7ec6\u80de\u5185\u4fe1\u53f7\u5206\u5b50\u7684\u53cd\u5e94\u4f1a\u5c06\u4fe1\u606f\u4f20\u9012\u81f3\u7ec6\u80de\u6838\u3002\u4fe1\u53f7\u5206\u5b50\u8868\u8fbe\u548c\u523a\u6fc0\u7269\u4e4b\u95f4\u7684\u4e92\u4fe1\u606f\u53ef\u4ee5\u91cf\u5316\u7ec6\u80de\u80fd\u6709\u6548\u533a\u5206\u7684\u523a\u6fc0\u7269\u6570\u91cf\u3002<\/p>\n

\u5bf9\u4e8e\u8fd9\u7c7b\u6570\u636e\uff0c\u5f80\u5f80\u6ca1\u6709\u9884\u5148\u77e5\u9053\u7684\u6570\u5b66\u65b9\u7a0b\u6765\u63cf\u8ff0\uff0c\u6570\u636e\u4e2d\u7684\u968f\u673a\u6027\u4e5f\u4f1a\u964d\u4f4e\u7528\u5b9a\u91cf\u6a21\u578b\u6765\u5b66\u4e60\u548c\u5206\u6790\u65f6\u95f4\u5e8f\u5217\u7684\u51c6\u786e\u6027\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u8005\u5e94\u7528\u6982\u7387\u610f\u4e49\u4e0b\u7684\u4fe1\u606f\u8bba\u6765\u5206\u6790\u5355\u7ec6\u80de\u4fe1\u53f7\u5206\u5b50\u6570\u636e\u4e2d\u7684\u6709\u6548\u4fe1\u606f [3]\uff0c\u5176\u4e2d\u523a\u6fc0\u7269\u548c\u5355\u7ec6\u80de\u4fe1\u53f7\u5206\u5b50\u8868\u8fbe\u91cf\u4e4b\u95f4\u7684\u4e92\u4fe1\u606f\uff08Mutual Information\uff09\u53ef\u4ee5\u5ea6\u91cf\u7ec6\u80de\u80fd\u4ee5\u8be5\u4fe1\u53f7\u5206\u5b50\u6709\u6548\u533a\u5206\u7684\u4e0d\u540c\u523a\u6fc0\u7269\u79cd\u7c7b\uff08\u56fe1\uff09\u3002\u7136\u800c\uff0c\u566a\u58f0\u4f1a\u5f71\u54cd\u8ba1\u7b97\u4e92\u4fe1\u606f\u7684\u51c6\u786e\u5ea6\uff0c\u7ed9\u8ba1\u7b97\u7ec6\u80de\u5185\u4fe1\u53f7\u5206\u5b50\u7684\u4fe1\u606f\u4f20\u9012\u5e26\u6765\u5e72\u6270\u3002\u7279\u522b\u5730\uff0c\u5982\u4f55\u91cf\u5316\u4fe1\u53f7\u5206\u5b50\u52a8\u529b\u5b66\u6784\u8c61\u4e2d\u968f\u7740\u65f6\u95f4\u7684\u4fe1\u606f\u7d2f\u79ef\u662f\u4e00\u4e2a\u5c1a\u672a\u89e3\u51b3\u7684\u95ee\u9898\u3002<\/p>\n

 <\/p>\n

2. \u52a8\u529b\u5b66\u4e92\u4fe1\u606f<\/p>\n

\u8ba1\u7b97\u7ec6\u80de\u5185\u4fe1\u53f7\u5206\u5b50\u7684\u4fe1\u606f\u4f20\u9012\u662f\u5b9a\u91cf\u751f\u7269\u9886\u57df\u8fd1\u4e9b\u5e74\u7684\u4e00\u4e2a\u70ed\u70b9\u95ee\u9898\u3002\u5728\u4ee5\u5f80\u7684\u7814\u7a76\u4e2d\uff0c\u6587\u732e [3]\u5229\u7528\u5355\u4e2a\u65f6\u95f4\u70b9\u7684\u6570\u636e\u8ba1\u7b97\u4e86\u4e92\u4fe1\u606f\u3002\u4f46\u8be5\u65b9\u6cd5\u65e0\u6cd5\u5f97\u5230\u4fe1\u53f7\u5206\u5b50\u5728\u4e00\u4e2a\u65f6\u95f4\u533a\u95f4\u5185\u4f20\u9012\u7684\u4fe1\u606f\u3002\u6b64\u5916\uff0c\u5e38\u7528\u7684\u4fe1\u606f\u8bba\u4e2d\u7684\u5ea6\u91cf\uff0c\u6bd4\u5982 transfer entropy \u7b49\uff0c\u4e3b\u8981\u8003\u8651\u7684\u662f\u4e24\u4e2a\u8fde\u7eed\u65f6\u95f4\u70b9\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u800c\u8ba1\u7b97\u6574\u6761\u65f6\u95f4\u5e8f\u5217\u52a8\u529b\u5b66\u4e2d\u5305\u542b\u7684\u4fe1\u606f\u662f\u4e00\u4e2a\u96be\u9898\u3002\u6bd4\u5982\uff0c\u6587\u732e [2]\u4e2d\u5206\u6790\u65f6\u95f4\u5e8f\u5217\u7684\u65b9\u6cd5\u53ea\u5728\u65f6\u95f4\u70b9\u8f83\u5c11\u65f6\u6709\u6548\u3002\u53e6\u4e00\u79cd\u4f7f\u7528\u673a\u5668\u5b66\u4e60\u5206\u7c7b\u5668\u7684\u65b9\u6cd5 [4]\u53ea\u80fd\u5bf9\u4e92\u4fe1\u606f\u63d0\u4f9b\u4e86\u4e00\u4e2a\u4e0b\u754c\uff0c\u56e0\u4e3a\u91c7\u7528\u7ebf\u6027\u4e3b\u6210\u5206\u7684\u5206\u7c7b\u5668\u4e0d\u80fd\u5b8c\u5168\u533a\u5206\u542b\u6709\u632f\u8361\u52a8\u529b\u5b66\u7684\u65f6\u95f4\u5e8f\u5217\u3002<\/p>\n


\u56fe2\uff1a\u91cf\u5316\u4e92\u4fe1\u606f\u7684\u4e09\u79cd\u4ee3\u8868\u6027\u65b9\u6cd5<\/p>\n

\u4e3a\u4e86\u91cf\u5316\u4fe1\u53f7\u52a8\u529b\u5b66\u4e2d\u7f16\u7801\u7684\u4e92\u4fe1\u606f\uff0c\u5e76\u8fdb\u4e00\u6b65\u63ed\u793a\u4fe1\u606f\u4f20\u9012\u5982\u4f55\u968f\u65f6\u95f4\u53d8\u5316\uff0c\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u4e2a\u8ba1\u7b97\u6846\u67b6\u6765\u91cf\u5316\u5728\u751f\u5316\u4fe1\u53f7\u52a8\u529b\u5b66\u4e2d\u7f16\u7801\u7684\u4fe1\u606f\u79ef\u7d2f\uff08\u56fe2\uff09\uff0c\u88ab\u547d\u540d\u4e3a\u52a8\u529b\u5b66\u4e92\u4fe1\u606f [5]\u3002\u8ba1\u7b97\u7ed3\u679c\u80fd\u591f\u63ed\u793a\u7ec6\u80de\u5982\u4f55\u5b9e\u65f6\u5730\u5bf9\u73af\u5883\u53d8\u5316\u505a\u51fa\u53cd\u5e94\u800c\u4f20\u9012\u7684\u4fe1\u606f\u91cf\u3002<\/p>\n

 <\/p>\n

3. \u8fd0\u7528\u673a\u5668\u5b66\u4e60\u6a21\u578b
\u91cd\u6784\u5355\u7ec6\u80de\u4fe1\u53f7\u5206\u5b50\u52a8\u529b\u5b66<\/p>\n

\u5177\u4f53\u5730\uff0c\u4e3a\u4e86\u6709\u6548\u5730\u5206\u6790\u5177\u6709\u566a\u58f0\u3001\u5f02\u8d28\u6027\u548c\u590d\u6742\u52a8\u529b\u5b66\u6784\u8c61\u7684\u65f6\u95f4\u5e8f\u5217\uff0c\u4f5c\u8005\u5229\u7528\u9690\u9a6c\u5c14\u53ef\u592b\u6a21\u578b\uff08Hidden Markov Model\uff09\u6765\u5b66\u4e60\u65f6\u95f4\u5e8f\u5217\u7684\u52a8\u529b\u5b66\u3002\u9690\u9a6c\u5c14\u53ef\u592b\u6a21\u578b\u901a\u5e38\u88ab\u5e94\u7528\u5728\u8bed\u97f3\u8bc6\u522b\u7b49\u7ecf\u5178\u673a\u5668\u5b66\u4e60\u95ee\u9898\uff0c\u800c\u672a\u66fe\u88ab\u5e94\u7528\u5230\u7684\u751f\u7269\u4e2d\u7ec6\u80de\u4fe1\u53f7\u5206\u5b50\u7684\u8868\u8fbe\u8fc7\u7a0b\u3002\u4f5c\u8005\u53d1\u73b0\u53ef\u4ee5\u901a\u8fc7\u9690\u9a6c\u5c14\u53ef\u592b\u6a21\u578b\u8fd1\u4f3c\u5730\u91cd\u6784\u5355\u7ec6\u80de\u4fe1\u53f7\u5206\u5b50\u7684\u65f6\u95f4\u5e8f\u5217\u3002\u5bf9\u4e8e\u6a21\u578b\u63a8\u65ad\uff0c\u901a\u8fc7\u6700\u5927\u671f\u671b\u7b97\u6cd5\uff0c\u6bd4\u5982 Baum-Welch \u7b97\u6cd5\uff0c\u53ef\u4ee5\u63a8\u65ad\u51fa\u6700\u4f18\u7684\u8f93\u51fa\u6982\u7387\u548c\u8f6c\u79fb\u6982\u7387\u6765\u8fd1\u4f3c\u5730\u91cd\u6784\u65f6\u95f4\u5e8f\u5217\u3002\u901a\u8fc7\u8fdb\u4e00\u6b65\u5bfb\u627e\u6700\u4f18\u7684\u9690\u53d8\u91cf\u548c\u8f93\u51fa\u53d8\u91cf\u72b6\u6001\u6570\uff0c\u6a21\u578b\u53ef\u4ee5\u5728\u6ca1\u6709\u8fc7\u62df\u5408\u7684\u60c5\u51b5\u4e0b\uff0c\u91cd\u6784\u51fa\u670980%\u5de6\u53f3\u51c6\u786e\u5ea6\u7684\u65f6\u95f4\u5e8f\u5217\u7ec4\u3002\u6bd4\u5982\uff0c\u5bf9\u4e8e\u5de8\u566c\u7ec6\u80de\u4e2d\u7684\u514d\u75ab\u5206\u5b50NFkB\u7684\u5355\u7ec6\u80de\u6570\u636e\uff08~500\u6761\uff09\uff0c\u5373\u4f7f\u662f\u5bf9\u6700\u96be\u91cd\u6784\u7684\u5177\u6709\u975e\u540c\u6b65\u9707\u8361\u7684\u65f6\u95f4\u5e8f\u5217\u7ec4\uff0c\u8bad\u7ec3\u4e00\u4e2a\u9690\u9a6c\u5c14\u53ef\u592b\u6a21\u578b\u80fd\u591f\u8fd1\u4f3c\u5730\u91cd\u6784\u51fa\u6570\u636e\uff08\u56fe3\uff09\u3002<\/p>\n


\u56fe3\uff1a\u5b9e\u9a8c\u6570\u636e\uff08\u5355\u7ec6\u80deNFkB\u5206\u5b50\u8868\u8fbe\u91cf\uff09\u548c\u9690\u9a6c\u5c14\u53ef\u592b\u6a21\u578b\u7684\u91cd\u6784<\/p>\n

 <\/p>\n

4. \u52a8\u529b\u5b66\u4e92\u4fe1\u606f\u63ed\u793a\u4e86\u7ec6\u80de\u533a\u5206\u523a\u6fc0\u7269\u7684\u6570\u91cf\u548c\u987a\u5e8f<\/p>\n

\u57fa\u4e8e\u6a21\u578b\u7684\u91cd\u6784\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u8ba1\u7b97\u4e86\u5728\u751f\u5316\u4fe1\u53f7\u52a8\u529b\u5b66\u4e2d\u7f16\u7801\u7684\u4e92\u4fe1\u606f\u3002\u5177\u4f53\u800c\u8a00\uff0c\u4f5c\u8005\u8ba1\u7b97\u4e86\u6bcf\u6761\u65f6\u95f4\u5e8f\u5217\u7684\u8f68\u8ff9\u71b5 [6]\uff0c\u4ee5\u53ca\u4fe1\u53f7\u5206\u5b50\u4e0e\u523a\u6fc0\u7269\u4e4b\u95f4\u7684\u4e92\u4fe1\u606f\u3002\u8fd9\u79cd\u5728\u8f68\u8ff9\u7a7a\u95f4\u4e2d\u8ba1\u7b97\u4e92\u4fe1\u606f\u7684\u7406\u8bba\u65b9\u6cd5\uff0c\u80fd\u591f\u7ed9\u51fa\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u79ef\u7d2f\u7684\u4fe1\u606f\uff08\u56fe4\uff09\u3002\u5bf9\u4e8e\u514d\u75ab\u53cd\u5e94\u5206\u5b50NFkB\uff0c\u52a8\u529b\u5b66\u4e92\u4fe1\u606f\u63ed\u793a\u4e86\u7ec6\u80de\u80fd\u6709\u6548\u8bc6\u522b\u523a\u6fc0\u7269\u79cd\u7c7b\u968f\u65f6\u95f4\u7684\u53d8\u5316\uff0c\u548c\u7ec6\u80de\u8bc6\u522b\u7279\u5b9a\u523a\u6fc0\u7269\uff08\u5982\u7ec6\u83cc\u548c\u75c5\u6bd2\uff09\u7684\u65f6\u95f4\u987a\u5e8f\u3002<\/p>\n

<\/div>\n

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 <\/p>\n


5. \u603b\u7ed3<\/p>\n

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\u8fd9\u5957\u8ba1\u7b97\u6846\u67b6\u666e\u904d\u9002\u7528\u4e8e\u5355\u7ec6\u80de\u65f6\u95f4\u5e8f\u5217\u6570\u636e\u5206\u6790\uff0c\u53ef\u7528\u4e8e\u5206\u6790\u7ec6\u80de\u4e2d\u4e0e\u65f6\u95f4\u76f8\u5173\u7684\u8c03\u63a7\u673a\u5236\u662f\u5982\u4f55\u4f20\u8f93\u4fe1\u606f\u7684\uff0c\u4ece\u800c\u5e2e\u52a9\u7406\u89e3\u590d\u6742\u751f\u547d\u4f53\u4e2d\u7684\u4fe1\u606f\u4f20\u9012\u8fc7\u7a0b\u3002<\/p>\n

\u8ba1\u7b97\u6846\u67b6\u4ee3\u7801\uff1a
https:\/\/github.com\/signalingsystemslab\/dMI<\/p>\n

\u4f5c\u8005\u6c64\u8fce\u5373\u5c06\u52a0\u5165\u5317\u4eac\u5e08\u8303\u5927\u5b66\u73e0\u6d77\u6821\u533a\u7684\u81ea\u7136\u79d1\u5b66\u9ad8\u7b49\u7814\u7a76\u9662\u4ece\u4e8b\u7edf\u8ba1\u7269\u7406\u548c\u590d\u6742\u7cfb\u7edf\u7684\u7814\u7a76\uff0c\u671f\u5f85\u4e0e\u76f8\u5173\u540c\u884c\u4ea4\u6d41\u5408\u4f5c\u3002\u90ae\u7bb1\uff1ajamestang23@gmail.com<\/p>\n

\u53c2\u8003\u6587\u732e
[1] X. Qiu, Q. Mao, Y. Tang, L. Wang, R. Chawla, H. A. Pliner, and C. Trapnell, Reversed Graph Embedding Resolves Complex Single-Cell Trajectories, Nature Methods 14, 979 (2017).
[2] J. Selimkhanov, B. Taylor, J. Yao, A. Pilko, J. Albeck, A. Hoffmann, L. Tsimring, and R. Wollman, Accurate Information Transmission through Dynamic Biochemical Signaling Networks, Science 346, 1370 (2014).
[3] R. Cheong, A. Rhee, C. J. Wang, I. Nemenman, and A. Levchenko, Information Transduction Capacity of Noisy Biochemical Signaling Networks, Science 334, 354 (2011).
[4] A. A. Granados, J. M. J. Pietsch, S. A. Cepeda-Humerez, I. L. Farquhar, G. Tka\u010dik, and P. S. Swain, Distributed and Dynamic Intracellular Organization of Extracellular Information, PNAS 115, 6088 (2018).
[5] Y. Tang, A. Adelaja, F. X.-F. Ye, E. Deeds, R. Wollman, and A. Hoffmann, Quantifying Information Accumulation Encoded in the Dynamics of Biochemical Signaling, Nat. Commun. 12, 1 (2021).
[6] U. Seifert, Entropy Production along a Stochastic Trajectory and an Integral Fluctuation Theorem, Phys. Rev. Lett. 95, 040602 (2005).<\/p>\n

\u7f51\u7edc\u79d1\u5b66\u65b0\u8bfe\u63a8\u8350\uff1a\u7f51\u7edc\u52a8\u529b\u5b66<\/p>\n



\u96c6\u667a\u5b66\u56ed\u7279\u9080\u9648\u5173\u8363\u3001\u9879\u6797\u82f1\u3001\u6a0a\u745b\u3001\u5ba3\u7426\u3001\u674e\u7fd4\u3001\u53f2\u5b9a\u534e\u3001\u674e\u806a\u3001\u8363\u667a\u6d77\u3001\u5468\u8fdb\u3001\u738b\u7433\u7b49\u7f51\u7edc\u79d1\u5b66\u4e13\u5bb6\u4f5c\u4e3a\u5bfc\u5e08\uff0c\u4f9d\u6258\u6c6a\u5c0f\u5e06\u3001\u674e\u7fd4\u3001\u9648\u5173\u8363\u7684\u7ecf\u5178\u6559\u6750\u300a\u7f51\u7edc\u79d1\u5b66\u5bfc\u8bba\u300b\uff0c\u81ea2\u670827\u65e5\u8d77\u5f00\u5c55\u7cfb\u5217\u4e0a\u7ebf\u8bfe\u7a0b\uff0c\u4ee5\u7f51\u7edc\u52a8\u529b\u5b66\u4e3a\u4e3b\u7ebf\u6784\u5efa\u7f51\u7edc\u79d1\u5b66\u77e5\u8bc6\u4f53\u7cfb\u3002\u6b22\u8fce\u5e0c\u671b\u8fdb\u5165\u7f51\u7edc\u79d1\u5b66\u9886\u57df\u3001\u63d0\u9ad8\u7f51\u7edc\u5206\u6790\u80fd\u529b\u3001\u4e0e\u4e00\u7ebf\u4e13\u5bb6\u63a2\u8ba8\u95ee\u9898\u7684\u670b\u53cb\u62a5\u540d\u53c2\u52a0\uff01<\/p>\n

<\/a>
\u70b9\u51fb\u67e5\u770b\u8bfe\u7a0b\u8be6\u60c5\uff1a2021\u91cd\u78c5\u65b0\u8bfe\uff1a\u63a2\u7d22\u7f51\u7edc\u52a8\u529b\u5b66\u2014\u2014\u7f51\u7edc\u79d1\u5b66\u7b2c\u4e8c\u671f<\/a><\/p>\n

\u63a8\u8350\u9605\u8bfb<\/p>\n

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\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/a><\/p>\n

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