{"id":25300,"date":"2021-04-04T16:55:00","date_gmt":"2021-04-04T08:55:00","guid":{"rendered":"https:\/\/swarma.org\/?p=25300"},"modified":"2021-04-04T16:55:00","modified_gmt":"2021-04-04T08:55:00","slug":"pnas%ef%bc%9a%e5%9c%a8%e7%94%9f%e5%8c%96%e7%bd%91%e7%bb%9c%e4%b8%ad%e8%af%86%e5%88%ab%e6%9b%b4%e5%b9%b3%e7%ad%89%e7%9a%84%e8%be%b9","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=25300","title":{"rendered":"PNAS\uff1a\u5728\u751f\u5316\u7f51\u7edc\u4e2d\u8bc6\u522b\u201c\u66f4\u5e73\u7b49\u201d\u7684\u8fb9"},"content":{"rendered":"
\n
\n
\n
\n

<\/p>\n<\/section>\n

\n
\n
\n
\n
\n
\n

<\/section>\n<\/section>\n
\n
\n

\u5bfc\u8bed<\/strong><\/p>\n<\/section>\n<\/section>\n

\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

<\/strong>\u867d\u7136\u5728\u751f\u6d3b\u4e2d\u6211\u4eec\u603b\u4f1a\u8bf4\u6bcf\u4e2a\u4eba\u90fd\u662f\u5e73\u7b49\u7684\uff0c\u4f46\u662f\u5728\u67d0\u4e9b\u7279\u5b9a\u9886\u57df\u6216\u8005\u95ee\u9898\u4e0a\uff0c\u6211\u4eec\u5fc5\u987b\u8981\u627f\u8ba4\u67d0\u4e9b\u4eba\u66f4\u4e3a\u91cd\u8981\u3002\u8fd9\u5c31\u51fa\u73b0\u4e86\u201c\u4eba\u4eba\u5e73\u7b49\u201d\uff0c\u4f46\u6709\u4e9b\u4eba\u201c\u66f4\u4e3a\u5e73\u7b49\u201d\u7684\u6709\u8da3\u73b0\u8c61\u3002\u8be5\u73b0\u8c61\u5728\u751f\u5316\u7f51\u7edc\u4e2d\u53c8\u5982\u4f55\u5462\uff1f\u8fd1\u65e5\u53d1\u8868\u5728 PNAS<\/em> \u4e0a\u7684\u4e00\u7bc7\u6587\u7ae0\u4e3a\u4e86\u66f4\u597d\u5730\u6355\u6349\u751f\u5316\u8c03\u63a7\u548c\u4fe1\u53f7\u4f20\u5bfc\u7684\u529f\u80fd\u76f8\u5173\u4fe1\u606f\uff0c\u4ece\u800c\u5f15\u5165\u6709\u6548\u56fe\uff08effective graph\uff09\u7684\u6982\u5ff5\u6765\u66f4\u597d\u5730\u7528\u4e8e\u751f\u5316\u8c03\u63a7\u3001\u4fe1\u53f7\u4f20\u9012\u7b49\u3002\u9488\u5bf9\u8fd9\u9879\u7814\u7a76\uff0cPNAS <\/em>\u8bc4\u8bba\u6587\u7ae0\u4ece\u6709\u6548\u56fe\u5fc5\u8981\u6027\u3001\u521b\u65b0\u6027\u548c\u751f\u5316\u5e94\u7528\u7b49\u65b9\u9762\u8fdb\u884c\u89e3\u8bfb\uff0c\u5e76\u5f15\u53d1\u8bfb\u8005\u5173\u4e8e\u751f\u5316\u7f51\u7edc\u8fde\u8fb9\u5e73\u7b49\u3001\u5197\u4f59\u53ca\u4ea4\u4e92\u7684\u601d\u8003\u3002<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
\n

Kishore Hari, Uday Ram, Mohit Kumar Jolly<\/span> | \u4f5c\u8005<\/strong><\/span><\/p>\n

\u80e1\u4e00\u51b0<\/span> | \u8bd1\u8005<\/strong><\/span><\/p>\n

\u5218\u57f9\u6e90<\/span> | \u5ba1\u6821<\/strong><\/span><\/strong><\/span><\/p>\n

\u9093\u4e00\u96ea<\/span> | \u7f16\u8f91<\/strong><\/span><\/span><\/p>\n<\/section>\n

<\/p>\n
\n


<\/p>\n<\/section>\n

<\/span><\/section>\n

 <\/span><\/section>\n
\u751f\u7269\u7cfb\u7edf\u7ecf\u5e38\u4f1a\u6267\u884c\u591a\u79cd\u4efb\u52a1\uff0c\u800c\u5b83\u4eec\u82e5\u60f3\u6709\u6548\u5730\u5b8c\u6210\u8fd9\u4e9b\u4efb\u52a1\u65f6\uff0c\u5b83\u4eec\u5f80\u5f80\u9762\u4e34\u7740\u591a\u91cd\u6743\u8861\u3002\u56e0\u6b64\uff0c\u751f\u7269\u7cfb\u7edf\u53ca\u5176\u7ec4\u6210\u90e8\u5206\u4f1a\u901a\u8fc7\u5927\u91cf\u7684\u8bd5\u9519\u6765\u8fbe\u5230\u6700\u4f18[1]\u3002\u8fd9\u79cd\u4f18\u5316\u7c7b\u4f3c\u4e8e\u4eba\u7c7b\u5236\u9020\u7684\u673a\u5668\u901a\u8fc7\u53cd\u590d\u8bd5\u9519\u6765\u63d0\u5347\u6b64\u7c7b\u5de5\u7a0b\u7cfb\u7edf\u7684\u6548\u7387\u3002\u7136\u800c\uff0c\u5de5\u7a0b\u7cfb\u7edf\u7684\u8fd0\u4f5c\u4e5f\u9700\u8981\u8003\u8651\u8d44\u6e90\u548c\u6210\u672c\u6548\u76ca\uff0c\u4e5f\u5c31\u662f\u8bf4\uff0c\u5de5\u7a0b\u5e08\u4f1a\u4e3b\u52a8\u4ece\u4e00\u53f0\u673a\u5668\u4e0a\u62c6\u5378\u4e0e\u6307\u5b9a\u4efb\u52a1\u65e0\u5173\u7684\u90e8\u4ef6\u3002\u90a3\u4e48\u5728\u751f\u7269\u7cfb\u7edf\u4e2d\u4e5f\u4f1a\u8fdb\u884c\u7c7b\u4f3c\u7684\u201c\u51cf\u8d1f\u201d\u5417\uff1f\u9488\u5bf9\u8fd9\u4e2a\u95ee\u9898\uff0c\u8fd1\u65e5\u5728 PNAS <\/em>\u4e2d\uff0c\u7f8e\u56fd\u4e1c\u5317\u5927\u5b66 Alexander J.Gates \u7b49\u7814\u7a76\u8005\u4eec[2]\u7ed9\u51fa\u4e86\u5426\u5b9a\u7b54\u6848\u3002\u4ed6\u4eec\u5206\u6790\u4e86\u751f\u7269\u7cfb\u7edf\u4e2d\u7684\u591a\u79cd\u8c03\u8282\u7f51\u7edc<\/span>\uff08Regulatory networks\uff09<\/span>\uff0c\u5e76\u53d1\u73b0\u6240\u6709\u8fd9\u4e9b\u7f51\u7edc\u90fd\u5305\u542b\u5197\u4f59\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u800c\u8fd9\u4e9b\u76f8\u4e92\u4f5c\u7528\u5e76\u4e0d\u76f4\u63a5\u4fc3\u8fdb\u5b83\u4eec\u6267\u884c\u7684\u7ec6\u80de\u529f\u80fd\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u751f\u7269\u7cfb\u7edf\u4e2d\u666e\u904d\u5b58\u5728\u7740\u591a\u79cd\u89c4\u6a21\u5927\u5c0f\u548c\u590d\u6742\u7a0b\u5ea6\u7684\u8c03\u8282\u7f51\u7edc\u3002\u8fd9\u4e9b\u7f51\u7edc\u4e2d\u53c8\u8574\u542b\u7740\u5404\u79cd\u751f\u7269\u5316\u5b66\u5206\u5b50\u4e4b\u95f4\u590d\u6742\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u4f8b\u5982\u7ec6\u80de\u5206\u5316\u548c\u7ec6\u80de\u5468\u671f\u8c03\u8282\uff0c\u90fd\u6765\u81ea\u4e8e\u8fd9\u6837\u5b58\u5728\u590d\u6742\u76f8\u4e92\u4f5c\u7528\u5173\u7cfb\u7684\u7f51\u7edc\u3002\u6700\u8fd1\u7684\u9ad8\u901a\u91cf<\/span>\uff08high throughput\uff09<\/span>\u6280\u672f\u7684\u8fdb\u6b65\u6709\u5229\u4e8e\u5168\u9762\u8868\u5f81\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u7684\u5404\u79cd\u7ec6\u80de\u8fc7\u7a0b\uff0c\u63ed\u793a\u76f8\u4e92\u4f9d\u5b58\u7684\u590d\u6742\u7f51\u7edc\u5173\u7cfb[3]\u3002\u8fd9\u79cd\u6d77\u91cf\u6570\u636e\u5f15\u53d1\u6982\u5ff5\u6027\u95ee\u9898\u2014\u2014\u8fd9\u4e9b\u5927\u89c4\u6a21\u7684\u4ea4\u4e92\u4f5c\u7528\u6709\u4ec0\u4e48\u7528\uff0c\u4ee5\u53ca\u7f51\u7edc\u4e2d\u6240\u6709\u7684\u8fde\u8fb9\u662f\u5426\u5728\u529f\u80fd\u6027\u4e0a\u91cd\u8981\u7a0b\u5ea6\u90fd\u662f\u5e73\u7b49\u7684\uff0c\u4f46\u6709\u4e9b\u8fb9\u6bd4\u5176\u4ed6\u8fb9\u66f4\u52a0\u5e73\u7b49\u3002<\/span><\/section>\n
 <\/span><\/section>\n
<\/section>\n

\u56fe1. \u300a\u52a8\u7269\u5e84\u56ed\u300b\u662f\u82f1\u56fd\u4f5c\u5bb6\u4e54\u6cbb\u00b7\u5965\u5a01\u5c14\u4e8e1945\u5e74\u51fa\u7248\u7684\u52a8\u7269\u5bd3\u8a00\u9898\u6750\u5c0f\u8bf4\uff0c\u8be5\u4f5c\u88ab\u516c\u8ba4\u4e3a\u53cd\u4e4c\u6258\u90a6\u653f\u6cbb\u8bbd\u55bb\u5bd3\u8a00\u3002\u8be5\u4e66\u4e2d\u7684\u7ecf\u5178\u540d\u53e5\u201cAll animals are equal, remember. But some animals are more equal than others.\u201d\uff08\u6240\u6709\u7684\u52a8\u7269\u4e00\u5f8b\u5e73\u7b49\uff0c\u4f46\u6709\u7684\u52a8\u7269\u6bd4\u5176\u4ed6\u52a8\u7269\u66f4\u5e73\u7b49\uff09\u3002<\/span><\/p>\n

 <\/span><\/section>\n
\u76ee\u524d\u6709\u5f88\u591a\u79cd\u8ba1\u7b97\u65b9\u6cd5\u88ab\u5f00\u53d1\u5e76\u5e94\u7528\u6765\u6355\u6349\u8c03\u8282\u7f51\u7edc\u7d27\u6025\u52a8\u6001\u7684\u5173\u952e\u7279\u5f81\u3002\u8fd9\u4e9b\u6a21\u578b\u901a\u5e38\u65e8\u5728\u57fa\u4e8e\u4e00\u5957\u7528\u6570\u5b66\u7b97\u5f0f\u8868\u8fbe\u3001\u53cd\u6620\u7f51\u7edc\u8282\u70b9\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u89c4\u5219\u3002\u8fd9\u7c7b\u6a21\u578b\u4e2d\u6700\u7b80\u5355\u7684\u4e00\u7c7b\u662f\u5e03\u5c14\u7f51\u7edc<\/span>\uff08Boolean networks, BNs\uff09<\/span>\u6a21\u578b[4]\u3002\u987e\u540d\u601d\u4e49\uff0c\u5728\u8fd9\u79cd\u6a21\u578b\u4e2d\uff0c\u7f51\u7edc\u4e2d\u4e00\u4e2a\u8282\u70b9\u7684\u503c\u5047\u8bbe\u53ea\u6709\u4e24\u4e2a\u72b6\u6001\uff1a0\uff08\u4f4e\uff09\u548c1\uff08\u9ad8\uff09\u3002\u8fd9\u4e9b\u89c4\u5219\u7531\u53ef\u5229\u7528\u7684\u5b9e\u9a8c\u6587\u732e\u7ed3\u5408\u800c\u6210\uff0c\u8fd9\u4e9b\u5b9e\u9a8c\u6587\u732e\u6d89\u53ca\u6240\u6709\u5f71\u54cd\u7ed9\u5b9a\u8282\u70b9\u7684\u8fb9\u7684\u7ec4\u5408\u6548\u5e94\uff0c\u8fd9\u4e9b\u5047\u8bbe\u8981\u4e48\u5f25\u8865\u4e86\u751f\u7269\u4fe1\u606f\u7684\u4e0d\u8db3\uff0c\u8981\u4e48\u6709\u52a9\u4e8e\u964d\u4f4e\u6570\u5b66\u590d\u6742\u6027[5]\u3002\u5c3d\u7ba1\u57fa\u4e8e\u8fd9\u4e9b\u7b80\u5355\u7684\u5047\u8bbe\uff0c\u5e03\u5c14\u7f51\u7edc\u5728\u534a\u4e2a\u591a\u4e16\u7eaa\u4ee5\u6765\u6210\u529f\u5730\u5e94\u7528\u4e8e\u63cf\u8ff0\u548c\u9884\u6d4b\u52a8\u6001\u5c5e\u6027\uff0c\u4f8b\u5982\u663e\u6027\u8868\u5f81\u548c\u7ec6\u80de\u5468\u671f\u63a7\u5236\u7b49[6-7]\u3002\u7136\u800c\uff0c\u5e03\u5c14\u7f51\u7edc\u4e2d\u6240\u6709\u8fb9\u90fd\u5177\u6709\u540c\u7b49\u7684\u91cd\u8981\u6027\uff0c\u800c\u5bf9\u4e8e\u7279\u5b9a\u7684\u7f51\u7edc\u62d3\u6251\u7ed3\u6784\uff0c\u67d0\u4e9b\u8fb9\u5bf9\u7f51\u7edc\u6d8c\u73b0\u4e2a\u522b\u5c5e\u6027\u7684\u8d21\u732e\u7a0b\u5ea6\u53ef\u80fd\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002\u751f\u7269\u7f51\u7edc\u5bf9\u8bb8\u591a\u7ed3\u6784\u6216\u52a8\u529b\u6270\u52a8\u975e\u5e38\u9c81\u68d2\uff0c\u4f46\u5bf9\u67d0\u4e9b\u6270\u52a8\u9ad8\u5ea6\u654f\u611f\uff0c\u56e0\u6b64\u4e0d\u540c\u7684\u72b6\u6001<\/span>\uff08\u8868\u73b0\u578b\uff09<\/span>\u5e94\u8fd0\u800c\u751f\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u751f\u7269\u7f51\u7edc\u4e2d\u5305\u542b\u67d0\u4e9b\u8fb9\u6bd4\u5176\u4ed6\u8fb9\u201c\u66f4\u4e3a\u5e73\u7b49\u201d\uff0c\u4f46\u76ee\u524d\u5e03\u5c14\u7f51\u7edc\u5efa\u6a21\u7b56\u7565\u5e76\u6ca1\u6709\u660e\u786e\u8003\u8651\u7f51\u7edc\u76f8\u4e92\u4f5c\u7528\u4e2d\u5197\u4f59\u7684\u5fc5\u8981\u6027\u548c\u5f71\u54cd\u6548\u529b\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\n
<\/section>\n

\u56fe2. \u5916\u51fa\u8d2d\u7269\u7684\u8def\u5f84\u793a\u610f\u56fe\u3002\u82e5\u2461\u8def\u6bb5\u5931\u6548\uff0c\u5219\u5c45\u6c11\u65e0\u6cd5\u62b5\u8fbe\u5546\u573a\uff0c\u5b83\u662f\u4e0d\u53ef\u66ff\u4ee3\u7684\uff1b\u82e5\u2460\u6216\u2462\u8def\u6bb5\u5931\u6548\uff0c\u5c45\u6c11\u4ecd\u53ef\u4ee5\u9009\u62e9\u66ff\u4ee3\u8def\u6bb5\u524d\u8fdb\uff0c\u4f46\u8003\u8651\u5bf9\u5e94\u7684\u66ff\u4ee3\u8def\u6bb5\u6570\u91cf\uff0c\u8fb9\u4e0d\u53ef\u66ff\u4ee3\u7a0b\u5ea6\u2460>\u2462\u3002\u672c\u8d28\u4e0a\u770b\uff0c\u6240\u6709\u8def\u6bb5\u90fd\u4f1a\u627f\u8f7d\u4e00\u5b9a\u7684\u670d\u52a1\u9700\u6c42\uff0c\u6240\u6709\u8fb9\u90fd\u662f\u201c\u5e73\u7b49\u201d\u7684\u3002\u4f46\u4ece\u5b8c\u6210\u8d2d\u7269\u76ee\u7684\u89d2\u5ea6\u6765\u770b\uff0c\u2461\u6bd4\u2460\u548c\u2462\u201c\u66f4\u4e3a\u5e73\u7b49\u201d\u3002<\/span><\/p>\n


<\/span><\/p>\n<\/section>\n

\u5197\u4f59\u53ef\u4ee5\u901a\u8fc7\u89c2\u5bdf\u751f\u7269\u5316\u5b66\u7f51\u7edc\u4e2d\u201c\u6e20\u5316\u201d<\/span>\uff08canalization\uff09<\/span>\u7684\u5b58\u5728\u6765\u8bc1\u5b9e[10]\uff0c\u53ea\u8981\u5bf9\u7f51\u7edc\u8fdb\u884c\u5c11\u91cf\u7684\u52a8\u6001\u6270\u52a8\uff0c\u5c31\u53ef\u4ee5\u6539\u53d8\u6d8c\u73b0\u7684\u7f51\u7edc\u7279\u6027[11]\u3002\u6b64\u5916\uff0c\u5c0f\u578b\u7f51\u7edc\u7ed3\u6784[12-14]\u5c31\u80fd\u591f\u6267\u884c\u591a\u79cd\u52a8\u529b\u5b66\u884c\u4e3a\uff0c\u5982\u8868\u73b0\u578b\u5207\u6362\u3001\u9002\u5e94\u3001\u8109\u51b2\u4ea7\u751f\u548c\u632f\u8361\uff0c\u8fd9\u8868\u660e\u5927\u578b\u7f51\u7edc\u7684\u80fd\u529b\u5b58\u5728\u5197\u4f59\u3002\u90a3\u6211\u4eec\u5982\u4f55\u7406\u89e3\u8fd9\u79cd\u5197\u4f59\u7684\u7a0b\u5ea6\uff0c\u5e76\u5c06\u5176\u5e94\u7528\u5728\u6211\u4eec\u7406\u89e3\u751f\u7269\u7f51\u7edc\u5e76\u5bf9\u5176\u8fdb\u884c\u6297\u6270\u9884\u6d4b\u7684\u7814\u7a76\u4e2d\u53bb\u5462\uff1f<\/span><\/section>\n
 <\/span><\/section>\n
<\/section>\n

\u56fe3. \u6709\u6548\u56fe\u8bc6\u522b\u7f51\u7edc\u76f8\u4e92\u4f5c\u7528\u4e2d\u7684\u5197\u4f59\u3002(A)\u4e09\u4e2a\u8282\u70b9\u3001\u516d\u4e2a\u8fb9\u7684\u7f51\u7edc\u6837\u672c\u3002(B)\u5bf9\u5e94\u7684\u6709\u6548\u56fe\uff0c\u6570\u503c\u8868\u793a\u6bcf\u516d\u6761\u8fb9\u7684\u6709\u6548\u6027\u5f97\u5206\u3002(C)\u67e5\u627eA\u4e2d\u7f51\u7edc\u5bf9\u5e94\u7684\u771f\u503c\u8868\u3002(D)\u8868\u5f81\u8fb9\u5bf9\u8282\u70b9A\u548cC\u7684\u6709\u6548\u6027\u3002#(\u901a\u914d\u7b26)\u8868\u793a\u8282\u70b9\u7684\u6d3b\u52a8\uff0c\u4e0d\u5f71\u54cd\u7f51\u7edc\u8f93\u51fa\u3002<\/span><\/p>\n

 <\/span><\/section>\n
Gates\u7b49\u4eba[2]\u63d0\u51fa\u4e86\u4e00\u79cd\u91cf\u5316\u5e03\u5c14\u7f51\u7edc\u4e2d\u8fd9\u79cd\u5197\u4f59\u7684\u65b9\u6cd5\u3002\u7b80\u5355\u5730\u8bf4\uff0c\u4ed6\u4eec\u7684\u65b9\u6cd5\u79f0\u4e3a\u201c\u6709\u6548\u56fe\u201d<\/span>\uff08effective graph\uff09<\/span>\uff0c\u4f7f\u7528\u5e03\u5c14\u7f51\u7edc\u67e5\u771f\u503c\u8868<\/span>\uff08\u5982\u56fe1\uff09<\/span>\u6765\u91cf\u5316\u8f93\u5165\u8282\u70b9\u7684\u6d3b\u52a8<\/span>\uff08\u4ee5\u53ca\u76f8\u5e94\u7684\u8fb9\u6cbf\uff09<\/span>\u5bf9\u76f8\u5e94\u76ee\u6807\u8282\u70b9\u72b6\u6001\u7684\u5f71\u54cd\u3002\u4ed6\u4eec\u4e3a\u4ece\u4e00\u4e2a\u8d77\u70b9\u5230\u4e00\u4e2a\u7ec8\u70b9\u7684\u6bcf\u6761\u8fb9\u6253\u5206\u2014\u2014\u79f0\u4e3a\u201c\u8fb9\u6709\u6548\u6027\u201d\uff0c\u5206\u503c\u4ece0\u52301\uff0c\u5176\u4e2d0\u8868\u793a\u5b8c\u5168\u591a\u4f59\u7684\u8fb9<\/span>\uff08\u56e0\u6b64\u53ef\u4ee5\u5728\u4e0d\u5e72\u6270\u7f51\u7edc\u52a8\u529b\u5b66\u7684\u60c5\u51b5\u4e0b\u5220\u9664\uff09<\/span>\uff0c1\u662f\u5fc5\u987b\u5b58\u5728\u7684\u8fb9\u3002\u56e0\u6b64\uff0c\u6709\u6548\u56fe\u53ef\u4ee5\u77e5\u9053\u5728\u67d0\u4e2a\u7f51\u7edc\u67d0\u6761\u8fb9\u662f\u5426\u662f\u5b8c\u5168\u6216\u51e0\u4e4e\u5b8c\u5168\u5197\u4f59\uff0c\u4e5f\u53ef\u4ee5\u7528\u4e8e\u8bc6\u522b\u6a21\u5757\u7ed3\u6784<\/span>\uff08\u4e00\u7ec4\u8282\u70b9\u5728\u7f51\u7edc\u4e2d\u76f8\u4e92\u8054\u7cfb\u7d27\u5bc6\uff0c\u4f46\u76f8\u5bf9\u5176\u4ed6\u8282\u70b9\u8054\u7cfb\u8f83\u5f31\uff09<\/span>\uff0c\u8fd8\u89e3\u91ca\u6270\u52a8\u5982\u4f55\u4ece\u67d0\u4e2a\u8282\u70b9<\/span>\uff08\u6bd4\u5982\u836f\u7269\u6cbb\u7597\uff09<\/span>\u6e17\u900f\u8fdb\u5168\u7f51\u7edc\uff0c\u6700\u7ec8\u5f71\u54cd\u7ec6\u80de\u529f\u80fd\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\uff0c\u7814\u7a76\u8005\u4eec\u5c06\u5927\u91cf\u4e0d\u540c\u89c4\u6a21\u548c\u590d\u6742\u7a0b\u5ea6\u7684\u5e03\u5c14\u7f51\u8def\u4e2d\u8fb9\u7684\u6709\u6548\u6027\u5c5e\u6027\u5316\uff0c\u5e76\u53d1\u73b0\u6240\u6709\u8fd9\u4e9b\u7f51\u7edc\u81f3\u5c11\u6709\u4e00\u4e2a\u5b8c\u5168\u5197\u4f59\u7684\u8fb9\u3002\u4f8b\u5982\uff0c\u5220\u9664\u81f3\u5c11\u4e00\u4e2a\u8fb9\u4e0d\u4f1a\u5e72\u6270\u7f51\u7edc\u4e0a\u7684\u52a8\u529b\u5b66\u6216\u751f\u7269\u529f\u80fd\u3002\u6709\u8da3\u7684\u662f\uff0c\u7814\u7a76\u8005\u4eec\u89c2\u5bdf\u5230\uff0c\u8fd9\u4e9b\u5e03\u5c14\u7f51\u7edc\u8fb9\u7684\u5e73\u5747\u6709\u6548\u5ea6\u660e\u663e\u5c0f\u4e8e\u968f\u673a\u6784\u5efa\u7684\u201c\u5047\u8bbe\u201d\u7f51\u7edc<\/span>\uff08\u5373\u5e73\u5747\u5197\u4f59\u7a0b\u5ea6\u66f4\u5927\uff09<\/span>\u3002\u8fd9\u4e9b\u89c2\u5bdf\u8868\u660e\uff0c\u5197\u4f59\u5728\u751f\u7269\u7f51\u7edc\u4e2d\u662f\u666e\u904d\u5b58\u5728\u7684\uff0c\u5e76\u4e14\u53ef\u80fd\u5df2\u7ecf\u88ab\u8fdb\u5316\u6240\u9009\u62e9\u3002\u8be5\u9879\u76ee\u63d0\u51fa\u4e86\u8fd9\u79cd\u5e03\u5c14\u7f51\u7edc\u7684\u7ed3\u6784\u5197\u4f59\u4f5c\u4e3a\u4e00\u79cd\u758f\u5bfc\u673a\u5236\uff0c\u53ea\u6709\u6709\u9650\u7684\u6270\u52a8\u96c6<\/span>\uff08\u9488\u5bf9\u7f51\u7edc\u4e2d\u7684\u7279\u5b9a\u8fb9\u6216\u8282\u70b9\uff09<\/span>\u624d\u80fd\u6539\u53d8\u7f51\u7edc\u52a8\u6001\u3002\u5b83\u4eec\u6709\u529b\u5730\u8bc1\u660e\u4e86\u6709\u6548\u56fe\u6bd4\u6574\u4e2a\u4ea4\u4e92\u56fe<\/span>\uff08interaction graph\uff09<\/span>\u80fd\u66f4\u597d\u5730\u9884\u6d4b\u6270\u52a8\u7684\u7ed3\u679c\u3002\u56e0\u6b64\uff0c\u6709\u6548\u56fe\u53ef\u80fd\u5728\u8bc6\u522b\u8c03\u8282\u7f51\u7edc\u7684\u201c\u963f\u57fa\u91cc\u65af\u4e4b\u8e35\u201d\u65b9\u9762\u63d0\u4f9b\u66f4\u591a\u4fe1\u606f\u3002\u8fd9\u8ba9\u4eba\u4e0d\u7981\u60f3\u8d77\u53e6\u4e00\u79cd\u7f51\u7edc\u7b80\u5316\u65b9\u6cd5\uff0c\u901a\u8fc7\u5f97\u5230\u7279\u5b9a\u7f51\u7edc\u7684\u201c\u5f71\u54cd\u77e9\u9635\u201d<\/span>\uff08influence matrix\uff09<\/span>\u6765\u8861\u91cf\u5404\u4e2a\u8282\u70b9\u4e4b\u95f4\u7684\u4f5c\u7528\u7a0b\u5ea6[15]\u3002<\/span><\/section>\n
 <\/span><\/section>\n
<\/section>\n

\u56fe4. \u201c\u5f71\u54cd\u77e9\u9635\u201d\uff0c\u53ef\u7528\u6765\u91cf\u5316\u8282\u70b9\u5bf9\u5176\u4ed6\u8282\u70b9\u7684\u5f71\u54cd\uff0c\u53d6\u503c\u8303\u56f4\u4ece-1\u52301\uff0c\u8be6\u89c1\u53c2\u8003\u6587\u732e[15]\u3002<\/span><\/p>\n

 <\/span><\/section>\n
Gates \u7b49\u4eba[2]\u63d0\u51fa\u7684\u6709\u6548\u56fe\u5728\u6982\u5ff5\u4e0a\u4e0e\u4ee3\u8c22\u7f51\u7edc\u4e2d\u89c2\u5bdf\u5230\u7684\u529f\u80fd\u5197\u4f59\u76f8\u4f3c\uff0c\u4ee3\u8c22\u901a\u91cf<\/span>\uff08metabolic flux\uff09<\/span>\u53ef\u4ee5\u5229\u7528\u7f51\u7edc\u4e2d\u7684\u8bb8\u591a\u8def\u5f84\u3002\u8fd9\u6837\u7684\u5197\u4f59\u4f7f\u5f97\u65b0\u9648\u4ee3\u8c22\u5bf9\u8bb8\u591a\u81f4\u547d\u7684\u5e72\u6270\u90fd\u5f88\u9c81\u68d2[16]\u3002\u5229\u7528\u6709\u6548\u56fe\uff0c\u4f5c\u8005\u5efa\u8bae\u8bc6\u522b\u51fa\u6700\u80fd\u4ee3\u8868\u4ece\u65e0\u6570\u8f93\u5165\u4fe1\u53f7\u5230\u6709\u9650\u8f93\u51fa\u8868\u73b0\u578b\u7684\u4fe1\u606f\u6d41\u7684\u63a7\u5236\u8def\u5f84\u3002\u8fd9\u4e9b\u8def\u5f84\u53ef\u4ee5\u5f15\u5bfc\u6211\u4eec\u5c1d\u8bd5\u786e\u5b9a\u75c5\u7406\u60c5\u51b5\u4e0b\uff0c\u80fd\u7834\u574f\u6f5c\u5728\u7684\u63a7\u5236\u7ed3\u6784\u6cbb\u7597\u7b56\u7565\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u901a\u8fc7\u4f7f\u7528\u6f5c\u5728\u7684\u4fe1\u53f7\u7f51\u7edc\u51b3\u5b9a\u7ec6\u80de\u662f\u5426\u4f1a\u53d1\u751f\u51cb\u4ea1\u6216\u589e\u6b96\u7684ER+\u4e73\u817a\u764c\u6848\u4f8b\u7814\u7a76\u8bc1\u660e\u4e86\u8be5\u65b9\u6cd5\u7684\u6709\u6548\u6027\u3002\u5bf9\u5197\u4f59\u8fb9\u7684\u8bc6\u522b\u548c\u5220\u9664\u5bfc\u81f4\u7f51\u7edc\u88ab\u5206\u5272\u6210\u4e0d\u540c\u7684\u6a21\u5757\u3002\u8fd9\u4e9b\u6a21\u5757\u4e0d\u4ec5\u8bc6\u522b\u4e86\u7f51\u7edc\u4e2d\u7684\u5404\u79cd\u63a7\u5236\u8def\u5f84\uff0c\u800c\u4e14\u8fd8\u8868\u660e\uff0c\u4ece\u4fe1\u53f7\u5230\u8282\u70b9\u7684\u53ef\u8fbe\u6027\u8fdc\u4f4e\u4e8e\u4ea4\u4e92\u56fe\u8bc6\u522b\u7684\u53ef\u8fbe\u6027\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u4e2a\u4f53\u6270\u52a8\u5728\u5f71\u54cd\u7ec6\u80de\u52a8\u529b\u5b66\u65b9\u9762\u53ef\u80fd\u4e0d\u50cf\u9ed8\u8ba4\u5047\u8bbe\u7684\u90a3\u4e48\u6709\u6548\u3002\u8fd9\u4e9b\u5bf9\u7f51\u7edc\u62d3\u6251\u7ed3\u6784\u7684\u6d1e\u89c1\u63ed\u793a\u4e86\u8bb8\u591a\u8def\u5f84\u8868\u73b0\u51fa\u5bf9\u81f4\u547d\u5e72\u6270\u7684\u627f\u53d7\u529b\uff0c\u81f3\u5c11\u8bb8\u591a\u81f4\u547d\u7ed3\u679c\u662f\u56e0\u4e3a\u5b50\u6a21\u5757\u5206\u88c2\u5bfc\u81f4\u3002\u56e0\u6b64\u53ef\u77e5\uff0c\u5b9e\u9645\u4e2d\u9700\u8981\u591a\u79cd\u6cbb\u7597\u6270\u52a8\u6765\u51cf\u5c11\u764c\u75c7\u7684\u6570\u91cf\u3002<\/span><\/section>\n
 <\/span><\/section>\n
<\/section>\n

\u56fe5. \u9488\u5bf9ER+\u4e73\u817a\u764cBN\u6a21\u578b\u7684\u7814\u7a76\u3002A\u4e3aER+\u4e73\u817a\u764c\u7684BN\u6a21\u578b\u6709\u6548\u56fe\u7684\u5206\u5c42\u7ed8\u5236\uff0cB\u4e3a\u6761\u4ef6\u6709\u6548\u56fe\uff0cC\u4e3a\u6270\u52a8\u5bf9\u6a21\u578b\u4e2d7\u79cd\u836f\u7269\u5404\u81ea\u7684\u6269\u6563\u52a8\u529b\u5b66\u548c\u7f51\u7edc\u6709\u6548\u53ef\u8fbe\u6bd4\u4f8b\uff0cD\u4e3a\u836f\u7269\u53d8\u91cf\u51fa\u8fb9\u7684\u6709\u6548\u6027<\/span><\/p>\n

 <\/span><\/section>\n
\u8003\u8651\u5230\u6240\u5f00\u53d1\u65b9\u6cd5\u7684\u53ef\u6269\u5c55\u6027\uff0c\u8be5\u65b9\u6cd5\u53ef\u7528\u4e8e\u8bc6\u522b\u6709\u6548\u7279\u5f81\uff0c\u5b83\u53ef\u4ee5\u8f85\u52a9\u5404\u79cd\u7f51\u7edc\u8fd8\u539f\u7b56\u7565\uff0c\u8fd9\u4e9b\u7b56\u7565\u901a\u5e38\u4ee5\u4fdd\u7559\u7f51\u7edc\u7684\u7d27\u6025\u7279\u6027\u4e3a\u76ee\u6807\uff0c\u6700\u5e38\u89c1\u7684\u7b56\u7565\u662f\u7f51\u7edc\u542f\u7528\u7684\u5438\u5f15\u5b50<\/span>\uff08\u6216\u8868\u73b0\u578b\uff09<\/span>[17]\u3002\u6709\u6548\u56fe\u57fa\u4e8e\u67e5\u627e\u771f\u503c\u8868\u7684\u7ed3\u679c\u5bf9\u7f51\u7edc\u8fdb\u884c\u7b80\u5316\uff0c\u4fdd\u8bc1\u4e86\u5438\u5f15\u5b50\u7684\u5b88\u6052\u6027\u3002\u6b64\u5916\uff0c\u5b83\u8fd8\u63d0\u4f9b\u4e86\u5173\u4e8e\u7b80\u5316\u7f51\u7edc\u7684\u8fde\u901a\u7a0b\u5ea6\u7684\u4fe1\u606f\u3002\u867d\u7136\u7b80\u5316\u7684\u7f51\u7edc\u8868\u793a\u65b9\u6cd5\uff0c\u5305\u62ec\u6709\u6548\u56fe\uff0c\u5df2\u7ecf\u80fd\u591f\u89e3\u91ca\u5404\u79cd\u5b9e\u9a8c\u73b0\u8c61\uff0c\u4f46\u5b83\u4eec\u5b9e\u73b0\u975e\u76f4\u89c2\u6216\u975e\u7410\u788e\u7684\u9884\u6d4b\u7684\u80fd\u529b\u5e76\u8fbe\u5230\u9884\u671f\u7ed3\u679c<\/span>\uff08\u4f8b\u5982\u51cf\u5c11\u764c\u7ec6\u80de\u6570\u91cf\uff09<\/span>\u53d6\u51b3\u4e8e\u7ec4\u5408\u6216\u987a\u5e8f\u7684\u5e72\u6270\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u4ece\u6982\u5ff5\u4e0a\u8bb2\uff0c\u6709\u6548\u56fe\u6cd5\u975e\u5e38\u6709\u7528\uff0c\u5e94\u8be5\u53ef\u4ee5\u88ab\u5e7f\u6cdb\u4f7f\u7528\u3002\u7136\u800c\uff0c\u6211\u4eec\u9700\u8981\u5bf9\u4e00\u4e9b\u56fa\u6709\u5047\u8bbe\u4fdd\u6301\u8c28\u614e\u3002\u6709\u6548\u56fe\u7684\u63a8\u7406\u5b8c\u5168\u4f9d\u8d56\u4e8e\u7528\u4e8e\u5f00\u53d1\u4e0a\u8ff0\u5e03\u5c14\u7f51\u7edc\u7684\u89c4\u5219\uff0c\u800c\u8fd9\u4e9b\u89c4\u5219\u4f1a\u968f\u7740\u4e0d\u65ad\u589e\u52a0\u7684\u5b9e\u9a8c\u8981\u6c42\u800c\u6539\u53d8\u3002\u8fd9\u79cd\u4f9d\u8d56\u6027\u53ef\u80fd\u4f1a\u963b\u788d\u8fd9\u4e9b\u7ed3\u679c\u7684\u63a8\u5e7f\uff0c\u4f46\u662f\u5728\u751f\u7269\u7cfb\u7edf\u4e2d\u91cd\u590d\u7684\u6e20\u5316\u758f\u5bfc\u53ef\u4ee5\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\u3002\u6b64\u5916\uff0c\u5b9a\u4e49\u7279\u5b9a\u7ec6\u80de\u7cfb\u6216\u73af\u5883\u7279\u5f02\u6027\u6709\u6548\u56fe\uff0c\u5bf9\u7c7b\u4f3c\u4e8e\u8bd5\u56fe\u5b9a\u4e49\u764c\u4e0e\u8089\u7624\u7684\u8c03\u63a7\u7f51\u7edc[18]\u53ef\u80fd\u4f1a\u6709\u6240\u5e2e\u52a9\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u4e00\u4e2a\u91cd\u8981\u7684\u6982\u5ff5\u6027\u95ee\u9898\u5728\u6b64\u4ecd\u6709\u5f85\u56de\u7b54\uff1a\u662f\u4ec0\u4e48\u673a\u5236\u5bfc\u81f4\u4e86\u5982\u6b64\u5e7f\u6cdb\u7684\u5197\u4f59\uff1f\u591a\u79cd\u56e0\u7d20\u53ef\u80fd\u4f1a\u6709\u5f71\u54cd\uff0c\u4f8b\u5982\uff081\uff09\u57fa\u4e8e\u5b9e\u9a8c\u7684\u7f51\u7edc\u7ba1\u7406\u9519\u8bef\uff1b\uff082\uff09\u5728\u8fdb\u5316\u65f6\u95f4\u5c3a\u5ea6\u4e0a\u7684\u7f51\u7edc\u526a\u679d\u201c\u53cd\u590d\u8bd5\u9a8c\u201d\u4ee5\u53ca\uff083\uff09\u8fd9\u4e9b\u5197\u4f59\u90e8\u5206\u5177\u6709\u8fc4\u4eca\u672a\u88ab\u8bc6\u522b\u7684\u529f\u80fd\u3002\u65e0\u8bba\u539f\u56e0\u662f\u4ec0\u4e48\uff0c\u8981\u56de\u7b54\u4e3a\u4ec0\u4e48\u751f\u7269\u7f51\u7edc\u4e2d\u7684\u67d0\u4e9b\u8fde\u8fb9\u53ef\u80fd\u201c\u6bd4\u5176\u4ed6\u8fde\u8fb9\u66f4\u5e73\u7b49\u201d\uff0c\u8fd9\u7edd\u5bf9\u662f\u4e00\u6bb5\u6709\u8da3\u7684\u63a2\u7d22\u4e4b\u65c5\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u539f\u6587\u5730\u5740\uff1a<\/span><\/section>\n
https:\/\/www.pnas.org\/content\/118\/16\/e2103698118<\/span><\/section>\n
 <\/span><\/section>\n
\n
\n
\n

\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n


<\/p>\n

[1] O. Shoval et al., Evolutionary trade-offs, Pareto optimality, and the geometry of phenotype space. Science 336, 1157\u20131160 (2012).<\/span><\/section>\n
[2] A. J. Gates, R. Brattig Correia, X. Wang, L. M. Rocha, The effective graph reveals redundancy, canalization, and control pathways in biochemical regulation and signaling.Proc. Natl. Acad. Sci. U.S.A.118,e2022598118 (2021).<\/span><\/section>\n
[3] M. M. Saint-Antoine, A. Singh, Network inference in systems biology: Recent developments, challenges, and applications. Curr. Opin. Biotechnol. 63, 8 9\u201398<\/span><\/section>\n
(2020).<\/span><\/section>\n
[4] J. D. Schwab, S. D. K\u00fchlwein, N. Ikonomi, M. K\u00fchl, H. A. Kestler, Concepts in Boolean network modeling: What do they all mean? Comput. Struct. Biotechnol. J.18, 571\u2013582 (2020).<\/span><\/section>\n
[5] F. Font-Clos, S. Zapperi, C. A. M. La Porta, Topography of epithelial mesenchymal plasticity. Proc. Natl. Acad. Sci. U.S.A. 115, 5902\u20135907 (2018).<\/span><\/section>\n
[6] R. S. Wang, A. Saadatpour, R. Albert, Boolean modeling in systems biology: An overview of methodology and applications. Phys. Biol. 9, 055001 (2012).<\/span><\/section>\n
[7] S. Bornholdt, Boolean network models of cellular regulation: Prospects and limitations. J. R. Soc. Interface 5 (suppl. 1), S85\u2013S94 (2008).<\/span><\/section>\n
[8] K. Hari et al., Identifying inhibitors of epithelial-mesenchymal plasticity using a network topology-based approach. NPJ Syst. Biol. Appl. 6, 15 (2020).<\/span><\/section>\n
[9] R. B. Correia, A. J. Gates, X. Wang, L. M. Rocha, CANA: A Python package for quantifying control and canalization in Boolean Networks. Front. Physiol. 9, 1046<\/span><\/section>\n
(2018).<\/span><\/section>\n
[10] C. H. Waddington, Canalization of development and genetic assimilation of acquired characters. Nature 183, 1654\u20131655 (1959).<\/span><\/section>\n
[11] M. L. Siegal, A. Bergman, Waddington\u2019s canalization revisited: Developmental stability and evolution. Proc. Natl. Acad. Sci. U.S.A. 99, 10528\u201310532 (2002).<\/span><\/section>\n
[12] U. Alon, Network motifs: Theory and experimental approaches. Nat. Rev. Genet. 8, 450\u2013461 (2007).<\/span><\/section>\n
[13] D. Jia et al., Quantifying cancer epithelial-mesenchymal plasticity and its association with stemness and immune response. J. Clin. Med. 8, 725 (2019).<\/span><\/section>\n
[14] W. Ma, A. Trusina, H. El-Samad, W. A. Lim, C. Tang, Defining network topologies that can achieve biochemical adaptation. Cell 138, 760\u2013773 (2009).<\/span><\/section>\n
[15] L. Chauhan, U. Ram, K. Hari, M. K. Jolly, Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer. Elife 10,10.7554\/eLife.64522 (2021).<\/span><\/section>\n
[16] G. Sambamoorthy, K. Raman, Understanding the evolution of functional redundancy in metabolic networks. Bioinformatics 34, i981\u2013i987 (2018).<\/span><\/section>\n
[17] J. G. T. Za~nudo, R. Albert, An effective network reduction approach to find the dynamical repertoire of discrete dynamic networks. Chaos 23, 025111(2013).<\/span><\/section>\n
[18] J. A. Somarelli et al., Mesenchymal-epithelial transition in sarcomas is controlled by the combinatorial expression of microRNA 200s and GRHL2. Mol. Cell. Biol.36, 2503\u20132513 (2016).<\/span><\/section>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n

\uff08\u53c2\u8003\u6587\u732e\u53ef\u4e0a\u4e0b\u6ed1\u52a8<\/strong>\u67e5\u770b\uff09<\/p>\n<\/section>\n<\/section>\n


<\/section>\n

<\/section>\n
\n
\n
\n
\n

\u7f51\u7edc\u79d1\u5b66\u65b0\u8bfe\u63a8\u8350\uff1a\u7f51\u7edc\u52a8\u529b\u5b66<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n


<\/section>\n

\n


<\/p>\n<\/section>\n

\u96c6\u667a\u5b66\u56ed\u7279\u9080\u9648\u5173\u8363\u3001\u9879\u6797\u82f1\u3001\u6a0a\u745b\u3001\u5ba3\u7426\u3001\u674e\u7fd4\u3001\u53f2\u5b9a\u534e\u3001\u674e\u806a\u3001\u8363\u667a\u6d77\u3001\u5468\u8fdb\u3001\u738b\u7433\u7b49\u7f51\u7edc\u79d1\u5b66\u4e13\u5bb6\u4f5c\u4e3a\u5bfc\u5e08\uff0c\u4f9d\u6258\u6c6a\u5c0f\u5e06\u3001\u674e\u7fd4\u3001\u9648\u5173\u8363\u7684\u7ecf\u5178\u6559\u6750\u300a\u7f51\u7edc\u79d1\u5b66\u5bfc\u8bba\u300b\uff0c\u81ea2\u670827\u65e5\u8d77\u5f00\u5c55\u7cfb\u5217\u4e0a\u7ebf\u8bfe\u7a0b\uff0c\u4ee5\u7f51\u7edc\u52a8\u529b\u5b66\u4e3a\u4e3b\u7ebf\u6784\u5efa\u7f51\u7edc\u79d1\u5b66\u77e5\u8bc6\u4f53\u7cfb\u3002\u6b22\u8fce\u5e0c\u671b\u8fdb\u5165\u7f51\u7edc\u79d1\u5b66\u9886\u57df\u3001\u63d0\u9ad8\u7f51\u7edc\u5206\u6790\u80fd\u529b\u3001\u4e0e\u4e00\u7ebf\u4e13\u5bb6\u63a2\u8ba8\u95ee\u9898\u7684\u670b\u53cb\u62a5\u540d\u53c2\u52a0\uff01<\/span><\/section>\n

<\/section>\n

<\/span><\/a><\/p>\n


<\/section>\n

\u70b9\u51fb\u67e5\u770b\u8bfe\u7a0b\u8be6\u60c5<\/span>\uff1a<\/span><\/p>\n

\n

2021\u91cd\u78c5\u65b0\u8bfe\uff1a\u63a2\u7d22\u7f51\u7edc\u52a8\u529b\u5b66\u2014\u2014\u7f51\u7edc\u79d1\u5b66\u7b2c\u4e8c\u671f<\/a><\/strong><\/p>\n<\/section>\n


<\/p>\n


<\/p>\n

\n

\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong>
<\/p>\n