{"id":26050,"date":"2021-05-08T21:34:30","date_gmt":"2021-05-08T13:34:30","guid":{"rendered":"https:\/\/swarma.org\/?p=26050"},"modified":"2021-05-08T21:34:30","modified_gmt":"2021-05-08T13:34:30","slug":"%e5%9f%ba%e4%ba%8e%e8%ae%a1%e7%ae%97%e5%ad%a6%e6%96%b9%e6%b3%95%e7%9a%84%e8%9b%8b%e7%99%bd%e8%b4%a8%e7%9b%b8%e4%ba%92%e4%bd%9c%e7%94%a8%e9%a2%84%e6%b5%8b%e7%bb%bc%e8%bf%b0","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=26050","title":{"rendered":"\u57fa\u4e8e\u8ba1\u7b97\u5b66\u65b9\u6cd5\u7684\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u9884\u6d4b\u7efc\u8ff0"},"content":{"rendered":"
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DrugAI <\/span>| \u6765\u6e90<\/strong><\/span><\/p>\n


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A survey on computational models for predicting protein-protein interactions<\/span><\/h1>\n

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\u9664\u4e86\u4e0a\u8ff0\u7684\u4e00\u7ea7\u7ed3\u6784\u5916\uff0c\u86cb\u767d\u8d28\u8fd8\u6709\u4e8c\u7ea7\u3001\u4e09\u7ea7\u548c\u56db\u7ea7\u4e09\u4e2a\u66f4\u9ad8\u7ea7\u7684\u7ed3\u6784\uff0c\u5b83\u4eec\u90fd\u662f\u7531\u4e00\u7ea7\u7ed3\u6784\u51b3\u5b9a\u7684\u86cb\u767d\u8d28\u7684\u7a7a\u95f4\u7ed3\u6784\u3002\u5728\u4e00\u7ea7\u7ed3\u6784\u5e8f\u5217\u4e2d\uff0c\u86cb\u767d\u8d28\u80bd\u94fe\u662f\u76f4\u94fe\u72b6\uff0c\u800c\u4e8c\u7ea7\u7ed3\u6784\u4e2d\u7684\u80bd\u94fe\u5206\u5b50\u4f1a\u901a\u8fc7\u4e00\u5b9a\u7684\u89c4\u5f8b\u8fdb\u884c\u5377\u66f2\u6216\u6298\u53e0\u5f62\u6210\u7684\u7279\u5b9a\u7a7a\u95f4\u7ed3\u6784\uff0c\u5982\u03b1\u87ba\u65cb\u548c\u03b2\u6298\u53e0\uff1b\u4e09\u7ea7\u7ed3\u6784\u662f\u5728\u4e8c\u7ea7\u7ed3\u6784\u7684\u57fa\u7840\u4e0a\u8fdb\u4e00\u6b65\u76d8\u66f2\u6216\u6298\u53e0\u5f62\u6210\u7684\u4e09\u7ef4<\/span>\uff083D\uff09<\/span>\u7a7a\u95f4\u7ed3\u6784\uff1b\u56db\u7ea7\u7ed3\u6784\u5219\u662f\u5177\u6709\u4e24\u6761\u6216\u4e24\u6761\u4ee5\u4e0a\u4e09\u7ea7\u7ed3\u6784\u7684\u591a\u80bd\u94fe\u7ec4\u6210\u7684\u86cb\u767d\u8d28\u3002\u5176\u4e2d\u6700\u5e38\u88ab\u7528\u4e8e\u9884\u6d4b\u7684\u662f\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\u7ed3\u6784\uff0c\u8be5\u4fe1\u606f\u53ef\u4ee5\u4ecePDB\u548cSCOP\u83b7\u5f97\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u57fa\u56e0\u7ec4\u4fe1\u606f\u6570\u636e\u5e93<\/span><\/strong><\/p>\n


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\u7531\u4e8e\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6280\u672f\u7684\u9ad8\u901f\u53d1\u5c55\uff0c\u591a\u79cd\u73b0\u8c61\u5982\uff1a\u57fa\u56e0\u878d\u5408\u3001\u57fa\u56e0\u90bb\u63a5\u548c\u7cfb\u7edf\u53d1\u80b2\u56fe\u8c31\u53ef\u4ee5\u88ab\u5f88\u597d\u7684\u89c2\u5bdf\u5230\uff0c\u800c\u8fd9\u4e9b\u4fe1\u606f\u5df2\u88ab\u591a\u9879\u7814\u7a76\u8bc1\u660e\u53ef\u7528\u4e8e\u9884\u6d4b\u86cb\u767d\u8d28\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u6b64\u7c7b\u4fe1\u606f\u53ef\u5728MIPS\u548cCGD\u6570\u636e\u5e93\u4e2d\u83b7\u5f97\uff0c\u524d\u8005\u66f4\u591a\u7684\u662f\u54fa\u4e73\u52a8\u7269\u76f8\u5173\u7684\u57fa\u56e0\u4fe1\u606f\uff0c\u540e\u8005\u5305\u62ec\u5176\u4ed6\u591a\u79cd\u751f\u7269\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u57fa\u56e0\u672c\u4f53\u8bba\u6570\u636e\u5e93<\/span><\/strong><\/p>\n


<\/span><\/p>\n

\u57fa\u56e0\u672c\u4f53\u8bba<\/span>\uff08Gene Ontology\uff0cGO\uff09<\/span>\u662f\u7528\u4e8e\u63cf\u8ff0\u57fa\u56e0\u53ca\u5176\u4ea7\u7269\u7684\u529f\u80fd\u548c\u8054\u7cfb\u7684\uff0c\u800c\u86cb\u767d\u8d28\u5c31\u662f\u5e38\u89c1\u7684\u57fa\u56e0\u4ea7\u7269\uff0c\u57fa\u56e0\u672c\u4f53\u8bba\u5305\u62ec\u4e09\u90e8\u5206\uff1a\u7ec6\u80de\u6210\u5206\u3001\u5206\u5b50\u529f\u80fd\u548c\u751f\u7269\u5b66\u8fc7\u7a0b\u3002\u76f8\u5173\u4fe1\u606f\u53ef\u4ee5\u4eceGO database\u548cQuickGO\u4e2d\u4e0b\u8f7d\u3002<\/span><\/p>\n


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\u8ba1\u7b97\u5b66\u9884\u6d4b\u6a21\u578b<\/strong><\/strong><\/span><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n

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\u6211\u4eec\u5c06\u4ecb\u7ecd\u8ba1\u7b97\u5b66\u9884\u6d4b\u6a21\u578b\u7684\u4e03\u5927\u79cd\u7c7b\uff0c\u5e76\u5206\u6790\u5b83\u4eec\u7684\u4f18\u7f3a\u70b9\uff0c\u5305\u62ec\uff1a\u57fa\u4e8e\u7f51\u7edc\u7684\u6a21\u578b\u3001\u57fa\u4e8e\u5e8f\u5217\u7684\u6a21\u578b\u3001\u57fa\u4e8e\u7ed3\u6784\u7684\u6a21\u578b\u3001\u57fa\u4e8e\u57fa\u56e0\u7ec4\u7684\u6a21\u578b\u3001\u57fa\u4e8e\u57fa\u56e0\u672c\u4f53\u8bba\u7684\u6a21\u578b\u3001\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u6a21\u578b\u548c\u5927\u89c4\u6a21\u9884\u6d4b\u6a21\u578b\u3002<\/span><\/p>\n<\/section>\n

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\u57fa\u4e8e\u7f51\u7edc\u7ed3\u6784\u7684\u6a21\u578b<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

\u4e00\u822c\u800c\u8a00\uff0c\u57fa\u4e8e\u7f51\u7edc\u7ed3\u6784\u7684\u9884\u6d4b\u6a21\u578b\u4f1a\u628a\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u770b\u4f5c\u56fe\u8bba\u4e2d\u7684\u65e0\u6743\u65e0\u5411\u56fe\uff0c\u8bb0\u4f5c\uff0c\u5176\u4e2d\uff0c\u662f\u4e2a\u86cb\u767d\u8d28\u7684\u96c6\u5408\uff0c\u662f\u4e2d\u4e00\u4e2a\u7684\u90bb\u63a5\u77e9\u9635\u3002\u7ed9\u5b9a\u4e24\u4e2a\u86cb\u767d\u8d28\u548c\uff0c\u5982\u679c\u548c\u5177\u6709\u76f8\u4e92\u4f5c\u7528\uff0c\u5219\uff0c\u5426\u5219\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd9\u7c7b\u6a21\u578b\u80fd\u591f\u5206\u6790\u7f51\u7edc\u4e2d\u6f5c\u5728\u7684\u7ed3\u6784\u4fe1\u606f\uff0c\u7136\u540e\u5229\u7528\u4e0d\u540c\u7684\u7ed3\u6784\u4fe1\u606f\u548c\u5ea6\u91cf\u65b9\u6cd5\u8ba1\u7b97\u4e24\u4e2a\u86cb\u767d\u8d28\u4e4b\u95f4\u7684\u62d3\u6251\u76f8\u4f3c\u5ea6\uff0c\u4ece\u800c\u8bc4\u4f30\u5b83\u4eec\u53d1\u751f\u76f8\u4e92\u4f5c\u7528\u7684\u53ef\u80fd\u6027\u3002\u5e38\u89c1\u7684\u80fd\u591f\u88ab\u7528\u4e8e\u9884\u6d4b\u76f8\u4e92\u4f5c\u7528\u7684\u7f51\u7edc\u7ed3\u6784\u4fe1\u606f\u5305\u62ec\u5171\u540c\u90bb\u5c45\u3001\u7f51\u7edc\u8def\u5f84\u3001\u5168\u5c40\u7f51\u7edc\u7ed3\u6784\u548c\u51e0\u4f55\u5d4c\u5165\u56db\u79cd\u3002\u8fd9\u56db\u7c7b\u65b9\u6cd5\u80fd\u591f\u4ece\u5c40\u90e8\u548c\u5168\u5c40\u7684\u89d2\u5ea6\u8861\u91cf\u86cb\u767d\u8d28\u5bf9\u62d3\u6251\u76f8\u4f3c\u6027\uff0c\u4ee5\u83b7\u53d6\u66f4\u9ad8\u7684\u9884\u6d4b\u6027\u80fd\u3002<\/span><\/p>\n<\/section>\n

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\u57fa\u4e8e\u5e8f\u5217\u7684\u6a21\u578b<\/span><\/strong><\/p>\n


<\/span><\/p>\n

\u57fa\u4e8e\u6b64\u4fe1\u606f\u7684\u9884\u6d4b\u6a21\u578b\u4e3b\u8981\u901a\u8fc7\u86cb\u767d\u8d28\u5e8f\u5217\u63d0\u53d6\u67d0\u4e9b\u80fd\u591f\u4e3a\u9884\u6d4b\u4efb\u52a1\u63d0\u4f9b\u652f\u6301\u7684\u4fe1\u606f\uff0c\u4f8b\u5982\u6c28\u57fa\u9178\u7684\u758f\u6c34\u6027\u3001\u4eb2\u6c34\u6027\u7b49\uff0c\u7136\u540e\u5229\u7528\u8fd9\u4e9b\u4fe1\u606f\u4e3a\u6bcf\u4e2a\u86cb\u767d\u8d28\u751f\u6210\u552f\u4e00\u7279\u5b9a\u7684\u7279\u5f81\u5411\u91cf\uff0c\u6700\u540e\u628a\u63d0\u53d6\u51fa\u7684\u86cb\u767d\u8d28\u5411\u91cf\u8f93\u5165\u5230\u7ecf\u5178\u7684\u5206\u7c7b\u5668\u4e2d\uff0c\u5982\u652f\u6301\u5411\u91cf\u673a<\/span>\uff08Support Vector Machine\uff0cSVM\uff09<\/span>\u548c\u968f\u673a\u68ee\u6797<\/span>\uff08Random Forests\uff0cRF\uff09<\/span>\uff0c\u5bf9\u86cb\u767d\u8d28\u5bf9\u8fdb\u884c\u4e8c\u5206\u7c7b\u5904\u7406\uff0c\u7531\u6b64\u83b7\u53d6\u9884\u6d4b\u7ed3\u679c\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u7c7b\u6a21\u578b\u80fd\u591f\u57fa\u4e8e\u5e8f\u5217\u4ece\u591a\u79cd\u89d2\u5ea6\u9884\u6d4b\u76f8\u4e92\u4f5c\u7528\uff0c\u5982\uff1a\u5e8f\u5217\u76f8\u4f3c\u6027\u548c\u5171\u540c\u8fdb\u5316\u4fe1\u606f\uff0c\u5e76\u901a\u8fc7\u4e0d\u540c\u7684\u65b9\u6cd5\u4e30\u5bcc\u9884\u6d4b\u4fe1\u606f\uff0c\u66f4\u51c6\u786e\u7684\u8bc6\u522b\u6709\u7528\u7684\u86cb\u767d\u8d28\u5e8f\u5217\uff0c\u8fdb\u4e00\u6b65\u63d0\u5347\u6a21\u578b\u7684\u9884\u6d4b\u6027\u80fd\u3002<\/span><\/p>\n<\/section>\n

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\u57fa\u4e8e\u7ed3\u6784\u7684\u6a21\u578b<\/span><\/strong><\/span><\/p>\n


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\u9664\u4e86\u5e8f\u5217\u5916\uff0c\u86cb\u767d\u8d28\u8fd8\u6709\u4e8c\u7ea7\u7ed3\u6784\u3001\u4e09\u7ea7\u7ed3\u6784\u548c\u56db\u7ea7\u7ed3\u6784\uff0c\u8fd9\u4e09\u4e2a\u7ed3\u6784\u90fd\u662f\u86cb\u767d\u8d28\u5728\u4e00\u7ea7\u7ed3\u6784\u7684\u57fa\u7840\u4e0a\u5f62\u6210\u7684\u66f4\u9ad8\u7ef4\u5ea6\u4e5f\u66f4\u590d\u6742\u7684\u7a7a\u95f4\u7ed3\u6784\u3002\u7531\u4e8e\u76ee\u524d\u5bf9\u8fd9\u4e9b\u9ad8\u7ea7\u7ed3\u6784\u7684\u8ba4\u77e5\u8fdc\u4e0d\u5982\u86cb\u767d\u8d28\u5e8f\u5217\u90a3\u4e48\u591a\uff0c\u6240\u4ee5\uff0c\u57fa\u4e8e\u6b64\u7c7b\u4fe1\u606f\u9884\u6d4b\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7684\u6a21\u578b\u6570\u91cf\u4e5f\u8981\u5927\u5e45\u5ea6\u5c0f\u4e8e\u57fa\u4e8e\u5e8f\u5217\u7684\u6a21\u578b\u3002\u76ee\u524d\uff0c\u86cb\u767d\u8d28\u7684\u4e09\u7ea7\u7ed3\u6784\u662f\u6700\u5e38\u89c1\u7684\u88ab\u7528\u4e8e\u9884\u6d4b\u76f8\u4e92\u4f5c\u7528\u7684\u9ad8\u7ea7\u7ed3\u6784\u4fe1\u606f\uff0c\u57fa\u4e8e\u8be5\u4fe1\u606f\u8fdb\u884c\u9884\u6d4b\u7684\u6a21\u578b\u662f\u6839\u636e\u4ee5\u4e0b\u5047\u8bf4\u5de5\u4f5c\u7684\uff1a\u5982\u679c\u4e24\u4e2a\u86cb\u767d\u8d28\u7684\u76f8\u4e92\u4f5c\u7528\u533a\u57df\u80fd\u591f\u5b8c\u7f8e\u5d4c\u5408\uff0c\u90a3\u4e48\u5b83\u4eec\u4e4b\u95f4\u5f88\u53ef\u80fd\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u57fa\u4e8e\u57fa\u56e0\u7ec4\u7684\u6a21\u578b<\/span><\/strong><\/span><\/p>\n


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\u968f\u7740\u591a\u79cd\u751f\u7269\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u5de5\u4f5c\u7684\u5b8c\u6210\uff0c\u5f88\u591a\u73b0\u8c61\u5982\uff1a\u57fa\u56e0\u878d\u5408\u3001\u57fa\u56e0\u987a\u5e8f\u548c\u7cfb\u7edf\u53d1\u80b2\u56fe\u8c31\u7b49\u53ef\u4ee5\u88ab\u66f4\u597d\u5730\u89c2\u5bdf\u5230\uff0c\u5176\u4e2d\uff0c\u57fa\u4e8e\u57fa\u56e0\u878d\u5408\u7684\u9884\u6d4b\u6a21\u578b\u8ba4\u4e3a\u80fd\u591f\u5728\u53e6\u4e00\u4e2a\u7ec4\u7ec7\u4e2d\u5f7c\u6b64\u878d\u5408\u7684\u4e24\u4e2a\u86cb\u767d\u8d28\uff0c\u66f4\u6709\u53ef\u80fd\u5f7c\u6b64\u53d1\u751f\u76f8\u4e92\u4f5c\u7528\uff1b\u57fa\u4e8e\u57fa\u56e0\u987a\u5e8f\u7684\u6a21\u578b\u8ba4\u4e3a\u57fa\u56e0\u4e4b\u95f4\u7684\u987a\u5e8f\u8868\u660e\u4e86\u5176\u5728\u529f\u80fd\u4e0a\u7684\u76f8\u5173\u6027\uff0c\u800c\u529f\u80fd\u76f8\u5173\u7684\u86cb\u767d\u8d28\u5bf9\u66f4\u53ef\u80fd\u53d1\u751f\u76f8\u4e92\u4f5c\u7528\uff1b\u7cfb\u7edf\u53d1\u80b2\u56fe\u8c31\u901a\u5e38\u5b58\u5728\u4e8e\u7cfb\u7edf\u53d1\u80b2\u6811\u4e2d\uff0c\u57fa\u4e8e\u8be5\u4fe1\u606f\u7684\u6a21\u578b\u8ba4\u4e3a\u86cb\u767d\u8d28\u7cfb\u7edf\u53d1\u80b2\u56fe\u8c31\u7684\u76f8\u4f3c\u6027\u8868\u660e\u4e86\u5176\u5728\u529f\u80fd\u4e0a\u7684\u76f8\u5173\u6027\uff0c\u56e0\u6b64\u5177\u6709\u76f8\u4f3c\u53d1\u80b2\u56fe\u8c31\u7684\u86cb\u767d\u8d28\u66f4\u53ef\u80fd\u53d1\u751f\u76f8\u4e92\u4f5c\u7528\u3002\u867d\u7136\u57fa\u4e8e\u57fa\u56e0\u7ec4\u7684\u6a21\u578b\u5386\u53f2\u60a0\u4e45\u4e14\u5177\u6709\u8f83\u597d\u7684\u6027\u80fd\uff0c\u4f46\u662f\u5bf9\u4e8e\u90a3\u4e9b\u6ca1\u6709\u53d1\u73b0\u57fa\u56e0\u878d\u5408\u4e8b\u4ef6\uff0c\u57fa\u56e0\u987a\u5e8f\u65e0\u6cd5\u83b7\u53d6\uff0c\u4ee5\u53ca\u4e0d\u80fd\u5f88\u597d\u7684\u6620\u5c04\u5176\u7cfb\u7edf\u53d1\u80b2\u56fe\u8c31\u7684\u86cb\u767d\u8d28\u5bf9\uff0c\u5b83\u4eec\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u65e0\u6cd5\u5229\u7528\u6b64\u7c7b\u6a21\u578b\u8fdb\u884c\u9884\u6d4b\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u57fa\u56e0\u672c\u4f53\u8bba\u662f\u7531\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u7684\u7528\u4e8e\u63cf\u8ff0\u57fa\u56e0\u53ca\u5176\u4ea7\u7269\u7279\u6027\u7684\u672f\u8bed\uff0c\u800c\u86cb\u767d\u8d28\u5c31\u662f\u540e\u8005\u7684\u4ee3\u8868\u7269\u8d28\u3002\u8be5\u672f\u8bed\u80fd\u591f\u4ece\u7ec6\u80de\u7ec4\u5206\u3001\u5206\u5b50\u529f\u80fd\u548c\u751f\u7269\u5b66\u8fc7\u7a0b\u4e09\u4e2a\u89d2\u5ea6\u63cf\u8ff0\u86cb\u767d\u8d28\u3002\u7531\u4e8e\u5177\u6709\u76f8\u4f3c\u529f\u80fd\u7684\u4e24\u4e2a\u86cb\u767d\u8d28\u66f4\u53ef\u80fd\u901a\u8fc7\u5f7c\u6b64\u53d1\u751f\u76f8\u4e92\u4f5c\u7528\uff0c\u6765\u627f\u62c5\u7ec6\u80de\u4f53\u5185\u7684\u540c\u4e00\u4e2a\u751f\u7406\u529f\u80fd\uff0c\u800c\u57fa\u56e0\u672c\u4f53\u8bba\u53c8\u63d0\u4f9b\u4e86\u83b7\u53d6\u86cb\u767d\u8d28\u529f\u80fd\u4fe1\u606f\u7684\u76f8\u5e94\u9014\u5f84\uff0c\u6240\u4ee5\uff0c\u53ef\u4ee5\u901a\u8fc7\u67d0\u4e9b\u65b9\u6cd5\u8ba1\u7b97\u86cb\u767d\u8d28\u5bf9\u7684\u57fa\u56e0\u672c\u4f53\u8bba\u76f8\u4f3c\u6027\uff0c\u4ece\u800c\u8bc4\u4f30\u5b83\u4eec\u7684\u529f\u80fd\u76f8\u4f3c\u6027\uff0c\u8fdb\u800c\u9884\u6d4b\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u3002\u867d\u7136\u6709\u7814\u7a76\u8868\u660e\u57fa\u4e8e\u57fa\u56e0\u672c\u4f53\u8bba\u7684\u7279\u5f81\u6bd4\u57fa\u4e8e\u5e8f\u5217\u7684\u9891\u8c31\u8ba1\u6570\u7279\u5f81\u5177\u6709\u66f4\u597d\u7684\u6027\u80fd\u3002\u4f46\u662f\uff0c\u6b64\u7c7b\u6a21\u578b\u591a\u6570\u6ca1\u6709\u8003\u8651\u7ec6\u80de\u7ec4\u5206\u4fe1\u606f\u4ee5\u53ca\u57fa\u56e0\u672c\u4f53\u8bba\u7c7b\u522b\u5c42\u6b21\u7ed3\u6784\u4e2d\u4e0d\u76f8\u7b49\u7684\u6df1\u5ea6\u5bf9\u4e8e\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u9884\u6d4b\u5e26\u6765\u7684\u5f71\u54cd\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u6a21\u578b<\/span><\/strong><\/span><\/p>\n


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\u6df1\u5ea6\u5b66\u4e60\u662f\u8fd1\u5e74\u6765\u5174\u8d77\u7684\u4e00\u9879\u65b0\u6280\u672f\uff0c\u5f53\u88ab\u5e94\u7528\u4e8e\u9884\u6d4b\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u65f6\uff0c\u6df1\u5ea6\u5b66\u4e60\u6280\u672f\u5f3a\u5927\u7684\u5b66\u4e60\u80fd\u529b\u80fd\u591f\u66f4\u51c6\u786e\u3001\u66f4\u81ea\u52a8\u5316\u5730\u5b66\u4e60\u86cb\u767d\u8d28\u7684\u7279\u5f81\uff0c\u4ece\u800c\u751f\u6210\u66f4\u7cbe\u786e\u7684\u7279\u5f81\u5411\u91cf\uff0c\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u6a21\u578b\u4e0d\u4ec5\u80fd\u591f\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u63d0\u5347\u5bf9\u4e8e\u76f8\u4e92\u4f5c\u7528\u7684\u9884\u6d4b\u80fd\u529b\uff0c\u800c\u4e14\u53ef\u4ee5\u8fdb\u4e00\u6b65\u51cf\u5c11\u4eba\u529b\u7684\u6d88\u8017\u3002\u8be5\u7c7b\u6a21\u578b\u548c\u57fa\u4e8e\u5e8f\u5217\u7684\u6a21\u578b\u539f\u7406\u7c7b\u4f3c\uff0c\u90fd\u662f\u4ece\u86cb\u767d\u8d28\u4e2d\u63d0\u53d6\u67d0\u4e9b\u548c\u76f8\u4e92\u4f5c\u7528\u76f8\u5173\u7684\u4fe1\u606f\u4f5c\u4e3a\u7279\u5f81\u5411\u91cf\uff0c\u7136\u540e\u5229\u7528\u8fd9\u4e9b\u7279\u5f81\u5411\u91cf\u7ed3\u5408\u73b0\u6709\u7684\u5206\u7c7b\u5668\u6a21\u578b\u8bc4\u4f30\u4e24\u4e2a\u86cb\u767d\u8d28\u4e4b\u95f4\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\u7684\u6982\u7387\u3002\u4e0e\u4e0a\u8ff0\u51e0\u79cd\u7c7b\u578b\u7684\u9884\u6d4b\u6a21\u578b\u76f8\u6bd4\uff0c\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u6a21\u578b\u80fd\u591f\u53d1\u6325\u6df1\u5ea6\u5b66\u4e60\u6280\u672f\u7684\u4f18\u52bf\uff0c\u6316\u6398\u6f5c\u5728\u7684\u6709\u4ef7\u503c\u7684\u86cb\u767d\u8d28\u7279\u5f81\u4fe1\u606f\uff0c\u4f7f\u5f97\u6a21\u578b\u7684\u9884\u6d4b\u6027\u80fd\u66f4\u597d\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5927\u89c4\u6a21\u9884\u6d4b\u6a21\u578b<\/span><\/strong><\/span><\/p>\n


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\u76ee\u524d\uff0c\u5df2\u7ecf\u9274\u5b9a\u51fa\u7684\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7684\u6570\u636e\u8fd8\u4e0d\u5230\u6574\u4e2a\u76f8\u4e92\u4f5c\u7528\u7ec4\u768420\uff05\u3002\u968f\u7740\u9ad8\u901a\u91cf\u6280\u672f\u7684\u53d1\u5c55\uff0c\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u6570\u636e\u7684\u5927\u5c0f\u548c\u590d\u6742\u6027\u4e5f\u5927\u5927\u589e\u52a0\u3002\u5927\u89c4\u6a21\u9884\u6d4b\u6a21\u578b\u901a\u5e38\u91c7\u7528\u5206\u5e03\u5f0f\u7684\u65b9\u6cd5\uff0c\u5e76\u884c\u9884\u6d4b\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff0c\u4ee5\u63d0\u9ad8\u6a21\u578b\u7684\u6548\u7387\uff0c\u4f46\u7531\u4e8e\u5404\u7c7b\u6a21\u578b\u6240\u91c7\u7528\u6280\u672f\u7684\u5c40\u9650\u6027\uff0c\u5e76\u4e0d\u662f\u6240\u6709\u5927\u89c4\u6a21\u9884\u6d4b\u6a21\u578b\u90fd\u80fd\u4fdd\u8bc1\u9884\u6d4b\u6027\u80fd\u4f18\u79c0\u4e14\u9884\u6d4b\u6548\u7387\u9ad8\u6548\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5b9e\u9a8c\u65b9\u6848<\/span><\/strong><\/p>\n


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\u4e3a\u4e86\u5b9e\u73b0\u51c6\u786e\u9884\u6d4b\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff0c\u73b0\u6709\u7684\u8ba1\u7b97\u6a21\u578b\u901a\u5e38\u9075\u5faa\u6709\u76d1\u7763\u7684\u5b66\u4e60\u6846\u67b6\uff0c\u51c6\u5907\u76f8\u4e92\u4f5c\u7528\u548c\u975e\u76f8\u4e92\u4f5c\u7528\u7684\u86cb\u767d\u8d28\u5bf9\u6570\u636e\u3002\u5176\u4e2d\uff0c\u76f8\u4e92\u4f5c\u7528\u6570\u636e\u662f\u9633\u6027\u6837\u54c1\uff0c\u975e\u76f8\u4e92\u4f5c\u7528\u662f\u9634\u6027\u6837\u54c1\u3002\u524d\u8005\u53ef\u4ee5\u4ece\u6570\u636e\u5e93\u4e2d\u660e\u786e\u63d0\u53d6\uff0c\u540e\u8005\u53ef\u5229\u7528\u968f\u673a\u751f\u6210\u7b56\u7565\u3001\u7ec6\u80de\u5b9a\u4f4d\u7b56\u7565\u548cNegatome 2.0\u83b7\u53d6\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e00\u65e6\u83b7\u5f97\u4e86\u5b9e\u9a8c\u6570\u636e\uff0c\u4e0b\u4e00\u6b65\u5c31\u662f\u9009\u62e9\u5408\u9002\u7684\u65b9\u6848\u8fdb\u884c\u6027\u80fd\u8bc4\u4f30\u3002\u901a\u5e38\uff0c\u5b9e\u9a8c\u6570\u636e\u53ef\u5206\u4e3a\u8bad\u7ec3\u96c6\u548c\u6d4b\u8bd5\u96c6\uff0c\u524d\u8005\u7528\u4e8e\u8bad\u7ec3\u6a21\u578b\uff0c\u540e\u8005\u7528\u4e8e\u9a8c\u8bc1\u6a21\u578b\u6027\u80fd\u3002\u5e38\u88ab\u7528\u6765\u5212\u5206\u8bad\u7ec3\u96c6\u548c\u6d4b\u8bd5\u96c6\u7684\u65b9\u6848\u5305\u62ec\u4e09\u79cd\uff1a\u968f\u673a\u5b50\u62bd\u6837\u9a8c\u8bc1\u3001K\u6298\u4ea4\u53c9\u9a8c\u8bc1\u3001\u7559\u4e00\u6cd5\u4ea4\u53c9\u9a8c\u8bc1\u3002<\/span><\/p>\n<\/section>\n

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\u6027\u80fd\u8bc4\u4f30<\/span><\/strong><\/span><\/p>\n


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\u8981\u5b9a\u91cf\u8bc4\u4f30\u8ba1\u7b97\u6a21\u578b\u9884\u6d4b\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7684\u6027\u80fd\uff0c\u53ef\u4ee5\u4f7f\u7528\u56db\u79cd\u8bc4\u4f30\u6307\u6807\uff1aMatthew\u76f8\u5173\u7cfb\u6570<\/span>\uff08MCC\uff09<\/span>\u3001F1\u5f97\u5206\u3001AUC\u548cPR-AUC\u3002\u5176\u4e2d\uff0cMCC\u662f\u4e00\u79cd\u5e73\u8861\u5ea6\u91cf\u6307\u6807\uff0c\u4e0d\u4ec5\u53ef\u4ee5\u6307\u793a\u9884\u6d4b\u7ed3\u679c\u4e0e\u771f\u5b9e\u7ed3\u679c\u4e4b\u95f4\u7684\u76f8\u5173\u7cfb\u6570\uff0c\u8fd8\u53ef\u4ee5\u5904\u7406\u6570\u636e\u96c6\u4e0d\u5e73\u8861\u7684\u60c5\u51b5\uff1bF1\u5f97\u5206\u662f\u4e3a\u4e86\u5e73\u8861\u67e5\u5168\u7387\u548c\u67e5\u51c6\u7387\u800c\u88ab\u63d0\u51fa\u7684\uff0c\u662f\u5b83\u4eec\u7684\u8c03\u548c\u5e73\u5747\u6570\uff1bAUC\u662fROC\u66f2\u7ebf\u4e0e\u5750\u6807\u8f74\u6240\u56f4\u9762\u79ef\u7684\u503c\uff0c\u800cROC\u66f2\u7ebf\u662f\u4ee5FPR\u4e3a\u6a2a\u8f74\uff0cTPR\u4e3a\u7eb5\u8f74\u6240\u505a\uff1bPR-AUC\u662f PR\u66f2\u7ebf\u4e0e\u5750\u6807\u8f74\u6240\u56f4\u9762\u79ef\u7684\u503c\uff0c\u800cPR\u66f2\u7ebf\u662f\u4ee5\u67e5\u5168\u7387\u4e3a\u6a2a\u8f74\uff0c\u67e5\u51c6\u7387\u4e3a\u7eb5\u8f74\u6240\u505a\u3002<\/span><\/p>\n


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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n

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\u5728\u7ebf\u9884\u6d4b\u5de5\u5177\u5305\u62ec\uff1aBIPS\u3001OpenPPI_predictor\u3001PrePPI\u3001PIP\u3001PSOPIA\u3001HIPPIE\u548cMEGADOCK-Web\u3002\u5728\u8fd9\u4e9b\u5de5\u5177\u4e2d\uff0c\u5b83\u4eec\u80fd\u591f\u901a\u8fc7\u86cb\u767d\u8d28\u76f8\u5173\u6570\u636e\u5e93\u4ee5\u53ca\u751f\u7269\u4fe1\u606f\u5bf9\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u8fdb\u884c\u9884\u6d4b\u3002\u9664\u4e86OpenPPI_predictor\u9700\u8981\u4e0b\u8f7d\u5916\uff0c\u5176\u4ed6\u5de5\u5177\u90fd\u76f4\u63a5\u63d0\u4f9b\u4e86Web\u9875\u9762\u3002<\/span><\/p>\n


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\u672a\u6765\u7684\u6311\u6218\u548c\u5de5\u4f5c\u53ef\u4ee5\u4ece\u4ee5\u4e0b\u4e94\u65b9\u9762\u5c55\u5f00\uff1a<\/span><\/p>\n


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\uff081\uff09\u76ee\u524d\u7edd\u5927\u591a\u6570\u9884\u6d4b\u6a21\u578b\u90fd\u662f\u9075\u5faa\u76d1\u7763\u5b66\u4e60\u7684\u8303\u5f0f\u63d0\u51fa\u7684\uff0c\u8bad\u7ec3\u96c6\u6570\u636e\u7684\u8d28\u91cf\u662f\u51b3\u5b9a\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u9884\u6d4b\u51c6\u786e\u6027\u7684\u5173\u952e\u95ee\u9898\u3002\u56e0\u6b64\u6211\u4eec\u6709\u5fc5\u8981\u5728\u5b9e\u9a8c\u8fc7\u7a0b\u4e2d\u5bf9\u76f8\u4e92\u4f5c\u7528\u6570\u636e\u8fdb\u884c\u9884\u5904\u7406\uff0c\u4ee5\u786e\u4fdd\u6570\u636e\u7684\u8d28\u91cf\uff0c\u4ece\u800c\u66f4\u52a0\u51c6\u786e\u5730\u5bf9\u9884\u6d4b\u6a21\u578b\u6027\u80fd\u8fdb\u884c\u8bc4\u4f30\u3002\u540c\u65f6\uff0c\u9664\u4e86\u76f8\u4e92\u4f5c\u7528\u6570\u636e\u5916\uff0c\u6211\u4eec\u8fd8\u53ef\u4ee5\u8003\u8651\u86cb\u767d\u8d28\u5176\u4ed6\u7684\u751f\u7269\u5b66\u4fe1\u606f\uff0c\u6765\u62b5\u6d88\u5bf9\u76f8\u4e92\u4f5c\u7528\u6570\u636e\u9ad8\u5ea6\u4f9d\u8d56\u5bfc\u81f4\u7684\u8d1f\u9762\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u5982\u4f55\u6709\u6548\u5730\u6574\u5408\u591a\u79cd\u751f\u7269\u4fe1\u606f\u8d44\u6e90\u4ee5\u8fdb\u884c\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u9884\u6d4b\u4ecd\u7136\u662f\u672a\u6765\u9700\u8981\u89e3\u51b3\u7684\u4e3b\u8981\u6311\u6218\u4e4b\u4e00\u3002
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\uff082\uff09\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u5728\u4e0d\u540c\u7684\u7ec6\u80de\u4e2d\u548c\u540c\u4e00\u4e2a\u7ec6\u80de\u7684\u4e0d\u540c\u5468\u671f\u4e2d\u90fd\u662f\u4e0d\u540c\u7684\uff0c\u672a\u6765\u7814\u7a76\u5e94\u8be5\u96c6\u4e2d\u5728\u9884\u6d4b\u52a8\u6001\u76f8\u4e92\u4f5c\u7528\u4e0a\u9762\u3002\u968f\u7740\u70ed\u90bb\u8fd1\u5171\u805a\u6280\u672f<\/span>\uff08Thermal Proximity Coaggregation\uff0cTPCA\uff09<\/span>\u548c\u4e0b\u4e00\u4ee3\u6d4b\u5e8f\u6280\u672f\u5982RNA-seq\u7684\u53d1\u5c55\uff0c\u6211\u4eec\u53ef\u4ee5\u5229\u7528TPCA\u7279\u5f81\u548cRNA-seq\u7684\u65f6\u95f4\u5e8f\u5217\u6570\u636e\u8bbe\u8ba1\u65b0\u7684\u52a8\u6001\u9884\u6d4b\u6a21\u578b\u3002<\/span><\/p>\n


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\uff083\uff09\u591a\u6570\u6a21\u578b\u901a\u5e38\u4f7f\u7528\u9175\u6bcd\u6216\u4eba\u7c7b\u6570\u636e\u96c6\u8bc4\u4f30\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u9884\u6d4b\u6a21\u578b\u7684\u6027\u80fd\uff0c\u800c\u5b58\u5728\u5171\u540c\u8fdb\u5316\u7684\u8bc1\u636e\u8868\u660e\uff0c\u76f8\u4e92\u4f5c\u7528\u7684\u67d0\u4e9b\u8fdb\u5316\u6a21\u5f0f\u5728\u4e0d\u540c\u7269\u79cd\u4e4b\u95f4\u662f\u4fdd\u5b88\u7684\u3002\u56e0\u6b64\uff0c\u672a\u6765\u7684\u5de5\u4f5c\u53ef\u96c6\u4e2d\u5728\u6839\u636e\u8fdb\u5316\u6a21\u5f0f\u9884\u6d4b\u4e0d\u540c\u7269\u79cd\u4e2d\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/span><\/p>\n


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\uff085\uff09\u5728\u57fa\u4e8e\u7f51\u7edc\u9884\u6d4b\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u65f6\uff0c\u5f88\u5c11\u6709\u6a21\u578b\u4f1a\u8003\u8651\u5c40\u90e8\u7f51\u7edc\u7ed3\u6784\u548c\u5168\u5c40\u7f51\u7edc\u7ed3\u6784\u7684\u4e92\u8865\u6027\u3002\u6b64\u5916\uff0c\u5982\u4f55\u5c06\u86cb\u767d\u8d28\u7684\u751f\u7269\u5b66\u4fe1\u606f\u6574\u5408\u5230\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u4e2d\u4ecd\u7136\u662f\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u9884\u6d4b\u9700\u8981\u89e3\u51b3\u7684\u96be\u9898\u3002\u968f\u7740\u5c5e\u6027\u56fe\u805a\u7c7b\u7b97\u6cd5\u7684\u5174\u8d77\uff0c\u5c06\u5c40\u90e8\u548c\u5168\u5c40\u7f51\u7edc\u7ed3\u6784\u4e0e\u5c5e\u6027\u56fe\u805a\u7c7b\u7b97\u6cd5\u7ed3\u5408\u53ef\u80fd\u662f\u672a\u6765\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u9884\u6d4b\u7684\u91cd\u70b9\u3002<\/span><\/p>\n<\/section>\n


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\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/strong><\/span><\/p>\n

Lun Hu, Xiaojuan Wang, Yu-An Huang, Pengwei Hu, Zhu-Hong You, A survey on computational models for predicting protein\u2013protein interactions, Briefings in Bioinformatics, 2021;, bbab036, <\/span><\/p>\n

https:\/\/doi.org\/10.1093\/bib\/bbab036<\/span><\/p>\n


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\u96c6\u667a\u6591\u56fe\u9876\u520a\u8bba\u6587\u901f\u9012\u680f\u76ee\u4e0a\u7ebf\u4ee5\u6765\uff0c\u6301\u7eed\u6536\u5f55\u6765\u81eaNature\u3001Science<\/span>\u7b49\u9876\u520a\u7684\u6700\u65b0\u8bba\u6587\uff0c\u8ffd\u8e2a\u590d\u6742\u7cfb\u7edf\u3001\u7f51\u7edc\u79d1\u5b66\u3001\u8ba1\u7b97\u793e\u4f1a\u79d1\u5b66\u7b49\u9886\u57df\u7684\u524d\u6cbf\u8fdb\u5c55\u3002\u73b0\u5728\u6b63\u5f0f\u63a8\u51fa\u8ba2\u9605\u529f\u80fd\uff0c\u6bcf\u5468\u901a\u8fc7\u5fae\u4fe1\u670d\u52a1\u53f7\u300c\u96c6\u667a\u6591\u56fe\u300d\u63a8\u9001\u8bba\u6587\u4fe1\u606f\u3002\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\u5373\u53ef\u4e00\u952e\u8ba2\u9605\uff1a<\/span>
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