{"id":26218,"date":"2021-05-13T21:25:40","date_gmt":"2021-05-13T13:25:40","guid":{"rendered":"https:\/\/swarma.org\/?p=26218"},"modified":"2021-05-13T21:25:40","modified_gmt":"2021-05-13T13:25:40","slug":"nature%e9%80%9a%e8%ae%af%ef%bc%9a%e9%80%9a%e8%bf%87%e6%b7%b1%e5%ba%a6%e7%94%9f%e6%88%90%e7%bd%91%e7%bb%9c%e5%af%b9%e5%8d%95%e7%bb%86%e8%83%9e%e8%bd%ac%e5%bd%95%e6%95%b0%e6%8d%ae%e8%bf%9b%e8%a1%8c","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=26218","title":{"rendered":"Nature\u901a\u8baf\uff1a\u901a\u8fc7\u6df1\u5ea6\u751f\u6210\u7f51\u7edc\u5bf9\u5355\u7ec6\u80de\u8f6c\u5f55\u6570\u636e\u8fdb\u884c\u53cc\u66f2\u5d4c\u5165"},"content":{"rendered":"
\n
\n
\n
\n

<\/p>\n<\/section>\n

\n
\n
\n
\n
\n
\n

<\/section>\n<\/section>\n
\n
\n

\u5bfc\u8bed<\/strong><\/p>\n<\/section>\n<\/section>\n

\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

<\/strong>\u53cc\u66f2\u7a7a\u95f4\u5d4c\u5165\u662f\u7814\u7a76\u590d\u6742\u7f51\u7edc\u7684\u65b0\u5174\u65b9\u6cd5\u30025\u67085\u65e5\u4e00\u7bc7\u53d1\u8868\u5728 Nature Communications <\/em>\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d\uff0c\u7814\u7a76\u8005\u901a\u8fc7\u7ed3\u5408\u5bf9\u6297\u751f\u6210\u7f51\u7edc\u5bf9\u5355\u7ec6\u80de\u8f6c\u5f55\u6570\u636e\u8fdb\u884c\u964d\u7ef4\uff0c\u4ece\u800c\u627e\u5230\u7279\u5f81\u5411\u91cf\u3002\u8be5\u6587\u7684\u65b9\u6cd5\u5bf9\u5927\u89c4\u6a21\u5355\u7ec6\u80de\u548c\u7a7a\u95f4\u7ec4\u5b66\u7814\u7a76\u6709\u4e00\u5b9a\u542f\u53d1\u3002<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
\n

\u90ed\u745e\u4e1c<\/span> | \u4f5c\u8005<\/strong><\/span><\/strong><\/p>\n<\/section>\n

\n

\u8d75\u96e8\u4ead<\/span> | \u5ba1\u6821<\/strong><\/span><\/p>\n

\u9093\u4e00\u96ea<\/span> | \u7f16\u8f91<\/strong><\/span><\/p>\n<\/section>\n


<\/p>\n


<\/span><\/p>\n

<\/section>\n
\n
\n
\n

\u8bba\u6587\u9898\u76ee\uff1a<\/span><\/p>\n

Deep generative model embedding of single-cell RNA-Seq profiles on hyperspheres and hyperbolic spaces<\/span><\/h1>\n

\u8bba\u6587\u5730\u5740\uff1a<\/span><\/p>\n

https:\/\/www.nature.com\/articles\/s41467-021-22851-4<\/span><\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n


<\/p>\n

 <\/span><\/section>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

1. \u5355\u7ec6\u80de\u8f6c\u5f55\u6570\u636e\u964d\u7ef4\u5b58\u5728\u7684\u95ee\u9898<\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u901a\u8fc7\u6d4b\u91cf\u4e0d\u540c\u7c7b\u578b\u7684\u5355\u4e2a\u7ec6\u80de\u4e2d\uff0c\u5404\u4e2a\u57fa\u56e0\u5bf9\u5e94 RNA \u7684\u8868\u8fbe\u91cf\uff0c\u5355\u7ec6\u80de\u8f6c\u5f55\u672c\u6d4b\u5e8f\u53ef\u4ee5\u8003\u5bdf\u4e0d\u540c\u7ec6\u80de\u7684\u5f02\u8d28\u6027\uff0c\u8fd9\u5bf9\u751f\u7269\u7cfb\u7edf\u7684\u7814\u7a76\u81f3\u5173\u91cd\u8981\u3002\u7531\u4e8e\u5355\u7ec6\u80de\u6d4b\u5e8f\u4ea7\u751f\u7684\u6570\u636e\u5177\u6709\u867d\u7136\u7ef4\u5ea6\u9ad8\uff0c\u4f46\u7531\u4e8e\u5f88\u591a\u5904\u5728\u540c\u4e00\u901a\u8def\u4e0a\u7684\u57fa\u56e0\u662f\u5171\u8868\u8fbe\u7684\u7279\u70b9\uff0c\u5176\u4e8b\u5b9e\u7684\u7ef4\u5ea6\u5f88\u4f4e\u3002\u540c\u65f6\uff0c\u7531\u4e8e\u7ec6\u80de\u7c7b\u578b\u7684\u4e0d\u540c\u80fd\u591f\u89e3\u91ca\u5927\u90e8\u5206\u8868\u8fbe\u91cf\u5dee\u5f02\uff0c\u56e0\u6b64\u964d\u7ef4\u5df2\u6210\u4e3a\u5355\u7ec6\u80de\u8f6c\u5f55\u672c\u5206\u6790\u4e2d\u7684\u6838\u5fc3\u6b65\u9aa4\u3002<\/span><\/p>\n

      <\/span>\u56fe1. \u4f7f\u7528 tSNE \u548c UMAP \u4e24\u8005\u5e38\u7528\u7684\u805a\u7c7b\u65b9\u6cd5\uff0c\u5bf9102\u79cd\u4eba\u7c7b\u7ec6\u80de\u7cfb\u8fdb\u884c\u805a\u7c7b\u7684\u7ed3\u679c\uff0c\u5176\u4e2d\u5f88\u591a\u4e0d\u540c\u7c7b\u578b\u7684\u7ec6\u80de\u88ab\u805a\u5728\u4e00\u8d77\uff0c\u4e14\u4e0d\u540c\u7c7b\u578b\u7684\u7ec6\u80de\u95f4\u8ddd\u79bb\u66f4\u8fd1<\/span><\/span><\/p>\n

<\/span><\/section>\n


<\/p>\n

\u5f53\u524d\u57fa\u4e8e\u62d3\u6251\u7684\u805a\u7c7b\u65b9\u6cd5\u2014\u2014\u4f8b\u5982\u5e38\u7528\u7684 tSNE \u548c UMAP\u3001\u4ee5\u53ca\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u5206\u6790\u7684\u53e6\u4e00\u7c7b\u5e38\u7528\u65b9\u6cd5\uff1a\u53d8\u5206\u81ea\u7f16\u7801\u5668<\/span>\uff08VAEs\uff09<\/span>\u2014\u2014\u90fd\u5047\u8bbe\u5728\u4f4e\u7ef4\u7684\u9690\u7a7a\u95f4\u4e0a\uff0c\u6570\u636e\u7b26\u5408\u591a\u7ef4\u6b63\u6001\u5206\u5e03\u3002\u5f53\u8bad\u7ec3\u65f6\u95f4\u8db3\u591f\u957f\u540e\uff0c\u8fd9\u4f1a\u4f7f\u5f97\u6765\u81ea\u4e0d\u540c\u7c7b\u578b\u7684\u7ec6\u80de\u90fd\u805a\u96c6\u5728\u9690\u7a7a\u95f4\u4e2d\u7684\u9ad8\u65af\u5206\u5e03\u7684\u4e2d\u5fc3\u4f4d\u7f6e\uff0c\u4ece\u800c\u9020\u6210\u4e0d\u540c\u7c7b\u578b\u7684\u7ec6\u80de\u805a\u7c7b\u4e00\u8d77\u3002<\/span><\/p>\n


<\/p>\n

\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\u5206\u6790\u7684\u7b2c\u4e8c\u4e2a\u6311\u6218\uff0c\u6765\u81ea\u5f53\u524d\u7684\u6a21\u578b\uff0c\u90fd\u4f7f\u7528\u4f59\u5f26\u8ddd\u79bb\u6d4b\u91cf\u4e24\u4e2a\u7ec6\u80de\u4e4b\u95f4\u7684\u8868\u8fbe\u91cf\u5dee\u5f02\u3002\u5f53\u9762\u5bf9\u4e0d\u8db3\u4ee5\u5206\u7fa4\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e<\/span>\uff08\u5728\u4e00\u4e2a\u5178\u578b\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\u4e2d\uff0c\u8d85\u8fc790% \u7684\u57fa\u56e0\u6ca1\u6709\u8868\u8fbe\uff09<\/span>\u65f6\uff0c\u7ecf\u8fc7\u6b63\u5219\u5316\u7684\u4f59\u5f26\u8ddd\u79bb\uff0c\u7b49\u4ef7\u4e8e\u6b27\u5f0f\u8ddd\u79bb\u3002\u7136\u800c\u5728\u7a00\u758f\u6570\u636e\u96c6\u4e0a\uff0c\u6b27\u5f0f\u8ddd\u79bb\u65e0\u6cd5\u51c6\u786e\u63cf\u8ff0\u7ec6\u80de\u95f4\u7684\u5dee\u5f02\uff0c\u4ece\u800c\u5bf9\u964d\u7ef4\u5de5\u5177\u4ea7\u751f\u4e86\u626d\u66f2\u3002<\/span><\/p>\n


<\/p>\n

\u5f53\u524d\u7684\u5206\u6790\u65b9\u6cd5\uff0c\u5bf9\u5355\u7ec6\u80de\u8f6c\u5f55\u672c\u7684\u5206\u6790\u9700\u8981\u7ecf\u8fc7\u591a\u4e2a\u72ec\u7acb\u7684\u6b65\u9aa4\uff1a\u4f8b\u5982\u6b63\u5219\u5316\u3001\u6279\u6b21\u6821\u6b63\u3001\u6570\u636e\u964d\u7ef4\u548c\u53ef\u89c6\u5316\uff0c\u6bcf\u4e00\u6b65\u90fd\u6709\u5404\u81ea\u5bf9\u5e94\u7684\u7b97\u6cd5\uff0c\u7f3a\u5c11\u4e00\u4e2a\u7aef\u5bf9\u7aef\u7684\u5206\u6790\u6846\u67b6\u3002\u540c\u65f6\uff0c\u6bcf\u4e00\u6b21\u7684\u6821\u6b63\uff0c\u53ea\u9488\u5bf9\u4e00\u4e2a\u5355\u72ec\u7684\u56e0\u7d20\uff0c\u4f8b\u5982\u4e0d\u540c\u6d4b\u5e8f\u5e73\u53f0\u548c\u6279\u6b21\u3001\u4e0d\u540c\u65f6\u95f4\u68c0\u6d4b\u7b49\u3002\u73b0\u6709\u7684\u6279\u6b21\u6821\u6b63\u65b9\u6cd5\u90fd\u65e0\u6cd5\u5f88\u597d\u5730\u5904\u7406\u8fd9\u4e9b\u7531\u590d\u6742\u7684\u591a\u91cd\u56e0\u7d20\u9020\u6210\u7684\u5f71\u54cd\u3002\u4f46\u662f\u6821\u6b63\u8fd9\u4e9b\u6df7\u6742\u56e0\u7d20\uff0c\u5bf9\u4e8e\u6574\u5408\u4e0d\u540c\u7814\u7a76\u7684\u6570\u636e\u3001\u89e3\u91ca\u5404\u79cd\u56e0\u5b50\u5bf9\u590d\u6742\u7ec4\u7ec7\u4e2d\u7ec6\u80de\u7684\u5f71\u54cd\u4ee5\u53ca\u6700\u7ec8\u6784\u5efa\u5927\u578b\u7684\u7ec6\u80de\u8868\u8fbe\u8c31\u53c2\u8003\u96c6\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002<\/span><\/p>\n


<\/span><\/p>\n

 <\/span><\/section>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

2. \u57fa\u4e8e\u6df1\u5ea6\u751f\u6210\u6a21\u578b\u7684\u5355\u7ec6\u80de\u8868\u8fbe\u91cf\uff0c<\/strong><\/strong><\/p>\n

\u4e3a\u4f55\u9700\u8981\u8fdb\u884c\u53cc\u66f2\u5d4c\u5165
<\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u8be5\u6587\u63d0\u51fa\u7684\u5206\u6790\u6846\u67b6\uff0c\u540d\u4e3a scPhere\uff0c\u662f\u4e00\u4e2a\u7aef\u5bf9\u7aef\u7684\u6a21\u578b\uff1a\u4e0d\u9700\u8981\u5bf9\u57fa\u56e0\u8868\u8fbe\u5206\u5e03\u8fdb\u884c\u6b63\u5219\u5316\u548c\u6279\u6b21\u6821\u6b63\uff0c\u5c31\u53ef\u4ee5\u6355\u6349\u4e0d\u540c\u7ec6\u80de\u95f4\u7684\u56fa\u6709\u5c5e\u6027\u3001\u5904\u7406\u590d\u6742\u7684\u6279\u6b21\u6548\u5e94\u3002\u8be5\u65b9\u6cd5\u901a\u8fc7\u5c06\u8868\u8fbe\u91cf\u77e9\u9635\u5d4c\u5165\u5230\u4f4e\u7ef4\u7684\u53cc\u66f2\u7403\u9762\u800c\u975e\u4f4e\u7ef4\u6b27\u6c0f\u7a7a\u95f4\uff0c\u6765\u51cf\u5c11\u6570\u636e\u5904\u7406\u8fc7\u7a0b\u4e2d\u7684\u626d\u66f2\u3002\u8be5\u65b9\u6cd5\u5047\u8bbe\u5728\u53cc\u66f2\u7a7a\u95f4\u6216\u7403\u5f62\u7a7a\u95f4\u4e2d\uff0c\u4e0d\u540c\u7c7b\u578b\u7684\u7ec6\u80de\u5448\u5747\u5300\u5206\u5e03\uff0c\u56e0\u6b64\u4e0d\u4f1a\u51fa\u73b0\u4e0d\u540c\u7ec6\u80de\u88ab\u8feb\u805a\u96c6\u5728\u4e00\u8d77\u7684\u60c5\u51b5\u3002<\/span><\/p>\n

       <\/span><\/section>\n
\u56fe2. \u4f7f\u7528 scPhere\uff0c\u5bf9102\u79cd\u4eba\u7c7b\u7ec6\u80de\u7cfb\u8fdb\u884c\u805a\u7c7b\u7684\u7ed3\u679c\u53ef\u89c6\u5316\uff0c\u5176\u4e2d\u4e0d\u540c\u7c7b\u578b\u7ec6\u80de\u6ca1\u6709\u805a\u7c7b\u3002\u4e14\u5176\u805a\u7c7b\u7ed3\u679c\uff0c\u4e0e\u901a\u8fc7 KNN \u7b97\u6cd5\u9884\u6d4b\u7ec6\u80de\u7c7b\u578b\u76f8\u6bd4\uff0c\u51c6\u786e\u5ea6\u8fbe\u5230 92.21%\uff0c\u4f18\u4e8e tSNE \u548c UMAP \u768479.22%\u548c 83.12%\u3002<\/span><\/section>\n


<\/p>\n

\u800c\u8fd1\u6765\u7684\u4f17\u591a\u7814\u7a76\uff0c\u4e5f\u8bc1\u660e\u4e86\u5f88\u591a\u590d\u6742\u7f51\u7edc\u5bf9\u5e94\u9690\u7a7a\u95f4\u4e2d\u7684\u8282\u70b9\u8ddd\u79bb\uff0c\u5e94\u8be5\u662f\u53cc\u66f2\u8ddd\u79bb\u3002\u4f8b\u5982\uff1a<\/span><\/p>\n