{"id":26544,"date":"2021-05-28T23:14:31","date_gmt":"2021-05-28T15:14:31","guid":{"rendered":"https:\/\/swarma.org\/?p=26544"},"modified":"2021-05-28T23:14:31","modified_gmt":"2021-05-28T15:14:31","slug":"%e8%9b%8b%e7%99%bd%e8%b4%a8%e7%bb%93%e6%9e%84%e9%a2%84%e6%b5%8b%e7%9a%84%e7%aa%81%e7%a0%b4","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=26544","title":{"rendered":"\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7684\u7a81\u7834"},"content":{"rendered":"<div class='wxsyncmain'>\n<section powered-by=\"xiumi.us\" data-mpa-powered-by=\"yiban.io\">\n<section powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 661px;vertical-align: top;background-color: rgb(246, 246, 246);\">\n<section>\n<p style=\"font-size: 12px;white-space: normal;\"><img loading=\"lazy\" class=\"rich_pages\" data-ratio=\"0.66640625\" data-s=\"300,640\"  data-type=\"png\" data-w=\"1280\" height=\"435\" style=\"font-size: 17px;box-sizing: border-box !important;visibility: visible 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none;border-width: 3px 3px 2px;border-radius: 0px;border-color: rgb(33, 166, 210) rgb(33, 166, 210) rgb(15, 76, 129);\"><br  \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"transform: translate3d(-1px, 0px, 0px);\">\n<section style=\"text-align: justify;color: rgb(33, 166, 210);font-size: 16px;line-height: 1.5;\">\n<p><strong>\u5bfc\u8bed<\/strong><\/p>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"transform: translate3d(-13px, 0px, 0px) rotateX(180deg);\">\n<section style=\"display: inline-block;width: 24px;height: 10px;vertical-align: top;overflow: hidden;line-height: 0;border-style: solid solid none;border-width: 3px 3px 2px;border-radius: 0px;border-color: rgb(33, 166, 210) rgb(33, 166, 210) rgb(15, 76, 129);\"><br  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 4px;padding-left: 4px;clear: right;box-shadow: rgb(0, 0, 0) 0px 0px 0px;min-height: 4.5em !important;\">\n<section 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style=\"letter-spacing: 0.544px;\"><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;\">\n<section style=\"width: 661px;\">\n<section style=\"clear: both;line-height: 0;\">\n<section style=\"line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;letter-spacing: 0.544px;white-space: normal;color: rgb(63, 63, 63);font-family: PingFangSC-light;font-size: 15px;background-color: rgb(255, 255, 255);text-align: center;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img data-type=\"png\" data-ratio=\"0.07314814814814814\" data-w=\"1080\"  style=\"box-sizing: border-box;vertical-align: middle;visibility: visible !important;width: 677px !important;\" src=\"\/wp-content\/uploads\/2021\/05\/wxsync-2021-05-e16cd5b776e38a4f6806c73548bdc7d4.png\"  \/><strong style=\"font-size: 13px;color: rgb(73, 73, 73);letter-spacing: 0.544px;text-align: right;\"><\/strong><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 0pt;margin-bottom: 0pt;letter-spacing: 0.544px;white-space: normal;line-height: 1.7;font-size: 11pt;font-family: PingFangSC-light;background-color: rgb(255, 255, 255);text-align: right;\">\n<p style=\"color: rgb(73, 73, 73);\"><span style=\"font-size: 13px;\">&nbsp;DrugAI&nbsp;<strong>|&nbsp;\u6765\u6e90<\/strong><\/span><\/p>\n<\/section>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><img data-ratio=\"0.7253814\" data-w=\"721\" data-type=\"png\"  style=\"box-sizing: border-box;vertical-align: middle;width: 677px !important;visibility: visible !important;\" src=\"\/wp-content\/uploads\/2021\/05\/wxsync-2021-05-5b17cd15617ad087cb161fb5bc933953.png\"  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4e8b\u60c5\u5e76\u4e0d\u662f\u8fd9\u6837\u5f00\u59cb\u7684\u3002\u83b1\u7eb3\u65af-\u9c8d\u6797\u4ece\u591a\u80bd\u94fe\u7684\u7acb\u4f53\u5316\u5b66\u8003\u8651\u5efa\u7acb\u7684\u4e8c\u7ea7\u7ed3\u6784\u6a21\u578b\uff0c\u4ee5\u53ca\u4e0d\u4e45\u4e4b\u540e\u8bc1\u660e\u8fd9\u79cd\u4e8c\u7ea7\u7ed3\u6784\u53ef\u4ee5\u88ab\u7ec4\u88c5\u6210\u03b1-\u89d2\u86cb\u767d\u548c\u80f6\u539f\u86cb\u767d\u7684\u4e09\u7ef4\u6a21\u578b\uff0c\u5bfc\u81f4\u4eba\u4eec\u671f\u5f85\u51e0\u4f55\u8003\u8651\u3001\u6a21\u578b\u5efa\u7acb\u548c\u53c2\u6570\u65b9\u7a0b\u7684\u7ed3\u5408\u53ef\u4ee5\u89e3\u51b3\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u539f\u7406\uff0c\u6b63\u5982\u4ed6\u4eec\u5df2\u7ecf\u4e3a\u6838\u9178\u505a\u7684\u90a3\u6837\u3002\u7136\u800c\uff0c\u7b2c\u4e00\u4e2a\u86cb\u767d\u8d28\u6676\u4f53\u7ed3\u6784\u53ca\u5176\u60ca\u4eba\u7684\u4e0d\u89c4\u5219\u6027\u4f7f\u4eba\u4eec\u8ba4\u8bc6\u5230\uff0c\u8fd9\u4e9b\u539f\u7406\u53ef\u80fd\u6bd4\u9884\u671f\u7684\u8981\u590d\u6742\u5f97\u591a\u3002<\/span><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5c3d\u7ba1\u5982\u6b64\uff0c\u572820\u4e16\u7eaa90\u5e74\u4ee3\u521d\uff0c\u4eba\u4eec\u5bf9\u901a\u8fc7\u7b80\u5316\u591a\u80bd\u94fe\u7684\u751f\u7269\u7269\u7406\u8868\u5f81\u548c\u7ebf\u7a0b\u6240\u53d6\u5f97\u7684\u8fdb\u5c55\u611f\u5230\u5174\u594b\uff0c\u8ba4\u4e3a\u5728\u4ece\u6c28\u57fa\u9178\u5e8f\u5217\u63a8\u65ad\u7ed3\u6784\u65b9\u9762\u53d6\u5f97\u4e86\u5feb\u901f\u3001\u51b3\u5b9a\u6027\u7684\u8fdb\u5c55\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u5728\u73b0\u5b9e\u751f\u6d3b\u4e2d\u7684\u5e94\u7528\u4e0e\u6b64\u5e76\u4e0d\u5339\u914d\uff0c\u800c\u4e14\u5f88\u660e\u663e\uff0c\u4e00\u4e9b\u62a5\u544a\u7684\u6210\u529f\u53ef\u80fd\u662f\u7531\u4e8e &#8220;\u540e\u9884\u6d4b&#8221;\uff0c\u5373\u9884\u6d4b\u8005\u5df2\u7ecf\u77e5\u9053\u5176\u7ed3\u6784\u7684\u76ee\u6807\u3002\u4e3a\u4e86\u83b7\u5f97\u5bf9\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u6280\u672f\u6c34\u5e73\u7684\u5ba2\u89c2\u8bc4\u4f30\uff0c\u7531\u9a6c\u91cc\u5170\u5927\u5b66\u7684John Moult\u9886\u5bfc\u7684\u4e00\u7ec4\u79d1\u5b66\u5bb6\u57281994\u5e74\u7ec4\u7ec7\u4e86\u4e00\u6b21\u5b9e\u9a8c\uff0c\u5373CASP<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u7ed3\u6784\u9884\u6d4b\u7684\u5173\u952e\u8bc4\u4f30\uff09<\/span><span style=\"font-size: 15px;\">\uff0c\u9884\u6d4b\u8005\u53ef\u4ee5\u5728\u4e00\u4e2a\u53cc\u76f2\u6846\u67b6\u5185\u8bc4\u4f30\u4ed6\u4eec\u7684\u65b9\u6cd5\u3002\u7ec4\u7ec7\u8005\u5c06\u6536\u96c6\u7ed3\u6784\u5c1a\u672a\u516c\u5e03<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u751a\u81f3\u5c1a\u672a\u5b8c\u5168\u786e\u5b9a\uff09<\/span><span style=\"font-size: 15px;\">\u7684\u86cb\u767d\u8d28\u5e8f\u5217\uff0c\u5e76\u5c06\u5176\u4f5c\u4e3a\u9884\u6d4b\u76ee\u6807\u63d0\u4f9b\u7ed9\u8ba1\u7b97\u79d1\u5b66\u5bb6\u3002\u7136\u540e\uff0c\u7ec4\u7ec7\u8005\u5c06\u628a\u63d0\u4ea4\u7684\u9884\u6d4b\u548c\u5df2\u89e3\u51b3\u7684\u7ed3\u6784\u4ea4\u7ed9\u8bc4\u4f30\u8005\uff0c\u8bc4\u4f30\u8005\u5bf9\u53c2\u4e0e\u9884\u6d4b\u7684\u56e2\u961f\u4e0d\u4e86\u89e3\uff0c\u53ea\u77e5\u9053\u7ec4\u53f7\u3002\u5728\u5b9e\u9a8c\u7ed3\u675f\u65f6<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u6bcf\u4e24\u5e74\u91cd\u590d\u4e00\u6b21\uff09<\/span><span style=\"font-size: 15px;\">\uff0c\u5c06\u4e3e\u884c\u4e00\u6b21\u4f1a\u8bae\uff0c\u8ba8\u8bba\u7ed3\u679c\u3002<\/span><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;\">CASP1\u662f\u4e00\u4e2a\u4ee4\u4eba\u6e05\u9192\u7684\u7ecf\u9a8c\uff0c\u56e0\u4e3a\u7ed3\u6784\u9884\u6d4b\u7684\u5de5\u5177\u88ab\u8bc1\u660e\u662f\u975e\u5e38\u949d\u7684\u3002\u7528\u7ec4\u7ec7\u8005\u7684\u8bdd\u8bf4\uff1a&#8221;\u8fd9\u4e9b\u9884\u6d4b\u51fa\u4e86\u5f88\u591a\u95ee\u9898\uff0c\u8fd9\u4e5f\u662f\u5b9e\u9a8c\u7684\u4e3b\u8981\u4ef7\u503c\u6240\u5728\u3002\u4e00\u4e2a\u53ef\u9760\u7684\u4fe1\u606f\u6765\u6e90\u662f\u4e0e\u76ee\u6807\u86cb\u767d\u76f8\u5173\u7684\u7ed3\u6784\uff0c\u5177\u6709\u5df2\u77e5\u7ed3\u6784\u7684\u4eb2\u5c5e\u7684\u76ee\u6807\u88ab\u5f52\u7c7b\u4e3a\u6700\u7b80\u5355\u7684\uff0c\u53ef\u4ee5\u901a\u8fc7\u540c\u6e90\u6a21\u677f\u4e0a\u7684\u5efa\u6a21\u83b7\u5f97\u3002\u7136\u800c\uff0c\u7531\u4e8e\u68c0\u6d4b\u548c\u76ee\u6807\u4e0e\u6a21\u677f\u6bd4\u5bf9\u7684\u9519\u8bef\uff0c\u8981\u5efa\u7acb\u4e00\u4e2a\u6bd4\u6700\u8fd1\u7684\u53ef\u7528\u6a21\u677f\u66f4\u63a5\u8fd1\u76ee\u6807\u7684\u6a21\u578b\u662f\u76f8\u5f53\u56f0\u96be\u7684\u3002\u5e94\u7528\u751f\u7269\u7269\u7406\u65b9\u6cd5\uff0c\u5982\u80fd\u91cf\u6700\u5c0f\u5316\uff0c\u4f3c\u4e4e\u53ea\u4f1a\u4f7f\u9519\u8bef\u66f4\u4e25\u91cd\u3002\u76f8\u5e94\u5730\uff0cCASP2\u589e\u52a0\u4e86\u5bf9\u66f4\u8fdc\u7684\u540c\u6e90\u7269\u7684\u68c0\u6d4b\u3001\u5efa\u6a21\u548c\u7ec6\u5316\u7684\u6295\u5165\u3002CASP2\u6bd4CASP1\u66f4\u6210\u529f\uff0c\u7279\u522b\u662f\u5728CASP1\u9884\u6d4b\u57fa\u672c\u4e0a\u662f\u968f\u673a\u7684\u3001\u7ed3\u6784\u6570\u636e\u5e93\u4e2d\u7f3a\u4e4f\u53ef\u68c0\u6d4b\u6a21\u677f\u7684\u8f83\u96be\u76ee\u6807\uff0c\u4f46\u8fdb\u5c55\u4ecd\u7136\u6709\u9650\u3002\u300a\u7ebd\u7ea6\u65f6\u62a5\u300b\u4ee5 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15px;\">\u5728\u6b64\u57fa\u7840\u4e0a\uff0cCASP3-5\u5b9e\u9a8c\u63d0\u4f9b\u4e86\u8fdb\u4e00\u6b65\u7684\u6539\u8fdb\uff0c\u7136\u800c\uff0c\u4e3b\u8981\u662f\u5728\u4e2d\u7b49\u96be\u5ea6\u7684\u9776\u6807\u9886\u57df\uff0c\u901a\u8fc7\u4e00\u7cfb\u5217\u65e5\u76ca\u5f3a\u5927\u7684\u5e8f\u5217\u641c\u7d22\u5de5\u5177\uff0c\u53ef\u4ee5\u68c0\u6d4b\u5230\u66f4\u52a0\u9065\u8fdc\u7684\u540c\u6e90\u7269\u3002\u4e8b\u5b9e\u8bc1\u660e\uff0c\u540c\u6e90\u86cb\u767d\u57fa\u672c\u4e0a\u4fdd\u6301\u7740\u76f8\u540c\u7684\u6298\u53e0\uff0c\u5373\u4f7f\u5b83\u4eec\u7684\u5e8f\u5217\u4f3c\u4e4e\u5df2\u7ecf\u5206\u5316\u5230\u4e86\u4e0d\u76f8\u4f3c\u7684 &#8220;\u5348\u591c\u533a&#8221;\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5c06\u751f\u7269\u7269\u7406\u53c2\u6570\u7eb3\u5165\u9884\u6d4b\u65b9\u6cd5\u7684\u52aa\u529b\uff0c\u867d\u7136\u4e3a\u8f83\u5c0f\u7684\u9776\u6807\u63d0\u4f9b\u4e86\u4e00\u4e9b\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u6210\u529f\uff0c\u4f46\u5e76\u6ca1\u6709\u6269\u5c55\u5230\u8f83\u5927\u7684\u9776\u6807\uff0c\u4f7f\u8fdb\u5316\u76f8\u5173\u5ea6\u7684\u7edf\u8ba1\u68c0\u6d4b\u6210\u4e3a\u7ed3\u6784\u9884\u6d4b\u7684\u4e3b\u8981\u5de5\u5177\u3002<\/span><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;\">CASP3\u4e2d\u5f15\u5165\u7684\u6a21\u578b\u51c6\u786e\u6027\u6d4b\u91cf\u65b9\u6cd5GDT-TS<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u5168\u5c40\u8ddd\u79bb\u6d4b\u8bd5-\u603b\u5206\uff09<\/span><span style=\"font-size: 15px;\">\uff0c\u53ef\u4ee5\u6bd4\u8f83\u5b9e\u9a8c\u5185\u90e8\u548c\u5b9e\u9a8c\u4e4b\u95f4\u7684\u7ed3\u679c\u3002\u5728\u5bf9\u4e24\u4e2a\u5177\u6709\u76f8\u540c\u5e8f\u5217\u7684\u7ed3\u6784\u8fdb\u884c\u8fed\u4ee3\u53e0\u52a0\u540e\uff0c\u8be5\u65b9\u6cd5\u6bd4\u8f83\u4e86\u540c\u6e90\u7684C\u03b1\u78b3\u7684\u4f4d\u7f6e\uff0c\u7edf\u8ba1\u4e86\u57281\u30012\u30014\u548c8\u00c5\u7684\u8ddd\u79bb\u5206\u754c\u7ebf\u5185\u7684\u914d\u5bf9\u767e\u5206\u6bd4\uff0c\u5c06\u767e\u5206\u6bd4\u76f8\u52a0\u5e76\u9664\u4ee54\u3002\u8fd9\u79cd\u5bf9\u76f8\u4f3c\u6027\u7684\u5173\u6ce8\u4f7f\u8be5\u6d4b\u91cf\u65b9\u6cd5\u80fd\u591f\u5c06\u90a3\u4e9b\u5dee\u7684\u3001\u4f46\u5305\u542b\u5c40\u90e8\u6b63\u786e\u7247\u6bb5\u7684\u6a21\u578b\u4e0e\u5168\u5c40\u9519\u8bef\u7684\u6a21\u578b\u533a\u5206\u5f00\u6765\uff0c\u8fd9\u662f\u5176\u4ed6\u76f8\u5173\u6d4b\u91cf\u65b9\u6cd5<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u5982\u5747\u65b9\u6839\u504f\u5dee\uff09<\/span><span style=\"font-size: 15px;\">\u6240\u4e0d\u80fd\u5b9e\u73b0\u7684\u3002\u975e\u5e38\u7c97\u7565\u7684\u8bf4\uff0cGDT-TS\u7684\u5f97\u5206\u572820\u5206\u5de6\u53f3\uff0c\u8868\u793a\u5927\u4f53\u4e0a\u662f\u968f\u673a\u7684\u6a21\u578b\uff0c\u5f97\u5206\u572850\u5206\u5de6\u53f3\uff0c\u5177\u6709\u6574\u4f53\u6b63\u786e\u62d3\u6251\u7ed3\u6784\u7684\u6a21\u578b\uff0c\u5f97\u5206\u572870\u5206\u5de6\u53f3\uff0c\u5177\u6709\u51c6\u786e\u7684\u5168\u5c40\u548c\u5c40\u90e8\u62d3\u6251\u7ed3\u6784\u7684\u6a21\u578b\u3002\u8d85\u8fc780\u5206\uff0c\u7ed3\u6784\u7ec6\u8282\u7684\u5efa\u6a21\u8d8a\u6765\u8d8a\u6b63\u786e\uff0c\u8d85\u8fc795\u5206\uff0c\u6a21\u578b\u5c31\u50cf\u6839\u636e\u5b9e\u9a8c\u6570\u636e\u5efa\u7acb\u7684\u6a21\u578b\u4e00\u6837\u51c6\u786e\u3002<\/span><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;\">John Moult\u5728CASP14\u4f1a\u8bae\u7684\u4ecb\u7ecd\u4e2d\u63d0\u51fa\u4e86CASP\u5355\u4e2a\u5b9e\u9a8c\u4e2dGDT-TS\u5f97\u5206\u7684\u6982\u8ff0\uff0c\u663e\u793a\u4e3a\u901a\u8fc7\u8be5\u5b9e\u9a8c\u4e2d\u6bcf\u4e2a\u76ee\u6807\u53d6\u5f97\u7684\u6700\u4f73\u5f97\u5206\u7684\u591a\u9879\u5f0f\u62df\u5408<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08https:\/\/en.wikipedia.org\/wiki\/AlphaFold#\/media\/File:CASP_results_2020.png\uff09<\/span><span style=\"font-size: 15px;\">\u3002\u8fd9\u4e00\u6982\u8ff0\u8868\u660e\uff0c\u5728CASP5\u4e4b\u540e\uff0c\u6574\u4f53\u8fdb\u5c55\u57fa\u672c\u4e0a\u505c\u6ede\u4e0d\u524d\uff0c\u76f4\u5230CASP12\uff0c\u5bfc\u81f4\u8be5\u9886\u57df\u7684\u4e00\u4e9b\u4eba\u6000\u7591\u6211\u4eec\u662f\u5426\u4f1a\u5f97\u5230\u95ee\u9898\u7684\u89e3\u51b3\u3002\u7136\u800c\uff0c\u4e0b\u4e00\u6b65\u8fdb\u5c55\u7684\u79cd\u5b50\u5df2\u7ecf\u64ad\u4e0b\u3002<\/span><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><img data-ratio=\"0.7136061\" data-w=\"1051\" data-type=\"png\"  style=\"box-sizing: border-box;vertical-align: middle;width: 677px !important;visibility: visible !important;\" src=\"\/wp-content\/uploads\/2021\/05\/wxsync-2021-05-2cd231a37ca46a5f0356e04ae8197541.png\"  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4eceCASP\u5b9e\u9a8c\u5f00\u59cb\uff0c\u79d1\u5b66\u5bb6\u4eec\u5c31\u60f3\u77e5\u9053\u662f\u5426\u6709\u53ef\u80fd\u4ece\u540c\u6e90\u86cb\u767d\u8d28\u7684\u591a\u5e8f\u5217\u6bd4\u5bf9\u4e2d\u7684\u76f8\u5173\u7a81\u53d8\u8ba1\u7b97\u51fa\u6b8b\u57fa\u95f4\u7684\u63a5\u89e6\u56fe\uff0c\u4ee5\u83b7\u5f97\u6298\u53e0\u7684\u6307\u7eb9\u5e76\u6307\u5bfc\u7ed3\u6784\u9884\u6d4b\u3002\u7814\u7a76\u4eba\u5458\u7684\u60f3\u6cd5\u662f\uff0c\u5982\u679c\u7a81\u53d8\u662f\u76f8\u5173\u7684\uff0c\u90a3\u4e48\u8fd9\u4e9b\u4f4d\u7f6e\u7684\u6b8b\u57fa\u5f88\u53ef\u80fd\u662f\u7269\u7406\u63a5\u89e6\u7684\uff0c\u63d0\u4f9b\u7684\u4fe1\u606f\u53ef\u4ee5\u901a\u8fc7\u6838\u78c1\u5171\u632f\u786e\u5b9a\u7ed3\u6784\u3002\u7136\u800c\uff0c\u591a\u5e74\u6765\uff0c\u8fd9\u79cd\u63a5\u89e6\u56fe\u7684\u51c6\u786e\u6027\u4ecd\u7136\u5f88\u4f4e\uff0c\u56e0\u4e3a\u4ee5\u6210\u5bf9\u7684\u65b9\u5f0f\u5206\u6790\u76f8\u5173\u6027\uff0c\u65e0\u6cd5\u533a\u5206\u76f4\u63a5\u7684\u3001\u7ed3\u6784\u6027\u7684\u76f8\u5173\u6027\u548c\u95f4\u63a5\u7684\u3001\u529f\u80fd\u6027\u7684\u76f8\u5173\u6027\u3002\u4ece2010\u5e74\u5de6\u53f3\u5f00\u59cb\uff0c\u901a\u8fc7\u4f7f\u7528\u76f4\u63a5\u8026\u5408\u5206\u6790\u8fdb\u884c\u5168\u5c40\u63a5\u89e6\u9884\u6d4b\uff0c\u53ef\u4ee5\u66f4\u597d\u5730\u533a\u5206\u4e0d\u540c\u7684\u5171\u540c\u6f14\u5316\u7684\u6b8b\u57fa\uff0c\u8be5\u65b9\u6cd5\u540c\u65f6\u8003\u8651\u4e86\u6240\u6709\u6210\u5bf9\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u6839\u636e\u89c2\u5bdf\u5230\u7684\u6210\u5bf9\u7684\u76f8\u5173\u6027\u5bf9\u63a5\u89e6\u56fe\u8fdb\u884c\u5168\u5c40\u4f18\u5316\u3002\u8fd9\u79cd\u65b9\u6cd5\u57282017\u5e74\u53c8\u5411\u524d\u8fc8\u8fdb\u4e86\u4e00\u5927\u6b65\uff0c\u8bc1\u660e\u4e86\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u4e0d\u4ec5\u53ef\u4ee5\u901a\u8fc7\u8fd9\u79cd\u65b9\u5f0f\u4ece\u591a\u4e2a\u6392\u5217\u4e2d\u63d0\u53d6\u9ad8\u8d28\u91cf\u7684\u63a5\u89e6\u56fe\uff0c\u751a\u81f3\u5728\u540c\u6e90\u7269\u5f88\u5c11\u7684\u60c5\u51b5\u4e0b\u4e5f\u53ef\u4ee5\u5c06\u9884\u6d4b\u7684\u63a5\u89e6\u89e3\u91ca\u4e3a\u4e00\u7ec4\u8ddd\u79bb\uff0c\u4ece\u800c\u4e3a\u57fa\u7840\u6298\u53e0\u63d0\u4f9b\u66f4\u7cbe\u7ec6\u7684\u51e0\u4f55\u6307\u7eb9\u3002\u5377\u79ef\u795e\u7ecf\u7f51\u7edc\u5728\u8ddd\u79bb\u56fe\u9884\u6d4b\u4e2d\u7684\u5e94\u7528\u88ab\u9886\u5148\u7684\u7ed3\u6784\u9884\u6d4b\u5c0f\u7ec4\u5728CASP13<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff082018\uff09<\/span><span style=\"font-size: 15px;\">\u4e2d\u4f7f\u7528\uff0c\u5e76\u5bf9\u786c\u4ea7\u751f\u4e86\u5f3a\u5927\u7684\u5f71\u54cd\uff0c\u5bf9\u4e8e\u8fd9\u4e9b\u76ee\u6807\uff0c\u6700\u4f73\u6a21\u578b\u7684GDT-TS\u4ece40\u5de6\u53f3\u4e0a\u5347\u523060\u4ee5\u4e0a\u3002<\/span><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728CASP13\u7684\u9ad8\u5206\u5c0f\u7ec4\u4e2d\uff0c\u6709\u4e00\u4e2a\u51fa\u4e4e\u610f\u6599\u7684\u65b0\u6210\u5458AlphaFold\uff0c\u7531Alphabet\u516c\u53f8\u7684\u9886\u5148\u4eba\u5de5\u667a\u80fd\u5b9e\u9a8c\u5ba4DeepMind\u6d3e\u51fa\u3002\u4ee4\u6240\u6709\u4eba\u60ca\u8bb6\u7684\u662f\uff0c\u8fd9\u4e2a\u5c0f\u7ec4\u4ee5\u5176\u5173\u952e\u7684\u6d1e\u5bdf\u529b\u51fb\u8d25\u4e86\u6240\u6709\u53c2\u8d5b\u8005\uff0c\u5373\u8ddd\u79bb\u56fe\u7684\u6982\u7387\u5206\u5e03\u53ef\u4ee5\u8f6c\u6362\u4e3a\u7279\u5b9a\u86cb\u767d\u8d28\u7684\u7edf\u8ba1\u6f5c\u529b\uff0c\u4ece\u800c\u901a\u8fc7\u6700\u5c0f\u5316\u751f\u6210\u86cb\u767d\u8d28\u6298\u53e0\u3002\u867d\u7136AlphaFold\u5728CASP13\u4e2d\u7684\u9886\u5148\u4f18\u52bf\u6bd4\u4ee5\u5f80CASP\u5b9e\u9a8c\u4e2d\u6392\u540d\u7b2c\u4e00\u548c\u7b2c\u4e8c\u7684\u5c0f\u7ec4\u4e4b\u95f4\u7684\u5178\u578b\u8ddd\u79bb\u8981\u5927\uff0c\u4f46\u5b83\u7684\u603b\u4f53\u8868\u73b0\u662f\u9012\u589e\u6027\u7684\uff0c\u800c\u4e0d\u662f\u53d8\u9769\u6027\u7684\uff0c\u53ea\u5728\u5927\u7ea6\u4e09\u5206\u4e4b\u4e00\u7684\u60c5\u51b5\u4e0b\u63d0\u4f9b\u4e86\u6700\u4f73\u6a21\u578b\uff0c\u5c3d\u7ba1\u5bf9\u8f83\u96be\u7684\u76ee\u6807\u7684\u9886\u5148\u4f18\u52bf\u5927\u4e8e\u5bf9\u8f83\u6613\u7684\u76ee\u6807\u7684\u9886\u5148\u4f18\u52bf\u3002<\/span><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><img data-ratio=\"0.5724234\" data-w=\"718\" data-type=\"png\"  style=\"box-sizing: border-box;vertical-align: middle;width: 677px !important;visibility: visible !important;\" src=\"\/wp-content\/uploads\/2021\/05\/wxsync-2021-05-bfe1d5782999c43d5b352ef50d992894.png\"  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u56e0\u6b64\uff0c\u6ca1\u6709\u4eba\u51c6\u5907\u597d\u8fce\u63a5AlphaFold\u7684\u7b2c\u4e8c\u4e2a\u5316\u8eabAlphaFold2\u5728CASP14\u4e0a\u7684\u53d8\u9769\u6027\u8868\u73b0\uff0c\u5b83\u8fdc\u8fdc\u9886\u5148\u4e8e\u6240\u6709\u5176\u4ed6\u53c2\u4e0e\u8005\uff0c\u5176\u9884\u6d4b\u7684GDT-TS\u4e2d\u503c\u8fbe\u5230\u4e8692.4! \u56de\u987e\u4e00\u4e0b\uff0c\u8fd9\u662f\u5728\u5b9e\u9a8c\u7ed3\u6784\u7684\u8303\u56f4\u5185\uff0c\u5bfc\u81f4\u8bb8\u591a\u4eba\u5f97\u51fa\u7ed3\u8bba\uff0c\u5355\u6761\u86cb\u767d\u8d28\u94fe\u7684\u7ed3\u6784\u9884\u6d4b\u95ee\u9898\u73b0\u5728\u5df2\u7ecf\u89e3\u51b3\u4e86\uff0c\u6b63\u5982John Moult\u5728CASP14\u4f1a\u8bae\u7684\u603b\u7ed3\u53d1\u8a00\u4e2d\u6240\u8bf4\u3002\u5c06AlphaFold2\u7684\u9884\u6d4b\u7ed3\u679c\u4e0e\u5176\u4ed6\u7814\u7a76\u5c0f\u7ec4\u63d0\u4ea4\u7684\u6700\u4f73\u6a21\u578b\u8fdb\u884c\u6bd4\u8f83\uff0c\u53ef\u4ee5\u6e05\u695a\u5730\u770b\u5230\u8fdb\u6b65\u7684\u7a0b\u5ea6\uff0c\u56e0\u4e3aAlphaFold2\u7684\u9884\u6d4b\u7ed3\u679c\u901a\u5e38\u662fGDT-TS\u5f97\u5206&gt;80\uff0c\u5373\u4f7f\u662f\u6700\u96be\u7684\u76ee\u6807\uff0c\u800c\u8fd9\u4e9b\u76ee\u6807\u7684\u7b2c\u4e8c\u597d\u7684\u6a21\u578b\u90fd\u4f4e\u4e8e60\u3002<\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4e3a\u4e86\u8bf4\u660e\u8fd9\u4e00\u70b9\uff0c\u7b80\u5355\u4ecb\u7ecd\u4e00\u4e0b\u76ee\u6807T1100\u7684\u60c5\u51b5\uff0c\u8fd9\u662f\u4e00\u4e2a\u53e4\u751f\u7269\u8de8\u819c\u53d7\u4f53\uff0cAlphaFold2\u4e3a\u5176\u63d0\u4ea4\u4e86\u4e00\u4e2aGDT-TS\u7ea6\u4e3a80\u7684\u6a21\u578b\uff0c\u800c\u63a5\u4e0b\u6765\u6700\u597d\u7684\u4e00\u7ec4\u6a21\u578b\u7684GDT-TS\u7ea6\u4e3a55\u3002\u7814\u7a76\u4eba\u5458\u7684\u5c0f\u7ec4\u8fdb\u5165\u8fd9\u4e2a\u76ee\u6807\u662f\u7531\u4e8e2020\u5e748\u6708\u7ec4\u7ec7\u8005\u548c\u8bc4\u5ba1\u5458\u7684\u4e00\u6b21\u5728\u7ebf\u4f1a\u8bae\uff0c\u5728\u8fd9\u6b21\u4f1a\u8bae\u4e0a\uff0c\u8bc4\u5ba1\u5458\u4e4b\u4e00Nick Grishin\u5c06427\u5c0f\u7ec4<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u540e\u6765\u53d1\u73b0\u662fAlphaFold2\uff09<\/span><span style=\"font-size: 15px;\">\u7684\u60ca\u4eba\u9884\u6d4b\u7b80\u6d01\u5730\u63d0\u5230\u4e86\u4e00\u4e2a\u70b9\u4e0a\u3002\u6240\u4ee5\uff0c\u8981\u4e48\u8fd9\u4e2a\u5c0f\u7ec4\u63a5\u8fd1\u89e3\u51b3\u6298\u53e0\u95ee\u9898\uff0c\u8981\u4e48\u4ed6\u4eec\u4ee5\u67d0\u79cd\u65b9\u5f0f\u4f5c\u5f0a&#8221;\u3002\u4f5c\u4e3a\u56de\u5e94\uff0c\u7814\u7a76\u8005\u63d0\u5230\u6709\u4e00\u4e2a\u8de8\u819c\u53d7\u4f53\u7684\u884d\u5c04\u6570\u636e\uff0c\u7531\u4e8e\u76f8\u4f4d\u95ee\u9898\uff0c\u51e0\u4e4e\u5341\u5e74\u90fd\u6ca1\u6709\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\u3002427\u7ec4\u6587\u4ef6\u6a21\u578b\u662f\u5426\u8db3\u4ee5\u901a\u8fc7\u5206\u5b50\u7f6e\u6362\u89e3\u51b3\u8be5\u6570\u636e\u96c6\uff1f\u5f53\u7136\uff0c\u8fd9\u662f\u4e0d\u53ef\u80fd\u4f5c\u5f0a\u7684\u3002\u7b80\u800c\u8a00\u4e4b\uff0c\u7528AlphaFold2\u6a21\u578b\u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u89e3\u51b3\u8fd9\u4e2a\u7ed3\u6784\u3002\u5176\u4ed6\u63d0\u4ea4\u7684\u6a21\u578b\u6709\u5f88\u597d\u7684\u6574\u4f53\u62d3\u6251\u7ed3\u6784\uff0c\u4f46\u6709\u5f88\u591a\u5730\u65b9\u504f\u79bb\u4e86\u7ed3\u6784\uff0c\u4f7f\u5b83\u4eec\u6210\u4e3a\u5206\u5b50\u7f6e\u6362\u7684\u4e0d\u826f\u6a21\u677f\u3002\u4f5c\u4e3a\u4e00\u4e2a\u6709\u8da3\u7684\u4fa7\u9762\uff0c\u5728\u8fd9\u4e2a20\u4e2a\u6392\u540d\u6700\u9ad8\u7684\u5c0f\u7ec4\u4e2d\uff0c\u670912\u4e2aserver\u63d0\u4ea4\u4e86\u4e00\u4e2a\u516c\u5171\u9884\u6d4b\u670d\u52a1\u5668\u7684\u9884\u6d4b\u5750\u6807\u4f5c\u4e3a\u4ed6\u4eec\u7684\u6700\u4f73\u7b54\u6848\uff0c\u5076\u5c14\u4e5f\u6709\u4e00\u4e9b\u7ec6\u5316\u7684\u5c1d\u8bd5\u3002\u5176\u4e2d\u4e00\u4e2a\u670d\u52a1\u5668\u540d\u4e3atFold\uff0c\u7531\u4e2d\u56fd\u79d1\u6280\u516c\u53f8\u817e\u8baf\u7684\u4eba\u5de5\u667a\u80fd\u5b9e\u9a8c\u5ba4\u8fd0\u8425\uff0c\u8fd9\u8868\u660eDeepMind\u5e76\u4e0d\u662f\u552f\u4e00\u6709\u5174\u8da3\u52a0\u5165\u8fd9\u4e00\u6218\u5c40\u7684\u516c\u53f8\u5b9e\u9a8c\u5ba4\u3002<\/span><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><img data-ratio=\"0.9323529\" data-w=\"680\" data-type=\"png\"  style=\"box-sizing: border-box;border-width: 0px;border-style: solid;border-color: rgb(238, 237, 235);vertical-align: middle;background-color: rgb(238, 237, 235) !important;background-size: 22px !important;background-position: center center !important;background-repeat: no-repeat !important;height: 631.338px !important;width: 677px !important;\" src=\"\/wp-content\/uploads\/2021\/05\/wxsync-2021-05-8fc1b8c648a5c127966261c6e2d0ad13.png\"  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u662f\u4ec0\u4e48\u8ba9AlphaFold2\u5efa\u7acb\u4e86\u8fd9\u79cd\u9886\u5148\u4f18\u52bf\uff1f\u66f4\u8be6\u7ec6\u7684\u8bc4\u4f30\u8981\u7b49CASP14\u8bba\u6587\u96c6\u4e2d\u7684\u65b9\u6cd5\u53d1\u8868\u540e\u624d\u80fd\u8fdb\u884c\uff0c\u4f46\u4eceJohn Jumper\u4ee3\u8868AlphaFold2\u56e2\u961f\u5728CASP14\u4f1a\u8bae\u4e0a\u7684\u53d1\u8a00\u4ee5\u53ca\u8be5\u9886\u57df\u4e13\u5bb6\u7684\u610f\u89c1\u6765\u770b\uff0c\u9884\u6d4b\u7f51\u7edc\u7684\u67b6\u6784\u5df2\u7ecf\u53d1\u751f\u4e86\u6839\u672c\u6027\u7684\u53d8\u5316\u3002AlphaFold\u4f7f\u7528\u5377\u79ef\u795e\u7ecf\u7f51\u7edc\u8fdb\u884c\u8ddd\u79bb\u56fe\u9884\u6d4b\uff0c\u5e76\u5e94\u7528\u68af\u5ea6\u4e0b\u964d\u4f18\u5316\u6cd5\u4ece\u8fd9\u4e9b\u7ea6\u675f\u6761\u4ef6\u4e2d\u6784\u5efa\u6a21\u578b\uff0c\u800cAlphaFold2\u6784\u5efa\u4e86\u4e00\u4e2a\u7aef\u5230\u7aef\u7684\u7f51\u7edc\uff0c\u4ece\u5e8f\u5217\u8f93\u5165\u5230\u7ed3\u6784\u8f93\u51fa\uff0c\u6a21\u578b\u53c2\u6570\u53ef\u4ee5\u5171\u540c\u8c03\u6574\uff0c\u4ee5\u4f18\u5316\u6700\u7ec8\u6a21\u578b\uff0c\u800c\u4e0d\u662f\u6cbf\u9014\u7684\u4ee3\u7406\u63aa\u65bd\u3002\u8fd9\u79cd\u7528\u4e8e\u7f51\u7edc\u4f18\u5316\u7684\u7aef\u5230\u7aef\u8bad\u7ec3\u662f\u7531Mohammed Al 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powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\">\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8fd9\u662f\u5426\u610f\u5473\u7740AlphaFold2\u83b7\u5f97\u7684\u8fdb\u6b65\u88ab\u5938\u5927\u4e86\uff0c\u4e8b\u5b9e\u4e0a\u5e76\u4e0d\u5c3d\u5982\u4eba\u610f\uff1f\u5bf9\u8fd9\u4e00\u70b9\u4e5f\u80af\u5b9a\u662f\u5426\u5b9a\u7684\u3002\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u8fd9\u4e00\u8fdb\u5c55\u7edd\u5bf9\u662f\u4ee4\u4eba\u9707\u60ca\u7684\uff0c\u8fd9\u4e00\u70b9\u6211\u4eec\u5728CASP14\u7684\u5a92\u4f53\u62a5\u9053\u4e2d\u53cd\u590d\u5f3a\u8c03\u3002\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\uff0c\u5b9e\u73b0\u8fd9\u4e00\u7a81\u7834\u7684\u6f2b\u957f\u800c\u8270\u8f9b\u7684\u5386\u7a0b\uff0c\u6d89\u53ca\u5230\u751f\u7269\u7269\u7406\u5b66\u548c\u8ba1\u7b97\u751f\u7269\u5b66\u4e2d\u4e00\u4e9b\u6700\u806a\u660e\u7684\u5934\u8111\uff0c\u5145\u5206\u8bc1\u660e\u4e86\u8fd9\u4e00\u6210\u5c31\u7684\u5de8\u5927\u3002\u4e8b\u5b9e\u4e0a\uff0c\u8fd9\u4e00\u8fdb\u5c55\u9700\u8981\u5f15\u5165\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\uff0c\u8fd9\u4fc3\u4f7f\u6211\u4eec\u95ee\u9053\uff0c\u7ed3\u6784\u9884\u6d4b\u95ee\u9898\u5bf9\u4e8e\u4eba\u7c7b\u7684\u5927\u8111\u6765\u8bf4\u662f\u5426\u592a\u96be\u89e3\u51b3\u3002\u5957\u7528J.B.S. Haldane\u7684\u8bdd\uff0c\u4ed6\u6000\u7591\u5b87\u5b99\u4e0d\u4ec5\u6bd4\u6211\u4eec\u60f3\u8c61\u7684\u8981\u5947\u602a\uff0c\u800c\u4e14\u6bd4\u6211\u4eec\u80fd\u60f3\u8c61\u7684\u8981\u5947\u602a\uff0c\u8fd9\u4e2a\u95ee\u9898\u53ef\u80fd\u6bd4\u6211\u4eec\u80fd\u89e3\u51b3\u7684\u8981\u96be\uff1f<\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7814\u7a76\u4eba\u5458\u62c5\u5fc3\u60c5\u51b5\u786e\u5b9e\u5982\u6b64\uff0c\u7aef\u5230\u7aef\u8bad\u7ec3\u6210\u529f\u7684\u539f\u56e0\u4e4b\u4e00\u662f\u6d88\u9664\u4e86\u4eba\u7c7b\u7684\u504f\u89c1\u3002\u8bad\u7ec3\u6709\u7d20\u7684\u79d1\u5b66\u5bb6\u6570\u5341\u5e74\u7684\u52aa\u529b\u548c\u8bb8\u591a\u6570\u5341\u4ebf\u7f8e\u5143\u7684\u516c\u5171\u6295\u8d44\u663e\u7136\u4ea7\u751f\u4e86\u7a81\u7834\u95ee\u9898\u6240\u9700\u7684\u6570\u636e\uff0c\u4f46\u8fd9\u4e00\u7a81\u7834\u9700\u8981\u8ba1\u7b97\u7f51\u7edc\uff0c\u800c\u8ba1\u7b97\u7f51\u7edc\u4e0e\u4eba\u8111\u4e0d\u540c\uff0c\u662f\u4e3a\u5206\u6790\u975e\u7ebf\u6027\u76f8\u5173\u5173\u7cfb\u800c\u4f18\u5316\u3002\u5c31\u50cf\u8bb8\u591a\u5176\u4ed6\u7fa4\u4f53\u4e00\u6837&#8211;\u8fd0\u52a8\u5458\u548c\u56fd\u9645\u8c61\u68cb\u9009\u624b\u5c31\u662f\u5176\u4e2d\u4e4b\u4e00&#8211;\u6211\u4eec\u5c06\u4e0d\u5f97\u4e0d\u4e60\u60ef\u4e8e\u673a\u5668\u62e5\u6709\u8d85\u51fa\u6211\u4eec\u751f\u7269\u8303\u56f4\u7684\u80fd\u529b\u8fd9\u4e00\u4e8b\u5b9e\u3002\u6211\u4eec\u671f\u5f85\u7740\u6211\u4eec\u8ba4\u4e3a\u5c06\u662f\u4e00\u6ce2\u5148\u8fdb\u7684\u9884\u6d4b\u670d\u52a1\u5668\uff0c\u65e2\u6765\u81ea\u9886\u5148\u7684\u5b66\u672f\u56e2\u4f53\uff0c\u4e5f\u6765\u81ea\u5177\u6709\u5148\u8fdb\u673a\u5668\u5b66\u4e60\u80fd\u529b\u7684\u516c\u53f8\uff0c\u8fd9\u5c06\u4f7f\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u7a7a\u95f4\u50cf25\u5e74\u524dBLAST\u5bf9\u5e8f\u5217\u7a7a\u95f4\u6240\u505a\u7684\u90a3\u6837\u5e7f\u6cdb\u800c\u8fc5\u901f\u5730\u88ab\u8bbf\u95ee\uff0c\u6807\u5fd7\u7740\u751f\u547d\u79d1\u5b66\u7684\u7c7b\u4f3c\u9769\u547d\u3002<\/span><\/p>\n<\/section>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong><span style=\"font-size: 15px;color: rgb(61, 170, 214);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/strong><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 13px;color: rgb(136, 136, 136);\">Andrei N. Lupas, Joana Pereira, Vikram Alva, Felipe Merino, Murray Coles, Marcus D. Hartmann; The breakthrough in protein structure prediction. Biochem J 28 May 2021; 478 (10): 1885\u20131890.&nbsp;<\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;line-height: 1.75em;\"><span style=\"font-size: 13px;color: rgb(136, 136, 136);\">doi: https:\/\/doi.org\/10.1042\/BCJ20200963<\/span><\/p>\n<section style=\"margin-left: 8px;margin-right: 8px;\"><br  \/><\/section>\n<section style=\"margin-left: 8px;margin-right: 8px;\"><br  \/><\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;letter-spacing: 0.544px;white-space: normal;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);text-align: center;justify-content: center;\">\n<section style=\"display: inline-block;width: auto;vertical-align: top;min-width: 10%;height: auto;box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-bottom: 9px solid rgb(169, 215, 227);border-bottom-right-radius: 0px;\">\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: -15px;\">\n<section style=\"padding-right: 10px;padding-left: 10px;color: rgb(12, 130, 169);font-size: 16px;line-height: 2;letter-spacing: 3px;\">\n<p><strong>\u590d\u6742\u79d1\u5b66\u6700\u65b0\u8bba\u6587<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"letter-spacing: 0.544px;white-space: normal;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);\">\n<p><br style=\"color: rgb(63, 63, 63);font-family: PingFangSC-light;font-size: 15px;letter-spacing: 0.544px;\"  \/><\/p>\n<\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;letter-spacing: 0.544px;white-space: normal;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u96c6\u667a\u6591\u56fe\u9876\u520a\u8bba\u6587\u901f\u9012\u680f\u76ee\u4e0a\u7ebf\u4ee5\u6765\uff0c\u6301\u7eed\u6536\u5f55\u6765\u81ea<span style=\"font-style: italic;\">Nature\u3001Science<\/span>\u7b49\u9876\u520a\u7684\u6700\u65b0\u8bba\u6587\uff0c\u8ffd\u8e2a\u590d\u6742\u7cfb\u7edf\u3001\u7f51\u7edc\u79d1\u5b66\u3001\u8ba1\u7b97\u793e\u4f1a\u79d1\u5b66\u7b49\u9886\u57df\u7684\u524d\u6cbf\u8fdb\u5c55\u3002\u73b0\u5728\u6b63\u5f0f\u63a8\u51fa\u8ba2\u9605\u529f\u80fd\uff0c\u6bcf\u5468\u901a\u8fc7\u5fae\u4fe1\u670d\u52a1\u53f7\u300c\u96c6\u667a\u6591\u56fe\u300d\u63a8\u9001\u8bba\u6587\u4fe1\u606f\u3002\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\u5373\u53ef\u4e00\u952e\u8ba2\u9605\uff1a<\/span><br  \/><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;letter-spacing: 0.544px;white-space: normal;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);text-align: center;\"><img class=\"rich_pages\" data-ratio=\"0.3088962108731466\" data-s=\"300,640\" data-type=\"png\" data-w=\"1214\"  style=\"box-sizing: border-box !important;visibility: visible !important;width: 677px !important;\" src=\"\/wp-content\/uploads\/2021\/05\/wxsync-2021-05-fdadfa689e4fd2c0d00404fdcd994125.png\"  \/><\/section>\n<section powered-by=\"xiumi.us\" style=\"letter-spacing: 0.544px;white-space: normal;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);\">\n<p style=\"margin-right: 8px;margin-bottom: 5px;margin-left: 8px;\"><br  \/><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 5px;margin-left: 8px;\"><br  \/><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 5px;margin-left: 8px;\"><strong style=\"letter-spacing: 0.544px;color: rgb(0, 0, 0);font-size: 16px;text-align: center;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\"><span style=\"font-size: 15px;letter-spacing: 0.544px;\">\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><br  \/><\/p>\n<ul class=\"list-paddingleft-2\">\n<li style=\"font-size: 14px;font-weight: bold;\">\n<p style=\"margin-right: 8px;margin-bottom: 5px;margin-left: 8px;text-align: left;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247520884&amp;idx=1&amp;sn=d463490d6336c23c8ca95203066fa15e&amp;chksm=e897c8f9dfe041ef55fcd02050c6fd54e14e8549dee6d6b167df4ee0004ec4e9057f1c607854&amp;scene=21#wechat_redirect\" data-itemshowtype=\"0\" tab=\"innerlink\" style=\"text-decoration: underline;\" data-linktype=\"2\" rel=\"noopener noreferrer\">\u4e3a\u4ec0\u4e48\u795e\u7ecf\u7f51\u7edc\u96be\u4ee5\u7406\u89e3\u751f\u547d\u6e38\u620f\uff1f<\/a><br  \/><\/p>\n<\/li>\n<li style=\"font-size: 14px;font-weight: bold;\">\n<p style=\"margin-right: 8px;margin-bottom: 5px;margin-left: 8px;text-align: left;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247490044&amp;idx=1&amp;sn=f2b422d8a90c000ed0d3e3238b701359&amp;chksm=e8944371dfe3ca67590347ae8c52c8a7c03bd8483f84025c8d2e761dce4204f5fb3ad2c4b3d9&amp;scene=21#wechat_redirect\" data-itemshowtype=\"0\" tab=\"innerlink\" style=\"text-decoration: underline;\" data-linktype=\"2\" rel=\"noopener noreferrer\">Nature\uff1a\u5982\u4f55\u628a\u6570\u5343\u79cd\u5947\u5f02\u7684\u62d3\u6251\u6750\u6599\u4e00\u7f51\u6253\u5c3d<\/a><br  \/><\/p>\n<\/li>\n<li style=\"font-size: 14px;font-weight: bold;\">\n<p style=\"margin-right: 8px;margin-bottom: 5px;margin-left: 8px;text-align: left;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247489467&amp;idx=2&amp;sn=dfec148ca3b16df7c96e4c5dc75f8294&amp;chksm=e8944d36dfe3c420a2f16d7d5e378d7d6e506ebe8bf3a51de0a3e23d76473fdc9147281075fb&amp;scene=21#wechat_redirect\" data-itemshowtype=\"0\" tab=\"innerlink\" style=\"text-decoration: underline;\" data-linktype=\"2\" rel=\"noopener noreferrer\">Nature \u65b0\u8bc4\uff1a\u5229\u75283D\u56fe\u50cf\u63ed\u5bc6\u679c\u8747\u5927\u8111<\/a><br  \/><\/p>\n<\/li>\n<li style=\"font-size: 14px;font-weight: bold;\">\n<p style=\"margin-right: 8px;margin-bottom: 5px;margin-left: 8px;text-align: left;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247489408&amp;idx=1&amp;sn=5bf90fea3d75c3a306e53624e3e2ba12&amp;chksm=e8944d0ddfe3c41bd0b352a8b4d6248f9f1e911a09e12def4640689cdd4e24158196845da77c&amp;scene=21#wechat_redirect\" data-itemshowtype=\"0\" tab=\"innerlink\" style=\"text-decoration: underline;\" data-linktype=\"2\" rel=\"noopener noreferrer\">\u7528GCN\u56fe\u5377\u79ef\u7f51\u7edc\u9884\u6d4b\u6d77\u91cf\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u533b\u751f\u518d\u4e5f\u4e0d\u6015\u5f00\u9519\u836f\u4e86\uff01<\/a><br  \/><\/p>\n<\/li>\n<li style=\"font-weight: bold;font-size: 14px;\">\n<section powered-by=\"xiumi.us\" style=\"letter-spacing: 0.544px;\">\n<p style=\"margin-right: 8px;margin-bottom: 5px;margin-left: 8px;text-align: left;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247561270&amp;idx=1&amp;sn=e4d4454ba314931b5121332a0501280d&amp;chksm=e896aabbdfe123ad0014213b46a472704c4fd2f6c3a90f77b038353d12d41fc400474acbf193&amp;scene=21#wechat_redirect\" textvalue=\"\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);cursor: pointer;\" rel=\"noopener noreferrer\"><strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/a><\/p>\n<\/section>\n<p><br  \/><\/p>\n<p><br  \/><\/p>\n<\/li>\n<\/ul>\n<p><strong style=\"letter-spacing: 0.544px;text-align: left;font-size: 15px;color: rgb(255, 255, 255);font-family: PingFangSC-light;\"><span style=\"background-color: rgb(12, 130, 169);\"><strong style=\"letter-spacing: 0.544px;\">\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c<strong style=\"letter-spacing: 0.544px;\">\u8ffd\u8e2a\u590d\u6742\u79d1\u5b66\u9876\u520a\u8bba\u6587<\/strong><\/strong><\/span><\/strong><\/p>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5bfc\u8bed \u4e86\u89e3\u4e00\u4e2a\u751f\u7269\u8fc7\u7a0b\u6240\u9700\u7684\u5173\u952e\u4fe1\u606f\u4e4b\u4e00\u662f\u5176\u7ec4\u6210\u86cb\u767d\u7684\u7ed3\u6784\uff0c\u4f46\u7ed3\u6784\u6d4b\u5b9a\u7684\u5b9e\u9a8c\u65b9\u6cd5\u5f80\u5f80\u8017\u65f6\u8d39\u529b\uff0c\u800c\u4e14\u7ed3\u679c\u4e0d\u786e\u5b9a\uff0c\u9700\u8981\u6295\u5165\u5927\u91cf\u7684\u65f6\u95f4\u548c\u8d44\u6e90\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u86cb\u767d\u8d28\u5e8f\u5217\u5f88\u5bb9\u6613\u901a\u8fc7\u7ffb\u8bd1\u57fa\u56e0\u7ec4\u5e8f\u5217\u83b7\u5f97\uff0c\u5e76\u4e14\u53ef\u4ee5\u83b7\u5f97\u5927\u91cf\u7684\u86cb\u767d\u8d28\u3002\u7531\u4e8e\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u662f\u7531\u5176\u5e8f\u5217\u51b3\u5b9a\uff0c\u56e0\u6b64\u8bd5\u56fe\u4ece\u53e6\u4e00\u4e2a\u5e8f\u5217\u4e2d\u63a8\u5bfc\u51fa\u86cb\u767d\u8d28\u7684\u6298\u53e0\u95ee\u9898&#038;#8211&#8230;<\/p>\n","protected":false},"author":1,"featured_media":26538,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/26544"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26544"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/26544\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/26538"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26544"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26544"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26544"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=26544"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}