{"id":26974,"date":"2021-06-14T22:10:17","date_gmt":"2021-06-14T14:10:17","guid":{"rendered":"https:\/\/swarma.org\/?p=26974"},"modified":"2021-06-14T22:10:17","modified_gmt":"2021-06-14T14:10:17","slug":"%e5%9b%be%e5%8d%b7%e7%a7%af%e7%bd%91%e7%bb%9c%e9%9b%86%e6%88%90%e5%a4%9a%e7%bb%84%e5%ad%a6%e6%95%b0%e6%8d%ae%e5%88%86%e7%b1%bb%e6%96%b0%e7%ae%97%e6%b3%95-mogonet","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=26974","title":{"rendered":"\u56fe\u5377\u79ef\u7f51\u7edc\u96c6\u6210\u591a\u7ec4\u5b66\u6570\u636e\u5206\u7c7b\u65b0\u7b97\u6cd5\u2014\u2014MOGONET"},"content":{"rendered":"
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MOGONET integrates multi-omics data using graph convolutional networks allowing patient classification and biomarker identification<\/span><\/p>\n

\u8bba\u6587\u5730\u5740\uff1a<\/span><\/p>\n

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1. \u4e3a\u4f55\u8981\u4f7f\u7528\u591a\u7ec4\u5b66\u6570\u636e<\/strong><\/strong><\/p>\n<\/section>\n

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\u968f\u7740\u6df1\u5ea6\u5b66\u4e60\u5728\u5404\u79cd\u4efb\u52a1\u4e2d\u7684\u4e0d\u65ad\u63a8\u8fdb\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u591a\u7ec4\u5b66\u96c6\u6210\u65b9\u6cd5\u5f00\u59cb\u5229\u7528\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc\uff0c\u4f46\u73b0\u6709\u7684\u65b9\u6cd5\u90fd\u662f\u57fa\u4e8e\u5168\u8fde\u901a\u7f51\u7edc\u7684\uff0c\u6ca1\u6709\u901a\u8fc7\u76f8\u4f3c\u6027\u7f51\u7edc\u6709\u6548\u5730\u5229\u7528\u6837\u672c\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002\u6b64\u5916\uff0c\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u65b9\u6cd5\u5f80\u5f80\u5728\u8f93\u5165\u7a7a\u95f4\u6216\u5b66\u4e60\u7279\u5f81\u7a7a\u95f4\u96c6\u6210\u4e0d\u540c\u7684\u7ec4\u5b66\u6570\u636e\uff0c\u4f46\u4e0d\u540c\u7c7b\u578b\u7684\u7ec4\u5b66\u6570\u636e\u4e5f\u53ef\u5728\u62bd\u8c61\u7a0b\u5ea6\u8f83\u9ad8\u7684\u9690\u7a7a\u95f4\u4e2d\u5448\u73b0\u72ec\u7279\u7684\u7279\u5f81\u3002\u6545\u800c\u5229\u7528\u4e0d\u540c\u7ec4\u5b66\u6570\u636e\u7c7b\u578b\u4e4b\u95f4\u7684\u76f8\u5173\u6027\uff0c\u53ef\u8fdb\u4e00\u6b65\u63d0\u9ad8\u6a21\u578b\u6027\u80fd\u3002<\/span><\/section>\n


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2. MOGONET\u7684\u7f51\u7edc\u67b6\u6784<\/strong><\/strong><\/p>\n<\/section>\n

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MOGONET \u5728\u6807\u7b7e\u7a7a\u95f4<\/span>\uff08label space\uff09<\/span>\u5c06\u7ec4\u5b66\u7279\u5f02\u6027\u5b66\u4e60\u4e0e\u591a\u7ec4\u5b66\u96c6\u6210\u5206\u7c7b\u76f8\u7ed3\u5408\u3002\u5177\u4f53\u6765\u8bf4\uff0cMOGONET \u5148\u4f7f\u7528\u4f59\u5f26\u8ddd\u79bb\u6784\u5efa\u4e86\u6bcf\u79cd\u7ec4\u5b66\u6570\u636e\u7684\u52a0\u6743\u6837\u672c\u76f8\u4f3c\u6027\u7f51\u7edc\uff0c\u518d\u5229\u7528\u56fe\u5377\u79ef\u7f51\u7edc<\/span>\uff08GCN\uff09<\/span>\u8fdb\u884c\u5355\u4e2a\u7ec4\u5b66\u7684\u7279\u5f81\u521d\u59cb\u9884\u6d4b\uff0c\u4ee5\u53bb\u9664\u6570\u636e\u4e2d\u566a\u58f0\u548c\u5197\u4f59\u7279\u5f81\uff0c\u751f\u6210\u5bf9\u6240\u5c5e\u6807\u7b7e\u7684\u521d\u59cb\u9884\u6d4b\u3002\u6bcf\u4e2a\u7279\u5b9a\u4e8e\u7ec4\u5b66\u7684\u56fe\u5377\u79ef\u795e\u7ecf\u7f51\u7edc\u88ab\u8bad\u7ec3\u4f7f\u7528\u7ec4\u5b66\u7279\u5f81\u548c\u7531\u7ec4\u5b66\u6570\u636e\u751f\u6210\u7684\u76f8\u5e94\u6837\u672c\u7684\u76f8\u4f3c\u6027\u7f51\u7edc\u6765\u6267\u884c\u7c7b\u9884\u6d4b\u3002\u4e0e\u5168\u8fde\u901a\u7f51\u7edc\u76f8\u6bd4\uff0cGCN \u7b97\u6cd5\u5145\u5206\u5229\u7528\u4e86\u7ec4\u5b66\u7279\u5f81\u548c\u76f8\u4f3c\u7f51\u7edc\u63cf\u8ff0\u7684\u6837\u672c\u95f4\u7684\u76f8\u5173\u6027\uff0c\u4ece\u800c\u83b7\u5f97\u4e86\u66f4\u597d\u7684\u5206\u7c7b\u6027\u80fd\u3002<\/span><\/section>\n
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\u56fe1. MOGONET \u7684\u7f51\u7edc\u67b6\u6784<\/span><\/section>\n


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\u9664\u4e86\u76f4\u63a5\u8fde\u63a5\u6bcf\u4e2a\u7ec4\u5b66\u6570\u636e\u7c7b\u578b\u7684\u6807\u8bb0\u5206\u5e03\u5916\uff0cMOGONET\u53ef\u5229\u7528\u6bcf\u4e2a\u7ec4\u5b66\u7279\u5b9a GCN \u4ea7\u751f\u7684\u521d\u59cb\u9884\u6d4b\uff0c\u6784\u9020\u53cd\u6620\u7ec4\u5b66\u6807\u8bb0\u76f8\u5173\u6027\u7684\u4ea4\u53c9\u7ec4\u5b66\u53d1\u73b0\u5f20\u91cf\u3002VCDN \u901a\u8fc7\u5728\u9ad8\u5c42\u6807\u7b7e\u7a7a\u95f4\u4e2d\u63a2\u7d22\u4e0d\u540c\u7ec4\u5b66\u6570\u636e\u7c7b\u578b\u4e4b\u95f4\u7684\u6f5c\u5728\u76f8\u5173\u6027\uff0c\u53ef\u4ee5\u6709\u6548\u5730\u6574\u5408\u6765\u81ea\u6bcf\u4e2a\u7ec4\u5b66\u7279\u5b9a\u7f51\u7edc\u7684\u521d\u59cb\u9884\u6d4b\uff0c\u5b9e\u73b0\u6709\u6548\u7684\u591a\u7ec4\u5b66\u96c6\u6210\u3002MOGONET \u662f\u7b2c\u4e00\u4e2a\u5229\u7528 GCNs \u8fdb\u884c\u7ec4\u5b66\u6570\u636e\u5b66\u4e60\u7684\u6709\u76d1\u7763\u7684\u591a\u7ec4\u5b66\u7efc\u5408\u65b9\u6cd5\u3002MOGONET \u4f5c\u4e3a\u4e00\u4e2a\u7aef\u5230\u7aef\u7684\u6a21\u578b\uff0c\u6240\u6709\u7684\u7f51\u7edc\u90fd\u53ef\u8054\u5408\u8bad\u7ec3\u7684\u3002\u5176\u7f51\u7edc\u67b6\u6784\u5982\u4e0b\uff1a<\/span><\/section>\n


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3. MOGONET\u7684\u9884\u6d4b\u51c6\u786e\uff0c<\/strong><\/strong><\/p>\n

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       <\/span>\u56fe2. \u4f7f\u7528MOGONET\uff0c\u57fa\u4e8e\u5355\u4e2a\u6216\u591a\u4e2a\u7ec4\u5b66\uff0c\u5728\u4e09\u79cd\u4e0d\u540c\u6570\u636e\u96c6ROSMAP\uff08\u963f\u5179\u6d77\u9ed8\uff09LGG \uff08\u795e\u7ecf\u80f6\u8d28\u7624\uff09\u548c BRAC\uff08\u4e73\u817a\u764c\uff09\u4e0a\u7684\u5206\u7c7b\u8868\u73b0<\/span><\/section>\n


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       <\/span>\u56fe3. \u8d85\u53c2\u6570K\u7684\u4e0d\u540c\u53d6\u503c\u4e0b\u5206\u7c7b\u6548\u679c\u7684\u6298\u7ebf\u56fe<\/span><\/span><\/section>\n


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\u597d\u7684\u5206\u7c7b\u65b9\u6cd5\uff0c\u5bf9\u4e8e\u8d85\u53c2\u6570\u53d6\u503c\u6539\u53d8\u65f6\uff0c\u6027\u80fd\u4e0d\u4f1a\u663e\u8457\u5bf9\u6bd4\uff0c\u4e0a\u56fe\u5206\u5e03\u5bf9\u6bd4\u4e86\u5728LGG\u548cBRAC\u6570\u636e\u96c6\u4e0a\uff0c\u5f53MOGONET\u4e2d\u6700\u91cd\u8981\u7684\u8d85\u53c2\u6570K\u4ece2\u53d8\u4e3a10\u65f6\uff0cMOGONET\u8868\u73b0\u76f8\u5bf9\u7a33\u5b9a\uff0c\u4e14\u59cb\u7ec8\u4f18\u4e8e\u5176\u5b83\u65b9\u6cd5\u3002<\/span><\/section>\n


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\u9664\u6b64\u4e4b\u5916\uff0cMOGONET\u7684\u53e6\u4e00\u7279\u6027\u662f\u5176\u80fd\u591f\u4ece\u591a\u7ec4\u5b66\u6570\u636e\u7684\u4f17\u591a\u7279\u5f81\u4e2d\uff0c\u7cbe\u51c6\u5730\u627e\u51fa\u90a3\u4e9b\u80fd\u591f\u8ba9\u4e0d\u540c\u6807\u7b7e\u7684\u6570\u636e\u533a\u5206\u51fa\u6765\u7684\u7279\u5f81\uff0c\u8fd9\u88ab\u79f0\u4e3a\u751f\u7269\u6807\u5fd7\u7269\u3002\u4f8b\u5982\u5728\u963f\u5179\u6d77\u9ed8\u75c7\u7684\u6570\u636e\u96c6\u4e2d\uff0c\u53ef\u4ee5\u627e\u51fa\u90a3\u4e9b\u57fa\u56e0\u7684\u6539\u53d8\uff0c\u4f1a\u5bfc\u81f4\u963f\u5179\u6d77\u9ed8\u75c7\u7684\u53d1\u751f\uff0c\u4ece\u800c\u4e3a\u836f\u7269\u7814\u53d1\uff0c\u75be\u75c5\u65e9\u7b5b\u63d0\u4f9b\u77e5\u8bc6\u4f9d\u636e\u3002<\/span><\/section>\n

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\u590d\u6742\u79d1\u5b66\u6700\u65b0\u8bba\u6587<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u96c6\u667a\u6591\u56fe\u9876\u520a\u8bba\u6587\u901f\u9012\u680f\u76ee\u4e0a\u7ebf\u4ee5\u6765\uff0c\u6301\u7eed\u6536\u5f55\u6765\u81eaNature\u3001Science<\/span>\u7b49\u9876\u520a\u7684\u6700\u65b0\u8bba\u6587\uff0c\u8ffd\u8e2a\u590d\u6742\u7cfb\u7edf\u3001\u7f51\u7edc\u79d1\u5b66\u3001\u8ba1\u7b97\u793e\u4f1a\u79d1\u5b66\u7b49\u9886\u57df\u7684\u524d\u6cbf\u8fdb\u5c55\u3002\u73b0\u5728\u6b63\u5f0f\u63a8\u51fa\u8ba2\u9605\u529f\u80fd\uff0c\u6bcf\u5468\u901a\u8fc7\u5fae\u4fe1\u670d\u52a1\u53f7\u300c\u96c6\u667a\u6591\u56fe\u300d\u63a8\u9001\u8bba\u6587\u4fe1\u606f\u3002\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\u5373\u53ef\u4e00\u952e\u8ba2\u9605\uff1a<\/span>
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\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n