{"id":29257,"date":"2021-10-09T22:18:37","date_gmt":"2021-10-09T14:18:37","guid":{"rendered":"https:\/\/swarma.org\/?p=29257"},"modified":"2021-10-09T22:18:37","modified_gmt":"2021-10-09T14:18:37","slug":"%e6%98%8e%e6%99%9a%e5%85%ab%e7%82%b9-%e6%88%91%e4%bb%ac%e5%a6%82%e4%bd%95%e6%84%9f%e5%8f%97%e4%b8%96%e7%95%8c%ef%bc%9f%e8%bf%bd%e9%97%ae2021%e8%af%ba%e8%b4%9d%e5%b0%94%e7%94%9f%e7%90%86%e5%ad%a6","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=29257","title":{"rendered":"\u660e\u665a\u516b\u70b9 | \u6211\u4eec\u5982\u4f55\u611f\u53d7\u4e16\u754c\uff1f\u8ffd\u95ee2021\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956"},"content":{"rendered":"<div class='wxsyncmain'>\n<section data-mpa-powered-by=\"yiban.io\">\n<section style=\"margin: 20px 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"color: rgb(153, 153, 153);line-height: 1.8;letter-spacing: 1px;padding-right: 20px;padding-left: 20px;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;margin-left: 0px;margin-right: 0px;\"><span style=\"color: rgb(74, 74, 74);box-sizing: border-box;font-size: 15px;\">\u5317\u4eac\u65f6\u95f42021\u5e7410\u67084\u65e5\uff0c2021\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u6b63\u5f0f\u9881\u5e03\uff0c\u83b7\u5f97\u8005\u4e3aDavid Julius\u6559\u6388\u548cArdem Patapoutian\u6559\u6388\uff0c\u4ee5\u8868\u5f70\u4ed6\u4eec\u5728\u201c\u6e29\u5ea6\u548c\u89e6\u89c9\u611f\u53d7\u5668\u201d\u4e0a\u505a\u51fa\u7684\u5353\u8d8a\u8d21\u732e\u3002<\/span><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 96%;height: auto;box-sizing: border-box;\"><img data-ratio=\"0.8148148\"  data-type=\"png\" data-w=\"1080\" 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style=\"box-sizing: border-box;\"  \/><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><strong style=\"box-sizing: border-box;\"><span style=\"font-size: 15px;box-sizing: border-box;\">\u6211\u4eec\u5982\u4f55\u611f\u53d7\u5230\u6c14\u6e29\u7684\u53d8\u5316\u6765\u6dfb\u8863\u51cf\u8863?<\/span><\/strong><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><strong style=\"box-sizing: border-box;\"><span style=\"font-size: 15px;box-sizing: border-box;\">\u6211\u4eec\u5982\u4f55\u6e29\u67d4\u5730\u629a\u6478\u8db4\u5728\u817f\u4e0a\u7684\u732b\u54aa\uff1f<\/span><\/strong><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><strong style=\"box-sizing: 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Patapoutian\u6559\u6388\u7684\u7814\u7a76\uff0c\u4f7f\u5f97\u6211\u4eec\u53ef\u4ee5\u63ed\u5f00\u73af\u5883\u611f\u53d7\u548c\u5927\u8111\u795e\u7ecf\u51b2\u52a8\u4e4b\u95f4\u7684\u8054\u7cfb\uff0c\u5e76\u4e3a\u6211\u4eec\u63a2\u7d22\u672a\u6765\u66f4\u591a\u7684\u7597\u6cd5\u63d0\u4f9b\u4e86\u53ef\u80fd\u6027\u3002<\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><strong style=\"box-sizing: border-box;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);box-sizing: border-box;\">\u4e3a\u6b64\uff0c\u5929\u6865\u8111\u79d1\u5b66\u7814\u7a76\u9662\uff08TCCI\uff09\u5c06\u5f00\u542f\u8ffd\u95ee\u7814\u8ba8\u4f1a\u76f4\u64ad\u6d3b\u52a8\u2014\u2014\u8ffd\u95ee2021\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u3002<\/span><\/strong><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: 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70.4181%;background-repeat: no-repeat;background-size: 100%;border-width: 5px;box-shadow: rgba(249, 155, 153, 0.92) 0.7px 0.7px 2px;border-color: rgb(255, 255, 255);border-radius: 100%;border-style: solid;background-image: url('\/wp-content\/uploads\/2021\/10\/wxsync-2021-10-1b7f7f9bc7a486e66b53abfccf042478.jpeg');\">\n<section style=\"height: 100%;overflow: hidden;line-height: 0;vertical-align: middle;max-width: 100%;box-sizing: border-box;\"><img data-ratio=\"1.3361111\"  data-type=\"jpeg\" data-w=\"1080\" style=\"width: 100%;height: 100%;opacity: 0;box-sizing: border-box;\" src=\"\/wp-content\/uploads\/2021\/10\/wxsync-2021-10-b7ff89b1ff939fa9e8f0aad804797441.jpeg\"  \/><\/section>\n<\/section>\n<section style=\"border-color: rgb(249, 110, 87);background-color: rgba(241, 248, 255, 0.6);padding: 10px;margin-right: 3.5em;border-style: none;border-width: 2px;border-radius: 4px;box-shadow: rgb(0, 0, 0) 0px 0px 0px;letter-spacing: 0px;box-sizing: border-box;\">\n<section 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style=\"display: inline-block;vertical-align: middle;padding-right: 5px;padding-left: 5px;font-size: 18px;color: rgb(118, 118, 118);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5609\u5bbe<\/strong><\/p>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;box-sizing: border-box;\">\n<section style=\"width: 0px;transform: rotate(0deg);-webkit-transform: rotate(0deg);-moz-transform: rotate(0deg);-o-transform: rotate(0deg);margin-bottom: -5px;border-left: 0.56em solid rgb(110, 125, 118);border-top: 0.31em solid transparent;border-bottom: 0.31em solid transparent;box-sizing: border-box;\">\n<section><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<section style=\"width: 0px;border-left: 0.56em solid rgb(249, 155, 153);border-top: 0.31em solid transparent;border-bottom: 0.31em solid transparent;box-sizing: border-box;\">\n<section><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;font-size: 12px;color: rgb(160, 160, 160);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"box-sizing: border-box;\">*\u4ee5\u59d3\u540d\u9996\u5b57\u6bcd\u6392\u5e8f<\/p>\n<\/section>\n<section style=\"margin: 10px 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"box-sizing: border-box;width: 7em;height: 7em;display: inline-block;vertical-align: bottom;border-radius: 100%;border-width: 5px;border-style: solid;float: right;margin-left: 5px;box-shadow: rgba(249, 155, 153, 0.92) 0.7px 0.7px 2px;border-color: rgb(255, 255, 255);background-position: center center;background-repeat: no-repeat;background-size: cover;overflow: hidden;background-image: 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18px;letter-spacing: 0px;box-sizing: border-box;\">\u9ad8&nbsp; \u6e90<\/strong><\/p>\n<\/section>\n<section style=\"font-size: 12px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\">\u54c8\u4f5b\u533b\u5b66\u9662\/\u970d\u534e\u5fb7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240\u535a\u58eb\u540e\u7814\u7a76\u5458<\/p>\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: left;font-size: 14px;box-sizing: border-box;\">\n<p style=\"text-align: justify;clear: none;white-space: normal;box-sizing: border-box;\">\u9ad8\u6e90\u535a\u58eb\u53d7Damon Runyon\u764c\u75c7\u7814\u7a76\u57fa\u91d1\u4f1a\u8d44\u52a9\uff0c\u73b0\u5728Tom 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normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<section style=\"margin: 10px 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"box-sizing: border-box;width: 7em;height: 7em;display: inline-block;vertical-align: bottom;border-radius: 100%;border-width: 5px;border-style: solid;float: right;margin-left: 5px;box-shadow: rgba(249, 155, 153, 0.92) 0.7px 0.7px 2px;border-color: rgb(255, 255, 255);background-position: 0% 26.4129%;background-repeat: no-repeat;background-size: 100%;overflow: hidden;background-image: url('\/wp-content\/uploads\/2021\/10\/wxsync-2021-10-1b7f7f9bc7a486e66b53abfccf042478.jpeg');\">\n<section style=\"height: 100%;overflow: hidden;line-height: 0;vertical-align: middle;max-width: 100%;box-sizing: border-box;\"><img data-ratio=\"1.4987775\"  data-type=\"jpeg\" data-w=\"409\" style=\"width: 100%;height: 100%;opacity: 0;box-sizing: border-box;\" 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border-box;\">\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u6559\u6388\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\u3002\u7f8e\u56fd\u83b1\u65af\u5927\u5b66\u751f\u7269\u5316\u5b66\u535a\u58eb\uff0c\u66fe\u5728\u7f8e\u56fd\u6d1b\u514b\u83f2\u52d2\u5927\u5b66\u4ece\u4e8b\u535a\u58eb\u540e\u7814\u7a76\u3002<\/p>\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 14px;box-sizing: border-box;\">\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\">\u90ed\u96e8\u677e\u6559\u6388\u5e08\u4ece\u4ee5\u94be\u79bb\u5b50\u901a\u9053\u7684\u7ed3\u6784\u548c\u529f\u80fd\u7814\u7a76\u83b7\u5f972003\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u7684Roderick 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solid;float: right;margin-left: 5px;box-shadow: rgba(249, 155, 153, 0.92) 0.7px 0.7px 2px;border-color: rgb(255, 255, 255);background-position: 43.0693% 32.8947%;background-repeat: no-repeat;background-size: 166.013%;overflow: hidden;background-image: url('\/wp-content\/uploads\/2021\/10\/wxsync-2021-10-1b7f7f9bc7a486e66b53abfccf042478.jpeg');\">\n<section style=\"height: 100%;overflow: hidden;line-height: 0;vertical-align: middle;max-width: 100%;box-sizing: border-box;\"><img data-ratio=\"1.5\"  data-type=\"jpeg\" data-w=\"1026\" style=\"width: 100%;height: 100%;opacity: 0;box-sizing: border-box;\" src=\"\/wp-content\/uploads\/2021\/10\/wxsync-2021-10-098f38d968059b6321a5d84c8171aed8.jpeg\"  \/><\/section>\n<\/section>\n<section style=\"border-color: rgb(249, 110, 87);background-color: rgba(241, 248, 255, 0.6);padding: 10px;margin-right: 3.5em;border-style: none;border-width: 2px;border-radius: 4px;box-shadow: rgb(0, 0, 0) 0px 0px 0px;letter-spacing: 0px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 18px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u6768&nbsp; \u5dcd<\/strong><\/span><\/p>\n<\/section>\n<section style=\"font-size: 12px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\">\u6d59\u6c5f\u5927\u5b66\u57fa\u7840\u533b\u5b66\u9662\u526f\u9662\u957f\uff0c\u6559\u6388\uff0c\u535a\u5bfc\uff0c\u6d59\u6c5f\u7701\u6770\u51fa\u9752\u5e74\u57fa\u91d1\u83b7\u5f97\u8005\u3002<\/p>\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 14px;box-sizing: border-box;\">\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\">\u6768\u5dcd\u6559\u6388\u957f\u671f\u4ece\u4e8b\u7814\u7a76\u79bb\u5b50\u901a\u9053\uff08TRPM2\u901a\u9053\uff0cNMDA\u53d7\u4f53\u548cTRPV1\u7b49\uff09\u95e8\u63a7\u8c03\u8282\u673a\u5236\u53ca\u5176\u4ecb\u5bfc\u751f\u7406\u75c5\u7406\u529f\u80fd\uff0c\u5e76\u9488\u5bf9\u8fd9\u4e9b\u9776\u70b9\u5f00\u53d1\u8111\u4e2d\u98ce\u7b49\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u6cbb\u7597\u836f\u7269\u3002\u4ee5\u901a\u8baf\u4f5c\u8005\u8eab\u4efd\u5728\u5305\u62ecCell Research\u3001Nature Communications\u3001Cell Reports\u3001Particle and Fibre Toxicology\u3001Antioxidant Redox Signaling\u3001 J. Biol. Chem.\u3001J. Gen. Physiol\u7b49\u56fd\u9645\u77e5\u540d\u6742\u5fd7\u4e0a\u53d1\u8868\u5b66\u672f\u8bba\u658740\u591a\u7bc7\uff0c\u88ab\u6743\u5a01\u671f\u520aNature\u3001Science\u3001Nature Review Science\u3001Pharmological Review\u7b49\u6b63\u9762\u5f15\u7528\u3002\u8fd1\u5e74\u4e3b\u6301\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u91cd\u70b9\u9879\u76ee\u53ca\u9762\u4e0a\u9879\u76ee\uff0c\u79d1\u6280\u90e8\u86cb\u767d\u8d28\u91cd\u5927\u7814\u7a76\u8ba1\u5212\u5b50\u8bfe\u9898\uff0c\u56fd\u5bb6\u91cd\u5927\u65b0\u836f\u4e13\u9879\u5b50\u8bfe\u9898\u591a\u9879\u79d1\u7814\u9879\u76ee\u3002\u66fe\u83b7\u5f97\u4e2d\u56fd\u795e\u7ecf\u5b66\u4f1a\u9752\u5e74\u5b66\u672f\u8bba\u575b\u4e00\u7b49\u5956\uff0c\u82f1\u56fd\u7687\u5bb6\u5b66\u4f1a\u725b\u987f\u56fd\u9645\u5956\u5b66\u91d1\uff0c\u4e2d\u56fd\u751f\u7406\u5b66\u4f1a\u5f20\u9521\u94a7\u57fa\u91d1\u4f18\u79c0\u9752\u5e74\u8bba\u6587\u4e00\u7b49\u5956\u7b49\u30022016\u5e74\u5165\u9009\u6d59\u6c5f\u7701\u4f18\u79c0\u79d1\u6280\u5de5\u4f5c\u8005\u548c\u6d59\u6c5f\u7701151\u7b2c\u4e8c\u5c42\u6b21\u4eba\u624d\uff0c2020\u5e74\u5165\u9009\u6d59\u6c5f\u7701\u536b\u751f\u9ad8\u5c42\u6b21\u521b\u65b0\u4eba\u624d\u3002\u76ee\u524d\u62c5\u4efb\u4e2d\u56fd\u751f\u7406\u5b66\u4f1a\u5e38\u52a1\u7406\u4e8b\uff0c\u4e2d\u56fd\u795e\u7ecf\u79d1\u5b66\u5b66\u4f1a\u7406\u4e8b\u517c\u79bb\u5b50\u901a\u9053\u4e0e\u53d7\u4f53\u5206\u4f1a\u4f1a\u957f\uff0c\u6d59\u6c5f\u7701\u795e\u7ecf\u79d1\u5b66\u5b66\u4f1a\u79d8\u4e66\u957f\u7b49\u5b66\u672f\u517c\u804c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<section style=\"margin: 10px 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"box-sizing: border-box;width: 7em;height: 7em;display: inline-block;vertical-align: bottom;border-radius: 100%;border-width: 5px;border-style: solid;float: right;margin-left: 5px;box-shadow: rgba(249, 155, 153, 0.92) 0.7px 0.7px 2px;border-color: rgb(255, 255, 255);background-position: center center;background-repeat: no-repeat;background-size: cover;overflow: hidden;background-image: url('\/wp-content\/uploads\/2021\/10\/wxsync-2021-10-1b7f7f9bc7a486e66b53abfccf042478.jpeg');\">\n<section style=\"height: 100%;overflow: hidden;line-height: 0;vertical-align: middle;max-width: 100%;box-sizing: border-box;\"><img data-ratio=\"1.2722772\"  data-type=\"jpeg\" data-w=\"404\" style=\"width: 100%;height: 100%;opacity: 0;box-sizing: border-box;\" src=\"\/wp-content\/uploads\/2021\/10\/wxsync-2021-10-1b7f7f9bc7a486e66b53abfccf042478.jpeg\"  \/><\/section>\n<\/section>\n<section style=\"border-color: rgb(249, 110, 87);background-color: rgba(241, 248, 255, 0.6);padding: 10px;margin-right: 3.5em;border-style: none;border-width: 2px;border-radius: 4px;box-shadow: rgb(0, 0, 0) 0px 0px 0px;letter-spacing: 0px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 18px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u59da&nbsp; \u955c<\/strong><\/span><\/p>\n<\/section>\n<section style=\"font-size: 12px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\">\u6b66\u6c49\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\u7ec6\u80de\u751f\u7269\u5b66\u7cfb\u6559\u6388\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\uff0c\u75c5\u6bd2\u5b66\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u548c\u7ec6\u80de\u7a33\u6001\u6e56\u5317\u7701\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u56fa\u5b9aPI\uff0c\u6559\u80b2\u90e8\u514d\u75ab\u4e0e\u4ee3\u8c22\u524d\u6cbf\u79d1\u5b66\u4e2d\u5fc3\u517c\u804cPI\uff0c\u6e56\u5317\u7701\u695a\u5929\u5b66\u8005\u7279\u8058\u6559\u6388\uff0c\u6e56\u5317\u7701\u6770\u51fa\u9752\u5e74\u57fa\u91d1\u83b7\u5f97\u8005\u3002<\/p>\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 14px;box-sizing: border-box;\">\n<p style=\"clear: none;white-space: normal;box-sizing: border-box;\">\u59da\u955c\u6559\u6388\u957f\u671f\u4ece\u4e8b\u79bb\u5b50\u901a\u9053\u7684\u751f\u7406\u4e0e\u751f\u7269\u7269\u7406\u5b66\u7814\u7a76\uff0c\u91cd\u70b9\u5173\u6ce8\u4e0e\u75db\u89c9\u53ca\u4f24\u5bb3\u6027\u4f20\u5bfc\u5bc6\u5207\u76f8\u5173\u7684\u77ac\u65f6\u53d7\u4f53\u52bf\u901a\u9053\uff08TRP channels\uff09\u7684\u751f\u7269\u5b66\u529f\u80fd\u548c\u4f5c\u7528\u673a\u5236\uff0c\u805a\u7126\u4e8eTRP\u901a\u9053\u7684\u95e8\u63a7\uff08\u5f00\u542f\u6216\u5173\u95ed\uff09\u673a\u5236\u4e0e\u529f\u80fd\u8c03\u63a7\uff0c\u4ee5\u9610\u8ff0TRP\u901a\u9053\u5728\u795e\u7ecf\u4fe1\u53f7\u8c03\u63a7\u53ca\u6297\u75c5\u6bd2\u611f\u67d3\u514d\u75ab\u53cd\u5e94\u4e2d\u7684\u4f5c\u7528\u4e3a\u4e3b\u8981\u7814\u7a76\u76ee\u6807\uff0c\u8fc4\u4eca\uff0c\u5df2\u53d1\u8868\u76f8\u5173\u7814\u7a76\u8bba\u658736\u7bc7\uff0c\u5176\u4e2d\u4f5c\u4e3a\u7b2c\u4e00\u4f5c\u8005\u6216\u901a\u8baf\u4f5c\u8005\u5728PNAS\u3001ELife\u3001Nat. Commun\u3001Plos Biology\u548cAm. J. Hum. Genet.\u7b49\u77e5\u540d\u4e13\u4e1a\u671f\u520a\u4e0a\u5171\u53d1\u8868\u4e8623\u7bc7\u8bba\u6587\u3002\u90e8\u5206\u6210\u679c\u8fd8\u88abPNAS\u3001Am. J. Hum. Genet.\u3001Plos Biol.\u4ee5\u53caFaculty of 1000\u7b49\u4f5c\u4e3a\u70ed\u70b9\u8bba\u6587\u63a8\u8350\uff0c\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u88ab\u56fd\u5185\u5916\u540c\u884c\u5728Cell\u3001Nature\u548cNeuron\u7b49\u77e5\u540d\u671f\u520a\u4e0a\u6b63\u9762\u5f15\u7528\u6216\u8bc4\u8ff0\uff0c\u5f97\u5230\u4e86\u5e7f\u6cdb\u7684\u5173\u6ce8\u3002\u4e3b\u6301\u5404\u7c7b\u79d1\u7814\u9879\u76ee\u591a\u9879\uff0c\u76ee\u524d\u5206\u522b\u4e3a\u4e2d\u56fd\u751f\u7269\u7269\u7406\u5b66\u4f1a\u201c\u819c\u751f\u7269\u7269\u7406\u4e13\u4e1a\u59d4\u5458\u4f1a\u201d\u548c\u201c\u795e\u7ecf\u751f\u7269\u7269\u7406\u4e13\u4e1a\u59d4\u5458\u4f1a\u201d\u7684\u59d4\u5458\uff0c\u4e2d\u56fd\u795e\u7ecf\u79d1\u5b66\u5b66\u4f1a\u201c\u79bb\u5b50\u901a\u9053\u4e0e\u53d7\u4f53\u4e13\u4e1a\u59d4\u5458\u4f1a\u201d\u59d4\u5458\uff0c\u4e2d\u56fd\u836f\u7406\u5b66\u4f1a\u201c\u795e\u7ecf\u7cbe\u795e\u836f\u7406\u4e13\u4e1a\u59d4\u5458\u4f1a\u201d\u9752\u5e74\u59d4\u5458\u4ee5\u53ca\u6e56\u5317\u7701\u7ec6\u80de\u751f\u7269\u5b66\u4f1a\u548c\u6e56\u5317\u7701\u751f\u7269\u7269\u7406\u5b66\u4f1a\u7684\u7406\u4e8b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;background-color: rgb(241, 248, 255);box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: flex;flex-flow: row nowrap;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: auto;flex: 0 0 0%;height: auto;line-height: 0;align-self: flex-start;border-width: 0px;margin-top: 5px;margin-left: 7px;box-sizing: border-box;\">\n<section style=\"text-align: center;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 2px;height: 10px;vertical-align: top;overflow: 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inline-block;width: 12px;height: 12px;vertical-align: top;overflow: hidden;border-width: 2px;border-radius: 47px;border-style: solid;border-color: rgb(204, 95, 92);box-sizing: border-box;\">\n<section><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 15px;line-height: 1.6;letter-spacing: 4px;padding-right: 32px;padding-left: 32px;box-sizing: border-box;\">\n<p style=\"text-align: left;white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><span style=\"color: rgb(255, 255, 255);text-shadow: rgb(35, 35, 35) 1px 1px, rgb(35, 35, 35) 1px -1px, rgb(35, 35, 35) -1px 1px, rgb(35, 35, 35) -1px -1px, rgb(35, 35, 35) 0px 1.4px, rgb(35, 35, 35) 0px -1.4px, rgb(35, 35, 35) -1.4px 0px, rgb(35, 35, 35) 1.4px 0px, 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flex-start;box-sizing: border-box;\">\n<section style=\"text-align: center;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 3px;height: 15px;vertical-align: top;overflow: hidden;background-color: rgb(204, 95, 92);box-sizing: border-box;\">\n<section><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;justify-content: center;margin: -9px 0% 7px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 15px;height: 3px;vertical-align: top;overflow: hidden;background-color: rgb(204, 95, 92);box-sizing: border-box;\">\n<section><svg viewbox=\"0 0 1 1\" style=\"float:left;line-height:0;width:0;vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-right: 0%;margin-left: 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;border-style: solid;border-width: 6px;border-color: rgb(241, 248, 255);box-sizing: border-box;\">\n<section style=\"margin: 20px 0%;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"font-size: 14px;letter-spacing: 1px;line-height: 1.8;padding-right: 25px;padding-left: 25px;color: rgb(74, 74, 74);box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5929\u6865\u8111\u79d1\u5b66\u7814\u7a76\u9662\uff08Tianqiao and Chrissy Chen 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