{"id":29489,"date":"2021-10-25T23:03:17","date_gmt":"2021-10-25T15:03:17","guid":{"rendered":"https:\/\/swarma.org\/?p=29489"},"modified":"2021-10-25T23:03:17","modified_gmt":"2021-10-25T15:03:17","slug":"pnas%e5%89%8d%e6%b2%bf%ef%bc%9a%e8%87%aa%e5%82%ac%e5%8c%96%e7%bd%91%e7%bb%9c%e5%a6%82%e4%bd%95%e4%bf%83%e8%bf%9b%e7%bb%86%e8%8f%8c%e7%94%9f%e9%95%bf%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=29489","title":{"rendered":"PNAS\u524d\u6cbf\uff1a\u81ea\u50ac\u5316\u7f51\u7edc\u5982\u4f55\u4fc3\u8fdb\u7ec6\u83cc\u751f\u957f\uff1f"},"content":{"rendered":"
\n
\n
\n
\n

<\/p>\n<\/section>\n

\n
\n
\n
\n
\n
\n

<\/section>\n<\/section>\n
\n
\n

\u5bfc\u8bed<\/strong><\/p>\n<\/section>\n<\/section>\n

\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

<\/strong>\u8f6c\u5f55-\u7ffb\u8bd1\u673a\u5668\u662f\u7ec6\u80de\u81ea\u590d\u5236\u7684\u6838\u5fc3\u3002\u7ec6\u83cc\u751f\u957f\u9075\u5faa\u7b80\u5355\u7684\u6570\u5b66\u89c4\u5f8b\uff0c\u8fd9\u662f\u5426\u53ef\u4ee5\u901a\u8fc7\u8f6c\u5f55\u3001\u7ffb\u8bd1\u8fd9\u4e9b\u5e95\u5c42\u751f\u5316\u8fc7\u7a0b\u6765\u89e3\u91ca\uff1f2021\u5e747\u6708\u53d1\u8868\u4e8e PNAS \u7684\u8bba\u6587\u201c\u4e00\u4e2a\u7edf\u4e00\u7684\u57fa\u4e8e\u81ea\u50ac\u5316\u7f51\u7edc\u7684\u7ec6\u83cc\u751f\u957f\u89c4\u5f8b\u6846\u67b6\u201d\u6784\u5efa\u4e86\u7ec6\u83cc\u7684\u81ea\u50ac\u5316\u7f51\u7edc\u6846\u67b6\uff0c\u5e76\u63a8\u5bfc\u8bf4\u660e\uff0c\u6838\u7cd6\u4f53\u5faa\u73af\u3001RNA\u805a\u5408\u9176\u5faa\u73af\u7b49\u8fc7\u7a0b\u4e4b\u95f4\u7684\u8026\u5408\u4fc3\u8fdb\u4e86\u7ec6\u83cc\u7684\u5747\u8861\u6307\u6570\u7ea7\u589e\u957f\u3002\u4e0d\u8fc7\uff0c\u901a\u8fc7\u7b80\u5355\u7684\u6570\u5b66\u5173\u7cfb\u6765\u63cf\u8ff0\u7ec6\u83cc\u751f\u7406\u8fc7\u7a0b\u662f\u201c\u7269\u7406\u7684\u201d\uff1b\u800c\u8fd9\u80cc\u540e\u5404\u4e2a\u751f\u7406\u673a\u5236\u4e4b\u95f4\u7684\u590d\u6742\u5173\u7cfb\u5219\u662f\u201c\u751f\u7269\u7684\u201d\uff0c\u7406\u89e3\u751f\u5316\u8fc7\u7a0b\u4e0e\u751f\u957f\u901f\u7387\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u5e76\u4e0d\u5bb9\u6613\uff0c\u9700\u8981\u5bf9\u7ec6\u83cc\u7ec6\u80de\u5185\u7684\u81ea\u50ac\u5316\u7f51\u7edc\u6709\u66f4\u5168\u5c40\u7684\u7406\u89e3\u3002<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u9886\u57df\uff1a\u7ec6\u83cc\u751f\u957f\u89c4\u5f8b\u3001\u81ea\u50ac\u5316\u5faa\u73af\u3001\u81ea\u590d\u5236\u3001\u8f6c\u5f55-\u7ffb\u8bd1\u673a\u5668<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
<\/strong><\/section>\n<\/section>\n
\n

\u5218\u6842<\/span> | \u4f5c\u8005<\/strong><\/span><\/strong><\/p>\n

\u6881\u91d1 <\/span>| \u5ba1\u6821<\/strong><\/span><\/strong><\/span><\/p>\n

\u9093\u4e00\u96ea<\/span> | \u7f16\u8f91<\/strong><\/span>
<\/p>\n<\/section>\n


<\/section>\n

<\/section>\n
<\/section>\n
\n
\n
\n

\u8bba\u6587\u9898\u76ee\uff1a<\/span><\/p>\n

<\/span>A unifying autocatalytic network-based framework for bacterial growth laws<\/span>
<\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1a<\/span><\/p>\n

<\/span>https:\/\/www.pnas.org\/content\/118\/33\/e2107829118<\/span><\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n

<\/span><\/section>\n


<\/p>\n

\u7814\u7a76\u53d1\u73b0\uff0c\u7ec6\u83cc\u751f\u957f\u7684\u60c5\u51b5\u53ef\u4ee5\u7528\u7b80\u5355\u7684\u6570\u5b66\u5173\u7cfb\u6765\u63cf\u8ff0\uff0c\u5373\u7ec6\u83cc\u751f\u957f\u89c4\u5f8b\u3002\u8fd9\u8bf4\u660e\uff0c\u7ec6\u83cc\u751f\u957f\u7684\u6838\u5fc3\u53ef\u80fd\u5b58\u5728\u7740\u7b80\u5355\u7684\u57fa\u672c\u539f\u7406\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u7ec6\u83cc\u7684\u7ec6\u80de\u5305\u542b\u5404\u5f0f\u5404\u6837\u7684\u81ea\u50ac\u5316\u7f51\u7edc\uff0c\u4ee5\u6838\u7cd6\u4f53\u5faa\u73af\u4e3a\u4f8b\uff1a\u6838\u7cd6\u4f53\u80fd\u591f\u7ffb\u8bd1\u51fa\u7ec4\u6210\u6838\u7cd6\u4f53\u7684\u86cb\u767d\uff0c\u800c\u540e\u8005\u901a\u8fc7\u81ea\u7ec4\u88c5\u5f62\u6210\u65b0\u7684\u6838\u7cd6\u4f53\u3002\u603b\u4f53\u6765\u8bf4\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\u6838\u7cd6\u4f53\u5e76\u6ca1\u6709\u88ab\u6d88\u8017\uff0c\u53cd\u800c\u6210\u4e3a\u4e86\u81ea\u50ac\u5316\u5faa\u73af\u7684\u6838\u5fc3\u50ac\u5316\u5242\u3002<\/span><\/p>\n


<\/p>\n

\u5728\u8fd9\u7bc7\u6587\u7ae0\u4e2d\uff0c\u4f5c\u8005\u6784\u5efa\u4e86\u7ec6\u83cc\u751f\u957f\u7684\u7edf\u4e00\u56fe\u666f\u2014\u2014\u7ec6\u83cc\u901a\u7528\u7684\u81ea\u50ac\u5316\u7f51\u7edc\u6846\u67b6\uff0c\u5e76\u901a\u8fc7\u63a8\u5bfc\u8bf4\u660e\uff0c\u81ea\u50ac\u5316\u7f51\u7edc\u4e4b\u95f4\u7684\u5173\u7cfb\u5982\u4f55\u4fc3\u8fdb\u5355\u4e00\u7ec6\u80de\u7684\u5747\u8861\u6307\u6570\u7ea7\u589e\u957f\u3002\u8fd9\u5176\u4e2d\u7684\u6838\u5fc3\u662f\u8f6c\u5f55-\u7ffb\u8bd1\u673a\u5668\uff0c\u8be5\u673a\u5668\u5305\u542b\u4e86\u51e0\u4e2a\u8026\u5408\u7684\u81ea\u50ac\u5316\u5faa\u73af\uff1a\u6838\u7cd6\u4f53\u5faa\u73af\u3001RNA\u805a\u5408\u9176\u5faa\u73af\u3001\u8f6c\u8fd0RNA\u88c5\u8f7d\u5faa\u73af<\/span>\uff08tRNA charging cycle\uff09<\/span>\u3002\u57fa\u4e8e\u8be5\u5faa\u73af\uff0c\u4f5c\u8005\u63a8\u5bfc\u5faa\u73af\u5bf9\u5e94\u7684\u751f\u957f\u89c4\u5f8b\uff0c\u5e76\u7ed3\u5408\u5b9e\u9a8c\u6570\u636e\u9a8c\u8bc1\u8be5\u89c4\u5f8b\uff0c\u63a8\u6d4b\u7ec6\u83cc\u7684\u751f\u957f\u901f\u7387\u5982\u4f55\u53d7\u6e29\u5ea6\u3001\u9776\u5411\u836f\u7269\u7b49\u56e0\u7d20\u5f71\u54cd\u3002<\/span><\/p>\n


<\/section>\n
 <\/span>
<\/section>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

\u4e00\u3001\u5f15\u5165<\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/h3>\n

1\u3001\u7ec6\u80de\u5185\u7684\u81ea\u50ac\u5316\u5faa\u73af<\/span><\/strong><\/span><\/span><\/h3>\n


<\/p>\n

\u901a\u7528\u6784\u9020\u673a\u662f\u51af\u00b7\u8bfa\u4f9d\u66fc\u8bbe\u8ba1\u7684\u4e00\u79cd\u673a\u5668\uff0c\u5b83\u80fd\u591f\u901a\u8fc7\u83b7\u53d6\u6307\u4ee4\u3001\u6d88\u8017\u6750\u6599\u5efa\u9020\u5305\u62ec\u81ea\u5df1\u5728\u5185\u7684\u4e00\u4e9b\u673a\u5668\uff0c\u56e0\u6b64\u662f\u81ea\u590d\u5236<\/strong>\u7684\u3002\u7ec6\u80de\u4f5c\u4e3a\u80fd\u591f\u81ea\u590d\u5236\u7684\u4e2a\u4f53\uff0c\u5b83\u7684\u8f6c\u5f55-\u7ffb\u8bd1\u673a\u5668\u53ef\u4ee5\u4f5c\u4e3a\u51af\u00b7\u8bfa\u4f9d\u66fc\u901a\u7528\u6784\u9020\u673a\u7684\u4e00\u4e2a\u4f53\u73b0\uff0c\u800c\u8fd9\u79cd\u673a\u5668\u4e5f\u6b63\u662f\u81ea\u590d\u5236\u5355\u7ec6\u80de\u751f\u7269\u7684\u6838\u5fc3\u3002<\/span><\/p>\n


<\/p>\n

\u8f6c\u5f55-\u7ffb\u8bd1\u673a\u5668\u7531RNA<\/strong>\u805a\u5408\u9176<\/strong>\u4ee5\u53ca\u6838\u7cd6\u4f53<\/strong>\u8fd9\u4e24\u4e2a\u5173\u952e\u5206\u5b50\u673a\u5668\u6784\u6210\u3002\u6839\u636e\u4e2d\u5fc3\u6cd5\u5219\uff0c\u7ec6\u80de\u4e2d\u7684\u6240\u6709\u86cb\u767d\u8d28\u5747\u7531\u8fd9\u5957\u6838\u5fc3\u673a\u5668\u5206\u4e24\u6b65\u5408\u6210\uff1a\u5148\u662fRNA\u805a\u5408\u9176\u8f6c\u5f55\u57fa\u56e0\u3001\u5f62\u6210\u201c\u6307\u4ee4\u96c6\u201dmRNA\uff1b\u7136\u540e\u6838\u7cd6\u4f53\u901a\u8fc7\u7ffb\u8bd1mRNA\u751f\u6210\u86cb\u767d\u8d28\u3002<\/span><\/p>\n


<\/p>\n

\u8981\u6210\u4e3a\u4e00\u4e2a\u201c\u901a\u7528\u6784\u9020\u673a\u201d\uff0c\u8f6c\u5f55-\u7ffb\u8bd1\u673a\u5668\u5fc5\u987b\u80fd\u591f\u81ea\u6211\u590d\u5236\u3002\u8f6c\u5f55-\u7ffb\u8bd1\u673a\u5668\u7684\u81ea\u590d\u5236\u662f\u4e2a\u590d\u6742\u3001\u4f46\u6240\u6709\u5355\u7ec6\u80de\u751f\u7269\u5747\u4ff1\u5907\u7684\u8fc7\u7a0b\u3002\u8be5\u81ea\u590d\u5236\u8fc7\u7a0b\u7531\u4e24\u4e2a\u91cd\u8981\u7684\u81ea\u50ac\u5316\u5faa\u73af\u6240\u6784\u6210\uff1aRNA\u805a\u5408\u9176\u81ea\u50ac\u5316\u5faa\u73af<\/strong>\u4ee5\u53ca\u6838\u7cd6\u4f53\u81ea\u50ac\u5316\u5faa\u73af<\/strong>\u3002\u5982\u679cRNA\u805a\u5408\u9176\u6ca1\u6709\u8f6c\u5f55\u51fa\u6838\u7cd6\u4f53RNA<\/span>\uff08rRNA\uff09<\/span>\uff0c\u7ec6\u80de\u5c31\u4e0d\u80fd\u4ece\u5934\u5408\u6210\u65b0\u7684\u6838\u7cd6\u4f53\uff1b\u540c\u7406\uff0c\u5982\u679c\u6ca1\u6709\u6838\u7cd6\u4f53\u7ffb\u8bd1\u51faRNA\u805a\u5408\u9176\u86cb\u767d\u4e9a\u57fa\u5bf9\u5e94\u7684mRNA\uff0cRNA\u805a\u5408\u9176\u7684\u4ece\u5934\u5408\u6210\u4e5f\u5c31\u4e0d\u80fd\u5b9e\u73b0\u3002\u56e0\u6b64\uff0c\u4e24\u4e2a\u5faa\u73af\u662f\u8026\u5408\u7684\uff0c\u4e14\u90fd\u5305\u62ec\u81ea\u7ec4\u88c5\u7684\u6b65\u9aa4\u3002<\/span><\/p>\n


<\/p>\n

RNA\u805a\u5408\u9176\u548c\u6838\u7cd6\u4f53\u7684\u81ea\u50ac\u5316\u5faa\u73af\u4e5f\u90fd\u4f9d\u8d56\u4e8e\u5176\u4ed6\u7684\u81ea\u50ac\u5316\u5faa\u73af\uff0c\u8fd9\u4e9b\u5faa\u73af\u4e5f\u662f\u8f6c\u5f55-\u7ffb\u8bd1\u673a\u5668\u7684\u7ec4\u6210\u90e8\u5206\uff0c\u5b83\u4eec\u8d1f\u8d23tRNA\u4e0e\u6c28\u57fa\u9178\u7684\u7ed3\u5408\u3001\u534f\u52a9\u6838\u7cd6\u4f53\u7ffb\u8bd1\u8fc7\u7a0b\u7684\u542f\u52a8\u3001\u79fb\u4f4d\u548c\u7ec8\u6b62\u7b49\u7b49\u3002\u6240\u6709\u7684\u81ea\u50ac\u5316\u5faa\u73af\u76f8\u4e92\u4ea4\u7ec7\uff0c\u5f7c\u6b64\u9700\u8981\uff0c\u79fb\u9664\u5176\u4e2d\u4efb\u4f55\u4e00\u4e2a\u5faa\u73af\u7684\u4efb\u610f\u4e00\u4e2a\u5173\u952e\u7684\u50ac\u5316\u5242\u90fd\u4f1a\u7834\u574f\u6240\u6709\u7684\u81ea\u50ac\u5316\u5faa\u73af\u3002<\/span><\/p>\n


<\/span><\/p>\n

2\u3001\u7ec6\u83cc\u751f\u957f\u89c4\u5f8b<\/span><\/strong><\/span><\/span><\/h3>\n


<\/p>\n

\u7ec6\u83cc\u751f\u957f\u89c4\u5f8b<\/span>\uff08growth law\uff09<\/span>\u65e8\u5728\u7814\u7a76\u5728\u5ffd\u7565\u7ec6\u80de\u5185\u56e0\u76f8\u4e92\u5e72\u6270\u7684\u60c5\u51b5\u4e0b\uff0c\u7ec6\u83cc\u751f\u957f\u6240\u8868\u73b0\u51fa\u7684\u6574\u4f53\u7279\u5f81\u4e0e\u67d0\u4e00\u7ec4\u5206\u4e4b\u95f4\u7b80\u5355\u7684\u6570\u5b66\u5173\u7cfb\u3002\u4f8b\u5982\uff1a\u56fe1a\u8868\u793a\u4e86\u4e00\u7ec4\u7ec6\u83cc\u751f\u957f\u901f\u7387\u03bb\u4e0e\u6838\u7cd6\u4f53\u8d28\u91cf\u5206\u6570<\/span>\uff08\u7eb5\u8f74\uff0c\u7531\u4e8e\u6838\u7cd6\u4f53RNA\u5360RNA\u7ea6\u4e3a85%\uff0c\u56e0\u6b64RNA\/\u603b\u86cb\u767d\u6bd4\u7387\u4e0e\u6838\u7cd6\u4f53\u8d28\u91cf\u5206\u6570\u7ebf\u6027\u76f8\u5173\uff09<\/span>\u4e4b\u95f4\u7684\u5173\u7cfb\uff1a\u5f53\u7ffb\u8bd1\u5de5\u4f5c\u6b63\u5e38\u65f6\uff0c\u751f\u957f\u901f\u7387\u4e0e\u6838\u7cd6\u4f53\u8d28\u91cf\u5206\u6570\u5448\u7ebf\u6027\u6b63\u76f8\u5173<\/span>\uff08\u7528\u5b9e\u7ebf\u8868\u793a\uff09<\/span>\uff1b\u5f53\u7ffb\u8bd1\u53d7\u5230\u6291\u5236\u65f6\uff0c\u751f\u957f\u901f\u7387\u4e0e\u6838\u7cd6\u4f53\u7684\u5173\u7cfb\u5448\u8d1f\u76f8\u5173<\/span>\uff08\u7528\u865a\u7ebf\u8868\u793a\uff09<\/span>\uff1b\u5f53\u5b8c\u5168\u6291\u5236\u65f6\uff0c\u8d28\u91cf\u5206\u6570\u6536\u655b\u4e8e\u4ea4\u70b9\u5904\uff0c\u8be5\u70b9\u8868\u793a\u4e86\u7ffb\u8bd1\u5b8c\u5168\u53d7\u9650\u7684\u60c5\u51b5\u4e0b\u6838\u7cd6\u4f53\u5de5\u4f5c\u7684\u5206\u914d\u60c5\u51b5\u3002\u4e0e\u56fe1a\u76f8\u4f3c\uff0c\u56fe1b\u8868\u793a\u4e86\u4e0d\u540c\u60c5\u51b5\u4e0b\u751f\u957f\u901f\u7387\u4e0e\u975e\u6838\u7cd6\u4f53\u86cb\u767d\u6570\u91cf<\/span>\uff08\u56fe1c\u4e2d\u7c89\u8272\u7684\u90e8\u5206\uff09<\/span>\u7684\u7ebf\u6027\u5173\u7cfb\u3002<\/span><\/p>\n


<\/span><\/p>\n

<\/p>\n

\u56fe1. \u4e00\u4e9b\u7ec6\u83cc\u7684\u751f\u957f\u89c4\u5f8b[1]<\/span><\/p>\n


<\/p>\n

\u6838\u7cd6\u4f53\u4e2d\u5fc3\u8bba<\/span><\/strong>\uff08ribo-centric\uff09<\/span>\u805a\u7126\u4e8e\u201c\u6838\u7cd6\u4f53\u5236\u9020\u6838\u7cd6\u4f53\u201d\u7684\u6838\u7cd6\u4f53\u81ea\u50ac\u5316\u5faa\u73af\uff0c\u5b83\u7684\u751f\u957f\u89c4\u5f8b\u7814\u7a76\u5c06\u7ec6\u83cc\u751f\u957f\u901f\u7387\u4e0e\u6838\u7cd6\u4f53\u86cb\u767d\u8d28\u8d28\u91cf\u5206\u6570\u3001\u6838\u7cd6\u4f53\u7ffb\u8bd1\u901f\u7387\u5b9a\u91cf\u8054\u7cfb\u4e86\u8d77\u6765\u3002\u6838\u7cd6\u4f53\u4e2d\u5fc3\u8bba\u4e5f\u6709\u5176\u77ed\u677f\u2014\u2014\u5ffd\u89c6\u4e86\u4e2d\u5fc3\u6cd5\u5219\u4e2d\u7684\u8f6c\u5f55\u90e8\u5206\uff0c\u540c\u65f6\u4e5f\u5ffd\u89c6\u4e86\u7ec6\u80de\u5185\u5176\u4ed6\u7684\u81ea\u50ac\u5316\u5faa\u73af<\/strong>\u3002\u6bd4\u5982\uff0c\u5f53\u6e29\u5ea6\u6216\u8f6c\u5f55\u53d1\u751f\u5fae\u6270\u65f6\uff0c\u751f\u957f\u901f\u7387\u4f1a\u660e\u663e\u6539\u53d8\uff1b\u800c\u4ee5\u5f80\u7684\u6838\u7cd6\u4f53\u751f\u957f\u89c4\u5f8b\u5374\u8ba4\u4e3a\uff0c\u8be5\u6270\u52a8\u5e76\u4e0d\u4f1a\u4f7f\u6838\u7cd6\u4f53\u7684\u8d28\u91cf\u5206\u6570\u53d1\u751f\u6539\u53d8\u3002\u56e0\u6b64\uff0c\u9700\u8981\u66f4\u5408\u9002\u7684\u6a21\u578b\u53bb\u89e3\u91ca\u8fd9\u4e00\u504f\u5dee\u3002<\/span><\/p>\n


<\/p>\n

\u5728\u8fd9\u4e2a\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u517c\u987e\u4e86\u8f6c\u5f55\u4e0e\u7ffb\u8bd1\uff0c\u63a8\u5bfc\u51fa\u57fa\u4e8e\u8f6c\u5f55-\u7ffb\u8bd1\u673a\u5668\u7684\u81ea\u50ac\u5316\u7684\u751f\u957f\u89c4\u5f8b<\/strong>\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u53d1\u73b0\u5728\u6240\u6709\u7ec6\u83cc\u5185\uff0c\u8f6c\u5f55\u4e0e\u7ffb\u8bd1\u8fc7\u7a0b\u5747\u8026\u5408\u4e86\u5176\u4ed6\u7684\u81ea\u50ac\u5316\u5faa\u73af\uff0c\u800c\u4e0d\u9700\u8981\u5176\u4ed6\u590d\u6742\u7684\u53cd\u9988\u3002\u8fd9\u79cd\u8026\u5408\u9501\u5b9a\u4e86\u6240\u6709\u5faa\u73af\uff0c\u4f7f\u6240\u6709\u7ec4\u5206\u4fdd\u6301\u76f8\u540c\u7684\u751f\u957f\u901f\u7387\uff0c\u7ec6\u80de\u5f97\u4ee5\u5448\u73b0\u5747\u8861\u7684\u6307\u6570\u589e\u957f\u72b6\u6001<\/span>\uff08balanced exponential growth\uff09<\/span>\u3002<\/span><\/p>\n


<\/span><\/p>\n

<\/p>\n

\u56fe2. \u7ec6\u83cc\u7684\u81ea\u50ac\u5316\u7f51\u7edc\u793a\u610f\u56fe<\/span><\/p>\n


<\/p>\n

\u7ec6\u83cc\u7684\u81ea\u50ac\u5316\u7f51\u7edc\u5982\u56fe2\u6240\u793a\u3002\u5de6\u4e0a\u89d2\u7684\u56fe\u4f8b\u5c55\u793a\u4e86\u5e95\u7269\u3001\u4ea7\u7269\u4ee5\u53ca\u50ac\u5316\u5242\u6784\u6210\u7684\u5b8c\u6574\u81ea\u50ac\u5316\u4f53\u7cfb\uff0c\u5176\u4e2d\u7684\u56fe\u4f8b\u5143\u4ef6\u542b\u4e49\u5982\u4e0b\uff1a<\/span><\/section>\n
    \n
  • \n
    \u65b9\u6846\uff1a<\/span>\u81ea\u50ac\u5316\u5faa\u73af\u7684\u53cd\u5e94\u63cf\u8ff0<\/span><\/section>\n<\/li>\n
  • \n
    \u5b9e\u5f00\u653e\u6846\uff1a<\/span>\u5e95\u7269\uff0c\u88ab\u53cd\u5e94\u6240\u6d88\u8017<\/span><\/section>\n<\/li>\n
  • \n
    \u865a\u5f00\u653e\u6846\uff08\u542b\u7bad\u5934\uff09\uff1a<\/span>\u50ac\u5316\u5242\uff0c\u50ac\u5316\u53cd\u5e94\u4f46\u4e0d\u4f1a\u6d88\u8017<\/span><\/section>\n<\/li>\n
  • \n

    \u7bad\u5934\uff1a<\/span>\u53cd\u5e94\u4ea7\u7269\uff0c\u6d41\u5411\u5176\u4ed6\u7684\u5faa\u73af\u6216\u9000\u51fa\u5faa\u73af<\/span><\/p>\n<\/li>\n<\/ul>\n

    <\/span><\/section>\n

    <\/section>\n

    \u56fe\u4e2d\u7684\u81ea\u50ac\u5316\u7f51\u7edc\u4e00\u5171\u5c55\u793a\u4e864\u7ec4\u8026\u5408\u7684\u81ea\u50ac\u5316\u5faa\u73af\uff0c\u5206\u522b\u662f\uff1a<\/span><\/p>\n

      \n
    1. \n
      \u8f6c\u5f55-\u7ffb\u8bd1\u5faa\u73af<\/strong>\uff1a\u6d88\u8017\u539f\u6750\u6599\u548c\u80fd\u91cf\uff0c\u4ea7\u51fa\u5305\u62ec\u81ea\u8eab\u7684\u6240\u6709\u86cb\u767d\u8d28\u53ca\u526f\u672c\uff0c\u63d0\u4f9b\u5927\u90e8\u5206\u5faa\u73af\u7684\u50ac\u5316\u5242<\/span><\/span><\/section>\n<\/li>\n
    2. \n
      \u4ee3\u8c22\u5faa\u73af\uff1a\u5c06\u5916\u6e90\u4ee3\u8c22\u7269\u8f6c\u5316\u4e3a\u6838\u82f7\u9178\u3001\u6c28\u57fa\u9178\u3001\u8102\u80aa\u9178\u7b49\u4ee3\u8c22\u4ea7\u7269\uff0c\u63d0\u4f9b\u5927\u90e8\u5206\u5faa\u73af\u7684\u5e95\u7269<\/span><\/section>\n<\/li>\n
    3. \n
      DNA\u590d\u5236\u5faa\u73af\uff1a\u5229\u7528DNA\u4f5c\u4e3a\u6a21\u677f\u590d\u5236\u5176\u81ea\u8eab<\/span><\/section>\n<\/li>\n
    4. \n
      \u819c\u5408\u6210\u5faa\u73af\uff1a\u901a\u8fc7\u819c\u5408\u6210\u86cb\u767d\u50ac\u5316\u5408\u6210\u819c\u7ed3\u6784<\/span><\/section>\n<\/li>\n<\/ol>\n

      <\/section>\n
       <\/span>
      <\/section>\n

      \n
      \n
      \n
      \n
      \n

      <\/section>\n

      <\/section>\n
      \n
      <\/svg><\/section>\n<\/section>\n<\/section>\n
      \n

      \u4e8c\u3001\u7ed3\u679c\uff1a\u8f6c\u5f55-\u7ffb\u8bd1\u673a\u5668<\/strong><\/strong><\/p>\n

      \u5229\u7528\u591a\u4e2a\u8026\u5408\u7684\u81ea\u50ac\u5316\u5faa\u73af\u5b9e\u73b0\u81ea\u590d\u5236<\/strong><\/strong><\/p>\n<\/section>\n

      \n

      <\/section>\n

      <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


      <\/p>\n

      \u5982\u56fe3\u6240\u793a\uff0c\u8f6c\u5f55-\u7ffb\u8bd1\u673a\u5668\u7684\u81ea\u590d\u5236\u8fc7\u7a0b\u4e3b\u8981\u7531\u4e09\u4e2a\u8026\u5408\u7684\u81ea\u50ac\u5316\u5faa\u73af\u7ec4\u6210\uff1a\u6838\u7cd6\u4f53\u5faa\u73af\u3001RNA\u805a\u5408\u9176\u5faa\u73af\u3001tRNA\u88c5\u8f7d\u5faa\u73af\uff0c\u5177\u4f53\u5982\u4e0b\uff1a<\/span><\/p>\n

        \n
      1. \n
        \u6838\u7cd6\u4f53\u81ea\u50ac\u5316\u5faa\u73af\uff1a\u5305\u542b\u6838\u7cd6\u4f53\u5408\u6210\u6838\u7cd6\u4f53\u86cb\u767d\uff0cRNA\u805a\u5408\u9176\u5408\u6210rRNA\u4e24\u90e8\u5206\uff0c\u7136\u540e\u6838\u7cd6\u4f53\u86cb\u767d\u4e0erRNA\u81ea\u7ec4\u88c5\u5f62\u6210\u65b0\u7684\u6838\u7cd6\u4f53<\/span><\/section>\n<\/li>\n
      2. \n
        RNA\u805a\u5408\u9176\u5faa\u73af\uff1aRNA\u805a\u5408\u9176\u8f6c\u5f55mRNA\uff0c\u7ffb\u8bd1\u4ea7\u751fRNA\u805a\u5408\u9176\u86cb\u767d\u4e9a\u57fa\uff0c\u540e\u8005\u7ecf\u8fc7\u81ea\u7ec4\u88c5\u5f62\u6210\u65b0\u7684RNA\u805a\u5408\u9176<\/span><\/section>\n<\/li>\n
      3. \n
        tRNA\u88c5\u8f7d\u5faa\u73af\uff1a\u6c28\u9170tRNA\u5408\u6210\u9176\u50ac\u5316tRNA\u7684\u6c28\u57fa\u9178\u88c5\u8f7d\u5de5\u4f5c\uff0c\u800c\u540etRNA\u8fd0\u8f93\u7684\u6c28\u57fa\u9178\u53c2\u4e0e\u5230\u4e86\u6838\u7cd6\u4f53\u7684mRNA\u7ffb\u8bd1\u8fc7\u7a0b\u4e4b\u4e2d\uff0c\u8fd9\u5176\u4e2d\u5c31\u5305\u62ec\u4e86\u6c28\u9170tRNA\u5408\u6210\u9176\u7684mRNA<\/span><\/section>\n<\/li>\n
      4. \n
        \u4efb\u4f55\u5168\u5c40\u672a\u88ab\u6d88\u8017\u7684\u5e95\u7269\u5747\u53ef\u89c6\u4f5c\u50ac\u5316\u5242\uff0c\u5982mRNA\u4e4b\u4e8e\u86cb\u767d\u5408\u6210\u53cd\u5e94<\/span><\/section>\n<\/li>\n
      5. \n

        \u5176\u4f59\u4e0e\u7ffb\u8bd1\u76f8\u5173\u7684\u5faa\u73af\u4e0d\u505a\u8ba8\u8bba<\/span><\/p>\n<\/li>\n<\/ol>\n


        <\/section>\n

        <\/section>\n
        <\/section>\n
        \u56fe3.\u7ec6\u83cc\u7684\u81ea\u50ac\u5316\u7f51\u7edc\u793a\u610f\u56fe<\/span><\/section>\n

        <\/section>\n

        1\u3001\u6838\u7cd6\u4f53\u81ea\u50ac\u5316\u5faa\u73af<\/span><\/strong><\/span><\/h3>\n

        <\/section>\n
        \u4ece\u5934\u5408\u6210\u6838\u7cd6\u4f53\uff0c\u9700\u8981RNA\u805a\u5408\u9176\u8f6c\u5f55\u51famRNA\u4ee5\u53carRNA\uff0c\u7136\u540e\u4ee5mRNA\u4e3a\u6a21\u7248\u7ffb\u8bd1\u6210\u6838\u7cd6\u4f53\u86cb\u767d\uff0c\u6e38\u79bb\u4e00\u6bb5\u65f6\u95f4\u540e\u8fdb\u5165\u6838\u7cd6\u4f53\u7684\u7ec4\u88c5\u7ebf\u4e2d\uff0c\u6309\u7167\u4e9a\u57fa\u7684\u7ec4\u88c5\u987a\u5e8f\u4f9d\u6b21\u5d4c\u5165\u6838\u7cd6\u4f53\u4e2d\u3002\u5047\u5b9arRNA\u662f\u5145\u8db3\u7684\uff0c\u5219\u63a8\u5bfc\u6838\u7cd6\u4f53\u86cb\u767d\u7684\u81ea\u50ac\u5316\u5faa\u73af\uff0c\u53ea\u9700\u8003\u8651\u6838\u7cd6\u4f53\u7528\u4e8e\u5408\u6210\u6838\u7cd6\u4f53\u86cb\u767d\u7684\u8d28\u91cf\u5206\u6570\u3002<\/span><\/section>\n

        <\/span><\/section>\n
        \u5c06\u4e0a\u8ff0\u7684\u4e00\u7cfb\u5217\u6b65\u9aa4\u4e32\u8054\u8d77\u6765\uff0c\u4f5c\u8005\u901a\u8fc7\u63a8\u5bfc\u8026\u5408\u7684\u5e38\u5fae\u5206\u65b9\u7a0b<\/span>\uff08\u6838\u7cd6\u4f53\u86cb\u767d\u4e30\u5ea6\u53d8\u5316\u901f\u7387\u3001\u6d3b\u6027\u7ec4\u88c5\u6001\uff08active assembling state\uff09\u7684\u8f6c\u5316\u901f\u7387\u3001\u6574\u5408\u65b0\u6838\u7cd6\u4f53\u7684\u901f\u7387\u3001\u9759\u6001\u6fc0\u6d3b\u6001\u76f8\u4e92\u8f6c\u5316\u901f\u7387\uff09<\/span>\uff0c\u5f97\u51fa\u6838\u7cd6\u4f53\u5faa\u73af\u7684\u751f\u957f\u89c4\u5f8b\u3002\u5e76\u8fdb\u4e00\u6b65\u5047\u8bbe\u6838\u7cd6\u4f53\u7ec4\u88c5\u65f6\u95f4\u4e0e\u6838\u7cd6\u4f53\u5728\u524d\u4f53\u6c60\u4e2d\u7684\u6e38\u79bb\u65f6\u95f4\u8fdc\u5c0f\u4e8e\u500d\u589e\u65f6\u95f4<\/strong>\uff0c\u5219\u6709\u7b80\u5316\u5f0f\uff1a<\/span><\/section>\n

        <\/span><\/section>\n

        <\/p>\n


        <\/span><\/section>\n

        <\/p>\n


        <\/section>\n
        \u5728\u5148\u524d\u5047\u8bbe\u6210\u7acb\u7684\u60c5\u51b5\u4e0b\uff0c\u8be5\u5f0f\u7b49\u4ef7\u4e8e\u8457\u540d\u7684\u7ec6\u83cc\u751f\u957f\u89c4\u5f8b\uff1a<\/sub>\uff0c\u540e\u8005\u5728\u5b9e\u9a8c\u4e2d\u5f97\u5230\u9a8c\u8bc1\u3002\u5219\u6838\u7cd6\u4f53\u8d28\u91cf\u5206\u6570<\/sub><\/span>\u7b49\u4ef7\u4e8e\u6838\u7cd6\u4f53\u5206\u914d\u7cfb\u6570<\/span><\/sub><\/span>\uff0c\u5373\u5206\u914d\u7528\u4e8e\u7ffb\u8bd1\u6838\u7cd6\u4f53\u86cb\u767d\u7684\u6838\u7cd6\u4f53\u8d28\u91cf\u5206\u6570\u3002\u5047\u8bbe\u7684\u6709\u6548\u6027\u3001\u6838\u7cd6\u4f53\u5206\u914d\u7cfb\u6570\u4e0e\u6838\u7cd6\u4f53\u8d28\u91cf\u5206\u6570\u7684\u7b49\u4ef7\u6027\u5747\u5f97\u5230\u4e86\u5b9e\u9a8c\u9a8c\u8bc1\u3002\u7136\u800c\uff0c\u5f53\u524d\u63d0\u5047\u8bbe\u5931\u6548<\/span>\uff08\u6bd4\u5982\u6838\u7cd6\u4f53\u7ec4\u88c5\u65f6\u95f4\u5ef6\u957f\uff09<\/span>\u65f6\uff0c\u8d28\u91cf\u5206\u6570\u4e0e\u5206\u914d\u7cfb\u6570\u7684\u504f\u5dee\u4e0d\u80fd\u518d\u5ffd\u89c6\uff0c\u800c\u4f5c\u8005\u7684\u6a21\u578b\u4e5f\u9884\u6d4b\u5230\u4e86\u8fd9\u4e2a\u504f\u5dee\uff0c\u5747\u53ef\u7531\u5b9e\u9a8c\u6240\u8bc1\u5b9e<\/span>\uff08\u89c1\u7b2c\u4e09\u90e8\u5206\u7b2c2\u5c0f\u8282\uff09<\/span>\u3002<\/span><\/section>\n

        <\/span><\/section>\n
        \u7531\u4e8e\u6838\u7cd6\u4f53\u662frRNA\u548c\u6838\u7cd6\u4f53\u86cb\u767d\u81ea\u7ec4\u88c5\u800c\u6210\uff0c\u4e0e\u4e0a\u8ff0\u6b65\u9aa4\u76f8\u4f3c\uff0c\u57fa\u4e8e\u53e6\u4e00\u7ec4\u5e38\u5fae\u5206\u65b9\u7a0b<\/span>\uff08RNA\u805a\u5408\u9176\u4e9a\u57fa\u7684\u4e30\u5ea6\u53d8\u5316\u901f\u7387\u3001\u6fc0\u6d3b\u4e3a\u8f6c\u5f55\u72b6\u6001\u7684\u901f\u7387\u3001RNA\u805a\u5408\u9176\u8f6c\u5f55rRNA\u7684\u901f\u7387\u3001\u7ec4\u88c5\u540e\u7684rRNA\u4ea7\u51fa\u65b0\u6838\u7cd6\u4f53\u7684\u901f\u7387\uff09<\/span>\uff0c\u4f5c\u8005\u63a8\u5bfc\u51fa\u4e86\u57fa\u4e8erRNA\u7684\u6838\u7cd6\u4f53\u7684\u751f\u957f\u89c4\u5f8b<\/strong>\uff0c\u5047\u8bbe\u6210\u7acb\u7684\u60c5\u51b5\u4e0b\uff0c\u8be5\u5f0f\u7b49\u4ef7\u4e8e\u4e4b\u524d\u53d1\u73b0\u7684rRNA\u81ea\u50ac\u5316\u751f\u957f\u89c4\u5f8b\u3002<\/span><\/section>\n


        <\/p>\n

        2\u3001RNA\u805a\u5408\u9176\u81ea\u50ac\u5316\u5faa\u73af<\/span><\/strong><\/span><\/h3>\n

        <\/section>\n
        \u201cRNA\u805a\u5408\u9176\u751f\u6210RNA\u805a\u5408\u9176\u201d\u8fd9\u6837\u7684\u81ea\u50ac\u5316\u5faa\u73af\uff0c\u5176\u5de5\u4f5c\u539f\u7406\u5982\u4e0b\uff1a\u5177\u6709\u6d3b\u6027\u7684\u4e00\u90e8\u5206RNA\u805a\u5408\u9176\u88ab\u5206\u914d\u8f6c\u5f55rpo<\/span>\uff08RNA\u805a\u5408\u9176\uff09<\/span>\u57fa\u56e0\uff0c\u751f\u6210mRNA\uff1b\u540c\u65f6\uff0c\u4e00\u90e8\u5206\u6d3b\u6027\u6838\u7cd6\u4f53\u88ab\u5206\u914d\u7ffb\u8bd1\u8fd9\u4e9bmRNA\u3001\u5408\u6210RNA\u805a\u5408\u9176\u4e9a\u57fa\u3002\u805a\u5408\u9176\u4e9a\u57fa\u968f\u540e\u4f1a\u81ea\u7ec4\u88c5\u3001\u5f62\u6210\u65b0\u7684RNA\u805a\u5408\u9176\u3002<\/span><\/section>\n

        <\/section>\n
        RNA\u805a\u5408\u9176\u751f\u957f\u89c4\u5f8b\u7531\u4f5c\u8005\u5c06\u8026\u5408\u7684\u5e38\u5fae\u5206\u65b9\u7a0b<\/span>\uff08rpo\u57fa\u56e0\u8f6c\u5f55\u6210\u4e3amRNA\u7684\u53d8\u5316\u901f\u7387\u3001Rpo\u86cb\u767d\u4e9a\u57fa\u53d8\u5316\u901f\u7387\u3001\u7ec4\u88c5\u540e\u7684Rpo\u86cb\u767d\u4e9a\u57fa\u4e0a\u4ea7\u51fa\u65b0RNA\u805a\u5408\u9176\u7684\u901f\u7387\u3001\u6d3b\u6027RNA\u805a\u5408\u9176\u5206\u914d\u7ed9\u8f6c\u5f55rpo\u57fa\u56e0\u7684\u8d28\u91cf\u5206\u6570\uff09<\/span>\u8054\u7acb\u800c\u5f97\uff0c\u5e76\u91c7\u7528\u4e86\u4e24\u7ec4\u8fd1\u671f\u7684\u5b9e\u9a8c\u6570\u636e\u4ee5\u9a8c\u8bc1RNA\u805a\u5408\u9176\u751f\u957f\u89c4\u5f8b\u6a21\u578b\u3002<\/span><\/section>\n

        <\/span><\/section>\n
        \u4f5c\u8005\u91c7\u7528\u4e86\u4e24\u7ec4\u8fd1\u671f\u7684\u5b9e\u9a8c\u6570\u636e\u4ee5\u9a8c\u8bc1\u8be5RNA\u805a\u5408\u9176\u751f\u957f\u89c4\u5f8b\u6a21\u578b\u7684\u6548\u679c\uff1a\u7b2c\u4e00\u7ec4\u5b9e\u9a8c\u4e2d<\/strong>\u7684\u7814\u7a76\u8005\u8bbe\u8ba1\u4e86\u4e00\u79cd\u5927\u80a0\u6746\u83cc\u7684\u53ef\u9006\u751f\u957f\u5f00\u5173\uff0c\u8be5\u5f00\u5173\u901a\u8fc7\u79fb\u9664\u57fa\u56e0\u7ec4\u4e2d\u7684RNA\u805a\u5408\u9176\u4e9a\u57farpoBC\u7684\u57fa\u56e0\uff0c\u6784\u5efa\u5728\u5305\u542b\u8bf1\u5bfc\u6027\u542f\u52a8\u5b50\u4ee5\u53ca\u8367\u5149\u6807\u8bb0\u7269\u7684\u8d28\u7c92\u4e4b\u4e2d\u3002rpoBC\u57fa\u56e0\u7684\u8868\u8fbe\u53ef\u7531\u5916\u6e90IPTG\u7684\u6d53\u5ea6\u6240\u8bf1\u5bfc\uff0cIPTG\u6d53\u5ea6\u5347\u9ad8\uff0c\u53ef\u4ee5\u89c2\u6d4b\u8f83\u7a33\u5b9a\u7684\u83cc\u4f53\u751f\u957f\u901f\u7387\uff1b\u7136\u800c\u5f53IPTG\u6d53\u5ea6\u4e0b\u964d\uff0c\u5219\u89c2\u6d4b\u5230\u751f\u957f\u901f\u7387\u6709\u5f88\u660e\u663e\u7684\u4e0b\u964d\u3002<\/span><\/section>\n

        <\/span><\/section>\n
        \u5f53IPTG\u6d53\u5ea6\u964d\u4f4e\u65f6\uff0c\u8bf1\u5bfc\u8868\u8fbe\u51cf\u5c11\uff0c\u5219\u805a\u5408\u9176\u86cb\u767d\u4e9a\u57faRopB\u7684\u6e38\u79bb\u6c60\u51cf\u5c11\uff0c\u65b0\u7684RNA\u805a\u5408\u9176\u7ec4\u88c5\u65f6\u95f4\u5c06\u589e\u52a0\u3002\u7ed3\u5408\u7ec4\u88c5\u8fc7\u7a0b\u4e2d\u6d88\u8017\u901f\u7387\u3001\u8367\u5149\u8870\u51cf\u7684\u901f\u7387\u4ee5\u53caRpoB\u4f9b\u7ed9\u7684\u60c5\u51b5\uff0c\u4fee\u6b63\u540e\u7684\u7ec4\u88c5\u65f6\u95f4\u53ef\u4ee5\u7528\u6765\u8868\u793a\u751f\u957f\u901f\u7387<\/span>\uff08\u56fe4B\uff09<\/span>\u3002\u751f\u957f\u89c4\u5f8b\u5728\u4e09\u7ec4\u6761\u4ef6\u4e2d\u5747\u5f97\u5230\u4e86\u8f83\u597d\u7684\u62df\u5408\u6548\u679c<\/span>\uff08\u56fe4C\uff09<\/span>\u3002<\/span><\/section>\n

        <\/span><\/section>\n
        <\/section>\n
        \u56fe4.RNA\u805a\u5408\u9176\u7684\u751f\u957f\u89c4\u5f8b\u53ca\u5b9e\u9a8c\u6570\u636e\u62df\u5408\u5f0f<\/span><\/section>\n


        <\/p>\n

        \u7b2c\u4e8c\u7ec4\u5b9e\u9a8c\u4e2d<\/span><\/strong>\uff0c\u7814\u7a76\u8005\u91c7\u7528\u4e86\u5728\u8f6c\u5f55RNA\u8d77\u59cb\u8fc7\u7a0b\u4e2d\uff0c\u9776\u5411DNA\u4e0eRNA\u805a\u5408\u9176\u7ed3\u5408\u7684\u836f\u5242\u5229\u798f\u5e73<\/span>\uff08rifampicin\uff09<\/span>\u3002\u7814\u7a76\u8005\u9488\u5bf9\u5927\u80a0\u6746\u83cc\u91c7\u7528\u4e86\u4e9a\u81f4\u6b7b\u5242\u91cf\u7684\u5229\u798f\u5e73\uff0c\u63a2\u7a76\u5229\u798f\u5e73\u6d53\u5ea6\u4e0e\u751f\u957f\u901f\u7387\u3001RNA-\u86cb\u767d\u6bd4\u7387\u7684\u5173\u7cfb\u3002\u5982\u56fe4D\uff0c\u53ef\u4ee5\u770b\u5230\u751f\u957f\u901f\u7387\u968f\u7740\u5229\u798f\u5e73\u6d53\u5ea6\u7684\u589e\u52a0\u800c\u964d\u4f4e\u3002\u5728\u6838\u7cd6\u4f53\u751f\u957f\u89c4\u5f8b<\/strong>\u4e2d\uff0cRNA-\u86cb\u767d\u6bd4\u4f1a\u968f\u7740\u751f\u957f\u901f\u7387\u7684\u53d8\u52a8\u800c\u6539\u53d8\uff0c\u4f46\u5b9e\u9a8c\u4e2d\u7684RNA-\u86cb\u767d\u6bd4\u7387\u4ecd\u7136\u4fdd\u6301\u6052\u5b9a\u3002<\/span><\/section>\n

        <\/span><\/section>\n
        \u4f5c\u8005\u901a\u8fc7RNA\u805a\u5408\u9176\u751f\u957f\u89c4\u5f8b<\/strong>\u6765\u89e3\u91ca\u8be5\u5dee\u5f02\u3002\u5047\u8bbe\u5229\u798f\u5e73\u7684\u4f5c\u7528\u662f\u51cf\u5c11\u6d3b\u6027RNA\u805a\u5408\u9176\u7684\u6570\u91cf\uff0c\u5219\u5229\u798f\u5e73\u6d53\u5ea6\u589e\u52a0\uff0c\u6d3b\u6027RNA\u805a\u5408\u9176\u8d28\u91cf\u5206\u6570\u51cf\u5c11\uff0c\u56e0\u6b64RNA\u805a\u5408\u9176\u7684\u751f\u957f\u901f\u7387\u964d\u4f4e\u4e86\u3002\u6b64\u5916\uff0c\u6d3b\u6027RNA\u805a\u5408\u9176\u6570\u91cf\u7684\u51cf\u5c11\u4f1a\u964d\u4f4e\u7ec6\u80de\u4e2d\u7684\u8f6c\u5f55\u6d3b\u52a8\uff0c\u964d\u4f4e\u6240\u6709\u86cb\u767d<\/span>\uff08\u6838\u7cd6\u4f53\u6216\u975e\u6838\u7cd6\u4f53\uff09<\/span>\u7684mRNA\u6c34\u5e73\u3002\u8fd9\u5c31\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48RNA-\u86cb\u767d\u6bd4\u7387\u4f1a\u4fdd\u6301\u6052\u5b9a\u3002<\/span><\/section>\n


        <\/p>\n

        3\u3001tRNA \u81ea\u50ac\u5316\u5faa\u73af<\/span><\/strong><\/span><\/h3>\n

        <\/section>\n
        \u5728\u6240\u6709\u7684\u81ea\u50ac\u5316\u5faa\u73af\u4e2d\uff0c\u4efb\u4f55\u50ac\u5316\u5242\u90fd\u662f\u5faa\u73af\u7684\u4e00\u90e8\u5206\uff0c\u5e76\u4e14\u53ef\u4ee5\u89c6\u4e3a\u6784\u5efa\u81ea\u50ac\u5316\u5faa\u73af\u7684\u6838\u5fc3\u50ac\u5316\u5242\u3002\u4e3a\u8bc1\u660e\u8fd9\u70b9\uff0c\u4f5c\u8005\u5728\u56fe5\u5c55\u793a\u4e86\u4e24\u6761\u81ea\u50ac\u5316\u5faa\u73af\u4e2d\u7684\u751f\u957f\u89c4\u5f8b\uff1a\u6c28\u9170tRNA\u5408\u6210\u9176<\/span>\uff08aa-tRNA-synt.\uff09<\/span>\u751f\u957f\u89c4\u5f8b\u3001tRNA\u751f\u957f\u89c4\u5f8b\uff0c\u5177\u4f53\u5982\u4e0b\uff1a<\/span><\/section>\n

        <\/span><\/section>\n
          \n
        1. \n

          tRNA\u81ea\u50ac\u5316\u5faa\u73af\uff1atRNA\u88abRNA\u805a\u5408\u9176\u8f6c\u5f55\uff0c\u6210\u719f\u7684tRNA\u5728\u70ed\u4e0d\u7a33\u5b9a\u5ef6\u4f38\u56e0\u5b50<\/span>\uff08EF-Tu\uff09<\/span>\u7684\u5e2e\u52a9\u4e0b\u8fdb\u5165\u6838\u7cd6\u4f53\uff1b\u4e00\u4e9b\u88abtRNA\u8fd0\u9001\u7684\u6c28\u57fa\u9178\u6700\u7ec8\u4f1a\u5f62\u6210\u65b0\u7684RNA\u805a\u5408\u9176\uff0c\u5176\u4e2d\u4e00\u90e8\u5206\u805a\u5408\u9176\u5c06\u5bf9\u5e94tRNA\u7684\u8f6c\u5f55\uff0c\u5b8c\u6210\u6574\u4e2a\u5faa\u73af\uff0ctRNA\u751f\u957f\u89c4\u5f8b\u89c1\u56fe5A\u4e0b<\/span><\/p>\n<\/li>\n

        2. \n

          \u6c28\u9170tRNA\u5408\u6210\u9176<\/span>\uff08aaS\uff09<\/span>\u5faa\u73af\uff1a\u5728\u6c28\u9170tRNA\u5408\u6210\u9176\u50ac\u5316\u4f5c\u7528\u4e0b\uff0ctRNA\u4e0e\u6c28\u57fa\u9178\u76f8\u7ed3\u5408\uff0c\u800c\u7ed3\u5408\u540e\u7684\u4e00\u90e8\u5206tRNA\u53c2\u4e0e\u4e86\u65b0\u6c28\u9170tRNA\u5408\u6210\u9176\u7684\u5408\u6210\uff0c\u5b8c\u6210\u6574\u4e2a\u5faa\u73af\uff0c\u6c28\u9170tRNA\u5408\u6210\u9176\u751f\u957f\u89c4\u5f8b\u89c1\u56fe5B\u4e0b<\/span><\/p>\n<\/li>\n<\/ol>\n


          <\/section>\n

          <\/section>\n
          <\/section>\n
          \u56fe5. tRNA\u4e0eaaS\u81ea\u50ac\u5316\u5faa\u73af\u793a\u610f\u56fe<\/span><\/section>\n

          <\/section>\n
          \u901a\u8fc7\u7814\u7a76\u4e24\u4e2a\u5faa\u73af\uff0c\u4f5c\u8005\u53d1\u73b0\u4e86tRNA\u4e0eRNA\u805a\u5408\u9176\u7684\u6570\u91cf\u5173\u7cfb\uff0c\u5373\u7ef4\u6301\u751f\u957f\u7684\u72b6\u6001\u4e0b\uff0c\u751f\u957f\u901f\u7387\u03bc\u4e0e\u8f6c\u5f55\u6d3bRNA\u805a\u5408\u9176\u7684\u8d28\u91cf\u5206\u6570\u03b1\u3001\u8f6c\u5f55\u6301\u7eed\u65f6\u95f4\u03c4\u4ee5\u53caRNA\u805a\u5408\u9176\uff1atRNA\u6bd4\u7387\u6709\u4ee5\u4e0b\u6570\u91cf<\/strong>\u5173\u7cfb\uff1a<\/span><\/section>\n

          <\/span><\/section>\n

          <\/p>\n

          <\/span><\/section>\n

          <\/section>\n
          \u8fd9\u91cc\u7684\u6570\u91cf<\/strong>\u6307\u7684\u662ftRNA\u8fd0\u9001\u6c28\u57fa\u9178\u8fdb\u5165\u6838\u7cd6\u4f53\u8fd9\u4e00\u8fc7\u7a0b\u6240\u6d89\u53ca\u5230\u7684\u5206\u5b50\u6570\u3002\u5c3d\u7ba1RNA\u805a\u5408\u9176\u4e0etRNA\u5e76\u4e0d\u76f4\u63a5\u76f8\u5173\uff0c\u4f46RNA\u805a\u5408\u9176\u4ea7\u751f\u7684mRNA\u4f1a\u7ecf\u7531tRNA\u5b8c\u6210\u7ffb\u8bd1\u3001tRNA\u8fd0\u9001\u7684\u6c28\u57fa\u9178\u4f1a\u5408\u6210RNA\u805a\u5408\u9176\uff0c\u56e0\u6b64\u8fd9\u79cd\u6570\u91cf\u5173\u7cfb\u5728\u5e73\u8861\u589e\u957f\u7684\u6761\u4ef6\u4e0b\u662f\u6709\u610f\u4e49\u7684\u3002<\/span><\/section>\n

          <\/section>\n
           <\/span>
          <\/section>\n

          \n
          \n
          \n
          \n
          \n

          <\/section>\n

          <\/section>\n
          \n
          <\/svg><\/section>\n<\/section>\n<\/section>\n
          \n

          \u4e09\u3001\u81ea\u50ac\u5316\u751f\u957f\u89c4\u5f8b\u7684\u8fdb\u4e00\u6b65\u5e94\u7528<\/strong><\/strong><\/p>\n<\/section>\n

          \n

          <\/section>\n

          <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


          <\/p>\n

          1\u3001\u751f\u957f\u901f\u7387\u4e0e\u6e29\u5ea6\u7684\u5173\u7cfb<\/span><\/strong><\/span><\/h3>\n


          <\/span><\/strong><\/span><\/p>\n

          37\u2103\u4e0b\uff0c\u7ec6\u83cc\u7684\u751f\u957f\u89c4\u5f8b\u4e3a<\/sub><\/span><\/span>\uff08<\/span><\/sub>\u7684\u53d8\u5f62\uff09\uff0c\u4f5c\u8005\u5c06\u901a\u8fc7\u56de\u987e\u5b9e\u9a8c\u6570\u636e\u6765\u8ba8\u8bba\u751f\u957f\u901f\u7387\u4e0e\u6e29\u5ea6\u7684\u5173\u7cfb\u3002\u4f5c\u4e3a\u55dc\u6e29\u7ec6\u83cc\uff0c\u5927\u80a0\u6746\u83cc\u7684\u9002\u5b9c\u751f\u957f\u6e29\u5ea6\u572820-40\u2103\u4e4b\u95f4\u3002\u8fd9\u4e2a\u533a\u95f4\u5185\uff0c\u7ec6\u83cc\u7684RNA-\u86cb\u767d\u6bd4\u7387\u4e0d\u53d8\uff0c\u56e0\u6b64\u8d28\u91cf\u5206\u6570\u03a6\u4e5f\u4e0d\u4f1a\u53d8\u5316\u3002\u4f46\u5ef6\u4f38\u901f\u7387\u03b3\u53d7\u5230\u6e29\u5ea6\u5f71\u54cd\uff0c\u5728\u6e29\u5ea6\u53d8\u5316\u65f6\u9700\u8981\u4fee\u6b63\u3002\u4fee\u6b63\u540e\uff0c\u7ec6\u83cc\u7684\u751f\u957f\u901f\u7387\u4e0e\u6e29\u5ea6\u7684\u6570\u91cf\u5173\u7cfb\u5448\u6307\u6570\u5f0f<\/strong>\uff08\u6e29\u5ea6\u4ee5\u963f\u4f26\u5c3c\u4e4c\u5179\u5f0f<\/sub><\/span>\u7684\u56e0\u5b50\u5b58\u5728\uff09\uff0c\u8fd9\u79cd\u5173\u7cfb\u66f4\u50cf\u662f\u5728\u63cf\u8ff0\u4e00\u4e2a\u5316\u5b66\u53cd\u5e94\u3002<\/span><\/section>\n


          <\/p>\n

          <\/p>\n

          \u56fe6. \u751f\u957f\u901f\u7387\u4e0e\u6e29\u5ea6\u7684\u5173\u7cfb<\/span><\/section>\n

          <\/section>\n
          \u4e0a\u8ff0\u662f\u6b63\u5e38\u6e29\u5ea6\u4e0b\u7684\u60c5\u51b5\uff0c\u90a3\u5728\u8fd9\u4e2a\u8303\u56f4\u4e4b\u5916\u5462\uff1f\u9ad8\u6e29\u4e0b\u7684\u86cb\u767d\u53d8\u6027\uff0c\u4f4e\u6e29\u4e0b\u7684\u86cb\u767d\u6298\u53e0\u9519\u8bef\uff0c\u5747\u4f1a\u5bfc\u81f4\u7ec6\u83cc\u751f\u957f\u72b6\u6001\u5f02\u5e38\uff0c\u8fd9\u65f6\u7684\u7ec6\u83cc\u9700\u8981\u5206\u914d\u66f4\u591a\u7684\u6838\u7cd6\u4f53\uff0c\u4ee5\u5f25\u8865\u86cb\u767d\u8d28\u7684\u7f3a\u635f\u3002\u53ef\u4ee5\u5047\u8bbe\uff0c\u5728\u4e25\u7d27\u53cd\u5e94<\/span>\uff08\u7ec6\u83cc\u5904\u4e8e\u4e0d\u826f\u7684\u73af\u5883\u4e2d\u5f15\u8d77\u6c28\u57fa\u9178\u7f3a\u4e4f\u65f6\uff0c\u7ef4\u6301\u81ea\u8eab\u7684\u54cd\u5e94\u673a\u5236\uff09<\/span>\u65f6\uff0c\u6838\u7cd6\u4f53\u91cd\u65b0\u5206\u914d\u65f6\u4f1a\u503e\u5411\u4e8e\u86cb\u767d\u4ee3\u8c22\u7684\u5de5\u4f5c\uff0c\u56e0\u6b64\u5728\u8fd9\u4e9b\u533a\u95f4\u5185\u9700\u8981\u5bf9\u8d28\u91cf\u5206\u6570\u0394\u03a6\u8fdb\u884c\u4fee\u6b63\u3002\u6570\u636e\u9884\u6d4b\u7ed3\u679c\u663e\u793a<\/span>\uff08\u56fe6\uff09<\/span>\uff0c\u5927\u80a0\u6746\u83cc\u4f1a\u57288\u2103<\/span>\uff08\u4f4e\u6e29\uff09<\/span>\u4ee5\u53ca49\u2103<\/span>\uff08\u9ad8\u6e29\uff09<\/span>\u65f6\u505c\u6b62\u751f\u957f\uff0c\u4e0e\u5b9e\u9645\u6570\u636e\u76f8\u7b26\u3002<\/span><\/section>\n


          <\/p>\n

          2\u3001\u6297\u83cc\u836f\u7269\u5bf9\u5927\u80a0\u6746\u83cc\u751f\u957f\u7684\u5f71\u54cd<\/span><\/strong><\/span><\/h3>\n


          <\/p>\n

          \u62c9\u83ab\u4e09\u55ea<\/span>\uff08lamotrigine\uff09<\/span>\u662f\u4e00\u79cd\u6297\u75c9\u631b\u836f\u7269\uff0c\u8fd1\u671f\u7814\u7a76\u8868\u660e\u62c9\u83ab\u4e09\u55ea\u4f1a\u6291\u5236\u6838\u7cd6\u4f53\u7684\u88c5\u914d\uff0c\u4ece\u800c\u8d77\u5230\u6291\u83cc\u7684\u4f5c\u7528\u3002\u5b9e\u9645\u4e0a\uff0c\u62c9\u83ab\u4e09\u55ea\u662f\u5ef6\u957f\u4e86\u6838\u7cd6\u4f53\u7684\u7ec4\u88c5\u65f6\u95f4<\/strong>\uff0c\u901a\u8fc7\u6838\u7cd6\u4f53\u751f\u957f\u89c4\u5f8b\u4e0e\u7ec4\u88c5\u65f6\u95f4\u7684\u5173\u7cfb\uff0c\u53ef\u4ee5\u5f97\u51fa\u751f\u957f\u901f\u7387\u4e0e\u62c9\u83ab\u4e09\u55ea\u6d53\u5ea6\u7684\u5173\u7cfb\u3002<\/span><\/section>\n


          <\/p>\n

          \u5728\u4e0d\u5ffd\u7565\u7ec4\u88c5\u65f6\u95f4\u7684\u5047\u8bbe\u4e0b<\/span>\uff08\u7b2c\u4e8c\u90e8\u5206\u7b2c1\u5c0f\u8282\u63d0\u5230\u7684\u516c\u5f0f\uff09<\/span>\uff0c\u6c42\u89e3\u6838\u7cd6\u4f53\u751f\u957f\u89c4\u5f8b\u5f0f\u5f97\u5230\u5173\u4e8e\u751f\u957f\u901f\u7387\u03bc\u7684\u4e8c\u6b21\u65b9\u7a0b\uff0c\u5c06\u03bc\u7684\u6c42\u89e3\u5f0f\u6cf0\u52d2\u5c55\u5f00\uff0c\u5f97\uff1a<\/span><\/section>\n

          <\/span><\/section>\n
          <\/section>\n
          <\/span><\/section>\n

          <\/section>\n
          \u5c55\u5f00\u5f0f\u7684\u524d\u4e24\u9879\u8bb0\u4e3aM1\u3001M2\uff0c\u5176\u4e2dM1\u4e0e\u7ec4\u88c5\u65f6\u95f4\u65e0\u5173\uff0cM2\u4e0e\u7ec4\u88c5\u65f6\u95f4<\/span><\/sub>\u7ebf\u6027\u76f8\u5173\u3002\u5f53<\/span><\/sub><\/span>\u8fdc\u5c0f\u4e8e1\u65f6\uff0c\u7ec4\u88c5\u65f6\u95f4\u5e26\u6765\u7684\u5f71\u54cd\u53ef\u4ee5\u5ffd\u7565\u4e0d\u8ba1\uff1b\u5f53<\/span><\/sub>\u8d8b\u8fd1\u4e8e1\u65f6\uff0c\u8bf4\u660e\u56e0\u4e3a\u7ec4\u88c5\u65f6\u95f4\u7684\u589e\u52a0\uff0c\u751f\u957f\u901f\u7387\u8d8b\u8fd1\u4e8e0\u3002<\/span>
          <\/section>\n


          <\/p>\n

          \u6839\u636e\u5b9e\u9a8c\u6570\u636e\u5bf9\u6838\u7cd6\u4f53\u7ec4\u88c5\u65f6\u95f4\u8fdb\u884c\u4fee\u6b63\uff0c\u5f97\u5230\u4e86\u836f\u7269\u6d53\u5ea6\u4e0e\u751f\u957f\u901f\u7387\u7684\u5173\u7cfb\u5f0f<\/span>\uff08\u56fe7\u4e0a\uff09<\/span>\u3002\u53ef\u4ee5\u770b\u51fa\uff0c\u6781\u4f4e\u6d53\u5ea6\u4e0b\u7684\u7ec4\u88c5\u65f6\u95f4\u53ef\u5ffd\u7565\uff0c\u751f\u957f\u901f\u7387\u53d7\u5230\u7684\u5f71\u54cd\u5f88\u5c0f\uff1b\u53d7\u836f\u7269\u5f71\u54cd\uff0c\u7ec4\u88c5\u65f6\u95f4\u5ef6\u957f\uff0c\u751f\u957f\u901f\u7387\u6709\u4e86\u5f88\u660e\u663e\u7684\u964d\u4f4e\u3002<\/span><\/section>\n

          <\/span><\/section>\n
          <\/section>\n
          \u56fe7. \u6297\u83cc\u836f\u7269\u5bf9\u751f\u957f\u901f\u7387\u7684\u5f71\u54cd<\/span><\/section>\n


          <\/p>\n

          FabI \u86cb\u767d\u5728\u7ec6\u83cc\u7ec6\u80de\u819c\u7684\u8102\u80aa\u9178\u5408\u6210\u8fc7\u7a0b\u4e2d\u8d77\u5230\u4e86\u91cd\u8981\u7684\u4f5c\u7528\u3002\u9776\u5411\u8102\u80aa\u9178\u7684\u751f\u7269\u5408\u6210<\/span>\uff08\u8fc7\u7a0b\uff09<\/span>\u7684\u6297\u83cc\u836f\u7269\u4e09\u6c2f\u751f<\/span>\uff08triclosan\uff09<\/span>\uff0c\u901a\u8fc7\u6270\u4e71FabI\u86cb\u767d\u8fbe\u5230\u6291\u83cc\u7684\u4f5c\u7528<\/strong>\u3002\u8981\u7814\u7a76\u4e09\u6c2f\u751f\u7684\u5f71\u54cd\uff0c\u5c31\u9700\u8981\u5c06\u819c\u7684\u5408\u6210\u4e0e\u751f\u957f\u901f\u7387\u8054\u7cfb\u8d77\u6765\u3002<\/span><\/section>\n


          <\/p>\n

          \u50cf\u5927\u80a0\u6746\u83cc\u8fd9\u6837\u7684\u5706\u67f1\u72b6\u6746\u83cc\uff0c\u65b0\u5408\u6210\u7684\u819c\u662f\u901a\u8fc7\u63d2\u5165\u4f4d\u70b9\u63d2\u5165\u8fdb\u53bb\u7684\u3002\u5728\u5747\u8861\u589e\u957f\u7684\u60c5\u51b5\u4e0b\uff0c\u7531\u4e8e\u8f6c\u5f55-\u7ffb\u8bd1\u673a\u5668\u7684\u8026\u5408\u6027\u8d28\uff0c\u5408\u6210\u7684\u86cb\u767d\u9884\u671f\u4f1a\u5448\u6307\u6570\u589e\u957f<\/strong>\uff0c\u56e0\u6b64\u5728\u5bbd\u5ea6\u4e0d\u53d8\u7684\u60c5\u51b5\u4e0b\uff0c\u5927\u80a0\u6746\u83cc\u5ef6\u957f\u83cc\u4f53\u7684\u901f\u7387\u4e5f\u5c06\u662f\u6307\u6570\u7684<\/strong>\u3002<\/span><\/section>\n


          <\/p>\n

          \u901a\u8fc7\u63a8\u5bfc\u76f8\u5173\u4e30\u5ea6\u7684\u589e\u957f\u89c4\u5f8b\uff0c\u4f5c\u8005\u5f97\u5230\u4e86\u819c\u5408\u6210\u4e0e\u751f\u957f\u901f\u7387\u7684\u6570\u5b66\u5173\u7cfb\uff1a<\/span><\/sub>\u3002\u6839\u636e\u5b9e\u9a8c\u6570\u636e\u5bf9\u65b0\u819c\u5d4c\u5165\u901f\u7387<\/sub>\u8fdb\u884c\u62df\u5408\u4fee\u6b63\uff0c\u5f97\u5230\u836f\u7269\u4e09\u6c2f\u751f\u7684\u6d53\u5ea6\u4e0e\u751f\u957f\u901f\u7387\u7684\u5173\u7cfb\u5f0f<\/span>\uff08\u56fe7\u4e0b\uff09<\/span>\u3002\u53ef\u4ee5\u770b\u51fa\uff0c\u53d7\u5230\u4e09\u6c2f\u751f\u7684\u5f71\u54cd\uff0c\u8102\u80aa\u9178\u4f9b\u5e94\u4e0d\u8db3\u5bfc\u81f4\u65b0\u819c\u5d4c\u5165\u901f\u7387\u964d\u4f4e\uff0c\u751f\u957f\u901f\u7387\u968f\u4e4b\u53d7\u5230\u5f71\u54cd\u3002<\/span><\/section>\n
           <\/span>
          <\/section>\n

          <\/span><\/section>\n

          \n
          \n
          \n
          \n
          \n

          <\/section>\n

          <\/section>\n
          \n
          <\/svg><\/section>\n<\/section>\n<\/section>\n
          \n

          \u56db\u3001\u8ba8\u8bba\u5ef6\u4f38<\/strong><\/strong><\/p>\n<\/section>\n

          \n

          <\/section>\n

          <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n

          <\/section>\n
          \u8f6c\u5f55\u3001\u7ffb\u8bd1\u3001\u65b0\u9648\u4ee3\u8c22\u3001\u819c\u5408\u6210\uff0c\u7ec6\u80de\u7684\u8bf8\u591a\u751f\u5316\u8fc7\u7a0b\u4e0e\u7ec6\u80de\u751f\u957f\u901f\u7387\u4e4b\u95f4\u7684\u8054\u7cfb\uff0c\u5747\u53ef\u901a\u8fc7\u7b80\u5355\u7684\u6570\u5b66\u5173\u7cfb\u2014\u2014\u7ec6\u83cc\u751f\u957f\u89c4\u5f8b\u6765\u63cf\u8ff0\uff0c\u4f46\u8fd9\u5e76\u4e0d\u7b49\u540c\u4e8e\uff0c\u7406\u89e3\u751f\u5316\u8fc7\u7a0b\u4e0e\u751f\u957f\u901f\u7387\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb<\/strong>\u662f\u4ef6\u6613\u4e8b\u3002\u4ece\u81ea\u50ac\u5316\u5faa\u73af\u5f97\u5230\u751f\u957f\u89c4\u5f8b\uff0c\u9700\u8981\u5c40\u90e8\u5c42\u9762\u4e0a\u5bf9\u5faa\u73af\u5185\u50ac\u5316\u5242\u7684\u65f6\u95f4\u5c3a\u5ea6\u6709\u6240\u4e86\u89e3\uff0c\u4e5f\u9700\u8981\u5b8f\u89c2\u5c42\u9762\u4e0a\u638c\u63e1\u5404\u79cd\u50ac\u5316\u5242\u7684\u5206\u914d\u53c2\u6570\u3002<\/span>\u8981\u7406\u89e3\u53d8\u91cf\u4e0e\u751f\u957f\u901f\u7387\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u5c31\u9700\u8981\u5bf9\u5206\u914d\u7cfb\u6570\u7684\u786e\u5b9a\u6709\u5168\u5c40\u7684\u7406\u89e3\u3002<\/span>\u800c\u8fd9\u5c31\u9700\u8981\u77e5\u9053\u5728\u5404\u4e2a\u81ea\u50ac\u5316\u5faa\u73af\u4e4b\u95f4\uff0c\u7ec6\u80de\u662f\u5982\u4f55\u5206\u914d\u3001\u8c03\u63a7\u8d44\u6e90\u7684\uff0c\u4ee5\u53ca\u8fd9\u4e9b\u662f\u5982\u4f55\u5728\u8fdb\u5316\u4e4b\u4e2d\u786e\u5b9a\u4e0b\u6765\u7684\u3002<\/span><\/section>\n


          <\/p>\n

          \u9000\u4e00\u6b65\u8bb2\uff0c\u8f83\u65e9\u53d1\u73b0\u7684\u6838\u7cd6\u4f53\u751f\u957f\u89c4\u5f8b\u540c\u6837\u4e0d\u80fd\u63d0\u4f9b\u56e0\u679c\u89e3\u91ca\u3002\u5f53\u73af\u5883\u4e2d\u7684\u8425\u517b\u6210\u5206\u6539\u53d8\u65f6\uff0c\u5728\u51e0\u4e2a\u8026\u5408\u7684\u81ea\u50ac\u5316\u5faa\u73af\u4e2d\uff0c\u7ec6\u80de\u662f\u5982\u4f55\u5168\u5c40\u8c03\u63a7\u3001\u6539\u53d8\u6838\u7cd6\u4f53\u8d28\u91cf\u5206\u6570\u3001\u6539\u53d8\u5ef6\u4f38\u901f\u7387\u7684\uff0c\u8fd9\u4e5f\u9700\u8981\u5408\u9002\u7684\u56e0\u679c\u6a21\u578b\u53bb\u89e3\u91ca\u3002\u5426\u5219\uff0c\u6211\u4eec\u96be\u4ee5\u5206\u8fa8\u540c\u4e00\u4e2a\u751f\u957f\u901f\u7387\u80cc\u540e\u4e0d\u540c\u7684\u673a\u5236\u3002<\/span><\/section>\n


          <\/p>\n

          \u7814\u7a76\u8005\u901a\u8fc7\u53d1\u73b0\u8fd9\u4e9b\u4ea4\u7ec7\u5728\u4e00\u8d77\u7684\u751f\u7406\u8fc7\u7a0b\u4e2d\u7684\u50ac\u5316\u5242<\/strong>\uff0c\u5efa\u7acb\u4ee5\u50ac\u5316\u5242\u4e3a\u6838\u5fc3\u7684\u81ea\u50ac\u5316\u5faa\u73af\uff0c\u5e76\u901a\u8fc7\u5904\u4e8e\u6838\u5fc3\u5730\u4f4d\u7684\u751f\u5316\u8fc7\u7a0b\u2014\u2014\u8f6c\u5f55-\u7ffb\u8bd1<\/strong>\u5c06\u5176\u8026\u5408\u8d77\u6765\uff0c\u5f62\u6210\u7ec6\u83cc\u7ec6\u80de\u5185\u7edf\u4e00\u7684\u81ea\u50ac\u5316\u7f51\u7edc\u3002\u901a\u8fc7\u5bf9\u751f\u5316\u8fc7\u7a0b\u7684\u7406\u89e3\uff0c\u5bf9\u4e8e\u8be5\u7f51\u7edc\uff0c\u7814\u7a76\u8005\u57fa\u4e8e\u4e00\u4e9b\u53c2\u6570\u7684\u7701\u7565\u4e0e\u5047\u8bbe\uff0c\u53d1\u73b0\u4e86\u8f83\u591a\u7684\u751f\u957f\u89c4\u5f8b\u3002\u901a\u8fc7\u7b80\u5355\u7684\u5173\u7cfb\u5f0f\u63cf\u8ff0\u7ec6\u83cc\u751f\u7406\u8fc7\u7a0b\uff0c\u8fd9\u662f\u201c\u7269\u7406\u7684\u201d\uff1b\u800c\u8fd9\u80cc\u540e\u5404\u4e2a\u751f\u7406\u673a\u5236\u4e4b\u95f4\u7684\u590d\u6742\u5173\u7cfb\uff0c\u53c8\u662f\u201c\u751f\u7269\u7684\u201d<\/strong>\u3002\u901a\u8fc7\u4e00\u4e9b\u53c2\u6570\u7684\u53d6\u820d\uff0c\u7814\u7a76\u8005\u5728\u5145\u6ee1\u77db\u76fe\u6027\u7684\u4e8c\u8005\u4e4b\u95f4\u8fbe\u6210\u4e86\u5fae\u5f31\u7684\u5e73\u8861\uff1a\u4e00\u65b9\u9762\uff0c\u8fd9\u4e9b\u751f\u957f\u89c4\u5f8b\u7b80\u5355\u800c\u6709\u6548\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u751f\u957f\u89c4\u5f8b\u7684\u6709\u6548\u6027\u4e0d\u80fd\u5b8c\u5168\u89e3\u91ca\u7ec6\u80de\u7684\u751f\u7406\u72b6\u6001\u3002<\/span><\/section>\n


          <\/p>\n

          \u7ec6\u80de\u5982\u4f55\u54cd\u5e94\u5185\u5916\u73af\u5883\u53d8\u5316\uff1f\u5982\u4f55\u638c\u63e1\u8bf8\u591a\u8c03\u6574\u65b9\u6848\u4ee5\u5e94\u5bf9\u8fdb\u5316\u7684\u538b\u529b\uff1f\u6211\u4eec\u8be5\u5982\u4f55\u5bf9\u751f\u5316\u8fc7\u7a0b\u4e0e\u751f\u957f\u901f\u7387\u8fdb\u884c\u56e0\u679c\u89e3\u91ca\uff1f\u7406\u89e3\u548c\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\u90fd\u662f\u4e0d\u5c0f\u7684\u6311\u6218\u3002<\/span><\/section>\n


          <\/p>\n


          <\/p>\n

          \u53c2\u8003\u6587\u732e<\/strong><\/span><\/section>\n

          [1]. Scott M, Hwa T. Bacterial growth laws and their applications. Curr Opin Biotechnol. 2011 Aug;22(4):559-65. doi: 10.1016\/j.copbio.2011.04.014. Epub 2011 May 16. PMID: 21592775; PMCID: PMC3152618.<\/span><\/p>\n


          <\/section>\n

          <\/section>\n
          \n
          \n
          \n
          \n

          \u81ea\u751f\u6210\u7ed3\u6784\u8bfb\u4e66\u4f1a\u62a5\u540d\u4e2d<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


          <\/p>\n

          \u751f\u547d\u662f\u6709\u5fc3\uff08\u610f\u8bc6\uff09\u7684\uff0c\u4f46\u5f53\u4f60\u4e00\u5c42\u5c42\u5265\u5f00\u751f\u547d\u7684\u7ec4\u7ec7\uff0c\u5374\u53ea\u6709\u5fc3\u810f\u800c\u6ca1\u6709\u4e00\u9897\u201c\u5fc3\u7075\u201d\uff1b\u6253\u5f00\u5927\u8111\u76ae\u5c42\u770b\u5230\u4e00\u4e2a\u4e2a\u795e\u7ecf\u5143\uff0c\u5374\u770b\u4e0d\u5230\u201c\u610f\u8bc6\u201d\u3002\u7136\u800c\uff0c\u751f\u547d\u4e0e\u610f\u8bc6\u90fd\u5177\u6709”\u81ea\u6211\u751f\u6210”\u7684\u80fd\u529b\uff0c\u751f\u547d\u81ea\u53d1\u4ece\u975e\u751f\u547d\u4e2d\u751f\u6210\uff0c\u610f\u8bc6\u81ea\u53d1\u4ece\u751f\u547d\u4e2d\u751f\u6210\u3002\u66f4\u60ca\u4eba\u7684\u662f\uff0c\u751f\u547d\u4e0e\u610f\u8bc6\u7684\u81ea\u6211\u751f\u6210\u7ed3\u6784\u4f3c\u4e4e\u5f88\u76f8\u4f3c\u3002\u5982\u679c\u8fd9\u4e2a\u5047\u8bbe\u6210\u7acb\uff0c\u90a3\u4e48\u6700\u53ef\u80fd\u7684\u5907\u9009\u7ed3\u6784\u4f1a\u662f\u4ec0\u4e48\u5462\uff1f<\/span><\/p>\n


          <\/p>\n

          \u4e3a\u4e86\u66f4\u6df1\u5165\u5730\u8ba4\u8bc6\u590d\u6742\u6d3b\u7cfb\u7edf\u7684\u81ea\u751f\u6210\u7ed3\u6784\uff0c\u96c6\u667a\u79d1\u5b66\u5bb6\u5c0f\u6728\u7403(\u4ec7\u73ae\u794e)\u8054\u5408\u5468\u7406\u4e7e\u3001\u738b\u4e1c\u3001\u8463\u8fbe\u3001\u5218\u5b87\u3001\u82d1\u660e\u7406\u3001\u5085\u6e25\u6210\u3001\u7ae0\u5f66\u535a\u7b49\u79d1\u5b66\u54f2\u5b66\u3001\u8ba1\u7b97\u673a\u79d1\u5b66\u3001\u7269\u7406\u5b66\u548c\u751f\u7269\u5316\u5b66\u7b49\u5b66\u79d1\u7684\u4e00\u7ebf\u7814\u7a76\u8005\u5171\u540c\u53d1\u8d77\u7ec4\u7ec7\u300a\u81ea\u751f\u6210\u7ed3\u6784\u7cfb\u5217\u8bfb\u4e66\u4f1a\u300b\u3002\u5176\u4e2d\u7b2c\u4e00\u5b63\u300a\u5171\u8bc6\u2014\u2014\u81ea\u751f\u6210\u7ed3\u6784\u4e0e\u81ea\u590d\u5236\u81ea\u52a8\u673a\u7684\u7814\u7a76\u80cc\u666f\u300b<\/a>\uff0c\u5c06\u81ea2021\u5e7411\u670820\u65e5\u5f00\u59cb\uff0c\u5176\u540e\u62df\u4e8e\u6bcf\u5468\u4e94\u665a19:00-21:00\u7ebf\u4e0a\u4e3e\u884c\uff0c\u9884\u8ba1\u6301\u7eed12\u5468\u3002\u6b22\u8fce\u4ece\u4e8b\u76f8\u5173\u7814\u7a76\u3001\u5bf9\u76f8\u5173\u9886\u57df\u6709\u6d53\u539a\u5174\u8da3\u7684\u63a2\u7d22\u8005\u62a5\u540d\u53c2\u4e0e\u4ea4\u6d41\u3002<\/span><\/p>\n


          <\/p>\n

          <\/span><\/a><\/p>\n


          <\/section>\n
          \u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/section>\n
          \u81ea\u751f\u6210\u7ed3\u6784\u8bfb\u4e66\u4f1a\u542f\u52a8\uff1a\u5256\u89e3\u751f\u547d\u3001\u610f\u8bc6\u4e0e\u667a\u80fd\u7684\u6838\u5fc3\u7ed3\u6784<\/a><\/span>
          <\/section>\n


          <\/p>\n


          <\/span><\/section>\n
          \n

          \u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n