{"id":29850,"date":"2021-11-08T21:00:01","date_gmt":"2021-11-08T13:00:01","guid":{"rendered":"https:\/\/swarma.org\/?p=29850"},"modified":"2021-11-08T21:00:01","modified_gmt":"2021-11-08T13:00:01","slug":"%e7%94%9f%e5%91%bd%e5%a6%82%e4%bd%95%e5%9c%a8%e5%a4%8d%e6%9d%82%e7%8e%af%e5%a2%83%e4%b8%ad%e7%94%9f%e5%ad%98%ef%bc%9f%e4%bf%a1%e6%81%af%e3%80%81%e8%b0%83%e6%8e%a7%e5%92%8c%e5%87%a0%e4%bd%95%e7%bb%93","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=29850","title":{"rendered":"\u751f\u547d\u5982\u4f55\u5728\u590d\u6742\u73af\u5883\u4e2d\u751f\u5b58\uff1f\u4fe1\u606f\u3001\u8c03\u63a7\u548c\u51e0\u4f55\u7ed3\u6784\u7684\u4ea4\u7ec7"},"content":{"rendered":"
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Biology, geometry and information<\/span><\/p>\n

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https:\/\/link.springer.com\/article\/10.1007\/s12064-021-00351-9<\/p>\n

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\u672c\u6587\u662f\u6211\u5728\u300c\u751f\u547d\u7684\u51e0\u4f55\u4e0e\u73b0\u8c61\u5b66\u2014\u2014\u6570\u5b66\u5316\u3001\u590d\u6742\u6027\u4e0e\u4e2a\u4f53\u5316\u7684\u5c40\u9650\u6027\u548c\u53ef\u80fd\u6027\u300d \u4f1a\u8bae\u4e0a\u53d1\u8a00\u7684\u6269\u5c55\u7248\u672c\u3002\u6211\u611f\u8c22 Luciano Boi\u3001Carlos Lobo \u548c Giuseppe Longo \u7ec4\u7ec7\u4e86\u4e00\u6b21\u975e\u5e38\u5177\u6709\u542f\u53d1\u6027\u7684\u4f1a\u8bae\u3002\u6b64\u5916\u6211\u8fd8\u611f\u8c22\u4e0e Klaus Scherrer \u5728\u5206\u5b50\u751f\u7269\u5b66\u6982\u5ff5\u57fa\u7840\u4e0a\u8fdb\u884c\u7684\u9f13\u821e\u4eba\u5fc3\u7684\u5408\u4f5c\uff0c\u4ee5\u53ca\u548c Manfred Laubichler \u7b49\u5176\u4ed6\u8bb8\u591a\u4eba\u6fc0\u52a8\u4eba\u5fc3\u7684\u8ba8\u8bba\u3002<\/span><\/section>\n

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 <\/span>
<\/section>\n

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<\/svg><\/section>\n<\/section>\n<\/section>\n
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\u751f\u7269\u5b66\u548c\u6570\u5b66<\/strong><\/strong><\/p>\n<\/section>\n

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<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u51e0\u4f55\u5b66\u3001\u4fe1\u606f\u5b66\u3001\u52a8\u529b\u5b66\u7b49\uff0c\u8fd9\u4e9b\u5bfc\u8bba\u4e2d\u51fa\u73b0\u7684\u57fa\u672c\u6982\u5ff5\uff0c\u90fd\u662f\u6570\u5b66\u6982\u5ff5\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u5c06\u7cfb\u7edf\u5730\u5229\u7528\u6570\u5b66\u601d\u60f3\u3002\u4e3a\u4e86\u8bf4\u660e\u8fd9\u4e00\u70b9\uff0c\u6211\u4eec\u9700\u8981\u9996\u5148\u8ba8\u8bba\u4e00\u4e2a\u57fa\u672c\u95ee\u9898\uff1a\u6570\u5b66\u80fd\u5bf9\u751f\u7269\u5b66\u505a\u51fa\u4ec0\u4e48\u8d21\u732e\u3002\u4e00\u822c\u7684\u8bf4\u6cd5\u53ef\u80fd\u662f\uff1a<\/span><\/section>\n
 <\/span><\/section>\n
    \n
  • \n

    \u68c0\u6d4b\u6570\u636e\u7ed3\u6784\u7684\u65b9\u6cd5\uff1b<\/p>\n<\/li>\n

  • \n

    \u751f\u7269\u7269\u7406\u8fc7\u7a0b\u7684\u52a8\u529b\u5b66\u6a21\u578b\u53ca\u5206\u6790\uff1b<\/p>\n<\/li>\n

  • \n
    \u62bd\u8c61\u6982\u5ff5\u5206\u6790\u3002<\/section>\n<\/li>\n<\/ul>\n
     <\/span><\/section>\n
    \u663e\u7136\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u5728\u975e\u5e38\u4e0d\u540c\u7684\u5c42\u6b21\u4e0a\u8fd0\u4f5c\u3002\u56e0\u6b64\uff0c\u8ba9\u6211\u4eec\u66f4\u8be6\u7ec6\u8003\u8651\u4e00\u4e9b\u53ef\u80fd\u7684\u6570\u5b66\u65b9\u6cd5\u3002\u7136\u540e\u6211\u4eec\u5c06\u770b\u5230\uff0c\u5728\u67d0\u79cd\u610f\u4e49\u4e0a\uff0c\u5b83\u4eec\u8d2f\u7a7f\u4e86\u524d\u9762\u5217\u8868\u7684\u6240\u6709\u4e0d\u540c\u5c42\u6b21\uff1a<\/span><\/section>\n
     <\/span><\/section>\n
      \n
    1. \n
      \u4fe1\u606f\u8bba\uff1a<\/span><\/strong>\u5728\u8fd9\u91cc\uff0c\u751f\u7269\u7684\u57fa\u672c\u95ee\u9898\u53d8\u6210\u4e86\u300c\u4ec0\u4e48\u4fe1\u606f\u662f\u76f8\u5173\u7684\u300d\u3002\u5373\uff0c\u8fd9\u79cd\u4fe1\u606f\u53ea\u6709\u5728\u4e0e\u6240\u6d89\u53ca\u751f\u7269\u5b9e\u4f53\u76f8\u5173\u7684\u60c5\u51b5\u4e0b\uff0c\u901a\u8fc7\u6307\u5f15\u751f\u7269\u751f\u5b58\u3001\u7ef4\u6301\u6216\u7e41\u6b96\uff0c\u624d\u80fd\u83b7\u5f97\u5176\u4ef7\u503c\u3002<\/span><\/section>\n<\/li>\n
    2. \n
      \uff08\u4e09\u7ef4\uff09\u51e0\u4f55\u5b66\uff1a<\/span><\/strong>\u751f\u7269\u53d1\u751f\u5728\u4e09\u7ef4\u7a7a\u95f4\u91cc\u8fd9\u4e00\u4e8b\u5b9e\u5f88\u91cd\u8981\uff0c\u4f46\u5728\u7406\u8bba\u751f\u7269\u5b66\u4e2d\u5f80\u5f80\u6839\u672c\u6ca1\u6709\u6d89\u53ca\u3002\u4e0d\u8fc7\uff0c\u5728 Bailly \u548c Longo<\/span>\uff082011\uff09<\/span>\u5de5\u4f5c\u4e2d\uff0c\u8fd9\u70b9\u88ab\u6e05\u695a\u63ed\u793a\u548c\u63a2\u8ba8\u4e86\u3002\u4e09\u7ef4\u7a7a\u95f4\u80fd\u591f\u540c\u65f6\u4fc3\u8fdb\u548c\u7ea6\u675f\u751f\u7269\u8fc7\u7a0b\u3002\u8f83\u5c11\u7684\u7ef4\u5ea6\u63d0\u4f9b\u7684\u7a7a\u95f4\u6392\u5217\u6216\u76f8\u4e92\u4f5c\u7528\u53ef\u80fd\u6027\u592a\u5c11\uff0c\u4f46\u8f83\u591a\u7684\u7ef4\u5ea6\u53c8\u53ef\u80fd\u4e0d\u8db3\u4ee5\u7ea6\u675f\u751f\u7269\u8fc7\u7a0b\u4ee5\u9632\u6b62\u5b83\u4eec\u74e6\u89e3\u3002<\/span><\/section>\n<\/li>\n
    3. \n
      \u751f\u7269\u7269\u7406\u6a21\u578b\u548c\u52a8\u529b\u7cfb\u7edf<\/span><\/strong>\u3002\u8fd9\u91cc\uff0c\u4e00\u4e2a\u91cd\u8981\u7684\u95ee\u9898\u662f\u5173\u4e8e\u751f\u7269\u6a21\u578b\u7684\u9002\u5f53\u8be6\u7ec6\u5ea6\u3002\u4e8b\u5b9e\u4e0a\uff0c\u66f4\u8be6\u7ec6\u7684\u6a21\u578b\u6709\u65f6\u4f1a\u6bd4\u66f4\u7c97\u7cd9\u7684\u6a21\u578b\u4ea7\u751f\u66f4\u4e0d\u51c6\u786e\u6216\u5177\u9c81\u68d2\u6027\u7684\u9884\u6d4b\u3002\u5176\u4e2d\u6709\u4e9b\u60c5\u51b5\u53ef\u80fd\u53ea\u662f\u8fc7\u62df\u5408\uff0c\u4f46\u66f4\u6df1\u5c42\u6b21\u7684\u539f\u56e0\u8fd8\u6ca1\u6709\u4ece\u751f\u7269\u5b66\u89d2\u5ea6\u88ab\u7cfb\u7edf\u5730\u7406\u89e3\u3002<\/span><\/section>\n<\/li>\n
    4. \n

      \u7f51\u7edc\u5206\u6790\u53ca\u62d3\u5c55\uff0c\u5982\u5355\u7eaf\u590d\u5f62\u6216\u8d85\u56fe<\/span><\/strong>\uff08simplicial complexes or hypergraphs\uff09<\/span>\u3002\u5728\u8fd9\u91cc\uff0c\u751f\u7269\u7f51\u7edc\u548c\u5176\u5b83\u7f51\u7edc\u5206\u6790\u4e2d\u4e00\u4e2a\u88ab\u666e\u904d\u5ffd\u7565\u7684\u91cd\u70b9\u662f\u8fb9\u8868\u793a\u5173\u7cfb\uff0c\u800c\u975e\u9876\u70b9\uff0c\u5e94\u8be5\u6210\u4e3a\u7f51\u7edc\u5206\u6790\u7684\u57fa\u672c\u5bf9\u8c61\u3002\u7279\u522b\u662f\uff0c\u7f51\u7edc\u5206\u6790\u4e2d\u4f7f\u7528\u7684\u91cf\u5e94\u8be5\u7ed9\u8fb9\u8d4b\u503c\uff0c\u800c\u975e\u7ed9\u9876\u70b9\u8d4b\u503c\u3002<\/span><\/p>\n<\/li>\n<\/ol>\n

       <\/span><\/section>\n
       <\/span>
      <\/section>\n

      \n
      \n
      \n
      \n
      \n

      <\/section>\n

      <\/section>\n
      \n
      <\/svg><\/section>\n<\/section>\n<\/section>\n
      \n

      \u4e09\u7ef4\u51e0\u4f55\u5b66<\/strong><\/strong><\/p>\n<\/section>\n

      \n

      <\/section>\n

      <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


      <\/p>\n

      \u751f\u7269\u7ed3\u6784\u5728\u7a7a\u95f4\u4e2d\u5b58\u5728\u5e76\u53d1\u751f\u76f8\u4e92\u4f5c\u7528\u3002\u7a7a\u95f4\u662f\u4e09\u7ef4\u7684\uff0c\u5c3d\u7ba1\u4ece\u751f\u7269\u4f53\u89d2\u5ea6\u6765\u770b\u5e76\u975e\u6b27\u51e0\u91cc\u5f97\u5f0f\uff0c\u4e14\u7531\u4e8e\u91cd\u529b\u5728\u5730\u7403\u8868\u9762\u53ea\u4f5c\u7528\u5728\u4e00\u4e2a\u65b9\u5411\uff0c\u56e0\u6b64\u9646\u5730\u751f\u7269\u7684\u673a\u52a8\u6027<\/span>\uff08mobility\uff09<\/span>\u548c\u4ea4\u4e92\u7a0b\u5ea6\u5f80\u5f80\u88ab\u9650\u5236\u5728\u66f4\u50cf\u4e8c\u7ef4\u4e0a\u3002\u4f46\u5728\u7ec6\u80de\u5c3a\u5ea6\u4e0a\uff0c\u5b83\u7684\u4f5c\u7528\u5c31\u53d8\u5c0f\u4e86\u3002\u4e0d\u7ba1\u600e\u6837\uff0c\u751f\u547d\u6700\u91cd\u8981\u7684\u7ed3\u6784\u4e4b\u4e00 DNA\uff0c\u662f\u4ee5\u4e00\u7ef4\u65b9\u5f0f\u6392\u5217\u7684\u3002<\/span><\/section>\n

      <\/span><\/section>\n
      \u4f55\u4ee5\u5982\u6b64\uff1f\u5e76\u975e\u4e09\u7ef4\u6545\uff0c\u56e0\u4e09\u7ef4\u7269\u4f53\u5185\u90e8\u4e0d\u80fd\u76f4\u63a5\u8bfb\u53d6\u6216\u590d\u5236\uff1b\u975e\u4e8c\u7ef4\u6545\uff0c\u662f\u56e0\u7ebf\u6027\u7ed3\u6784\u66f4\u9002\u5408\u987a\u5e8f\u3001\u65f6\u95f4\u4e0a\u7684\u5904\u7406<\/span><\/strong>\u3002\u53cd\u800c\u7531\u4e8e\u6709\u7ec4\u88c5\u591a\u80bd\u7684\u6838\u7cd6\u4f53\u90a3\u6837\u7684\u74f6\u9888\u4f1a\u9700\u8981\u4e00\u7ef4\u3002\u540c\u7406\uff0c\u5f53\u590d\u5236\u4ee5\u987a\u5e8f\u3001\u65f6\u5e8f\u5f0f\u8fdb\u884c\u65f6\uff0c\u4f3c\u4e4e\u66f4\u4e0d\u5bb9\u6613\u51fa\u9519\uff0c\u800c\u4e14\u66f4\u8282\u80fd\uff0c\u4e0d\u50cf\u5728\u590d\u5370\u673a\u4e2d\u540c\u65f6\u5904\u7406\u90a3\u6837\u3002\u6b64\u5916\uff0c\u5f53\u590d\u5236\u6309\u987a\u5e8f\u8fdb\u884c\u65f6\uff0c\u76f8\u540c\u7684\u590d\u5236\u5206\u5b50\u548c\u7ed3\u6784\u53ef\u4ee5\u88ab\u91cd\u590d\u4f7f\u7528\u3002\u5f53\u7136\uff0c\u65e0\u8bbaDNA\u672c\u8eab\u8fd8\u662f\u5176\u4ea7\u7269\uff0c\u8fd9\u4e9b\u591a\u80bd\u90fd\u4f1a\u5177\u6709\u67d0\u79cd\u4e09\u7ef4\u5f62\u6001\u3002\u5bf9\u6784\u6210\u86cb\u767d\u8d28\u7684\u591a\u80bd\u6765\u8bf4\uff0c\u8fd9\u5bf9\u5b83\u4eec\u7684\u751f\u7269\u529f\u80fd\u81f3\u5173\u91cd\u8981\uff0c\u901a\u8fc7\u8fd9\u79cd\u65b9\u5f0f\uff0c\u7279\u5b9a\u7684\u610f\u56fe\u5f97\u4ee5\u8868\u8fbe\u5728\u4e0e\u5176\u5b83\u7269\u8d28\u7684\u76f8\u4e92\u4f5c\u7528\u4e2d\uff0c\u6216\u53cd\u4e4b\u5c4f\u853d\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528\u3002\u5bf9DNA\u6765\u8bf4\uff0c\u6b63\u5982 Boi<\/span> (2011) <\/span>\u6240\u5f3a\u8c03\u7684\u90a3\u6837\uff0c\u7a7a\u95f4\u6392\u5217\u5bf9\u4e8e\u57fa\u56e0\u8f6c\u5f55\u7684\u8c03\u63a7\u81f3\u5173\u91cd\u8981\u3002\u4f8b\u5982\uff0c\u901a\u8fc7\u9002\u5f53\u7684\u7a7a\u95f4\u7ec4\u7ec7\uff0c\u5e94\u540c\u65f6\u8f6c\u5f55\u7684\u57fa\u56e0\u7ec4\u533a\uff0c\u5373\u4f7f\u5728DNA\u4e0a\u7684\u5185\u5728\u7ebf\u6027\u8ddd\u79bb\u5f88\u5927\uff0c\u4e5f\u80fd\u88ab\u5e26\u5165\u5230\u76f8\u90bb\u7a7a\u95f4\u4e2d\uff0c\u4ece\u800c\u4fc3\u4f7f\u5171\u540c\u8c03\u8282\u3002\u8fd9\u6b63\u5982 K\u00e9p\u00e8s \u548c Vaillant<\/span> (2003\uff09<\/span>\u6240\u63d0\u51fa\u7684\uff0c\u867d\u7136\u4ed6\u4eec\u4e00\u5f00\u59cb\u7684\u87ba\u7ebf\u7ba1\u6a21\u578b\u53ef\u80fd\u8fc7\u4e8e\u7b80\u5355\u3002DNA\u7684\u7a7a\u95f4\u7ec4\u7ec7\u80af\u5b9a\u4e0d\u662f\u4e00\u773c\u671b\u53bb\u90a3\u6837\u65e0\u89c4\u5f8b\uff0c\u4e5f\u4e0d\u50cf\u7b2c\u4e00\u4e2a\u63d0\u51fa\u7684\u6a21\u578b\u4e2d\u90a3\u4e48\u6709\u89c4\u5f8b\uff0c\u800c\u662f\u80af\u5b9a\u7531\u7279\u5b9a\u7684\u86cb\u767d\u8d28\u975e\u5e38\u5468\u5bc6\u5730\u7ec4\u7ec7\u8d77\u6765\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \u5bf9RNA\u6765\u8bf4\uff0c\u5b83\u4e0d\u4ec5\u662fDNA\u548c\u86cb\u767d\u8d28\u7684\u4e2d\u95f4\u4ea7\u7269\uff0c\u4e5f\u662f\u8c03\u8282\u548c\u5904\u7406\u7684\u5173\u952e\u5b9e\u4f8b<\/span>\uff08\u5305\u62ec\u4e00\u7cfb\u5217\u50ac\u5316\u4f5c\u7528\uff09<\/span>\uff0c\u7b2c\u4e8c\u79cd\u6784\u9020\u5f88\u91cd\u8981\uff0c\u901a\u8fc7\u7ebf\u6027\u5e8f\u5217\u4e2d\u4e92\u8865\u7684\u6838\u82f7\u9178\u5bf9\u7684\u952e\u5f97\u4ee5\u5b9e\u73b0\u3002\u5176\u4e2d\u5927\u90e8\u5206\u52a0\u5de5\u8fc7\u7a0b\u662f\u901a\u8fc7\u4e0e\u7279\u5b9a\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u6765\u8c03\u8282\u7684\uff0c\u5728 Jost \u548c Scherrer<\/span>\uff082014\uff09<\/span>\u4e2d\uff0c\u5df2\u7ecf\u63d0\u51fa\u4e86\u4e00\u79cd\u7ec4\u5408\u7f16\u7801\u65b9\u5f0f\u3002\u53cd\u8fc7\u6765\uff0cRNA\u5206\u5b50\u4e5f\u53ef\u4ee5\u5145\u5f53\u811a\u624b\u67b6\u7684\u89d2\u8272\uff0c\u5c06\u7279\u5b9a\u7684\u86cb\u767d\u8d28\u7ec4\u805a\u5728\u4e00\u8d77\uff0c\u8bf1\u5bfc\u5b83\u4eec\u53d1\u751f\u529f\u80fd\u4e92\u52a8\u3002\u800c\u5bf9\u8fd9\u79cd\u4f5c\u7528\uff0c\u4e8c\u7ef4\u7ed3\u6784\u4f3c\u4e4e\u6700\u5408\u9002\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \u56e0\u6b64\uff0c\u4e00\u5e45\u6f2b\u753b\u53ef\u80fd\u4f1a\u753b\u7740\u8bf4\uff1a\u6211\u4eec\u662f\u4ece\u4e00\u7ef4\u7684DNA<\/span>\uff08\u4fe1\u606f\u5b58\u50a8\uff09<\/span>\uff0c\u901a\u8fc7\u4e8c\u7ef4\u7684RNA<\/span>\uff08\u8c03\u8282\u548c\u5904\u7406\uff09<\/span>\uff0c\u53d8\u6210\u4e86\u4e09\u7ef4\u7684\u86cb\u767d\u8d28\u7ec4<\/span>\uff08\u7ec6\u80de\u529f\u80fd\uff09<\/span>\uff01\u5f53\u7136\uff0c\u6b63\u5982\u4e0a\u8ff0\u8ba8\u8bba\uff0cDNA\u4e5f\u662f\u4ee5\u4e09\u7ef4\u65b9\u5f0f\u7ec4\u7ec7\u7684\uff0cRNA\u548c\u86cb\u767d\u8d28\u5219\u4e0d\u4ec5\u6709\u4e09\u7ef4\u5f62\u4f53\uff0c\u8fd8\u4ee5\u4e09\u7ef4\u65b9\u5f0f\u4ea4\u4e92\u4f5c\u7528\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \u540e\u4e00\u70b9\u8868\u660e\uff0c\u4e09\u7ef4\u51e0\u4f55\u4e0d\u4ec5\u5bf9\u5982\u86cb\u767d\u8d28\u6216DNA\u8fd9\u6837\u7684\u5355\u4e00\u7ed3\u6784\uff0c\u5bf9\u7ed3\u6784\u4e4b\u95f4\u7684\u4f5c\u7528\u4e5f\u5f88\u91cd\u8981\u3002\u5b83\u540c\u65f6\u4fc3\u8fdb\u548c\u9650\u5236\u4e86\u76f8\u4e92\u4f5c\u7528<\/strong>\u3002\u5728\u4e09\u7ef4\u4e2d\uff0c\u7269\u8d28\u80fd\u6bd4\u5728\u66f4\u9ad8\u7684\u7ef4\u5ea6\u4e2d\u66f4\u5bb9\u6613\u627e\u5230\u5bf9\u65b9\uff0c\u867d\u7136\u540c\u65f6\u4e5f\u6709\u79cd\u79cd\u4ea4\u4e92\u9650\u5236<\/span>\uff08\u8fd9\u4e00\u70b9\u53c2\u89c1 Bailly & Longo 2011\uff0cP122\uff09<\/span>\u3002\u4f8b\u5982\u67d0\u79cd\u7269\u8d28\u5360\u636e\u4e86\u7a7a\u95f4\u4e2d\u7684\u67d0\u4e2a\u4f4d\u7f6e\uff0c\u90a3\u4e48\u8fd9\u4e2a\u4f4d\u7f6e\u5c31\u4e0d\u80fd\u518d\u88ab\u5176\u5b83\u7269\u8d28\u8fdb\u5165\u3002<\/span>\uff08\u8bd1\u6ce8\uff1a\u6839\u672c\u9650\u5236\u6765\u4e8e\u91cf\u5b50\u529b\u5b66\u7684\u6ce1\u5229\u4e0d\u76f8\u5bb9\u539f\u7406\uff0c\u5bf9\u8d39\u7c73\u5b50\u5982\u5938\u514b\u548c\u7535\u5b50\u7ec4\u6210\u7684\u7cfb\u7edf\uff0c\u4e0d\u80fd\u6709\u4e24\u4e2a\u6216\u4e24\u4e2a\u4ee5\u4e0a\u7c92\u5b50\u540c\u65f6\u5904\u4e8e\u540c\u4e00\u91cf\u5b50\u6001\uff09<\/span>\u3002\u8fd9\u79cd\u6548\u5e94\u5e76\u4e0d\u603b\u5f88\u662f\u5bb9\u6613\u83b7\u5f97\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \u8ba9\u6211\u4eec\u8003\u8651\u4e0b Walter Schubert\u3001Andreas Dress \u53ca\u5408\u4f5c\u8005 toponome \u9879\u76ee\u7684\u4f8b\u5b50<\/span>\uff08Schubert et al.2006\uff09<\/span>\u3002\u4ed6\u4eec\u901a\u8fc7\u53cd\u590d\u67d3\u8272\u548c\u6f02\u767d\u7ec6\u80de\u5207\u7247\uff0c\u8bb0\u5f55\u4e86\u8be5\u5207\u7247\u4e2d\u5927\u7ea6100\u4e2a\u86cb\u767d\u8d28\u7684\u4f4d\u7f6e\uff0c\u7279\u522b\u662f\u83b7\u5f97\u4e86\u5b83\u4eec\u5171\u540c\u4f4d\u7f6e\u7684\u6570\u636e\u3002\u8fd9\u4e9b\u6570\u636e\u901a\u8fc7\u5355\u7eaf\u590d\u5f62\u8fdb\u884c\u6392\u5e8f\uff1a\u5982\u679c\u4ee5\u9876\u70b9\u8868\u793a\u7684\u4e24\u4e2a\u76f8\u5e94\u7684\u86cb\u767d\u8d28\u7ecf\u5e38\u51fa\u73b0\u5728\u76f8\u90bb\u4f4d\u7f6e\uff0c\u5219\u4e24\u4e2a\u9876\u70b9\u4ee5\u8fb9\u76f8\u8fde\u3002\u8fd9\u91cc\u53ef\u4ee5\u8bbe\u7f6e\u4e00\u4e9b\u9608\u503c\uff0c\u5982\u8fd9\u4e9b\u86cb\u767d\u8d28\u5927\u6982\u591a\u9891\u7e41\u4e00\u8d77\u51fa\u73b0\uff0c\u624d\u8bc1\u660e\u5b83\u4eec\u603b\u5171\u540c\u51fa\u73b0\u518d\u5f15\u5165\u76f8\u5e94\u7684\u8fb9\u3002\u7c7b\u4f3c\u5730\uff0c\u5f53\u4e09\u4e2a\u76f8\u5e94\u7684\u86cb\u767d\u8d28\u7ecf\u5e38\u4e00\u8d77\u51fa\u73b0\uff0c\u800c\u975e\u4ec5\u4ec5\u5b83\u4eec\u4e2d\u6bcf\u5bf9\u86cb\u767d\u8d28\u65f6\uff0c\u5c31\u53ef\u4ee5\u63d2\u5165\u4e8c\u7ef4\u5355\u7eaf\u590d\u5f62\uff0c\u5373\u4e00\u4e2a\u4e09\u9876\u70b9\u7684\u4e09\u89d2\u5f62\u3002\u5bf9\u66f4\u9ad8\u7ef4\u7684\u5355\u7eaf\u590d\u5f62\u4e5f\u540c\u6837\u5982\u6b64\u3002\u86cb\u767d\u8d28\u53ea\u5728\u7a7a\u95f4\u4e0a\u63a5\u8fd1\u65f6\u624d\u76f8\u4e92\u4f5c\u7528\uff0c\u56e0\u6b64\u5f53\u5b83\u4eec\u5171\u73b0\u65f6\uff0c\u8fd9\u79cd\u5355\u7eaf\u590d\u5f62\u5c31\u4ee3\u8868\u4e86\u76f8\u4e92\u4f5c\u7528\u6a21\u5f0f\u7684\u67d0\u79cd\u51e0\u4f55\u9aa8\u67b6\u3002\u5f53\u7136\uff0c\u5176\u76f8\u4e92\u4f5c\u7528\u662f\u901a\u8fc7\u5316\u5b66\u4eb2\u548c\u529b<\/span>\uff08chemical affinities\uff09<\/span>\u6765\u5b9e\u73b0\u7684\u3002\u8fd9\u53cd\u8fc7\u6765\u53c8\u5f15\u51fa\u4e86\u4e00\u4e2a\u95ee\u9898\uff0c\u5373\u5728\u8fd9\u4e9b\u6f5c\u5728\u7684\u5316\u5b66\u53cd\u5e94\u4e2d\uff0c\u54ea\u4e00\u79cd\u662f\u5728\u7ec6\u80de\u4e2d\u5b9e\u9645\u5b9e\u73b0\u4e86\u7684\u3002\u4e09\u7ef4\u51e0\u4f55\u5b66\u4f1a\u963b\u6b62\u67d0\u4e9b\u5316\u5b66\u4e0a\u53ef\u80fd\u53d1\u751f\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u6bd5\u7adf\u5e76\u975e\u6240\u6709\u7684\u76f8\u4e92\u4f5c\u7528\u90fd\u80fd\u5728\u7a7a\u95f4\u4e2d\u540c\u65f6\u53d1\u751f\u3002\u8fd9\u6837\u63a5\u4e0b\u6765\u7684\u6570\u5b66\u95ee\u9898\u5c31\u662f\uff0c\u8fd9\u7ed9\u6211\u4eec\u521a\u624d\u63cf\u8ff0\u7684\u5355\u7eaf\u590d\u5f62\u7684\u62d3\u6251\u7ed3\u6784\u5e26\u6765\u4e86\u600e\u6837\u7684\u7ea6\u675f\u3002\u4e3a\u7814\u7a76\u8fd9\u79cd\u5355\u7eaf\u590d\u5f62\uff0cBetti\u6570<\/strong><\/span> (Betti numbers\uff0c\u4ee3\u6570\u62d3\u6251\u4e2d\u7684\u540c\u8c03\u7fa4\u7ef4\u5ea6\uff0c\u53c2\u89c1 Jost (2015) [14])<\/span>\uff0c\u548c\u51e0\u4f55\u4e0d\u53d8\u91cf\u5982\u62c9\u666e\u62c9\u65af\u5149\u8c31<\/span>\uff08Laplacian spectra\uff0cHorak & Jost 2013\uff09<\/span>\u88ab\u7528\u4e8e\u5b9a\u6027\u6bd4\u8f83\u4e0d\u540c\u75c5\u53d8\u7ec6\u80de\u7684\u5171\u540c\u5b9a\u4f4d\u6a21\u5f0f<\/span>\uff08\u4f8b\u5982\uff0c\u5065\u5eb7\u4e0e\u75c5\u53d8\u7684\u7ec6\u80de\uff09<\/span>\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \u5728\u53e6\u4e00\u5c3a\u5ea6\u4e0a\uff0c\u5927\u8111\u7ec4\u7ec7\u4e5f\u662f\u4e09\u7ef4\u7684<\/strong>\u3002\u7531\u4e8e\u4e0d\u662f\u6bcf\u79cd\u7ed3\u6784\u90fd\u80fd\u5728\u7a7a\u95f4\u4e0a\u4e0e\u5176\u5b83\u7ed3\u6784\u76f8\u90bb\uff0c\u66f4\u8fdc\u7684\u7ed3\u6784\u5c31\u9700\u8981\u7528\u751f\u7269\u6027\u7684\u300c\u7ebf\u300d\u8fde\u63a5\u3002\u901a\u8fc7\u7ebf\u7f06\u4f20\u8f93\u4fe1\u606f\u9700\u8981\u65f6\u95f4\uff0c\u8fd9\u5c31\u4f1a\u964d\u4f4e\u4fe1\u53f7\u8fdb\u5165\u5927\u8111\u7684\u5904\u7406\u901f\u5ea6\u3002\u52a0\u539a\u7ebf\u7f06\u867d\u53ef\u4ee5\u63d0\u9ad8\u901f\u5ea6\uff0c\u4f46\u8fd9\u6837\u4e00\u6765\uff0c\u7279\u5b9a\u533a\u57df\u5185\u53ef\u4ee5\u5bb9\u7eb3\u7684\u7ebf\u7f06\u6570\u5c31\u4f1a\u51cf\u5c11\u3002\u56e0\u6b64\uff0c\u5bf9\u4e8e\u5404\u79cd\u76ae\u5c42\u548c\u76ae\u5c42\u4e0b\u7ed3\u6784\u7684\u7f16\u6392\u548c\u5b83\u4eec\u4e4b\u95f4\u7684\u5e03\u7ebf\uff0c\u5b58\u5728\u4e00\u4e2a\u6700\u4f18\u5316\u95ee\u9898\uff0c\u4ee5\u4fbf\u5c3d\u53ef\u80fd\u5feb\u5730\u5904\u7406\u6700\u91cd\u8981\u7684\u4fe1\u53f7\u3002\u4f46\u7531\u4e8e\u8fd9\u4e9b\u4fe1\u53f7\u7684\u91cd\u8981\u6027\u53ca\u5bf9\u5b83\u4eec\u53cd\u5e94\u7684\u5145\u5206\u6027\u53ef\u80fd\u76f8\u5f53\u4e0d\u4e00\u81f4\uff0c\u56e0\u6b64\u8fd8\u5fc5\u987b\u5728\u5404\u79cd\u6570\u636e\u7684\u5904\u7406\u6548\u7387\u4e4b\u95f4\u4f5c\u51fa\u6743\u8861\u3002\u5728\u4e0d\u540c\u7684\u7ed3\u6784\u9650\u5236\u548c\u5386\u53f2\u5076\u53d1\u4e8b\u4ef6\u9a71\u52a8\u4e0b\uff0c\u751f\u7269\u6f14\u5316\u51fa\u4e86\u4e0d\u540c\u7684\u5927\u8111\u7ed3\u6784\uff0c\u4ece\u5934\u8db3\u7c7b\u52a8\u7269\u7684\u5206\u5e03\u5f0f\u5927\u8111\u3001\u5230\u54fa\u4e73\u52a8\u7269\u9519\u7efc\u590d\u6742\u7684\u6298\u53e0\u5f0f\u65b0\u76ae\u5c42\uff0c\u540e\u8005\u4f4d\u4e8e\u5c0f\u8111\u3001\u57fa\u5e95\u795e\u7ecf\u8282\u548c\u6d77\u9a6c\u4f53\u4e4b\u4e0a\uff0c\u5e76\u4e0e\u8fdb\u5316\u4e2d\u66f4\u53e4\u8001\u7684\u7ed3\u6784\u76f8\u4e92\u4f5c\u7528\u3002\u9e1f\u7c7b\u7684\u5927\u8111\u6bd4\u54fa\u4e73\u52a8\u7269\u7684\u8981\u5c0f\u5f97\u591a\uff0c\u66f4\u91cd\u8981\u7684\u662f\u5b83\u8fd8\u66f4\u8f7b\uff0c\u867d\u7136\u7ed3\u6784\u6709\u6240\u4e0d\u540c\uff0c\u4f46\u5374\u5177\u6709\u76f8\u5f53\u9ad8\u7684\u667a\u529b\u6c34\u5e73\u3002\u6211\u4eec\u53ef\u80fd\u4f1a\u95ee\uff0c\u751f\u7269\u8fdb\u5316\u4e3a\u5927\u8111\u7684\u7a7a\u95f4\u7ec4\u7ec7\u80fd\u627e\u5230\u591a\u597d\u7684\u89e3\u51b3\u65b9\u6848\uff1f\u6216\u8005\u662f\u5426\u6709\u53e6\u4e00\u79cd\u5b8c\u5168\u4e0d\u540c\u4f46\u66f4\u52a0\u7cfb\u7edf\u5316\u7684\u8bbe\u8ba1\uff0c\u5bf9\u5f53\u524d\u6709\u5927\u8111\u7684\u751f\u7269\u4f53\u5fc5\u987b\u5904\u7406\u7684\u95ee\u9898\u66f4\u6709\u4f18\u52bf\uff1f<\/span><\/section>\n
       <\/span><\/section>\n
      \u4e00\u4e2a\u5c01\u95ed\u7684\u8868\u9762\u53ef\u4ee5\u4fdd\u62a4\u5176\u5185\u90e8\u514d\u53d7\u5916\u90e8\u5f71\u54cd\u6216\u6270\u52a8\uff0c\u8fd9\u79cd\u4e0d\u53ef\u89e6\u53ca\u6027\u65e2\u6709\u79ef\u6781\u7684\u4e00\u9762\uff0c\u4e5f\u6709\u6d88\u6781\u7684\u4e00\u9762\u3002\u660e\u663e\u7684\u79ef\u6781\u65b9\u9762\uff0c\u4f8b\u5982\u5728 Maturana \u548c Varela \u7684\u81ea\u521b\u751f\u7406\u8bba\u4e2d\u5f3a\u8c03\u7684\uff0c\u662f\u7ec6\u80de\u58c1\u963b\u6b62\u4e86\u7ec6\u80de\u5206\u88c2\uff0c\u540c\u65f6\u6709\u9009\u62e9\u6027\u7684\u6e17\u900f\u4f7f\u6240\u9700\u7684\u7269\u8d28\u80fd\u591f\u6d41\u5165\u3002\u4f46\u8fd9\u6837\uff0c\u4e0e\u4e0d\u5e94\u8be5\u6216\u4e0d\u80fd\u8fdb\u5165\u7ec6\u80de\u7684\u5916\u90e8\u7269\u8d28\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5c31\u9700\u8981\u901a\u8fc7\u7ec6\u80de\u58c1\u4e0a\u7684\u53d7\u4f53\u548c\u5185\u90e8\u4fe1\u53f7\u7ea7\u8054\u6765\u8c03\u8282\u4e86\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \u6211\u4eec\u8bb0\u5f97\uff0c\u5728\u7ec6\u80de\u5185\u90e8\uff0cDNA\u672c\u8d28\u4e0a\u4e0d\u53ef\u80fd\u662f\u4e09\u7ef4\u7684\uff0c\u5426\u5219\u5b83\u5c31\u4e0d\u53ef\u80fd\u88ab\u8f6c\u5f55\u548c\u590d\u5236\u3002<\/span><\/section>\n

      <\/span><\/section>\n
      \u56e0\u6b64\u6211\u4eec\u7684\u7ed3\u8bba\u662f\uff0c\u4fe1\u606f\u3001\u8c03\u63a7\u548c\u51e0\u4f55\u7ed3\u6784\u662f\u76f8\u4e92\u4ea4\u7ec7\u7684<\/strong>\uff0c\u6bcf\u4e00\u79cd\u7406\u8bba\u8bba\u8ff0\u90fd\u5e94\u8be5\u7262\u8bb0\u8fd9\u70b9\u3002<\/span><\/section>\n
       <\/span><\/section>\n

      <\/section>\n
       <\/span>
      <\/section>\n

      \n
      \n
      \n
      \n
      \n

      <\/section>\n

      <\/section>\n
      \n
      <\/svg><\/section>\n<\/section>\n<\/section>\n
      \n

      \u4ea4\u4e92\u4f5c\u7528\u3001\u7f51\u7edc\u548c\u8d85\u56fe<\/strong><\/strong><\/p>\n<\/section>\n

      \n

      <\/section>\n

      <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


      <\/p>\n

      \u86cb\u767d\u8d28\u7684\u5171\u5b9a\u4f4d\u6a21\u5f0f\u4f1a\u5efa\u6210\u65f6\u95f4\u5feb\u7167\uff0c\u540e\u8005\u6784\u6210\u4e86\u4ee3\u8c22\u6216\u5176\u5b83\u751f\u5316\u53cd\u5e94\u7684\u524d\u63d0\u6761\u4ef6\u6216\u8868\u793a\u7ed3\u679c\u3002\u5728\u8fd9\u4e9b\u86cb\u767d\u8d28\u53ef\u80fd\u50ac\u5316\u7684\u53cd\u5e94\u4e2d\uff0c\u8fd8\u4f1a\u6d89\u53ca\u5230\u5176\u5b83\u7269\u8d28\u3002\u4f46\u8fd9\u4e9b\u751f\u5316\u53cd\u5e94\u96c6\u5e76\u4e0d\u662f\u5355\u7eaf\u590d\u5f62\uff0c\u800c\u662f\u5316\u5b66\u8d85\u56fe\u3002<\/span><\/section>\n
       <\/span><\/section>\n
      \u8fd9\u79cd\u7ed3\u6784\u6709\u4e24\u7ec4\u9876\u70b9\uff0c\u5206\u522b\u4ee3\u8868\u79bb\u6790\u7269<\/span>\uff08educts\uff0c\u539f\u6599\u6210\u5206\uff09<\/span>\u548c\u4ea7\u7269\uff0c\u7531\u4ee3\u8868\u5316\u5b66\u53cd\u5e94\u7684\u8d85\u8fb9\u8fde\u63a5\u3002\u8fd9\u4e9b\u9876\u70b9\u96c6\u4e0d\u5fc5\u4e0d\u76f8\u4ea4\uff0c\u56e0\u4e3a\u50ac\u5316\u5242\u53ef\u4ee5\u540c\u65f6\u88ab\u7b97\u4f5c\u53cd\u5e94\u7684\u79bb\u6790\u7269\u548c\u4ea7\u7269\u3002Jost \u548c Mulas<\/span>\uff082019\uff09<\/span>\u5df2\u7ecf\u5f00\u59cb\u5bf9\u8fd9\u79cd\u5316\u5b66\u8d85\u56fe\u8fdb\u884c\u6b63\u5f0f\u5206\u6790\uff0c\u5b83\u53ef\u4ee5\u901a\u8fc7\u62c9\u666e\u62c9\u65af\u8c31\u6216\u5ea6\u91cf\u66f2\u7387<\/span>\uff08metric curvatures\uff09<\/span>\u5206\u5e03\u6765\u89e3\u6790\u3002\u6b64\u5916\u5316\u5b66\u53cd\u5e94\u7f51\u7edc\u4f1a\u53d7\u5316\u5b66\u8ba1\u91cf\u5b66\u7684\u7ea6\u675f\u3002\u5728\u8fd9\u65b9\u9762\uff0cSt.Schuster \u7b49\u4eba\u53d1\u5c55\u4e86\u4e00\u79cd\u5c06\u4ee3\u8c22\u9014\u5f84\u5206\u89e3\u4e3a\u57fa\u672c\u6a21\u5f0f\u7684\u7406\u8bba<\/span>\uff08\u89c1 Klamt and Stelling 2003; Schilling et al. 1999; Schuster et al. 2000; Schuster and Hilgetag 1994)<\/span>\u3002\u5916\u90e8\u6210\u5206\u548c\u80fd\u91cf<\/span>\uff08\u7531ATP\u63d0\u4f9b\uff09<\/span>\u7684\u53ef\u7528\u6027\u548c\u53cd\u5e94\u901f\u7387\uff0c\u4ee5\u53ca\u7a7a\u95f4\u7ec4\u7ec7\uff0c\u90fd\u9650\u5236\u4e86\u4ee3\u8c22\u80fd\u5e73\u884c\u6216\u987a\u5e8f\u751f\u4ea7\u7684\u6570\u91cf\u3002\u5f53\u7136\uff0c\u5176\u4e2d\u534f\u8c03\u3001\u7ba1\u7406\u548c\u63a7\u5236\u4f9d\u7136\u662f\u5fc5\u8981\u7684\u3002<\/span><\/section>\n
       <\/span><\/section>\n
       <\/span>
      <\/section>\n

      \n
      \n
      \n
      \n
      \n

      <\/section>\n

      <\/section>\n
      \n
      <\/svg><\/section>\n<\/section>\n<\/section>\n
      \n

      \u8c03\u63a7<\/strong><\/strong><\/p>\n<\/section>\n

      \n

      <\/section>\n

      <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


      <\/p>\n

      \u6b63\u5982\u6211\u4eec\u5df2\u7ecf\u770b\u5230\u7684\uff0c\u751f\u7269\u8fc7\u7a0b\u8c03\u63a7\u539f\u5219\u4e0a\u53ef\u4ee5\u901a\u8fc7\u7a7a\u95f4\u90bb\u8fd1<\/span>\uff08\u51e0\u4f55\u5b66\uff09<\/span>\u6216\u8054\u5408\u4fe1\u53f7<\/span>\uff08\u4fe1\u606f\uff09<\/span>\u6765\u5b9e\u73b0\u3002\u4e8c\u8005\u90fd\u6ca1\u6709\u5907\u9009\u65b9\u6848\uff0c\u4f46\u53ef\u4ee5\u7075\u6d3b\u7ec4\u5408\u3002\u5176\u4e2d\u7a7a\u95f4\u4ea4\u4e92\u53ef\u80fd\u5177\u6709\u53cc\u91cd\u4f5c\u7528\u3002\u8ba9\u6211\u4eec\u518d\u56de\u987e RNA \u548c\u86cb\u767d\u8d28<\/span>\uff08RNPs\uff09<\/span>\u4e92\u52a8\u7684\u4f8b\u5b50\uff0c\u6709\u4e24\u79cd\u53ef\u80fd\u7684\u529f\u80fd\u4f5c\u7528\uff1a<\/span><\/section>\n
       <\/span><\/section>\n
        \n
      1. \n
        RNA \u4f5c\u4e3a\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7684\u811a\u624b\u67b6\u3002\u7531\u6b64\uff0c\u4e00\u79cd\u7ec6\u80de\u7684\u7279\u5b9a\u7a7a\u95f4\u7ec4\u7ec7\u53ef\u4ee5\u6307\u5bfc\u76f8\u4e92\u4f5c\u7528\u7684\u7279\u5f02\u6027\uff0c\u6216<\/span><\/section>\n<\/li>\n
      2. \n

        \u901a\u8fc7\u4e00\u79cd\u7ec4\u5408\u7f16\u7801\u8c03\u8282\u57fa\u56e0\u8868\u8fbe\uff0c\u7528\u6765\u534f\u8c03\u7279\u5b9a\u57fa\u56e0\u96c6\u5408\u7684\u8868\u8fbe\u3002<\/span><\/p>\n<\/li>\n<\/ol>\n

         <\/span><\/section>\n
        \u7b2c\u4e00\u9879\u518d\u6b21\u5f3a\u8c03\u4e86\u62d3\u6251\u5b66\u7684\u4f5c\u7528\u3002\u56e0\u6b64\uff0cKlaus Scherrer \u548c\u6211\u672c\u4eba\u63d0\u51fa\u4e86\u4e00\u4e2a\u672f\u8bed\u300c\u8c03\u6251\u300d \uff08topon\uff09<\/strong>\uff0c\u7528\u4e8e\u8868\u793a\u5177\u6709\u8c03\u8282\u610f\u4e49\u7684\u51e0\u4f55\u6784\u578b\u3002Scherrer \u548c Jost<\/span>\uff082007a,b,2009\uff09<\/span>\u5219\u7cfb\u7edf\u5730\u9610\u8ff0\u4e86\u7b2c\u4e8c\u9879\u5185\u5bb9\u3002\u4e00\u4e2a\u91cd\u8981\u7684\u751f\u7269\u5b66\u539f\u7406\u662f\uff0c<\/span>\uff08pre-\uff09<\/span>mRNA \u53ea\u6709\u5728\u4e00\u4e9b\u7ed3\u5408\u7684\u86cb\u767d\u88ab\u79fb\u9664\u540e\u624d\u80fd\u8fdb\u4e00\u6b65\u52a0\u5de5\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u53bb\u9664\u7279\u5b9amRNA\u96c6\u5408\u6240\u5171\u6709\u7684\u4e2a\u522b\u86cb\u767d\u8d28\uff0c\u80fd\u591f\u534f\u8c03\u6fc0\u6d3b\u7279\u5b9a\u7684\u57fa\u56e0\u7ec4\u3002<\/span><\/section>\n

        <\/span><\/section>\n
        \u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u4f1a\u770b\u5230\u7ec4\u5408\u6570\u5b66\u7684\u5a01\u529b<\/span>\uff08Jost and Scherrer 2014\uff09<\/span>\u3002\u8fd9\u4e9b\u86cb\u767d\u8d28\u7684\u7ed3\u5408\u57fa\u5e8f\u5305\u542b\u5728 RNA \u5e8f\u5217\u4e2d\uff0c\u56e0\u6b64\u540c\u4e00\u6bb5RNA\u53ef\u80fd\u65e2\u6709\u7f16\u7801\u53c8\u5177\u6709\u8c03\u63a7\u4f5c\u7528\uff0c\u4e3a\u6b64\u6211\u4eec\u63d0\u51fa\u4e86\u8fd9\u79cd\u8c03\u63a7\u57fa\u5e8f\u53e0\u52a0\u5728\u7f16\u7801\u5e8f\u5217\u4e0a\u7684\u672f\u8bed\u300c\u5e8f\u56e0\u300d\uff08genon\uff09<\/strong>\u3002\u4e00\u4e2amRNA\u5927\u7ea6\u670920\u4e2a\u8fd9\u6837\u7684\u86cb\u767d\u8d28\u7ed3\u5408\u70b9\uff0c\u6bcf\u4e2a\u7ed3\u5408\u70b9\u90fd\u4e0e\u5176\u5b83\u4e00\u4e9bRNA\u5171\u4eab\u3002\u56e0\u6b64\uff0c\u4ee55\u4e2a\u7ed3\u5408\u4f4d\u70b9\u4e3a\u4f8b\uff0c\u6709\u4e00\u7ec4\u7279\u5b9a\u7684mRNA\u5177\u6709\u6240\u6709\u7684\u5171\u540c\u70b9\u3002\u5f53\u6240\u6709\u7684\u7ed3\u5408\u4f4d\u70b9\u90fd\u88ab\u5176\u76f8\u5e94\u7684\u86cb\u767d\u8d28\u5360\u636e\u65f6\uff0cmRNA\u5c31\u4e0d\u4f1a\u88ab\u8fdb\u4e00\u6b65\u5904\u7406\uff0c\u800c\u4f1a\u5904\u4e8e\u67d0\u79cd\u4f11\u7720\u72b6\u6001\u3002\u7136\u800c\uff0c\u5f53\u4e00\u5b9a\u6570\u91cf\u7684\uff0c\u4f8b\u59825\u4e2a\uff0c\u8fd9\u4e9b\u86cb\u767d\u8d28\u88ab\u79fb\u9664\u65f6\uff0cmRNA\u5c31\u4f1a\u88ab\u8fdb\u4e00\u6b65\u52a0\u5de5\u5e76\u8f6c\u5316\u6210\u591a\u80bd\u3002\u56e0\u6b64\uff0c\u5f53\u4e00\u4e9b\u4fe1\u53f7\u5373\u8fd95\u4e2a\u86cb\u767d\u8d28\u4ece\u5b83\u4eec\u7684\u6240\u6709\u7ed3\u5408\u4f4d\u70b9\u4e0a\u79fb\u9664\u65f6\uff0c\u4e00\u7ec4\u7279\u5b9a\u7684mRNA\u88ab\u8f6c\u8bd1\u51fa\u6765\u4e86\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u6211\u4eec\u6709\u4e00\u4e9b\u7ec4\u5408\u65b9\u6848\uff0c\u4f7f\u7ec6\u80de\u80fd\u591f\u6839\u636e\u7279\u5b9a\u7684\u8981\u6c42\uff0c\u8f6c\u8bd1\u4e00\u7ec4\u7279\u5b9a\u7684\u57fa\u56e0\u3002\u6240\u6d89\u53ca\u7684\u6570\u91cf\uff0c\u4e0d\u540c\u7684\u7ed3\u5408\u4f4d\u70b9\uff0c\u6bcf\u4e2amRNA\u7684\u7ed3\u5408\u4f4d\u70b9\u548c\u9700\u8981\u53bb\u9664\u5904\u7406\u7684\u86cb\u767d\u8d28\uff0c\u7686\u5982\u6b64\uff0c\u4f1a\u5b58\u5728\u5927\u91cf\u7684\u7ec4\u5408\u53ef\u80fd\u6027\u3002<\/span>\uff08\u8be6\u89c1 Jost and Scherrer 2014, Jost 2014\uff09<\/span><\/section>\n
         <\/span><\/section>\n
        \u8fd9\u80cc\u540e\u7684\u539f\u7406\u53ef\u4ee5\u66f4\u62bd\u8c61\u5730\u8868\u8ff0\u4e3a\u6291\u5236\u7684\u6291\u5236<\/span><\/strong>\u3002DNA\u7684\u81ea\u7136\u503e\u5411\u662f\u88ab\u8f6c\u5f55\u6210RNA\uff0c\u800cRNA\u7684\u81ea\u7136\u503e\u5411\u662f\u8f6c\u5f55\u6210\u86cb\u767d\u8d28\uff0c\u86cb\u767d\u8d28\u6267\u884c\u5176\u529f\u80fd\uff0c\u7136\u540e\u7ec6\u80de\u589e\u6b96\u3002\u4f46\u662f\uff0c\u5982\u679c\u4e00\u4e2a\u7ec6\u80de\u4e2d\u7684\u6240\u6709RNA\u90fd\u88ab\u8f6c\u8bd1\uff0c\u6240\u6709\u7684\u86cb\u767d\u8d28\u90fd\u5c06\u662f\u6d3b\u8dc3\u7684\uff0c\u7ec4\u7ec7\u6216\u6709\u673a\u4f53\u4e2d\u7684\u6240\u6709\u7ec6\u80de\u90fd\u4f1a\u589e\u6b96\uff0c\u90a3\u5c31\u4f1a\u9020\u6210\u5f7b\u5e95\u7684\u6df7\u4e71\uff0c\u7ec6\u80de\u6216\u6709\u673a\u4f53\u529f\u80fd\u90fd\u4f1a\u53d8\u5f97\u5931\u8c03\u3002\u5728\u4efb\u4f55\u7279\u5b9a\u60c5\u51b5\u4e0b\uff0c\u53ea\u6709\u4e00\u5c0f\u90e8\u5206\u4e14\u7279\u5b9a\u7684\u90e8\u5206\u5e94\u8be5\u662f\u6d3b\u8dc3\u7684\u6216\u589e\u6b96\u7684\u3002\u56e0\u6b64\uff0c\u4f5c\u4e3a\u4e00\u822c\u89c4\u5219\uff0c\u6d3b\u6027\u5e94\u8be5\u88ab\u6291\u5236\uff0c\u53ea\u6709\u5f53\u60c5\u51b5\u9700\u8981\u65f6\uff0c\u8fd9\u79cd\u6291\u5236\u624d\u5e94\u8be5\u88ab\u6291\u5236\u3002\u56e0\u6b64\uff0c\u7ec6\u80de\u4e2d\u7684\u5927\u90e8\u5206DNA\u4e0d\u80fd\u7528\u4e8e\u8f6c\u5f55\uff0c\u800c\u662f\u88ab\u5f02\u67d3\u8272\u8d28<\/span>\uff08heterochromatin\uff09<\/span>\u5c4f\u853d\u3002\u5982\u524d\u6240\u8ff0\uff0cRNA\u7684\u8f6c\u8bd1\u662f\u7531\u86cb\u767d\u8d28\u6216\u5176\u5b83\u975e\u7f16\u7801RNA\u6291\u5236\u7684\u3002\u5bf9\u4e8e\u86cb\u767d\u8d28\uff0c\u6211\u4eec\u6709\u53d8\u6784\u6291\u5236<\/strong><\/span>\uff08allosteric inhibition\uff0cMonod et al. 1963\uff09<\/span>\uff0c\u5373\u53e6\u4e00\u4e2a\u86cb\u767d\u8d28\u7ed3\u5408\u5230\u4e00\u4e2a\u86cb\u767d\u8d28\u7684\u975e\u529f\u80fd\u533a\uff0c\u4ece\u800c\u6291\u5236\u5176\u6d3b\u6027\uff0c\u5728\u86cb\u767d\u8d28\u53ef\u4ee5\u53d8\u5f97\u6d3b\u8dc3\u4e4b\u524d\uff0c\u5176\u5b83\u86cb\u767d\u8d28\u9700\u8981\u88ab\u79fb\u9664\uff0c\u901a\u5e38\u7531\u53e6\u4e00\u79cd\u86cb\u767d\u8d28\u79fb\u9664\u3002<\/span><\/section>\n
         <\/span><\/section>\n
        \u751f\u7269\u4f53\u5185\u7ec6\u80de\u65e0\u8282\u5236\u5730\u589e\u6b96\u5c31\u662f\u764c\u75c7\uff0c\u4f46\u6b63\u5982 Longo<\/span>\uff082018\uff09<\/span>\u6240\u4e3b\u5f20\u90a3\u6837\uff0c\u4e3a\u4e86\u7406\u89e3\u764c\u75c7\uff0c\u8ba4\u4e3a\u4e00\u5207\u90fd\u7531DNA\u64cd\u63a7\u7684\u8303\u5f0f\u3001\u7279\u522b\u662fDNA\u7a81\u53d8\u5bfc\u81f4\u4e86\u7ec6\u80de\u65e0\u9650\u589e\u6b96\u662f\u4e0d\u5145\u5206\u7684\uff0c\u4eba\u4eec\u66f4\u5e94\u8be5\u7406\u89e3\u7684\u662f\uff0c\u7a76\u7adf\u662f\u4ec0\u4e48\u8c03\u8282\u673a\u5236\u6291\u5236\u4e86\u5bf9\u7ec6\u80de\u5206\u88c2\u7684\u6291\u5236\u3002\u7c7b\u4f3c\u89c2\u70b9\u5728\u6240\u8c13\u7684\u8fdb\u5316\u533b\u5b66\u4e2d\u4e5f\u88ab\u5e7f\u6cdb\u8ba8\u8bba\u3002\u53e6\u5916\uff0c\u5728\u793e\u4f1a\u6027\u52a8\u7269\u4e2d\uff0c\u901a\u5e38\u4f1a\u6291\u5236\u7fa4\u4f53\u6210\u5458\u7684\u7e41\u6b96\uff0c\u53ea\u5141\u8bb8\u4e00\u4e9b\u6781\u5c11\u6570\u88ab\u9009\u4e2d\u7684\u4e2a\u4f53\u4ea7\u751f\u540e\u4ee3\uff0c\u5c3d\u7ba1\u5728\u8fd9\u91cc\u6211\u4e0d\u60f3\u8ba8\u8bba\u7fa4\u4f53\u9009\u62e9<\/span>\uff08group selection\uff09<\/span>\u8fd9\u4e00\u6709\u4e89\u8bae\u7684\u95ee\u9898\u3002<\/span><\/section>\n
         <\/span><\/section>\n
         <\/span>
        <\/section>\n

        \n
        \n
        \n
        \n
        \n

        <\/section>\n

        <\/section>\n
        \n
        <\/svg><\/section>\n<\/section>\n<\/section>\n
        \n

        \u57fa\u672c\u8bba\u70b9<\/strong><\/strong><\/p>\n<\/section>\n

        \n

        <\/section>\n

        <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


        <\/p>\n

        \u73b0\u5728\uff0c\u6211\u4eec\u5c06\u9610\u8ff0\u6211\u4eec\u7684\u57fa\u672c\u8bba\u70b9\uff08\u4e0d\u540c\u80cc\u666f\u8bf7\u53c2\u89c1 Jost 2019a,b\uff09\uff0c\u5e76\u63a2\u8ba8\u5176\u63a8\u8bba\u3002<\/span><\/section>\n
         <\/span><\/section>\n

        \n
        \u8bba\u70b9 1\uff1a<\/span><\/strong><\/span><\/section>\n

        <\/span><\/strong><\/span><\/section>\n<\/h4>\n
        \u751f\u7269\u5b66\u7684\u5173\u952e\u539f\u5219\u662f\uff0c\u4e00\u4e2a\u8fc7\u7a0b\u53ef\u4ee5\u63a7\u5236\u548c\u8c03\u8282\u5176\u5b83\u8fc7\u7a0b\u3002<\/span><\/section>\n
         <\/span><\/section>\n

        \u4f8b\u5b50\uff1a<\/span><\/p>\n

          \n
        • \n
          DNA\u4e0a\u7684\u542f\u52a8\u5b50\u3001\u6291\u5236\u5b50\u7b49\u4f4d\u70b9\u5bf9\u7f16\u7801\u533a\u6ca1\u6709\u7279\u5f02\u6027\uff0c\u4f46\u53cd\u6620\u4e86\u8c03\u8282\u673a\u5236\uff1b<\/span><\/section>\n<\/li>\n
        • \n
          \u5728RNA\u6c34\u5e73\u4e0a\u6709\u8bb8\u591a\u4e00\u822c\u7ec4\u5408\u8c03\u8282\u673a\u5236<\/span>\uff08\u4e0d\u540cRNA\u3001RNA\u548c\u86cb\u767d\u8d28\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff09<\/span>\uff0c\u5176\u4e2d\u4e00\u4e9b\u5728\u8c03\u63a7\u4e00\u8282\u5df2\u6709\u9610\u8ff0\uff1b<\/span><\/section>\n<\/li>\n
        • \n
          \u540c\u6e90\u5f02\u5f62\u57fa\u56e0<\/span>\uff08Hoxgenes\uff09<\/span>\u662f\u8de8\u7269\u79cd\u7684\u4e00\u822c\u8c03\u8282\u673a\u5236<\/span>\uff08Gehring 199\uff09<\/span>\uff1b<\/span><\/section>\n<\/li>\n
        • \n
          \u53d8\u6784\u8c03\u8282\u539f\u5219\u5728\u8c03\u63a7\u4e00\u8282\u4e5f\u5df2\u9610\u8ff0\uff1b<\/span><\/section>\n<\/li>\n
        • \n
          \u6606\u866b\u6709\u4e00\u79cd\u4e00\u822c\u7684\u3001\u975e\u7279\u5f02\u6027\u7684\u8c03\u8282\u673a\u5236\uff0c\u5c06\u611f\u89c9\u8f93\u5165\u8f6c\u5316\u4e3a\u8fd0\u52a8\u6d3b\u52a8\u3002\u56e0\u6b64\u5b83\u4eec\u53ef\u4ee5\u7075\u6d3b\u5730\u5c06\u4f20\u611f\u5668\u4e0e\u6267\u884c\u5668\u7ed3\u5408\u8d77\u6765\uff1b<\/span><\/section>\n<\/li>\n
        • \n
          \u5728\u300c\u8fdb\u5316-\u9000\u5316\u300d<\/span>\uff08Evo-Devo\uff0c\u53ef\u4ee5\u770b\u4f5c\u662f\u5bf9\u65b0\u8fbe\u5c14\u6587\u8303\u5f0f\u7684\u6311\u6218\uff09<\/span>\u7684\u7814\u7a76\u65b9\u5411\u4e2d\uff0c\u5173\u952e\u662f\u63a7\u5236\u673a\u5236\u7684\u91cd\u7ec4<\/span>\uff08\u4f8b\u5982\u89c1 Carroll et al. 2005; Laubichler 2007\uff09<\/span>\u3002<\/span><\/section>\n<\/li>\n<\/ul>\n
           <\/span><\/section>\n
          \u8fd9\u4e9b\u4f8b\u5b50\u5c06\u6211\u4eec\u5e26\u5230\u4e0b\u4e00\u4e2a\u8bba\u9898\u3002<\/span><\/section>\n
           <\/span><\/section>\n

          \n
          \u8bba\u70b9 2\uff1a<\/span><\/strong><\/section>\n

          <\/span><\/strong><\/section>\n<\/h4>\n
          \u8fd9\u4e9b\u53d7\u63a7\u8fc7\u7a0b\u7684\u5185\u5bb9\u53ea\u6709\u5728\u670d\u52a1\u4e8e\u63a7\u5236\u8fc7\u7a0b\u7684\u60c5\u51b5\u4e0b\u624d\u91cd\u8981\u3002<\/span><\/strong><\/section>\n

          <\/span><\/strong><\/section>\n
          \u8fd9\u6697\u793a\u7740\u300c\u4ec0\u4e48\u662f\u76f8\u5173\u4fe1\u606f\uff1f\u300d\u8fd9\u4e2a\u95ee\u9898\u7684\u63d0\u51fa\u3002\u5b83\u5c06\u5bfc\u51fa\u4e00\u79cd\u751f\u7269\u4fe1\u606f\u7684\u65b0\u6982\u5ff5\u3002<\/span><\/section>\n
           <\/span><\/section>\n

          \n
          \u8bba\u70b9 3\uff1a<\/span><\/strong><\/span><\/section>\n

          <\/span><\/section>\n<\/h4>\n
          \u76f8\u5173\u4fe1\u606f<\/span>\uff08relevant information\uff09<\/span>\u662f\u4ec5\u4ec5\u7528\u4e8e\u8c03\u8282\u548c\u63a7\u5236\u6240\u9700\u7684\u4fe1\u606f<\/strong>\u3002\u5b83\u53ef\u80fd\u975e\u5e38\u5c11\uff0c\u4f46\u662f\u751f\u7269\u7cfb\u7edf\u9700\u8981\u80fd\u591f\u5b58\u50a8\u3001\u8bb0\u5fc6\u6216\u4fdd\u5b58\u8fd9\u4e9b\u4fe1\u606f\u3002<\/span><\/section>\n
           <\/span><\/section>\n
          \u8ba9\u6211\u4eec\u6765\u8ba8\u8bba\u4e00\u4e9b\u5b9e\u9645\u4f8b\u5b50\u548c\u5e94\u7528\u3002<\/span><\/section>\n
           <\/span><\/section>\n
            \n
          1. \n
            \u6700\u5f00\u59cb\u7684\u75c5\u6bd2\u4e5f\u8bb8\u662f\u6700\u6781\u7aef\u7684\u4f8b\u5b50\uff0c\u53ea\u9700\u8981\u300c\u77e5\u9053\u300d\u5982\u4f55\u627e\u5230\u4e00\u4e2a\u5bbf\u4e3b\uff0c\u518d\u5c06DNA\u6216RNA\u6ce8\u5165\u5230\u5bbf\u4e3b\u7ec6\u80de\u3002\u56e0\u6b64\u75c5\u6bd2\u7684\u9057\u4f20\u4fe1\u606f\u53ef\u4ee5\u5f88\u77ed\u3002\u75c5\u6bd2\u4f1a\u63a7\u5236\u5bbf\u4e3b\u7684\u65b0\u9648\u4ee3\u8c22\u8fc7\u7a0b\uff0c\u4ee5\u786e\u4fdd\u590d\u5236\u81ea\u8eab\uff0c\u8fc7\u7a0b\u5982\u4f55\u8fd0\u4f5c\u5012\u662f\u65e0\u5173\u7d27\u8981\u7684\u3002<\/span><\/section>\n<\/li>\n
          2. \n
            \u9ad8\u7b49\u52a8\u7269\uff0c\u4f8b\u5982\u54fa\u4e73\u52a8\u7269\uff0c\u5728\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u53ef\u4ee5\u9009\u62e9\u54ea\u4e9b\u4ee3\u8c22\u4ea7\u7269\u9700\u8981\u81ea\u5df1\u5236\u9020\uff0c\u54ea\u4e9b\u53ea\u9700\u4f5c\u4e3a\u98df\u7269\u6444\u5165\u3002\u7ef4\u751f\u7d20\u662f\u4e2a\u5178\u578b\u4f8b\u5b50\u3002\u5b83\u4eec\u662f\u65b0\u9648\u4ee3\u8c22\u7684\u5fc5\u9700\u54c1\uff0c\u4f46\u751f\u4ea7\u5374\u662f\u5916\u90e8\u5316\u7684\u3002\u56e0\u6b64\uff0c\u52a8\u7269\u5c31\u4e0d\u518d\u9700\u8981\u5728\u81ea\u5df1\u57fa\u56e0\u7ec4\u4e2d\u50a8\u5b58\u4e0e\u4e4b\u76f8\u5173\u7684\u4ee3\u8c22\u8fc7\u7a0b\u4fe1\u606f\uff0c\u800c\u662f\u50a8\u5b58\u5982\u4f55\u83b7\u53d6\u542b\u6709\u5fc5\u8981\u7ef4\u751f\u7d20\u7684\u98df\u7269\u7684\u4fe1\u606f\u3002<\/span><\/section>\n<\/li>\n
          3. \n
            \u4e0a\u8ff0\u4e24\u4e2a\u4f8b\u5b50\u7684\u4e00\u4e2a\u5171\u540c\u70b9\u662f\uff0c\u751f\u7269\u6709\u673a\u4f53\u6216\u8fc7\u7a0b<\/strong><\/span>\uff08\u59d1\u4e14\u628a\u75c5\u6bd2\u590d\u5236\u4e5f\u770b\u4f5c\u662f\u4e00\u79cd\u751f\u7269\u8fc7\u7a0b\u7684\u8bdd\uff09<\/span>\u4f9d\u8d56\u4e8e\u4e00\u4e2a\u53ef\u80fd\u6bd4\u81ea\u5df1\u590d\u6742\u5f97\u591a\u7684\u73af\u5883<\/strong>\u3002\u6709\u5173\u5982\u4f55\u751f\u4ea7\u7ef4\u751f\u7d20\u7684\u4ee3\u8c22\u4fe1\u606f\u53ef\u80fd\u6bd4\u5bfb\u627e\u9002\u5f53\u98df\u7269\u6765\u6e90\u7684\u4fe1\u606f\u91cf\u8981\u5927\u5f97\u591a\uff0c\u4f46\u751f\u7269\u4f53\u6216\u8fc7\u7a0b\u53ea\u9700\u8981\u540e\u8005\u3002<\/span><\/section>\n<\/li>\n
          4. \n
            \u751f\u7269\u6709\u673a\u4f53\u4e0d\u4ec5\u5229\u7528\u73af\u5883\u4e2d\u7684\u5176\u4ed6\u6709\u673a\u4f53\u6216\u8fc7\u7a0b\uff0c\u800c\u6216\u8bb8\u66f4\u4e3a\u57fa\u672c\u7684\u662f\uff0c\u5b83\u4f1a\u5229\u7528\u7269\u7406\u89c4\u5f8b\u3002\u4f8b\u5982\uff0c\u5728\u8bb8\u591a\u52a8\u7269\u7684\u8fd0\u52a8\u4e2d\uff0c\u91cd\u529b\u662f\u88ab\u79ef\u6781\u5229\u7528\u7684\u3002\u6211\u4eec\u7684\u8eab\u4f53\u9002\u5e94\u5728\u975e\u5e38\u7279\u6b8a\u7684\u91cd\u529b\u4f5c\u7528\u4e0b\u884c\u8d70\u3002\u673a\u5668\u4eba\u6280\u672f\u6700\u8fd1\u4e5f\u5b66\u4f1a\u4e86\u5229\u7528\u91cd\u529b\uff0c\u800c\u975e\u53bb\u7cbe\u5fc3\u8bbe\u8ba1\u884c\u8d70\u673a\u5668\u4eba\u6240\u6709\u5173\u8282\u7684\u4f4d\u7f6e\u3002\u8fd9\u5c31\u662f\u6240\u8c13\u7684\u5177\u8eab\u5316<\/strong><\/span>\uff08embodiment\uff09<\/span>\u3002<\/span><\/section>\n<\/li>\n
          5. \n
            \u65e2\u7136\u751f\u7269\u6709\u673a\u4f53\u65e2\u4f9d\u8d56\u4e8e\u590d\u6742\u7684\u73af\u5883\uff0c\u53c8\u4f9d\u8d56\u4e8e\u7269\u7406\u89c4\u5f8b\u7684\u8fd0\u884c\uff0c\u90a3\u4e48\u6211\u4eec\u80fd\u5426\u5728\u5176\u5b83\u661f\u7403\u4e0a\u5efa\u7acb\u4eba\u7c7b\u7684\u751f\u6d3b\u5c31\u4ee4\u4eba\u6000\u7591\u3002\u867d\u7136\u6211\u4eec\u53ef\u4ee5\u63a7\u5236\u5176\u5b83\u7269\u7406\u53c2\u6570\uff0c\u5982\u6e29\u5ea6\u6216\u6c27\u6c14\u4f9b\u5e94\uff0c\u4f46\u6211\u4eec\u7684\u8eab\u4f53\u5e76\u4e0d\u9002\u5408\u5728\u4e0d\u540c\u7684\u91cd\u529b\u5f3a\u5ea6\u4e0b\u5de5\u4f5c\u3002\u65e0\u8bba\u6211\u4eec\u80fd\u591f\u521b\u9020\u51fa\u4ec0\u4e48\u6837\u7684\u4eba\u5de5\u751f\u7269\u73af\u5883\uff0c\u5b83\u90fd\u4e0d\u8db3\u4ee5\u957f\u65f6\u95f4\u7ef4\u6301\u4eba\u7c7b\u7684\u751f\u547d\u3002<\/span><\/section>\n<\/li>\n
          6. \n
            Ashby \u7684\u5fc5\u8981\u53d8\u5f02\u5ea6\u5b9a\u5f8b<\/strong><\/span>\uff08law of requisite variety\uff0cAshby 1956\uff09<\/span>\u662f\u4e0d\u6b63\u786e\u7684\u3002\u8be5\u5b9a\u5f8b\u8bf4\uff0c\u4e00\u4e2a\u7cfb\u7edf\u9700\u8981\u4fdd\u6301\u8db3\u591f\u7684\u591a\u6837\u6027\u6765\u5339\u914d\u6240\u6709\u7684\u5916\u90e8\u6270\u52a8\uff0c\u82e5\u5b83\u8981\u5728\u8fd9\u4e9b\u6270\u52a8\u4e0b\u4fdd\u8bc1\u6301\u7eed\u5b58\u5728\u3002\u4e8b\u5b9e\u4e0a\uff0c\u6839\u636e\u6211\u4eec\u7684\u7406\u8bba\uff0c\u7cfb\u7edf\u9700\u8981\u7684\u4e1c\u897f\u8981\u5c11\u5f97\u591a\u3002\u5b83\u53ea\u9700\u8981\u63a7\u5236\u67d0\u4e9b\u8fc7\u7a0b\uff0c\u6216\u76f4\u63a5\u63a7\u5236\u90a3\u4e9b\u4ea7\u751f\u6270\u52a8\u7684\u8fc7\u7a0b\uff0c\u6216\u63a7\u5236\u5176\u5b83\u5904\u7406\u8fd9\u4e9b\u6270\u52a8\u7684\u8fc7\u7a0b\u5373\u53ef\u3002<\/span><\/section>\n<\/li>\n
          7. \n
            \u524d\u9762\u7684\u5927\u591a\u6570\u4f8b\u5b50\u548c\u8bba\u70b9\u90fd\u63d0\u51fa\u4e86\u5916\u90e8\u5316\u7684\u5b9e\u4f8b\uff0c\u5373\u5f53\u5916\u90e8\u8fc7\u7a0b\u88ab\u521b\u9020\u6216\u5229\u7528\u6765\u4e3a\u76f8\u5173\u751f\u7269\u4f53\u6267\u884c\u67d0\u79cd\u529f\u80fd\u65f6\u3002\u8bb8\u591a\u8fd9\u6837\u7684\u4f8b\u5b50\u90fd\u662f\u751f\u6001\u4f4d\u6784\u5efa\u7684\u5b9e\u4f8b\uff0c\u6b63\u5982 Laubichler \u548c Renn<\/span> (2015) <\/span>\u6240\u6307\u51fa\u7684\u3002\u53cd\u4e4b\u4ea6\u7136\uff0c\u5916\u90e8\u8fc7\u7a0b\u88ab\u5185\u90e8\u5316\u4e5f\u540c\u7b49\u91cd\u8981\u3002\u4f8b\u5982\uff0c\u771f\u6838\u7ec6\u80de\u4e2d\u7684\u7ebf\u7c92\u4f53\u8d77\u6e90\u4e8e\u751f\u7269\u5b9e\u4f53\uff0c\u672c\u8d28\u4e0a\u662f\u539f\u672c\u72ec\u7acb\u7684\u7ec6\u83cc\uff0c\u4f46\u540e\u6765\u88ab\u5408\u5e76\u5230\u90a3\u4e9b\u771f\u6838\u7ec6\u80de\u4e2d\u7528\u4e8e\u65b0\u9648\u4ee3\u8c22\u8fc7\u7a0b\u3002\u66f4\u5e7f\u6cdb\u800c\u8a00\uff0c\u8c03\u8282\u7f51\u7edc\u6b63\u53d8\u5f97\u8d8a\u6765\u8d8a\u590d\u6742\uff0c\u4ee5\u63a7\u5236\u8d8a\u6765\u8d8a\u590d\u6742\u7684\u5185\u90e8\u8fc7\u7a0b\u3002<\/span><\/section>\n<\/li>\n
          8. \n
            \u540c\u4e00\u65b9\u5411\u4e0a\uff0c\u4e3a\u4ec0\u4e48\u6a21\u62df\u86cb\u767d\u8d28\u6298\u53e0\u5982\u6b64\u56f0\u96be\u7684\u95ee\u9898\uff0c\u7b54\u6848\u53ef\u80fd\u5e76\u975e\u5728\u7269\u7406<\/span>\uff08\u5177\u6709\u8bb8\u591a\u4e9a\u7a33\u6001\u80fd\u91cf\u666f\u89c2\uff09<\/span>\uff0c\u800c\u662f\u771f\u6b63\u751f\u7269\u7684\uff1a\u80fd\u91cf\u666f\u89c2<\/span>\uff08energy landscape\uff09<\/span>\u7684\u8fdb\u5316\u662f\u4e3a\u4e86\u63d0\u4f9b\u5728\u4e0d\u540c\u6784\u8c61<\/span>\uff08conformations\uff09<\/span>\u4e4b\u95f4\u5207\u6362\u7684\u7075\u6d3b\u6027\u3002<\/span><\/section>\n<\/li>\n
          9. \n

            \u751f\u7269\u8fc7\u7a0b\u65e2\u80fd\u5728\u4e0d\u540c\u5c42\u6b21\u4e0a\u63a7\u5236\u548c\u5f7c\u6b64\u8c03\u8282\uff0c\u4e5f\u80fd\u540c\u7ea7\u95f4\u76f8\u4e92\u8c03\u8282\u3002\u8fc7\u7a0b\u548c\u7ea6\u675f\u53ef\u4ee5\u5728\u65f6\u95f4\u5c3a\u5ea6\u4e4b\u95f4\u548c\u4e4b\u5185\u8f6c\u53d8\u5f7c\u6b64\u89d2\u8272<\/span>\uff08Mont\u00e9vil and Mossio 2015\uff09<\/span>\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u5bf9\u4ec0\u4e48\u662f\u88ab\u63a7\u5236\u548c\u8c03\u8282\u7684\uff0c\u4ec0\u4e48\u5728\u88ab\u63a7\u5236\uff0c\u53ef\u80fd\u53d6\u51b3\u4e8e\u89c6\u89d2\u3002\u8fd9\u79cd\u4e92\u9988\u6027\u662f\u751f\u7269\u751f\u547d\u7684\u4e00\u4e2a\u57fa\u672c\u65b9\u9762\uff0c\u4ece\u7ec6\u80de\u548c\u751f\u7269\u4f53\u5185\uff0c\u76f4\u5230\u751a\u81f3\u751f\u7269\u5708\u7684\u89c4\u6a21\u3002<\/span><\/p>\n<\/li>\n<\/ol>\n

             <\/span><\/section>\n
            \u56e0\u6b64\u6211\u4eec\u770b\u5230\uff0c\u4ece\u4ee5\u4e0a\u8fd9\u4e9b\u8bba\u70b9\u7684\u89d2\u5ea6\uff0c\u8bb8\u591a\u975e\u5e38\u4e0d\u540c\u7684\u751f\u7269\u73b0\u8c61\u5c31\u80fd\u5728\u6982\u5ff5\u4e0a\u843d\u5730\uff0c\u5e76\u83b7\u5f97\u8fdb\u5316\u7684\u610f\u4e49\u3002<\/span><\/section>\n

            <\/section>\n
             <\/span>
            <\/section>\n

            \n
            \n
            \n
            \n
            \n

            <\/section>\n

            <\/section>\n
            \n
            <\/svg><\/section>\n<\/section>\n<\/section>\n
            \n

            \u8fdb\u5316<\/strong><\/strong><\/p>\n<\/section>\n

            \n

            <\/section>\n

            <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


            <\/p>\n

            \u4ece\u751f\u7269\u8fdb\u5316\u7684\u89d2\u5ea6\u6765\u770b\uff0c\u6700\u91cd\u8981\u7684\u8fc7\u7a0b\u662f\u7e41\u6b96\u3002\u7e41\u6b96\u7684\u57fa\u672c\u589e\u957f\u89c4\u5f8b\u662f\u7531\u6307\u6570\u51fd\u6570\u7ed9\u51fa\u7684\u3002\u5f53\u6307\u6570\u4e3a\u6b63\u65f6\uff0c\u7e41\u6b96\u7684\u65cf\u7cfb\u53ca\u5404\u79cd\u4ea7\u7269\u90fd\u5728\u6269\u5f20\uff0c\u8c01\u7684\u6307\u6570\u6700\u9ad8\uff0c\u5c31\u6269\u5f20\u5f97\u6700\u5feb\uff0c\u80fd\u80dc\u8fc7\u4ed6\u8005\u3002\u4f46\u662f\u4e3a\u4e86\u6269\u5f20\uff0c\u8fc7\u7a0b\u9700\u8981\u4ece\u5916\u90e8\u5438\u53d6\u7269\u8d28\u548c\u80fd\u91cf\u3002\u7531\u4e8e\u4e8c\u8005\u90fd\u662f\u6709\u9650\u7684\uff0c\u8fd9\u5c31\u4e0d\u53ef\u907f\u514d\u5730\u5bfc\u81f4\u4e86\u5bf9\u7a00\u7f3a\u8d44\u6e90\u7684\u7ade\u4e89\u3002<\/span><\/section>\n
             <\/span><\/section>\n
            \u6839\u636e\u8fbe\u5c14\u6587\u8303\u5f0f<\/span>\uff08Darwin 1985\uff09<\/span>\uff0c\u7ade\u4e89\u5bfc\u81f4\u9009\u62e9\u3002\u6210\u529f\u7684\u7269\u79cd\u4f1a\u6269\u5f20\u3002\u663e\u7136\u4e00\u5757\u77f3\u5934\u4e0d\u80fd\u6269\u5f20\uff0c\u4f46\u4e00\u4e2a\u751f\u7269\u7269\u79cd<\/span>\uff08\u6216\u4e00\u4e2a\u7ec6\u83cc\u7fa4\u843d\u3001\u4e00\u4e2a\u75c5\u6bd2\u7fa4\uff09<\/span>\u53ef\u4ee5\uff0c\u56e0\u4e3a\u5b83\u7684\u6210\u5458\u90fd\u53ef\u4ee5\u63a7\u5236\u81ea\u8eab\u4e4b\u5916\u7684\u8fc7\u7a0b\u3002\u63a7\u5236\u7684\u7e41\u884d\u9700\u8981\u4fe1\u606f\u4f20\u8f93\u3002\u4e0e\u7269\u8d28\u6216\u80fd\u91cf\u4e0d\u540c\uff0c\u4fe1\u606f\u4e0d\u9075\u5faa\u5b88\u6052\u5b9a\u5f8b\uff0c\u56e0\u6b64\u4e00\u4e2a\u751f\u7269\u4f53\u53ef\u4ee5\u4ea7\u751f\u8bb8\u591a\u540e\u4ee3\u3002\u5728\u751f\u7269\u4fe1\u606f\u4f20\u8f93<\/span>\uff08Jost 2020\uff09<\/span>\u4e2d\u8be6\u7ec6\u5206\u6790\u4e86\u8fd9\u4e00\u4e3b\u9898\uff0c\u4fe1\u606f\u65e2\u9700\u8981\u4e5f\u8981\u786e\u4fdd\u4e00\u5b9a\u7684\u89c4\u5f8b\u6027\u6216\u53ef\u91cd\u590d\u6027\uff0c\u56e0\u4e3a\u4f20\u8f93\u7684\u4fe1\u606f\u4e0d\u80fd\u88ab\u8fc7\u5ea6\u4fee\u6539\u800c\u53d8\u5f97\u65e0\u7528\uff0c\u9664\u975e\u5b83\u5076\u7136\u53c8\u78b0\u5230\u4e86\u65b0\u7684\u63a7\u5236\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u53ea\u6307\u51fa\uff0c\u7531\u4e8e\u8fd9\u79cd\u89c4\u5f8b\u6027\u548c\u53ef\u91cd\u590d\u6027\uff0c\u751f\u7269\u8fc7\u7a0b\u5728\u8bb8\u591a\u5c3a\u5ea6\u901a\u5e38\u662f\u5468\u671f\u6027\u7684\uff0c\u4e5f\u8bb8\u6709\u5fae\u5c0f\u7684\u53d8\u5316\u3002<\/span><\/section>\n

            <\/section>\n


            <\/p>\n

            \n
            \n
            \n

            \u53c2\u8003\u6587\u732e<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

            \n
            \n
            \n
            \n


            <\/p>\n