{"id":29935,"date":"2021-11-11T21:36:14","date_gmt":"2021-11-11T13:36:14","guid":{"rendered":"https:\/\/swarma.org\/?p=29935"},"modified":"2021-11-11T21:36:14","modified_gmt":"2021-11-11T13:36:14","slug":"%e8%80%81%e8%8d%af%e6%96%b0%e7%94%a8%e6%b2%bb%e7%96%97%e6%96%b0%e5%86%a0%e7%96%be%e7%97%85%ef%bc%9f%e7%bd%91%e7%bb%9c%e5%8c%bb%e5%ad%a6%e6%a1%86%e6%9e%b6%e5%8a%a0%e9%80%9f%e8%8d%af%e7%89%a9%e7%a0%94","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=29935","title":{"rendered":"\u8001\u836f\u65b0\u7528\u6cbb\u7597\u65b0\u51a0\u75be\u75c5\uff1f\u7f51\u7edc\u533b\u5b66\u6846\u67b6\u52a0\u901f\u836f\u7269\u7814\u53d1"},"content":{"rendered":"
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2021\u5e745\u6708\uff0cPNAS<\/em> \u520a\u8f7d\u4e86\u7f51\u7edc\u79d1\u5b66\u5bb6 Albert-L\u00e1szl\u00f3 Barab\u00e1si \u7ec4<\/strong>\u7684\u7814\u7a76\uff1a\u201c\u7528\u4e8e\u8bc6\u522b\u8001\u836f\u65b0\u7528\u6cbb\u7597COVID-19\u53ef\u80fd\u6027\u7684\u7f51\u7edc\u533b\u5b66\u6846\u67b6\u201d\u3002\u7814\u7a76\u9664\u4e86\u57fa\u4e8e\u5b9e\u9a8c\u6d4b\u5f97\u7684\u65b0\u51a0\u76f8\u5173\u76f8\u4e92\u4f5c\u7528\u7ec4\u6570\u636e\u5916\uff0c\u8fd8\u5145\u5206\u5229\u7528\u4e86\u5176\u5b83\u590d\u6742\u751f\u7269\u7f51\u7edc\u4fe1\u606f\uff0c\u4ee5\u65b0\u51a0\u6cbb\u7597\u7684\u8001\u836f\u65b0\u7528\u4e3a\u4f8b\uff0c\u5c1d\u8bd5\u5efa\u7acb\u4e00\u79cd\u9ad8\u53ef\u4fe1\u5ea6\u7684\u865a\u62df\u7b5b\u9009\u65b9\u5f0f\uff0c\u52a0\u901f\u836f\u7269\u7814\u53d1\u8fdb\u7a0b\u3002<\/strong><\/p>\n


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Network medicine framework for identifying drug-repurposing opportunities for COVID-19<\/span><\/p>\n

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https:\/\/www.pnas.org\/content\/118\/19\/e2025581118<\/span><\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n


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COVID-19\u5927\u6d41\u884c\u8fc5\u731b\u5f02\u5e38\uff0c\u8868\u660e\u4eba\u7c7b\u9700\u8981\u5feb\u901f\u5f00\u53d1\u3001\u6d4b\u8bd5\u548c\u90e8\u7f72\u65b0\u836f\u7684\u65b9\u6cd5\u3002\u4ece\u5934\u836f\u7269\u5f00\u53d1<\/span>\uff08de novo drug development\uff09<\/span>\u8fc7\u7a0b\u52a8\u8f84\u8017\u65f6\u5341\u5e74\uff0c\u663e\u7136\u4e0d\u53ef\u884c\uff1b\u60f3\u8981\u8282\u7701\u65f6\u95f4\uff0c\u5fc5\u987b\u8001\u836f\u65b0\u7528<\/strong><\/span>\uff08drug repurposing\uff09<\/span>\uff0c\u4ece\u5df2\u6279\u51c6\u7684\u836f\u7269\u4e2d\u786e\u5b9a\u5c11\u6570\u53ef\u80fd\u5bf9COVID-19\u6709\u6cbb\u7597\u4f5c\u7528\u7684\u5316\u5408\u7269\u3002<\/span><\/p>\n


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Barab\u00e1si \u7ec4\u7684\u7814\u7a76\u5b9e\u73b0\u4e86\u4e09\u7c7b\u7f51\u7edc\u533b\u5b66\u8001\u836f\u65b0\u7528\u7b97\u6cd5\u9884\u6d4b\u5019\u9009\u836f\u7269\u3002\u7ed3\u679c\u53d1\u73b0\uff0c\u4e0d\u540c\u65b9\u6cd5\u7684\u9884\u6d4b\u80fd\u529b\u5747\u8f83\u5f3a\uff0c\u800c\u63d0\u53d6\u5230\u7684\u7279\u5f81\u6709\u522b\u3002\u800c\u5982\u679c\u5728\u8fd9\u4e09\u79cd\u9884\u6d4b\u65b9\u6cd5\u4e4b\u95f4\u5bfb\u6c42\u5171\u8bc6\uff0c\u91c7\u7528\u4e00\u79cd\u591a\u6a21\u6001\u96c6\u6210\u9884\u6d4b\u65b9\u6cd5\uff0c\u5219\u53ef\u4ee5\u663e\u8457\u63d0\u9ad8\u9884\u6d4b\u7684\u51c6\u786e\u6027\u548c\u53ef\u9760\u6027<\/strong> [15, 19]\u3002<\/span><\/p>\n


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1) \u57fa\u4e8e AI \u7684\u7b97\u6cd5<\/strong> [15,16]\u3002\u4f7f\u7528\u56fe\u795e\u7ecf\u7f51\u7edc\uff0c\u5c06\u836f\u7269\u86cb\u767d\u8d28\u9776\u70b9\u548c\u75be\u75c5\u76f8\u5173\u86cb\u767d\u8d28\u6620\u5c04\u5230\u4f4e\u7ef4\u5411\u91cf\u7a7a\u95f4\u4e2d\u7684\u70b9\uff0c\u4ece\u800c\u4ea7\u751f\u4f9d\u8d56\u4e8e\u4e0d\u540c\u836f\u7269-\u75be\u75c5\u5d4c\u5165\u7684\u56db\u4e2a\u9884\u6d4b\u7ba1\u7ebf\uff08A1-A4\uff09\u3002<\/span><\/p>\n


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2) \u57fa\u4e8e\u7f51\u7edc\u6269\u6563\u7684\u7b97\u6cd5<\/strong> [17]\u3002\u53d7\u6269\u6563\u72b6\u6001\u8ddd\u79bb\u7684\u542f\u53d1\uff0c\u6839\u636e\u836f\u7269\u86cb\u767d\u8d28\u9776\u6807\u4e0e\u65b0\u51a0\u75c5\u6bd2\u5bbf\u4e3b\u86cb\u767d\u8d28\u9776\u6807\u7684\u7f51\u7edc\u76f8\u4f3c\u6027\u5bf9\u836f\u7269\u8fdb\u884c\u6392\u5e8f\uff0c\u8be5\u7b97\u6cd5\u7531\u4e0d\u540c\u7684\u7edf\u8ba1\u65b9\u6cd5\u63d0\u4f9b\u652f\u6301\uff0c\u63d0\u4f9b\u4e94\u4e2a\u6392\u540d\u7ba1\u7ebf\uff08D1-D5\uff09\u3002<\/span><\/p>\n


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3\uff09\u57fa\u4e8e\u7f51\u7edc\u90bb\u8fd1\u5ea6\u7684\u7b97\u6cd5<\/strong> [11]\u3002\u6839\u636e\u65b0\u51a0\u75c5\u6bd2\u5bbf\u4e3b\u86cb\u767d\u9776\u70b9\u4e0e\u836f\u7269\u6700\u8fd1\u86cb\u767d\u9776\u70b9\u4e4b\u95f4\u7684\u8ddd\u79bb\u5bf9\u836f\u7269\u8fdb\u884c\u6392\u5e8f\uff0c\u5f97\u5230\u4e09\u4e2a\u9884\u6d4b\u7ba1\u7ebf\uff08P1-P3\uff09\u3002\u5176\u4e2d\uff1aP1\u4f9d\u8d56\u4e8e\u6240\u6709\u836f\u7269\u9776\u70b9\uff1bP2\u53bb\u9664\u4e86\u836f\u7269\u9012\u9001\u3001\u4ee3\u8c22\u76f8\u5173\u7684\u86cb\u767d\u8d28\u9776\u70b9\uff0c\u53ef\u4ee5\u63d0\u9ad8\u90bb\u8fd1\u5ea6\u91cf\u7684\u7279\u5f02\u6027\uff1bP3\u6d4b\u8bd5\u836f\u7269\u8bf1\u5bfc\u7684\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u662f\u5426\u53ef\u4ee5\u63d0\u4f9b\u989d\u5916\u7684\u9884\u6d4b\u80fd\u529b [27]\u3002<\/span><\/p>\n


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\u7814\u7a76\u8005\u5b9e\u65bd\u4e86\u4e0a\u9762\u6240\u8ff0\u7684\u5171 12 \u4e2a\u7ba1\u7ebf\uff0c\u6765\u9884\u6d4b DrugBank\u4e2d 6340 \u79cd\u836f\u7269\u5bf9\u65b0\u51a0\u75c5\u6bd2\u7684\u9884\u671f\u7597\u6548 [27] \uff0c\u5e76\u57282020\u5e744\u670815\u65e5\u4ee512\u4e2a\u6392\u540d\u5217\u8868\u7684\u5f62\u5f0f\u63d0\u53d6\u548c\u56fa\u5b9a\u9884\u6d4b\u3002\u7531\u4e8e\u4e0d\u540c\u7684\u7ba1\u7ebf\u6210\u529f\u9884\u6d4b\u4e86\u4e0d\u540c\u7684\u836f\u7269\u5b50\u96c6\uff0c\u4ed6\u4eec\u786e\u5b9a\u4e86\u6240\u6709\u7ba1\u7ebf\u90fd\u63d0\u4f9b\u9884\u6d4b<\/span>\uff08P3\u56e0\u9884\u6d4b\u7684\u836f\u7269\u6570\u91cf\u660e\u663e\u5c11\u800c\u9664\u5916\uff09<\/span>\uff0c\u4e14\u5176\u5316\u5408\u7269\u5728Broad Institute\u8001\u836f\u65b0\u7528\u5e93[28]\u4e2d\u53ef\u7528\u7684918\u79cd\u836f\u7269\u4ea4\u96c6\u8fdb\u884c\u5b9e\u9a8c<\/span>\uff08\u56fe1\uff09<\/span>\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u9996\u5148\uff0c\u4e0a\u8ff0\u9884\u6d4b\u5b8c\u6210\u540e\uff0c\u5bf9\u8fd9918\u79cd\u5316\u5408\u7269\u8fdb\u884c\u4e86\u8bd5\u9a8c\u7b5b\u9009\uff08E918 \u6570\u636e\u96c6\uff09<\/strong>\uff0c\u4ee5\u9a8c\u8bc1\u5b83\u4eec\u5bf9\u65b0\u51a0\u75c5\u6bd2\u7684\u4f53\u5916\u6291\u5236\u6548\u679c<\/span>\uff08\u56fe1\uff09<\/span>\u3002\u5728918\u79cd\u836f\u7269\u4e2d\uff0c806 \u79cd\u5bf9\u75c5\u6bd2\u611f\u67d3\u6027\u6ca1\u6709\u53ef\u68c0\u6d4b\u7684\u5f71\u54cd<\/span>\uff08\u8bb0\u4e3aN\uff0cNo effects\uff09<\/span>\uff1b35\u79cd\u5bf9\u5bbf\u4e3b\u7ec6\u80de\u6709\u7ec6\u80de\u6bd2\u6027<\/span>\uff08\u8bb0\u4e3aC\uff0cCytotoxic\uff09<\/span>\uff1b37\u79cd\u6709\u5f88\u5f3a\u7684\u4f5c\u7528<\/span>\uff08\u8bb0\u4e3aS\uff0cStrong effects\uff09<\/span>\uff1b40\u79cd\u5f71\u54cd\u8f83\u5f31<\/span>\uff08\u8bb0\u4e3aW\uff0cWeak effects\uff09<\/span>\u3002\u7531\u4e8e\u9884\u6d4b\u7ba1\u7ebf\u6ca1\u6709\u5bf9\u4f53\u5185\u6548\u5e94\u7684\u5927\u5c0f\u63d0\u4f9b\u6307\u5bfc\uff0c\u7814\u7a76\u8005\u8ba4\u4e3a\u5bf9\u75c5\u6bd2\u6709\u5f3a\u6216\u5f31\u5f71\u54cd\u7684\u836f\u7269<\/span>\uff08S&W\uff0c77\u79cd\uff09<\/span>\u4e3a\u9633\u6027\u7ed3\u679c\uff0c\u53cd\u4e4b\u5219\u4e3a\u9634\u6027\u7ed3\u679c<\/span>\uff08N\uff0c806\u79cd\uff09<\/span>\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5176\u6b21\uff0c\u57282020\u5e744\u670815\u65e5<\/span>\uff08\u9884\u6d4b\u65e5\u671f\uff09<\/span>\uff0c\u7814\u7a76\u8005\u5728<\/span>134\u9879\u65b0\u51a0\u4e34\u5e8a\u8bd5\u9a8c\uff08CT415 \u6570\u636e\u96c6\uff09<\/span><\/strong><\/span>\u4e2d\u786e\u5b9a\u4e86 67 \u79cd\u836f\u7269\u3002\u4e3a\u4e86\u6bd4\u8f83\u4e0d\u540c\u6570\u636e\u96c6\u7684\u7ed3\u679c\uff0c\u4ed6\u4eec\u5c06\u5206\u6790\u9650\u5236\u5728\u7ecf\u8fc7\u8bd5\u9a8c\u6d4b\u8bd5\u7684 918 \u79cd\u836f\u7269\u4e0a\uff0c\u5c06 E918 \u5217\u8868\u4e0a\u4e34\u5e8a\u8bd5<\/span>\u9a8c\u4e2d\u7684 37 \u79cd\u836f\u7269\u89c6\u4e3a\u9633\u6027\uff0c\u5176\u4f59 881 \u79cd\u89c6\u4e3a\u9634\u6027\u3002<\/span><\/p>\n


<\/span><\/p>\n

<\/p>\n

\u56fe2. 12\u6761\u7ba1\u7ebf\u7684\u9884\u6d4b\u6027\u80fd\u6bd4\u8f83<\/span><\/p>\n


<\/span><\/p>\n

\u8001\u836f\u65b0\u7528\u7684\u76ee\u6807\u662f\u4e3a\u53ef\u7528\u836f\u7269\u6392\u5e8f\uff0c\u5c06\u8bd5<\/span>\u9a8c\u5de5\u4f5c\u4ec5\u9650\u4e8e\u6392\u540d\u9760\u524d\u7684\u5316\u5408\u7269\uff0c\u4ece\u800c\u63d0\u9ad8\u6548\u7387\u548c\u8d44\u6e90\u5229\u7528\u7387\u3002\u5982\u56fe2\u6240\u793a\uff0c\u53ef\u4ee5\u901a\u8fc7AUC\u503c<\/span>\uff08\u53d6\u503c\u8303\u56f4\u4e3a0.5\uff5e1\uff0c\u8d8a\u63a5\u8fd1 1 \u8868\u793a\u8d8a\u51c6\u786e\uff09<\/span>\u3001\u6392\u540d\u524dK\u7684\u836f\u7269\u4e2d\u7684\u9633\u6027\u7ed3\u679c\u6570\u91cf<\/span>\uff08top K \u7cbe\u5ea6\uff09<\/span>\uff0c\u4ee5\u53ca\u5176\u4e2d\u6240\u6709\u9633\u6027\u7ed3\u679c\u7684\u6bd4\u4f8b<\/span>\uff08top K\u53ec\u56de\u7387\uff09<\/span>\u8fd9\u4e09\u4e2a\u6307\u6807\uff0c\u6bd4\u8f8312\u6761\u7ba1\u7ebf\u7684\u9884\u6d4b\u80fd\u529b\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u8fd9\u5c31\u7ed9\u51fa\u4e86\u7b2c\u4e00\u4e2a\u5173\u952e\u7ed3\u679c\u53d1\u73b0\uff0c\u5927\u591a\u6570\u7b97\u6cd5\u5747\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u9884\u6d4b\u80fd\u529b\uff0c\u4f46\u5b83\u4eec\u5728\u4e0d\u540c\u771f\u5b9e\u6570\u636e\u96c6\u4e0a\u6027\u80fd\u6709\u522b\uff1aAI\u7ba1\u7ebf\u64c5\u4e8e\u9009\u62e9CT415\u6570\u636e\u96c6\u7684\u4e34\u5e8a\u8bd5\u9a8c\u836f\u7269\uff0c\u800c\u90bb\u8fd1\u5ea6\u7ba1\u7ebf\u5bf9E918\u6570\u636e\u96c6\u9884\u6d4b\u66f4\u4f73<\/strong>\u3002\u4e0d\u8fc7\uff0c\u867d\u7136\u8fd912\u6761\u7ba1\u7ebf\u4e00\u8d77\u786e\u5b9a\u4e86\u524d 100 \u540d\u4e2d\u7684 22 \u79cd\u9633\u6027\u836f\u7269\uff0c\u4f46\u6ca1\u6709\u4e00\u6761\u7ba1\u7ebf\u4e3a\u6240\u6709\u7ed3\u679c\u63d0\u4f9b\u4e00\u81f4\u7684\u5353\u8d8a\u6027\u80fd\uff0c\u8fd9\u4fc3\u4f7f\u7814\u7a76\u8005\u5f00\u53d1\u4e00\u79cd\u591a\u6a21\u6001\u65b9\u6cd5\uff0c\u4ee5\u96c6\u6210\u6240\u6709\u7ba1\u7ebf\u7684\u9884\u6d4b\u80fd\u529b\u3002<\/span><\/p>\n


<\/span><\/p>\n

 <\/span>
<\/section>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

\u5173\u952e\u53d1\u73b0\u4e8c\uff1a\u4e0d\u540c\u7ba1\u7ebf\u96c6\u6210\uff0c\u9884\u6d4b\u6548\u679c\u4f18\u5f02<\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u8001\u836f\u65b0\u7528\u9884\u6d4b\u6a21\u578b\u7684\u76ee\u6807\uff0c\u662f\u7b5b\u9009\u6709\u9650\u6570\u91cf\uff08K\uff09\u7684\u836f\u7269\u53c2\u4e0e\u5b9e\u9a8c\uff0c\u5e76\u4e14\u6700\u5927\u5316\u79ef\u6781\u7ed3\u679c\u3002\u5728\u6700\u521d\u4e0d\u77e5\u9053\u603b\u5171 Np = 12 \u4e2a\u9884\u6d4b\u7ba1\u7ebf\u4e2d\u7684\u54ea\u4e00\u4e2a\u63d0\u4f9b\u6700\u4f73\u9884\u6d4b\u80fd\u529b\u7684\u60c5\u51b5\u4e0b\uff0c\u7814\u7a76\u8005\u53ef\u4ee5\u4ece\u6bcf\u4e2a\u7ba1\u7ebf\u4e2d\u9009\u62e9\u524d K\/Np \u4e2a\u836f\u7269\uff0c\u6216\u8005\u8ba1\u7b97\u6bcf\u79cd\u836f\u7269\u5728 Np \u7ba1\u7ebf\u4e0a\u7684\u5e73\u5747\u6392\u540d\u3002\u6b64\u5916\uff0c\u6392\u540d\u805a\u5408\u65b9\u6cd5\u5c1d\u8bd5\u641c\u7d22\u4f7f\u6240\u6709\u7ba1\u7ebf\u4e4b\u95f4\u9884\u6d4b\u4e00\u81f4\u6570\u91cf\u6700\u5927\u5316\u7684\u6392\u540d<\/strong>[16,19]\u3002\u8003\u8651\u5230\u6c42\u89e3\u7684\u56f0\u96be\u6027\uff0c\u7814\u7a76\u8005\u5b9e\u65bd\u4e86\u4e09\u79cd\u8fd1\u4f3cKemeny\u5171\u8bc6\u7684\u542f\u53d1\u5f0f\u6392\u540d\u805a\u5408\u7b97\u6cd5\uff1aBorda\u8ba1\u6570\u3001Dowdall\u65b9\u6cd5\u548cCRank[16,29-31]\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u7ed3\u679c\u5982\u56fe3\u6240\u793a\uff0c\u5e73\u5747\u6392\u540d\u7684\u9884\u6d4b\u6027\u80fd\u6700\u5dee\uff0c\u843d\u540e\u4e8e\u5927\u591a\u6570\u5355\u4e2a\u7ba1\u7ebf\u7684\u9884\u6d4b\u80fd\u529b\u3002\u5408\u5e76\u5217\u8868\u548cDowdall\u63d0\u4f9b\u4e86\u66f4\u597d\u7684\u7ed3\u679c\u3002Borda\u5bf9E918\u6709\u5f88\u5f3a\u7684\u9884\u6d4b\u6027\u80fd\uff0c\u4f46\u5bf9CT415\u6ca1\u6709\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u4f9d\u8d56\u8d1d\u53f6\u65af\u56e0\u5b50\u7684CRank\u4e3a\u6240\u6709\u6570\u636e\u96c6\u548c\u5927\u591a\u6570 K \u503c\u63d0\u4f9b\u59cb\u7ec8\u5982\u4e00\u7684\u9ad8\u9884\u6d4b\u6027\u80fd\u3002CRank\u5728\u5176\u4ed6\u4e24\u4e2a\u6570\u636e\u96c6\u4e0a\u8868\u73b0\u540c\u6837\u51fa\u8272\uff1a\u624b\u52a8\u5904\u7406\u7684\u524d\u77bb\u6027\u5217\u8868 E74\u548c2020\u5e746\u670815\u65e5\u66f4\u65b0\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5217\u8868C615\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u7814\u7a76\u8005\u53d1\u73b0\uff0cCRank\u5177\u6709\u7d2f\u79ef\u6027\u5730\u6574\u5408\u6240\u6709\u65b9\u6cd5\u9884\u6d4b\u80fd\u529b\u4e4b\u6f5c\u529b\uff0c\u5728\u6240\u6709\u6570\u636e\u96c6\u4e2d\u5747\u80fd\u8fbe\u5230\u6216\u8d85\u8fc7\u5355\u4e2a\u7ba1\u7ebf\u7684\u9884\u6d4b\u80fd\u529b\u2014\u2014\u8fd9\u662f\u7814\u7a76\u8005\u7684\u7b2c\u4e8c\u4e2a\u5173\u952e\u7ed3\u679c\u3002<\/strong><\/span><\/p>\n


<\/span><\/p>\n

<\/p>\n

\u56fe3. \u5355\u4e2a\u7ba1\u7ebf\u3001\u5e73\u5747\u6392\u540d\u3001\u5408\u5e76\u5217\u8868\uff0c\u4ee5\u53ca\u4e09\u79cd\u6392\u540d\u805a\u5408\u7b97\u6cd5\u7684\u9884\u6d4b\u80fd\u529b\u6bd4\u8f83\u3002CRank\u4e3a\u6240\u6709\u6570\u636e\u96c6\u548c\u5927\u591a\u6570 K \u503c\u63d0\u4f9b\u59cb\u7ec8\u5982\u4e00\u7684\u9ad8\u9884\u6d4b\u6027\u80fd\u3002<\/span><\/p>\n


<\/span><\/p>\n

 <\/span>
<\/section>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

\u5173\u952e\u53d1\u73b0\u4e09\uff1a<\/strong><\/strong><\/p>\n

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\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u76ee\u524d\u836f\u5316\u9886\u57df\uff0c\u5927\u591a\u6570\u8001\u836f\u65b0\u7528\u7b97\u6cd5\u4f9d\u8d56\u4e8e\u5206\u5b50\u5bf9\u63a5\uff0c\u56e0\u6b64\u4ec5\u9650\u4e8e\u4e0e\u75c5\u6bd2\u86cb\u767d\u6216\u75c5\u6bd2\u86cb\u767d\u7684\u5bbf\u4e3b\u9776\u6807\u7ed3\u5408\u7684\u5316\u5408\u7269 [21] \uff0c\u4e00\u4e2a\u5f88\u597d\u7684\u4f8b\u5b50\u662f\u745e\u5fb7\u897f\u97e6*[33, 34]\uff1b\u800c\u672c\u7814\u7a76\u8fd8\u53ef\u4ee5\u8bc6\u522b\u9776\u5411\u5176\u5b83\u5bbf\u4e3b\u86cb\u767d\u8d28\u8bf1\u5bfc\u7f51\u7edc\u6270\u52a8\u800c\u4ea7\u751f\u751f\u7269\u6548\u5e94\u7684\u836f\u7269<\/strong>\uff0c\u5176\u4e2d\u4e00\u4e9b\u53ef\u80fd\u4f1a\u6539\u53d8\u75c5\u6bd2\u80de\u611f\u67d3\u3001\u590d\u5236\u7684\u80fd\u529b<\/span>\uff08\u56fe4\uff09<\/span>\u3002\u5b8c\u6574\u5bbf\u4e3b\u4e2d\u7531\u4e8e\u6f5c\u5728\u7684\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u66f4\u4e30\u5bcc\uff0c\u8fd9\u4e9b\u836f\u7269\u4e5f\u53ef\u80fd\u901a\u8fc7\u5176\u4ed6\u673a\u5236\u53d1\u6325\u4f5c\u7528\uff0c\u4f8b\u5982\u76ae\u8d28\u7c7b\u56fa\u9187\u5982\u5730\u585e\u7c73\u677e[35]\u7684\u6297\u708e\u4f5c\u7528\uff0c\u8fd9\u53ea\u80fd\u5728\u52a8\u7269\u5b9e\u9a8c\u6216\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fdb\u884c\u8bc4\u4f30\u3002<\/span><\/p>\n

\n
\n
*\u6ce8\uff1a\u745e\u5fb7\u897f\u97e6\uff08remdesivir\uff09\u5728\u75ab\u60c5\u521d\u671f\u66fe\u88ab\u8ba4\u4e3a\u5f88\u53ef\u80fd\u6210\u4e3a\u65b0\u51a0\u6cbb\u7597\u7279\u6548\u836f\uff0c\u56fd\u5185\u66fe\u7ffb\u8bd1\u4e3a\u201c\u4eba\u6c11\u7684\u5e0c\u671b\u201d\u3002\u5176\u901a\u8fc7\u76f4\u63a5\u6291\u5236\u75c5\u6bd2RNA\u805a\u5408\u9176\u8d77\u6548\uff0c\u539f\u88ab\u5c1d\u8bd5\u4e8e\u6cbb\u7597\u540c\u4e3aRNA\u75c5\u6bd2\u7684\u57c3\u535a\u62c9\u75c5\u6bd2\uff0c\u4f46\u76ee\u524d\u4e0d\u540c\u4e34\u5e8a\u7ed3\u679c\u5374\u662f\u8912\u8d2c\u4e0d\u4e00\u3002<\/span><\/section>\n<\/section>\n<\/blockquote>\n


<\/p>\n

<\/p>\n

\u56fe4. \u76f4\u63a5\u9776\u5411\u836f\u7269\u6216\u8005\u4e0e\u75c5\u6bd2\u86cb\u767d\uff08D1\uff09\u7ed3\u5408\uff0c\u6216\u8005\u4e0e\u75c5\u6bd2\u86cb\u767d\u7684\u5bbf\u4e3b\u86cb\u767d\u9776\u70b9\uff08D2\uff09\u7ed3\u5408\u3002\u7f51\u7edc\u836f\u7269\uff08D3\uff09\u5219\u53ef\u4ee5\u4e0e\u5176\u5b83\u5bbf\u4e3b\u86cb\u767d\u7ed3\u5408\uff0c\u901a\u8fc7\u8bf1\u5bfc\u7f51\u7edc\u6270\u52a8\u6765\u9650\u5236\u75c5\u6bd2\u6d3b\u6027\u3002<\/span><\/section>\n


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[1] L. Riva et al., Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. Nature 586, 113\u2013119 (2020).<\/span><\/p>\n

[2] J. T. Dudley et al., Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease. Sci. Transl. Med. 3, 96ra76 (2011).<\/span><\/p>\n

[3] M. J. Keiser et al., Predicting new molecular targets for known drugs. Nature 462, 175\u2013181 (2009).<\/span><\/p>\n

[4] M. Campillos, M. Kuhn, A. C. Gavin, L. J. Jensen, P. Bork, Drug target identification using side-effect similarity. Science 321, 263\u2013266 (2008).<\/span><\/p>\n

[5] S. Dakshanamurthy et al., Predicting new indications for approved drugs using a proteochemometric method. J. Med. Chem. 55, 6832\u20136848 (2012).<\/span><\/p>\n

[6] H. Paik et al., Repurpose terbutaline sulfate for amyotrophic lateral sclerosis using electronic medical records. Sci. Rep. 5, 8580 (2015).<\/span><\/p>\n

[7] C. S. Greene, B. F. Voight, Pathway and network-based strategies to translate genetic discoveries into effective therapies. Hum. Mol. Genet. 25, R94\u2013R98 (2016).<\/span><\/p>\n

[8] A. I. Casas et al., From single drug targets to synergistic network pharmacology in ischemic stroke. Proc. Natl. Acad. Sci. U.S.A. 116, 7129\u20137136 (2019).<\/span><\/p>\n

[9] F. Cheng et al., Network-based approach to prediction and population-based validation of in silico drug repurposing. Nat. Commun. 9, 2691 (2018).<\/span><\/p>\n

[10] F. Cheng, I. A. Kov\u00e1cs, A. L. Barab\u00e1si, Network-based prediction of drug combinations. Nat. Commun. 10, 1197 (2019).<\/span><\/p>\n

[11] E. Guney, J. Menche, M. Vidal, A.-L. Bar\u00e1basi, Network-based in silico drug efficacy screening. Nat. Commun. 7, 10331 (2016).<\/span><\/p>\n

[12] S. Sadegh et al., Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing. Nat. Commun. 11, 3518 (2020).<\/span><\/p>\n

[13] Y. Zhou et al., Network-based drug repurposing for novel coronavirus 2019-nCoV\/SARS-CoV-2. Cell Discov. 6, 1\u201318 (2020).<\/span><\/p>\n

[14] M. Zitnik, M. Agrawal, J. Leskovec, Modeling polypharmacy side effects with graph convolutional networks. Bioinformatics 34, i457\u2013i466 (2018).<\/span><\/p>\n

[15] M. Zitnik et al., Machine learning for integrating data in biology and medicine: Principles, practice, and opportunities. Inf. Fusion 50, 71\u201391 (2019).<\/span><\/p>\n

[16] M. Zitnik, R. Sosi\u010d, J. Leskovec, Prioritizing network communities. Nat. Commun. 9, 2544 (2018).<\/span><\/p>\n

[17] M. Cao et al., Going the distance for protein function prediction: A new distance metric for protein interaction networks. PLoS One 8, e76339 (2013).<\/span><\/p>\n

[18] J. J. Patten et al., Multidose evaluation of 6,710 drug repurposing library identifies potent SARS-CoV-2 infection inhibitors in vitro and in vivo. bioRxiv [Preprint] (2021). https:\/\/doi.org\/10.1101\/2021.04.20.440626 (Accessed 22 April 2021).<\/span><\/p>\n

[19] D. Guala, E. L. L. Sonnhammer, A large-scale benchmark of gene prioritization methods. Sci. Rep. 7, 46598 (2017).<\/span><\/p>\n

[20] N. Gulbahce et al., Viral perturbations of host networks reflect disease etiology. PLoS Comput. Biol. 8, e1002531 (2012).<\/span><\/p>\n

[21] D. E. Gordon et al., A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 583, 459\u2013468 (2020).<\/span><\/p>\n

[22] K. Luck, G. M. Sheynkman, I. Zhang, M. Vidal, Proteome-scale human interactomics. Trends Biochem. Sci. 42, 342\u2013354 (2017).<\/span><\/p>\n

[23] M. Caldera, P. Buphamalai, F. M\u00fcller, J. Menche, Interactome-based approaches to human disease. Curr. Opin. Syst. Biol. 3, 88\u201394 (2017).<\/span><\/p>\n

[24] E. K. Silverman et al., Molecular networks in network medicine: Development and applications. Wiley Interdiscip. Rev. Syst. Biol. Med. 12, e1489 (2020).<\/span><\/p>\n

[25] M. Buchanan, G. Caldarelli, P. De Los Rios, F. Rao, M. Vendruscolo, Eds., Networks in Cell Biology, (Cambridge University Press, 2010).<\/span><\/p>\n

[26] J. Menche et al., Disease networks. Uncovering disease-disease relationships through the incomplete interactome. Science 347, 1257601 (2015).<\/span><\/p>\n

[27] D. S. Wishart et al., DrugBank 5.0: A major update to the DrugBank database for 2018. Nucleic Acids Res. 46, D1074\u2013D1082 (2018).<\/span><\/p>\n

[28] S. M. Corsello et al., The drug repurposing hub: A next-generation drug library and information resource. Nat. Med. 23, 405\u2013408 (2017).<\/span><\/p>\n

[29] C. Dwork, R. Kumar, M. Naor, D. Sivakumar, \u201cRank aggregation methods for the web\u201d in Proceedings of the 10th International Conference on World Wide Web, WWW 2001 (Association for Computing Machinery, New York, NY, 2001), pp. 613\u2013622.<\/span><\/p>\n

[30] J. C. de Borda, Memoire sur les elections au scrutin. Histoire de l\u2019Acad\u00e9mie Royale des Sciences 102, 657\u2013665 (1781).<\/span><\/p>\n

[31] B. Reilly, Social choice in the south seas: Electoral innovation and the Borda count in the Pacific Island countries. Int. Polit. Sci. Rev. 23, 355\u2013372 (2002).<\/span><\/p>\n

[32] H. C. May et al., Repurposing auranofin, ebselen, and PX-12 as antimicrobial agents targeting the thioredoxin system. Front. Microbiol. 9, 336 (2018).<\/span><\/p>\n

[33] M. Wang et al., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 30, 269\u2013271 (2020).<\/span><\/p>\n

[34] J. H. Beigel et al., Remdesivir for the treatment of Covid-19\u2014Preliminary report. N.Engl. J. Med. 383, 1813\u20131826 (2020).<\/span><\/p>\n

[35] K. Lin, P. Gallay, Curing a viral infection by targeting the host: The example of cyclophilin inhibitors. Antiviral Res. 99, 68\u201377 (2013).<\/span><\/p>\n


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\u96c6\u667a\u5b66\u56ed\u7279\u9080\u9648\u5173\u8363\u3001\u6a0a\u745b\u3001\u5468\u8fdb\u3001\u674e\u7fd4\u3001\u5f20\u6c5f\u3001\u95eb\u5c0f\u52c7\u3001\u5218\u5b97\u534e\u3001\u77f3\u5ddd\u3001\u865e\u6587\u6b66\u3001\u8d75\u6d77\u5174\u3001\u53f2\u5b9a\u534e\u7b49\u7f51\u7edc\u79d1\u5b66\u4e13\u5bb6\u4f5c\u4e3a\u5bfc\u5e08\uff0c\u81ea10\u670816\u65e5\u8d77\u5f00\u5c55\u7cfb\u5217\u5728\u7ebf\u8bfe\u7a0b\uff0c\u4ecb\u7ecd\u590d\u6742\u7f51\u7edc\u7684\u5efa\u6a21\u4e0e\u5e94\u7528\u4ee5\u53ca\u76f8\u5173\u8bfe\u9898\u3002\u6b22\u8fce\u5e0c\u671b\u8fdb\u5165\u7f51\u7edc\u79d1\u5b66\u9886\u57df\u3001\u63d0\u9ad8\u7f51\u7edc\u5206\u6790\u80fd\u529b\u3001\u4e0e\u4e00\u7ebf\u4e13\u5bb6\u63a2\u8ba8\u95ee\u9898\u7684\u670b\u53cb\u62a5\u540d\u53c2\u52a0\uff01<\/span><\/p>\n


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\u8be6\u60c5\u8bf7\u70b9\u51fb\uff1a<\/span><\/section>\n
\u4ece\u6570\u5b66\u5efa\u6a21\u5230\u591a\u5b66\u79d1\u5e94\u7528\u2014\u2014\u7f51\u7edc\u79d1\u5b66\u00b7\u96c6\u667a\u8bfe\u5802\u5168\u65b0\u5347\u7ea7<\/a><\/span><\/strong><\/span><\/section>\n

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\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n