{"id":30492,"date":"2021-11-30T19:26:58","date_gmt":"2021-11-30T11:26:58","guid":{"rendered":"https:\/\/swarma.org\/?p=30492"},"modified":"2021-11-30T19:26:58","modified_gmt":"2021-11-30T11:26:58","slug":"%e7%bb%86%e8%83%9e%e5%a6%82%e4%bd%95%e8%8e%b7%e5%be%97%e7%a7%a9%e5%ba%8f%ef%bc%9f%e9%99%a4%e4%ba%86%e5%bd%a2%e6%88%90%e7%bb%86%e8%83%9e%e5%99%a8%ef%bc%8c%e8%bf%98%e5%8f%af%e4%bb%a5%e5%8f%91%e7%94%9f","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=30492","title":{"rendered":"\u7ec6\u80de\u5982\u4f55\u83b7\u5f97\u79e9\u5e8f\uff1f\u9664\u4e86\u5f62\u6210\u7ec6\u80de\u5668\uff0c\u8fd8\u53ef\u4ee5\u53d1\u751f\u76f8\u5206\u79bb"},"content":{"rendered":"
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\u7814\u7a76\u9886\u57df\uff1a\u76f8\u5206\u79bb\uff0c\u86cb\u767d\u8d28\u51dd\u805a\uff0c\u5206\u5b50\u96c6\u4f53\u8fd0\u52a8\uff0c\u6d8c\u73b0<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Viviane Callier<\/span> | \u4f5c\u8005<\/strong><\/span><\/strong><\/p>\n

\u738b\u767e\u81fb<\/span> | \u8bd1\u8005<\/strong><\/span><\/strong><\/span><\/p>\n

\u6881\u91d1 <\/span>| \u5ba1\u6821<\/strong><\/span><\/p>\n

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\u6765\u6e90\uff1aDavid McLeod<\/span>
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\u201c\u60f3\u8c61\u4e00\u4e0b\uff1a\u628a\u4e16\u754c\u4e0a\u6240\u6709\u4eba\u90fd\u6324\u8fdb\u72b9\u4ed6\u5dde\u7684\u5927\u76d0\u6e56\u2014\u2014\u6211\u4eec\u6240\u6709\u4eba\u90fd\u80a9\u5e76\u80a9\u6324\u5728\u4e00\u8d77\uff0c\u4f46\u540c\u65f6\u6bcf\u4e2a\u4eba\u53c8\u4ee5\u75af\u72c2\u7684\u901f\u5ea6\u4ece\u53e6\u4e00\u4e2a\u4eba\u8eab\u8fb9\u63a0\u8fc7\u3002\u8fd9\u4e2a\u7c7b\u6bd4\u53ef\u4ee5\u8ba9\u4f60\u5bf9\u4e00\u4e2a\u7ec6\u80de\u4e2d50\u4ebf\u4e2a\u86cb\u767d\u8d28\u5206\u5b50\u5171\u5b58\u7684\u5bc6\u96c6\u7a0b\u5ea6\u6709\u4e00\u4e9b\u4e86\u89e3\u3002\u201d\u82f1\u56fd\u7ec6\u80de\u751f\u7269\u5b66\u5bb6\u3001\u9a6c\u514b\u601d\u00b7\u666e\u6717\u514b\u5206\u5b50\u7ec6\u80de\u751f\u7269\u5b66\u548c\u9057\u4f20\u5b66\u7814\u7a76\u6240\u6240\u957f Anthony Hyman \u4e3e\u4f8b\u8bf4\u3002<\/span><\/p>\n


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\u5728\u62e5\u6324\u7684\u7ec6\u80de\u8d28\u4e2d\uff0c\u4e3a\u4e86\u4fdd\u8bc1\u7ec6\u80de\u7684\u751f\u957f\u3001\u5206\u88c2\u548c\u751f\u5b58\uff0c\u9176\u9700\u8981\u51c6\u786e\u5730\u627e\u5230\u5b83\u4eec\u7684\u5e95\u7269\uff0c\u4fe1\u53f7\u5206\u5b50\u4e5f\u9700\u8981\u540c\u6837\u7cbe\u786e\u5730\u627e\u5230\u5b83\u4eec\u7684\u53d7\u4f53\u3002\u5982\u679c\u7ec6\u80de\u4ec5\u4ec5\u53ea\u662f\u4e00\u4e2a\u88c5\u6ee1\u4e86\u5747\u5300\u7ec6\u80de\u8d28\u7684\u6643\u52a8\u888b\uff0c\u90a3\u8fd9\u4e00\u5207\u5c31\u5f88\u96be\u505a\u5230\uff0c\u4f46\u4e8b\u5b9e\u5e76\u975e\u5982\u6b64\u3002\u6709\u819c\u7684\u7ec6\u80de\u5668\u6709\u52a9\u4e8e\u7ec4\u7ec7\u5185\u5bb9\u7269\uff0c\u6709\u6548\u533a\u9694\u4e00\u7cfb\u5217\u7269\u8d28\uff0c\u8fd8\u80fd\u4e3a\u91cd\u8981\u7684\u751f\u547d\u8fc7\u7a0b\u63d0\u4f9b\u53cd\u5e94\u5f97\u4ee5\u8fdb\u884c\u7684\u751f\u7269\u819c\u8868\u9762<\/strong>\u3002\u8fd9\u7c7b\u8fc7\u7a0b\u7684\u4f8b\u5b50\u6709\u5f88\u591a\uff0c\u6bd4\u5982\u7ec6\u80de\u7684\u751f\u5316\u71c3\u6599ATP\u7684\u5408\u6210\u3002\u4f46\u662f\uff0c\u6b63\u5982\u79d1\u5b66\u5bb6\u4eec\u521a\u521a\u5f00\u59cb\u8ba4\u8bc6\u5230\u7684\u90a3\u6837\uff0c\u7ec6\u80de\u5668\u53ea\u662f\u7ec6\u80de\u79e9\u5e8f\u7684\u4e00\u4e2a\u6765\u6e90\u3002<\/span><\/p>\n


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\u4e3e\u4f8b\u800c\u8a00\uff0c\u51dd\u805a\u7269\u53ef\u4ee5\u89e3\u91ca\u8bb8\u591a\u4e0d\u540c\u7ec6\u80de\u8fc7\u7a0b\u53d1\u751f\u7684\u901f\u5ea6\u3002\u201c\u51dd\u805a\u7269\u7684\u5173\u952e\u5728\u4e8e\uff0c\u5b83\u4e0d\u50cf\u662f\u4e00\u4e2a\u5de5\u5382\uff1b\u76f8\u6bd4\u800c\u8a00\uff0c\u5b83\u66f4\u50cf\u662f\u5feb\u95ea\u65cf<\/span>\uff08flash mob\uff09<\/span>\u3002\u4f60\u6253\u5f00\u6536\u97f3\u673a\uff0c\u6240\u6709\u4eba\u90fd\u805a\u5728\u4e00\u8d77\uff0c\u5f53\u4f60\u628a\u5b83\u5173\u6389\u65f6\uff0c\u6240\u6709\u4eba\u90fd\u6d88\u5931\u4e86\uff0c\u201d Hyman \u8bf4\u3002<\/span><\/p>\n


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\u201c\u6b63\u56e0\u5982\u6b64\uff0c\u8fd9\u79cd\u673a\u5236\u662f\u2018\u53ef\u4ee5\u7cbe\u5fc3\u8c03\u8282\u7684\u2019\u3002\u201d\u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\u548c\u52b3\u4f26\u65af\u00b7\u4f2f\u514b\u5229\u56fd\u5bb6\u5b9e\u9a8c\u5ba4\u7684\u7ec6\u80de\u751f\u7269\u5b66\u5bb6 Gary Karpen \u8bf4\uff0c\u201c\u4ec5\u4ec5\u9700\u8981\u901a\u8fc7\u6539\u53d8\u5206\u5b50\u6d53\u5ea6\uff0c\u5c31\u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u5f62\u6210\u6216\u6eb6\u89e3\u8fd9\u4e9b\u51dd\u805a\u7269\u3002\u201d\u8fd9\u79cd\u96be\u4ee5\u7f6e\u4fe1\u7684\u7cbe\u5ea6\u4e3a\u7ec6\u80de\u63a7\u5236\u5305\u62ec\u57fa\u56e0\u8868\u8fbe\u5728\u5185\u7684\u8bb8\u591a\u751f\u547d\u73b0\u8c61\u63d0\u4f9b\u4e86\u5de5\u5177\u3002<\/span><\/p>\n


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\u56fe1. \u9752\u86d9\u7ec6\u80de\u7684\u6838\u4ec1\u88ab\u67d3\u8272\uff0c\u4ee5\u663e\u793a\u51dd\u805a\u7269\u5185\u7684\u5c0f\u5ba4\u3002\u6838\u4ec1\u662f\u539f\u5b50\u6838\u5185\u6700\u5927\u7684\u7ed3\u6784\uff0c\u662f\u5177\u6709\u5185\u90e8\u7ed3\u6784\u7684\u51dd\u805a\u7269\u3002\u5728\u8fd9\u4e9b\u67d3\u8272\u7684\u86d9\u7ec6\u80de\u6838\u4ec1\u4e2d\uff0c\u4e0d\u540c\u7684\u86cb\u767d\u8d28\u51dd\u805a\u5728\u4e00\u8d77\u3002| \u6765\u6e90\uff1aMarina Feric and Clifford Brangwynne<\/span><\/section>\n


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\u8bc1\u660e\u8fd9\u79cd\u673a\u5236\u5b58\u5728\u7684\u9996\u4e2a\u7ebf\u7d22\u51fa\u73b0\u4e8e2008\u5e74\u590f\u5929\uff0cHyman \u548c\u4ed6\u5f53\u65f6\u7684\u535a\u58eb\u540e Cliff Brangwynne<\/span>\uff08\u73b0\u4efb\u666e\u6797\u65af\u987f\u5927\u5b66\u970d\u534e\u5fb7\u00b7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240\u7814\u7a76\u5458\uff09<\/span>\u6b63\u5728\u5927\u540d\u9f0e\u9f0e\u7684\u6d77\u6d0b\u751f\u7269\u5b9e\u9a8c\u5ba4\u5185\u6559\u5b66\uff0c\u5e76\u7814\u7a76\u79c0\u4e3d\u9690\u6746\u7ebf\u866b\u53d1\u80b2\u4e2d\u7684\u80da\u80ce\u3002\u5f53\u65f6\uff0c\u4ed6\u4eec\u548c\u5b66\u751f\u89c2\u5bdf\u5230\uff0c\u53d7\u7cbe\u5375\u4e2d\u7684RNA\u805a\u96c6\u5f62\u6210\u53ef\u4ee5\u5206\u88c2\u6216\u5f7c\u6b64\u878d\u5408\u7684\u6db2\u6ef4\u3002Hyman\u548c Brangwynne \u5047\u8bbe\uff0c\u8fd9\u4e9b\u201cP\u9897\u7c92\u201d<\/span>\uff08P granule\uff09<\/span>\u662f\u901a\u8fc7\u7ec6\u80de\u8d28\u4e2d\u7684\u76f8\u5206\u79bb<\/span>\uff08phase separation\uff09<\/span>\u5f62\u6210\u7684\uff0c\u5c31\u50cf\u6cb9\u6ef4\u60ac\u6d6e\u5728\u918b\u6c41\u5f53\u4e2d\u4e00\u6837\u3002<\/span><\/p>\n


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\u8fd9\u4e00\u63d0\u8bae\u53d1\u8868\u57282009\u5e74\u7684\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u4e0a\uff0c\u5728\u5f53\u65f6\u5e76\u6ca1\u6709\u5f15\u8d77\u592a\u591a\u7684\u5173\u6ce8\u3002\u4f46\u57282012\u5e74\u5de6\u53f3\uff0c\u66f4\u591a\u5173\u4e8e\u7ec6\u80de\u76f8\u5206\u79bb\u7684\u8bba\u6587\u9646\u7eed\u53d1\u8868\uff0c\u5176\u4e2d\u5305\u62ec\u5fb7\u514b\u8428\u65af\u5927\u5b66 Michael Rosen \u5b9e\u9a8c\u5ba4\u7684\u4e00\u9879\u5173\u952e\u5b9e\u9a8c\uff0c\u8be5\u5b9e\u9a8c\u8868\u660e\uff0c\u7ec6\u80de\u4fe1\u53f7\u86cb\u767d\u4e5f\u53ef\u4ee5\u8868\u73b0\u51fa\u8fd9\u79cd\u76f8\u5206\u79bb\u884c\u4e3a\u3002\u5230\u4e862015\u5e74\uff0c\u76f8\u5173\u7814\u7a76\u7684\u8bba\u6587\u9010\u6e10\u6c47\u6210\u4e00\u80a1\u6d2a\u6d41\uff0c\u4ece\u90a3\u65f6\u8d77\uff0c\u5bf9\u751f\u7269\u5206\u5b50\u51dd\u805a\u7269<\/span>\uff08\u8fd9\u79cd\u6db2\u4f53\u72b6\u7684\u7ec6\u80de\u9694\u95f4\u65e2\u6709\u5f39\u6027\u53c8\u6709\u7c98\u6027\uff09<\/span>\u7684\u7814\u7a76\u53d8\u6210\u4e86\u771f\u6b63\u7684\u70ed\u70b9\u95ee\u9898\u3002<\/span><\/p>\n


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\u73b0\u5728\uff0c\u7ec6\u80de\u751f\u7269\u5b66\u5bb6\u4f3c\u4e4e\u5728\u4ed6\u4eec\u6240\u770b\u5230\u7684\u4efb\u4f55\u5730\u65b9\u90fd\u80fd\u591f\u627e\u5230\u51dd\u805a\u7269\uff1a\u5728\u57fa\u56e0\u8868\u8fbe\u7684\u8c03\u63a7\u3001\u6709\u4e1d\u5206\u88c2\u4e2d\u7eba\u9524\u4f53\u7684\u5f62\u6210\u3001\u6838\u7cd6\u4f53\u7684\u7ec4\u88c5\uff0c\u4ee5\u53ca\u5728\u66f4\u591a\u7ec6\u80de\u6838\u548c\u7ec6\u80de\u8d28\u5185\u53d1\u751f\u7684\u7ec6\u80de\u8fc7\u7a0b\u4e2d\u3002\u8fd9\u4e9b\u51dd\u805a\u7269\u5e76\u4e0d\u53ea\u662f\u4e00\u4e9b\u65b0\u5947\u7684\u73b0\u8c61\uff0c\u5b83\u4eec\u5df2\u7136\u53d8\u5f97\u53d1\u4eba\u6df1\u7701\uff1a\u51dd\u805a\u7269\u7684\u529f\u80fd\u4ece\u5206\u5b50\u7684\u96c6\u4f53\u884c\u4e3a\u5f53\u4e2d\u6d8c\u73b0\u5df2\u6210\u4e3a\u51dd\u805a\u7269\u751f\u7269\u5b66\u7684\u6838\u5fc3\u6982\u5ff5<\/strong>\uff0c\u8fd9\u4e0e\u8ba4\u4e3a\u751f\u5316\u5236\u5242\u548c\u5b83\u4eec\u7684\u9776\u6807\u50cf\u9501\u548c\u94a5\u5319\u4e00\u6837\u76f8\u4e92\u5339\u914d\u7684\u7ecf\u5178\u56fe\u666f\u5f62\u6210\u4e86\u9c9c\u660e\u5bf9\u6bd4\u3002<\/span><\/p>\n


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\u56fe2. \u7ec6\u80de\u4e2d\u7684\u4e00\u4e9b\u751f\u7269\u5206\u5b50\u51dd\u805a\u7269\u3002\u5728\u590d\u6742\u7684\u7ec6\u80de\u4e2d\uff0c\u76f8\u5206\u79bb\u9a71\u52a8\u86cb\u767d\u8d28\u548c\u5176\u4ed6\u5206\u5b50\u5f62\u6210\u6db2\u6001\u51dd\u805a\u7269\uff0c\u53d1\u6325\u591a\u79cd\u591a\u6837\u7684\u751f\u547d\u529f\u80fd\u3002| \u6765\u6e90\uff1aSamuel Velasco\/Quanta Magazine; Source: Salman F. Banani et al.<\/span><\/section>\n


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\u4f46\u662f\u5728\u4e00\u4e9b\u86cb\u767d\u8d28\u94fe\u4e2d\uff0c\u758f\u6c34\u6c28\u57fa\u9178\u76f8\u5bf9\u8f83\u5c11\uff0c\u6240\u4ee5\u5b83\u4eec\u96be\u4ee5\u6298\u53e0\u8d77\u6765\u3002\u76f8\u53cd\uff0c\u8fd9\u4e9b\u5185\u5728\u65e0\u5e8f\u7684\u86cb\u767d\u8d28<\/strong><\/span>\uff08IDPs\uff09<\/span>\u5728\u5f62\u6001\u4e0a\u4e0d\u65ad\u53d1\u751f\u6ce2\u52a8\uff0c\u5e76\u53c2\u4e0e\u8bb8\u591a\u79cd\u5f31\u7684\u591a\u4ef7\u76f8\u4e92\u4f5c\u7528\u3002\u591a\u5e74\u6765\uff0cIDP\u76f8\u4e92\u4f5c\u7528\u88ab\u8ba4\u4e3a\u662f\u5bf9\u7c7b\u6d41\u4f53\u6db2\u6ef4\u884c\u4e3a\u7684\u6700\u4f73\u89e3\u91ca\u3002<\/span><\/p>\n


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\u7136\u800c\u5728\u53bb\u5e74\uff0cBrangwynne\u53d1\u8868\u4e86\u51e0\u7bc7\u8bba\u6587\uff0c\u5f3a\u8c03IDPs\u867d\u7136\u5f88\u91cd\u8981\uff0c\u4f46\u662f\u201c\u8fd9\u4e2a\u9886\u57df\u5728\u5f3a\u8c03IDPs\u7684\u91cd\u8981\u7a0b\u5ea6\u4e0a\u5df2\u7ecf\u8d70\u5f97\u592a\u8fdc\u4e86\u201d\u3002\u4ed6\u8bf4\uff0c\u5927\u591a\u6570\u6d89\u53ca\u51dd\u805a\u7269\u7684\u86cb\u767d\u8d28\u90fd\u6709\u4e00\u4e2a\u5171\u540c\u7684\u7ed3\u6784\u57df\u548c\u4e00\u4e9b\u65e0\u5e8f\u533a\u57df\u3002\u8981\u5f62\u6210\u51dd\u805a\u7269\uff0c\u5206\u5b50\u5fc5\u987b\u4e0e\u5176\u4ed6\u5206\u5b50\u6709\u8bb8\u591a\u5f31\u7684\u591a\u4ef7\u76f8\u4e92\u4f5c\u7528\uff0c\u800c\u6709\u53e6\u4e00\u79cd\u65b9\u6cd5\u53ef\u4ee5\u5b9e\u73b0\u8fd9\u4e00\u70b9\uff1a\u9f50\u805a\u53cd\u5e94<\/span>\uff08oligomerization\uff09<\/span>\u3002<\/span>\uff08\u6ce8\uff1a\u9f50\u805a\u7269\uff08oligomer\uff09\u901a\u5e38\u6307\u5206\u5b50\u91cf\u572810^4\u4ee5\u4e0b\u7684\u4f4e\u805a\u7269\uff0c\u53ef\u51dd\u805a\u5f62\u6210\u9ad8\u805a\u7269\u3002\uff09<\/span><\/p>\n


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\u5f53\u86cb\u767d\u8d28\u76f8\u4e92\u7ed3\u5408\uff0c\u5229\u7528\u91cd\u590d\u7684\u4f4e\u805a\u7269\u5f62\u6210\u66f4\u5927\u7684\u590d\u5408\u7269\u65f6\uff0c\u9f50\u805a\u53cd\u5e94\u5c31\u4f1a\u53d1\u751f\u3002\u968f\u7740\u86cb\u767d\u8d28\u6d53\u5ea6\u589e\u52a0\uff0c\u76f8\u5206\u79bb\u548c\u4f4e\u805a\u7269\u7684\u5f62\u6210\u4e5f\u4f1a\u589e\u52a0\u3002\u572812\u6708\u4e3e\u884c\u7684\u7f8e\u56fd\u7ec6\u80de\u751f\u7269\u5b66\u5b66\u4f1a\u4f1a\u8bae\u4e0a\uff0cBrangwynne\u6307\u51fa\uff0c\u968f\u7740\u4f4e\u805a\u7269\u6d53\u5ea6\u589e\u52a0\uff0c\u5b83\u4eec\u76f8\u4e92\u4f5c\u7528\u7684\u5f3a\u5ea6\u6700\u7ec8\u4f1a\u514b\u670d\u6210\u6838\u58c1\u5792<\/strong><\/span>\uff08\u4e5f\u5c31\u662f\u521b\u9020\u4e00\u4e2a\u8868\u9762\u5c06\u51dd\u805a\u7269\u4e0e\u7ec6\u80de\u8d28\u5176\u4f59\u90e8\u5206\u5206\u79bb\u6240\u9700\u8981\u7684\u80fd\u91cf\uff09<\/span>\uff0c\u5728\u90a3\u65f6\uff0c\u86cb\u767d\u8d28\u4f1a\u628a\u81ea\u5df1\u5305\u542b\u5728\u4e00\u4e2a\u6db2\u6ef4\u4e2d\u3002<\/strong><\/span><\/p>\n


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\u5728\u8fc7\u53bb\u4e94\u5e74\u91cc\uff0c\u7814\u7a76\u4eba\u5458\u5728\u7406\u89e3\u86cb\u767d\u8d28\u7684\u8fd9\u79cd\u96c6\u4f53\u884c\u4e3a\u5982\u4f55\u7531\u5fae\u5c0f\u7684\u7269\u7406\u548c\u5316\u5b66\u529b\u4ea7\u751f\u8fd9\u4e00\u65b9\u9762\u53d6\u5f97\u4e86\u5f88\u5927\u7684\u8fdb\u5c55\uff0c\u4f46\u4ed6\u4eec\u4ecd\u5728\u7814\u7a76\u7ec6\u80de\u5982\u4f55<\/span>\uff08\u4ee5\u53ca\u662f\u5426\uff09<\/span>\u5229\u7528\u8fd9\u79cd\u73b0\u8c61\u8fdb\u884c\u751f\u957f\u548c\u5206\u88c2\u3002<\/span><\/p>\n


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\u56fe3. \u666e\u6797\u65af\u987f\u5927\u5b66\u7684Cliff Brangwynne\u8ba4\u4e3a\uff0c\u51dd\u805a\u7269\u7684\u5f62\u6210\u5f80\u5f80\u662f\u7531\u9f50\u805a\u53cd\u5e94\u9a71\u52a8\u7684\uff0c\u5728\u9f50\u805a\u53cd\u5e94\u8fc7\u7a0b\u4e2d\uff0c\u86cb\u767d\u8d28\u7ed3\u5408\u5728\u4e00\u8d77\uff0c\u5f62\u6210\u5e26\u6709\u91cd\u590d\u4e9a\u57fa\u7684\u5927\u578b\u590d\u5408\u7269\u3002| \u6765\u6e90\uff1aJohn D. and Catherine T. MacArthur Foundation<\/span><\/section>\n


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\u51dd\u805a\u7269\u4f3c\u4e4e\u6d89\u53ca\u5230\u4e86\u7ec6\u80de\u751f\u7269\u5b66\u4e2d\u7684\u8bf8\u591a\u65b9\u9762\uff0c\u4f46\u5176\u4e2d\u53d7\u5230\u7279\u522b\u5173\u6ce8\u7684\u4e00\u4e2a\u9886\u57df\u662f\u57fa\u56e0\u8868\u8fbe\u548c\u86cb\u767d\u8d28\u5408\u6210\u3002<\/span><\/p>\n


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\u6838\u7cd6\u4f53\u662f\u7ec6\u80de\u4e2d\u7684\u86cb\u767d\u8d28\u5236\u9020\u5de5\u5382\uff0c\u7ec6\u80de\u4e2d\u6838\u7cd6\u4f53\u7684\u6570\u91cf\u5f80\u5f80\u9650\u5236\u4e86\u7ec6\u80de\u7684\u751f\u957f\u901f\u5ea6\u3002Brangwynne\u4e0e\u5176\u4ed6\u4eba\u7684\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5feb\u901f\u751f\u957f\u7684\u7ec6\u80de\u53ef\u80fd\u4f1a\u4ece\u7ec6\u80de\u6838\u4e2d\u6700\u5927\u7684\u51dd\u805a\u7269<\/strong>\u2014\u2014\u6838\u4ec1\u4e2d\u5f97\u5230\u4e00\u4e9b\u5e2e\u52a9\u3002\u6838\u4ec1\u901a\u8fc7\u805a\u96c6\u6240\u6709\u5fc5\u9700\u7684\u8f6c\u5f55\u673a\u5236\uff0c\u5305\u62ec\u5236\u9020\u6838\u7cd6\u4f53RNA\u7684\u7279\u5b9a\u9176<\/span>\uff08RNA\u805a\u5408\u9176I\uff09<\/span>\uff0c\u4fc3\u8fdb\u6838\u7cd6\u4f53RNA\u7684\u5feb\u901f\u8f6c\u5f55\u3002<\/span><\/p>\n


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\u56fe4. \u5728\u86d4\u866b\u67d3\u8272\u7684\u7ec4\u7ec7\u4e2d\uff0c\u6838\u4ec1\u4ee5\u7eff\u70b9\u7684\u5f62\u5f0f\u51fa\u73b0\u3002\u6bcf\u4e2a\u7ec6\u80de\uff0c\u4e0d\u8bba\u5927\u5c0f\uff0c\u90fd\u6709\u4e00\u4e2a\u6838\u4ec1\u3002\u8fd1\u5e74\u6765\u7684\u7814\u7a76\u8868\u660e\uff0c\u6838\u4ec1\u7684\u5927\u5c0f\u53d6\u51b3\u4e8e\u7ec6\u80de\u5185\u6838\u4ec1\u86cb\u767d\u7684\u6d53\u5ea6\u3002| \u6765\u6e90\uff1aStephanie Weber<\/span><\/section>\n


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\u51e0\u5e74\u524d\uff0cBrangwynne \u548c\u5f53\u65f6\u8fd8\u5728\u653b\u8bfb\u535a\u58eb\u540e\u7684 Stephanie Weber<\/span>\uff08\u73b0\u4efb\u8499\u7279\u5229\u5c14\u9ea6\u5409\u5c14\u5927\u5b66\u52a9\u7406\u6559\u6388\uff09<\/span>\u7814\u7a76\u4e86\u79c0\u4e3d\u9690\u6746\u7ebf\u866b\u65e9\u671f\u80da\u80ce\u4e2d\u6838\u4ec1\u7684\u5927\u5c0f<\/span>\uff08\u4ee5\u53ca\u76f8\u5e94\u7684\u6838\u7cd6\u4f53RNA\u5408\u6210\u7684\u901f\u5ea6\uff09<\/span>\u662f\u5982\u4f55\u63a7\u5236\u7684\u3002\u7531\u4e8e\u6bcd\u866b\u4e3a\u6bcf\u4e2a\u80da\u80ce\u63d0\u4f9b\u76f8\u540c\u6570\u91cf\u7684\u86cb\u767d\u8d28\uff0c\u6240\u4ee5\u8f83\u5c0f\u80da\u80ce\u7684\u86cb\u767d\u8d28\u6d53\u5ea6\u8f83\u9ad8\uff0c\u5927\u80da\u80ce\u7684\u86cb\u767d\u8d28\u6d53\u5ea6\u8f83\u4f4e\u3002\u6b63\u5982\u7814\u7a76\u4eba\u5458\u57282015\u5e74 Current Biology \u4e2d\u4e00\u7bc7\u8bba\u6587\u4e2d\u6240\u62a5\u9053\u7684\uff0c\u6838\u4ec1\u7684\u5927\u5c0f\u4e0e\u86cb\u767d\u8d28\u6d53\u5ea6\u6709\u5173\uff1a\u5c0f\u7ec6\u80de\u6709\u5927\u6838\u4ec1\uff0c\u5927\u7ec6\u80de\u6709\u5c0f\u6838\u4ec1\u3002<\/strong><\/span><\/p>\n


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Brangwynne\u548cWeber\u53d1\u73b0\uff0c\u901a\u8fc7\u4eba\u5de5\u6539\u53d8\u7ec6\u80de\u5927\u5c0f\uff0c\u53ef\u4ee5\u63d0\u9ad8\u6216\u964d\u4f4e\u86cb\u767d\u8d28\u6d53\u5ea6\uff0c\u4ee5\u53ca\u7531\u6b64\u4ea7\u751f\u7684\u6838\u4ec1\u7684\u5927\u5c0f\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5982\u679c\u628a\u86cb\u767d\u8d28\u6d53\u5ea6\u964d\u4f4e\u5230\u4e34\u754c\u9608\u503c\u4ee5\u4e0b\uff0c\u5c31\u4e0d\u4f1a\u4ea7\u751f\u76f8\u5206\u79bb\u548c\u6838\u4ec1\u3002\u7814\u7a76\u4eba\u5458\u57fa\u4e8e\u51dd\u805a\u7269\u5f62\u6210\u7684\u7269\u7406\u5b66\u63a8\u5bfc\u51fa\u4e86\u4e00\u4e2a\u6570\u5b66\u6a21\u578b\uff0c\u53ef\u4ee5\u51c6\u786e\u9884\u6d4b\u7ec6\u80de\u4e2d\u6838\u4ec1\u7684\u5927\u5c0f\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u73b0\u5728Weber\u6b63\u5728\u5bfb\u627e\u7ec6\u83cc\u4e2d\u7684\u51dd\u805a\u7269\u3002\u7ec6\u83cc\u7684\u7ec6\u80de\u4f53\u66f4\u5c0f\uff0c\u5e76\u4e14\u6ca1\u6709\u819c\u5212\u5206\u51fa\u7684\u533a\u9694\u3002\u201c\u4e5f\u8bb8\u8fd9\u662f\u4e00\u79cd\u66f4\u91cd\u8981\u7684\u533a\u9694\u673a\u5236\uff0c\u56e0\u4e3a\u5b83\u4eec<\/span>\uff08\u7ec6\u83cc\uff09<\/span>\u6ca1\u6709\u5176\u4ed6\u9009\u62e9\uff0c\u201d\u5979\u8bf4\u3002<\/span><\/p>\n


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2020\u5e74\u590f\u5929\uff0cWeber\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\u8868\u660e\uff1a\u5728\u751f\u957f\u7f13\u6162\u7684\u5927\u80a0\u6746\u83cc\u7ec6\u80de\u4e2d\uff0cRNA\u805a\u5408\u9176\u662f\u5747\u5300\u5206\u5e03\u7684\uff1b\u4f46\u5728\u751f\u957f\u8fc5\u901f\u7684\u7ec6\u80de\u4e2d\u4ee5\u6db2\u6ef4\u7684\u5f62\u5f0f\u805a\u96c6\u3002\u5feb\u901f\u751f\u957f\u7684\u7ec6\u80de\u53ef\u80fd\u9700\u8981\u5c06\u805a\u5408\u9176\u96c6\u4e2d\u5728\u6838\u7cd6\u4f53\u57fa\u56e0\u5468\u56f4\uff0c\u4ee5\u6709\u6548\u5408\u6210\u6838\u7cd6\u4f53RNA\u3002<\/span><\/p>\n


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<\/p>\n

\u56fe5. \u5728\u8fd9\u4e00\u7cfb\u5217\u56fe\u50cf\u4e2d\uff0c\u6eb6\u6db2\u4e2d\u7eaf\u5316\u7684\u7ec6\u83cc\u8f6c\u5f55\u56e0\u5b50\u50cf\u6db2\u4f53\u4e00\u6837\u51dd\u7ed3\u6210\u7403\u5f62\u6db2\u6ef4\uff0c\u7136\u540e\u878d\u5408\u5728\u4e00\u8d77\u3002\u7814\u7a76\u4eba\u5458\u6b63\u5728\u7814\u7a76\u8fd9\u4e9b\u51dd\u805a\u7269\u662f\u5426\u80fd\u50cf\u8c03\u8282\u771f\u6838\u7ec6\u80de\u4e00\u6837\u8c03\u8282\u7ec6\u83cc\u7ec6\u80de\u3002| \u6765\u6e90\uff1aJames Wall<\/span><\/section>\n


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Weber\u8bf4\uff1a\u201c\u770b\u8d77\u6765\u76f8\u5206\u79bb\u5728\u751f\u547d\u7684\u6240\u6709\u9886\u57df\u90fd\u5b58\u5728\uff0c\u5b83\u662f\u4e00\u79cd\u666e\u904d\u7684\u673a\u5236\uff0c\u80fd\u591f\u7279\u5f02\u6027\u5730\u5b9e\u73b0\u4e00\u5927\u5806\u4e0d\u540c\u7684\u529f\u80fd<\/strong>\u3002\u201d<\/span><\/p>\n


<\/span><\/p>\n

\u5c3d\u7ba1Weber\u548cBrangwynne\u6307\u51fa\uff0c\u8f6c\u5f55\u6d3b\u8dc3\u5730\u53d1\u751f\u5728\u6838\u4ec1\u8fd9\u4e00\u5927\u578b\u51dd\u805a\u7269\u4e2d\uff0c\u7ec6\u80de\u6838\u4e2d\u7684\u5176\u4ed6\u51dd\u805a\u7269\u5219\u6709\u7740\u76f8\u53cd\u7684\u884c\u4e3a\u3002\u7ec6\u80de\u6838\u4e2d\u7684\u5927\u90e8\u5206DNA\u88ab\u5f52\u7c7b\u4e3a\u5f02\u67d3\u8272\u8d28\uff0c\u56e0\u4e3a\u5b83\u4eec\u66f4\u7d27\u51d1\uff0c\u901a\u5e38\u4e0d\u4f1a\u8868\u8fbe\u751f\u6210\u86cb\u767d\u8d28\u30022017\u5e74\uff0cKarpen\u3001Amy Strom<\/span>\uff08\u5979\u73b0\u5728\u662fBrangwynne\u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u540e\uff09<\/span>\u548c\u4ed6\u4eec\u7684\u540c\u4e8b\u8bc1\u660e\uff0c\u4e00\u79cd\u7279\u5b9a\u7684\u86cb\u767d\u8d28\u4f1a\u7ecf\u5386\u76f8\u5206\u79bb\uff0c\u5728\u679c\u8747\u80da\u80ce\u7684\u5f02\u67d3\u8272\u8d28\u4e0a\u5f62\u6210\u6db2\u6ef4\uff0c\u8fd9\u4e9b\u6db2\u6ef4\u53ef\u4ee5\u76f8\u4e92\u878d\u5408\uff0c\u53ef\u80fd\u63d0\u4f9b\u4e86\u4e00\u79cd\u673a\u5236\u6765\u538b\u7f29\u7ec6\u80de\u6838\u5185\u7684\u5f02\u67d3\u8272\u8d28\u3002<\/span><\/p>\n


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\u56fe6. \u51dd\u805a\u7269\u538b\u7f29\u9057\u4f20\u7269\u8d28\u7684\u673a\u5236\u3002\u6700xin\u65b0\u7814\u7a76\u8868\u660e\uff0c\u51dd\u805a\u7269\u53ef\u80fd\u6709\u52a9\u4e8e\u5bc6\u96c6\u5305\u88c5\u7ec6\u80de\u6838\u4e2d\u7684\u4e00\u4e9b\u67d3\u8272\u8d28\uff0c\u800c\u8fd9\u6709\u53ef\u80fd\u4f1a\u9650\u5236\u67d3\u8272\u8d28\u5185\u6240\u542b\u57fa\u56e0\u7684\u8868\u8fbe\u3002<\/span><\/section>\n
\uff08\u5de6\uff09\u6210\u6838\u3002te\u7279\u5b9a\u86cb\u767d\u8d28\u7c98\u9644\u5728\u67d3\u8272\u8d28\u7684\u4f4d\u70b9\u4e0a\uff0c\u4fc3\u8fdb\u86cb\u767d\u8d28\u805a\u96c6\u4f53\u7684\u751f\u957f\u3002<\/span><\/section>\n
\uff08\u4e2d\uff09\u589e\u957f\u3002\u66f4\u591a\u7684\u86cb\u767d\u8d28\u5f00\u59cb\u805a\u96c6\u5728\u67d3\u8272\u8d28\u4e0a\u86cb\u767d\u8d28\u7684\u5468\u56f4\uff0c\u86cb\u767d\u8d28\u6db2\u6ef4\u5f00\u59cb\u5408\u5e76\u3002<\/span><\/section>\n
\uff08\u53f3\uff09\u6210\u719f\u3002\u4e0d\u65ad\u589e\u957f\u7684\u51dd\u805a\u7269\u5c06\u67d3\u8272\u8d28\u94fe\u62c9\u5728\u4e00\u8d77\uff0c\u4f7f\u5f97\u57fa\u56e0\u7684\u8868\u8fbe\u53d8\u5f97\u60f0\u6027\u3002<\/span><\/section>\n
\u6765\u6e90\uff1aSamuel Velasco\/Quanta Magazine; Source: Amy R. Strom et al.<\/span><\/section>\n


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\u7814\u7a76\u7ed3\u679c\u8fd8\u4e3a\u4e00\u4e2a\u957f\u671f\u5b58\u5728\u7684\u8c1c\u56e2\u63d0\u4f9b\u4e86\u4e00\u4e2a\u4ee4\u4eba\u5174\u594b\u7684\u53ef\u80fd\u89e3\u91ca\u3002\u51e0\u5e74\u524d\uff0c\u9057\u4f20\u5b66\u5bb6\u53d1\u73b0\uff0c\u5982\u679c\u628a\u4e00\u4e2a\u6d3b\u8dc3\u8868\u8fbe\u7684\u57fa\u56e0\u653e\u5728\u5f02\u67d3\u8272\u8d28\u65c1\u8fb9\uff0c\u8fd9\u4e2a\u57fa\u56e0\u5c31\u4f1a\u6c89\u9ed8\uff0c\u5c31\u597d\u50cf\u5f02\u67d3\u8272\u8d28\u72b6\u6001\u5728\u4f20\u64ad\u4e00\u6837\u3002\u201c\u8fd9\u79cd\u4f20\u64ad\u73b0\u8c61\u5f88\u65e9\u5c31\u51fa\u73b0\u4e86\uff0c\u4f46\u6ca1\u6709\u4eba\u771f\u6b63\u7406\u89e3\u5b83\uff0c\u201dKarpen\u8bf4\u3002<\/span><\/p>\n


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\u540e\u6765\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u4e00\u79cd\u53c2\u4e0e\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u7684\u9176\uff0c\u79f0\u4e3a\u7532\u57fa\u8f6c\u79fb\u9176\uff0c\u4ed6\u4eec\u5047\u8bbe\u7532\u57fa\u8f6c\u79fb\u9176\u4f1a\u4ece\u4e00\u4e2a\u7ec4\u86cb\u767d\u8f6c\u79fb\u5230\u4e0b\u4e00\u4e2a\uff0c\u6cbf\u7740DNA\u94fe\u4ece\u5f02\u67d3\u8272\u8d28\u5230\u90bb\u8fd1\u7684\u5e38\u67d3\u8272\u8d28\uff0c\u4e00\u79cd\u201c\u9176\u7684\u52a0\u5de5\u673a\u5236\u201d\uff0cKarpen \u8bf4\u3002\u5728\u8fc7\u53bb20\u5e74\u91cc\uff0c\u8fd9\u4e00\u76f4\u662f\u89e3\u91ca\u8fd9\u79cd\u6269\u6563\u73b0\u8c61\u7684\u4e3b\u8981\u6a21\u578b\u3002\u4f46Karpen\u8ba4\u4e3a\uff0c\u5f02\u67d3\u8272\u8d28\u4e0a\u7684\u51dd\u805a\u7269\u5c31\u50cf\u7ef3\u5b50\u4e0a\u51dd\u7ed3\u7684\u6c34\u73e0\uff0c\u53ef\u80fd\u662f\u4e00\u79cd\u4e0d\u540c\u673a\u5236\u7684\u4ea7\u7269\uff0c\u89e3\u91ca\u4e86\u6c89\u9ed8\u5f02\u67d3\u8272\u8d28\u72b6\u6001\u7684\u6269\u6563\u3002\u201c\u8fd9\u662f\u601d\u8003\u751f\u7269\u5b66\u5982\u4f55\u5de5\u4f5c\u7684\u6839\u672c\u4e0d\u540c\u7684\u65b9\u5f0f\uff0c\u201d\u4ed6\u8bf4\u3002\u4ed6\u73b0\u5728\u6b63\u81f4\u529b\u4e8e\u9a8c\u8bc1\u8fd9\u4e00\u5047\u8bbe\u3002<\/span><\/p>\n


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\u56fe7. \u5728\u8fd9\u4e9b\u679c\u8747\u80da\u80ce\u4e2d\uff0c\u67d3\u8272\u4f53\uff08\u7c89\u7ea2\u8272\uff09\u968f\u7740\u7ec6\u80de\u5206\u88c2\u9010\u6e10\u589e\u539a\u5e76\u5206\u79bb\u3002\u7136\u540e\u5f02\u67d3\u8272\u8d28\u86cb\u767d\uff08\u7eff\u8272\uff09\u5f00\u59cb\u51dd\u7ed3\u6210\u5c0f\u6db2\u6ef4\uff0c\u4e0d\u65ad\u5730\u751f\u957f\u5e76\u878d\u5408\uff0c\u4f3c\u4e4e\u6709\u52a9\u4e8e\u7ec4\u7ec7\u7ec6\u80de\u6240\u4f7f\u7528\u7684\u9057\u4f20\u7269\u8d28\u3002| \u6765\u6e90\uff1aGary Karpen<\/span><\/section>\n


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ATP\u963b\u6b62\u86cb\u767d\u8d28\u51dd\u805a<\/strong><\/strong><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


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\u51dd\u805a\u7269\u8fd8\u6709\u52a9\u4e8e\u89e3\u5f00\u53e6\u4e00\u4e2a\u7ec6\u80de\u4e4b\u8c1c\uff0c\u8fd9\u4e2a\u8c1c\u9898\u5e76\u4e0d\u662f\u85cf\u5728\u7ec6\u80de\u6838\u5185\u90e8\uff0c\u800c\u662f\u53d1\u751f\u4e8e\u7ec6\u80de\u819c\u4e0a\u3002\u5f53\u914d\u4f53\u4e0e\u7ec6\u80de\u8868\u9762\u7684\u53d7\u4f53\u86cb\u767d\u7ed3\u5408\u65f6\uff0c\u4f1a\u5f15\u53d1\u4e00\u8fde\u4e32\u7684\u5206\u5b50\u53d8\u5316\u548c\u8fd0\u52a8\uff0c\u5728\u7ec6\u80de\u8d28\u4e2d\u4f20\u9012\u4fe1\u53f7\u3002\u4f46\u8981\u505a\u5230\u8fd9\u4e00\u70b9\uff0c\u9996\u5148\u5fc5\u987b\u5c06\u673a\u5236\u4e2d\u6240\u6709\u5206\u6563\u5f00\u6765\u7684\u53c2\u4e0e\u8005\u805a\u96c6\u5728\u4e00\u8d77\u3002Lindsay Case\u89e3\u91ca\u8bf4\uff0c\u7814\u7a76\u4eba\u5458\u73b0\u5728\u8ba4\u4e3a\uff1a\u76f8\u5206\u79bb\u53ef\u80fd\u662f\u7ec6\u80de\u7528\u6765\u5728\u819c\u53d7\u4f53\u4e0a\u805a\u96c6\u6240\u9700\u4fe1\u53f7\u5206\u5b50\u7684\u8be1\u8ba1<\/strong>\u3002Lindsay Case\u5728\u7f57\u68ee\u5b9e\u9a8c\u5ba4\u63a5\u53d7\u8fc7\u535a\u58eb\u540e\u8bad\u7ec3\uff0c\u672c\u6708\u5979\u5c06\u5728\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u5f00\u8bbe\u81ea\u5df1\u7684\u5b9e\u9a8c\u5ba4\u3002<\/span><\/p>\n


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Case\u6307\u51fa\uff0c\u901a\u5e38\u7528\u4e8e\u4fe1\u53f7\u8f6c\u5bfc\u7684\u86cb\u767d\u8d28\u4fee\u9970<\/span>\uff08\u5982\u78f7\u9178\u5316\u57fa\u56e2\u7684\u6dfb\u52a0\uff09<\/span>\uff0c\u4f1a\u6539\u53d8\u86cb\u767d\u8d28\u7684\u4ef7\u6001\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u8fd9\u79cd\u4fee\u9970\u4f1a\u6539\u53d8\u5b83\u4e0e\u5176\u4ed6\u5206\u5b50\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u80fd\u529b\u3002\u56e0\u6b64\uff0c\u4fee\u9970\u4e5f\u5f71\u54cd\u86cb\u767d\u8d28\u5f62\u6210\u51dd\u805a\u7269\u7684\u503e\u5411\u3002\u201c<\/span>\u5982\u679c\u4f60\u60f3\u60f3\u7ec6\u80de\u5728\u505a\u4ec0\u4e48\uff0c\u5b83\u5b9e\u9645\u4e0a\u662f\u5728\u8c03\u8282\u8fd9\u4e2a\u5316\u5408\u4ef7\u53c2\u6570\uff0c\u201dCase\u8bf4\u3002<\/span><\/p>\n


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\u51dd\u805a\u7269\u4e5f\u53ef\u80fd\u5728\u8c03\u8282\u548c\u7ec4\u7ec7\u5c0f\u5355\u4f53\u4e9a\u57fa\u805a\u5408\u6210\u86cb\u767d\u4e1d\u65b9\u9762\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002Case\u8bf4\uff1a\u201c\u56e0\u4e3a\u5c06\u5206\u5b50\u805a\u96c6\u5728\u4e00\u8d77\u7684\u65f6\u95f4\u6bd4\u5728\u51dd\u805a\u7269\u4e4b\u5916\u7684\u65f6\u95f4\u66f4\u957f\uff0c\u8fd9\u6709\u5229\u4e8e\u805a\u5408\u3002\u201d\u5728\u5979\u7684\u535a\u58eb\u540e\u7814\u7a76\u4e2d\uff0c\u5979\u53d1\u73b0\u51dd\u805a\u7269\u589e\u5f3a\u4e86\u808c\u52a8\u86cb\u767d\u805a\u5408\u6210\u7ec6\u4e1d\u7684\u8fc7\u7a0b\uff0c\u5e2e\u52a9\u7279\u6b8a\u80be\u7ec6\u80de\u7ef4\u6301\u5176\u4e0d\u5bfb\u5e38\u7684\u5f62\u72b6\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5fae\u7ba1\u86cb\u767d\u7684\u805a\u5408\u5bf9\u5e2e\u52a9\u7ec6\u80de\u6709\u4e1d\u5206\u88c2\u8fc7\u7a0b\u4e2d\u7eba\u9524\u4f53\u7684\u5f62\u6210\u81f3\u4e3a\u5173\u952e<\/span><\/strong>\u300220\u4e16\u7eaa80\u5e74\u4ee3\uff0cHyman\u5728\u5251\u6865\u5927\u5b66\u5206\u5b50\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4\u8fdb\u884c\u7814\u7a76\u751f\u5b66\u4e60\u671f\u95f4\uff0c\u5bf9\u4e86\u89e3\u6709\u4e1d\u5206\u88c2\u7eba\u9524\u4f53\u7684\u5f62\u6210\u4ea7\u751f\u4e86\u5174\u8da3\u3002\u5728\u90a3\u91cc\uff0c\u4ed6\u7814\u7a76\u4e86\u5355\u7ec6\u80de\u79c0\u4e3d\u9690\u6746\u7ebf\u866b\u80da\u80ce\u5728\u5206\u88c2\u6210\u4e24\u4e2a\u7ec6\u80de\u4e4b\u524d\u662f\u5982\u4f55\u5f62\u6210\u6709\u4e1d\u5206\u88c2\u7eba\u9524\u4f53\u7684\u3002\u73b0\u5728\u4ed6\u6b63\u5728\u63a2\u7d22\u51dd\u805a\u7269\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\u6240\u53d1\u6325\u7684\u4f5c\u7528\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5728\u4e00\u9879\u4f53\u5916\u5b9e\u9a8c\u4e2d\uff0cHyman\u548c\u4ed6\u7684\u56e2\u961f\u5236\u9020\u4e86\u5fae\u7ba1\u7ed3\u5408tau\u86cb\u767d\u7684\u6db2\u6ef4\uff0c\u7136\u540e\u52a0\u5165\u5fae\u7ba1\u86cb\u767d\uff0c\u5fae\u7ba1\u86cb\u767d\u4f1a\u8fc1\u79fb\u5230tau\u86cb\u767d\u6db2\u6ef4\u4e2d\u3002\u5f53\u4ed6\u4eec\u5411\u6db2\u6ef4\u4e2d\u52a0\u5165\u6838\u82f7\u9178\u6765\u6a21\u62df\u805a\u5408\u53cd\u5e94\u65f6\uff0c\u5fae\u7ba1\u86cb\u767d\u5355\u4f53\u7ec4\u88c5\u6210\u4e86\u6f02\u4eae\u7684\u5fae\u7ba1\u3002Hyman\u548c\u4ed6\u7684\u540c\u4e8b\u63d0\u51fa\uff0c\u76f8\u5206\u79bb\u53ef\u80fd\u662f\u7ec6\u80de\u542f\u52a8\u5fae\u7ba1\u805a\u5408\u53cd\u5e94\u548c\u6709\u4e1d\u5206\u88c2\u7eba\u9524\u4f53\u5f62\u6210\u7684\u901a\u7528\u65b9\u6cd5\u3002<\/strong><\/span><\/p>\n


<\/span><\/p>\n

tau\u86cb\u767d\u8fd8\u80fd\u4fc3\u4f7f\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u7684\u6807\u5fd7\u6027\u86cb\u767d\u805a\u96c6\u3002\u4e8b\u5b9e\u4e0a\uff0c\u8bb8\u591a\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5<\/strong><\/span>\uff08\u5982\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\u548c\u5e15\u91d1\u68ee\u75c5\uff09<\/span>\u90fd\u6d89\u53ca\u7ec6\u80de\u4e2d\u86cb\u767d\u8d28\u51dd\u805a\u7269\u7684\u9519\u8bef\u5f62\u6210\u3002<\/strong><\/span><\/p>\n


<\/span><\/p>\n

\u4e3a\u4e86\u7814\u7a76\u8fd9\u4e9b\u805a\u96c6\u7269\u662f\u5982\u4f55\u5f62\u6210\u7684\uff0cHyman\u7684\u56e2\u961f\u4e13\u6ce8\u4e8e\u4e00\u79cd\u540d\u4e3aFUS\u7684\u86cb\u767d\u8d28\uff0c\u8fd9\u79cd\u86cb\u767d\u8d28\u5177\u6709\u4e0eALS\u76f8\u5173\u7684\u7a81\u53d8\u5f62\u5f0f\u3002FUS\u86cb\u767d\u901a\u5e38\u4f1a\u5728\u7ec6\u80de\u6838\u4e2d\u88ab\u53d1\u73b0\uff0c\u4f46\u5728\u5e94\u6fc0\u7ec6\u80de\u4e2d\uff0c\u8be5\u86cb\u767d\u79bb\u5f00\u7ec6\u80de\u6838\u8fdb\u5165\u7ec6\u80de\u8d28\uff0c\u5e76\u5728\u90a3\u91cc\u5f62\u6210\u6db2\u6ef4\u3002Hyman\u7684\u56e2\u961f\u53d1\u73b0\uff0c\u5728\u4f53\u5916\u5236\u9020\u53d8\u5f02\u7684FUS\u86cb\u767d\u6db2\u6ef4\u65f6\uff0c\u5927\u7ea68\u5c0f\u65f6\u540e\uff0c\u8fd9\u4e9b\u6db2\u6ef4\u51dd\u56fa\u6210\u201c\u53ef\u6015\u7684\u805a\u96c6\u7269\u201d\u3002\u76f8\u8f83\u4e8e\u6b63\u5e38\u5f62\u5f0f\u7684FUS\u86cb\u767d\uff0c\u8fd9\u79cd\u7a81\u53d8\u86cb\u767d\u62e5\u6709\u5feb\u5f97\u591a\u7684\u6db2\u76f8\u5230\u56fa\u76f8\u7684\u8f6c\u53d8\u901f\u5ea6\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4e5f\u8bb8\u95ee\u9898\u5e76\u4e0d\u5728\u4e8e\uff0c\u4e3a\u4ec0\u4e48\u75be\u75c5\u4e2d\u8fd9\u4e9b\u86cb\u767d\u4f1a\u5f62\u6210\u805a\u96c6\u7269\uff0c\u800c\u662f\u4e3a\u4ec0\u4e48\u5728\u5065\u5eb7\u7ec6\u80de\u4e2d\u8fd9\u4e9b\u86cb\u767d\u4e0d\u4f1a\u805a\u96c6<\/strong>\u3002\u201c\u6211\u5728\u5c0f\u7ec4\u4f1a\u8bae\u4e0a\u7ecf\u5e38\u95ee\u7684\u4e00\u4e2a\u95ee\u9898\u662f\uff1a\u4e3a\u4ec0\u4e48\u7ec6\u80de\u4e0d\u662f\u7092\u9e21\u86cb\uff1f\u201dHyman\u5728\u7ec6\u80de\u751f\u7269\u5b66\u4f1a\u8bae\u4e0a\u8bf4\uff0c\u7ec6\u80de\u8d28\u4e2d\u7684\u86cb\u767d\u8d28\u542b\u91cf\u201c\u975e\u5e38\u6d53\u7f29\uff0c\u5e94\u8be5\u5f88\u5bb9\u6613\u4ece\u6eb6\u6db2\u4e2d\u6790\u51fa\u201d\u3002<\/span><\/p>\n


<\/span><\/p>\n

Hyman \u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u4eba\u5458\u5c06\u7ec6\u80de\u71c3\u6599ATP\u6dfb\u52a0\u5230\u7eaf\u5316\u7684\u5e94\u6fc0\u9897\u7c92<\/span>\uff08stress granule\uff09<\/span>\u86cb\u767d\u51dd\u805a\u7269\u4e2d\uff0c\u5e76\u770b\u5230\u8fd9\u4e9b\u51dd\u805a\u7269\u9010\u6e10\u6d88\u5931\uff0c\u8fd9\u7ed9\u4ed6\u4eec\u63d0\u4f9b\u4e86\u65b0\u7684\u7ebf\u7d22\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u7814\u7a76\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u9e21\u86cb\u6e05\u653e\u5728\u8bd5\u7ba1\u4e2d\uff0c\u5728\u4e00\u6839\u8bd5\u7ba1\u4e2d\u52a0\u5165ATP\uff0c\u5728\u53e6\u4e00\u6839\u8bd5\u7ba1\u4e2d\u52a0\u5165\u76d0\uff0c\u7136\u540e\u52a0\u70ed\u5b83\u4eec\u3002\u76d0\u4e2d\u7684\u9e21\u86cb\u6e05\u9010\u6e10\u805a\u96c6\u8d77\u6765\uff0c\u4f46\u52a0\u5165ATP\u7684\u6ca1\u6709\uff1a\u5728\u6d3b\u7ec6\u80de\u7c7b\u4f3c\u7684\u6d53\u5ea6\u4e0b\uff0cATP\u963b\u6b62\u86cb\u767d\u8d28\u805a\u96c6<\/strong>\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4f46\u8fd9\u4e00\u5207\u7a76\u7adf\u662f\u5982\u4f55\u53d1\u751f\u7684\uff1f\u8fd9\u66fe\u4e00\u76f4\u662f\u4e00\u4e2a\u8c1c\uff0c\u76f4\u5230Hyman\u5728\u73ed\u52a0\u7f57\u5c14\u7684\u4e00\u6b21\u7814\u8ba8\u4f1a\u4e0a\u5076\u7136\u9047\u5230\u4e86\u4e00\u4f4d\u5316\u5b66\u5bb6\u3002\u8fd9\u4f4d\u5316\u5b66\u5bb6\u6307\u51fa\uff0c\u5728\u5de5\u4e1a\u8fc7\u7a0b\u4e2d\uff0c\u88ab\u79f0\u4e3a\u6c34\u6eb6\u52a9\u957f\u5242\u7684\u6dfb\u52a0\u5242\u88ab\u7528\u6765\u589e\u52a0\u758f\u6c34\u5206\u5b50\u7684\u6eb6\u89e3\u5ea6\u3002\u56de\u5230\u5b9e\u9a8c\u5ba4\u540e\uff0cHyman\u548c\u540c\u4e8b\u4eec\u53d1\u73b0ATP\u4f5c\u4e3a\u6c34\u6eb6\u52a9\u957f\u5242\u6709\u5f88\u597d\u7684\u8868\u73b0\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u6709\u8da3\u7684\u662f\uff0cATP\u5728\u7ec6\u80de\u4e2d\u662f\u4e00\u79cd\u975e\u5e38\u4e30\u5bcc\u7684\u4ee3\u8c22\u7269\uff0c\u5178\u578b\u6d53\u5ea6\u4e3a3\uff5e5\u6beb\u6469\u5c14\u3002\u5927\u591a\u6570\u4f7f\u7528ATP\u7684\u9176\u90fd\u80fd\u5728\u4f4e\u4e09\u4e2a\u6570\u91cf\u7ea7\u7684\u6d53\u5ea6\u4e0b\u6709\u6548\u5de5\u4f5c\u3002\u5982\u679c\u4e0d\u9700\u8981ATP\u6765\u9a71\u52a8\u4ee3\u8c22\u53cd\u5e94\uff0c\u4e3a\u4ec0\u4e48ATP\u5728\u7ec6\u80de\u5185\u7684\u6d53\u5ea6\u5982\u6b64\u4e4b\u9ad8\u5462?Hyman\u8ba4\u4e3a\uff0c\u4e00\u79cd\u53ef\u80fd\u7684\u89e3\u91ca\u662f\uff0cATP\u57283\uff5e5\u6beb\u6469\u5c14\u4ee5\u4e0b\u5e76\u4e0d\u8d77\u5230\u6c34\u6eb6\u52a9\u957f\u5242\u7684\u4f5c\u7528\u3002\u4ed6\u8bf4\uff1a\u201c\u4e00\u79cd\u53ef\u80fd\u6027\u662f\uff0c\u5728\u751f\u547d\u8d77\u6e90\u65f6\uff0cATP\u53ef\u80fd\u8fdb\u5316\u6210\u4e00\u79cd\u751f\u7269\u6c34\u6eb6\u52a9\u957f\u5242\uff0c\u8ba9\u751f\u7269\u5206\u5b50\u5728\u9ad8\u6d53\u5ea6\u65f6\u4ecd\u7136\u4fdd\u6301\u6eb6\u89e3\u72b6\u6001\uff0c\u540e\u6765\u624d\u7528\u4f5c\u80fd\u91cf\u6765\u6e90<\/strong>\u3002\u201d<\/span><\/p>\n


<\/span><\/p>\n

Hyman\u627f\u8ba4\uff0c\u8fd9\u4e2a\u5047\u8bbe\u5f88\u96be\u901a\u8fc7\u5b9e\u9a8c\u6765\u9a8c\u8bc1\uff0c\u56e0\u4e3a\u5728\u4e0d\u5f71\u54cdATP\u80fd\u91cf\u529f\u80fd\u7684\u60c5\u51b5\u4e0b\u64cd\u7eb5ATP\u7684\u4eb2\u6c34\u7279\u6027\u975e\u5e38\u6709\u6311\u6218\u6027\u3002\u4f46\u5982\u679c\u8fd9\u4e2a\u60f3\u6cd5\u662f\u6b63\u786e\u7684\uff0c\u53ef\u80fd\u6709\u52a9\u4e8e\u89e3\u91ca\u4e3a\u4ec0\u4e48\u86cb\u767d\u8d28\u805a\u96c6\u901a\u5e38\u4f1a\u5728\u4e0e\u8870\u8001\u6709\u5173\u7684\u75be\u75c5\u4e2d\u5f62\u6210\uff0c\u56e0\u4e3aATP\u7684\u4ea7\u751f\u968f\u7740\u5e74\u9f84\u589e\u957f\u4f1a\u53d8\u5f97\u4f4e\u6548\u3002<\/span><\/p>\n


<\/span><\/p>\n

<\/p>\n

\u56fe8. \u4ece\u86d9\u5375\u7684\u6838\u4ec1\u4e2d\u5206\u79bb\u51fa\u6765\u7684\u4e24\u79cd\u86cb\u767d\u8d28\uff08\u7ea2\u8272\u548c\u9ec4\u8272\uff09\u53ef\u4ee5\u81ea\u53d1\u5730\u7ec4\u7ec7\u6210\u51dd\u6790\u6db2\u6ef4\u3002\u901a\u8fc7\u6539\u53d8\u6eb6\u6db2\u4e2d\u6bcf\u79cd\u86cb\u767d\u8d28\u7684\u6d53\u5ea6\uff0c\u53ef\u4ee5\u4f7f\u5176\u4e2d\u4e00\u79cd\u6216\u4e24\u79cd\u51dd\u6790\u6db2\u751f\u957f\u6216\u6d88\u5931\u3002| \u6765\u6e90\uff1aMarina Feric and Clifford Brangwynne<\/span><\/section>\n


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\u86cb\u767d\u8d28\u51dd\u805a\u5e2e\u52a9\u9002\u5e94\u73af\u5883<\/strong><\/strong><\/p>\n<\/section>\n

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\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\uff0c\u86cb\u767d\u8d28\u805a\u96c6\u663e\u7136\u662f\u6709\u5bb3\u7684\u3002\u4f46\u662f\u4ece\u6db2\u76f8\u5230\u56fa\u76f8\u7684\u8f6c\u53d8\u5728\u5176\u4ed6\u73af\u5883\u4e2d\u53ef\u80fd\u5177\u6709\u9002\u5e94\u6027\u3002<\/span><\/p>\n


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\u8fd9\u4e9b\u4e0d\u786e\u5b9a\u6027\u4e5f\u6ca1\u6709\u8ba9Hyman\u6c14\u9981\u3002\u201c\u9762\u5bf9\u76f8\u5206\u79bb\uff0c\u6bcf\u4e2a\u4eba\u80fd\u505a\u7684\u662f\uff0c\u56de\u5934\u770b\u770b\u90a3\u4e9b\u505c\u6ede\u4e0d\u524d\u7684\u8001\u95ee\u9898\uff0c\u7136\u540e\u60f3\uff1a\u6211\u4eec\u73b0\u5728\u80fd\u4e0d\u80fd\u7528\u4e0d\u540c\u7684\u65b9\u5f0f\u6765\u601d\u8003\u8fd9\u4e2a\u95ee\u9898\uff1f\u6240\u6709\u7684\u7ed3\u6784\u751f\u7269\u5b66\u7814\u7a76\u90fd\u975e\u5e38\u51fa\u8272\uff0c\u4f46\u8bb8\u591a\u95ee\u9898\u9677\u5165\u4e86\u505c\u6ede\uff0c\u4e0d\u80fd\u771f\u6b63\u5730\u89e3\u91ca\u73b0\u5b9e\u3002\u76f8\u5206\u79bb\u6240\u505a\u7684\uff0c\u5c31\u662f\u8ba9\u6bcf\u4e2a\u4eba\u53bb\u91cd\u65b0\u601d\u8003\u8fd9\u4e9b\u95ee\u9898\u3002\u201d<\/span><\/p>\n


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\u539f\u6587\u94fe\u63a5\uff1a<\/span><\/section>\n
https:\/\/www.quantamagazine.org\/molecular-condensates-in-cells-may-hold-keys-to-lifes-regulation-20210107\/<\/span><\/section>\n


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[1] Anthony Hyman et al. Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution\/Condensation. Science Vol 324, 1729-1732 (2009). https:\/\/doi.org\/10.1126\/science.1172046<\/span><\/p>\n

[2] Li, P., Banjade, S., Cheng, HC. et al. Phase transitions in the assembly of multivalent signalling proteins. Nature 483, 336\u2013340 (2012). https:\/\/doi.org\/10.1038\/nature10879<\/span><\/p>\n

[3] Stephanie C. Weber, Clifford P. Brangwynne. Inverse Size Scaling of the Nucleolus by a Concentration-Dependent Phase Transition. Current Biology 25, 641-646 (2015). DOI:https:\/\/doi.org\/10.1016\/j.cub.2015.01.012<\/span><\/p>\n

[4] http:\/\/www.pnas.org\/content\/117\/31\/18540<\/span><\/p>\n

[5] Strom, A., Emelyanov, A., Mir, M. et al. Phase separation drives heterochromatin domain formation. Nature 547, 241\u2013245 (2017). https:\/\/doi.org\/10.1038\/nature22989<\/span><\/p>\n

[6] https:\/\/www.cell.com\/current-biology\/fulltext\/S0960-9822(15)00014-7<\/span><\/p>\n

[7] https:\/\/pubmed.ncbi.nlm.nih.gov\/27471966\/<\/span><\/p>\n

[8] https:\/\/www.cell.com\/molecular-cell\/fulltext\/S1097-2765(20)30046-0<\/span><\/p>\n


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