{"id":31242,"date":"2021-12-22T21:01:34","date_gmt":"2021-12-22T13:01:34","guid":{"rendered":"https:\/\/swarma.org\/?p=31242"},"modified":"2021-12-22T21:01:34","modified_gmt":"2021-12-22T13:01:34","slug":"science%e8%af%84%e8%ae%ba%ef%bc%9a%e6%b7%b1%e5%ba%a6%e5%ad%a6%e4%b9%a0%e5%8a%a9%e5%8a%9b%e9%ab%98%e9%80%9a%e9%87%8f%e7%bb%93%e6%9e%84%e7%94%9f%e7%89%a9%e4%bf%a1%e6%81%af%e5%ad%a6","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=31242","title":{"rendered":"Science\u8bc4\u8bba\uff1a\u6df1\u5ea6\u5b66\u4e60\u52a9\u529b\u9ad8\u901a\u91cf\u7ed3\u6784\u751f\u7269\u4fe1\u606f\u5b66"},"content":{"rendered":"
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J. Pereira & T. Schwede <\/span>| \u4f5c\u8005<\/strong><\/span><\/strong><\/p>\n

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Interactomes in the era of deep learning<\/span><\/span><\/p>\n

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https:\/\/www.science.org\/doi\/10.1126\/science.abm8295<\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n


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1. \u4f20\u7edf\u86cb\u767d\u4e92\u4f5c\u4e0e\u8ba1\u7b97\u5efa\u6a21\u7684\u52a0\u5165<\/strong><\/strong><\/p>\n<\/section>\n

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\u7814\u7a76\u5927\u5206\u5b50\u673a\u5668\u7684\u65b9\u6cd5\u793a\u610f\u56fe\u3002\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u8865\u5145\u4e86\u5b9e\u9a8c\u6280\u672f\uff0c\u5141\u8bb8\u5bf9\u86cb\u767d\u8d28\u7ec4\u88c5\u8fdb\u884c\u5168\u86cb\u767d\u8d28\u7ec4\u7684\u9884\u6d4b\u548c\u5efa\u6a21<\/span><\/section>\n

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\u867d\u7136\u5927\u591a\u6570\u7684\u52aa\u529b\u96c6\u4e2d\u5728\u6539\u9020AlphaFold2\u548cRoseTTAFold\u5de5\u4f5c\u6d41\u7a0b\u4ee5\u6a21\u62df\u5df2\u77e5\u7ec4\u6210\u548c\u5316\u5b66\u8ba1\u91cf\u7684\u86cb\u767d\u8d28\u590d\u5408\u7269[12]\uff0c\u4f46Humphreys\u7b49\u4eba\u5c06RoseTTAFold\u7684\u63a5\u89e6\u9884\u6d4b\u7b97\u6cd5\u7684\u901f\u5ea6\u4e0eAlphaFold2\u6298\u53e0\u5f15\u64ce\u7684\u9ad8\u7cbe\u5ea6\u76f8\u7ed3\u5408\uff0c\u5e76\u63d0\u51fa\u4e86\u4e00\u79cd\u65b0\u65b9\u6cd5\u6765\u540c\u65f6\u51c6\u786e\u9884\u6d4b\u548c\u5efa\u6a21\u9762\u5305\u9175\u6bcd\u83cc\u86cb\u767d\u8d28\u7ec4\u4e2d\u7684\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u5bf9\u2014\u2014\u8fd9\u662f\u7b2c\u4e00\u4e2a\u88ab\u4ee5\u5982\u6b64\u9ad8\u901a\u91cf\u65b9\u5f0f\u5bf9\u5176\u76f8\u4e92\u4f5c\u7528\u8fdb\u884c\u5efa\u6a21\u7684\u771f\u6838\u751f\u7269\u3002Humphreys\u7b49\u4eba\u626b\u63cf\u4e86\u5927\u7ea6800\u4e07\u5bf9\u86cb\u767d\u8d28\uff0c\u6839\u636e\u5f3a\u70c8\u7684\u534f\u540c\u8fdb\u5316\u4fe1\u53f7\u9884\u6d4b\u4e86\u54ea\u4e9b\u86cb\u767d\u8d28\u4e4b\u95f4\u66f4\u53ef\u80fd\u53d1\u8fc7\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u4e14\u901a\u8fc7\u8fde\u63a5\u5bf9\uff08joint pair\uff09\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u53d6\u4ee3\u5927\u5206\u5b50\u8fde\u63a5\uff08macromolecular docking\uff09\uff0c\u4ee5\u6a21\u62df\u7ec4\u88c5\u76843D\u7ed3\u6784<\/strong>\u3002\u8be5\u65b9\u6cd5\u80fd\u591f\u51c6\u786e\u9884\u6d4b1500\u591a\u4e2a\u76f8\u4e92\u4f5c\u7528\u5bf9\u7684\u7ec4\u6210\u5e76\u5bf9\u5176\u7ed3\u6784\u5efa\u6a21\u3002\u8fd9\u4e9b\u76f8\u4e92\u4f5c\u7528\u5bf9\u51e0\u4e4e\u6db5\u76d6\u4e86\u6240\u6709\u5173\u952e\u7684\u771f\u6838\u7ec6\u80de\u8fc7\u7a0b\uff0c\u5305\u62ec106\u79cd\u672a\u88ab\u63cf\u8ff0\u7684\u7ec4\u5408<\/span>\uff08\u53ef\u80fd\u4f1a\u7a81\u663e\u51fa\u6b64\u524d\u672a\u77e5\u7684\u751f\u7269\u8fc7\u7a0b\uff09<\/span>\uff0c\u4ee5\u53ca600\u591a\u4e2a\u6b64\u524d\u5df2\u77e5\u7684\u76f8\u4e92\u4f5c\u7528\u5bf9<\/span>\uff08\u6839\u636e\u4f4e\u5206\u8fa8\u7387\u751f\u7269\u7269\u7406\u6570\u636e\uff09<\/span>\u3002<\/span><\/p>\n

 <\/span><\/p>\n

Humphreys\u7b49\u4eba\u7684\u5de5\u4f5c\u5411\u9ad8\u5206\u8fa8\u7387\u7684\u6574\u4e2a\u7ec6\u80de\u6a21\u578b\u8fc8\u8fdb\u4e86\u4e00\u6b65\uff0c\u5e76\u4e14\u5df2\u7ecf\u542f\u53d1\u4e86\u5bf9\u4eba\u7c7b\u7ebf\u7c92\u4f53\u76f8\u4e92\u4f5c\u7528\u7684\u8fdb\u4e00\u6b65\u7814\u7a76[13]\u3002\u76ee\u524d\uff0c\u5982\u9ad8\u5206\u5b50\u7ed3\u6676\u548c\u7535\u5b50\u663e\u5fae\u955c<\/span>\uff08EM\uff09<\/span>\u65b9\u6cd5\u53ef\u4ee5\u63d0\u4f9b\u5355\u4e2a\u5927\u5206\u5b50\u673a\u5668\u7684\u9ad8\u5206\u8fa8\u7387\u539f\u5b50\u8868\u793a\u3002\u7ec6\u80de\u4f4e\u6e29\u7535\u5b50\u65ad\u5c42\u6210\u50cf\u6709\u53ef\u80fd\u63d0\u4f9b\u5927\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u7684\u8be6\u7ec6\u5feb\u7167\uff0c\u4f46\u8fc4\u4eca\u4e3a\u6b62\u53ea\u80fd\u83b7\u5f97\u4e9a\u7eb3\u7c73\u5206\u8fa8\u7387[14]\u3002\u57fa\u4e8e\u4eba\u5de5\u667a\u80fd\u7684\u9ad8\u7cbe\u5ea6\u86cb\u767d\u8d28\u7ec4\u76f8\u4e92\u4f5c\u7528\u6a21\u578b\uff0c\u53ef\u80fd\u80fd\u591f\u53ca\u65f6\u5f25\u8865\u5206\u8fa8\u7387\u5dee\u8ddd\u2014\u2014\u5c24\u5176\u662f\u5bf9\u4e8e\u66f4\u590d\u6742\u7684\u751f\u7269\u4f53\u3002\u5c3d\u7ba1\u5982\u6b64\uff0cAlphaFold2\u548cRoseTTAFold\u7b49\u65b9\u6cd5\u63d0\u4f9b\u4e86\u9759\u6001\u6a21\u578b\uff0c\u672a\u6765\u8fd8\u9700\u8981\u89e3\u51b3\u5927\u5206\u5b50\u7ec4\u88c5\u7684\u77ac\u6001\u548c\u52a8\u6001\u7279\u6027\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u8fd9\u9879\u5de5\u4f5c\u8fd8\u7a81\u51fa\u4e86\u5f00\u653e\u79d1\u5b66\u548c\u57fa\u4e8e\u793e\u533a\u7684\u65b9\u6cd5\u5f00\u53d1\u7684\u6210\u529f\u3002\u7531\u4e00\u5bb6\u5546\u4e1a\u516c\u53f8\u5f00\u53d1\u7684AlphaFold2\uff0c\u5411\u8fd9\u4e2a\u79d1\u5b66\u793e\u533a\u516c\u5f00\u6a21\u578b\u53ca\u5176\u6e90\u4ee3\u7801\u3002\u8fd9\u4fc3\u8fdb\u4e86\u4e0d\u540c\u76ee\u6807\u57fa\u4e8eAI\u7684\u751f\u7269\u4fe1\u606f\u5b66\u65b9\u6cd5\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u4f8b\u5982Humphreys\u7b49\u4eba\u7684\u7814\u7a76\u3002\u57fa\u4e8e\u4eba\u5de5\u667a\u80fd\u65b9\u6cd5\u663e\u7136\u6b63\u5728\u4fc3\u8fdb\u672a\u6765\u751f\u547d\u79d1\u5b66\u7814\u7a76\u65b9\u5f0f\u7684\u8f6c\u53d8\uff0c\u5176\u4e2d3D\u8ba1\u7b97\u6a21\u578b\u5c06\u7ecf\u5e38\u6fc0\u53d1\u65b0\u7684\u53ef\u5b9e\u9a8c\u9a8c\u8bc1\u7684\u5047\u8bf4\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u53c2\u8003\u6587\u732e<\/span><\/strong><\/span><\/p>\n

1. I. R. Humphreys et al., Science 374, eabm4805 (2021).  <\/span><\/p>\n

2. A. N. Lupas et al., Biochem. J. 478, 1885 (2021).  <\/span><\/p>\n

3. S. M. Kandathil, J. G. Greener, D. T. Jones, Proteins 87, 1179 (2019).  <\/span><\/p>\n

4. T. Nakane et al., Nature 587, 152 (2020).  <\/span><\/p>\n

5. A. Sali, J. Biol. Chem. 296, 100743 (2021).  <\/span><\/p>\n

6. J. Jumper et al., Nature 596, 583 (2021).  <\/span><\/p>\n

7. A. Kryshtafovych et al., Proteins 89, 1607 (2021).  <\/span><\/p>\n

8. Q. Cong et al., Science 365, 185 (2019).  <\/span><\/p>\n

9. A. G. Green et al., Nat. Commun. 12, 1396 (2021).  <\/span><\/p>\n

10. J. Pereira et al., Proteins 89, 1687 (2021).  <\/span><\/p>\n

11. M. Baek et al., Science 373, 871 (2021).  <\/span><\/p>\n

12. R. Evans et al., bioRxiv 10.1101\/2021.10.04.463034 (2021).  <\/span><\/p>\n

13. J. Pei et al., bioRxiv 10.1101\/2021.09.14.460228 (2021).  <\/span><\/p>\n

14. M. Turk, W. Baumeister, FEBS Lett. 594, 3243 (2020). <\/span><\/p>\n

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\u590d\u6742\u79d1\u5b66\u6700\u65b0\u8bba\u6587<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u96c6\u667a\u6591\u56fe\u9876\u520a\u8bba\u6587\u901f\u9012\u680f\u76ee\u4e0a\u7ebf\u4ee5\u6765\uff0c\u6301\u7eed\u6536\u5f55\u6765\u81eaNature\u3001Science<\/span>\u7b49\u9876\u520a\u7684\u6700\u65b0\u8bba\u6587\uff0c\u8ffd\u8e2a\u590d\u6742\u7cfb\u7edf\u3001\u7f51\u7edc\u79d1\u5b66\u3001\u8ba1\u7b97\u793e\u4f1a\u79d1\u5b66\u7b49\u9886\u57df\u7684\u524d\u6cbf\u8fdb\u5c55\u3002\u73b0\u5728\u6b63\u5f0f\u63a8\u51fa\u8ba2\u9605\u529f\u80fd\uff0c\u6bcf\u5468\u901a\u8fc7\u5fae\u4fe1\u670d\u52a1\u53f7\u300c\u96c6\u667a\u6591\u56fe\u300d\u63a8\u9001\u8bba\u6587\u4fe1\u606f\u3002\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\u5373\u53ef\u4e00\u952e\u8ba2\u9605\uff1a<\/span>
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\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n