{"id":32164,"date":"2022-01-28T22:52:08","date_gmt":"2022-01-28T14:52:08","guid":{"rendered":"https:\/\/swarma.org\/?p=32164"},"modified":"2022-01-28T22:52:08","modified_gmt":"2022-01-28T14:52:08","slug":"%e6%96%b0%e5%86%a0%e5%8f%98%e4%bd%93%e4%b8%ba%e4%bd%95%e5%b1%82%e5%87%ba%e4%b8%8d%e7%a9%b7%ef%bc%9f%e9%80%82%e5%ba%94%e5%ba%a6%e6%99%af%e8%a7%82%e5%88%bb%e7%94%bb%e7%97%85%e6%af%92%e6%bc%94%e5%8c%96","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=32164","title":{"rendered":"\u65b0\u51a0\u53d8\u4f53\u4e3a\u4f55\u5c42\u51fa\u4e0d\u7a77\uff1f\u9002\u5e94\u5ea6\u666f\u89c2\u523b\u753b\u75c5\u6bd2\u6f14\u5316\u4e4b\u8def"},"content":{"rendered":"<div class='wxsyncmain'>\n<section style=\"font-size: 16px;\" data-mpa-powered-by=\"yiban.io\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(63, 63, 63);font-family: PingFangSC-light;font-size: 15px;background-color: rgb(255, 255, 255);\">\n<section style=\"outline: 0px;display: inline-block;width: 661px;vertical-align: top;background-color: rgb(246, 246, 246);\">\n<section style=\"outline: 0px;\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" class=\"rich_pages wxw-img\" data-backh=\"325\" data-backw=\"578\" data-ratio=\"0.5625\"  data-type=\"png\" data-w=\"1920\" height=\"auto\" style=\"font-size: 16px;white-space: normal;width: 100%;height: auto;\" width=\"2880\" src=\"\/wp-content\/uploads\/2022\/01\/wxsync-2022-01-be8adc57321570bb7aaacc2ad3a675da.png\"  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;outline: 0px;letter-spacing: 0.544px;\">\n<section style=\"outline: 0px;width: 661px;\">\n<section style=\"padding-right: 3px;outline: 0px;float: left;line-height: 1;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;text-align: left;\">\n<section style=\"padding-left: 10px;outline: 0px;display: inline-block;width: auto;vertical-align: top;min-width: 10%;height: auto;border-left: 3px solid rgb(33, 166, 210);border-bottom-left-radius: 0px;line-height: 0;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;transform: translate3d(-13px, 0px, 0px);\">\n<section style=\"outline: 0px;display: inline-block;width: 25px;height: 10px;vertical-align: top;overflow: hidden;line-height: 0;border-style: solid solid none;border-width: 3px 3px 2px;border-radius: 0px;border-color: rgb(33, 166, 210) rgb(33, 166, 210) rgb(15, 76, 129);\"><br style=\"outline: 0px;\"  \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;transform: translate3d(-1px, 0px, 0px);\">\n<section style=\"outline: 0px;text-align: justify;color: rgb(33, 166, 210);font-size: 16px;line-height: 1.5;\">\n<p style=\"outline: 0px;\"><strong style=\"outline: 0px;\">\u5bfc\u8bed<\/strong><\/p>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;transform: translate3d(-13px, 0px, 0px) rotateX(180deg);\">\n<section style=\"outline: 0px;display: inline-block;width: 24px;height: 10px;vertical-align: top;overflow: hidden;line-height: 0;border-style: solid solid none;border-width: 3px 3px 2px;border-radius: 0px;border-color: rgb(33, 166, 210) rgb(33, 166, 210) rgb(15, 76, 129);\"><br style=\"outline: 0px;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 4px;padding-left: 4px;outline: 0px;clear: right;box-shadow: rgb(0, 0, 0) 0px 0px 0px;min-height: 4.5em !important;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 5px;margin-bottom: 5px;outline: 0px;\">\n<section style=\"padding-right: 8px;padding-left: 8px;outline: 0px;font-size: 13px;line-height: 2;letter-spacing: 0.544px;\">\n<p style=\"outline: 0px;clear: none;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><\/strong><span style=\"font-size: 13px;\"><strong><span style=\"letter-spacing: 0.544px;color: rgb(63, 63, 63);\">\u65b0\u51a0\u75ab\u60c5\u597d\u4f3c\u4e00\u573a\u4e16\u754c\u5927\u6218\uff0c\u75c5\u6bd2\u6f14\u5316\u4e0e\u4eba\u7c7b\u6297\u75ab\u624b\u6bb5\u7684\u53d1\u5c55\u5728\u4e0a\u6f14\u4e00\u51fa\u7279\u522b\u7684\u519b\u5907\u7ade\u8d5b\u3002Alpha\u3001Beta\u3001Delta\u4ee5\u53ca\u6700\u65b0\u7684Omicron\u53d8\u5f02\u6bd2\u682a\u4e0d\u65ad\u51b2\u51fb\u7740\u4eba\u7c7b\u7684\u6297\u75ab\u6218\u7ebf\u3002\u9762\u5bf9\u5982\u6b64\u6218\u51b5\uff0c\u6211\u4eec\u5982\u4f55\u628a\u63e1\u4e3b\u52a8\uff1f\u662f\u5426\u6709\u53ef\u80fd\u9884\u6d4b\u65b0\u51a0\u75c5\u6bd2\u7684\u6f14\u5316\uff1fFred Hutchinson \u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u501f\u52a9\u6df1\u5ea6\u7a81\u53d8\u626b\u63cf\u6280\u672f\uff0c\u52fe\u7ed8\u51fa\u51a0\u72b6\u75c5\u6bd2\u523a\u7a81\u86cb\u767d\u4e2d\u53d7\u4f53\u7ed3\u5408\u533a\u7684\u9002\u5e94\u5ea6\u666f\u89c2\uff0c\u5c1d\u8bd5\u7406\u89e3\u75c5\u6bd2\u5982\u4f55\u901a\u8fc7\u6f14\u5316\u52a0\u5f3a\u4f20\u67d3\u6027\u5e76\u8eb2\u907f\u514d\u75ab\u7cfb\u7edf\u7684\u4fa6\u5bdf\uff0c\u4ee5\u6b64\u4e3a\u540e\u7eed\u75ab\u82d7\u7684\u7814\u53d1\u6307\u660e\u9053\u8def\u3002<\/span><\/strong><\/span><\/p>\n<p style=\"outline: 0px;clear: none;\"><strong><span style=\"letter-spacing: 0.544px;\"><br  \/><\/span><\/strong><\/p>\n<p style=\"outline: 0px;clear: none;\"><strong style=\"outline: 0px;\"><span style=\"outline: 0px;letter-spacing: 0.544px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><span style=\"outline: 0px;letter-spacing: 0.544px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><span style=\"outline: 0px;letter-spacing: 0.544px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><strong style=\"outline: 0px;color: rgb(0, 0, 0);text-align: start;\">\u7814\u7a76\u9886\u57df\uff1a<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><span style=\"font-size: 13px;\"><strong style=\"outline: 0px;\"><span style=\"outline: 0px;letter-spacing: 0.544px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><span style=\"outline: 0px;letter-spacing: 0.544px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><span style=\"outline: 0px;letter-spacing: 0.544px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><strong style=\"outline: 0px;color: rgb(0, 0, 0);text-align: start;\">\u4f20\u67d3\u75c5\uff0c\u9002\u5e94\u5ea6\u666f\u89c2\uff0c\u534f\u540c\u6f14\u5316<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;outline: 0px;\">\n<section style=\"outline: 0px;width: 661px;\">\n<section style=\"outline: 0px;clear: both;line-height: 0;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(63, 63, 63);font-family: PingFangSC-light;font-size: 15px;background-color: rgb(255, 255, 255);text-align: center;\">\n<section style=\"outline: 0px;vertical-align: middle;display: inline-block;line-height: 0;\"><img class=\"rich_pages wxw-img\" data-fileid=\"100098753\" data-ratio=\"0.07314814814814814\"  data-type=\"png\" data-w=\"1080\" style=\"outline: 0px;box-sizing: border-box;vertical-align: middle;visibility: visible !important;width: 677px !important;height: auto !important;\" src=\"\/wp-content\/uploads\/2022\/01\/wxsync-2022-01-e16cd5b776e38a4f6806c73548bdc7d4.png\"  \/><strong style=\"outline: 0px;letter-spacing: 0.544px;text-align: right;font-size: 13px;color: rgb(0, 0, 0);\"><\/strong><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 0pt;margin-bottom: 0pt;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(73, 73, 73);line-height: 1.7;font-size: 11pt;font-family: PingFangSC-light;background-color: rgb(255, 255, 255);text-align: right;\">\n<p style=\"outline: 0px;\"><span style=\"letter-spacing: 0.544px;font-size: 13px;\">Carrie Arnold<\/span><span style=\"font-size: 16px;letter-spacing: 0.544px;\">&nbsp;<\/span><span style=\"letter-spacing: 0.544px;outline: 0px;font-size: 13px;\"><strong style=\"outline: 0px;color: rgb(0, 0, 0);\">| \u4f5c\u8005<\/strong><\/span><\/p>\n<h3 data-reactid=\"268\" style=\"white-space: normal;\"><\/h3>\n<p style=\"outline: 0px;\"><span style=\"letter-spacing: 0.544px;outline: 0px;color: rgb(63, 63, 63);font-size: 13px;\">\u8d75\u96e8\u4ead<\/span><span style=\"letter-spacing: 0.544px;outline: 0px;font-size: 13px;\"><strong style=\"outline: 0px;color: rgb(0, 0, 0);\"><span style=\"color: rgb(73, 73, 73);font-family: PingFangSC-light;letter-spacing: 0.544px;text-align: right;background-color: rgb(255, 255, 255);font-size: 16px;\">&nbsp;<\/span><span style=\"color: rgb(73, 73, 73);font-family: PingFangSC-light;letter-spacing: 0.544px;text-align: right;background-color: rgb(255, 255, 255);outline: 0px;\"><strong style=\"outline: 0px;color: rgb(0, 0, 0);\">| \u8bd1\u8005<\/strong><\/span><\/strong><\/span><\/p>\n<p style=\"outline: 0px;\"><span style=\"letter-spacing: 0.544px;outline: 0px;color: rgb(63, 63, 63);font-size: 13px;\">\u5f20\u6fb3\u3001\u6881\u91d1<\/span><span style=\"letter-spacing: 0.544px;outline: 0px;font-size: 13px;\"><strong style=\"outline: 0px;color: rgb(0, 0, 0);\"><span style=\"color: rgb(73, 73, 73);font-family: PingFangSC-light;letter-spacing: 0.544px;text-align: right;background-color: rgb(255, 255, 255);font-size: 16px;\">&nbsp;<\/span><span style=\"color: rgb(73, 73, 73);font-family: PingFangSC-light;letter-spacing: 0.544px;text-align: right;background-color: rgb(255, 255, 255);outline: 0px;\"><strong style=\"outline: 0px;color: rgb(0, 0, 0);\">| \u5ba1\u6821<\/strong><\/span><\/strong><\/span><\/p>\n<p style=\"outline: 0px;\"><span style=\"letter-spacing: 0.544px;outline: 0px;color: rgb(63, 63, 63);font-size: 13px;\">\u9093\u4e00\u96ea<\/span><span style=\"letter-spacing: 0.544px;outline: 0px;font-size: 13px;\"><strong style=\"outline: 0px;color: rgb(0, 0, 0);\">&nbsp;| \u7f16\u8f91<\/strong><\/span><br  \/><\/p>\n<p style=\"outline: 0px;\"><br  \/><\/p>\n<\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/p>\n<h3 style=\"outline: 0px;white-space: normal;letter-spacing: 0.544px;font-family: -apple-system, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;font-family: PingFangSC-light;text-align: right;font-size: 13px;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;letter-spacing: 0.544px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;line-height: 1.75em;\">\n<section style=\"outline: 0px;display: inline-block;vertical-align: middle;\">\n<section style=\"margin-bottom: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;clear: both;line-height: 0;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;border-left: 3px solid rgb(33, 166, 210);border-right: 3px solid rgb(33, 166, 210);border-top-color: rgb(33, 166, 210);border-bottom-color: rgb(33, 166, 210);font-size: 16px;color: rgb(0, 0, 0);line-height: 1.4;\">\n<p style=\"outline: 0px;\"><strong style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\">1. \u5982\u4f55\u9884\u6d4b\u75c5\u6bd2\u6f14\u5316\uff1f<\/strong><\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<section style=\"margin-right: 8px;margin-left: 8px;outline: 0px;font-size: 16px;white-space: normal;line-height: 1.75em;\"><br  \/><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">2019 \u5e74\u79cb\u51ac\uff0c\u73b0\u4ee3\u5386\u53f2\u4e0a\u6700\u5927\u7684\u4e00\u573a\u6f14\u5316\u751f\u7269\u5b66\u5b9e\u9a8c\u5f00\u59cb\u4e86\u3002\u4e00\u79cd\u51a0\u72b6\u75c5\u6bd2\u83b7\u5f97\u4e86\u751f\u6d3b\u5728\u4eba\u7c7b\u4f53\u5185\u800c\u975e\u8759\u8760\u6216\u5176\u4ed6\u54fa\u4e73\u52a8\u7269\u4f53\u5185\u7684\u80fd\u529b\uff0c\u5b83\u8fdb\u4e00\u6b65\u9002\u5e94\u4ee5\u9ad8\u6548\u5730\u4ece\u4e00\u4e2a\u4eba\u4f20\u64ad\u5230\u53e6\u4e00\u4e2a\u4eba\uff0c\u751a\u81f3\u5728\u8eab\u4f53\u7684\u9632\u5fa1\u80fd\u529b\u542f\u52a8\u4e4b\u524d\u5c31\u5f00\u59cb\u4f20\u64ad\u3002\u4f46\u75c5\u6bd2\u7684\u6f14\u5316\u6e38\u620f\u5e76\u6ca1\u6709\u5c31\u6b64\u505c\u6b62\uff0c\u7814\u7a76\u4eba\u5458\u4e0d\u5f97\u4e0d\u7528\u4e00\u4e2a\u4e2a\u5e0c\u814a\u5b57\u6bcd\u6765\u547d\u540d SARS-CoV-2 \u7684\u65b0\u53d8\u79cd\u3002<\/span><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u4e16\u754c\u5404\u5730\u7684\u7814\u7a76\u4eba\u5458\u6b63\u8bd5\u56fe\u66f4\u8be6\u7ec6\u5730\u4e86\u89e3\u75c5\u6bd2\u7684\u6f14\u5316\u8fc7\u7a0b\uff0c\u7279\u522b\u662f SARS-CoV-2 \u7684\u7a81\u53d8\u5982\u4f55\u6539\u53d8\u5176\u5728\u4eba\u7c7b\u4e4b\u95f4\u4f20\u64ad\u7684\u80fd\u529b\u3002\u201c\u4eca\u5929\u9002\u5e94\u826f\u597d\u7684\u75c5\u6bd2\u660e\u5929\u53ef\u80fd\u4f1a\u56e0\u4e3a\u5bbf\u4e3b\u4ea7\u751f\u6297\u836f\u6027\u800c\u9010\u6e10\u6d88\u4ea1\uff0c\u6240\u4ee5\u75c5\u6bd2\u5fc5\u987b\u627e\u5230\u4e00\u79cd\u65b0\u7684\u65b9\u6cd5\u6765\u611f\u67d3\u5bbf\u4e3b\u3002\u8fd9\u63a8\u52a8\u4e86\u81ea\u6211\u63d0\u5347\u7684\u66f4\u65b0\u3002\u201d\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u7684\u6f14\u5316\u751f\u7269\u5b66\u5bb6 Justin Meyer \u8868\u793a\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5c3d\u7ba1\u4e0d\u65ad\u53d8\u5316\u7684\u75ab\u60c5\u9020\u6210\u4e86\u5927\u91cf\u4eba\u5458\u4f24\u4ea1\uff0c\u4f46\u89c2\u5bdf\u75c5\u6bd2\u5728\u5168\u7403\u8303\u56f4\u5185\u4f20\u64ad\u7684\u5927\u91cf\u79d1\u5b66\u6570\u636e\u5177\u6709\u6307\u5bfc\u610f\u4e49\u3002\u725b\u6d25\u5927\u5b66\u5927\u6570\u636e\u7814\u7a76\u6240\u7684\u7edf\u8ba1\u9057\u4f20\u5b66\u5bb6 Luca Ferretti \u8868\u793a\uff0cCOVID \u4e3a\u7814\u7a76\u4eba\u5458\u63d0\u4f9b\u4e86\u73cd\u8d35\u7684\u6f14\u5316\u5b9e\u4f8b\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u51c6\u786e\u9884\u6d4b\u75c5\u6bd2\u4e0b\u4e00\u6b65\u7684\u53d1\u5c55\u662f\u75f4\u5fc3\u5984\u60f3\uff0c\u4f46\u4e16\u754c\u5404\u5730\u7684\u75c5\u6bd2\u5b66\u5bb6\u4e00\u76f4\u5728\u6df1\u5165\u7814\u7a76 SARS-CoV-2 \u4e2d\u54ea\u4e9b\u6210\u5206\u6700\u5bb9\u6613\u6f14\u5316\uff0c\u54ea\u4e9b\u5173\u952e\u86cb\u767d\u8d28\u5143\u7d20\u7684\u6539\u53d8\u4f1a\u5f71\u54cd\u5176\u751f\u5b58 [1]\u3002\u8fd9\u4e9b\u4fe1\u606f\u53ef\u4ee5\u4e3a\u7814\u53d1\u66f4\u597d\u3001\u66f4\u6301\u4e45\u7684\u75ab\u82d7\u6307\u660e\u9053\u8def\u3002\u5176\u5b83\u7814\u7a76\u5219\u805a\u7126\u4e8e\u75c5\u6bd2\u5bf9\u5355\u514b\u9686\u6297\u4f53\u7597\u6cd5<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08monoclonal antibody therapies\uff0c\u4e00\u79cd\u6cbb\u7597\u65b0\u51a0\u91cd\u75c7\u60a3\u8005\u7684\u7597\u6cd5\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u4ea7\u751f\u8010\u836f\u6027\u7684\u65b9\u5f0f[2]\u3002\u8fd9\u9879\u5de5\u4f5c\u8fd8\u6307\u51fa\uff0c\u7279\u5b9a\u53d8\u4f53\u7ec4\u5408\u4e00\u65e6\u5e7f\u6cdb\u4f20\u64ad\uff0c\u5c31\u53ef\u80fd\u5f15\u53d1\u65b0\u4e00\u8f6e\u75ab\u60c5\u3002\u8fd9\u4e9b\u53d8\u4f53\u9664\u4e86\u4f20\u64ad\u901f\u5ea6\u5feb\u4e4b\u5916\uff0c\u8fd8\u5c24\u4e3a\u64c5\u957f\u653b\u51fb\u4eba\u4f53\u7684\u514d\u75ab\u7cfb\u7edf[3]\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u80fd\u591f\u901a\u8fc7\u4f7f\u7528\u73b0\u4ee3\u6280\u672f\u91cd\u65b0\u5ba1\u89c6\u8fd1\u4e00\u4e2a\u4e16\u7eaa\u524d\u63d0\u51fa\u7684\u6982\u5ff5\u2014\u2014<strong>\u9002\u5e94\u5ea6\u666f\u89c2<\/strong><\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08fitness\/adaptive landscape\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u2014\u2014\u6765\u505a\u51fa\u4ee5\u4e0a\u53d1\u73b0\u3002\u4ed6\u4eec\u53ef\u4ee5\u7528\u9002\u5e94\u5ea6\u6765<strong>\u91cf\u5316\u75c5\u6bd2\u57fa\u56e0\u7ec4\u53d8\u5316\u4e0e\u5176\u590d\u5236\u548c\u611f\u67d3\u65b0\u5bbf\u4e3b\u80fd\u529b\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u4ee3\u8868\u8fd9\u79cd\u5173\u7cfb\u7684\u666f\u89c2\u56fe\u53ef\u4ee5\u5e2e\u52a9\u91cd\u5efa\u75c5\u6bd2\u7684\u5386\u53f2\uff0c\u751a\u81f3\u8fd8\u53ef\u4ee5\u9884\u6d4b\u75c5\u6bd2\u7684\u672a\u6765<\/strong>\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5bf9\u4e8e\u4f26\u6566\u5e1d\u56fd\u7406\u5de5\u5b66\u9662\u7684\u5206\u5b50\u6f14\u5316\u751f\u7269\u5b66\u5bb6 Tobias Warnecke \u6765\u8bf4\uff0c\u9002\u5e94\u5ea6\u666f\u89c2\u662f\u5c06\u57fa\u56e0\u578b\u4e0e\u8868\u578b\u8054\u7cfb\u8d77\u6765\u7684\u5b9d\u8d35\u65b9\u5f0f\u3002\u4ed6\u8868\u793a\uff0c\u901a\u8fc7\u5b9a\u91cf\u53d1\u6398\u57fa\u56e0\u7684\u6f5c\u529b\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u63a2\u7d22\u4e24\u4e2a\u7a81\u53d8\u5982\u4f55\u5171\u540c\u5f71\u54cd\u4e00\u4e2a\u6027\u72b6\uff0c\u4ee5\u53ca\u7b2c\u4e09\u4e2a\u7a81\u53d8\u7684\u5b58\u5728\u5982\u4f55\u5f71\u54cd\u8fd9\u4e24\u4e2a\u7a81\u53d8\u3002\u201c\u901a\u8fc7\u8fd9\u79cd\u65b9\u5f0f\uff0c\u53ef\u4ee5\u67e5\u770b\u8bb8\u591a\u4e0d\u540c\u7684\u57fa\u56e0\u578b\u7ec4\u5408\uff0c\u770b\u770b\u5b83\u5982\u4f55\u5f71\u54cd\u81ea\u5df1\u611f\u5174\u8da3\u7684\u4e1c\u897f\u3002\u201d<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u9002\u5e94\u5ea6\u666f\u89c2\u7684\u4ef7\u503c\u4e0d\u4ec5\u9650\u4e8e\u6bd4\u8f83\u57fa\u56e0\u7ec4\u6216\u86cb\u767d\u8d28\u7684\u5c11\u91cf\u53d8\u5316\u3002\u73b0\u4ee3\u5b9e\u9a8c\u6280\u672f\u5f00\u53d1\u4e86\u4e00\u79cd\u79f0\u4e3a<strong>\u6df1\u5ea6\u7a81\u53d8\u626b\u63cf<\/strong><\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08deep mutational scanning\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7684\u6280\u672f\uff0c\u5229\u7528\u8be5\u6280\u672f\uff0c\u7814\u7a76\u4eba\u5458\u80fd\u591f<strong>\u5bf9\u81ea\u7136\u9009\u62e9\u8fdb\u884c\u5c0f\u89c4\u6a21\u5b9e\u9a8c\uff0c\u5e76\u540c\u65f6\u6bd4\u8f83\u6570\u4e07\u4e2a\u7a81\u53d8\u7684\u9002\u5e94\u5ea6<\/strong>\u3002\u8be5\u8fc7\u7a0b\u53ef\u80fd\u6709\u52a9\u4e8e\u63ed\u793a\u75c5\u6bd2\u53d8\u4f53\u95f4\u65e0\u6cd5\u9884\u6599\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u4e14\u5c1d\u8bd5\u627e\u51fa\u53ef\u80fd\u5bf9\u4eba\u7c7b\u6784\u6210\u65b0\u5a01\u80c1\u7684\u75c5\u6bd2\u672a\u6765\u6f14\u5316\u7684\u8def\u5f84\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><span style=\"color: rgb(63, 63, 63);font-size: 15px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<h3 style=\"outline: 0px;white-space: normal;letter-spacing: 0.544px;font-family: -apple-system, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;font-family: PingFangSC-light;text-align: right;font-size: 13px;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;letter-spacing: 0.544px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;line-height: 1.75em;\">\n<section style=\"outline: 0px;display: inline-block;vertical-align: middle;\">\n<section style=\"margin-bottom: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;clear: both;line-height: 0;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;border-left: 3px solid rgb(33, 166, 210);border-right: 3px solid rgb(33, 166, 210);border-top-color: rgb(33, 166, 210);border-bottom-color: rgb(33, 166, 210);font-size: 16px;color: rgb(0, 0, 0);line-height: 1.4;\">\n<p style=\"outline: 0px;\"><strong style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\">2. \u9002\u5e94\u5ea6\u666f\u89c2\uff1a\u751f\u5b58\u7684\u52a8\u6001\u5730\u56fe<\/strong><\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<section style=\"margin-right: 8px;margin-left: 8px;outline: 0px;font-size: 16px;white-space: normal;line-height: 1.75em;\"><br  \/><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5728\u300a\u7269\u79cd\u8d77\u6e90\u300b\u4e2d\uff0c\u67e5\u5c14\u65af\u00b7\u8fbe\u5c14\u6587\u5199\u9053\uff0c\u81ea\u7136\u9009\u62e9\u662f\u201c\u4fdd\u6301\u6709\u5229\u7684\u4e2a\u4f53\u5dee\u5f02\u548c\u53d8\u5f02\uff0c\u6d88\u706d\u6709\u5bb3\u7684\u4e2a\u4f53\u5dee\u5f02\u548c\u53d8\u5f02\u201d\u7684\u7ed3\u679c\u3002\u5728\u57fa\u56e0\u7684\u6982\u5ff5\u51fa\u73b0\u4e4b\u524d\uff0c\u751f\u7269\u5b66\u5bb6\u53ea\u80fd\u8bd5\u56fe\u60f3\u8c61\u6709\u673a\u4f53\u5fae\u5c0f\u3001\u53ef\u9057\u4f20\u7684\u53d8\u5316\u5982\u4f55\u5f71\u54cd\u7e41\u6b96\u3002\u7f8e\u56fd\u751f\u7269\u5b66\u5bb6 Sewall Wright \u7684\u5de5\u4f5c\u9996\u6b21\u5b9e\u73b0\u4e86\u8be5\u60f3\u6cd5\u3002\u57281932 \u7684\u300a\u7b2c\u516d\u5c4a\u56fd\u9645\u9057\u4f20\u5b66\u5927\u4f1a\u8bba\u6587\u96c6\u300b\u4e0a\u53d1\u8868\u7684\u8bba\u6587\u4e2d\uff0cWright \u5f00\u521b\u6027\u5730\u4f7f\u7528\u624b\u7ed8\u56fe\u6765\u8868\u660e\u6709\u673a\u4f53\u5982\u4f55\u7a7f\u68ad\u4e8e\u201c\u51e0\u4e4e\u65e0\u9650\u5927\u7684\u53ef\u80fd\u53d8\u5f02\u9886\u57df\uff0c\u5e76\u5728\u81ea\u7136\u9009\u62e9\u4e0b\u627e\u5230\u751f\u5b58\u4e4b\u8def\u201d\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Wright \u6307\u51fa\uff0c\u53ef\u89c6\u5316\u5927\u91cf\u53ef\u80fd\u7684\u7ebf\u6027\u5206\u5b50<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u5982 DNA \u6216\u80bd\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u53d8\u4f53\u7684\u4e00\u79cd\u65b9\u6cd5\uff0c\u662f\u5c06\u6bcf\u79cd\u53ef\u80fd\u6027\u89c6\u4e3a\u7a7a\u95f4\u4e2d\u4e00\u4e2a\u7279\u5b9a\u7684\u70b9\u3002\u5206\u5b50\u6f14\u5316\u5373\u4e3a\u521d\u59cb\u53d8\u4f53\u70b9\u548c\u6700\u7ec8\u53d8\u4f53\u70b9\u4e4b\u95f4\u7684\u8def\u5f84\uff0c\u8be5\u8def\u5f84\u9014\u7ecf\u4e2d\u95f4\u53d8\u4f53\u7684\u6240\u6709\u70b9\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u4e3a\u4e86\u5e2e\u52a9\u7406\u89e3\u8fd9\u4e9b\u53d8\u4f53\u7684\u590d\u6742\u56fe\u5f62\u4ee5\u53ca\u5b83\u4eec\u4e4b\u95f4\u7684\u6f14\u5316\u8def\u5f84\uff0cWright \u5c06\u5176\u8868\u793a\u4e3a\u66f4\u76f4\u89c2\u7684\u4ec5\u6709\u4e24\u4e2a\u6216\u4e09\u4e2a\u7ef4\u5ea6\u7684\u201c\u9002\u5e94\u5ea6\u666f\u89c2\u201d\u3002\u5e73\u9762\u8f74\u7ed8\u5236 DNA<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u57fa\u56e0\u578b\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u6216\u7269\u7406\u7279\u5f81<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u8868\u578b\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7684\u53d8\u5f02\uff1b\u4e24\u4e2a\u53d8\u4f53\u8d8a\u76f8\u4f3c\uff0c\u5b83\u4eec\u5728\u5e73\u9762\u4e0a\u7684\u4f4d\u7f6e\u5c31\u8d8a\u8fd1\u3002\u7eb5\u8f74\u8861\u91cf\u53d8\u5f02\u5bf9\u6f14\u5316\u9002\u5e94\u5ea6\u7684\u5f71\u54cd\u3002\u63d0\u9ad8\u751f\u7269\u4f53\u5b58\u6d3b\u51e0\u7387\u7684\u53d8\u4f53\uff0c\u65e0\u8bba\u662f\u901a\u8fc7\u589e\u52a0\u5176\u5b58\u6d3b\u540e\u4ee3\u8fd8\u662f\u6539\u5584\u5176\u86cb\u767d\u8d28\u7684\u529f\u80fd\uff0c\u5747\u96c6\u4e2d\u5728\u9002\u5e94\u5ea6\u666f\u89c2\u7684\u9ad8\u5cf0\uff0c\u800c\u964d\u4f4e\u751f\u7269\u4f53\u5b58\u6d3b\u51e0\u7387\u7684\u53d8\u5f02\u5219\u88ab\u56f0\u5728\u5c71\u8c37\u4e2d\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><img loading=\"lazy\" class=\"rich_pages wxw-img\" data-backh=\"426\" data-backw=\"562\" data-ratio=\"0.7587209302325582\"  data-type=\"png\" data-w=\"1720\" height=\"auto\" style=\"width: 100%;height: auto;\" width=\"1720\" src=\"\/wp-content\/uploads\/2022\/01\/wxsync-2022-01-226fb59f47f507b3469c9401bc26b057.png\"  \/><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.5em;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">\u56fe1. Sewall Wright \u4e3a\u5176 1932 \u5e74\u7684\u5f00\u521b\u6027\u8bba\u6587\u7ed8\u5236\u7684\u4e00\u5e45\u63d2\u56fe\uff0c\u4ee3\u8868\u4e86\u9002\u5e94\u5ea6\u666f\u89c2\u53ef\u80fd\u7684\u6a21\u6837\u3002\u8be5\u5e73\u9762\u4ee3\u8868\u6240\u6709\u53ef\u80fd\u53d8\u4f53\u7684\u96c6\u5408\u3002\u5176\u4e2d\u865a\u7ebf\u8868\u793a\u5177\u6709\u76f8\u4f3c\u9002\u5e94\u5ea6\u7684\u53d8\u4f53\uff0c\u52a0\u53f7\u8868\u793a\u666f\u89c2\u7684\u9ad8\u5cf0\uff0c\u51cf\u53f7\u8868\u793a\u666f\u89c2\u7684\u5c71\u8c37\u3002| \u6765\u6e90\uff1aThe University of Chicago Library and permissions granted from Genetics Society of America<\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5bc6\u6b47\u6839\u5927\u5b66\u533b\u5b66\u9662\u7684\u6f14\u5316\u751f\u7269\u5b66\u5bb6 Adam Lauring \u89e3\u91ca\uff0c\u7531\u6b64\u4ea7\u751f\u7684\u666f\u89c2\u5177\u6709\u72ec\u7279\u7684\u62d3\u6251\u3002\u5982\u679c\u6620\u5c04\u7684\u53d8\u4f53\u5bf9\u9002\u5e94\u5ea6\u7684\u5f71\u54cd\u6ca1\u6709\u592a\u5927\u5dee\u5f02\uff0c\u90a3\u4e48\u666f\u89c2\u770b\u8d77\u6765\u5c31\u50cf\u5e73\u539f\u4e00\u6837\u5e73\u5766\u3002\u5bf9\u4eba\u7c7b\u5065\u5eb7\u5f71\u54cd\u5de8\u5927\u7684\u53d8\u4f53\u5219\u5728\u666f\u89c2\u4e2d\u521b\u9020\u4e86\u7c7b\u4f3c\u73e0\u7a46\u6717\u739b\u5cf0\u4e00\u6837\u7684\u9ad8\u5cf0\u3002\u81ea\u7136\u9009\u62e9\u504f\u7231\u9ad8\u5cf0\u6240\u5bf9\u5e94\u7684\u53d8\u4f53\uff1a\u7269\u79cd\u5e73\u5747\u57fa\u56e0\u578b\u6216\u8868\u578b\u5e94\u8be5\u901a\u8fc7\u5728\u9ad8\u5cf0\u95f4\u79fb\u52a8\u6765\u6f14\u5316\uff0c\u5e76\u4e14\u6f14\u5316\u6700\u597d\u662f\u6cbf\u7740\u9ad8\u5cf0\u95f4\u7684\u5c71\u810a\u800c\u975e\u7a7f\u8fc7\u5c71\u8c37\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u5177\u6709\u4e0d\u540c\u57fa\u56e0\u578b\u7684\u5b64\u7acb\u4e9a\u7fa4\u4e5f\u53ef\u4ee5\u5e2e\u52a9\u4e00\u4e2a\u7269\u79cd\u627e\u5230\u8de8\u8d8a\u9e3f\u6c9f\u7684\u65b9\u5f0f\u3002\uff09<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><br  \/><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u201c\u5982\u679c\u4f60\u79fb\u52a8\u51e0\u82f1\u5c3a\uff0c\u5c31\u4f1a\u6454\u5012\uff0c\u518d\u6b21\u7ad9\u8d77\u6765\u4f1a\u53d8\u5f97\u975e\u5e38\u56f0\u96be\uff0c\u79fb\u52a8\u7684\u9014\u5f84\u4f1a\u8d8a\u6765\u8d8a\u5c11\u3002\u201dLauring\u8868\u793a\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u201c\u8fd9\u4e2a\u7406\u8bba\u975e\u5e38\u7b80\u5355\u3002\u7814\u7a76\u4eba\u5458\u53ea\u9700\u8981\u77e5\u9053\u7269\u79cd\u7684\u57fa\u56e0\u578b\uff0c\u7136\u540e\u6d4b\u91cf\u5176\u5bf9\u5e94\u7684\u9002\u5e94\u5ea6\uff0c\u4fbf\u53ef\u4ee5\u9884\u6d4b\u4efb\u4f55\u53ef\u80fd\u53d1\u751f\u7684\u4e8b\u60c5\u3002\u201d\u5728\u745e\u58eb\u4f2f\u5c14\u5c3c\u5927\u5b66\u7814\u7a76\u6f14\u5316\u52a8\u529b\u5b66\u7684 Claudia Bank \u8868\u793a\u3002\u4f46\u5c06\u7406\u8bba\u4ed8\u8bf8\u5b9e\u8df5\u5c31\u662f\u53e6\u4e00\u56de\u4e8b\u4e86\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u4e00\u4e2a\u590d\u6742\u7684\u95ee\u9898\u662f\uff0c\u65e0\u8bba\u662f\u9488\u5bf9 SARS-CoV-2 \u8fd8\u662f\u4eba\u7c7b\uff0c<strong>\u9002\u5e94\u5ea6\u666f\u89c2\u90fd\u4e0d\u662f\u4e00\u6210\u4e0d\u53d8\u7684<\/strong>\u3002\u5bf9\u4e8e\u751f\u7269\u4f53\u800c\u8a00\uff0c\u4e00\u79cd\u80fd\u591f\u4f7f\u5176\u6d88\u5316\u65b0\u98df\u7269\u3001\u4f46\u540c\u65f6\u4e5f\u964d\u4f4e\u751f\u957f\u901f\u5ea6\u7684\u53d8\u5f02\uff0c\u65e2\u53ef\u80fd\u662f\u6551\u547d\u7a3b\u8349\uff0c\u4e5f\u53ef\u80fd\u662f\u81f4\u547d\u969c\u788d\u3002\u53d8\u5f02\u5bf9\u6f14\u5316\u9002\u5e94\u5ea6\u7684\u5f71\u54cd\u53d6\u51b3\u4e8e\u751f\u7269\u4f53\u6240\u5904\u7684\u73af\u5883\u3002\u5f53\u73af\u5883\u53d1\u751f\u53d8\u5316\u65f6\uff0c\u9002\u5e94\u5ea6\u666f\u89c2\u4e5f\u4f1a\u53d1\u751f\u53d8\u5316\u3002\u201c\u4e0d\u540c\u7684\u53d8\u5f02\u5f71\u54cd\u4e0d\u540c\uff0c\u8fd9\u53d6\u51b3\u4e8e\u751f\u7269\u4f53\u5f53\u524d\u7684\u73af\u5883\u3002\u201d Lauring\u8868\u793a\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><span style=\"text-align: center;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><\/span><\/section>\n<section style=\"text-align: center;margin-left: 8px;margin-right: 8px;\"><img class=\"rich_pages wxw-img js_insertlocalimg\" data-backh=\"230\" data-backw=\"537\" data-ratio=\"0.42830540037243947\" data-s=\"300,640\"  data-type=\"gif\" data-w=\"537\" style=\"width: 100%;height: auto;\" src=\"\/wp-content\/uploads\/2022\/01\/wxsync-2022-01-79cf6803abf167e4dd97f2b138b99ef2.gif\"  \/><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.5em;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">\u56fe2. \u7531\u4e8e\u73af\u5883\u4e0d\u65ad\u53d8\u5316\uff0c\u9002\u5e94\u5ea6\u666f\u89c2\u4e5f\u603b\u662f\u5728\u4e0d\u65ad\u53d8\u5316\u3002\u751f\u7269\u79cd\u7fa4\u8ffd\u968f\u9ad8\u5cf0\u800c\u6f14\u5316\u3002| \u6765\u6e90\uff1aRandy Olson &amp; Bj\u00f8rn \u00d8stman<\/span><br  \/><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7ed8\u5236\u9002\u5e94\u5ea6\u666f\u89c2\u4e5f\u662f\u4e00\u4e2a\u6570\u5b66\u6311\u6218<\/span><\/strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u3002\u957f\u5ea6\u53ea\u6709 100 \u4e2a\u6c28\u57fa\u9178\u7684\u5c0f\u86cb\u767d\u8d28\u4f1a\u6709 20<sup>100<\/sup> \u79cd\u53ef\u80fd\u7684\u53d8\u4f53\u2014\u2014\u6bd4\u5b87\u5b99\u4e2d\u539f\u5b50\u7684\u6570\u91cf\u8fd8\u8981\u591a\u3002\u5f88\u96be\u60f3\u8c61\uff0c\u66f4\u4e0d\u7528\u8bf4\u53bb\u8ba1\u7b97\u771f\u5b9e\u86cb\u767d\u8d28\u9002\u5e94\u5ea6\u666f\u89c2\u7684\u590d\u6742\u62d3\u6251\u7ed3\u6784\u53ca\u5176\u53ef\u80fd\u8def\u5f84\u7684\u6570\u91cf\u3002\u56e0\u6b64\uff0c\u51e0\u5341\u5e74\u6765\uff0c\u9002\u5e94\u5ea6\u666f\u89c2\u53ea\u662f\u6982\u5ff5\u4e0a\u7684\u8f85\u52a9\uff0c\u800c\u975e\u5177\u4f53\u6d4b\u91cf\u7684\u5de5\u5177\u3002\u76f4\u5230\u6700\u8fd1\uff0c\u501f\u52a9\u5148\u8fdb\u7684\u8ba1\u7b97\u80fd\u529b\u548c\u6539\u8fdb\u7684\u5206\u5b50\u751f\u7269\u5b66\u6280\u672f\uff0c\u7814\u7a76\u4eba\u5458\u624d\u80fd\u591f\u5f00\u59cb\u4e3a\u5355\u4e2a\u86cb\u767d\u8d28\u548c\u7ec6\u83cc\u3001\u75c5\u6bd2\u7b49\u7b80\u5355\u751f\u7269\u4f53\u7ed8\u5236\u5b9a\u91cf\u666f\u89c2\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7ec6\u83cc\u548c\u75c5\u6bd2\u51e0\u4e4e\u662f\u7ed8\u5236\u9002\u5e94\u5ea6\u666f\u89c2\u7684\u7406\u60f3\u5bf9\u8c61\u3002\u5728\u8bd5\u7ba1\u4e2d\u751f\u957f\u81f3\u6570\u767e\u4e07\u6216\u6570\u5341\u4ebf\u7684\u6570\u91cf\uff0c\u6bcf\u4e2a\u7ec6\u83cc\u7ec6\u80de\u6216\u75c5\u6bd2\u9897\u7c92\u90fd\u53ef\u4ee5\u4ece\u63cf\u9002\u5e94\u5ea6\u666f\u89c2\u7684\u5de8\u5927\u53d8\u4f53\u5e93\u4e2d\u643a\u5e26\u4e00\u4e2a\u7a81\u53d8\u3002\u5b83\u4eec\u6781\u77ed<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u51e0\u5c0f\u65f6\u6216\u51e0\u5929\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7684\u4ee3\u9645\u5dee\uff0c\u4e5f\u4f7f\u7814\u7a76\u4eba\u5458\u80fd\u591f\u66f4\u5feb\u5730\u8bc6\u522b\u65b0\u7684\u7a81\u53d8\u3002\u5927\u591a\u6570\u4f7f\u7528 RNA \u4f5c\u4e3a\u5176\u9057\u4f20\u7269\u8d28\u7684\u75c5\u6bd2\uff0c\u5305\u62ec HIV \u548c\u4e19\u578b\u809d\u708e\u75c5\u6bd2<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08HCV\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\uff0c\u4e5f\u5f88\u5bb9\u6613\u53d1\u751f\u7a81\u53d8\uff0c\u56e0\u4e3a\u590d\u5236\u5176\u57fa\u56e0\u7ec4\u7684 RNA \u805a\u5408\u9176\u4e0d\u4f1a\u50cf DNA \u805a\u5408\u9176\u90a3\u6837\u6709\u6548\u5730\u6821\u5bf9\u62f7\u8d1d\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7814\u7a76\u4eba\u5458\u9996\u5148\u53d1\u73b0\uff0c\u5c3d\u7ba1\u9002\u5e94\u5ea6\u666f\u89c2\u5f88\u590d\u6742\uff0c\u4f46<strong>\u751f\u7269\u4f53\u901a\u5e38\u4ec5\u5904\u4e8e\u5c11\u6570\u9002\u5e94\u5ea6\u5cf0\u503c\uff0c\u5e76\u4e14\u5176\u95f4\u7684\u8def\u5f84\u6570\u4e5f\u53d7\u9650<\/strong>\u30022006 \u5e74\u53d1\u8868\u4e8e <em>Science<\/em> \u7684\u4e00\u7bc7\u8bba\u6587\u4ed4\u7ec6\u7814\u7a76\u4e86\u4e00\u79cd\u53eb\u505a \u03b2-\u5185\u9170\u80fa\u9176\u7684\u86cb\u767d\u8d28\uff0c\u5b83\u53ef\u4ee5\u4f7f\u9752\u9709\u7d20\u7b49\u6297\u751f\u7d20\u5931\u6d3b [4]\u3002\u03b2-\u5185\u9170\u80fa\u9176\u4e2d\u4e94\u4e2a\u5355\u6838\u82f7\u9178\u7a81\u53d8\u7684\u8054\u5408\u4f5c\u7528\u53ef\u4ee5\u4f7f\u5176\u6297\u751f\u7d20\u8010\u836f\u6027\u589e\u52a0 100000 \u500d\u3002\u65f6\u4efb\u54c8\u4f5b\u5927\u5b66\u6f14\u5316\u751f\u7269\u5b66\u535a\u58eb\u540e\u3001\u73b0\u4efb\u5e03\u6717\u5927\u5b66\u5b9e\u9a8c\u5ba4\u8d1f\u8d23\u4eba\u7684 Daniel Weinreich \u4e0e\u4ed6\u7684\u540c\u4e8b\u6307\u51fa\uff0c\u8be5\u57fa\u56e0\u7684\u6f14\u5316\u53ef\u80fd\u4ee5 120 \u6761\u8def\u5f84\u6765\u7d2f\u79ef\u6240\u6709\u4e94\u79cd\u53d8\u4f53\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><img loading=\"lazy\" class=\"rich_pages wxw-img\" data-backh=\"661\" data-backw=\"562\" data-ratio=\"1.1756876663708962\"  data-type=\"png\" data-w=\"1127\" height=\"auto\" style=\"width: 100%;height: auto;\" width=\"1127\" src=\"\/wp-content\/uploads\/2022\/01\/wxsync-2022-01-633c2dfbda79bcb47212bec504ee3f91.png\"  \/><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.5em;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">\u56fe3. \u03b2-\u5185\u9170\u80fa\u9176\u53ef\u80fd\u4ee5120\u6761\u8def\u5f84\u6765\u79ef\u7d2f\u53d8\u4f53\u3002| \u6765\u6e90\uff1aSamuel Velasco\/Quanta Magazine; doi.org\/10.1126\/science.1123539<\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7136\u800c\uff0c\u5f53\u7814\u7a76\u4eba\u5458\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u521b\u5efa\u548c\u6d4b\u8bd5\u4e2d\u95f4\u53d8\u4f53\u65f6\uff0c\u4ed6\u4eec\u53d1\u73b0\u6709 102 \u6761\u8def\u5f84\u5728\u81ea\u7136\u9009\u62e9\u4e0b\u662f\u4e0d\u53ef\u80fd\u5b58\u5728\u7684\uff0c\u56e0\u4e3a\u5b83\u4eec\u4ea7\u751f\u4e86\u6709\u7f3a\u9677\u6216\u4e0d\u5b8c\u6574\u7684\u86cb\u767d\u8d28\u3002\u968f\u540e\u4ed6\u4eec\u53d1\u73b0\u8bb8\u591a\u5269\u4f59\u7684\u7ec4\u5408\u672a\u80fd\u6539\u5584\u6297\u751f\u7d20\u8010\u836f\u6027\uff0c\u53ef\u80fd\u7684\u6f14\u5316\u8def\u5f84\u8fdb\u4e00\u6b65\u51cf\u5c11\u3002\u5bf9\u6b64\uff0c\u4ed6\u4eec\u8868\u793a\uff0c\u201c<strong>\u751f\u547d\u7684\u86cb\u767d\u8d28\u6f14\u5316\u9014\u5f84\u53ef\u80fd\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u53ef\u590d\u5236\u7684\uff0c\u751a\u81f3\u662f\u53ef\u9884\u6d4b\u7684\u3002<\/strong>\u201d<\/span><\/section>\n<h1 data-foldable-wrapper=\"\">\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<\/h1>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<h3 style=\"outline: 0px;white-space: normal;letter-spacing: 0.544px;font-family: -apple-system, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;font-family: PingFangSC-light;text-align: right;font-size: 13px;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;letter-spacing: 0.544px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;\">\n<section style=\"outline: 0px;display: inline-block;vertical-align: middle;\">\n<section style=\"margin-bottom: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;clear: both;line-height: 0;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;border-left: 3px solid rgb(33, 166, 210);border-right: 3px solid rgb(33, 166, 210);border-top-color: rgb(33, 166, 210);border-bottom-color: rgb(33, 166, 210);font-size: 16px;color: rgb(0, 0, 0);line-height: 1.4;\">\n<p style=\"outline: 0px;\"><strong style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\">3. \u6df1\u5ea6\u7a81\u53d8\u626b\u63cf\uff1a\u5b9e\u9a8c\u5ba4\u4e2d\u7684\u81ea\u7136\u9009\u62e9<\/strong><\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<p style=\"margin-right: 8px;margin-left: 8px;outline: 0px;font-size: 16px;white-space: normal;line-height: 1.75em;\"><br  \/><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u4f46\u5373\u4f7f\u662f\u9884\u6d4b\u6700\u5c0f\u7684\u75c5\u6bd2\u6216\u86cb\u767d\u8d28\u7684\u6f14\u5316\u8f68\u8ff9\uff0c\u4e5f\u9700\u8981\u5bf9\u5176\u9002\u5e94\u5ea6\u73af\u5883\u6709\u8be6\u5c3d\u7684\u4e86\u89e3\uff0c\u800c\u8fd9\u5f88\u96be\u8fbe\u6210\u3002\u4ece\u5386\u53f2\u4e0a\u770b\uff0c\u79d1\u5b66\u5bb6\u4ec5\u80fd\u4e00\u6b21\u4ea7\u751f\u4e00\u4e2a\u6838\u82f7\u9178\u6216\u6c28\u57fa\u9178\u7684\u53d8\u4f53\uff0c\u7136\u540e\u7eaf\u5316\u86cb\u767d\u8d28\u53d8\u4f53\u5e76\u8bc4\u4f30\u5176\u529f\u80fd\u3002\u800c\u68c0\u67e5\u591a\u4e2a\u53ef\u80fd\u7684\u53d8\u4f53\u901a\u5e38\u662f\u4e0d\u5b9e\u9645\u7684\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u6df1\u5ea6\u7a81\u53d8\u626b\u63cf<\/span><\/strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u6280\u672f [5] \u7684\u53d1\u5c55\u6539\u53d8\u4e86\u8fd9\u4e00\u5207\u3002\u8fd9\u79cd\u6280\u672f\u5141\u8bb8\u79d1\u5b66\u5bb6\u4e00\u6b21\u6027\u751f\u6210\u6570\u4ee5\u4e07\u8ba1\u7684\u53d8\u4f53\uff0c\u7136\u540e\u8ba9\u6240\u6709\u53d8\u4f53\u76f8\u4e92\u7ade\u4e89\u4ee5\u786e\u5b9a\u5b83\u4eec\u7684\u76f8\u5bf9\u9002\u5e94\u5ea6\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7814\u7a76\u4eba\u5458\u9996\u5148\u521b\u5efa\u4e86\u4e00\u4e2a\u53ef\u4ee5\u514b\u9686\u5230\u57f9\u517b\u7ec6\u80de\u4e2d\u7684\u53d8\u5f02\u57fa\u56e0\u5e93\u3002\u7531\u57fa\u56e0\u7f16\u7801\u7684\u86cb\u767d\u8d28\uff0c\u5176\u6d3b\u6027\u4e0e\u4e00\u4e9b\u751f\u5316\u529f\u80fd\u6709\u5173\u3002\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u5bf9\u751f\u5316\u529f\u80fd\u65bd\u52a0\u9009\u62e9\uff0c\u53ef\u589e\u52a0\u9002\u5e94\u5ea6\u6700\u9ad8\u3001\u6d3b\u6027\u6700\u9ad8\u7684\u86cb\u767d\u8d28\uff0c\u800c\u6d3b\u6027\u4f4e\u7684\u86cb\u767d\u8d28\u5c06\u6d88\u5931\u3002\u901a\u8fc7\u9ad8\u901a\u91cf DNA \u6d4b\u5e8f\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u7edf\u8ba1\u6bcf\u4e2a\u53d8\u4f53\u7684\u6570\u91cf\uff0c\u4ee5\u5b9a\u91cf\u6d4b\u91cf\u5176\u591a\u4ee3\u7684\u8868\u73b0\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u201c\u8fd9\u662f\u4e00\u79cd\u523b\u753b\u53d8\u4f53\u5f71\u54cd\u7684\u6709\u6548\u65b9\u6cd5\uff0c\u201d\u4f26\u6566 Warnecke \u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u5458 Valerie Soo \u8868\u793a\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5bf9\u4e8e\u6613\u7a81\u53d8\u7684 RNA \u75c5\u6bd2\uff0c\u79d1\u5b66\u5bb6\u751a\u81f3\u4e0d\u5fc5\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u4ea7\u751f\u53d8\u4f53\u2014\u2014\u6613\u51fa\u9519\u7684\u57fa\u56e0\u7ec4\u590d\u5236\u6d41\u7a0b\u4f1a\u5f15\u5165\u7a81\u53d8\uff0c\u81ea\u7136\u4ea7\u751f\u53d8\u4f53\u3002\u75c5\u6bd2\u7684\u6570\u4ee5\u767e\u4e07\u8ba1\u7684\u62f7\u8d1d\uff0c\u6bcf\u4e2a\u90fd\u4e0e\u5176\u76f8\u90bb\u75c5\u6bd2\u7565\u6709\u4e0d\u540c\uff0c\u4ece\u800c\u4ea7\u751f\u75c5\u6bd2\u5b66\u5bb6\u6240\u5b9a\u4e49\u7684\u7a81\u53d8\u7fa4<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08mutant swarm\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\uff0c\u8fd9\u662f\u81ea\u7136\u9009\u62e9\u4fc3\u8fdb\u6f14\u5316\u7684\u539f\u6750\u6599\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u201c\u5fae\u751f\u7269\u7e41\u6b96\u901f\u5ea6\u5982\u6b64\u4e4b\u5feb\uff0c\u4ee5\u81f3\u4e8e\u6f14\u5316\u6bcf\u5929\u90fd\u5728\u53d1\u751f\u3002\u7814\u7a76\u4eba\u5458\u5b9e\u9645\u4e0a\u53ef\u4ee5\u5b9e\u65f6\u76d1\u6d4b\u6f14\u5316\uff0c\u201d\u6cd5\u56fd\u8499\u5f7c\u5229\u57c3 MIVEGEC \u5b9e\u9a8c\u5ba4\u7684\u6f14\u5316\u751f\u6001\u5b66\u5bb6 Samuel Alizon \u8868\u793a\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u7a81\u53d8\u7fa4\u4e2d\u7684\u7a81\u53d8\u5f88\u5c11\u80fd\u88ab\u4f20\u64ad\u7ed9\u65b0\u5bbf\u4e3b\uff0c\u7279\u522b\u662f\u5f53\u611f\u67d3\u4ec5\u9700\u5c11\u91cf\u75c5\u6bd2\u65f6\u3002\u5176\u4e2d\u4e00\u4e9b\u4f20\u64ad\u7eaf\u7cb9\u662f\u5076\u7136\uff0c\u5373\u53d8\u4f53\u5728\u6b63\u786e\u7684\u65f6\u95f4\u51fa\u73b0\u5728\u6b63\u786e\u7684\u4f4d\u7f6e\u3002\u4f46\u901a\u8fc7<strong>\u52fe\u7ed8\u9002\u5e94\u5ea6\u666f\u89c2\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u5c1d\u8bd5\u627e\u51fa\u4e3a\u4ec0\u4e48\u67d0\u4e9b\u53d8\u4f53\u7684\u4f20\u64ad\u9891\u7387\u8fdc\u9ad8\u4e8e\u5176\u4ed6\u53d8\u4f53<\/strong>\uff0c\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u7684\u75c5\u6bd2\u5b66\u5bb6 Raul Andino-Pavlovsky \u8868\u793a\u3002\u201c\u75c5\u6bd2\u4e0d\u4ec5\u9700\u8981\u80fd\u591f\u4ea7\u751f\u591a\u6837\u6027\uff0c\u800c\u4e14\u8fd8\u5fc5\u987b\u80fd\u591f\u5bb9\u5fcd\u8fd9\u79cd\u591a\u6837\u6027\uff0c\u80fd\u627f\u53d7\u53d8\u5316\u7684\u75c5\u6bd2\u5f88\u53ef\u80fd\u662f\u4e00\u79cd\u9002\u5e94\u6027\u66f4\u5f3a\u7684\u75c5\u6bd2\u3002\u201d<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><img loading=\"lazy\" class=\"rich_pages wxw-img\" data-backh=\"230\" data-backw=\"562\" data-ratio=\"0.40895218718209564\"  data-type=\"png\" data-w=\"983\" height=\"auto\" style=\"width: 100%;height: auto;\" width=\"983\" src=\"\/wp-content\/uploads\/2022\/01\/wxsync-2022-01-ea277e50da8d3b56a660cbfe6ed0ff6b.png\"  \/><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.5em;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">\u56fe4. Fred Hutchinson \u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458 Tyler Starr\uff08\u5de6\uff09\u548c Jesse Bloom\uff08\u53f3\uff09\u7814\u7a76\u4e86 SARS-CoV-2 \u523a\u7a81\u86cb\u767d\u7684\u4e00\u4e2a\u5173\u952e\u7ed3\u6784\u57df\uff0c\u4ee5\u627e\u51fa\u5176\u5f15\u8d77\u514d\u75ab\u7cfb\u7edf\u6ce8\u610f\u7684\u90e8\u5206\u3002| \u6765\u6e90\uff1aTyler Starr &amp; Jesse Bloom<\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u6839\u636e\u6f14\u5316\u751f\u7269\u5b66\u5bb6 Tyler Starr \u7684\u8bf4\u6cd5\uff0c\u4e0d\u7ba1\u662f\u5728\u6982\u5ff5\u4e0a\u8fd8\u662f\u5b9a\u91cf\u5316\u4e0a\uff0c\u9002\u5e94\u5ea6\u666f\u89c2\u90fd\u662f\u63cf\u8ff0\u6162\u6027\u6216\u6301\u7eed\u611f\u67d3\u4e2d\uff0c\u75c5\u6bd2\u5982\u4f55\u89c4\u907f\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u4e2d\u548c\u4f5c\u7528\u7684\u5b8c\u7f8e\u65b9\u5f0f\u3002\u4ed6\u52a0\u5165 Fred Hutchinson \u764c\u75c7\u7814\u7a76\u4e2d\u5fc3 Jesse Bloom \u5b9e\u9a8c\u5ba4\uff0c\u5c31\u662f\u4e3a\u4e86\u7814\u7a76 HIV \u5982\u4f55\u5728\u611f\u67d3\u8fc7\u7a0b\u4e2d\u4e0e\u60a3\u8005\u4f53\u5185\u7684\u6297\u4f53\u514d\u75ab\u5171\u540c\u6f14\u5316\u3002\u4ed6\u7684\u76ee\u6807\u662f\u4e86\u89e3<strong>\u75c5\u6bd2\u548c\u514d\u75ab\u7cfb\u7edf\u4e4b\u95f4\u7684\u8fd9\u79cd\u6f14\u5316\u519b\u5907\u7ade\u8d5b\u5982\u4f55\u4ea7\u751f\u5177\u6709\u4fdd\u62a4\u6027\u7684\u6297\u4f53<\/strong>\uff0c\u8fd9\u53ef\u4ee5\u5e2e\u52a9\u79d1\u5b66\u5bb6\u5f00\u53d1\u5173\u6ce8\u75c5\u6bd2\u4e2d\u6052\u5b9a\u90e8\u5206\u7684 HIV \u75ab\u82d7\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u4f46 Starr \u521a\u5f00\u59cb\u4ed6\u7684 HIV \u7814\u7a76\u5de5\u4f5c\uff0c\u53e6\u4e00\u79cd\u75c5\u6bd2\u5c31\u62a2\u8d70\u4e86\u4ed6\u4ee5\u53ca\u5168\u4e16\u754c\u7684\u6ce8\u610f\u529b\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<h1 data-foldable-wrapper=\"\">\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/section>\n<\/h1>\n<h3 style=\"outline: 0px;white-space: normal;letter-spacing: 0.544px;font-family: -apple-system, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;font-family: PingFangSC-light;text-align: right;font-size: 13px;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;letter-spacing: 0.544px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;\">\n<section style=\"outline: 0px;display: inline-block;vertical-align: middle;\">\n<section style=\"margin-bottom: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;clear: both;line-height: 0;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;border-left: 3px solid rgb(33, 166, 210);border-right: 3px solid rgb(33, 166, 210);border-top-color: rgb(33, 166, 210);border-bottom-color: rgb(33, 166, 210);font-size: 16px;color: rgb(0, 0, 0);line-height: 1.4;\">\n<p style=\"outline: 0px;\"><strong style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\">4. \u65b0\u51a0\u75c5\u6bd2\uff0c\u6bd4\u9884\u671f\u66f4\u5bb9\u6613\u7a81\u53d8<\/strong><\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<p style=\"margin-right: 8px;margin-left: 8px;outline: 0px;font-size: 16px;white-space: normal;line-height: 1.75em;\"><br  \/><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u968f\u7740 SARS-CoV-2 \u5f00\u59cb\u5728\u5168\u7403\u4f20\u64ad\uff0c Starr \u548c Bloom \u610f\u8bc6\u5230\uff0c\u9002\u5e94\u5ea6\u666f\u89c2\u4e3a\u7814\u7a76\u8fd9\u79cd\u65b0\u578b\u75c5\u539f\u4f53\u63d0\u4f9b\u4e86\u4e00\u79cd\u6709\u7528\u7684\u65b9\u6cd5\u3002<strong>\u9002\u5e94\u5ea6\u666f\u89c2\u80fd\u591f\u786e\u5b9a\u75c5\u6bd2\u86cb\u767d\u8d28\u4e2d\u7684\u5173\u952e\u56e0\u5b50\uff0c\u4ee5\u53ca\u75c5\u6bd2\u53ef\u4ee5\u627f\u53d7\u7684\u53d8\u5316\u3002<\/strong><\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u6700\u521d\uff0c\u5bf9 SARS-CoV-2 \u8fdb\u884c\u6d4b\u5e8f\u7684\u79d1\u5b66\u5bb6\u5e76\u6ca1\u6709\u6ce8\u610f\u5230\u592a\u591a\u7684\u9057\u4f20\u53d8\u5f02\u3002\u5c3d\u7ba1\u51a0\u72b6\u75c5\u6bd2\u4ee5\u8f83\u6613\u51fa\u9519\u7684 RNA \u805a\u5408\u9176\u6765\u590d\u5236\u9057\u4f20\u7269\u8d28\uff0c\u4f46 SARS-CoV-2 \u6709\u53e6\u4e00\u79cd\u86cb\u767d\u8d28\u6821\u5bf9\u62f7\u8d1d\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u5e76\u672a\u9884\u671f SARS-CoV-2 \u4f1a\u50cf\u6d41\u611f\u6216 HIV \u822c\u5b58\u5728\u5927\u91cf\u53d8\u4f53\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Bloom \u548c Starr \u77e5\u9053\uff0c\u5728\u6700\u5f3a\u70c8\u7684\u6f14\u5316\u538b\u529b\u4e0b\uff0c\u523a\u7a81\u86cb\u767d<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08spike protein\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5c06\u6210\u4e3a\u51a0\u72b6\u75c5\u6bd2\u7684\u4e00\u90e8\u5206\u3002\u56e0\u4e3a\u523a\u7a81\u86cb\u767d\u662f\u514d\u75ab\u7cfb\u7edf\u5728\u8bc6\u522b\u4e0a\u6700\u654f\u611f\u7684\u7269\u8d28\uff0c\u4e5f\u662f\u75c5\u6bd2\u7528\u6765\u4fb5\u5165\u4eba\u4f53\u7ec6\u80de\u7684\u7269\u8d28\u3002\u7136\u800c\uff0c\u523a\u7a81\u86cb\u767d\u542b\u67091273\u4e2a\u6c28\u57fa\u9178\uff0c\u5982\u6b64\u5927\u7684\u89c4\u6a21\u4f7f\u5176\u65e0\u6cd5\u901a\u8fc7\u9002\u5e94\u5ea6\u666f\u89c2\u8fdb\u884c\u5feb\u901f\u8bc4\u4f30\u3002\u56e0\u6b64\uff0c Starr \u51b3\u5b9a\u4e13\u6ce8\u4e8e\u523a\u7a81\u86cb\u767d\u7684\u4e00\u4e2a\u90e8\u5206\uff0c\u5373\u4ec5\u5305\u542b\u51e0\u767e\u4e2a\u6c28\u57fa\u9178\u7684\u53d7\u4f53\u7ed3\u5408\u533a<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08receptor binding domain\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u3002\u540e\u8005\u53ea\u6709\u51e0\u767e\u4e2a\u6c28\u57fa\u9178\uff0c\u662f\u4e00\u4e2a\u66f4\u5bb9\u6613\u89e3\u51b3\u7684\u95ee\u9898\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Starr \u4f7f\u7528\u6df1\u5ea6\u7a81\u53d8\u626b\u63cf\u521b\u5efa\u4e86 4000 \u79cd\u4e0d\u540c\u7684\u53d7\u4f53\u7ed3\u5408\u533a\u53d8\u4f53\u3002\u4ed6\u8bc4\u4f30\u4e86\u5b83\u4eec\u4e0e\u4eba\u7c7b ACE2 \u86cb\u767d<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de\u6240\u9009\u62e9\u7684\u5206\u5b50\u201c\u9501\u201d\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7ed3\u5408\u5e76\u88ab\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u7684\u80fd\u529b [6]\u3002\u5982\u679c SARS-CoV-2 \u4e0d\u80fd\u627f\u53d7\u5176\u53d7\u4f53\u7ed3\u5408\u533a\u7684\u53d8\u5f02\uff0cStarr \u5c06\u4f1a\u770b\u5230\u514d\u75ab\u8bc6\u522b\u6216 ACE2 \u7ed3\u5408\u529f\u80fd\u53d7\u5230\u53d8\u4f53\u7684\u4e25\u91cd\u635f\u5bb3\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<p style=\"margin-left: 8px;margin-right: 8px;\"><iframe class=\"video_iframe rich_pages\" data-vidtype=\"2\" data-mpvid=\"wxv_2244382721047314436\" data-cover=\"http%3A%2F%2Fmmbiz.qpic.cn%2Fmmbiz_jpg%2FwibWV1DB7tWJ7sEp8wm0EBKBibaiaYFFFLHX1IT5a9nnyqmAUOoqBcUnzTRPUAs9QFNB8QVUrA5dvG4pMqK9U8b6Q%2F0%3Fwx_fmt%3Djpeg\" allowfullscreen=\"\" frameborder=\"0\" data-ratio=\"0.8894009216589862\" data-w=\"386\"  src=\"https:\/\/mp.weixin.qq.com\/mp\/readtemplate?t=pages\/video_player_tmpl&amp;action=mpvideo&amp;auto=0&amp;vid=wxv_2244382721047314436\" width=\"100%\" height=\"434\"><\/iframe><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.5em;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">SARS-CoV-2 \u523a\u7a81\u86cb\u767d\uff08\u5e95\u90e8\uff09\u4e0e\u7ec6\u80de\u53d7\u4f53\u7ed3\u5408\u7684\u53d7\u4f53\u7ed3\u5408\u533a\u6a21\u578b\uff0c\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528\u4f7f\u75c5\u6bd2\u80fd\u591f\u8fdb\u5165\u7ec6\u80de\u3002\u86cb\u767d\u8d28\u7684\u7ea2\u8272\u533a\u57df\u4e0d\u80fd\u8f7b\u6613\u6f14\u5316\uff0c\u56e0\u4e3a\u5176\u7a81\u53d8\u4f1a\u963b\u6b62\u86cb\u767d\u8d28\u5de5\u4f5c\u3002| \u6765\u6e90\uff1aTyler Starr<\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u4f46\u8fd9\u5e76\u4e0d\u662f\u5b9e\u9645\u53d1\u751f\u7684\u4e8b\u60c5\u3002\u201c\u53d7\u4f53\u7ed3\u5408\u533a\u6709\u8bb8\u591a\u4e0d\u540c\u7684\u53d8\u4f53\uff0c\u5b83\u4eec\u5b9e\u9645\u4e0a\u63d0\u9ad8\u4e86\u4eb2\u548c\u529b\uff0c\u201d Starr\u8868\u793a\u3002\u201c\u8fd9\u770b\u8d77\u6765\u50cf\u662f\u4e00\u4e2a\u975e\u5e38\u5305\u5bb9\u7684\u7ed3\u6784\u57df\uff0c\u5177\u6709\u5f88\u9ad8\u7684\u6f14\u5316\u80fd\u529b\u3002\u7136\u800c\uff0c\u5f53\u65f6\u7684\u60f3\u6cd5\u662f\u51a0\u72b6\u75c5\u6bd2\u4e0d\u4f1a\u4ee5\u6297\u539f\u65b9\u5f0f\u6f14\u5316\u3002\u75c5\u6bd2\u57fa\u56e0\u7ec4\u53ef\u80fd\u5f88\u7a33\u5b9a\u3002\u201d<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u867d\u7136\u53d7\u4f53\u7ed3\u5408\u533a\u80fd\u591f\u627f\u53d7\u6bd4\u9884\u671f\u66f4\u591a\u7684\u53d8\u5f02\uff0c\u4f46\u5e76\u4e0d\u662f\u6240\u6709\u7684\u523a\u7a81\u86cb\u767d\u90fd\u53ef\u4ee5\u3002Starr \u8868\u793a\uff0c\u523a\u7a81\u86cb\u767d\u7684\u8fd9\u4e9b\u90e8\u5206\u56e0\u6b64\u53ef\u80fd\u662f\u65b0\u75ab\u82d7\u548c\u5355\u514b\u9686\u6297\u4f53\u7684\u826f\u597d\u9776\u6807\uff0c\u56e0\u4e3a\u5b83\u4eec\u4e0d\u592a\u53ef\u80fd\u968f\u7740\u65f6\u95f4\u63a8\u79fb\u53d1\u751f\u7a81\u53d8\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Starr \u8868\u793a\uff0c\u5f53\u4ed6\u4eec\u4e8e 2020 \u5e74 6 \u6708\u9996\u6b21\u5728 biorxiv.org \u9884\u5370\u672c\u670d\u52a1\u5668\u4e0a\u53d1\u5e03\u8fd9\u4e9b\u7ed3\u679c\u65f6\uff0c\u6572\u54cd\u4e86\u4e00\u4e2a\u5de8\u5927\u7684\u8b66\u949f\uff0c<strong>\u8fd9\u662f SARS-CoV-2 \u6bd4\u4eba\u4eec\u60f3\u8c61\u7684\u66f4\u6613\u53d8\u5f02\u7684\u6700\u521d\u8ff9\u8c61\u4e4b\u4e00<\/strong>\u3002\u73b0\u5728 Starr \u548c Bloom \u6b63\u5728\u91cd\u590d\u4ed6\u4eec\u5bf9 alpha\u3001beta\u3001gamma\u3001delta \u548c omicron \u53d8\u4f53\u7684\u6df1\u5ea6\u7a81\u53d8\u626b\u63cf\u5b9e\u9a8c\uff0c\u4ee5\u83b7\u5f97\u5173\u4e8e\u5b83\u4eec\u7684\u53d7\u4f53\u7ed3\u5408\u533a\u7684\u7c7b\u4f3c\u89c1\u89e3\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Starr\u3001Bloom \u53ca\u5176\u540c\u4e8b\u8fd8\u521b\u5efa\u4e86\u4e00\u4e2a\u4e0d\u6d89\u53ca ACE2 \u7ed3\u5408\u4f53\u7684\u53d7\u4f53\u7ed3\u5408\u533a\u6240\u6709\u53ef\u80fd\u7a81\u53d8\u7684\u56fe\u8c31\u3002\u4ed6\u4eec\u5728 2021 \u5e74 1 \u6708\u53d1\u8868\u4e8e <em>Science<\/em> \u7684\u5de5\u4f5c [7]\uff0c\u786e\u5b9a\u4e86\u8be5\u7ed3\u6784\u57df\u53ef\u80fd\u89c4\u907f\u5355\u514b\u9686\u6297\u4f53\u7597\u6cd5\u4e2d\u548c\u4f5c\u7528\u7684\u53ef\u80fd\u7a81\u53d8\u3002\u4ed6\u4eec\u7684\u5de5\u4f5c\u8fd8\u8bc6\u522b\u4e86\u5728\u611f\u67d3 SARS-CoV-2 \u540e 150 \u5929\u7684\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u7684\u4e2a\u4f53\u4e2d\u51fa\u73b0\u7684\u51e0\u79cd\u7a81\u53d8\u3002\u5f53\u75c5\u4eba\u5728\u7b2c 145 \u5929\u63a5\u53d7\u5355\u514b\u9686\u6297\u4f53\u6cbb\u7597\u65f6\uff0c\u75c5\u6bd2\u5df2\u7ecf\u5bf9\u5e02\u9762\u4e0a\u53ef\u7528\u7684\u836f\u54c1\u4ea7\u751f\u4e86\u8010\u836f\u6027\u3002\u5bf9 Starr \u6765\u8bf4\uff0c\u8fd9\u8868\u660e\u8fd9\u4e9b\u5177\u6709\u6cbb\u7597\u6548\u679c\u7684\u5355\u514b\u9686\u6297\u4f53\u53ef\u80fd\u4f1a\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u53d8\u5f97\u4e0d\u90a3\u4e48\u6709\u6548\uff0c\u65e0\u8bba\u662f\u5728\u5355\u4e2a\u60a3\u8005\u4f53\u5185\uff0c\u8fd8\u662f\u9762\u5bf9\u66f4\u666e\u904d\u7684\u75c5\u6bd2\u7a81\u53d8\u65f6\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u6b64\u5916\uff0c\u6b63\u5982 Starr\u3001Bloom \u548c\u4ed6\u4eec\u7684\u540c\u4e8b\u53bb\u5e74\u590f\u5929\u5728 <em>Nature Communications<\/em> [8] \u4e0a\u6240\u63cf\u8ff0\u7684\u90a3\u6837\uff0c\u51e0\u79cd\u666e\u904d\u7684\u7a81\u53d8\u90fd\u53ef\u4ee5\u5e2e\u52a9 SARS-CoV-2 \u89c4\u907f\u514d\u75ab\u7cfb\u7edf\u9488\u5bf9\u53d7\u4f53\u7ed3\u5408\u533a\u4e2d\u6700\u5177\u9488\u5bf9\u6027\u7684\u90e8\u5206\u7684\u4e00\u4e9b\u6297\u4f53\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8fd8\u6ca1\u6709\u75c5\u6bd2\u8c31\u7cfb\u6f14\u5316\u4e3a\u5177\u6709\u6240\u6709\u8fd9\u4e09\u79cd\u7a81\u53d8\u3002\u201c\u7136\u800c\uff0c\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u8fd9\u79cd\u53d8\u4f53\u7684\u51fa\u73b0\u5c06\u662f\u4e00\u4e2a\u4ee4\u4eba\u62c5\u5fe7\u7684\u53d1\u5c55\uff0c\u5e94\u8be5\u5bc6\u5207\u5173\u6ce8\u3002\u201d\u4ed6\u4eec\u5199\u9053\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">2019 \u5e74\u5e95\u9996\u6b21\u51fa\u73b0 SARS-CoV-2 \u7684\u4e16\u754c\u4e0e\u5f53\u4eca\u4e16\u754c\u4e0d\u540c\u3002\u75c5\u6bd2\u4ea7\u751f\u5927\u91cf\u62f7\u8d1d\u5e76\u5728\u4e2a\u4f53\u95f4\u4f20\u64ad\u7684\u80fd\u529b\u65e0\u7591\u662f\u5176\u5728\u75ab\u60c5\u521d\u671f\u53d6\u5f97\u6210\u529f\u7684\u5173\u952e\u3002\u7136\u800c\uff0c\u968f\u7740\u901a\u8fc7\u75ab\u82d7\u63a5\u79cd\u548c\u81ea\u7136\u83b7\u5f97\u6027\u611f\u67d3\u514d\u75ab\u7684\u4eba\u6570\u589e\u52a0\uff0c\u75c5\u6bd2\u5c06\u627f\u53d7\u66f4\u5927\u7684\u538b\u529b\u6765\u89c4\u907f\u514d\u75ab\u53cd\u5e94\u3002Lauring \u8868\u793a\uff0c\u8bb8\u591a\u7a81\u53d8\u90fd\u9700\u8981\u6743\u8861\u5229\u5f0a\uff0cSARS-CoV-2 \u4e5f\u4e0d\u4f8b\u5916\u3002\u80fd\u591f\u5e2e\u52a9\u75c5\u6bd2\u89c4\u907f\u514d\u75ab\uff0c\u4f46\u5374\u51cf\u5c11\u5176\u4f20\u64ad\u7684\u7a81\u53d8\u53ef\u80fd\u5728 2020 \u5e74\u521d\u4e0d\u53d7\u9752\u7750\uff0c\u4f46\u73b0\u5728\u5219\u4e0d\u540c\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Lauring\u8868\u793a\uff1a\u201c\u6211\u4eec\u4eba\u7c7b\u662f\u75c5\u6bd2\u751f\u5b58\u7684\u73af\u5883\uff0c\u5982\u679c\u6211\u4eec\u6539\u53d8\uff0c\u9002\u5e94\u5ea6\u666f\u89c2\u5c31\u4f1a\u6539\u53d8\u3002\u201d<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 2em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 2em;\"><strong><span style=\"font-size: 15px;color: rgb(33, 166, 210);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/strong><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: normal;margin-bottom: 10px;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">[1] Huang, Y., Yang, C., Xu, Xf.&nbsp;et al.&nbsp;Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19.&nbsp;Acta Pharmacol Sin&nbsp;41,&nbsp;1141\u20131149 (2020).&nbsp;<\/span><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">https:\/\/doi.org\/10.1038\/s41401-020-0485-4<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: normal;margin-bottom: 10px;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">[2]&nbsp;<\/span><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">https:\/\/www.science.org\/doi\/10.1126\/science.abf9302<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: normal;margin-bottom: 10px;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">[3] Greaney, A.J., Starr, T.N., Barnes, C.O.&nbsp;et al.&nbsp;Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies.&nbsp;Nat Commun&nbsp;12,&nbsp;4196 (2021).&nbsp;<\/span><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">https:\/\/doi.org\/10.1038\/s41467-021-24435-8<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: normal;margin-bottom: 10px;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">[4]&nbsp;<\/span><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">https:\/\/www.science.org\/doi\/10.1126\/science.1123539<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: normal;margin-bottom: 10px;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">[5] Carlos L. Araya, Douglas M. Fowler. Deep mutational scanning: assessing protein function on a massive scale. Trends in Biotechnology, Volume 29, Issue 9,<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: normal;margin-bottom: 10px;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">2011, Pages 435-442, ISSN 0167-7799.&nbsp;<\/span><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">https:\/\/doi.org\/10.1016\/j.tibtech.2011.04.003.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: normal;margin-bottom: 10px;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">[6] Tyler N. Starr, et al. Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding. Cell, VOLUME 182, ISSUE 5,&nbsp;P1295-1310.E20,&nbsp;SEPTEMBER 03, 2020. DOI:<\/span><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">https:\/\/doi.org\/10.1016\/j.cell.2020.08.012<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: normal;margin-bottom: 10px;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">[7]&nbsp;<\/span><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">https:\/\/www.science.org\/doi\/10.1126\/science.abf9302<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: normal;margin-bottom: 10px;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">[8] Greaney, A.J., Starr, T.N., Barnes, C.O.&nbsp;et al.&nbsp;Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies.&nbsp;Nat Commun&nbsp;12,&nbsp;4196 (2021).&nbsp;<\/span><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">https:\/\/doi.org\/10.1038\/s41467-021-24435-8<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: normal;margin-bottom: 10px;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: normal;margin-bottom: 10px;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">\u539f\u6587\u94fe\u63a5\uff1a<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: normal;margin-bottom: 10px;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\"><\/span><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">https:\/\/www.quantamagazine.org\/evolution-landscapes-predict-whats-next-for-covid-virus-20220111\/<\/span><\/section>\n<p><br style=\"white-space: normal;\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"display: none;line-height: 0px;\">\u200d<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/p>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);text-align: center;justify-content: center;\">\n<section style=\"outline: 0px;display: inline-block;width: auto;vertical-align: top;min-width: 10%;height: auto;box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-bottom: 9px solid rgb(169, 215, 227);border-bottom-right-radius: 0px;\">\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: -15px;outline: 0px;\">\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;color: rgb(12, 130, 169);font-size: 16px;line-height: 2;letter-spacing: 3px;\">\n<p style=\"outline: 0px;\"><strong style=\"outline: 0px;\">\u590d\u6742\u79d1\u5b66\u6700\u65b0\u8bba\u6587<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);\">\n<p style=\"outline: 0px;\"><br style=\"outline: 0px;color: rgb(63, 63, 63);font-family: PingFangSC-light;font-size: 15px;letter-spacing: 0.544px;\"  \/><\/p>\n<\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);line-height: 1.75em;\"><span style=\"outline: 0px;font-size: 15px;\">\u96c6\u667a\u6591\u56fe\u9876\u520a\u8bba\u6587\u901f\u9012\u680f\u76ee\u4e0a\u7ebf\u4ee5\u6765\uff0c\u6301\u7eed\u6536\u5f55\u6765\u81ea<span style=\"outline: 0px;font-style: italic;\">Nature\u3001Science<\/span>\u7b49\u9876\u520a\u7684\u6700\u65b0\u8bba\u6587\uff0c\u8ffd\u8e2a\u590d\u6742\u7cfb\u7edf\u3001\u7f51\u7edc\u79d1\u5b66\u3001\u8ba1\u7b97\u793e\u4f1a\u79d1\u5b66\u7b49\u9886\u57df\u7684\u524d\u6cbf\u8fdb\u5c55\u3002\u73b0\u5728\u6b63\u5f0f\u63a8\u51fa\u8ba2\u9605\u529f\u80fd\uff0c\u6bcf\u5468\u901a\u8fc7\u5fae\u4fe1\u670d\u52a1\u53f7\u300c\u96c6\u667a\u6591\u56fe\u300d\u63a8\u9001\u8bba\u6587\u4fe1\u606f\u3002\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\u5373\u53ef\u4e00\u952e\u8ba2\u9605\uff1a<\/span><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;outline: 0px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;background-color: rgb(255, 255, 255);text-align: center;\"><img class=\"rich_pages wxw-img\" data-ratio=\"0.3088962108731466\" data-s=\"300,640\"  data-type=\"png\" data-w=\"1214\" style=\"outline: 0px;box-sizing: border-box !important;visibility: visible !important;width: 677px !important;height: auto !important;\" src=\"\/wp-content\/uploads\/2022\/01\/wxsync-2022-01-fdadfa689e4fd2c0d00404fdcd994125.png\"  \/><\/p>\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);\">\n<p style=\"margin-right: 8px;margin-bottom: 5px;margin-left: 8px;outline: 0px;\"><br style=\"outline: 0px;letter-spacing: 0.544px;\"  \/><\/p>\n<\/section>\n<p style=\"margin-right: 8px;margin-bottom: 5px;margin-left: 8px;outline: 0px;font-family: -apple-system, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;background-color: rgb(255, 255, 255);\"><br  \/><\/p>\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;background-color: rgb(255, 255, 255);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\">\n<p style=\"margin-right: 8px;margin-bottom: 5px;margin-left: 8px;outline: 0px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;color: rgb(0, 0, 0);font-size: 16px;text-align: center;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\"><span style=\"outline: 0px;font-size: 15px;letter-spacing: 0.544px;\">\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n<ul class=\"list-paddingleft-2\" style=\"outline: 0px;\">\n<li style=\"outline: 0px;font-weight: bold;\">\n<section style=\"margin-right: 8px;margin-bottom: 10px;margin-left: 8px;outline: 0px;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247589522&amp;idx=1&amp;sn=c2e5d96adf82dab8dae39119811bfc1a&amp;chksm=e896c41fdfe14d09c0ea482d5382a88a27f0f920c666ac9211606630186e7879e307bb2fc5fe&amp;scene=21#wechat_redirect\" textvalue=\"\u4f20\u67d3\u75c5\u76d1\u6d4b\u7684\u6570\u636e\u79d1\u5b66\u65b9\u6cd5\u7279\u520a\uff1a\u5927\u6570\u636e\u600e\u6837\u5e94\u5bf9\u5927\u6d41\u884c\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" style=\"text-decoration: underline;\" data-linktype=\"2\" rel=\"noopener noreferrer\">\u4f20\u67d3\u75c5\u76d1\u6d4b\u7684\u6570\u636e\u79d1\u5b66\u65b9\u6cd5\u7279\u520a\uff1a\u5927\u6570\u636e\u600e\u6837\u5e94\u5bf9\u5927\u6d41\u884c<\/a><\/section>\n<\/li>\n<li style=\"outline: 0px;font-weight: bold;\">\n<section style=\"margin-right: 8px;margin-bottom: 10px;margin-left: 8px;outline: 0px;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247595120&amp;idx=4&amp;sn=3fa3b226272b45f5485bf774a384d746&amp;chksm=e8962efddfe1a7eb54c27b308f421a23e7b8789730cb87792032e24f3dd972079fa9bb0e80d9&amp;scene=21#wechat_redirect\" textvalue=\"\u7814\u7a76\u901f\u9012\uff1a\u6df1\u5ea6\u5b66\u4e60\u5f15\u5165\u9002\u5e94\u6027\uff0c\u63d0\u5347\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u80fd\u529b\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" style=\"text-decoration: underline;\" data-linktype=\"2\" rel=\"noopener noreferrer\">\u7814\u7a76\u901f\u9012\uff1a\u6df1\u5ea6\u5b66\u4e60\u5f15\u5165\u9002\u5e94\u6027\uff0c\u63d0\u5347\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u80fd\u529b<\/a><\/section>\n<\/li>\n<li style=\"outline: 0px;font-weight: bold;\">\n<section style=\"margin-right: 8px;margin-bottom: 10px;margin-left: 8px;outline: 0px;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247585018&amp;idx=1&amp;sn=8f03670bd2156162829220419ffe1c30&amp;chksm=e896d677dfe15f61eae99f869b07dee9a996b1656f1dd8a2ba709e0546026849e5dfa8239b66&amp;scene=21#wechat_redirect\" textvalue=\"\u8001\u836f\u65b0\u7528\u6cbb\u7597\u65b0\u51a0\u75be\u75c5\uff1f\u7f51\u7edc\u533b\u5b66\u6846\u67b6\u52a0\u901f\u836f\u7269\u7814\u53d1\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" style=\"text-decoration: underline;\" data-linktype=\"2\" rel=\"noopener noreferrer\">\u8001\u836f\u65b0\u7528\u6cbb\u7597\u65b0\u51a0\u75be\u75c5\uff1f\u7f51\u7edc\u533b\u5b66\u6846\u67b6\u52a0\u901f\u836f\u7269\u7814\u53d1<\/a><br  \/><\/section>\n<\/li>\n<li style=\"outline: 0px;font-weight: bold;\">\n<section style=\"margin-right: 8px;margin-bottom: 10px;margin-left: 8px;outline: 0px;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247576923&amp;idx=2&amp;sn=57f0d320812c01ff6f5ea97c09fc9623&amp;chksm=e896f7d6dfe17ec038e8d238dae313119fca8c62aabd4730896bc99398db981dd5d9d3e0b927&amp;scene=21#wechat_redirect\" textvalue=\"\u300a\u5f20\u6c5f\u00b7\u590d\u6742\u79d1\u5b66\u524d\u6cbf27\u8bb2\u300b\u5b8c\u6574\u4e0a\u7ebf\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" style=\"text-decoration: underline;\" data-linktype=\"2\" rel=\"noopener noreferrer\">\u300a\u5f20\u6c5f\u00b7\u590d\u6742\u79d1\u5b66\u524d\u6cbf27\u8bb2\u300b\u5b8c\u6574\u4e0a\u7ebf\uff01<\/a><\/section>\n<\/li>\n<li style=\"outline: 0px;font-weight: bold;\">\n<section style=\"margin-right: 8px;margin-bottom: 10px;margin-left: 8px;outline: 0px;\"><span style=\"outline: 0px;letter-spacing: 0.544px;text-decoration: underline;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247555842&amp;idx=1&amp;sn=383e07df94e429aa66628a22471b37dc&amp;chksm=e897418fdfe0c899169c672f35d92217a17a558ea929f85aef402b1ec074ed2e1176472a3cc7&amp;scene=21#wechat_redirect\" textvalue=\"\u96c6\u667a\u5b66\u56ed\u5e74\u8d39VIP\u8ba1\u5212\u5f00\u542f\uff0c\u4e00\u8d77\u63a2\u7d22\u590d\u6742\u6027\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" wah-hotarea=\"click\" hasload=\"1\" style=\"outline: 0px;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);cursor: pointer;\" rel=\"noopener noreferrer\">\u6210\u4e3a\u96c6\u667aVIP\uff0c\u89e3\u9501\u5168\u7ad9\u8bfe\u7a0b\uff0f\u8bfb\u4e66\u4f1a<\/a><\/span><\/section>\n<\/li>\n<li style=\"outline: 0px;\">\n<section style=\"margin-right: 8px;margin-bottom: 10px;margin-left: 8px;outline: 0px;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247571346&amp;idx=2&amp;sn=bbaa3da959582bf7575e7c32089e155e&amp;chksm=e8968d1fdfe1040999b2716ea642129064c032a3b84227f51cdc055b82be97682be43d490dd8&amp;scene=21#wechat_redirect\" textvalue=\"\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" wah-hotarea=\"click\" hasload=\"1\" style=\"outline: 0px;text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);cursor: pointer;\" rel=\"noopener noreferrer\"><strong style=\"outline: 0px;\">\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/a><br style=\"outline: 0px;\"  \/><\/section>\n<\/li>\n<\/ul>\n<p style=\"margin-right: 8px;margin-bottom: 5px;margin-left: 8px;outline: 0px;\"><br style=\"outline: 0px;\"  \/><\/p>\n<\/section>\n<p style=\"outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;background-color: rgb(255, 255, 255);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"outline: currentcolor none 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;background-color: rgb(255, 255, 255);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;font-size: 15px;text-align: left;color: rgb(255, 255, 255);font-family: PingFangSC-light;\"><span style=\"outline: 0px;background-color: rgb(12, 130, 169);\">\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c<strong style=\"outline: 0px;letter-spacing: 0.544px;white-space: normal;font-size: 15px;text-align: left;color: rgb(255, 255, 255);font-family: PingFangSC-light;\">\u8ffd\u8e2a\u590d\u6742\u79d1\u5b66\u9876\u520a\u8bba\u6587<\/strong><\/span><\/strong><\/p>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5bfc\u8bed \u65b0\u51a0\u75ab\u60c5\u597d\u4f3c\u4e00\u573a\u4e16\u754c\u5927\u6218\uff0c\u75c5\u6bd2\u6f14\u5316\u4e0e\u4eba\u7c7b\u6297\u75ab\u624b\u6bb5\u7684\u53d1\u5c55\u5728\u4e0a\u6f14\u4e00\u51fa\u7279\u522b\u7684\u519b\u5907\u7ade\u8d5b\u3002Alpha\u3001Beta\u3001Delta\u4ee5\u53ca\u6700\u65b0\u7684Omicron\u53d8\u5f02\u6bd2\u682a\u4e0d\u65ad\u51b2\u51fb\u7740\u4eba\u7c7b\u7684\u6297\u75ab\u6218\u7ebf\u3002\u9762\u5bf9\u5982\u6b64\u6218\u51b5\uff0c\u6211\u4eec\u5982\u4f55\u628a\u63e1\u4e3b\u52a8\uff1f\u662f\u5426\u6709\u53ef\u80fd\u9884\u6d4b\u65b0\u51a0\u75c5\u6bd2\u7684\u6f14\u5316\uff1fFred Hutchinson 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