{"id":33916,"date":"2022-04-18T22:55:00","date_gmt":"2022-04-18T14:55:00","guid":{"rendered":"https:\/\/swarma.org\/?p=33916"},"modified":"2022-04-18T22:55:00","modified_gmt":"2022-04-18T14:55:00","slug":"cell-%e5%ad%90%e5%88%8a%e5%90%8c%e6%9c%9f%e4%b8%8a%e7%ba%bf%e4%b8%a4%e7%af%87%e6%9d%a5%e8%87%aa%e6%b5%99%e6%b1%9f%e5%a4%a7%e5%ad%a6%e7%9a%84%e7%a0%94%e7%a9%b6%ef%bc%8c%e8%a7%a3%e7%a0%81%e5%ad%a6","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=33916","title":{"rendered":"Cell \u5b50\u520a\u540c\u671f\u4e0a\u7ebf\u4e24\u7bc7\u6765\u81ea\u6d59\u6c5f\u5927\u5b66\u7684\u7814\u7a76\uff0c\u89e3\u7801\u5b66\u4e60\u8bb0\u5fc6\u7684\u65b0\u673a\u5236"},"content":{"rendered":"
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\u5317\u4eac\u65f6\u95f42022\u5e744\u670812\u65e523\u65f6\u6574\uff0cCell Reports<\/em>\u5728\u7ebf\u520a\u767b\u4e86\u6d59\u6c5f\u5927\u5b66\u8111\u79d1\u5b66\u4e0e\u8111\u533b\u5b66\u5b66\u9662\u9a6c\u6b22\u6559\u6388\u56e2\u961f\u4e0e\u9999\u6e2f\u6d78\u4f1a\u5927\u5b66\u7269\u7406\u7cfb\u5468\u660c\u677e\u6559\u6388\u56e2\u961f\u5173\u4e8e\u5927\u8111\u795e\u7ecf\u7f51\u7edc\u5728\u7279\u5b9a\u9891\u6bb5\u53ef\u5851\u6027\u6ce2\u52a8\u7684\u751f\u7406\u610f\u4e49\u7684\u7814\u7a76\uff0c\u9898\u4e3a\u201cRational designing of oscillatory rhythmicity for memory rescue in plasticity-impaired learning networks\u201d\u3002 <\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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a\uff0c\u5206\u5b50\u7ec6\u80de\u751f\u7269\u5b66\u6280\u672f; b\uff0c\u819c\u7247\u94b3\u6280\u672f\uff1bc\uff0c\u5149\u9057\u4f20\u5b66\uff1bd\uff0c\u5728\u4f53\u9499\u6210\u50cf\uff1be\uff0c\u5728\u4f53\u591a\u901a\u9053\uff1bf\uff0c\u7761\u7720\uff1bg\uff0c\u751f\u7269\u4fe1\u606f\u5b66\u3002<\/span><\/p>\n


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\u8054\u7cfb\u65b9\u5f0f\uff1a<\/span><\/strong>mah@zju.edu.cn;<\/span><\/p>\n

\u8bfe\u9898\u7ec4\u7f51\u5740\uff1a<\/span><\/strong>https:\/\/person.zju.edu.cn\/mah<\/span><\/p>\n


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\u5177\u4f53\u6765\u8bf4\uff0c\u7814\u7a76\u4eba\u5458\u51c6\u5907\u4e86\u4e24\u7ec4\u89c6\u89c9\u523a\u6fc0\uff0c\u5176\u4e2d\u4e00\u7ec4\u7531\u4e09\u79cd\u4e0d\u540c\u7684\u65e0\u8272\u5085\u91cc\u53f6\u53d8\u6362\u5b50\u56fe\u5f62\u7ec4\u6210\u7ebf\u7d22\u523a\u6fc0\uff0c\u53e6\u4e00\u7ec4\u7531\u7528\u4e09\u79cd\u989c\u8272\u4e4b\u4e00\u7740\u8272\u7684\u5f62\u72b6\u7ec4\u6210\u9009\u9879\u523a\u6fc0\uff0c\u7136\u540e\u5c06\u4e24\u7ec4\u523a\u6fc0\u4eba\u4e3a\u5730\u4e00\u4e00\u5173\u8054\u7ec4\u5408\u3002<\/span><\/p>\n


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\u5f53\u7315\u7334\u62c9\u52a8\u64cd\u7eb5\u6746\u65f6\uff0c\u7315\u7334\u524d\u9762\u7684\u663e\u793a\u5668\u5c06\u5448\u73b0\u5176\u4e2d\u4e00\u4e2a\u65e0\u8272\u523a\u6fc0\uff0c\u7ecf\u8fc72\u79d2\u7684\u5ef6\u65f6\u671f\u540e\uff0c\u5176\u4e2d\u4e00\u4e2a\u6709\u989c\u8272\u7684\u5f62\u72b6\u523a\u6fc0\u5c06\u4f1a\u51fa\u73b0\u5728\u663e\u793a\u5668\u4e0a\u3002\u5982\u679c\u5f62\u72b6\u523a\u6fc0\u7684\u989c\u8272\u4e0e\u6700\u5f00\u59cb\u5448\u73b0\u7684\u65e0\u8272\u523a\u6fc0\u76f8\u5173\u8054<\/span>\uff08\u5982\u56fe\u4e2d\u7684\u7eff\u8272\uff09<\/span>\uff0c\u5219\u7315\u7334\u677e\u5f00\u64cd\u7eb5\u6746\u5e76\u83b7\u5f97\u679c\u6c41\u5956\u52b1\u3002\u8fd9\u610f\u5473\u7740\u8fd9\u53ea\u7315\u7334\u5e94\u8be5\u5728\u5ef6\u8fdf\u671f\u95f4\u56de\u5fc6\u8d77\u4e86\u5b83\u5e94\u8be5\u54cd\u5e94\u7684\u989c\u8272\u3002<\/span><\/p>\n


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\u5728\u53e6\u4e00\u4e2a\u989c\u8272\u88ab\u52a8\u6ce8\u89c6\u4efb\u52a1\u4e2d\uff0c\u7315\u7334\u88ab\u5448\u73b0\u4e00\u4e2a\u6709\u989c\u8272\u7684\u5f62\u72b6\u523a\u6fc0\uff0c\u5e76\u5728\u5ef6\u8fdf\u4e00\u6bb5\u65f6\u95f4\u540e\u677e\u5f00\u64cd\u7eb5\u6746\u65f6\u83b7\u5f97\u5956\u52b1\u3002<\/span><\/p>\n


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\u56fe2 \u989c\u8272\u56de\u5fc6\u4efb\u52a1<\/span><\/section>\n


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\u901a\u8fc7\u690d\u5165\u768464\u901a\u9053\u7535\u6781<\/span>\uff088\u27158\uff0c\u7535\u6781\u4e2d\u5fc3\u8ddd\u4e3a2.5mm\uff09<\/span>\u9635\u5217<\/span>\uff08\u89c1\u56fe3\u53f3\uff09<\/span>\uff0c\u7814\u7a76\u7ec4\u8bb0\u5f55\u4e86\u7315\u7334\u5728\u6267\u884c\u8fd9\u4e9b\u4efb\u52a1\u671f\u95f4\u524d\u989d\u53f6\u76ae\u5c42\u7684\u76ae\u5c42\u8111\u7535\u4fe1\u53f7\u3002\u4ece\u8bb0\u5f55\u7684\u4fe1\u53f7\u4e2d\u63d0\u53d6\u4e0d\u540c\u9891\u6bb5\u7684\u795e\u7ecf\u632f\u8361\u4fe1\u53f7\uff0c\u5e76\u4f7f\u7528\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u6765\u786e\u5b9a\u795e\u7ecf\u632f\u8361\u7684\u7a7a\u95f4\u6a21\u5f0f\u662f\u5426\u5177\u6709\u89e3\u7801\u56de\u5fc6\u6216\u611f\u77e5\u989c\u8272\u4fe1\u606f\u7684\u80fd\u529b\u3002<\/span><\/p>\n


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\u7ed3\u679c\u8868\u660e\uff0c\u7279\u5b9a\u9891\u6bb5\u548c\u7279\u5b9a\u533a\u57df\u7684\u795e\u7ecf\u632f\u8361\u6a21\u5f0f\u786e\u5b9e\u5305\u542b\u4e86\u8fd9\u4e9b\u989c\u8272\u4fe1\u606f\u3002\u5177\u4f53\u800c\u8a00\uff0c\u03b2\u6ce2<\/span>\uff0813-30Hz\uff09<\/span>\u6a21\u5f0f\u4e0b\u5bf9\u80cc\u4fa7\u524d\u989d\u53f6\u76ae\u5c42\u4e2d\u56de\u5fc6\u7684\u989c\u8272\u663e\u793a\u51fa\u4e86\u8f83\u9ad8\u7684\u89e3\u7801\u6b63\u786e\u7387\uff0c\u800c\u5bf9\u8179\u4fa7\u524d\u989d\u53f6\u76ae\u5c42\u4e2d\u611f\u77e5\u7684\u989c\u8272\u663e\u793a\u51fa\u4e86\u8f83\u9ad8\u7684\u89e3\u7801\u6b63\u786e\u7387<\/span>\uff08\u56fe3\u5de6\u548c\u4e2d\uff09<\/span>\u3002<\/span><\/p>\n


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\u8179\u4fa7\u533a\u57df\u7684\u03b8\u6ce2<\/span>\uff084-8Hz\uff09<\/span>\u6a21\u5f0f\u4fdd\u7559\u4e86\u5173\u4e8e\u56de\u5fc6\u989c\u8272\u7684\u4fe1\u606f\uff0c\u800c\u8179\u4fa7\u533a\u57df\u7684\u03b1\u6ce2<\/span>\uff088-13Hz\uff09<\/span>\u6a21\u5f0f\u4fdd\u7559\u4e86\u5173\u4e8e\u56de\u5fc6\u548c\u611f\u77e5\u989c\u8272\u7684\u4fe1\u606f\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fd8\u53d1\u73b0\u4fdd\u7559\u56de\u5fc6\u989c\u8272\u4fe1\u606f\u7684\u632f\u8361\u6a21\u5f0f\u5728\u524d\u989d\u53f6\u76ae\u5c42\u4e2d\u53d1\u751f\u4e86\u52a8\u6001\u53d8\u5316\u3002<\/span><\/p>\n


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\u56fe3 \u524d\u989d\u53f6\u76ae\u5c42\u795e\u7ecf\u632f\u8361\uff08\u03b2\u6ce2\uff09\u6a21\u5f0f\u4e0b\u89e3\u7801\u56de\u5fc6\u548c\u611f\u77e5\u989c\u8272\u4fe1\u606f\u7684\u6b63\u786e\u7387\u5206\u5e03\u56fe<\/span><\/section>\n


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\u8be5\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u524d\u989d\u53f6\u76ae\u5c42\u7684\u03b8\u548c\u03b2\u795e\u7ecf\u632f\u8361\u53ef\u80fd\u53c2\u4e0e\u4f7f\u5916\u90e8\u611f\u5b98\u89c6\u89c9\u8f93\u5165\u548c\u5185\u90e8\u751f\u6210\u7684\u56fe\u50cf\u4ea7\u751f\u4e0d\u540c\u610f\u8bc6\u4f53\u9a8c\u7684\u795e\u7ecf\u7f16\u7801\u3002<\/strong>\u8be5\u7814\u7a76\u8fd8\u8868\u660e\uff0c\u5728\u8ba4\u77e5\u548c\u56de\u5fc6\u5c42\u9762\uff0c\u524d\u989d\u53f6\u4e2d\u7684\u795e\u7ecf\u632f\u8361\u5728\u529f\u80fd\u4e0a\u6709\u7740\u5dee\u5f02\u5316\u7ec4\u7ec7\u3002<\/strong>\u4f7f\u7528\u9ad8\u5bc6\u5ea6\u76ae\u5c42\u8111\u7535\u56fe<\/strong>\u7684\u65b9\u6cd5\u8986\u76d6\u4e86\u76f8\u5bf9\u8f83\u5927\u7684\u76ae\u5c42\u533a\u57df\uff0c\u6709\u53ef\u80fd\u901a\u8fc7\u795e\u7ecf\u632f\u8361\u6765\u9610\u660e\u5404\u79cd\u9ad8\u7ea7\u8ba4\u77e5\u884c\u4e3a\u7684\u8be6\u7ec6\u529f\u80fd\u7ec4\u7ec7\u3002<\/span><\/p>\n


<\/p>\n

\u6b64\u5916\uff0c\u9ad8\u5bc6\u5ea6\u76ae\u5c42\u8111\u7535\u56fe\u6709\u671b\u6210\u4e3a\u4e00\u79cd\u8111\u673a\u63a5\u53e3\u65b9\u5f0f\uff0c\u7528\u4e8e\u8bfb\u53d6\u4eba\u7c7b\u7684\u8ba4\u77e5\u72b6\u6001\uff0c\u5e76\u6210\u4e3a\u8bed\u8a00\u548c\u4e66\u5199\u56f0\u96be\u60a3\u8005\uff0c\u5982\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7<\/span>\uff08amyotrophic lateral sclerosis, ALS\uff09<\/span>\u60a3\u8005\u7684\u4ea4\u6d41\u624b\u6bb5\u3002<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u539f\u6587\u94fe\u63a5\uff1a<\/span><\/section>\n<\/section>\n

https:\/\/doi.org\/10.1016\/j.celrep.2022.110676<\/p>\n<\/blockquote>\n


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\u8bfe\u9898\u7ec4\u62db\u8058<\/strong><\/strong><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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<\/strong><\/p>\n

Hisashi Tanigawa \u526f\u6559\u6388<\/span><\/span><\/section>\n


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\u535a\u58eb\u4e8e2001\u5e74\u5728\u65e5\u672c\u5927\u962a\u5927\u5b66\u533b\u5b66\u9662\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\u3002\u968f\u540e\uff0c\u4ed6\u5206\u522b\u4e8e\u65e5\u672c\u7406\u5316\u5b66\u7814\u7a76\u6240\u8111\u79d1\u5b66\u7efc\u5408\u7814\u7a76\u4e2d\u5fc3<\/span>\uff082002\u5e74\u52302006\u5e74\uff09<\/span> \u3001 \u7f8e\u56fd\u8303\u5fb7\u6bd4\u5c14\u7279\u5927\u5b66\u5fc3\u7406\u6240<\/span>\uff082007\u5e74\u52302011\u5e74\uff09<\/span>\u4ece\u4e8b\u535a\u58eb\u540e\u5de5\u4f5c\u3002\u968f\u540e\uff0c\u4ed6\u62c5\u4efb\u4e86\u65e5\u672c\u65b0\u6f5f\u5927\u5b66\u533b\u5b66\u9662\u7684\u52a9\u7406\u6559\u6388<\/span>\uff082011\u5e74\u81f32013\u5e74\uff09<\/span> \u3001 \u4ee5\u53ca\u65b0\u6f5f\u5927\u5b66\u8de8\u5b66\u79d1\u5b66\u672f\u4e2d\u5fc3\u7684\u526f\u6559\u6388<\/span>\uff082013\u5e74\u52302017\u5e74\uff09<\/span> \u3002\u57282017\u5e745\u6708\uff0c\u4ed6\u6b63\u5f0f\u52a0\u5165\u6d59\u6c5f\u5927\u5b66\u3002<\/span><\/p>\n


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\u7814\u7a76\u65b9\u5411\uff1a<\/span><\/strong><\/span><\/p>\n

\u8bfe\u9898\u7ec4\u7684\u7814\u7a76\u76ee\u6807\u662f\u5728\u7075\u957f\u7c7b\u5927\u8111\u76ae\u5c42\u4e2d\u63a2\u7d22\u9ad8\u7ea7\u8ba4\u77e5\u529f\u80fd<\/span>\uff08\u5982\u7269\u4f53\u8bc6\u522b\uff0c\u6ce8\u610f\uff0c\u5de5\u4f5c\u8bb0\u5fc6\uff0c\u957f\u65f6\u7a0b\u8bb0\u5fc6\uff09<\/span>\u80cc\u540e\u7684\u795e\u7ecf\u673a\u5236\u3002\u6211\u4eec\u7684\u7814\u7a76\u7740\u624b\u4e8e\u7315\u7334\u8179\u4fa7\u89c6\u89c9\u901a\u8def\uff0c\u4ee5\u53ca\u524d\u989d\u53f6\u76ae\u5c42\u7684\u529f\u80fd\u548c\u89e3\u5256\u7ed3\u6784\u3002\u5b9e\u9a8c\u5ba4\u5728\u7315\u7334\u4e0a\u91c7\u7528\u591a\u79cd\u5b9e\u9a8c\u6280\u672f<\/span>\uff08\u5305\u62ec\u5185\u6e90\u4fe1\u53f7\u5149\u5b66\u6210\u50cf\uff0c\u76ae\u5c42\u8111\u7535\u56fe\uff0c\u591a\u7535\u6781\u9635\u5217\u8bb0\u5f55\uff0c \u8fd1\u7ea2\u5916\u795e\u7ecf\u523a\u6fc0\uff0c\u795e\u7ecf\u793a\u8e2a\uff09<\/span>\u5f00\u5c55\u8fd9\u4e9b\u7814\u7a76\u5de5\u4f5c\u3002<\/span><\/p>\n


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\u5b9e\u9a8c\u5ba4\u4e3b\u9875\uff1a<\/span><\/section>\n<\/section>\n

http:\/\/www.ziint.zju.edu.cn\/index.php\/Index\/Czindex.html?userid=34<\/span><\/span><\/p>\n<\/blockquote>\n

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\u8bfe\u9898\u7ec4\u8bda\u8058\u535a\u58eb\u540e\u4e00\u540d\uff0c\u6b22\u8fce\u8bbf\u95ee\u4e0b\u65b9\u62db\u8058\u94fe\u63a5\uff01<\/span>\uff1a<\/span><\/section>\n<\/section>\n

http:\/\/www.<\/span>ziint.zju.edu.cn\/index.php\/join<\/span>\/zindex.html?tid=6&userid=34<\/span><\/p>\n<\/blockquote>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u8bfb\u4e66\u4f1a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u968f\u7740\u7535\u751f\u7406\u5b66\u3001\u7f51\u7edc\u5efa\u6a21\u3001\u673a\u5668\u5b66\u4e60\u3001\u7edf\u8ba1\u7269\u7406\u3001\u7c7b\u8111\u8ba1\u7b97\u7b49\u591a\u79cd\u6280\u672f\u65b9\u6cd5\u7684\u53d1\u5c55\uff0c\u6211\u4eec\u5bf9\u5927\u8111\u795e\u7ecf\u5143\u76f8\u4e92\u4f5c\u7528\u673a\u7406\u4e0e\u8fde\u63a5\u673a\u5236\uff0c\u5bf9\u610f\u8bc6\u3001\u8bed\u8a00\u3001\u60c5\u7eea\u3001\u8bb0\u5fc6\u3001\u793e\u4ea4\u7b49\u529f\u80fd\u7684\u8ba4\u8bc6\u9010\u6e10\u6df1\u5165\uff0c\u5927\u8111\u590d\u6742\u7cfb\u7edf\u7684\u8c1c\u5e95\u6b63\u5728\u88ab\u63ed\u5f00\u3002<\/span>\u4e3a\u4e86\u4fc3\u8fdb\u795e\u7ecf\u79d1\u5b66\u3001\u7cfb\u7edf\u79d1\u5b66\u3001\u8ba1\u7b97\u673a\u79d1\u5b66\u7b49\u9886\u57df\u7814\u7a76\u8005\u7684\u4ea4\u6d41\u5408\u4f5c\uff0c\u6211\u4eec\u53d1\u8d77\u4e86\u3010<\/span>\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u8bfb\u4e66\u4f1a<\/a>\u3011\u3002<\/span><\/p>\n


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\u96c6\u667a\u4ff1\u4e50\u90e8\u8bfb\u4e66\u4f1a\u662f\u9762\u5411\u5e7f\u5927\u79d1\u7814\u5de5\u4f5c\u8005\u7684\u7cfb\u5217\u8bba\u6587\u7814\u8bfb\u6d3b\u52a8\uff0c\u5176\u76ee\u7684\u662f\u5171\u540c\u6df1\u5165\u5b66\u4e60\u63a2\u8ba8\u67d0\u4e2a\u79d1\u5b66\u8bae\u9898\uff0c\u6fc0\u53d1\u79d1\u7814\u7075\u611f\uff0c\u4fc3\u8fdb\u79d1\u7814\u5408\u4f5c\u3002\u3010\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u8bfb\u4e66\u4f1a<\/a>\u3011<\/span>\u7531\u96c6\u667a\u4ff1\u4e50\u90e8\u548c\u5929\u6865\u8111\u79d1\u5b66\u7814\u7a76\u9662\u8054\u5408\u53d1\u8d77\uff0c<\/span>\u5c06\u4e8e3\u670819\u65e5\u5f00\u59cb\uff0c<\/span>\u6bcf\u5468\u516d\u4e0b\u534814:00-16:00\uff08\u6216\u6bcf\u5468\u4e94\u665a\u4e0a19:00-21:00\uff0c\u6839\u636e\u5b9e\u9645\u60c5\u51b5\u8c03\u6574\uff09\u8fdb\u884c\uff0c\u9884\u8ba1\u6301\u7eed10-12\u5468<\/span>\u3002\u671f\u95f4\u5c06\u56f4\u7ed5\u795e\u7ecf\u7f51\u7edc\u591a\u5c3a\u5ea6\u5efa\u6a21\u53ca\u5176\u5728\u8111\u75be\u75c5\u3001\u8111\u8ba4\u77e5\u65b9\u9762\u7684\u5e94\u7528\u8fdb\u884c\u7814\u8ba8\u3002<\/span><\/p>\n

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\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span>
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