{"id":34720,"date":"2022-05-27T19:45:12","date_gmt":"2022-05-27T11:45:12","guid":{"rendered":"https:\/\/swarma.org\/?p=34720"},"modified":"2022-05-27T19:45:12","modified_gmt":"2022-05-27T11:45:12","slug":"%e7%99%ab%e7%97%ab%e7%a0%94%e7%a9%b6%e4%b8%ad%e7%9a%84%e7%a5%9e%e7%bb%8f%e5%8a%a8%e5%8a%9b%e5%ad%a6%e6%a8%a1%e5%9e%8b-%e5%91%a8%e5%85%ad%e7%9b%b4%e6%92%ad%c2%b7%e7%a5%9e%e7%bb%8f%e5%8a%a8%e5%8a%9b","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=34720","title":{"rendered":"\u766b\u75eb\u7814\u7a76\u4e2d\u7684\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b | \u5468\u516d\u76f4\u64ad\u00b7\u795e\u7ecf\u52a8\u529b\u5b66\u8bfb\u4e66\u4f1a\u76f4\u64ad"},"content":{"rendered":"<div class='wxsyncmain'>\n<section style=\"font-size: 16px;\" data-mpa-powered-by=\"yiban.io\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(63, 63, 63);font-family: PingFangSC-light;font-size: 15px;background-color: rgb(255, 255, 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href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247603702&amp;idx=1&amp;sn=155301af87026492ed1591e0bb7e8c81&amp;chksm=e8960f7bdfe1866ddd8d76d5c419528f5b28bd8b69386d97eac1ec11c9ea7c3cad94453d9c2e&amp;scene=21#wechat_redirect\" textvalue=\"\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u8bfb\u4e66\u4f1a\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener noreferrer\">\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u8bfb\u4e66\u4f1a<\/a>\u3011\u3002<\/span><\/strong><\/span><\/strong><\/p>\n<p style=\"outline: 0px;clear: none;\"><br  \/><\/p>\n<section style=\"outline: 0px;clear: none;line-height: 1.75em;\"><strong style=\"letter-spacing: 0.544px;\"><span style=\"letter-spacing: 0.544px;\"><strong style=\"letter-spacing: 0.544px;\"><span style=\"letter-spacing: 0.544px;\"><strong><span style=\"letter-spacing: 0.544px;\"><strong style=\"letter-spacing: 0.544px;\"><span style=\"letter-spacing: 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both;line-height: 0;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;border-left: 3px solid rgb(33, 166, 210);border-top-color: rgb(33, 166, 210);border-right: 3px solid rgb(33, 166, 210);border-bottom-color: rgb(33, 166, 210);font-size: 16px;color: rgb(0, 0, 0);line-height: 1.4;\">\n<p style=\"outline: 0px;\"><strong style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\">\u7b80\u4ecb<\/strong><\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<section style=\"margin-right: 8px;margin-left: 8px;font-size: 16px;white-space: normal;outline: 0px;line-height: 1.75em;text-align: center;\"><br  \/><\/section>\n<h4 style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><\/h4>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u672c\u671f\u8bfb\u4e66\u4f1a\uff0c\u4ee5\u52a8\u529b\u5b66\u7cfb\u7edf\u4e3a\u89c6\u89d2\uff0c\u4ecb\u7ecd\u5e76\u63a2\u8ba8\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u5982\u4f55\u5728\u766b\u75eb\u9886\u57df\u7814\u7a76\u63d0\u4f9b\u7406\u8bba\u4e0e\u5b9e\u8df5\u652f\u6301\u3002\u766b\u75eb\u53d1\u4f5c\u4f5c\u4e3a\u4e00\u79cd\u52a8\u6001\u7684\u3001\u65f6\u7a7a\u6f14\u53d8\u7684\uff08\u7f51\u7edc\uff09\u4e34\u5e8a\u73b0\u8c61\uff0c\u6216\u53ef\u4ece\u52a8\u529b\u5b66\u89d2\u5ea6\u63a2\u8ba8\u5176\u53d1\u4f5c\u673a\u5236\uff0c\u4e3a\u766b\u75eb\u7684\u7cbe\u786e\u6cbb\u7597\u3001\u8c03\u63a7\u4ee5\u53ca\u53d1\u4f5c\u9884\u6d4b\u63d0\u4f9b\u7406\u8bba\u4e0e\u5e94\u7528\u57fa\u7840\u3002\u5177\u4f53\u4ecb\u7ecd\u766b\u75eb\u53d1\u4f5c\u7684\u56db\u4e2a\u52a8\u529b\u5b66\u6a21\u578b\uff1aWendling model, Epileptor model, Z\/Benjamin model, Theta-neuron model\u3002&nbsp;\u540c\u65f6\uff0c\u4f1a\u63a2\u8ba8\u590d\u6742\u7cfb\u7edf\u4e0e\u52a8\u529b\u5b66\u6a21\u578b\u53ef\u80fd\u5728\u766b\u75eb\u53d1\u4f5c\u9884\u6d4b\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/p>\n<p style=\"margin-bottom: 0em;font-size: 16px;white-space: normal;\"><br  \/><\/p>\n<h3 style=\"white-space: normal;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;font-family: PingFangSC-light;text-align: right;font-size: 13px;\">\n<section powered-by=\"xiumi.us\" style=\"text-align: center;\">\n<section style=\"outline: 0px;display: inline-block;vertical-align: middle;\">\n<section style=\"margin-bottom: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;clear: both;line-height: 0;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;border-left: 3px solid rgb(33, 166, 210);border-top-color: rgb(33, 166, 210);border-right: 3px solid rgb(33, 166, 210);border-bottom-color: rgb(33, 166, 210);font-size: 16px;color: rgb(0, 0, 0);line-height: 1.4;\">\n<p style=\"outline: 0px;\"><strong style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\">\u5927\u7eb2<\/strong><\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<section style=\"margin-right: 8px;margin-left: 8px;font-size: 16px;white-space: normal;outline: 0px;line-height: 1.75em;text-align: center;\"><br  \/><\/section>\n<ul class=\"list-paddingleft-1\" style=\"list-style-type: disc;\">\n<li>\n<section style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;margin-bottom: 0.5em;text-align: left;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Background on epilepsy and epilepsy surgery &#8211; where the problems are.<\/span><\/section>\n<\/li>\n<li>\n<section style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;margin-bottom: 0.5em;text-align: left;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Why we need dynamical models for epilepsy and epilepsy surgery?<\/span><\/section>\n<\/li>\n<li>\n<section style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;margin-bottom: 0.5em;text-align: left;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">What have we got so far?<\/span><\/section>\n<\/li>\n<li>\n<section style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;margin-bottom: 0.5em;text-align: left;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">What are the problems with current dynamical and non-dynamical approaches?<\/span><\/section>\n<\/li>\n<li>\n<section style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;margin-bottom: 0.5em;text-align: left;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Some perspectives from work in seizure prediction.<\/span><\/section>\n<\/li>\n<li>\n<section style=\"line-height: 1.75em;margin-left: 8px;margin-right: 8px;margin-bottom: 0.5em;text-align: left;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Some perspectives on future research<\/span><\/section>\n<\/li>\n<\/ul>\n<p style=\"margin-bottom: 0em;font-size: 16px;white-space: normal;\"><br  \/><\/p>\n<p style=\"margin-bottom: 0em;font-size: 16px;white-space: normal;\"><br  \/><\/p>\n<h3 style=\"white-space: normal;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;font-family: PingFangSC-light;text-align: right;font-size: 13px;\">\n<section powered-by=\"xiumi.us\" style=\"text-align: center;\">\n<section style=\"outline: 0px;display: inline-block;vertical-align: middle;\">\n<section style=\"margin-bottom: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;clear: both;line-height: 0;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;border-left: 3px solid rgb(33, 166, 210);border-top-color: rgb(33, 166, 210);border-right: 3px solid rgb(33, 166, 210);border-bottom-color: rgb(33, 166, 210);font-size: 16px;color: rgb(0, 0, 0);line-height: 1.4;\">\n<p style=\"outline: 0px;\"><strong style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\">\u524d\u7f6e\u77e5\u8bc6<\/strong><\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><br  \/><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: left;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">1.Jansen-Rit model<\/span><\/strong><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: 1.5em;\"><span style=\"color: rgb(63, 63, 63);font-size: 13px;\">Jansen, B. H. &amp; Rit, V. G. Electroencephalogram and visual evoked potential generation in a mathematical model of coupled cortical columns.&nbsp;Biol Cybern73, 357\u2013366 (1995).<\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: left;\"><br  \/><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: left;margin-bottom: 0.5em;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">2.Wendling model of epileptic seizures<\/span><\/strong><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: 1.5em;\"><span style=\"color: rgb(63, 63, 63);font-size: 13px;\">Wendling, F., Bartolomei, F., Bellanger, J. J. &amp; Chauvel, P. Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition.&nbsp;Eur J Neurosci15, 1499\u20131508 (2002).<\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: left;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/strong><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: left;margin-bottom: 0.5em;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">3.Z\/Benjamin model<\/span><\/strong><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: 1.5em;margin-bottom: 0.5em;\"><span style=\"color: rgb(63, 63, 63);font-size: 13px;\">Kalitzin, S. N., Velis, D. N. &amp; Silva, F. H. L. da. Stimulation-based anticipation and control of state transitions in the epileptic brain.&nbsp;Epilepsy Behav17, 310\u2013323 (2010).<\/span><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;text-align: left;line-height: 1.5em;\"><span style=\"color: rgb(63, 63, 63);font-size: 13px;\">Benjamin, O.&nbsp;et al.&nbsp;A phenomenological model of seizure initiation suggests network structure may explain seizure frequency in idiopathic generalised epilepsy.&nbsp;J Math Neurosci2, 1\u20131 (2012).<\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: left;\"><br  \/><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: left;margin-bottom: 0.5em;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">4.Epileptor (network) model<\/span><\/strong><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: left;margin-bottom: 0.5em;\"><span style=\"font-size: 13px;\"><span style=\"color: rgb(63, 63, 63);\">Jirsa, V.K., Stacey, W.C., Quilichini, P.P., Ivanov, A.I., Bernard, C., 2014.&nbsp;<\/span>On the nature of seizure dynamics<span style=\"color: rgb(63, 63, 63);\">. Brain 137, 2210\u20132230.<\/span><\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: left;\"><span style=\"color: rgb(63, 63, 63);font-size: 13px;\">Proix, T., Bartolomei, F., Guye, M. &amp; Jirsa, V. K. Individual brain structure and modelling predict seizure propagation.&nbsp;Brain140, 641\u2013654 (2017).<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: left;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/strong><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: left;margin-bottom: 0.5em;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">5.Critical transition<\/span><\/strong><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: left;\"><span style=\"color: rgb(63, 63, 63);font-size: 13px;\">Scheffer, M.&nbsp;et al.&nbsp;Anticipating Critical Transitions.&nbsp;Science338, 344\u2013348 (2012).<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: left;\"><br  \/><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: left;margin-bottom: 0.5em;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">6.Critical slowing down in human epileptic seizures<\/span><\/strong><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: left;\"><span style=\"color: rgb(63, 63, 63);font-size: 13px;\">Maturana, M. I.&nbsp;et al.&nbsp;Critical slowing down as a biomarker for seizure susceptibility.&nbsp;Nat Commun11, 2172 (2020).<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><br  \/><\/section>\n<p><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/p>\n<p style=\"margin-bottom: 0em;font-size: 16px;white-space: normal;\"><br  \/><\/p>\n<h3 style=\"white-space: normal;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;font-family: PingFangSC-light;text-align: right;font-size: 13px;\">\n<section powered-by=\"xiumi.us\" style=\"text-align: center;\">\n<section style=\"outline: 0px;display: inline-block;vertical-align: middle;\">\n<section style=\"margin-bottom: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;clear: both;line-height: 0;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;border-left: 3px solid rgb(33, 166, 210);border-top-color: rgb(33, 166, 210);border-right: 3px solid rgb(33, 166, 210);border-bottom-color: rgb(33, 166, 210);font-size: 16px;color: rgb(0, 0, 0);line-height: 1.4;\">\n<p style=\"outline: 0px;\"><strong style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\">\u4e3b\u8bb2\u4eba<\/strong><\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<section style=\"margin-right: 8px;margin-left: 8px;font-size: 16px;white-space: normal;outline: 0px;line-height: 1.75em;text-align: center;\"><br  \/><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: center;\"><img class=\"rich_pages wxw-img\" data-height=\"247\" data-ratio=\"1.0441176470588236\"  data-type=\"png\" data-w=\"544\" data-width=\"237\" style=\"width: 168px;height: 175px;\" src=\"\/wp-content\/uploads\/2022\/05\/wxsync-2022-05-78d7685bad61fdfa9b57b8654faaf201.png\"  \/><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;margin-bottom: 0.5em;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u66f9\u6dfc<\/span><\/strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\uff0c\u58a8\u5c14\u672c\u5927\u5b66\u533b\u5b66\u9662\u4e34\u5e8a\u795e\u7ecf\u79d1\u5b66\u535a\u58eb\uff0c\u5317\u4eac\u5927\u5b66\u7269\u7406\u5b66\u9662\u535a\u58eb\u540e\u3002\u535a\u58eb\u5de5\u4f5c\u53d1\u8868\u5728<em>Nature Communications<\/em>\u3002<\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7814\u7a76\u65b9\u5411\uff1a\u766b\u75eb\u624b\u672f\u672f\u524d\u8bc4\u4f30\u4e0e\u81f4\u75eb\u7076\u5b9a\u4f4d\uff0c\u7f51\u7edc\u5206\u6790\u4e0e\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\uff0c\u9885\u5185\u7535\u751f\u7406\u4e0eEEG\/MEG\/fMRI\u795e\u7ecf\u5f71\u50cf\u5206\u6790\u7b49\u3002\u81f4\u529b\u4e8e\u795e\u7ecf\u5f71\u50cf\u4e0e\u795e\u7ecf\u52a8\u529b\u5b66\u7ed3\u5408\u7684\u4e34\u5e8a\u5e94\u7528\uff0c\u4ee5\u53ca\uff08\u75c5\u7406\uff09\u795e\u7ecf\u7cfb\u7edf\u5efa\u6a21\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><br  \/><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: center;\"><img class=\"rich_pages wxw-img\" data-height=\"309\" data-ratio=\"1.4976190476190476\"  data-type=\"png\" data-w=\"420\" data-width=\"208\" style=\"width: 164px;height: 246px;\" src=\"\/wp-content\/uploads\/2022\/05\/wxsync-2022-05-22176fe34c62ac6a320d893b7b5df8ac.png\"  \/><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;margin-bottom: 0.5em;\"><strong>\u738b\u946b\u8fea<\/strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\uff0c\u73b0\u4e3a\u5317\u4eac\u6167\u8111\u4e91\u8ba1\u7b97\u6709\u9650\u516c\u53f8\u9ad8\u7ea7\u7b97\u6cd5\u7814\u53d1\u5de5\u7a0b\u5e08\u3002\u5317\u4eac\u5e08\u8303\u5927\u5b66\u8ba4\u77e5\u795e\u7ecf\u79d1\u5b66\u4e0e\u5b66\u4e60\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u535a\u58eb\uff0c\u52a0\u62ff\u5927\u9ea6\u5409\u5c14\u5927\u5b66\u8499\u7279\u5229\u5c14\u795e\u7ecf\u75c5\u5b66\u7814\u7a76\u6240\uff08Montreal Neurological Institute, MNI\uff09\u535a\u58eb\u540e\u3002\u8111\u5f71\u50cf\u9886\u57df\u5de5\u5177\u5305DPABI\/DPABISurf\u3001GERTNA\u7684\u6838\u5fc3\u5f00\u53d1\u4eba\u5458\uff0cCIVET\u3001REST\u7b49\u5de5\u5177\u5305\u7684\u4ee3\u7801\u8d21\u732e\u8005\u3002\u5728MNI\u671f\u95f4\uff0c\u53c2\u52a0\u4e86\u8111\u5f71\u50cf\u6570\u636e\u7ba1\u7406\u4e0e\u8ba1\u7b97\u5206\u6790\u5e73\u53f0LORIS\/CBrain\u7684\u5f00\u53d1\u4e0e\u7ef4\u62a4\uff0c\u662fPRIME-RE Project\u3001BigBrain Project\u3001Virtual BigBrain Project\u7b49\u8de8\u4e2d\u5fc3\u8111\u5f71\u50cf\u5927\u6570\u636e\u5408\u4f5c\u9879\u76ee\u7684\u53c2\u4e0e\u4eba\u3002Google\u5b66\u8005\u88ab\u5f15\u6b21\u65702464\u6b21\uff0cH\u6307\u657010\u3002<\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7814\u7a76\u65b9\u5411\uff1a\u591a\u6a21\u6001\u8111\u5f71\u50cf\u6570\u636e\u5206\u6790\u7b97\u6cd5\u53ca\u4fe1\u606f\u5316\u5e73\u53f0\u5efa\u8bbe\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/section>\n<h3>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;margin-bottom: 0.5em;\"><span style=\"color: rgb(33, 166, 210);\"><strong><span style=\"font-size: 15px;\">\u53c2\u8003\u6587\u732e<\/span><\/strong><\/span><\/p>\n<\/h3>\n<section style=\"margin-right: 8px;margin-left: 8px;margin-bottom: 0.5em;line-height: normal;\"><span style=\"color: rgb(63, 63, 63);font-size: 13px;\">\u5c06\u975e\u4fb5\u5165\u5f0f\u795e\u7ecf\u5f71\u50cf\u4e0e\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u7ed3\u5408\uff0c\u63d0\u4f9b\u766b\u75eb\u81f4\u75eb\u7076\u5b9a\u4f4d\u3002<\/span><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: normal;margin-bottom: 0.75em;\"><span style=\"font-size: 13px;\"><span style=\"color: rgb(63, 63, 63);\">Cao, M., Galvis, D., Vogrin, S.J.&nbsp;et al.&nbsp;<\/span>Virtual intracranial EEG signals reconstructed from MEG with potential for epilepsy surgery<span style=\"color: rgb(63, 63, 63);\">.&nbsp;Nat Commun&nbsp;13,&nbsp;994 (2022).<\/span><\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;margin-bottom: 0.5em;line-height: normal;\"><span style=\"color: rgb(63, 63, 63);font-size: 13px;\">\u8be5\u7efc\u8ff0\u7531Prof Fabrice Wendling\u7275\u5934\uff0c\u603b\u7ed3\u4e86\u8fd1\u4e9b\u5e74\u5728\u766b\u75eb\u7814\u7a76\u4e2d\u53d1\u5c55\u5e76\u4f7f\u7528\u7684\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u3002<\/span><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: normal;margin-bottom: 0.75em;\"><span style=\"font-size: 13px;\"><span style=\"color: rgb(63, 63, 63);\">Wendling, F., Bartolomei, F., Mina, F., Huneau, C. &amp; Benquet, P.&nbsp;<\/span>Interictal spikes, fast ripples and seizures in partial epilepsies&#8211;combining multi-level computational models with experimental data<span style=\"color: rgb(63, 63, 63);\">. Eur. J. Neurosci. 36, 2164\u201377 (2012).<\/span><\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;margin-bottom: 0.5em;line-height: normal;\"><span style=\"color: rgb(63, 63, 63);font-size: 13px;\">Jirsa et al.\u63d0\u51fa\u7684\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b(Epileptor),\u53ef\u8f83\u5b8c\u6574\u5730\u4eff\u771f\u53d1\u4f5c\u8d77\u59cb\u3001\u4f20\u64ad\u4ee5\u53ca\u7ec8\u6b62\u7684\u6574\u4e2a\u72b6\u6001\u8f6c\u79fb\u8fc7\u7a0b\u3002<\/span><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: normal;margin-bottom: 0.75em;\"><span style=\"font-size: 13px;\"><span style=\"color: rgb(63, 63, 63);\">Jirsa, V.K., Stacey, W.C., Quilichini, P.P., Ivanov, A.I., Bernard, C., 2014.&nbsp;<\/span>On the nature of seizure dynamics<span style=\"color: rgb(63, 63, 63);\">. Brain 137, 2210\u20132230.<\/span><\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;margin-bottom: 0.5em;line-height: normal;\"><span style=\"color: rgb(63, 63, 63);font-size: 13px;\">\u63d0\u51fa\u4e86\u865a\u62df\u5207\u9664\u6280\u672f\u4e0e\u52a8\u529b\u5b66\u6a21\u578b\u76f8\u7ed3\u5408\uff0c\u5e76\u5e94\u7528\u4e8e\u771f\u5b9e\u75c5\u4eba\u6570\u636e\u3002<\/span><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: normal;margin-bottom: 0.75em;\"><span style=\"font-size: 13px;\"><span style=\"color: rgb(63, 63, 63);\">Goodfellow, M. et al.&nbsp;<\/span>Estimation of brain network ictogenicity predicts outcome from epilepsy surgery<span style=\"color: rgb(63, 63, 63);\">. Sci. Rep. 6, 29215 (2016).<\/span><\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;margin-bottom: 0.5em;line-height: normal;\"><span style=\"color: rgb(63, 63, 63);font-size: 13px;\">\u4f7f\u7528\u4e86\u9885\u5185\u7535\u751f\u7406\u7684\u80cc\u666f\u6d3b\u52a8\u4fe1\u53f7\uff0c\u5e76\u91cd\u590d\u3001\u9a8c\u8bc1\u4e86\u865a\u62df\u5207\u9664\u4e0e\u52a8\u529b\u5b66\u6a21\u578b\u76f8\u7ed3\u5408\u7684\u5de5\u4f5c\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;margin-bottom: 0.5em;line-height: normal;\"><span style=\"font-size: 13px;\"><span style=\"color: rgb(63, 63, 63);\">Sinha, N.&nbsp;et al.&nbsp;<\/span>Predicting neurosurgical outcomes in focal epilepsy patients using computational modelling<span style=\"color: rgb(63, 63, 63);\">.&nbsp;Brain&nbsp;140, 319\u2013332 (2017).<\/span><\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;font-size: 16px;white-space: normal;line-height: 1.75em;\"><br  \/><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: center;\"><br  \/><\/p>\n<h3>\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;font-family: PingFangSC-light;text-align: right;font-size: 13px;\">\n<section powered-by=\"xiumi.us\" style=\"text-align: center;\">\n<section style=\"outline: 0px;display: inline-block;vertical-align: middle;\">\n<section style=\"margin-bottom: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;clear: both;line-height: 0;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;border-left: 3px solid rgb(33, 166, 210);border-top-color: rgb(33, 166, 210);border-right: 3px solid rgb(33, 166, 210);border-bottom-color: rgb(33, 166, 210);font-size: 16px;color: rgb(0, 0, 0);line-height: 1.4;\">\n<p style=\"outline: 0px;\"><strong style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\">\u76f4\u64ad\u4fe1\u606f<\/strong><\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<section style=\"margin-right: 8px;margin-left: 8px;outline: 0px;line-height: 1.75em;\"><br  \/><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u65f6\u95f4\uff1a<\/span><\/strong><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;color: rgb(63, 63, 63);font-size: 15px;\">2022\u5e745\u670828\u65e5\uff08\u672c\u5468\u516d\uff09\u4e0b\u534814:00-16:00<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><br  \/><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u53c2\u4e0e\u65b9\u5f0f\uff1a<\/span><\/strong><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;margin-bottom: 0.5em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">1.&nbsp;\u6587\u672b\u626b\u7801\u53c2\u4e0e<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247603702&amp;idx=1&amp;sn=155301af87026492ed1591e0bb7e8c81&amp;chksm=e8960f7bdfe1866ddd8d76d5c419528f5b28bd8b69386d97eac1ec11c9ea7c3cad94453d9c2e&amp;scene=21#wechat_redirect\" textvalue=\"\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u8bfb\u4e66\u4f1a\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener noreferrer\">\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u8bfb\u4e66\u4f1a<\/a>\uff0c\u52a0\u5165\u7fa4\u804a\uff0c\u83b7\u53d6\u7cfb\u5217\u8bfb\u4e66\u4f1a\u56de\u770b\u6743\u9650\uff0c\u6210\u4e3a\u795e\u7ecf\u52a8\u529b\u5b66\u793e\u533a\u7684\u79cd\u5b50\u7528\u6237\uff0c\u4e0e480\u4f59\u4f4d\u795e\u7ecf\u52a8\u529b\u5b66\u793e\u533a\u7684\u4e00\u7ebf\u79d1\u7814\u5de5\u4f5c\u8005\u4e0e\u4f01\u4e1a\u5b9e\u8df5\u8005\u6c9f\u901a\u4ea4\u6d41\uff0c\u5171\u540c\u63a8\u52a8\u795e\u7ecf\u52a8\u529b\u5b66\u7684\u53d1\u5c55<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\u62a5\u540d\u672c\u6b21\u8bfb\u4e66\u4f1a\uff0c\u626b\u63cf\u6587\u672b\u4e8c\u7ef4\u7801\u62a5\u540d\u6574\u5b63\u8bfb\u4e66\u4f1a\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0em;text-align: center;\"><img class=\"rich_pages wxw-img\" data-height=\"179\" data-ratio=\"1\"  data-type=\"png\" data-w=\"400\" data-width=\"179\" style=\"width: 137px;height: 137px;\" src=\"\/wp-content\/uploads\/2022\/05\/wxsync-2022-05-b721763cc7100c79312256d5e0da65c2.png\"  \/><\/p>\n<p style=\"margin-bottom: 0em;text-align: center;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">\u626b\u7801\u62a5\u540d<\/span><\/p>\n<p style=\"margin-bottom: 0em;text-align: center;\"><br  \/><\/p>\n<\/section>\n<section style=\"font-size: 16px;\">\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;text-align: center;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\"><\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;font-size: 16px;white-space: normal;line-height: 1.75em;\"><br  \/><\/section>\n<section data-mpa-template=\"t\" mpa-from-tpl=\"t\">\n<section powered-by=\"xiumi.us\" mpa-from-tpl=\"t\" style=\"margin-top: 10px;text-align: center;justify-content: center;\">\n<section mpa-from-tpl=\"t\" style=\"display: inline-block;width: auto;vertical-align: top;min-width: 10%;height: auto;box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-bottom: 9px solid rgb(169, 215, 227);border-bottom-right-radius: 0px;\">\n<section powered-by=\"xiumi.us\" mpa-from-tpl=\"t\" style=\"margin-bottom: -15px;\">\n<section mpa-from-tpl=\"t\" style=\"padding-right: 10px;padding-left: 10px;color: rgb(12, 130, 169);line-height: 2;letter-spacing: 3px;\">\n<p><strong mpa-from-tpl=\"t\">\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u8bfb\u4e66\u4f1a\u542f\u52a8<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><br  \/><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u672c\u7740\u4fc3\u8fdb\u795e\u7ecf\u79d1\u5b66\u3001\u7cfb\u7edf\u79d1\u5b66\u4ee5\u53ca\u8ba1\u7b97\u673a\u79d1\u5b66\u7b49\u4e0d\u540c\u9886\u57df\u7684\u5b66\u672f\u5de5\u4f5c\u8005\u7684<strong>\u4ea4\u6d41\u4e0e\u5408\u4f5c<\/strong>\uff0c<strong>\u6fc0\u53d1<\/strong>\u6709\u5fd7\u4e8e\u52a0\u5165\u8111\u79d1\u5b66\u4e0e\u7c7b\u8111\u7814\u7a76\u8fd9\u4e00\u9886\u57df\u7684\u540c\u5b66\u4eec\u7684<strong>\u7814\u7a76\u5174\u8da3<\/strong>\uff0c\u96c6\u667a\u4ff1\u4e50\u90e8\u548c\u5929\u6865\u8111\u79d1\u5b66\u7814\u7a76\u9662\u8054\u5408\u53d1\u8d77\u4e86<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247603702&amp;idx=1&amp;sn=155301af87026492ed1591e0bb7e8c81&amp;chksm=e8960f7bdfe1866ddd8d76d5c419528f5b28bd8b69386d97eac1ec11c9ea7c3cad94453d9c2e&amp;scene=21#wechat_redirect\" textvalue=\"\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u8bfb\u4e66\u4f1a\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener noreferrer\">\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u8bfb\u4e66\u4f1a<\/a>\u3002<strong>\u805a\u7126\u4e8e<\/strong>\u795e\u7ecf\u79d1\u5b66\u4e2d\u7684\u52a8\u529b\u5b66\u5efa\u6a21\u8fd9\u4e00\u524d\u6cbf\u8bfe\u9898\uff0c\u56f4\u7ed5\u795e\u7ecf\u7f51\u7edc\u591a\u5c3a\u5ea6\u5efa\u6a21\u53ca\u5176\u5728\u8111\u75be\u75c5\u3001\u8111\u8ba4\u77e5\u65b9\u9762\u7684\u5e94\u7528\u8fdb\u884c\u7814\u8ba8\u3002\u8bfb\u4e66\u4f1a\u5df2\u4e8e2022\u5e743\u670819\u65e5\u5f00\u59cb\uff0c\u6bcf\u5468\u516d\u4e0b\u534814:00-16:00\uff08\u6216\u6bcf\u5468\u4e94\u665a\u4e0a19:00-21:00\uff0c\u6839\u636e\u5b9e\u9645\u60c5\u51b5\u8c03\u6574\uff09\u8fdb\u884c\uff0c\u9884\u8ba1\u6301\u7eed10-12\u5468\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 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