{"id":34807,"date":"2022-05-30T20:45:17","date_gmt":"2022-05-30T12:45:17","guid":{"rendered":"https:\/\/swarma.org\/?p=34807"},"modified":"2022-05-30T20:45:17","modified_gmt":"2022-05-30T12:45:17","slug":"%e7%94%9f%e5%91%bd%e7%9a%84%e5%85%b3%e9%94%ae%e4%b8%80%e6%ad%a5%ef%bc%9a%e8%af%95%e7%ae%a1%e4%b8%ad%e7%9a%84rna%ef%bc%8c%e8%87%aa%e5%8f%91%e6%bc%94%e5%8c%96%e6%88%90%e5%be%ae%e5%9e%8b%e7%94%9f","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=34807","title":{"rendered":"\u751f\u547d\u7684\u5173\u952e\u4e00\u6b65\uff1a\u8bd5\u7ba1\u4e2d\u7684RNA\uff0c\u81ea\u53d1\u6f14\u5316\u6210\u5fae\u578b\u751f\u6001\u7cfb\u7edf"},"content":{"rendered":"
\n
\n
\n
\n
\n

<\/p>\n<\/section>\n

\n
\n
\n
\n
\n
\n

<\/section>\n<\/section>\n
\n
\n

\u5bfc\u8bed<\/strong><\/p>\n<\/section>\n<\/section>\n

\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

\u5728\u751f\u547d\u521d\u59cb\u4e4b\u65f6\uff0c\u7b80\u5355\u7684\u5206\u5b50\u7f51\u7edc\u4ee5\u67d0\u79cd\u65b9\u5f0f\u5f00\u59cb\u6f14\u5316\uff0c\u9010\u6e10\u53d8\u5f97\u591a\u6837\u590d\u6742\u3002\u8fd9\u4e00\u5207\u662f\u5982\u4f55\u53d1\u751f\u7684\u5462\uff1f\u901a\u8fc7\u89c2\u5bdf\u8bd5\u7ba1\u4e2d RNA \u5206\u5b50\u7684\u6f14\u5316\uff0c\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u81ea\u5df1\u627e\u5230\u4e86\u53ef\u80fd\u7684\u7ebf\u7d22\uff1a\u4ed6\u4eec\u6784\u5efa\u51fa\u4e00\u79cd\u5177\u6709\u590d\u5236\u80fd\u529b\u7684 RNA \u5206\u5b50\uff0c\u968f\u7740\u65f6\u95f4\u63a8\u79fb\uff0c\u8fd9\u4e9b\u5206\u5b50\u6f14\u5316\u6210\u4e00\u4e2a\u5305\u542b\u201c\u5bbf\u4e3b\u201d\u4e0e\u201c\u5bc4\u751f\u7269\u201d\u7684\u590d\u6742\u7f51\u7edc\uff0c\u4e3a\u4e86\u751f\u5b58\u5f7c\u6b64\u7ade\u4e89\uff0c\u4e5f\u76f8\u4e92\u5408\u4f5c\u3002<\/span><\/strong><\/p>\n

<\/span><\/section>\n


<\/p>\n

\u7814\u7a76\u9886\u57df\uff1aRNA\u4e16\u754c\uff0c\u5206\u5b50\u7f51\u7edc\uff0c\u81ea\u590d\u5236\uff0c\u5408\u4f5c\u6f14\u5316\uff0c\u751f\u547d\u8d77\u6e90\uff0c\u751f\u547d\u590d\u6742\u6027<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
\n

Yasemin Saplakoglu<\/span> | \u4f5c\u8005<\/strong><\/span><\/strong><\/p>\n

\u90ed\u745e\u4e1c<\/span> | \u8bd1\u8005<\/strong><\/span><\/strong><\/span><\/p>\n

\u8d75\u96e8\u4ead\u3001\u6881\u91d1<\/span> | \u5ba1\u6821<\/strong><\/span><\/strong><\/span><\/strong><\/span><\/p>\n

\u9093\u4e00\u96ea<\/span> | \u7f16\u8f91<\/strong><\/span><\/p>\n<\/section>\n


<\/p>\n


<\/section>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

1. RNA\u5206\u5b50\u81ea\u53d1\u6f14\u5316\u51fa\u590d\u6742\u6027<\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u65e5\u672c\u79d1\u5b66\u5bb6\u8fdb\u884c\u4e86\u4e00\u9879\u5bf9\u751f\u547d\u8d77\u6e90\u7814\u7a76\u5177\u6709\u8bf1\u4eba\u610f\u4e49\u7684\u6f2b\u957f\u5b9e\u9a8c\uff0c\u7814\u7a76\u4eba\u5458\u521b\u9020\u4e86\u4e00\u4e2a\u7531\u5206\u5b50\u7ec4\u6210\u7684\u8bd5\u7ba1\u4e16\u754c\uff0c\u8fd9\u4e9b\u5206\u5b50\u81ea\u53d1\u5730\u6f14\u5316\u51fa\u4e86\u590d\u6742\u6027<\/strong>\u2014\u2014\u66f4\u4ee4\u4eba\u60ca\u8bb6\u7684\u662f\uff0c\u4e5f\u540c\u65f6\u6f14\u5316\u51fa\u4e86\u5408\u4f5c<\/strong>\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u8fd9\u9879\u7814\u7a76\u7684\u4e3b\u8981\u4f5c\u8005\u3001\u4e1c\u4eac\u5927\u5b66\u52a9\u7406\u6559\u6388 Ryo Mizuuchi \u8868\u793a\uff0c\u7ecf\u8fc7\u6570\u767e\u4e2a\u5c0f\u65f6\u7684\u590d\u5236\uff0c\u4e00\u79cd RNA \u6f14\u5316\u6210\u4e86\u4e94\u79cd\u4e0d\u540c\u7684\u5206\u5b50\u79cd\u7c7b\uff0c\u5305\u542b\u5bbf\u4e3b\u548c\u5bc4\u751f\u8005\uff0c\u5b83\u4eec\u548c\u8c10\u5171\u5b58\uff0c\u5408\u4f5c\u5171\u751f\uff0c\u5c31\u50cf\u4e00\u4e2a\u201c\u5206\u5b50\u7248\u672c\u7684\u751f\u6001\u7cfb\u7edf\u201d\u7684\u8d77\u59cb\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\n
Ryo Mizuuchi \u5b9e\u9a8c\u5ba4\uff1ahttps:\/\/oolen.org\/2020\/12\/22\/ryo-mizuuchi\/<\/span><\/section>\n<\/blockquote>\n
 <\/span><\/section>\n
\u4ed6\u4eec\u7684\u5b9e\u9a8c\u8bc1\u5b9e\u4e86\u5148\u524d\u7684\u7406\u8bba\u53d1\u73b0\uff0c\u8868\u660e\u5177\u6709\u590d\u5236\u80fd\u529b\u7684\u5206\u5b50\u53ef\u4ee5\u901a\u8fc7\u8fbe\u5c14\u6587\u6f14\u5316\u81ea\u53d1\u5730\u53d1\u5c55\u51fa\u590d\u6742\u6027<\/strong>\uff0c\u8fd9\u662f\u751f\u547d\u51fa\u73b0\u7684\u5173\u952e\u4e00\u6b65\u3002\u201c\u6211\u4eec\u53ef\u4ee5\u63d0\u4f9b\u76f4\u63a5\u7684\u8bc1\u636e\uff0c\u53ef\u4ee5\u770b\u5230\u5f53\u4e00\u4e2a\u5206\u5b50\u5728\u8bd5\u7ba1\u4e2d\u53d8\u5f97\u66f4\u590d\u6742\u65f6\uff0c\u5b9e\u9645\u4e0a\u4f1a\u53d1\u751f\u4ec0\u4e48\u201d\uff0cMizuuchi \u8868\u793a\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u8fd9\u662f\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u6f14\u5316\u4ea7\u751f\u590d\u5236\u56e0\u5b50<\/span>\uff08replicators\uff09<\/span>\u7ec4\u6210\u7684\u590d\u6742\u7f51\u7edc\u7684\u7b2c\u4e00\u6b65\uff0c\u4e5f\u53ef\u80fd\u662f\u6700\u91cd\u8981\u7684\u4e00\u6b65\uff0c\u683c\u7f57\u5b81\u6839\u5927\u5b66\u7cfb\u7edf\u5316\u5b66\u6559\u6388 Sijbren Otto \u8868\u793a\u3002\u201c\u6709\u4e86\u8be5\u7814\u7a76\u6240\u5c55\u793a\u7684\u7ed3\u679c\uff0c\u524d\u65b9\u7684\u9053\u8def\u53d8\u5f97\u66f4\u52a0\u6e05\u6670\uff0c\u4eba\u4eec\u5bf9RNA\u5206\u5b50\u81ea\u6f14\u5316\u80fd\u591f\u771f\u6b63\u5b9e\u73b0\u53d8\u5f97\u66f4\u52a0\u4e50\u89c2\u3002\u201d\u4f26\u6566\u5927\u5b66\u5b66\u9662\u7684\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6 Joana Xavier \u79f0\u8d5e\u8fd9\u9879\u5de5\u4f5c\u4e3a\u5bf9\u4e00\u4e2a\u6700\u5c0f\u7cfb\u7edf\u5982\u4f55\u53d8\u5f97\u590d\u6742\u7684\u201c\u4f1f\u5927\u7684\u6982\u5ff5\u8bc1\u660e\u201d\u3002\u5979\u8868\u793a\uff0c\u8fd9\u662f\u201c\u4e00\u4e2a\u975e\u5e38\u91cd\u5927\u7684\u8fdb\u5c55\u201d\u3002<\/span><\/section>\n
 <\/span><\/section>\n

\n

<\/span><\/section>\n<\/h1>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

2. \u4ece\u65af\u76ae\u5c14\u66fc\u5996\u8bf4\u8d77<\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u65b0\u5b9e\u9a8c\u7684\u6839\u6e90\u53ef\u4ee5\u8ffd\u6eaf\u523020\u4e16\u7eaa60\u5e74\u4ee3\uff0c\u5f53\u65f6\u5206\u5b50\u751f\u7269\u5b66\u5bb6\u65af\u76ae\u5c14\u66fc<\/span>\uff08Sol Spiegelman\uff09<\/span>\u5728\u5b9e\u9a8c\u5ba4\u91cc\u521b\u9020\u4e86\u4ed6\u6240\u8c13\u7684\u201c\u5c0f\u5996\u602a\u201d\u3002\u5c3d\u7ba1\u8fd9\u4e2a\u540d\u5b57\u6709\u300a\u5f17\u5170\u80af\u65af\u5766\u300b\u7684\u6697\u793a\uff0c\u4f46\u4ed6\u7684\u5c0f\u5996\u602a\u5e76\u4e0d\u662f\u7eff\u8272\u3001\u65b9\u7709\u4e14\u5486\u54ee\u7684\uff0c\u751a\u81f3\u4e0d\u662f\u6d3b\u7269\u2014\u2014\u5b83\u662f\u4e00\u79cd\u5408\u6210\u5206\u5b50\uff0c\u5728\u8bd5\u7ba1\u4e2d\u81ea\u6211\u590d\u5236\u3002<\/span><\/section>\n
 <\/span><\/section>\n
<\/section>\n

\u56fe1. 20\u4e16\u7eaa60\u5e74\u4ee3\uff0c\u5206\u5b50\u751f\u7269\u5b66\u5bb6\uff08Sol Spiegelman\uff09\u4f7f\u7528\u4e00\u79cd\u4ed6\u79f0\u4e4b\u4e3a\u201c\u5c0f\u5996\u602a\u201d\u7684\u4e0d\u65ad\u6f14\u5316\u7684\u75c5\u6bd2RNA\u94fe\uff0c\u9996\u6b21\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u8bba\u8bc1\u4e86\u8fbe\u5c14\u6587\u7684\u81ea\u7136\u6f14\u5316\u7406\u8bba\u3002| \u6765\u6e90\uff1aThe National Library of Medicine\/National Institutes of Health<\/span><\/p>\n

 <\/span><\/section>\n
\u65af\u76ae\u5c14\u66fc\u5996\u662f\u4e00\u4e2a\u57fa\u4e8e\u75c5\u6bd2\u57fa\u56e0\u7ec4\u7684\u53d8\u5f02 RNA\u3002\u8fd9\u4f4d\u751f\u7269\u5b66\u5bb6\u53d1\u73b0\uff0c\u53ef\u4ee5\u901a\u8fc7\u7b80\u5355\u7684\u52a0\u70ed\u548c\u6df7\u5408\uff0c\u5728\u6838\u82f7\u9178\u6784\u5efa\u5757\u548c\u4e00\u79cd\u53eb\u505a\u590d\u5236\u9176\u7684\u805a\u5408\u9176\u7684\u5b58\u5728\u4e0b\uff0c\u65e0\u9650\u590d\u5236\u5b83\u3002\u7136\u800c\uff0c\u4ed6\u5f88\u5feb\u610f\u8bc6\u5230\uff0c\u968f\u7740\u65f6\u95f4\u63a8\u79fb\uff0c\u4ed6\u7684\u5206\u5b50\u53d8\u5f97\u8d8a\u6765\u8d8a\u5c0f\uff1a\u53bb\u9664\u4e0d\u5fc5\u8981\u57fa\u56e0\u7684\u590d\u5236\u54c1\u590d\u5236\u5f97\u66f4\u5feb<\/strong>\uff0c\u8fd9\u589e\u52a0\u4e86\u5b83\u4eec\u88ab\u6536\u96c6\u5230\u6837\u672c\u4e2d\u5e76\u8f6c\u79fb\u5230\u65b0\u8bd5\u7ba1\u4e2d\u8fdb\u884c\u8fdb\u4e00\u6b65\u590d\u5236\u7684\u673a\u4f1a\u3002\u5c31\u50cf\u73b0\u5b58\u7269\u79cd\u4e00\u6837\uff0c\u4ed6\u7684\u5206\u5b50\u5728\u81ea\u7136\u9009\u62e9\u538b\u529b\u4e0b\u5f00\u59cb\u53d8\u5f02\u548c\u6f14\u5316\uff0c\u4ee5\u4fbf\u66f4\u597d\u5730\u5728\u5b83\u4eec\u7684\u73bb\u7483\u4e16\u754c\u4e2d\u751f\u5b58\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u8fd9\u4e9b\u7814\u7a76\u662f\u4e16\u754c\u4e0a\u9996\u6b21\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u5bf9\u8fbe\u5c14\u6587\u6f14\u5316\u8bba\u2014\u2014\u81ea\u7136\u9009\u62e9\u5f0f\u7684\u6f14\u5316\uff0c\u9002\u8005\u751f\u5b58\u2014\u2014\u7ed9\u51fa\u5b9e\u9a8c\u6027\u8bc1\u660e\uff0c\u7f8e\u56fd\u56fd\u5bb6\u536b\u751f\u7814\u7a76\u9662\u517c\u7f8e\u56fd\u56fd\u5bb6\u751f\u7269\u6280\u672f\u4fe1\u606f\u4e2d\u5fc3\u7684\u6770\u51fa\u7814\u7a76\u5458 EugeneKoonin  \u8868\u793a\uff0c\u201c\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u9002\u8005\u751f\u5b58\u610f\u5473\u7740\u6700\u5feb\u7684\u590d\u5236\u3002\u201d<\/span><\/section>\n
 <\/span><\/section>\n
Spiegelman \u7684\u5de5\u4f5c\u542f\u53d1\u4e86\u6301\u7eed\u6570\u5341\u5e74\u7684\u8fdb\u4e00\u6b65\u7814\u7a76\uff0c\u5176\u4e2d\u5927\u90e8\u5206\u662f\u5173\u4e8e\u751f\u547d\u8d77\u6e90\u7684\u57fa\u7840\u7814\u7a76\uff0c\u5e76\u4e3a\u751f\u547d\u8d77\u6e90\u4e8e\u81ea\u590d\u5236 RNA \u5206\u5b50\u7684 \u201cRNA\u4e16\u754c\u201d\u5047\u8bf4\u63d0\u4f9b\u4e86\u652f\u6301\u3002\u4f46\u8fd9\u4e9b\u7814\u7a76\u7559\u4e0b\u4e86\u4e00\u4e2a\u5173\u952e\u95ee\u9898\uff1a\u5355\u4e2a\u5206\u5b50\u590d\u5236\u56e0\u5b50\u80fd\u5426\u6f14\u53d8\u6210\u7531\u591a\u4e2a\u590d\u5236\u56e0\u5b50\u7ec4\u6210\u7684\u590d\u6742\u7f51\u7edc\uff1f<\/strong><\/span><\/section>\n
 <\/span><\/section>\n
\u5927\u7ea6\u5341\u5e74\u524d\uff0c\u5f53 Norikazu Ichihashi \u8fd8\u662f\u65e5\u672c\u5927\u5742\u5927\u5b66\u751f\u7269\u4fe1\u606f\u5de5\u7a0b\u526f\u6559\u6388\u7684\u65f6\u5019\uff0c\u4ed6\u5f00\u59cb\u6539\u8fdb Spiegelman \u7684\u8bd5\u7ba1\u4e16\u754c\uff0c\u5c06\u7cfb\u7edf\u5f00\u53d1\u5f97\u66f4\u52a0\u63a5\u8fd1\u771f\u5b9e\u73af\u5883\uff0c\u6765\u5bfb\u627e\u7b54\u6848\u3002<\/span><\/section>\n
 <\/span><\/section>\n
Ichihashi \u548c\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd RNA \u5206\u5b50\uff0c\u5b83\u53ef\u4ee5\u7f16\u7801\u4e00\u79cd\u590d\u5236\u9176\uff0c\u8fd9\u79cd\u590d\u5236\u9176\u53ef\u4ee5\u590d\u5236 RNA\u3002\u4f46\u662f\u4e3a\u4e86\u8ba9\u5206\u5b50\u7ffb\u8bd1\u81ea\u5df1\u7684\u9057\u4f20\u5bc6\u7801\uff0c\u79d1\u5b66\u5bb6\u9700\u8981\u6dfb\u52a0\u66f4\u591a\u4e1c\u897f\uff1a\u6838\u7cd6\u4f53\u548c\u5176\u4ed6\u57fa\u56e0\u7ffb\u8bd1\u673a\u5668\uff0c\u8fd9\u4e9b\u90fd\u662f\u4ece\u5927\u80a0\u6746\u83cc\u4e2d\u501f\u8fc7\u6765\u7684\u3002\u7814\u7a76\u4eba\u5458\u5c06\u8fd9\u4e9b\u7ec6\u80de\u5668\u5d4c\u5165\u6db2\u6ef4\u4e2d\uff0c\u5e76\u5c06\u5176\u52a0\u5165\u7531 RNA \u548c\u539f\u6750\u6599\u7ec4\u6210\u7684\u6df7\u5408\u7269\u4e2d\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u63a5\u4e0b\u6765\u5c31\u662f\u6570\u5e74\u5355\u8c03\u4e4f\u5473\u7684\u6df7\u5408\u548c\u7b49\u5f85\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u4ed6\u4eec\u7684\u6f2b\u957f\u5b9e\u9a8c\u5305\u62ec\u572837\u2103<\/span>\uff08\u4eba\u4f53\u6216\u708e\u70ed\u590f\u65e5\u7684\u6e29\u5ea6\uff09<\/span>\u57f9\u517b\u590d\u5236\u7cfb\u7edf\uff0c\u6dfb\u52a0\u65b0\u7684\u6db2\u6ef4\u4e0e\u65b0\u9c9c\u7684\u7ffb\u8bd1\u7cfb\u7edf\uff0c\u5e76\u6405\u62cc\u6df7\u5408\u7269\u4ee5\u8bf1\u5bfc\u590d\u5236\u3002\u6bcf\u9694\u51e0\u5929\uff0c\u4ed6\u4eec\u5c31\u5206\u6790\u8bd5\u7ba1\u4e2d\u7684 RNA \u6d53\u5ea6\uff0c\u6bcf\u9694\u4e00\u5468\uff0c\u4ed6\u4eec\u5c06\u6700\u65b0\u6df7\u5408\u7269\u7684\u6837\u54c1\u51b7\u51bb\u8d77\u6765\u3002\u6bcf\u9694\u534a\u5e74\u5de6\u53f3\uff0c\u4ed6\u4eec\u5bf9\u5927\u6279\u91c7\u96c6\u7684\u6837\u672c\u8fdb\u884c\u6d4b\u5e8f\uff0c\u4ee5\u89c2\u5bdf RNA \u662f\u5426\u83b7\u5f97\u4e86\u65b0\u7a81\u53d8\u5e76\u6f14\u5316\u51fa\u65b0\u7684\u8c31\u7cfb\u3002<\/span><\/section>\n

<\/section>\n
 <\/span><\/section>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

3. \u8bd5\u7ba1\u4e2d\u7684\u6f14\u5316<\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u7ecf\u8fc7215\u5c0f\u65f6\u517143\u8f6e\u7684\u590d\u5236\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u59cb\u770b\u5230\u6709\u8da3\u7684\u7ed3\u679c\uff0c\u5e76\u5c06\u5176\u4e8e2016\u5e74\u53d1\u8868\u5728\u671f\u520a PNAS<\/em> \u4e0a\u3002\u6700\u521d\u7684 RNA \u5df2\u7ecf\u88ab\u53e6\u5916\u4e24\u4e2a RNA \u8c31\u7cfb\u6240\u53d6\u4ee3\u3002\u5176\u4e2d\u4e00\u4e2a\uff0c\u7814\u7a76\u4eba\u5458\u79f0\u4e4b\u4e3a\u201c\u5bbf\u4e3b<\/strong>\u201d\uff0c\u53ef\u4ee5\u4f7f\u7528\u81ea\u5df1\u7684\u590d\u5236\u9176\u6765\u590d\u5236\u81ea\u5df1\uff0c\u5c31\u50cf\u539f\u6765\u7684\u5206\u5b50\u4e00\u6837\uff1b\u53e6\u4e00\u4e2a\u8c31\u7cfb\u88ab\u79f0\u4e4b\u4e3a\u201c\u5bc4\u751f\u8005<\/strong>\u201d\uff0c\u9700\u8981\u501f\u7528\u5bbf\u4e3b\u7684\u57fa\u56e0\u8868\u8fbe\u673a\u5236\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\n
\u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
Host\u2013parasite oscillation dynamics and evolution in a compartmentalized RNA replication system<\/span><\/section>\n
\u8bba\u6587\u94fe\u63a5\uff1a<\/span><\/section>\n
https:\/\/www.pnas.org\/doi\/10.1073\/pnas.1524404113<\/span><\/section>\n<\/blockquote>\n
 <\/span><\/section>\n
\u5f53 Ichihashi \u548c\u540c\u4e8b\u5c06\u5b9e\u9a8c\u6269\u5c55\u5230\u8d85\u8fc7600\u5c0f\u65f6\u3001\u603b\u8ba1120\u8f6e\u590d\u5236\u65f6\uff0c\u4ed6\u4eec\u53d1\u73b0\u539f\u6765\u7684\u5bbf\u4e3b\u8c31\u7cfb\u5206\u88c2\u6210\u4e24\u4e2a\u72ec\u7acb\u7684\u5bbf\u4e3b\u8c31\u7cfb\uff0c\u5e76\u4e14\u5176\u4e2d\u4e00\u4e2a\u5bbf\u4e3b\u6f14\u5316\u51fa\u4e86\u4e24\u79cd\u622a\u7136\u4e0d\u540c\u7684\u5bc4\u751f\u7269\u79cd\u3002\u4f46\u662f\u589e\u52a0\u7684\u4e0d\u4ec5\u4ec5\u662f\u8c31\u7cfb\u6570\u91cf\uff0c\u5b83\u4eec\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u590d\u6742\u6027\u4e5f\u5728\u589e\u52a0\u3002\u8fd9\u4e9b\u5bbf\u4e3b\u5df2\u7ecf\u83b7\u5f97\u4e86\u4e00\u4e9b\u7a81\u53d8\uff0c\u5e72\u6270\u5bc4\u751f\u7269\u79cd\u52ab\u6301\u5176\u590d\u5236\u8d44\u6e90\u7684\u80fd\u529b\u2014\u2014\u4f46\u5bc4\u751f\u7269\u79cd\u4e5f\u6f14\u5316\u51fa\u4e86\u4e00\u4e9b\u7a81\u53d8\uff0c\u8d77\u5230\u4e86\u62b5\u5fa1\u8fd9\u4e9b\u963b\u788d\u7684\u4f5c\u7528\u3002\u5bbf\u4e3b\u548c\u5bc4\u751f\u7269\u4f3c\u4e4e\u662f\u5171\u540c\u6f14\u5316\u7684<\/strong>\u3002<\/span><\/section>\n
 <\/span><\/section>\n
2020\u5e74\u53d1\u8868\u4e8e eLife<\/em> \u6742\u5fd7\u7684\u4e00\u7bc7\u8bba\u6587\u6307\u51fa\uff0c\u5bc4\u751f\u7269\u79cd\u548c\u5bbf\u4e3b\u5728\u8fd9\u573a\u6f14\u5316\u519b\u5907\u7ade\u8d5b\u4e2d\uff0c\u79cd\u7fa4\u6570\u91cf\u5267\u70c8\u6ce2\u52a8\uff1a\u6bcf\u4e2a RNA \u8c31\u7cfb\u7684\u6570\u91cf\u77ed\u6682\u5730\u4e0a\u5347\u5230\u652f\u914d\u5730\u4f4d\uff0c\u4e4b\u540e\u8ba9\u4f4d\u4e8e\u53e6\u4e00\u4e2a\u3002\u201c\u5982\u679c\u4e00\u4e2a\u8c31\u7cfb\u5360\u4e3b\u5bfc\u5730\u4f4d\uff0c\u90a3\u4e48\u53e6\u4e00\u4e2a\u8c31\u7cfb\u5c31\u4f1a\u51cf\u5c11,\u201d \u4e1c\u4eac\u5927\u5b66\u7684 Ichihashi \u6559\u6388\u8868\u793a\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\n
\u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
Emergence and diversification of a host-parasite RNA ecosystem through Darwinian evolution<\/span><\/section>\n
\u8bba\u6587\u5730\u5740\uff1a<\/span><\/section>\n
https:\/\/elifesciences.org\/articles\/56038<\/span><\/section>\n<\/blockquote>\n
 <\/span><\/section>\n
\u7814\u7a76\u4eba\u5458\u7ee7\u7eed\u8fdb\u884c\u5b9e\u9a8c\uff0c\u5230\u4e86\u7b2c130\u56de\u5408\uff0c\u53e6\u4e00\u4e2a\u5bbf\u4e3b\u6f14\u5316\u4e86\uff1b\u5230\u4e86160\u56de\u5408\uff0c\u5176\u4e2d\u4e00\u4e2a\u5bc4\u751f\u7269\u79cd\u6d88\u5931\uff1b\u51e0\u8f6e\u4e4b\u540e\uff0c\u53e6\u4e00\u4e2a\u5bc4\u751f\u7269\u79cd\u51fa\u73b0\uff1b\u5230\u4e86190\u56de\u5408\uff0c\u7814\u7a76\u4eba\u5458\u53c8\u53d1\u73b0\u4e86\u4e00\u4e2a\u65b0\u7684\u60ca\u559c\uff1a\u6bcf\u4e2a\u8c31\u7cfb\u79cd\u7fa4\u7684\u5267\u70c8\u52a8\u6001\u53d8\u5316\u5f00\u59cb\u8ba9\u4f4d\u4e8e\u8f83\u5c0f\u7684\u6ce2\u52a8\u3002\u8fd9\u79cd\u7a33\u5b9a\u6027\u8868\u660e\uff0c\u8fd9\u4e9b\u8c31\u7cfb\u7684RNA\u4e0d\u518d\u4e3a\u590d\u5236\u800c\u7ade\u4e89\uff1b\u76f8\u53cd\uff0c\u5b83\u4eec\u5f00\u59cb\u4ee5\u7f51\u7edc\u7684\u5f62\u5f0f\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u5728\u51c6\u7a33\u5b9a\uff08quasi-stable\uff09\u7684\u5171\u5b58\u72b6\u6001\u4e0b\u5408\u4f5c\u3002<\/strong><\/span><\/section>\n
 <\/span><\/section>\n
Mizuuchi \u548c Ichihashi \u5bf9\u8fd9\u4e9b\u53d1\u73b0\u611f\u5230\u9707\u60ca\uff0c\u4ed6\u4eec\u57282022\u5e743\u6708\u4efd\u7684 Nature Communications <\/em>\u4e0a\u53d1\u8868\u4e86\u8fd9\u4e9b\u53d1\u73b0\u3002\u4ed6\u4eec\u548c Taro Furubayashi \u4e00\u8d77\u5c1d\u8bd5\u4e86\u8fd9\u4e9b\u5b9e\u9a8c\uff0c\u5f53\u65f6 Ichihashi \u5b9e\u9a8c\u5ba4\u53c2\u4e0e\u8fd9\u9879\u5de5\u4f5c\u7684\u535a\u58eb\u751f Taro Furubayashi\uff0c\u73b0\u5728\u5df2\u7ecf\u6210\u4e3a\u4e86\u4e1c\u4eac\u5927\u5b66\u7684\u7814\u7a76\u5458\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\n
\u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
Evolutionary transition from a single RNA replicator to a multiple replicator network<\/span><\/section>\n
\u8bba\u6587\u94fe\u63a5\uff1a<\/span><\/section>\n
https:\/\/www.nature.com\/articles\/s41467-022-29113-x<\/span><\/section>\n<\/blockquote>\n
 <\/span><\/section>\n
<\/section>\n

\u56fe2. Ryo Mizuuchi\uff0c\u4e1c\u4eac\u5927\u5b66\u7814\u7a76\u5458\u3001\u8fd9\u9879\u65b0\u7814\u7a76\u7684\u4e3b\u8981\u4f5c\u8005\u3002\u8fd9\u9879\u5de5\u4f5c\u5c55\u793a\u4e86\u5bbf\u4e3b\u548c\u5bc4\u751f\u7269\u5982\u4f55\u63a8\u52a8\u5f7c\u6b64\u6f14\u5316\u3002\u5982\u679c\u6ca1\u6709\u5bc4\u751f\u7269\uff0c\u8fd9\u79cd\u7a0b\u5ea6\u7684\u591a\u6837\u5316\u6216\u8bb8\u662f\u4e0d\u53ef\u80fd\u7684\u3002| \u6765\u6e90\uff1aRyo Mizuuchi<\/span><\/p>\n

 <\/span><\/section>\n
 <\/span><\/section>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

4. \u5408\u4f5c\u7684\u5173\u952e\u4f5c\u7528<\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

Koonin \u540c\u610f\u4ed6\u4eec\u7684\u53d1\u73b0\u662f\u60ca\u4eba\u7684\u3002\u4ed6\u8868\u793a\uff0c\u201c\u672c\u8f6e\u5b9e\u9a8c\u88c5\u7f6e\u66f4\u590d\u6742\u3001\u66f4\u771f\u5b9e\uff0c\u7ed3\u679c\u4e5f\u66f4\u590d\u6742\u548c\u4e30\u5bcc\uff0c\u4f46\u662f\u548c Spiegelman \u5b9e\u9a8c\u5f97\u51fa\u7684\u7ed3\u8bba\u5b8c\u5168\u517c\u5bb9\u201d\u3002\u4ed6\u4eec\u89c2\u5bdf\u4e86\u4e00\u79cd\u5355\u4e00\u7c7b\u578b\u7684\u5206\u5b50\u5728\u81ea\u7136\u9009\u62e9\u4e0b\u590d\u5236\u548c\u805a\u96c6\u7a81\u53d8\uff0c\u7136\u540e\u66f4\u8fdb\u4e00\u6b65\uff0c\u8ba9\u4e0d\u540c\u5206\u5b50\u5728\u5f7c\u6b64\u7684\u5f71\u54cd\u4e0b\u6f14\u5316\u6210\u4e00\u4e2a\u7fa4\u843d\u2014\u2014\u5c31\u50cf\u6d3b\u7ec6\u80de\u3001\u52a8\u7269\u6216\u4eba\u7684\u7fa4\u843d\u4e00\u6837\u3002\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u63a2\u7d22\u4e86\u8ba9\u5982\u6b64\u590d\u6742\u7684\u79cd\u7fa4\u53d8\u5f97\u7a33\u5b9a\u548c\u6301\u4e45\u7684\u89c4\u5219\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u5176\u4e2d\u4e00\u4e9b\u7ed3\u679c\u8bc1\u5b9e\u4e86\u65e9\u671f\u5b9e\u9a8c\u6027\u7814\u7a76\u5bf9\u5173\u4e8e\u75c5\u6bd2\u3001\u7ec6\u83cc\u548c\u771f\u6838\u751f\u7269\u590d\u6742\u6027\u5982\u4f55\u4ea7\u751f\u7684\u9884\u6d4b\uff0c\u4ee5\u53ca\u4e00\u4e9b\u7406\u8bba\u5de5\u4f5c\u3002\u4f8b\u5982\uff0cKoonin \u5b9e\u9a8c\u5ba4\u7684\u4e00\u9879\u7814\u7a76\u4e5f\u8868\u660e\uff0c\u5728\u590d\u6742\u6027\u7684\u6d8c\u73b0\u4e2d\uff0c\u5bc4\u751f\u7269\u79cd\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684<\/strong>\u3002\u201c\u5982\u679c\u6ca1\u6709\u5bc4\u751f\u7269\u79cd\uff0c\u8fd9\u79cd\u7a0b\u5ea6\u7684\u591a\u6837\u5316\u6216\u8bb8\u662f\u4e0d\u53ef\u80fd\u7684\uff0c\u201dKoonin \u8868\u793a\u3002\u5bc4\u751f\u7269\u79cd\u548c\u5b83\u4eec\u7684\u5bbf\u4e3b\u5f7c\u6b64\u7f6e\u4e8e\u5bf9\u65b9\u8eab\u4e0a\u7684\u6f14\u5316\u538b\u529b\u5bfc\u81f4\u53cc\u65b9\u5206\u88c2\u51fa\u65b0\u7684\u8c31\u7cfb\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\n
\u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
Inevitability of the emergence and persistence of genetic parasites caused by evolutionary instability of parasite-free states<\/span><\/section>\n
\u8bba\u6587\u94fe\u63a5\uff1a<\/span><\/section>\n
https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5715634\/<\/span><\/section>\n<\/blockquote>\n
 <\/span><\/section>\n
\u7814\u7a76\u53d1\u73b0\u7684\u4e00\u4e2a\u66f4\u4ee4\u4eba\u60ca\u8bb6\u7684\u57fa\u672c\u539f\u5219\u662f\u5408\u4f5c\u7684\u5173\u952e\u4f5c\u7528\u3002\u8fd9\u4e94\u4e2a\u8c31\u7cfb\u5c5e\u4e8e\u4e0d\u540c\u7684\u5c0f\u578b\u5408\u4f5c\u7f51\u7edc\uff0c\u6709\u4e9b\u8c31\u7cfb\u6bd4\u5176\u4ed6\u8c31\u7cfb\u66f4\u5177\u5408\u4f5c\u6027\u3002\u4f8b\u5982\uff0c\u5230\u4e86\u7b2c228\u8f6e\uff0c\u4e09\u4e2a\u5bbf\u4e3b\u4e2d\u7684\u4e00\u4e2a\u5df2\u7ecf\u6f14\u5316\u6210\u4e00\u4e2a\u201c\u8d85\u7ea7\u5408\u4f5c\u8005<\/strong>\u201d\uff0c\u53ef\u4ee5\u590d\u5236\u81ea\u5df1\u548c\u6240\u6709\u5176\u4ed6\u8c31\u7cfb\uff1b\u5176\u4ed6\u4e24\u4e2a\u5bbf\u4e3b\u53ef\u4ee5\u5404\u81ea\u590d\u5236\u81ea\u5df1\u548c\u4e00\u4e2a\u5bc4\u751f\u7269\u79cd\u3002<\/span><\/section>\n
 <\/span><\/section>\n
<\/section>\n

\u56fe3. \u5b9e\u9a8c\u5ba4\u4e2d\u7684RNA\u5206\u5b50\u6f14\u5316\u5f62\u6210\u591a\u6837\u5316\u7684\u5bbf\u4e3b\u548c\u5bc4\u751f\u7269\u79cd\uff0c\u5bc4\u751f\u7269\u79cd\u4f9d\u8d56\u5bbf\u4e3b\u7684\u9176\u8fdb\u884c\u590d\u5236\u3002<\/span><\/p>\n

 <\/span><\/section>\n
Xavier \u8868\u793a\uff0c\u957f\u671f\u4ee5\u6765\uff0c\u79d1\u5b66\u5bb6\u4eec\u4e00\u76f4\u81f4\u529b\u4e8e\u7814\u7a76\u6f14\u5316\u4e2d\u7684\u7ade\u4e89\uff0c\u4ee5\u81f3\u4e8e\u5408\u4f5c\u7684\u4f5c\u7528\u201c\u6709\u70b9\u88ab\u5ffd\u89c6\u4e86\u201d\u3002\u4ed6\u8868\u793a\uff0c\u201c\u5408\u4f5c\u4e5f\u5c06\u5f00\u59cb\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u5c24\u5176\u662f\u5728\u751f\u547d\u8d77\u6e90\u4e0a\uff0c\u56e0\u4e3a\u6709\u592a\u591a\u4e8b\u60c5\u5fc5\u987b\u4ee5\u6b63\u786e\u7684\u65b9\u5f0f\u53d1\u6325\u4f5c\u7528\uff0c\u751f\u547d\u624d\u4f1a\u51fa\u73b0\u3002\u201d<\/span><\/section>\n
 <\/span><\/section>\n
\u5728 Ichihashi \u548c\u540c\u4e8b\u4eec\u89c2\u5bdf\u7684\u7cfb\u7edf\u4e2d\uff0cRNA \u4e4b\u95f4\u7684\u5408\u4f5c\u5b8c\u5168\u96c6\u4e2d\u5728\u590d\u5236\u3002\u4f46\u7814\u7a76\u4eba\u5458\u5e0c\u671b\uff0c\u901a\u8fc7\u8c03\u6574\u8bd5\u7ba1\u5185\u7684\u81ea\u7136\u9009\u62e9\u6807\u51c6\uff0c\u6709\u53ef\u80fd\u5f3a\u5236 RNA \u6f14\u5316\u51fa\u5b8c\u5168\u4e0d\u540c\u7684\u529f\u80fd\u2014\u2014\u6bd4\u5982\u4ee3\u8c22\u3002<\/span><\/section>\n

<\/section>\n
 <\/span><\/section>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

5. \u6709\u4e86RNA\uff0c\u6f14\u5316\u5c31\u4f1a\u4e3a\u751f\u547d\u6307\u660e\u65b9\u5411<\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u52a0\u5dde\u5927\u5b66\u5723\u514b\u9c81\u5179\u5206\u6821\u751f\u7269\u5206\u5b50\u5de5\u7a0b\u7814\u7a76\u6559\u6388 David Deamer \u8868\u793a: \u201c\u79d1\u5b66\u5bb6\u4eec\u559c\u6b22\u4e92\u76f8\u6b3e\u5f85\u5bf9\u65b9\uff0c\u6700\u597d\u7684\u6b3e\u5f85\u5c31\u662f\u60ca\u5947\u3002\u201d\u4ed6\u80af\u5b9a\u4e86\u8be5\u8bba\u6587\u7684\u5de5\u4f5c\uff0c\u4f46\u540c\u65f6\u4e5f\u6307\u51fa\uff0c\u5728\u5b9e\u9a8c\u5ba4\u91cc\u53d1\u751f\u7684\u4e8b\u60c5\u53ef\u80fd\u4e0d\u4f1a\u7b49\u540c\u4e8e\u751f\u547d\u8d77\u6e90\u65f6\u7684\u5386\u53f2\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u5b9e\u9645\u4e0a\uff0cIchihashi \u5b9e\u9a8c\u5ba4\u7684\u60c5\u51b5\u5e76\u4e0d\u80fd\u53cd\u6620\u751f\u547d\u8d77\u6e90\u65f6\u7684\u60c5\u51b5\uff0c\u56e0\u4e3a\u5b9e\u9a8c\u4f9d\u8d56\u4e8e\u5927\u80a0\u6746\u83cc\u7684\u7ffb\u8bd1\u673a\u5668\u3002\u201c\u5173\u4e8e\u751f\u547d\u8d77\u6e90\u6700\u5178\u578b\u7684\u95ee\u9898\u662f\uff1a\u86cb\u767d\u8d28\u5408\u6210\u672c\u8eab\u662f\u5982\u4f55\u5f00\u59cb\u7684\uff1f\u201d\u5317\u5361\u7f57\u6765\u7eb3\u5927\u5b66\u6559\u5802\u5c71\u5206\u6821\u751f\u7269\u5316\u5b66\u4e0e\u751f\u7269\u7269\u7406\u5b66\u6559\u6388 Charlie Carter \u8bf4\u9053\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u4f46\u662f Koonin \u8ba4\u4e3a\uff0c\u5982\u679c\u7814\u7a76\u4eba\u5458\u80fd\u591f\u627e\u5230\u4e00\u79cd\u65b9\u6cd5\uff0c\u5229\u7528\u771f\u6b63\u81ea\u590d\u5236\u7684\u5206\u5b50\u7cfb\u7edf\u6765\u6f14\u5316\u590d\u6742\u6027\uff0c\u5c06\u4f1a\u770b\u5230\u4e0e\u8bba\u6587\u4e2d\u63cf\u8ff0\u7684\u7f51\u7edc\u975e\u5e38\u76f8\u4f3c\u7684\u4e1c\u897f\u3002\u201c\u81f3\u5c11\uff0c\u4ed6\u4eec\u6f02\u4eae\u5730\u8bf4\u660e\u4e86\u53ef\u80fd\u53d1\u751f\u5728\u751f\u547d\u8d77\u6e90\u65f6\u7684\u5404\u79cd\u8fc7\u7a0b\u3002\u201d\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u5bf9 Otto \u6765\u8bf4\uff0c\u8fd9\u9879\u7ed3\u679c\u8868\u660e\uff0c\u4e00\u65e6\u7814\u7a76\u4eba\u5458\u89e3\u51b3\u4e86\u5728\u8fd9\u79cd\u590d\u6742\u7a0b\u5ea6\u4e0a\u7cbe\u786e\u590d\u5236\u5206\u5b50\u7684\u95ee\u9898\uff0c\u5b83\u4eec\u5c31\u4f1a\u8fdb\u4e00\u6b65\u590d\u6742\u5316\u3002\u4ed6\u8868\u793a\uff0c\u8fd9\u4e2a\u5b9e\u9a8c\u201c\u5e76\u4e0d\u80fd\u544a\u8bc9\u4f60\u751f\u547d\u6700\u521d\u662f\u5982\u4f55\u505a\u5230\u7684\uff0c\u4f46\u662f\u4e00\u65e6\u6709\u4e86RNA\u5206\u5b50\uff0c\u6f14\u5316\u5c31\u4f1a\u4e3a\u751f\u547d\u6307\u660e\u524d\u8fdb\u7684\u65b9\u5411<\/strong>\u3002\u201d<\/span><\/section>\n
 <\/span><\/section>\n
Ichihashi \u548c\u540c\u4e8b\u4eec\u7ee7\u7eed\u4ed6\u4eec\u7684\u5de5\u4f5c\uff0c\u60f3\u770b\u770b\u662f\u5426\u80fd\u591f\u5728\u53e6\u4e00\u4e2a\u5b9e\u9a8c\u4e2d\u91cd\u5efa\u540c\u6837\u7684\u53ef\u6301\u7eed\u7f51\u7edc\uff0c\u6240\u4ee5\u4ed6\u4eec\u63d0\u53d6\u4e86\u8fd9\u4e94\u4e2a\u8c31\u7cfb\u7684\u6837\u672c\u3002\u7136\u800c\uff0c\u8fd9\u4e00\u6b21\uff0c\u4ed6\u4eec\u53d1\u73b0\uff0c\u867d\u7136\u5176\u4e2d\u56db\u4e2a\u8c31\u7cfb\u7ee7\u7eed\u590d\u5236\u5e76\u5b58\u6d3b\u4e86\u81f3\u5c1122\u8f6e\uff0c\u7b2c\u4e94\u4e2a\u8c31\u7cfb\u6d88\u5931\u4e86\u3002\u201c\u6211\u4e0d\u77e5\u9053\u4e3a\u4ec0\u4e48\uff0c\u8fd9\u662f\u4e00\u4e2a\u975e\u5e38\u5947\u602a\u7684\u73b0\u8c61\u3002\u201dIchihashi \u8868\u793a\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u4e00\u79cd\u53ef\u80fd\u6027\u662f\uff0c\u8fd9\u4e2a\u7cfb\u7edf\u6bd4\u7814\u7a76\u4eba\u5458\u60f3\u8c61\u7684\u66f4\u52a0\u590d\u6742\uff0c\u5f53\u5206\u79bb\u51fa\u8fd9\u4e94\u79cd\u8c31\u7cfb\u65f6\uff0c\u4ed6\u4eec\u6f0f\u6389\u4e86\u5bf9\u4e8e\u8fd9\u4e2a\u6d88\u5931\u8c31\u7cfb\u7684\u751f\u5b58\u81f3\u5173\u91cd\u8981\u7684\u7b2c\u516d\u4e2a\u8c31\u7cfb\u3002\u901a\u8fc7\u7406\u8bba\u6a21\u578b\uff0cIchihashi \u7684\u56e2\u961f\u8bc1\u5b9e\u4e86\u5269\u4e0b\u7684\u56db\u4e2a\u8c31\u7cfb\u53ef\u4ee5\u6301\u7eed\u548c\u76f8\u4e92\u4f9d\u5b58\u5730\u590d\u5236\uff0c\u5e76\u4e14\u7f3a\u5931\u56db\u4e2a\u8c31\u7cfb\u4e2d\u7684\u4efb\u4f55\u4e00\u4e2a\u90fd\u4f1a\u5bfc\u81f4\u81f3\u5c11\u5176\u4ed6\u4e00\u4e2a\u8c31\u7cfb\u7684\u706d\u7edd\u3002\u4ed6\u4eec\u7684\u6a21\u62df\u8fd8\u6307\u51fa\u4e86\u4e00\u8fdd\u53cd\u76f4\u89c9\u7684\u53d1\u73b0\uff1a\u6d88\u706d\u4e00\u79cd\u5bc4\u751f\u7269\u79cd\u5c06\u5bfc\u81f4\u5176\u5bbf\u4e3b\u7684\u706d\u7edd\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u4e0e\u6b64\u540c\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u7ee7\u7eed\u8fdb\u884c\u4ed6\u4eec\u4e3b\u8981\u7684\u8bd5\u7ba1\u5b9e\u9a8c\uff0c\u5e76\u7b49\u5f85\u89c2\u5bdf\u7531RNA\u7ec4\u6210\u7684\u5fae\u578b\u751f\u6001\u7cfb\u7edf\u7f51\u7edc\u662f\u5426\u4f1a\u53d8\u5f97\u66f4\u52a0\u590d\u6742\u3002\u4ed6\u4eec\u8fd8\u7528 DNA \u4ee3\u66ff RNA \u5f00\u59cb\u4e86\u7c7b\u4f3c\u5b9e\u9a8c\u3002<\/span><\/section>\n
 <\/span><\/section>\n
Ichihashi \u8868\u793a\uff0c\u6211\u4eec\u53ea\u662f\u89c2\u5bdf\u5230\u8fd9\u4e9b\u5206\u5b50\u590d\u5236\u56e0\u5b50\u7fa4\u843d\u5982\u4f55\u6f14\u5316\u7684\u5f00\u7aef\uff0c\u201c\u6211\u8ba4\u4e3a\u8fd9\u4e9bRNA\u7ec4\u6210\u7684\u5fae\u578b\u751f\u6001\u7cfb\u7edf\u5728\u672a\u6765\u4f1a\u6709\u4e0d\u540c\u7684\u547d\u8fd0\uff0c\u6211\u4eec\u65e0\u6cd5\u9884\u6d4b\u4f1a\u53d1\u751f\u4ec0\u4e48\u3002\u201d<\/span><\/section>\n
 <\/span><\/section>\n
\n
\n
\n
\u672c\u6587\u7ffb\u8bd1\u81ea<\/span>  Quanta Magazine<\/em><\/span><\/section>\n
\u539f\u6587\u9898\u76ee\uff1aIn Test Tubes, RNA Molecules Evolve Into a Tiny Ecosystem<\/span><\/section>\n
\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/www.quantamagazine.org\/in-test-tubes-rna-molecules-evolve-into-a-tiny-ecosystem-20220505\/<\/span><\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n

<\/section>\n
\n
\n
\n

<\/section>\n
\n

<\/section>\n
\n
\u7279\u7ea6\u8bc4\u8bba<\/strong><\/span><\/section>\n

<\/section>\n<\/section>\n

<\/section>\n<\/section>\n

<\/section>\n<\/section>\n
\n
\n
\n
\u8bc4\u8bba\u5458\uff1a\u4ec7\u73ae\u794e\uff08\u96c6\u667a\u7814\u7a76\u5458\uff09<\/span><\/strong><\/span><\/section>\n

<\/section>\n
\u5b9a\u5411\u8fdb\u5316\u53ef\u4ee5\u8bf4\u662f\u5206\u5b50\u751f\u7269\u5b66\u4e2d\u5bf9\u8fbe\u5c14\u6587\u81ea\u7136\u9009\u62e9\u539f\u7406\u7684\u76f4\u63a5\u5e94\u7528\uff0c\u751f\u547d\u8d77\u6e90\u7684\u7c73\u52d2\u5b9e\u9a8c\u53ca\u83b7\u5f972018\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u7684\u9176\u5b9a\u5411\u8fdb\u5316\u7814\u7a76\u662f\u5176\u4e2d\u6700\u4e3a\u5927\u5bb6\u719f\u77e5\u7684\u5178\u578b\u3002<\/span>\u672c\u6587\u4e2d\u4ecb\u7ecd\u4e86\u4ee5\u201c\u65af\u76ae\u5c14\u66fc\u5996\u201d\u4e3a\u8d77\u70b9\u7684RNA\u5b9a\u5411\u8fdb\u5316\u7814\u7a76\u7684\u7cfb\u5217\u8fdb\u5c55\uff0c\u7814\u7a76\u4eba\u5458\u5728\u4e00\u7cfb\u5217\u957f\u671f\u7684RNA\u7fa4\u4f53\u8fdb\u5316\u8bd5\u9a8c\u4e2d\u9010\u6e10\u5c55\u793a\u51fa\u201c\u81ea\u590d\u5236–>\u50ac\u5316\u7f51\u7edc–>\u751f\u6001\u7f51\u7edc\u201d\u8fd9\u6837\u590d\u6742\u5ea6\u9010\u6e10\u9012\u589e\u7684\u8d8b\u52bf\uff0c\u5e76\u53d1\u73b0\u4e86\u4e0e\u5927\u7684\u751f\u6001\u7cfb\u7edf\u4e2d\u540c\u6837\u5b58\u5728\u7684\u7ade\u4e89\u3001\u5171\u751f\u3001\u5bc4\u751f\u7b49\u590d\u6742\u7684\u7fa4\u4f53\u6f14\u5316\u7b56\u7565\uff0c\u8bf4\u660e\u57fa\u4e8e\u6a21\u7248\u7684\u7f16\u7801\u5e8f\u5217\u672c\u8eab\u5c31\u53ef\u4ee5\u6210\u4e3a\u8fbe\u5c14\u6587\u5f0f\u6f14\u5316\u7684\u57fa\u7840\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u8fd9\u4e3a\u201c\u8fbe\u5c14\u6587\u5f0f\u81ea\u7136\u9009\u62e9\u5230\u5e95\u662f\u53d1\u751f\u5728\u4e2a\u4f53\u3001\u8fd8\u662f\u7fa4\u4f53\u3001\u8fd8\u662f\u57fa\u56e0\u4e4b\u4e0a\u201d\u8fd9\u4e2a\u957f\u671f\u4ee5\u6765\u7684\u91cd\u8981\u751f\u7269\u5b66\u54f2\u5b66\u8bae\u9898\u53c8\u589e\u6dfb\u4e86\u4e00\u4e2a\u65b0\u7684\u9009\u9879\u3002\u53e6\u5916\uff0c\u8fd9\u9879\u7814\u7a76\u8fd8\u53ef\u4ee5\u6709\u4e00\u4e2a\u6709\u8da3\u7684\u89e3\u8bfb\u89c6\u89d2\uff1a\u4e00\u4e2a\u7f16\u7801\u7684\u7f51\u7edc\u4e2d\u5982\u4f55\u4ea7\u751f\u5173\u7cfb\uff0c\u800c\u8fd9\u79cd\u5173\u7cfb\u5982\u4f55\u5d4c\u5165\u7f16\u7801\u7684\u7b26\u53f7\u4f53\u7cfb\u4e2d\uff1f\u8fd9\u662f\u8bed\u4e49\u4e0e\u7b26\u53f7\u903b\u8f91\u8ba8\u8bba\u7684\u91cd\u8981\u95ee\u9898\uff0c\u4e5f\u8bb8\u672c\u5b9e\u9a8c\u80fd\u591f\u63d0\u4f9b\u4e00\u4e2a\u8ba8\u8bba\u8fd9\u4e2a\u95ee\u9898\u7684\u73b0\u5b9e\u6a21\u578b\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u6700\u540e\uff0c\u9700\u8981\u63d0\u9192\u8bfb\u8005\u6ce8\u610f\u7684\u662f\uff0c\u672c\u6587\u63d0\u5230\u7684\u7cfb\u5217\u5b9e\u9a8c\u9700\u8981\u590d\u5236\u9176\u7684\u53c2\u4e0e\u548c\u8868\u8fbe\uff0c\u56e0\u6b64\u5e76\u4e0d\u662f\u7eaf\u7cb9\u7684\u65e0\u9176RNA\u5b9a\u5411\u8fdb\u5316<\/span>\uff08Lam\u7b49\u57282009\u5e74\u9996\u6b21\u5b9e\u73b0\u65e0\u86cb\u767d\u53c2\u4e0e\u7684RNA\u81ea\u590d\u5236\u4f53\u7cfb, doi\uff1a10.1038\/nbt.1528\uff09<\/span>\u3002\u6211\u4eec\u5728\u201c\u81ea\u751f\u6210\u7ed3\u6784\u8bfb\u4e66\u4f1a<\/a>\u201d\u7684\u540e\u7eed\u6d3b\u52a8\u4e2d\uff0c\u4e5f\u5c06\u501f\u52a9\u8fd9\u4e2a\u7814\u7a76\u7684\u8bdd\u9898\u8ba8\u8bba\u6d3b\u7cfb\u7edf\u81ea\u751f\u6210\u8fc7\u7a0b\u4e2d\u201c\u751f\u547d\u4fe1\u606f\u7684\u5206\u9636\u6bb5\u751f\u6210\u201d\u7684\u8fc7\u7a0b\uff0c\u8bf7\u5927\u5bb6\u62ed\u76ee\u4ee5\u5f85\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

 <\/span><\/section>\n
\n
\n
\n
\n

\u81ea\u751f\u6210\u7ed3\u6784\u8bfb\u4e66\u4f1a\u62a5\u540d\u4e2d<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u751f\u547d\u662f\u6709\u5fc3\uff08\u610f\u8bc6\uff09\u7684\uff0c\u4f46\u5f53\u4f60\u4e00\u5c42\u5c42\u5265\u5f00\u751f\u547d\u7684\u7ec4\u7ec7\uff0c\u5374\u53ea\u6709\u5fc3\u810f\u800c\u6ca1\u6709\u4e00\u9897\u201c\u5fc3\u7075\u201d\uff1b\u6253\u5f00\u5927\u8111\u76ae\u5c42\u770b\u5230\u4e00\u4e2a\u4e2a\u795e\u7ecf\u5143\uff0c\u5374\u770b\u4e0d\u5230\u201c\u610f\u8bc6\u201d\u3002\u7136\u800c\uff0c\u751f\u547d\u4e0e\u610f\u8bc6\u90fd\u5177\u6709\u201c\u81ea\u6211\u751f\u6210\u201c\u7684\u80fd\u529b\uff0c\u751f\u547d\u81ea\u53d1\u4ece\u975e\u751f\u547d\u4e2d\u751f\u6210\uff0c\u610f\u8bc6\u81ea\u53d1\u4ece\u751f\u547d\u4e2d\u751f\u6210\u3002\u66f4\u60ca\u4eba\u7684\u662f\uff0c\u751f\u547d\u4e0e\u610f\u8bc6\u7684\u81ea\u6211\u751f\u6210\u7ed3\u6784\u4f3c\u4e4e\u5f88\u76f8\u4f3c\u3002\u5982\u679c\u8fd9\u4e2a\u5047\u8bbe\u6210\u7acb\uff0c\u90a3\u4e48\u6700\u53ef\u80fd\u7684\u5907\u9009\u7ed3\u6784\u4f1a\u662f\u4ec0\u4e48\u5462\uff1f<\/span><\/p>\n


<\/p>\n

\u4e3a\u4e86\u66f4\u6df1\u5165\u5730\u8ba4\u8bc6\u590d\u6742\u6d3b\u7cfb\u7edf\u7684\u81ea\u751f\u6210\u7ed3\u6784\uff0c\u96c6\u667a\u79d1\u5b66\u5bb6\u5c0f\u6728\u7403(\u4ec7\u73ae\u794e)\u8054\u5408\u5468\u7406\u4e7e\u3001\u738b\u4e1c\u3001\u8463\u8fbe\u3001\u5218\u5b87\u3001\u82d1\u660e\u7406\u3001\u5085\u6e25\u6210\u3001\u7ae0\u5f66\u535a\u7b49\u79d1\u5b66\u54f2\u5b66\u3001\u8ba1\u7b97\u673a\u79d1\u5b66\u3001\u7269\u7406\u5b66\u548c\u751f\u7269\u5316\u5b66\u7b49\u5b66\u79d1\u7684\u4e00\u7ebf\u7814\u7a76\u8005\u5171\u540c\u53d1\u8d77\u7ec4\u7ec7\u300a\u81ea\u751f\u6210\u7ed3\u6784\u7cfb\u5217\u8bfb\u4e66\u4f1a\u300b\u3002\u5176\u4e2d\u7b2c\u4e00\u5b63\u300a\u5171\u8bc6\u2014\u2014\u81ea\u751f\u6210\u7ed3\u6784\u4e0e\u81ea\u590d\u5236\u81ea\u52a8\u673a\u7684\u7814\u7a76\u80cc\u666f\u300b<\/a>\u5df2\u7ecf\u5b8c\u7ed3\uff0c\u8bfb\u4e66\u4f1a\u6240\u5f62\u6210\u7684\u81ea\u751f\u6210\u7ed3\u6784\u793e\u7fa4\u96c6\u7ed3\u4e86\u76f8\u5173\u9886\u57df\u7684\u6559\u6388\u3001\u7855\u535a\u53ca\u4ea7\u4e1a\u754c\u4eba\u58eb\u3002\u73b0\u5728\u62a5\u540d\u8bfb\u4e66\u4f1a\u5373\u53ef\u89e3\u9501\u7b2c\u4e00\u5b63\u8bfb\u4e66\u4f1a\u6240\u6709\u5f55\u64ad\u89c6\u9891\u5e76\u5165\u7fa4\uff0c\u6b22\u8fce\u4ece\u4e8b\u76f8\u5173\u7814\u7a76\u3001\u5bf9\u76f8\u5173\u9886\u57df\u6709\u6d53\u539a\u5174\u8da3\u7684\u63a2\u7d22\u8005\u62a5\u540d\u53c2\u4e0e\u4ea4\u6d41\u3002<\/span><\/p>\n


<\/p>\n

<\/span><\/a><\/p>\n


<\/section>\n
\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/section>\n
\u81ea\u751f\u6210\u7ed3\u6784\u8bfb\u4e66\u4f1a\u542f\u52a8\uff1a\u5256\u89e3\u751f\u547d\u3001\u610f\u8bc6\u4e0e\u667a\u80fd\u7684\u6838\u5fc3\u7ed3\u6784<\/a><\/span>
<\/section>\n


<\/p>\n


<\/p>\n

\n

\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n