{"id":35736,"date":"2022-07-09T21:57:01","date_gmt":"2022-07-09T13:57:01","guid":{"rendered":"https:\/\/swarma.org\/?p=35736"},"modified":"2022-07-09T21:57:01","modified_gmt":"2022-07-09T13:57:01","slug":"%e7%94%9f%e5%91%bd%e8%b5%b7%e6%ba%90%e5%81%87%e8%af%b4%ef%bc%9arna-%e5%a4%9a%e8%82%bd%e4%b8%96%e7%95%8c%e7%9a%84%e5%89%8d%e7%94%9f%e7%89%a9%e5%9b%be%e6%99%af","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=35736","title":{"rendered":"\u751f\u547d\u8d77\u6e90\u5047\u8bf4\uff1aRNA-\u591a\u80bd\u4e16\u754c\u7684\u524d\u751f\u7269\u56fe\u666f"},"content":{"rendered":"
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\u751f\u547d\u8d77\u6e90\u7684 RNA \u4e16\u754c\u5047\u8bf4\u8ba4\u4e3a\uff0c\u751f\u547d\u4ece\u8d8a\u6765\u8d8a\u590d\u6742\u7684\u81ea\u6211\u590d\u5236\u7684RNA\u5206\u5b50\u6f14\u5316\u800c\u6765\u3002\u53ef\u662f\u5728\u73b0\u4ee3\u4e16\u754c\uff0cRNA\u7684\u529f\u80fd\u4e3b\u8981\u6d88\u51cf\u4e3a\u4fe1\u606f\u5b58\u50a8\uff0c\u86cb\u767d\u8d28\u5219\u6210\u4e3a\u751f\u547d\u7684\u50ac\u5316\u5242\u3002\u90a3\u4e48\u6700\u521d\u7a76\u7adf\u662f\u5148\u6709\u86cb\u767d\u8d28\uff0c\u8fd8\u662f\u5148\u6709RNA\u5462\uff1f\u8fd9\u662f\u751f\u547d\u6f14\u5316\u4e2d\u6700\u795e\u79d8\u7684\u201c\u9e21\u751f\u86cb\u8fd8\u662f\u86cb\u751f\u9e21\u201d\u96be\u9898\u4e4b\u4e00\u30022022\u5e745\u6708\u53d1\u8868\u4e8e Nature<\/em> \u7684\u4e00\u9879\u6700\u65b0\u7814\u7a76\u8ba4\u4e3a\uff0c\u751f\u547d\u8d77\u6e90\u4e8e\u4e00\u4e2a\u201cRNA-\u591a\u80bd\u4e16\u754c\u201d\uff0c\u5176\u4e2dRNA\u548c\u591a\u80bd\u5171\u540c\u6f14\u5316\u51fa\u66f4\u9ad8\u7684\u590d\u6742\u6027\uff0c\u4e4b\u540e\u5206\u79bb\u521b\u9020\u51fa\u6838\u9178-\u86cb\u767d\u8d28\u7684\u4e8c\u5143\u4e16\u754c\uff0c\u8fd9\u662f\u5730\u7403\u4e0a\u6240\u6709\u751f\u547d\u4ea7\u751f\u7684\u6807\u5fd7\u3002<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/p>\n


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\u7814\u7a76\u9886\u57df\uff1a\u751f\u547d\u8d77\u6e90\uff0cRNA-\u591a\u80bd\u4e16\u754c\u5047\u8bf4<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Yasemin Saplakoglu<\/span> <\/span>| \u4f5c\u8005<\/strong><\/span><\/strong><\/span><\/strong><\/p>\n

\u6881\u680b\u680b<\/span> <\/span>| \u8bd1\u8005<\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/p>\n

\u6881\u91d1<\/span> <\/span>| \u5ba1\u6821<\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/p>\n

\u9093\u4e00\u96ea<\/span> <\/span>| <\/strong><\/span>\u7f16\u8f91<\/strong><\/p>\n


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\u56fe1. \u6d3b\u7ec6\u80de\u7684\u591a\u6838\u7cd6\u4f53\u7ed3\u6784\u5c55\u793a\u4e86\u86cb\u767d\u8d28\u5408\u6210\u6d3b\u52a8\uff0c\u6b63\u5982\u8fd9\u5f20\u663e\u5fae\u56fe\u6240\u793a\u3002\u6838\u7cd6\u4f53\uff08\u84dd\u8272\uff09\u6cbf\u7740\u4e00\u6761\u4fe1\u4f7fRNA\uff08\u54c1\u7ea2\uff09\u94fe\u79fb\u52a8\uff0c\u8bfb\u53d6\u5176\u7f16\u7801\u5185\u5bb9\u5e76\u7ec4\u88c5\u591a\u80bd\u94fe\uff08\u7eff\u8272\uff09\u3002<\/span><\/section>\n


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1. \u751f\u547d\u8d77\u6e90\uff1a\u5148\u6709RNA\u8fd8\u662f\u86cb\u767d\u8d28\uff1f<\/span><\/strong><\/strong><\/p>\n<\/section>\n

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\u5728\u751f\u547d\u8d77\u6e90\u9886\u57df\u4e2d\uff0c\u8fc7\u53bb\u51e0\u5341\u5e74\u4eba\u4eec\u4e00\u76f4\u8ba4\u4e3a\uff0c\u751f\u547d\u6700\u6df1\u3001\u6700\u53e4\u8001\u7684\u6839\u57fa\u662f\u7531RNA\u5206\u5b50\u5960\u5b9a\u7684\uff0c\u5e76\u4e14RNA\u6f14\u5316\u7684\u8d8a\u6765\u8d8a\u590d\u6742\uff0c\u8fd9\u4e00\u89c2\u70b9\u6218\u80dc\u4e86\u5176\u4ed6\u7ade\u4e89\u7406\u8bba\uff0c\u5982\u751f\u547d\u8d77\u6e90\u4e8e\u591a\u80bd\u6216DNA\u3002<\/span><\/p>\n


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\u4f46\u8fd1\u5e74\u6765\uff0c\u8fd9\u4e2a\u9886\u57df\u8f6c\u5411\u4e86\u591a\u4e3b\u89d2\u7684\u7406\u8bba\u3002\u5176\u4e2d\u6709\u4e00\u4e2a\u60f3\u6cd5\u65e5\u76ca\u6d41\u884c\uff0c\u5373RNA\u548c\u591a\u80bd\u5171\u540c\u6f14\u5316\u51fa\u590d\u6742\u6027\uff0c\u5b83\u4eec\u7684\u6df7\u5408\u6fc0\u53d1\u4e86\u6211\u4eec\u6240\u77e5\u7684\u751f\u547d\u3002<\/span><\/p>\n


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2022\u5e745\u6708\uff0c\u4e00\u9879\u53d1\u8868\u5728\u300a\u81ea\u7136\u300b\u6742\u5fd7\u4e0a\u7684\u65b0\u7814\u7a76\uff0c\u4e3a\u8bf4\u660e\u65e9\u671f\u7684RNA\u5206\u5b50\u5982\u4f55\u76f4\u63a5\u751f\u6210\u591a\u80bd\uff0c\u5c31\u597d\u6bd4\u6811\u4e0a\u751f\u51fa\u8611\u83c7\uff0c\u63d0\u51fa\u4e86\u4e00\u4e2a\u5408\u7406\u53ef\u884c\u7684\u9014\u5f84\uff0c\u8fd9\u5c31\u662f\u6240\u8c13\u7684\u201cRNA-\u591a\u80bd\u4e16\u754c<\/strong>\u201d<\/span>\uff08RNA-peptide world\uff09<\/span>\u5047\u8bf4\u3002\u8fd9\u4e9b\u591a\u80bd\u53ef\u80fd\u53cd\u4f5c\u7528\u4e8eRNA\u5206\u5b50\u4f7f\u5176\u7a33\u5b9a\uff0c\u8ba9RNA\u5206\u5b50\u6709\u7a7a\u95f4\u590d\u6742\u5316\u3002\u751f\u547d\u7684\u4e24\u4e2a\u5173\u952e\u89d2\u8272\u5c31\u8fd9\u6837\u5171\u540c\u6f14\u5316\u4e3a\u4e00\u4e2a\u6df7\u5408\u7684\u201c\u5d4c\u5408\u201d\u5206\u5b50\uff0c\u8fd9\u53ef\u80fd\u662f\u86cb\u767d\u8d28\u751f\u4ea7\u7684\u6700\u5f00\u59cb\uff0c\u5e76\u4e14\u662f\u5411\u539f\u521d\u7248\u672c\u7684\u6838\u7cd6\u4f53\u8fc8\u8fdb\u7684\u4e00\u6b65\u3002<\/span><\/p>\n


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\u8bba\u6587\u9898\u76ee\uff1a<\/span><\/p>\n

A prebiotically plausible scenario of an RNA\u2013peptide world<\/span><\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1a<\/span><\/p>\n

https:\/\/www.nature.com\/articles\/s41586-022-04676-3<\/span><\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n


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\u201c\u4e8b\u5b9e\u8bc1\u660e\uff0cRNA\u5206\u5b50\u548c\u591a\u80bd\u5b9e\u9645\u4e0a\u786e\u5b9e\u53ef\u4ee5\u4e92\u76f8\u5e2e\u52a9\u3002\u201d\u6cd5\u56fd\u65af\u7279\u62c9\u65af\u5821\u8d85\u5206\u5b50\u79d1\u5b66\u4e0e\u5de5\u7a0b\u7814\u7a76\u6240<\/span>\uff08Institute of super molecular Science and Engineering\uff09<\/span>\u7684Claudia Bonfio \u8bf4\u3002\u5979\u4e3a\u8fd9\u7bc7\u8bba\u6587\u64b0\u5199\u4e86\u4e00\u7bc7\u8bc4\u8bba\u3002\u7814\u7a76\u8868\u660e\uff0c\u751f\u6210RNA\u5206\u5b50\u548c\u591a\u80bd\u7684\u539f\u6599\u53ef\u80fd\u5728\u751f\u547d\u5f00\u59cb\u65f6\u5c31\u5df2\u7ecf\u5b58\u5728\u4e86\uff0c\u6240\u4ee5\u8fd9\u7bc7\u8bba\u6587\u7684\u89c2\u70b9\u662f\uff1a\u201c\u4e3a\u4ec0\u4e48\u6211\u4eec\u53ea\u5173\u6ce8RNA?\u201d Bonfio \u5982\u6b64\u8bf4\u9053\u3002<\/span><\/p>\n


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\u8fd9\u9879\u5de5\u4f5c\u4e3a\u63a2\u7d22\u751f\u547d\u8d77\u6e90\u5f00\u8f9f\u4e86\u65b0\u7684\u65b9\u5411\uff0c\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u7684\u5316\u5b66\u548c\u751f\u7269\u5316\u5b66\u6559\u6388 Yitzhak Tor\u8bf4\u3002\u4ed6\u6ca1\u6709\u53c2\u4e0e\u8fd9\u9879\u7814\u7a76\uff0c\u4f46\u4e0e\u4f5c\u8005\u957f\u671f\u5408\u4f5c\u3002\u201c\u73b0\u5728\u4f60\u9700\u8981\u8003\u8651\u4e24\u79cd\u4e0d\u540c\u751f\u7269\u5206\u5b50\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u201d<\/span><\/p>\n


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\u84dd\u5927\u7406\u77f3\u7a7a\u95f4\u79d1\u5b66\u7814\u7a76\u6240<\/span>\uff08Blue Marble Space Institute of Science \uff09<\/span>\u548c\u7f8e\u56fd\u5b87\u822a\u5c40\u827e\u59c6\u65af\u7814\u7a76\u4e2d\u5fc3<\/span>\uff08NASA\u2019s Ames Research Center\uff09<\/span>\u7684\u7814\u7a76\u79d1\u5b66\u5bb6 Andro Rios \u8bf4\uff0c\u8fd9\u662f\u4e00\u4e2a\u201c\u975e\u5e38\u6709\u8da3\u7684\u6f14\u793a\u201d\u3002<\/span><\/p>\n


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\u8fd9\u4e9b\u53d1\u73b0\u4e5f\u89e3\u91ca\u4e86\u56f0\u6270\u7814\u7a76\u4eba\u5458\u591a\u5e74\u7684\u9e21\u751f\u86cb\u86cb\u751f\u9e21\u96be\u9898\uff1a\u65e2\u7136\u6838\u7cd6\u4f53<\/span>\uff08\u73b0\u4ee3\u7ec6\u80de\u4e2d\u5927\u91cf\u751f\u4ea7\u86cb\u767d\u8d28\u7684\u7ec6\u80de\u5668\uff09<\/span>\u90e8\u5206\u662f\u7531\u86cb\u767d\u8d28\u7ec4\u6210\u7684\uff0c\u90a3\u4e48\u5728\u6838\u7cd6\u4f53\u6f14\u5316\u4e4b\u524d\uff0c\u86cb\u767d\u8d28\u662f\u5982\u4f55\u5f62\u6210\u7684?<\/span><\/p>\n


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2. RNA\u4e16\u754c\u7684\u6d3b\u5316\u77f3<\/span><\/strong><\/strong><\/p>\n<\/section>\n

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\u5f53\u7ec6\u80de\u9700\u8981\u5236\u9020\u86cb\u767d\u8d28\u65f6\uff0c\u5b83\u4eec\u7684\u57fa\u56e0\u4f1a\u7eba\u51fa\u957f\u957f\u7684\u4fe1\u4f7fRNA<\/span> (mRNA)<\/span>\uff0c\u7cbe\u786e\u7f16\u7801\u5236\u9020\u86cb\u767d\u8d28\u7684\u914d\u65b9\u3002\u6838\u7cd6\u4f53\u9605\u8bfb\u8fd9\u4e9b\u914d\u65b9\uff0c\u5e76\u5728\u8f6c\u79fbRNA<\/span> (tRNA) <\/span>\u5206\u5b50\u7684\u5e2e\u52a9\u4e0b\u7ec4\u88c5\u76f8\u5e94\u7684\u6c28\u57fa\u9178\u3002\u6838\u7cd6\u4f53\u5c06\u4e00\u4e2a\u751f\u957f\u7684\u80bd\u94fe\u8f6c\u79fb\u5230\u6bcf\u4e2atRNA\u5e26\u6765\u7684\u65b0\u6c28\u57fa\u9178\u4e0a\u3002\u8fd9\u4e9b\u94fe\u53d8\u5f97\u8d8a\u6765\u8d8a\u957f\uff0c\u6700\u7ec8\u6298\u53e0\u6210\u529f\u80fd\u5316\u7684\u86cb\u767d\u8d28\u3002<\/span><\/p>\n


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\u7136\u800c\uff0c35\u4ebf\u5e74\u524d\u7684\u86cb\u767d\u8d28\u4e0d\u592a\u53ef\u80fd\u4ee5\u7c7b\u4f3c\u7684\u65b9\u5f0f\u5f62\u6210\u3002tRNA\u5206\u5b50\u4e0a\u7684\u80bd\u952e\u975e\u5e38\u5f31\uff0c\u5982\u679c\u6ca1\u6709\u6838\u7cd6\u4f53\u63d0\u4f9b\u5e87\u62a4\uff0c\u6c34\u5206\u5b50\u4f1a\u5728\u591a\u80bd\u5f62\u6210\u524d\u7834\u574f\u8fd9\u4e9b\u952e\uff0c\u8fd9\u4f7f\u5f97\u4e0a\u8ff0\u86cb\u767d\u8d28\u751f\u6210\u8fc7\u7a0b\u5728\u539f\u59cb\u4e16\u754c\u6076\u52a3\u7684\u6c34\u73af\u5883\u4e2d\u4e0d\u53ef\u884c\u3002<\/span><\/p>\n


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\u8fd9\u7bc7\u8bba\u6587\u7684\u9879\u76ee\u8d1f\u8d23\u4eba\u3001\u6155\u5c3c\u9ed1\u5927\u5b66\u6709\u673a\u5316\u5b66\u7cfb\u4e3b\u4efbThomas Carell\u8bf4\uff1a\u4f46\u5927\u591a\u6570\u4eba\u90fd\u4e13\u6ce8\u4e8e\u4ee5\u66f4\u7b80\u5355\u7684\u5f62\u5f0f\u91cd\u65b0\u521b\u9020\u719f\u6089\u7684\u86cb\u767d\u8d28\u7ffb\u8bd1\u8fc7\u7a0b\u3002\u5982\u679c\u53e4\u8001\u7684\u7ffb\u8bd1\u8fc7\u7a0b\u770b\u8d77\u6765\u4e0e\u73b0\u4ee3\u7684\u5f62\u5f0f\u5927\u4e0d\u76f8\u540c\u5462\uff1f<\/span><\/p>\n


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Carell\u548c\u4ed6\u7684\u56e2\u961f\u5f00\u59cb\u6df1\u5165\u7814\u7a76\u8fd9\u4e2a\u60f3\u6cd5\uff0c\u5bfb\u627e\u53ef\u80fd\u5b58\u5728\u4e8e\u539f\u59cb\u6761\u4ef6\u4e0b\u66f4\u5f3a\u7684\u952e\u3002\u5c31\u8fd9\u6837\uff0c\u4ed6\u4eec\u5c06\u6ce8\u610f\u529b\u653e\u5728\u4e86\u5e38\u88ab\u5ffd\u89c6\u7684\u975e\u5178\u578b\u6838\u82f7\u9178\u5206\u5b50<\/strong><\/span>\uff08noncanonical nucleotides\uff09<\/span>\u4e0a\u3002RNA\u7684\u9057\u4f20\u5bc6\u7801\u901a\u5e38\u7531\u56db\u79cd\u78b1\u57fa<\/span>\uff08\u817a\u560c\u5464\u3001\u9e1f\u560c\u5464\u3001\u80de\u5627\u5576\u548c\u5c3f\u5627\u5576\uff09<\/span>\u7ec4\u6210\uff0c\u4f46\u5e26\u6709\u5176\u4ed6\u78b1\u57fa\u7684\u6838\u82f7\u9178\u4e5f\u5b58\u5728\u4e8e\u8bb8\u591aRNA\u5206\u5b50\u4e2d\uff0c\u5b83\u4eec\u6709\u5176\u5b83\u7684\u4f5c\u7528\uff0c\u5305\u62ec\u5e2e\u52a9\u6838\u7cd6\u4f53\u4ea7\u751f\u86cb\u767d\u8d28\u3002\u8fd9\u4e9b\u975e\u5178\u578b\u6838\u82f7\u9178\u53ef\u4ee5\u4e0e\u6c28\u57fa\u9178\u7ed3\u5408\uff0c\u5176\u5316\u5b66\u952e\u6bd4\u6c28\u57fa\u9178\u4e0etRNA\u5206\u5b50\u7ed3\u5408\u7684\u5316\u5b66\u952e\u8981\u5f3a\u5f97\u591a\u3002<\/span><\/p>\n


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\u56fe2. \u5efa\u9020\u591a\u80bd\u94fe\u7684\u65b0\u65b9\u5f0f\u3002\u5982\u4eca\u6240\u6709\u7684\u751f\u547d\u4f7f\u7528\u6838\u7cd6\u4f53\u6765\u751f\u4ea7\u591a\u80bd\uff08\u5de6\u56fe\uff09\uff0c\u4f46\u8fdc\u53e4\u65f6\u4ee3\uff0c\u5355\u72ec\u7684RNA\u6216\u8bb8\u53ef\u4ee5\u4ee5\u4e00\u79cd\u65b0\u65b9\u5f0f\u751f\u4ea7\u591a\u80bd\uff08\u53f3\u56fe\uff09\u3002<\/span><\/section>\n


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\u57282018\u5e74\u7684\u4e00\u9879\u7814\u7a76\u4e2d\uff0cCarell\u548c\u56e2\u961f\u62a5\u544a\u8bf4\uff0c\u5728\u751f\u547d\u8bde\u751f\u4e4b\u524d\uff0c\u5178\u578b\u6838\u82f7\u9178\u548c\u975e\u5178\u578b\u6838\u82f7\u9178\u53ef\u80fd\u662f\u540c\u65f6\u6f14\u5316\u3002\u5176\u4e2d\u4e00\u4e9b\u5728tRNA\u548c\u6838\u7cd6\u4f53RNA\u4e2d\u7684\u6838\u82f7\u9178\u5b58\u5728\u4e8e\u6240\u6709\u751f\u7269\u6700\u540e\u666e\u904d\u7684\u5171\u540c\u7956\u5148<\/span>\uff08LUCA\uff09<\/span>\u4e2d\u3002<\/span><\/p>\n


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\u8bba\u6587\u9898\u76ee\uff1a<\/span><\/p>\n

Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth-Generation by Prebiotic Methylations and Carbamoylations<\/span><\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1a<\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/29533524\/<\/span><\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n


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Carell\u8bf4\uff1a\u201c\u5728\u8fd9\u4e2a\u7cfb\u7edf\u6700\u53e4\u8001\u7684\u90e8\u5206\uff0c\u53e4\u8001\u7684RNA\u4e16\u754c\u7684\u9057\u8ff9\u5f7c\u6b64\u76f8\u90bb\u3002\u6240\u4ee5\u6211\u4eec\u8bf4\uff0c\u597d\u5427\uff0c\u8fd9\u4e9b\u662f\u6211\u4eec\u7684\u5316\u77f3\u2014\u2014\u8ba9\u6211\u4eec\u770b\u770b\u8fd9\u4e9b\u5316\u77f3\u80fd\u544a\u8bc9\u6211\u4eec\u4ec0\u4e48\u3002\u201d<\/span><\/p>\n


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\u4ed6\u4eec\u5f00\u53d1\u4e86\u4e00\u79cd\u4e0d\u540c\u7684\u591a\u80bd\u751f\u957f\u6a21\u578b\uff0c\u8bbe\u60f3\u4e24\u6761\u7531\u975e\u5178\u578b\u6838\u82f7\u9178\u6240\u8986\u76d6\u7684RNA\u94fe\uff0c\u5176\u4e2d\u4e00\u6761\u901a\u8fc7\u66f4\u5f3a\u7684\u952e\u5c06\u6c28\u57fa\u9178\u88c5\u5165\u5176\u4e2d\u3002\u5728\u83b7\u53d6\u8df3\u5230\u7b2c\u4e8c\u6761\u94fe\u4e0a\u7684\u6c28\u57fa\u9178\u540e\uff0c\u4ed6\u4eec\u53ef\u4ee5\u5728\u7b2c\u4e00\u4e2a\u94fe\u4e0a\u91cd\u65b0\u88c5\u8f7d\u53e6\u4e00\u4e2a\u6c28\u57fa\u9178\u3002\u901a\u8fc7\u5bf9\u7cfb\u7edf\u8fdb\u884c\u5faa\u73af\u52a0\u70ed\u548c\u51b7\u5374\uff0c\u53ef\u4ee5\u5728\u4e24\u6761\u94fe\u4e0a\u7684\u6c28\u57fa\u9178\u4e4b\u95f4\u53cd\u590d\u65ad\u88c2\u548c\u5f62\u6210\u952e\uff0c\u5c06\u6c28\u57fa\u9178\u4ece\u4e00\u6761\u94fe\u7ffb\u8f6c\u5230\u53e6\u4e00\u6761\u94fe\u4e0a\uff0c\u4f7f\u94fe\u5ef6\u957f\u3002<\/span><\/p>\n


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\u5b9e\u9645\u4e0a\uff0c\u5982\u679c\u6784\u5efa\u591a\u80bd\u5c31\u50cf\u7528\u79ef\u6728\u7ec4\u88c5\u5854\u7684\u8bdd\uff0c\u65b0\u7684\u8fc7\u7a0b\u5c31\u662f\u5728\u4e0d\u65ad\u589e\u9ad8\u7684\u5854\u9876\u6dfb\u52a0\u79ef\u6728\u6765\u589e\u52a0\u6c28\u57fa\u9178\uff0c\u800c\u6838\u7cd6\u4f53\u86cb\u767d\u8d28\u7684\u5408\u6210\u5219\u50cf\u662f\u901a\u8fc7\u79fb\u52a8\u5854\u5230\u5e95\u90e8\u7684\u65b0\u5757\u4e0a\u6765\u589e\u9ad8\u8fd9\u4e2a\u5854\u3002<\/span><\/p>\n


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\u9a8c\u8bc1\u4ed6\u4eec\u7684\u7406\u8bba\u9700\u8981\u4e00\u7cfb\u5217\u88ab Carell \u79f0\u4e3a\u201c\u4e4f\u5473\u201d\u548c\u201c\u6b8b\u9177\u7684\u6770\u4f5c\u201d\u7684\u5b9e\u9a8c\u2014\u2014\u4f46\u6700\u7ec8\uff0c\u4ed6\u4eec\u8bc1\u660e\u4e86\u8fd9\u4e00\u8fc7\u7a0b\u786e\u5b9e\u53ef\u4ee5\u4ea7\u751f\u957f\u8fbe13\u4e2a\u6c28\u57fa\u9178\u7684\u591a\u80bd\u3002<\/span><\/p>\n


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\u8fd9\u4e00\u8fc7\u7a0b\u4e0e\u7ec6\u80de\u4e2d\u7684\u86cb\u767d\u8d28\u8f6c\u8bd1\u76f8\u5dee\u751a\u8fdc\u3002\u6700\u91cd\u8981\u7684\u7f3a\u5931\u7279\u5f81\u662f\uff1a\u6838\u7cd6\u4f53\u7ffb\u8bd1mRNA\u4e2d\u7f16\u7801\u7279\u5b9a\u86cb\u767d\u8d28\u7684\u6307\u4ee4\u3002\u5728\u65b0\u7cfb\u7edf\u4e2d\uff0c\u201c\u6211\u4eec\u57f9\u517b\u4e86\u76f8\u5bf9\u968f\u673a\u7684\u591a\u80bd\u3002\u201dCarell\u8bf4\u3002<\/span><\/p>\n


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\u4f46\u7814\u7a76\u4eba\u5458\u786e\u5b9e\u6210\u529f\u5730\u8bc1\u660e\u4e86\u591a\u80bd\u5b8c\u5168\u53ef\u4ee5\u7531RNA\u9010\u6b65\u5408\u6210\uff0c\u8fd9\u662f\u201c\u4ee5\u524d\u6ca1\u6709\u505a\u8fc7\u7684\u4e8b\u60c5\u201d\uff0cBonfio\u8bf4\u3002\u603b\u800c\u8a00\u4e4b\uff0c\u8fd9\u4e2a\u88ab\u8bc1\u660e\u7684\u8fc7\u7a0b\u662f\u8fc8\u5411\u5206\u5b50\u8bc6\u522b\u7684\u91cd\u8981\u4e00\u6b65\uff0c\u5c3d\u7ba1\u5b83\u4e0d\u662f\u6838\u7cd6\u4f53\u7684\u539f\u59cb\u7248\u672c\u3002<\/span><\/p>\n


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\u201c\u4ece\u5316\u5b66\u7684\u89d2\u5ea6\u6765\u8bf4\uff0c\u8fd9\u662f\u4e00\u4e2a\u975e\u5e38\u7f8e\u4e3d\u7684\u4f8b\u5b50\uff0c\u201d\u6ca1\u6709\u53c2\u4e0e\u8fd9\u9879\u7814\u7a76\u7684\u4e9a\u5229\u6851\u90a3\u5dde\u7acb\u5927\u5b66\u526f\u6559\u6388 Sara Walker \u8bf4\u3002\u4f46\u662f\u540c\u65f6\uff0c\u5979\u548c\u683c\u62c9\u65af\u54e5\u5927\u5b66\u5316\u5b66\u7cfb\u4e3b\u5e2d Lee Cronin \u4e5f\u90fd\u8ba4\u4e3a\uff0c\u8fd9\u4e2a\u7cfb\u7edf\u53ef\u80fd\u8fc7\u4e8e\u4eba\u4e3a\u8bbe\u8ba1\uff0c\u6216\u8005\u592a\u4e0d\u73b0\u5b9e\uff0c\u65e0\u6cd5\u6a21\u62df\u751f\u547d\u5f00\u59cb\u65f6\u53ef\u80fd\u53d1\u751f\u7684\u60c5\u51b5\u3002<\/span><\/p>\n


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\u7136\u800c\uff0c\u5bf9\u5176\u4ed6\u4eba\u6765\u8bf4\uff0c\u8fd9\u7bc7\u5de5\u4f5c\u5bf9\u539f\u59cb\u4e16\u754c\u7684\u6a21\u62df\u5e76\u4e0d\u91cd\u8981\uff0c\u91cd\u8981\u7684\u662f\u5b83\u4e3a\u8fdb\u4e00\u6b65\u7814\u7a76\u6253\u5f00\u4e86\u5927\u95e8\u3002\u4fc4\u4ea5\u4fc4\u5dde\u5168\u56fd\u513f\u7ae5\u533b\u9662\u57fa\u56e0\u6cbb\u7597\u4e2d\u5fc3<\/span>\uff08Nationwide Children\u2019s Hospital\u2019s Center for Gene Therapy\uff09<\/span>\u7684\u7814\u7a76\u52a9\u7406\u6559\u6388Nizar Saad\u8bf4\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u591a\u80bd\u548cRNA\u53ef\u4ee5\u4e00\u8d77\u6f14\u5316\u3002\u5f88\u660e\u663e\uff0c\u8fd9\u53ef\u4ee5\u901a\u8fc7\u5b9e\u9a8c\u548c\u5316\u5b66\u65b9\u6cd5\u5b9e\u73b0\u3002RNA-\u591a\u80bd\u4e16\u754c\u201c\u662f\u79d1\u5b66\u754c\u73b0\u5728\u7684\u7814\u7a76\u65b9\u5411\u201d\u3002<\/span><\/p>\n


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4. RNA-\u591a\u80bd\u4e16\u754c<\/span><\/strong><\/strong><\/p>\n<\/section>\n

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\u201c\u6211\u4e0d\u60f3\u53d6\u4ee3RNA\u4e16\u754c\u7406\u8bba\uff0c\u201dCarell\u8bf4\u3002\u201c\u4f46\u6211\u8ba4\u4e3a\u6211\u4eec\u9700\u8981\u6269\u5c55\u5b83\uff0c\u8ba9\u5b83\u66f4\u53ef\u4fe1\u3002\u201d\u4ed6\u8ba4\u4e3aRNA\u548c\u591a\u80bd\u4e0d\u662f\u5355\u72ec\u6f14\u5316\u5404\u81ea\u7684\u590d\u6742\u6027\uff0c\u800c\u662f\u4f5c\u4e3a\u4e00\u4e2a\u5355\u4e00\u5206\u5b50\u4e00\u8d77\u6f14\u5316\uff0c\u76f8\u4e92\u8865\u5145\u529f\u80fd\u3002<\/span><\/p>\n


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Carell\u8bf4\uff0cRNA\u548c\u591a\u80bd\u5171\u540c\u6f14\u5316\u7684\u5d4c\u5408\u4f53\u5c06\u4e3a\u751f\u547d\u6f14\u5316\u63d0\u4f9b\u6700\u597d\u7684\u8bbe\u60f3\u3002\u4ed6\u548c\u4ed6\u7684\u56e2\u961f\u53d1\u73b0\uff0c\u4e0d\u4ec5RNA\u5206\u5b50\u6709\u52a9\u4e8e\u591a\u80bd\u7684\u751f\u957f\uff0c\u800c\u4e14\u591a\u80bd\u7ed9RNA\u5206\u5b50\u5e26\u6765\u4e86\u7a33\u5b9a\u6027<\/strong>\u3002<\/span><\/p>\n


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\u968f\u7740\u5d4c\u5408\u4f53\u7684\u7ed3\u6784\u53d8\u5f97\u66f4\u957f\u3001\u66f4\u590d\u6742\uff0c\u591a\u80bd\u90e8\u5206\u53ef\u80fd\u5df2\u7ecf\u8db3\u591f\u7a33\u5b9aRNA\uff0c\u4f7f\u5176\u5f00\u59cb\u81ea\u6211\u590d\u5236\u548c\u6f14\u5316\u3002\u4e0e\u6b64\u540c\u65f6\uff0cRNA\u4e5f\u53ef\u80fd\u5df2\u7ecf\u8ba9\u591a\u80bd\u90e8\u5206\u83b7\u5f97\u4e86\u8db3\u591f\u590d\u6742\u7684\u7ed3\u6784\uff0c\u4ece\u800c\u5f00\u59cb\u50ac\u5316\u53cd\u5e94\u3002\u6700\u7ec8\uff0c\u8fd9\u4e9b\u90e8\u5206\u53ef\u80fd\u4f1a\u5206\u88c2\uff0c\u5e76\u5f00\u59cb\u4ee5\u66f4\u63a5\u8fd1\u6838\u7cd6\u4f53\u7684\u65b9\u5f0f\u76f8\u4e92\u4f5c\u7528\u3002<\/span><\/p>\n


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Carell\u548c\u4ed6\u7684\u56e2\u961f\u63a5\u4e0b\u6765\u5e0c\u671b\u4e86\u89e3\uff0c\u662f\u5426\u80fd\u8ba9\u975e\u5178\u578bRNA\u5206\u5b50\u4ece\u7f16\u7801\u4fe1\u606f\u4e2d\u751f\u6210\u7279\u5b9a\u7684\u591a\u80bd\u3002\u7136\u540e\uff0c\u4ed6\u4eec\u5e0c\u671b\u770b\u5230\u8fd9\u79cd\u591a\u80bd\u662f\u5426\u80fd\u53d1\u6325\u50ac\u5316\u529f\u80fd\uff0c\u4ece\u800c\u5e2e\u52a9RNA\u590d\u5236\u3002<\/span><\/p>\n


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\u65e0\u8bba\u672a\u6765\u7684\u6210\u529f\u6216\u5931\u8d25\uff0c\u6211\u4eec\u603b\u662f\u5f88\u96be\u786e\u5207\u5730\u77e5\u9053\u6570\u5341\u4ebf\u5e74\u524d\u53d1\u751f\u4e86\u4ec0\u4e48\u3002Carell \u8bf4\uff1a\u201c\u6211\u4eec\u65e0\u6cd5\u56de\u5230\u8fc7\u53bb\uff0c\u6240\u4ee5\u65e0\u8bba\u4f60\u5728\u8fd9\u4e2a\u9886\u57df\u6784\u5efa\u4ec0\u4e48\uff0c\u603b\u6709\u4eba\u4f1a\u6307\u70b9\uff1a\u2019\u6211\u8ba4\u4e3a\u4e8b\u60c5\u662f\u5b8c\u5168\u4e0d\u4e00\u6837\u2019\u3002\u5982\u679c\u6709\u4eba\u63d0\u51fa\u4e86\u4e00\u4e2a\u66f4\u597d\u7684\u6a21\u578b\uff0c\u6211\u4eec\u5c06\u975e\u5e38\u6b22\u8fce\u3002\u8fd9\u5c31\u662f\u79d1\u5b66\u53d1\u5c55\u5e94\u6709\u7684\u6837\u5b50\u3002\u201d<\/span><\/p>\n


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\u672c\u6587\u7ffb\u8bd1\u81ea QuantaMagazine.<\/span><\/p>\n

\u539f\u6587\u9898\u76ee\uff1aLife\u2019s First Peptides May Have Grown on RNA Strands<\/span><\/p>\n

\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/www.quantamagazine.org\/lifes-first-peptides-may-have-grown-on-rna-20220524\/<\/span><\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n


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\u81ea\u751f\u6210\u7ed3\u6784\u8bfb\u4e66\u4f1a\u62a5\u540d\u4e2d<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u751f\u547d\u662f\u6709\u5fc3\uff08\u610f\u8bc6\uff09\u7684\uff0c\u4f46\u5f53\u4f60\u4e00\u5c42\u5c42\u5265\u5f00\u751f\u547d\u7684\u7ec4\u7ec7\uff0c\u5374\u53ea\u6709\u5fc3\u810f\u800c\u6ca1\u6709\u4e00\u9897\u201c\u5fc3\u7075\u201d\uff1b\u6253\u5f00\u5927\u8111\u76ae\u5c42\u770b\u5230\u4e00\u4e2a\u4e2a\u795e\u7ecf\u5143\uff0c\u5374\u770b\u4e0d\u5230\u201c\u610f\u8bc6\u201d\u3002\u7136\u800c\uff0c\u751f\u547d\u4e0e\u610f\u8bc6\u90fd\u5177\u6709\u201c\u81ea\u6211\u751f\u6210\u201c\u7684\u80fd\u529b\uff0c\u751f\u547d\u81ea\u53d1\u4ece\u975e\u751f\u547d\u4e2d\u751f\u6210\uff0c\u610f\u8bc6\u81ea\u53d1\u4ece\u751f\u547d\u4e2d\u751f\u6210\u3002\u66f4\u60ca\u4eba\u7684\u662f\uff0c\u751f\u547d\u4e0e\u610f\u8bc6\u7684\u81ea\u6211\u751f\u6210\u7ed3\u6784\u4f3c\u4e4e\u5f88\u76f8\u4f3c\u3002\u5982\u679c\u8fd9\u4e2a\u5047\u8bbe\u6210\u7acb\uff0c\u90a3\u4e48\u6700\u53ef\u80fd\u7684\u5907\u9009\u7ed3\u6784\u4f1a\u662f\u4ec0\u4e48\u5462\uff1f<\/span><\/p>\n


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\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/section>\n
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\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n