{"id":36259,"date":"2022-08-02T21:58:15","date_gmt":"2022-08-02T13:58:15","guid":{"rendered":"https:\/\/swarma.org\/?p=36259"},"modified":"2022-08-02T21:58:15","modified_gmt":"2022-08-02T13:58:15","slug":"%e9%87%8f%e5%8c%96%e7%bb%86%e8%83%9e%e5%86%85%e7%9a%84%e4%bf%a1%e6%81%af%e6%b5%81%ef%bc%9a%e6%9c%ba%e5%99%a8%e5%ad%a6%e4%b9%a0%e6%97%b6%e4%bb%a3%e4%b8%8b%e7%9a%84%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=36259","title":{"rendered":"\u91cf\u5316\u7ec6\u80de\u5185\u7684\u4fe1\u606f\u6d41\uff1a\u673a\u5668\u5b66\u4e60\u65f6\u4ee3\u4e0b\u7684\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"
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\u7814\u7a76\u7ec6\u80de\u5185\u4fe1\u53f7\u5206\u5b50\u4f20\u9012\u4fe1\u606f\u7684\u80fd\u529b\u662f\u7406\u89e3\u751f\u547d\u7cfb\u7edf\u7684\u57fa\u672c\u95ee\u9898\u4e4b\u4e00\u3002<\/span>2022\u5e747\u670812\u65e5\uff0c\u6765\u81ea\u5317\u4eac\u5e08\u8303\u5927\u5b66\u73e0\u6d77\u6821\u533a\u548c<\/span>\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u7684\u5b66\u8005\u5728\u6700\u65b0\u7684\u7efc\u8ff0\u201cQuantifying information of intracellular signaling: progress with machine learning\u201d\u4e2d\uff0c\u56de\u987e\u4e86\u5982\u4f55\u4f7f\u7528\u4fe1\u606f\u8bba\u65b9\u6cd5\uff0c\u6765\u91cf\u5316\u7ec6\u80de\u5185\u5206\u5b50\u7684\u4fe1\u606f\u4f20\u9012\u3002<\/span>\u7279\u522b\u5730\uff0c\u6587\u4e2d\u603b\u7ed3\u548c\u6bd4\u8f83\u4e86\u5229\u7528\u673a\u5668\u5b66\u4e60\u7684\u65b9\u6cd5\u6765\u5904\u7406\u5206\u5b50\u4fe1\u53f7\u7684\u590d\u6742\u65f6\u95f4\u8f68\u8ff9\u7684\u6700\u65b0\u7814\u7a76\uff0c\u8fd9\u4e9b\u7814\u7a76\u5e2e\u52a9\u63ed\u793a\u4e86\u7ec6\u80de\u5982\u4f55\u5229\u7528\u65f6\u95f4\u7f16\u7801\u7684\u4fe1\u606f\u6765\u9002\u5e94\u73af\u5883\u53d8\u5316\u3002<\/span><\/span><\/p>\n


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\u7814\u7a76\u9886\u57df\uff1a\u673a\u5668\u5b66\u4e60\uff0c\u7ec6\u80de\u5185\u4fe1\u53f7\uff0c\u4fe1\u606f\u8bba<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u6c64\u8fce<\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong> <\/span>| \u5ba1\u6821<\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/p>\n

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\u4e3a\u4e86\u66f4\u597d\u7684\u53d9\u8ff0\u5982\u4f55\u91cf\u5316\u7ec6\u80de\u5185\u5206\u5b50\u7684\u4fe1\u606f\u4f20\u9012\uff0c\u6587\u4e2d\u4ecb\u7ecd\u4e09\u7c7b\u5e38\u7528\u7684\u4fe1\u606f\u5ea6\u91cf\u65b9\u6cd5\uff1a\u7ecf\u5178\u4fe1\u606f\u8bba\u4e2d\u7684\u4fe1\u606f\u5ea6\u91cf\u3001\u65f6\u95f4\u70b9\u5c3a\u5ea6\u4e0a\u4ee5\u53ca\u65f6\u95f4\u5e8f\u5217\u8f68\u8ff9\u5c3a\u5ea6\u4e0a\u7684\u4fe1\u606f\u5ea6\u91cf\u3002<\/span><\/p>\n


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1. \u7ecf\u5178\u4fe1\u606f\u8bba\u4e2d\u7684\u4fe1\u606f\u5ea6\u91cf<\/span><\/strong><\/span><\/p>\n


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\u56fe1\uff1a\u7ecf\u5178\u4fe1\u606f\u8bba\u4e2d\u7684\u4fe1\u606f\u5ea6\u91cf\u65b9\u6cd5\u603b\u7ed3\uff0c\u8be6\u7ec6\u5185\u5bb9\u53ca\u53c2\u8003\u6587\u732e\u53ef\u67e5\u9605\u539f\u6587<\/span><\/section>\n


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\u9999\u519c\u71b5<\/span><\/strong>\uff08Shannon entropy\uff09<\/span>\u4e0e\u7edf\u8ba1\u7269\u7406\u5bc6\u5207\u76f8\u5173\uff0c\u5bf9\u4e8e\u7ed9\u5b9a\u6570\u636e\u7684\u6a21\u578b\u63a8\u65ad\uff0c\u71b5\u63d0\u4f9b\u4e86\u4e00\u79cd\u53ef\u4f18\u5316\u7684\u4f3c\u7136\uff0c\u4f8b\u5982\u5b9a\u91cf\u751f\u7269\u5b66\u4e2d\u57fa\u56e0\u7ec4\u5e8f\u5217\u7684\u86cb\u767d\u8d28\u4e09\u7ef4\u7ed3\u6784\u7684\u63a8\u65ad\u7b49\u3002\u5f53\u6982\u7387\u5206\u5e03\u8fde\u7eed\u65f6\uff0c\u9999\u519c\u71b5\u53ef\u4ee5\u4f5c\u4e3a\u5fae\u5206\u71b5<\/span>\uff08Differential entropy\uff09<\/span>\uff0c\u5fae\u5206\u71b5\u7684\u4f30\u8ba1\u4f9d\u8d56\u4e8e\u5bf9\u6982\u7387\u5206\u5e03\u7684\u4f30\u8ba1\u3002\u6211\u4eec\u5e38\u7528\u6709\u9650\u6837\u672c\u7684\u9891\u7387\u4f5c\u4e3a\u6982\u7387\u7684\u4f30\u8ba1\u6765\u8ba1\u7b97\u6982\u7387\u5206\u5e03\u7684\u71b5\u3002\u5f53\u7ed9\u5b9aN\u4e2a\u6837\u672c\u65f6\uff0c\u5fae\u5206\u71b5\u5e38\u5199\u4f5c\uff1a<\/sub><\/span>\uff0c<\/sub>\u662f\u7b2cj\u4e2a\u4e8b\u4ef6\u7684\u9891\u7387\u503c\uff0c\u5f53\u91c7\u6837\u6570\u636e\u8db3\u4ee5\u8986\u76d6\u5168\u6982\u7387\u5206\u5e03\u7684\u9891\u7387\u6784\u578b\u65f6\uff0c\u6837\u672c\u7684\u5e73\u5747\u71b5\u8fd1\u4f3c\u4e8e\u5168\u6982\u7387\u5206\u5e03\u7684\u71b5\u3002<\/span><\/p>\n


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KL\u6563\u5ea6<\/span><\/strong>\uff08Kullback\u2013Leibler (KL)-divergence\uff09<\/span>\u5e38\u7528\u6765\u8861\u91cf\u4e24\u4e2a\u5206\u5e03\u4e4b\u95f4\u7684\u4e0d\u76f8\u4f3c\u5ea6\uff0c\u540c\u65f6\u5b83\u8fd8\u6709\u4e00\u4e2a\u540d\u5b57\u53eb\u76f8\u5bf9\u71b5<\/span>\uff08relative entropy\uff09<\/span>\u53ef\u4ee5\u7406\u89e3\u4e3a\u4e24\u4e2a\u5206\u5e03\u7684\u4ea4\u53c9\u71b5\u548c\u4e00\u4e2a\u5206\u5e03\u7684\u9999\u519c\u71b5\u4e4b\u5dee\uff0c\u5177\u4f53\u8ba1\u7b97\u516c\u5f0f\u53ef\u89c1\u56fe1\u3002\u4ea4\u53c9\u71b5<\/span>\uff08Cross entropy.\uff09<\/span>\u5e38\u4f5c\u4e3a\u673a\u5668\u5b66\u4e60\u4e2d\u7684\u4f18\u5316\u51fd\u6570\uff0c\u901a\u8fc7\u6700\u5c0f\u5316\u6a21\u578b\u62df\u5408\u5206\u5e03\u548c\u5b9e\u9645\u6570\u636e\u5206\u5e03\u4e4b\u95f4\u7684\u4ea4\u53c9\u71b5\u6765\u8bad\u7ec3\u6a21\u578b\u53c2\u6570\uff0c\u4ea4\u53c9\u71b5\u662fKL\u6563\u5ea6\u548c\u9999\u519c\u71b5\u4e4b\u548c\uff0c\u53ef\u4ee5\u8868\u793a\u4e3a\uff1a<\/sub><\/span>\u3002<\/span><\/p>\n


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\u4e92\u4fe1\u606f<\/span><\/strong>\uff08Mutual information\uff09<\/span>\u6709\u5bf9\u79f0\u7684\u6027\u8d28\uff0c\u6240\u4ee5\u5b83\u91cf\u5316\u7684\u662f\u53d8\u91cf\u95f4\u7684\u76f8\u4e92\u4f9d\u8d56\u5173\u7cfb\uff0c\u5373\u4e00\u4e2a\u968f\u673a\u53d8\u91cf\u901a\u8fc7\u89c2\u5bdf\u53e6\u4e00\u4e2a\u968f\u673a\u53d8\u91cf\u6240\u83b7\u5f97\u7684\u4fe1\u606f\u91cf\u3002\u5728\u5b9e\u8df5\u4e2d\uff0c\u4eba\u4eec\u901a\u5e38\u5173\u5fc3\u6700\u5927\u4e92\u4fe1\u606f<\/span>\uff08\u901a\u9053\u5bb9\u91cf\uff09<\/span>\uff0c\u5e76\u4e14\u53ea\u5bf9\u4e00\u4e2a\u53d8\u91cf\u8fdb\u884c\u6700\u5927\u5316\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u4e92\u4fe1\u606f\u4e5f\u53ef\u4ee5\u770b\u505a\u968f\u673a\u53d8\u91cf\u7684\u5148\u9a8c\u6982\u7387\u5206\u5e03\u548c\u6761\u4ef6\u6982\u7387\u5206\u5e03\u4e4b\u95f4\u7684KL\u6563\u5ea6\uff0c\u5373\u4e00\u4e2a\u968f\u673a\u53d8\u91cf\u7531\u4e8e\u5df2\u77e5\u53e6\u4e00\u4e2a\u968f\u673a\u53d8\u91cf\u800c\u51cf\u5c11\u7684\u4e0d\u786e\u5b9a\u6027\uff0c\u5199\u4f5c\uff1a<\/sub><\/span>\uff0c\u5373\u4e92\u4fe1\u606f\u662f\u5728\u4e00\u4e2a\u53d8\u91cfY\u7684\u5206\u5e03\u4e0b\uff0c\u5355\u53d8\u91cfX\u7684\u5206\u5e03\u548cX\uff0cY\u6761\u4ef6\u5206\u5e03\u7684KL\u6563\u5ea6\u7684\u671f\u671b\u3002<\/span><\/p>\n


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2. \u65f6\u95f4\u70b9\u5c3a\u5ea6\u4e0a\u7684\u4fe1\u606f\u5ea6\u91cf<\/span><\/strong><\/span><\/p>\n


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\u6b63\u5982\u4e0a\u8ff0\u6240\u63d0\u5230\uff0c\u4e92\u4fe1\u606f\u662f\u5177\u6709\u5bf9\u79f0\u6027\u7684\uff0c\u91cf\u5316\u7684\u662f\u53d8\u91cf\u95f4\u7684\u76f8\u4e92\u4f9d\u8d56\u5173\u7cfb\uff0c\u800c\u5728\u5b9e\u9645\u573a\u666f\u4e0b\uff0c\u7ec6\u80de\u5f80\u5f80\u662f\u88ab\u52a8\u7684\u63a5\u53d7\u5916\u754c\u73af\u5883\u7684\u523a\u6fc0\uff0c\u8fd9\u79cd\u5173\u7cfb\u662f\u6709\u65b9\u5411\u6027\u7684<\/strong>\uff0c\u6240\u4ee5\u5f53\u6211\u4eec\u53bb\u63a2\u7a76\u5982\u9a71\u52a8-\u54cd\u5e94\u5173\u7cfb\u3001\u56e0\u679c\u5173\u7cfb\u65f6\uff0c\u4e0a\u8ff0\u65b9\u6cd5\u4e0d\u9002\u7528\u3002\u800c\u65f6\u95f4\u70b9\u5c3a\u5ea6\u4e0a\u7684\u8f6c\u79fb\u71b5\uff0c\u65f6\u95f4\u5e8f\u5217\u8f68\u8ff9\u5c3a\u5ea6\u4e0a\u7684\u8f68\u8ff9\u71b5\u5219\u662f\u6211\u4eec\u63a2\u7a76\u65b9\u5411\u6027\u5173\u7cfb\u7684\u6865\u6881\u3002<\/span><\/p>\n


<\/p>\n

\u8f6c\u79fb\u71b5<\/span><\/strong>\uff08Transfer entropy\uff09<\/span>\u5728\u7ed9\u5b9a\u8f6c\u79fb\u6982\u7387\u7684\u60c5\u51b5\u4e0b\uff0c\u5ea6\u91cf\u4e24\u4e2a\u65f6\u95f4\u5e8f\u5217\u4e4b\u95f4\u6709\u5411\u4f20\u9012\u7684\u4fe1\u606f\u7684\u91cf\uff0c\u53ef\u4ee5\u7528\u6765\u533a\u5206\u9a71\u52a8\u8981\u7d20\u548c\u54cd\u5e94\u8981\u7d20\u3002\u5176\u5b9a\u4e49\u5982\u4e0b\uff1a<\/sub><\/span>\uff0c\u8f6c\u79fb\u71b5\u5728\u516c\u5f0f\u4e0a\u5f62\u5982\u4e92\u4fe1\u606f\uff0c\u53ef\u7406\u89e3\u4e3a\u6761\u4ef6\u71b5\u7684\u5dee\u503c\uff0c\u800c\u53ea\u8003\u8651\u4e0a\u4e00\u65f6\u95f4\u70b9\u7684\u503c\u4f5c\u4e3a\u6761\u4ef6\u662f\u7cfb\u7edf\u9a6c\u5c14\u53ef\u592b\u6027\u7684\u4f53\u73b0\u3002\u5f53\u63a2\u7a76\u4e24\u4e2a\u65f6\u95f4\u5e8f\u5217\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u65f6\uff0c\u6211\u4eec\u5e38\u7528\u4e00\u4e2a\u6982\u7387\u5206\u5e03<\/sub>\u6765\u903c\u8fd1\u8054\u5408\u6982\u7387\u5206\u5e03<\/sub>\uff0c\u4e24\u4e2a\u65f6\u95f4\u5e8f\u5217\u5355\u65f6\u95f4\u70b9\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u53ef\u4ee5\u7528\u6700\u5c0f\u5316\u8fd9\u4e24\u4e2a\u5206\u5e03\u4e4b\u95f4\u7684KL\u6563\u5ea6\u6765\u91cf\u5316\u6d4b\u5b9a\uff0c\u6570\u5b66\u4e0a\u5b9a\u4e49\u4e3a\uff1a<\/sub><\/span>\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4e0a\u8ff0\u65b9\u6cd5\u5728\u5355\u65f6\u95f4\u70b9\u7684\u5c3a\u5ea6\u4e0a\u5bf9\u5177\u6709\u65b9\u5411\u6027\u7684\u4fe1\u606f\u8f6c\u79fb\u8fdb\u884c\u91cf\u5316\u3002\u5728\u67d0\u4e9b\u5b9e\u9a8c\u6761\u4ef6\u4e0b\uff0c\u6211\u4eec\u53ef\u4ee5\u5f97\u5230\u957f\u65f6\u7a0b\u7684\u7ec6\u80de\u54cd\u5e94\u4fe1\u53f7\uff0c\u6b64\u65f6\u66f4\u5173\u5fc3\u5168\u5c40\u5c3a\u5ea6\u4e0b\u53d8\u91cf\u95f4\u7684\u65b9\u5411\u6027\u5173\u7cfb\uff0c\u8fd9\u65f6\u4ece\u65f6\u95f4\u5e8f\u5217\u8f68\u8ff9\u5c3a\u5ea6\u4e0a\u8003\u8651\u4fe1\u606f\u5ea6\u91cf\u5219\u662f\u66f4\u597d\u7684\u65b9\u5f0f\u3002<\/span><\/p>\n


<\/p>\n

3. \u65f6\u95f4\u5e8f\u5217\u8f68\u8ff9\u4e0a\u7684\u4fe1\u606f\u5ea6\u91cf<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u8f68\u8ff9\u71b5<\/span><\/strong>\uff08Trajectory entropy\uff09<\/span>\uff1a\u5c06\u65f6\u95f4\u5e8f\u5217\u770b\u4f5c\u4e00\u4e2a\u8f68\u8ff9\uff0c\u5219\u8be5\u8f68\u8ff9\u7684\u6982\u7387\u53ef\u4ee5\u7528\u6982\u7387\u6765\u8868\u793a\uff0c\u90a3\u4e48\u8be5\u8f68\u8ff9\u7684\u71b5\u503c\u53ef\u4ee5\u7528\u4e0b\u5f0f\u8ba1\u7b97\uff1a<\/sub><\/span>\u3002\u6bcf\u4e2a\u8f68\u8ff9\u90fd\u6709\u4e00\u4e2a\u6982\u7387\u548c\u71b5\u503c\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u8f68\u8ff9\u71b5\u7c7b\u4f3c\u4e8e\u9759\u6001\u7684\u71b5\u503c\uff0c\u53ef\u4ee5\u901a\u76f8\u540c\u7684\u65b9\u6cd5\u6765\u63a8\u65ad\uff0c\u4fe1\u606f\u7684\u6982\u5ff5\u4e5f\u53ef\u4ee5\u7528\u7c7b\u4f3c\u7684\u65b9\u6cd5\u6765\u5b9a\u4e49\u3002<\/span><\/p>\n


<\/p>\n

\u8f68\u8ff9\u7a7a\u95f4\u7684\u4e92\u4fe1\u606f<\/span><\/strong>\uff1a\u5f53\u6211\u4eec\u7684\u8f68\u8ff9\u6982\u7387\u662f\u901a\u8fc7\u52a8\u529b\u5b66\u6a21\u578b\u8ba1\u7b97\u5f97\u5230\u65f6\uff0c\u8f68\u8ff9\u71b5\u4ee5\u53ca\u4e92\u4fe1\u606f\u5c31\u53d6\u51b3\u4e8e\u6211\u4eec\u6784\u5efa\u7684\u7cfb\u7edf\u52a8\u529b\u5b66\u6a21\u578b\uff0c\u6240\u4ee5\u8574\u542b\u5728\u52a8\u529b\u5b66\u6a21\u578b\u4e2d\u7684\u5173\u4e8e\u8f68\u8ff9\u7684\u4fe1\u606f\u5c31\u53ef\u4ee5\u901a\u8fc7\u4e92\u4fe1\u606f\u5b9a\u91cf\u3002\u8003\u8651\u8f93\u5165\u8f68\u8ff9X\u548c\u8f93\u51fa\u8f68\u8ff9Y\u7684\u4e92\u4fe1\u606f\uff0c\u57fa\u672c\u601d\u8def\u5c31\u662f\u5148\u9a8c\u8f68\u8ff9\u71b5\u548c\u6761\u4ef6\u8f68\u8ff9\u71b5\u7684\u5dee\u503c\uff0c\u53ef\u4ee5\u7528\u4e0b\u5f0f\u8ba1\u7b97\uff1a<\/sub><\/span>\u3002<\/span><\/p>\n


<\/p>\n

\u5085\u91cc\u53f6\u9891\u57df\u7684\u4e92\u4fe1\u606f<\/span><\/strong>\uff1a\u7a33\u6001\u4e0b\u7684\u4e24\u4e2a\u65f6\u95f4\u5e8f\u5217\u96c6\u5408\uff0c\u6bcf\u4e2a\u96c6\u5408\u670d\u4ece\u9ad8\u65af\u7edf\u8ba1\u91cf\uff0c\u96c6\u5408\u4e4b\u95f4\u7684\u8026\u5408\u53ef\u4ee5\u7ebf\u6027\u5316\uff0c\u5728\u6b64\u5047\u8bbe\u4e0b\uff0c\u4e24\u4e2a\u5e8f\u5217\u7684\u8054\u5408\u6982\u7387\u5206\u5e03\u5728\u7a33\u6001\u5747\u503c\u9644\u8fd1\u6ce2\u52a8\u3002\u4e24\u5e8f\u5217<\/sub><\/span>\u901a\u8fc7<\/sub><\/span>\uff0c<\/sub><\/span>\u7ed9\u51fa\u3002\u534f\u65b9\u5dee\u77e9\u9635Z\u6709\u56db\u4e2a\u77e9\u9635\u5757\uff1a<\/sub><\/span>\uff0c<>\u8868\u793a\u5e73\u5747\u566a\u58f0\u6c34\u5e73\u3002\u5728\u56fa\u5b9a\u65f6\u95f4\u95f4\u9694\u7684\u8fde\u7eed\u65f6\u95f4\u6761\u4ef6\u4e0b\uff0c\u4e24\u4e2a\u8f68\u8ff9\u96c6\u5408\u4e4b\u95f4\u7684\u4e92\u4fe1\u606f\u53ef\u4ee5\u7528\u4e0b\u5f0f\u8868\u793a\uff1a<\/span><\/p>\n

<\/section>\n

<\/sub>\u662f\u5bf9\u5e94\u77e9\u9635\u5757\u7684\u529f\u7387\u8c31\u3002<\/span><\/p>\n


<\/p>\n

<\/p>\n

\u56fe2. \u5bf9\u5355\u7ec6\u80de\u54cd\u5e94\u65f6\u95f4\u5e8f\u5217\u7684\u4fe1\u606f\u91cf\u5316\u3002a.\u7528\u5355\u7ec6\u80de\u5b9e\u65f6\u6210\u50cf\u6d4b\u91cf\u4fe1\u53f7\u8ba1\u7b97\u4e92\u4fe1\u606f\u793a\u610f\u56fe\u3002b.\u5206\u522b\u4f7f\u7528\u5355\u65f6\u95f4\u70b9\u6570\u636e\u3001\u591a\u65f6\u95f4\u70b9\u548c\u957f\u65f6\u95f4\u5e8f\u5217\u7684\u65b9\u6cd5\u793a\u610f\u56fe[49]\u3002<\/span><\/section>\n


<\/p>\n


<\/p>\n

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<\/section>\n

<\/section>\n
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<\/svg><\/section>\n<\/section>\n<\/section>\n
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\u4e8c\u3001\u6570\u636e\u9a71\u52a8\u4e0b\u7ec6\u80de\u5185\u4fe1\u606f\u4f20\u9012\u7684\u91cf\u5316<\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n

<\/span><\/p>\n

\u4f5c\u8005\u5728\u6587\u4e2d\u5411\u6211\u4eec\u4ecb\u7ecd\u4e86\u4e09\u79cd\u5e38\u7528\u7684\u5355\u7ec6\u80de\u5c3a\u5ea6\u4e0b\u7684\u4fe1\u53f7\uff1a<\/span><\/p>\n


<\/p>\n

1.\u5355\u7ec6\u80deRNA\u5e8f\u5217<\/span>\uff08Single-cell RNA sequencing (scRNA-seq) \uff09<\/span>\u3002scRNA-seq\u751f\u6210\u6240\u6709\u8f6c\u5f55\u672c\u7684\u5e8f\u5217\u5256\u9762\u53ca\u5176\u5728\u5355\u7ec6\u80de\u4e2d\u7684\u76f8\u5bf9\u4e30\u5ea6\u3002\u4f46\u8be5\u79cd\u5e8f\u5217\u7531\u4e8e\u4e0d\u53ef\u5ffd\u7565\u7684\u566a\u58f0\u5f71\u54cd\u4ee5\u53ca\u6570\u636e\u7684\u7a00\u758f\u6027<\/span>\uff08\u5e38\u5e38\u9700\u8981\u964d\u7ef4\uff09<\/span>\uff0c\u65e0\u6cd5\u6ee1\u8db3\u91cf\u5316\u7ec6\u80de\u5185\u4fe1\u606f\u4f20\u8f93\u7684\u4fe1\u606f\u8bba\u65b9\u6cd5\u6240\u8981\u6c42\u7684\u9ad8\u5206\u8fa8\u7387\u3002<\/span><\/p>\n


<\/p>\n

2.\u5355\u5206\u5b50\u8367\u5149\u539f\u4f4d\u6742\u4ea4<\/span>\uff08Single molecule fluorescence in situ hybridization (smFISH)\uff09<\/span>\u3002\u4f5c\u4e3a\u4e00\u79cd\u57fa\u4e8e\u6210\u50cf\u7684\u6280\u672f\uff0csmFISH\u80fd\u591f\u6d4b\u91cf\u6765\u81ea\u4e8e\u5927\u7ea610000\u4e2a\u7ec6\u80de\u7684\u5185\u6e90\u6027\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u4f46\u662f\uff0csmFISH\u9700\u8981\u4fee\u590d\u6837\u672c\u5e76\u4e14\u53ea\u5728\u5355\u4e2a\u65f6\u95f4\u70b9\u6d4b\u91cf\uff0c\u65e0\u6cd5\u91cf\u5316\u968f\u65f6\u95f4\u63a8\u79fb\u7684\u4fe1\u606f\u4f20\u8f93\u3002<\/span><\/p>\n


<\/p>\n

3.\u6d3b\u7ec6\u80de\u6210\u50cf<\/span>\uff08live-cell imaging\uff09<\/span>\u3002\u6d3b\u7ec6\u80de\u6210\u50cf\u662f\u4e00\u79cd\u5b9e\u65f6\u6d4b\u91cf\u6d3b\u7ec6\u80de\u4fe1\u53f7\u6d3b\u52a8\u7684\u76f4\u63a5\u65b9\u6cd5\u3002\u65f6\u95f4\u5206\u8fa8\u7387\u8fbe\u5230\u5206\u949f\u7ea7\uff0c\u53ef\u4ee5\u6301\u7eed\u6570\u5929\u3002\u6bcf\u6b21\u5b9e\u9a8c\u53ef\u5927\u7ea6\u6d4b\u91cf1000\u4e2a\u7ec6\u80de\uff0c\u4f46\u662f\u5728\u540c\u65f6\u6d4b\u91cf\u4fe1\u53f7\u5206\u5b50\u7684\u6570\u91cf\u4e0a\u6709\u6240\u9650\u5236\uff0c\u901a\u5e38\u53ea\u80fd\u63a2\u6d4b\u5230\u4e00\u4e2a\u6216\u4e24\u4e2a\u5206\u5b50\u3002\u6d3b\u7ec6\u80de\u6210\u50cf\u548csmFISH\u5728\u4f18\u7f3a\u70b9\u4e0a\u662f\u4e92\u8865\u7684\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u57fa\u4e8e\u4ee5\u4e0a\u6570\u636e\u7279\u70b9\uff0c\u4f5c\u8005\u4e3b\u8981\u56de\u987e\u4e86\u4f7f\u7528\u6d3b\u7ec6\u80de\u6210\u50cf\u7684\u65b9\u6cd5\u3002<\/span><\/p>\n


<\/p>\n

1. \u5355\u65f6\u95f4\u70b9\u6570\u636e\u7684\u4e92\u4fe1\u606f\u548c\u4fe1\u9053\u5bb9\u91cf<\/span><\/strong><\/span><\/span><\/p>\n


<\/span><\/p>\n

\u539f\u6587\u5f15\u6587[113\uff0c114]\u662f\u4e00\u9879\u4ece\u5355\u7ec6\u80de\u4fe1\u53f7\u6d3b\u52a8\u4e2d\u91cf\u5316\u4fe1\u606f\u4f20\u8f93\u7684\u5f00\u521b\u6027\u5de5\u4f5c\uff0c\u4f5c\u8005\u5728[113]\u4e2d\u4f30\u8ba1\u4e86\u5355\u65f6\u95f4\u70b9\u7684\u4e92\u4fe1\u606f\u548c\u4fe1\u9053\u5bb9\u91cf\u3002\u5728\u6bcf\u4e2a\u65f6\u95f4\u70b9\u4e0b\uff0c\u5728\u786e\u5b9a\u7684\u523a\u6fc0\u6761\u4ef6\u4e0b\u6d4b\u91cf\u5f97\u5230\u7684\u5355\u7ec6\u80de\u54cd\u5e94\u5e8f\u5217\u4f1a\u5305\u542b\u4fe1\u53f7\u6d3b\u52a8\u5728\u7ec6\u80de\u95f4\u7684\u5206\u5e03\u60c5\u51b5\u4fe1\u606f\uff0c\u800c\u4e0d\u540c\u523a\u6fc0\u6761\u4ef6\u4e0b\u7684\u5206\u5e03\u5c31\u4e3a\u533a\u5206\u5916\u754c\u523a\u6fc0\u63d0\u4f9b\u4e86\u53ef\u8ba1\u7b97\u7684\u4e92\u4fe1\u606f\u3002\u4e92\u4fe1\u606f\u7684\u8ba1\u7b97\u4f1a\u53d7\u5230\u566a\u58f0\u548c\u53cd\u9988\u8c03\u8282\u7684\u5f71\u54cd\uff0c\u90a3\u4e48\u5b83\u4eec\u662f\u5982\u4f55\u5f71\u54cd\u4ee5\u53ca\u5982\u4f55\u5904\u7406\u5462\uff1f\u611f\u5174\u8da3\u7684\u8bfb\u8005\u53ef\u4ee5\u53c2\u8003\u539f\u6587\u5f15\u6587[28\uff0c116\uff0c114\uff0c117~119]\u3002<\/span><\/p>\n


<\/p>\n

2. \u5411\u91cf\u6cd5\u7528\u4e8e\u8ba1\u7b97\u591a\u65f6\u95f4\u70b9\u6570\u636e\u7684\u4fe1\u606f<\/span><\/strong><\/span><\/span><\/p>\n


<\/p>\n

\u539f\u6587\u5f15\u6587[62]\u5728\u91cf\u5316\u4fe1\u53f7\u54cd\u5e94\u8fc7\u7a0b\u4e2d\u7684\u4fe1\u606f\u4f20\u9012\u65b9\u9762\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\u3002\u8fd9\u7c7b\u65b9\u6cd5\u5c06\u6bcf\u4e2a\u5355\u7ec6\u80de\u7684\u65f6\u95f4\u5e8f\u5217\u4f5c\u4e3a\u4e00\u4e2a\u591a\u5143\u5411\u91cf\uff0c\u5e76\u4f7f\u7528k\u8fd1\u90bb\u4f30\u8ba1\u65f6\u95f4\u5e8f\u5217\u7684\u6982\u7387[121,122]\u3002\u867d\u7136\u8be5\u65b9\u6cd5\u53ef\u4ee5\u8bc4\u4f30\u4e00\u6bb5\u65f6\u95f4\u8fc7\u7a0b\u7684\u4fe1\u606f\uff0c\u4f46\u76ee\u524d\u5bf9\u6765\u81ea\u6d3b\u7ec6\u80de\u6210\u50cf\u6570\u636e\u7684\u7ec6\u80de\u6570\u91cf\u6709\u9650\u5236\uff0c\u96be\u4ee5\u51c6\u786e\u4f30\u8ba1\u8fc7\u7a0b\u7684\u65f6\u957f\u3002\u6b64\u5916\uff0c\u5c06\u65f6\u95f4\u5e8f\u5217\u89c6\u4e3a\u5411\u91cf\u4f7f\u5f97\u5bc6\u5ea6\u4f30\u8ba1\u4e0e\u65f6\u95f4\u70b9\u7684\u987a\u5e8f\u65e0\u5173\uff0c\u56e0\u6b64\u65e0\u6cd5\u533a\u5206\u65f6\u95f4\u5e8f\u5217\u4e2d\u7f16\u7801\u7684\u52a8\u529b\u5b66\u6a21\u5f0f\u3002<\/span><\/p>\n


<\/p>\n

3. \u5411\u91cf\u6cd5\u8ba1\u7b97\u52a8\u529b\u5b66\u7279\u5f81\u6240\u542b\u7684\u4fe1\u606f<\/span><\/strong><\/span><\/span><\/p>\n


<\/p>\n

\u54cd\u5e94\u4fe1\u53f7\u7684\u52a8\u529b\u5b66\u7279\u5f81<\/span>\uff08\u5982\u901a\u8fc7\u8c03\u63a7\u8f6c\u5f55\u56e0\u5b50\u6d3b\u6027\u7684\u5e45\u5ea6\u548c\u9891\u7387\uff09<\/span>\u4e5f\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u91cf\u5316\u7ec6\u80de\u5185\u7684\u4fe1\u606f\u4f20\u9012[128,129]\u3002\u793a\u610f\u56fe\u7b80\u8ff0\u4e86\u901a\u8fc7\u54cd\u5e94\u4fe1\u53f7\u7684\u52a8\u529b\u5b66\u7279\u5f81\u5bf9\u4fe1\u606f\u4f20\u9012\u8fdb\u884c\u91cf\u5316[115]\u3002\u901a\u8fc7\u52a0\u5165\u52a8\u529b\u5b66\u7279\u5f81\uff0c\u53ef\u4ee5\u63d0\u53d6\u51fa\u66f4\u591a\u7f16\u7801\u5728\u8f68\u8ff9\u4e2d\u7684\u4fe1\u606f[115]\u3002\u540c\u65f6\u53ef\u4ee5\u63ed\u793a\u63d0\u9ad8\u523a\u6fc0\u5206\u7c7b\u7684\u6700\u5177\u4fe1\u606f\u91cf\u7684\u7279\u5f81\u3002<\/span><\/p>\n


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<\/p>\n

\u56fe3. \u5411\u91cf\u6cd5\u7528\u4e8e\u52a8\u529b\u5b66\u7279\u5f81\u7684\u8ba1\u7b97\u6765\u91cf\u5316\u4fe1\u606f\u4f20\u9012\u3002a.\u8ba1\u7b97\u4e86NFKB\u957f\u65f6\u95f4\u5e8f\u5217\u7684\u52a8\u529b\u5b66\u7279\u5f81\u5e93\u3002b.\u901a\u9053\u5bb9\u91cf\u901a\u8fc7\u5bf9\u4fe1\u606f\u91cf\u6700\u9ad8\u7684\u52a8\u529b\u5b66\u7279\u5f81\u7684k\u8fd1\u90bb\u6765\u4f30\u8ba1\uff0c\u5bf9\u4e8e\u6240\u6709\u523a\u6fc0\u548c\u4e00\u4e2a\u523a\u6fc0\u7684\u4e0d\u540c\u5242\u91cf\uff0c\u5982\u4e0a\u6240\u793a\u3002c.\u641c\u7d22\u4fe1\u606f\u91cf\u6700\u9ad8\u7684\u7ec4\u5408\u7279\u5f81\u7684\u6d41\u7a0b[115]\u3002<\/span><\/section>\n


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\u4e09\u3001\u57fa\u4e8e\u673a\u5668\u5b66\u4e60\u7684\u91cf\u5316\u4fe1\u606f\u4f20\u9012\u7684\u65b9\u6cd5<\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


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\u73b0\u5982\u4eca\uff0c\u968f\u7740\u8ba1\u7b97\u673a\u7b97\u529b\u63d0\u9ad8\uff0c\u673a\u5668\u5b66\u4e60\u7b49\u8ba1\u7b97\u65b9\u6cd5\u53d1\u5c55\u8fc5\u901f\u3002\u5728\u63a2\u7a76\u91cf\u5316\u7ec6\u80de\u5185\u4fe1\u53f7\u901a\u9053\u7684\u4fe1\u606f\u6d41\u7684\u8def\u4e0a\uff0c\u57fa\u4e8e\u673a\u5668\u5b66\u4e60\u7684\u76f8\u8f83\u4e8e\u4ee5\u4e0a\u63d0\u5230\u7684\u65b9\u6cd5\u4f18\u52bf\u5728\u4e8e\u5904\u7406\u957f\u65f6\u7a0b\u7684\u65f6\u95f4\u5e8f\u5217[131~134]\u3002\u5728\u8fd9\u91cc\uff0c\u4f5c\u8005\u603b\u7ed3\u4e86\u4e09\u5927\u7c7b\u5178\u578b\u7684\u7528\u4e8e\u6b64\u9886\u57df\u7684\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\uff0c\u5206\u522b\u662f\u57fa\u4e8e\u89e3\u7801\u7684\u65b9\u6cd5[130]\u3001\u57fa\u4e8e\u7edf\u8ba1\u5b66\u4e60\u4f7f\u7528\u903b\u8f91\u65af\u8482\u56de\u5f52\u7684\u65b9\u6cd5\u3001\u57fa\u4e8e\u968f\u673a\u8fc7\u7a0b\u6a21\u578b\u6bd4\u5982\u9690\u9a6c\u5c14\u53ef\u592b\u6a21\u578b\u7684\u65b9\u6cd5\u3002<\/span><\/p>\n


<\/p>\n

1. \u57fa\u4e8e\u89e3\u7801\u5668\u8ba1\u7b97\u7684\u4e92\u4fe1\u606f<\/span><\/strong><\/span><\/p>\n


<\/span><\/p>\n

<\/p>\n

\u56fe4. \u57fa\u4e8e\u89e3\u7801\u7684\u65b9\u6cd5\u4ece\u4fe1\u53f7\u54cd\u5e94\u65f6\u95f4\u5e8f\u5217\u4e2d\u8ba1\u7b97\u4e92\u4fe1\u606f[130]<\/span><\/p>\n


<\/p>\n

\u8be5\u65b9\u6cd5\u9996\u5148\u901a\u8fc7\u5404\u4e2a\u523a\u6fc0\u6761\u4ef6\u4e0b\u7684\u6570\u636e\u8bad\u7ec3\u4e00\u4e2a\u5206\u7c7b\u5668\uff0c\u4e4b\u540e\u4f7f\u7528\u5176\u6765\u5bf9\u65b0\u7684\u7ec6\u80de\u76f8\u5e94\u4fe1\u53f7\u8fdb\u884c\u5206\u7ec4\u3002\u5b83\u80fd\u591f\u5bf9\u4e92\u4fe1\u606f\u7684\u4e0b\u754c\u8fdb\u884c\u4f30\u8ba1\uff0c\u5f53\u4f20\u7edf\u5206\u7c7b\u5668\u5982\u968f\u673a\u6811\u4f7f\u7528\u7ebf\u6027\u4e3b\u6210\u5206\u65f6\uff0c\u5b83\u4eec\u53ef\u80fd\u4e0d\u8db3\u4ee5\u533a\u5206\u632f\u8361\u8f68\u8ff9\u4fe1\u53f7\u548c\u975e\u632f\u8361\u8f68\u8ff9\u4fe1\u53f7\uff0c\u4e3a\u4e86\u514b\u670d\u8fd9\u4e2a\u95ee\u9898\uff0c\u5176\u4ed6\u673a\u5668\u5b66\u4e60\u6a21\u578b\u5982\u795e\u7ecf\u7f51\u7edc\uff0c\u53ef\u4ee5\u7528\u4e8e\u5206\u7c7b\u5668\u6765\u6539\u8fdb\u4f30\u8ba1\uff0c\u540c\u65f6\u4e92\u4fe1\u606f\u7684\u4e0a\u754c\u7684\u4f30\u8ba1\u4e5f\u662f\u73b0\u4eca\u7814\u7a76\u6781\u611f\u5174\u8da3\u7684\u65b9\u5411\u3002<\/span><\/p>\n


<\/p>\n

2. \u57fa\u4e8e\u7edf\u8ba1\u5b66\u4e60\u7684\u4e92\u4fe1\u606f\u4f30\u8ba1<\/span><\/strong><\/span><\/p>\n


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<\/p>\n

\u56fe5. a.\u533a\u5206\u4e24\u4e2a\u8f93\u5165\u6982\u7387\u793a\u610f\u56fe\u3002\u8f93\u5165\u5206\u5e03P(X)\u548c\u8f93\u51fa\u6761\u4ef6\u6982\u7387P(Y|X)\u4ee5\u53ca\u901a\u8fc7\u8d1d\u53f6\u65af\u516c\u5f0f\u63a8\u5bfc\u5f97\u5230\u7684\u6761\u4ef6\u8f93\u5165\u5206\u5e03P(X|Y)\u3002b.\u901a\u9053\u5bb9\u91cf\u4f5c\u4e3a\u65f6\u95f4\u7684\u51fd\u6570\uff0c\u5355\u72ec\u4f7f\u7528\u5355\u65f6\u95f4\u70b9\u6570\u636e\u548c\u65f6\u95f4\u5e8f\u5217\u3002c.\u5bf921\u5206\u949f\u7684TNF\u03b1\u6d53\u5ea6\u548c\u65f6\u95f4\u5e8f\u5217\u8fdb\u884c\u6b63\u786e\u7684\u4e24\u4e24\u533a\u5206\u7684\u6982\u7387(\u5706\u5708\u6807\u8bb0\u7684\u989c\u8272\u586b\u5145\u5206\u6570)[125]<\/span><\/section>\n


<\/p>\n

SLEMI<\/span>\uff08Statistical learning-based estimation of mutual information\uff09<\/span>\u65b9\u6cd5[125,127]\u9002\u7528\u4e8e\u9ad8\u7ef4\u7684\u4fe1\u53f7\u54cd\u5e94\u65f6\u95f4\u5e8f\u5217\uff0c\u540c\u65f6\u4e0d\u9650\u5236\u65f6\u95f4\u70b9\u7684\u6570\u91cf\u3002SLEMI\u4f7f\u7528\u57fa\u4e8e\u903b\u8f91\u65af\u8482\u56de\u5f52\u7684\u8d1d\u53f6\u65af\u6846\u67b6\u6765\u4f30\u8ba1\u7ed9\u5b9a\u8f68\u8ff9\u7684\u523a\u6fc0\u6982\u7387\u3002\u540c\u6837\uff0c\u7531\u4e8e\u903b\u8f91\u65af\u8482\u56de\u5f52\u5047\u8bbe\u5bf9\u8f68\u8ff9\u8fdb\u884c\u7ebf\u6027\u62df\u5408\u6765\u8ba1\u7b97\u4e0d\u540c\u523a\u6fc0\u6761\u4ef6\u4e0b\u8f68\u8ff9\u6982\u7387\u7684\u6bd4\u4f8b\uff0c\u56e0\u6b64\u8be5\u65b9\u6cd5\u662f\u5426\u80fd\u5b8c\u5168\u89e3\u91ca\u89c2\u6d4b\u5230\u7684\u4fe1\u53f7\u8f68\u8ff9\u590d\u6742\u7684\u52a8\u529b\u5b66\u6a21\u5f0f\uff0c\u5982\u632f\u8361\u884c\u4e3a\uff0c\u5c1a\u4e0d\u6e05\u695a\u3002\u5e94\u7528\u4e8e\u590d\u6742\u8f68\u8ff9\u65f6\uff0c\u4f30\u8ba1\u7684\u4e92\u4fe1\u606f\u53ef\u80fd\u4e0d\u592a\u51c6\u786e\uff0c\u8fd9\u79cd\u60c5\u51b5\u4e0b\u7684\u4e92\u4fe1\u606f\u8ba1\u7b97\u4e5f\u662f\u73b0\u4eca\u6d3b\u8dc3\u7684\u7814\u7a76\u65b9\u5411\u4e4b\u4e00\u3002<\/span><\/p>\n


<\/p>\n

3. \u968f\u673a\u6a21\u578b\u7684\u65b9\u6cd5<\/span><\/strong><\/span><\/p>\n


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<\/p>\n

\u56fe6. \u5229\u7528\u968f\u673a\u6a21\u578b\u5bf9\u52a8\u6001\u4e92\u4fe1\u606f\u8fdb\u884c\u91cf\u5316\u3002\u968f\u673a\u6a21\u578b\u5982\u9690\u9a6c\u5c14\u53ef\u592b\u6a21\u578b\u53ef\u4ee5\u7528\u6765\u5b66\u4e60\u4fe1\u53f7\u52a8\u529b\u5b66\u3001\u518d\u73b0\u6570\u636e\u3001\u63a8\u65ad\u8f68\u8ff9\u6982\u7387\u548c\u8bc4\u4f30\u4e92\u4fe1\u606f\u3002a.\u9690\u9a6c\u5c14\u53ef\u592b\u6a21\u578b\u3002b.\u53c2\u6570\u6570\u91cf\u5bf9\u6a21\u578b\u6027\u80fd\u7684\u5f71\u54cd\u3002c.\u4ece\u8bad\u7ec3\u597d\u7684\u968f\u673a\u6a21\u578b\u4e2d\u8ba1\u7b97\u4e92\u4fe1\u606f\u3002d.\u4f30\u8ba1\u7684\u4e92\u4fe1\u606f\u63ed\u793a\u4e86\u533a\u5206\u67d0\u4e9b\u523a\u6fc0\u5bf9\u7684\u65f6\u95f4\u987a\u5e8f\u3002[49]<\/span><\/section>\n


<\/p>\n

\u53d7\u5230\u8f68\u8ff9\u71b5\u7684\u542f\u53d1\uff0c\u6570\u636e\u53ef\u4ee5\u4ece\u8f68\u8ff9\u7684\u89c6\u89d2\u7406\u89e3[81]\u3002\u7814\u7a76\u8005\u5229\u7528\u4ee5\u5f80\u88ab\u5e38\u7528\u4e8e\u8bed\u97f3\u8bc6\u522b\u7684\u968f\u673a\u52a8\u529b\u5b66\u6a21\u578b[139]\uff0c\u5373\u9690\u9a6c\u5c14\u53ef\u592b\u6a21\u578b\uff0c\u6765\u5b66\u4e60\u548c\u91cd\u6784\u4fe1\u53f7\u76f8\u5e94\u5e8f\u5217\uff0c\u540c\u65f6\u8fdb\u4e00\u6b65\u751f\u6210\u8f68\u8ff9\u6982\u7387\u6765\u8ba1\u7b97\u4e92\u4fe1\u606f[49]\u3002\u8be5\u65b9\u6cd5\u80fd\u63ed\u793a\u4e92\u4fe1\u606f\u968f\u7740\u65f6\u95f4\u7684\u7d2f\u79ef\u73b0\u8c61\u3002<\/span><\/p>\n


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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n

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\u9664\u4e86\u4e0a\u8ff0\u7814\u7a76\u5916\uff0c\u8fdb\u4e00\u6b65\u7684\u53d1\u5c55\u5305\u62ec\u4f7f\u7528\u6700\u65b0\u7684\u673a\u5668\u5b66\u4e60\u65b9\u6cd5<\/span>\uff08\u5982\u9012\u5f52\u795e\u7ecf\u7f51\u7edc\uff0c\u57fa\u4e8e\u6ce8\u610f\u529b\u673a\u5236\u7684transformer\uff09<\/span>\uff0c\u5c06\u5176\u5e94\u7528\u4e8e\u5355\u7ec6\u80de\u4fe1\u53f7\u5e94\u7b54\uff0c\u53ef\u80fd\u5177\u6709\u66f4\u597d\u7684\u91cd\u6784\u6216\u9884\u6d4b\u7684\u6548\u679c\u3002\u5728\u66f4\u73b0\u5b9e\u7684\u73af\u5883\u4e2d\uff0c\u4f8b\u5982\u5728\u6df7\u5408\u81ea\u7136\u4fe1\u53f7\u7684\u523a\u6fc0\u4e0b\uff0c\u91cf\u5316\u4fe1\u606f\u4f20\u9012\u4e5f\u662f\u5f88\u6709\u610f\u601d\u7684\u65b9\u5411\u3002\u91cf\u5316\u5927\u7a7a\u95f4\u548c\u957f\u65f6\u95f4\u5c3a\u5ea6\u4e0a\u7684\u4fe1\u606f\u4f20\u8f93\u8fd8\u9700\u5f85\u8fdb\u4e00\u6b65\u53d1\u5c55\uff0c\u6bd4\u5982\u901a\u8fc7\u5377\u79ef\u795e\u7ecf\u7f51\u7edc\u6765\u63d0\u53d6\u7a7a\u95f4\u5206\u5e03\u7684\u4fe1\u606f\u3002\u4ece\u751f\u7269\u89d2\u5ea6\uff0c\u9664\u4e86\u4fe1\u53f7\u5206\u5b50\u5728\u5355\u7ec6\u80de\u4e2d\u4f20\u9012\u4fe1\u606f\u5916\uff0c\u4fe1\u53f7\u8f6c\u5bfc\u8fd8\u53d7\u5230\u7ec6\u80de\u7fa4\u7684\u5f71\u54cd\u3002\u7ec6\u80de\u4e9a\u7fa4\u5bf9\u523a\u6fc0\u53ef\u80fd\u4f5c\u51fa\u5206\u7ea7\u53cd\u5e94\uff0c\u5e76\u4e14\u5c06\u53cd\u5e94\u4fe1\u606f\u72ec\u7acb\u4f20\u9012\u3002\u7814\u7a76\u8fd9\u4e9b\u66f4\u590d\u6742\u7684\u751f\u7269\u8fc7\u7a0b\u4e2d\u7684\u4fe1\u606f\u4f20\u9012\u4e5f\u662f\u672a\u6765\u7814\u7a76\u7684\u65b9\u5411\u4e4b\u4e00\u3002<\/span><\/p>\n


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\u7531\u5317\u4eac\u5e08\u8303\u5927\u5b66\u6559\u6388\u3001\u96c6\u667a\u4ff1\u4e50\u90e8\u521b\u59cb\u4eba\u5f20\u6c5f\u548c\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u52a9\u7406\u6559\u6388\u5c24\u4ea6\u5e84\u7b49\u4eba\u53d1\u8d77\u7684\u300c\u56e0\u679c\u6d8c\u73b0\u300d\u7cfb\u5217\u8bfb\u4e66\u4f1a\u7b2c\u4e8c\u5b63<\/a>\uff0c\u5c06\u7ec4\u7ec7\u5bf9\u672c\u8bdd\u9898\u611f\u5174\u8da3\u7684\u670b\u53cb\uff0c\u6df1\u5165\u7814\u8bfb\u76f8\u5173\u6587\u732e\uff0c\u6fc0\u53d1\u79d1\u7814\u7075\u611f\u3002\u672c\u8bfb\u4e66\u4f1a\u81ea2022\u5e745\u670822\u65e5\u5f00\u59cb\uff0c\u6bcf\u5468\u65e5\u665a19:00\u4e3e\u529e\uff0c\u9884\u8ba1\u6301\u7eed7-8\u5468\u3002\u6b22\u8fce\u611f\u5174\u8da3\u7684\u670b\u53cb\u62a5\u540d\u53c2\u4e0e\u3002<\/span><\/section>\n

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