{"id":37001,"date":"2022-09-01T22:55:10","date_gmt":"2022-09-01T14:55:10","guid":{"rendered":"https:\/\/swarma.org\/?p=37001"},"modified":"2022-09-01T22:55:10","modified_gmt":"2022-09-01T14:55:10","slug":"%e7%a5%9e%e7%bb%8f%e5%85%83%e6%a8%a1%e5%9e%8b%ef%bc%9a%e4%bb%8e%e7%a6%bb%e5%ad%90%e9%80%9a%e9%81%93%e5%88%b0%e8%ae%a1%e7%ae%97","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=37001","title":{"rendered":"\u795e\u7ecf\u5143\u6a21\u578b\uff1a\u4ece\u79bb\u5b50\u901a\u9053\u5230\u8ba1\u7b97"},"content":{"rendered":"
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\u5bfc\u8bed<\/strong><\/p>\n<\/section>\n<\/section>\n

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\u672c\u7bc7\u63a8\u6587\u6765\u81ea\u96c6\u667a\u4ff1\u4e50\u90e8\u7684\u7f51\u7ad9\u96c6\u667a\u6591\u56fe\u7684\u4e00\u7bc7\u8def\u5f84\u300a\u795e\u7ecf\u5143\u6a21\u578b\uff1a\u4ece\u79bb\u5b50\u901a\u9053\u5230\u8ba1\u7b97<\/a>\u300b\uff0c\u8def\u5f84\u57fa\u4e8e\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u8bfb\u4e66\u4f1a<\/a>\u7b2c\u4e00\u5b63\u81e7\u8574\u4eae\u8001\u5e08\u7684\u5206\u4eab\u6574\u7406\u800c\u6210\u3002\u611f\u5174\u8da3\u7684\u670b\u53cb\u53ef\u4ee5\u7ed3\u5408\u672c\u6b21\u5206\u4eab\u7684\u56de\u653e\uff08\u56de\u653e\u94fe\u63a5https:\/\/campus.swarma.org\/course\/4433\uff09\u8fdb\u884c\u5b66\u4e60\u3002<\/span><\/p>\n


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\u5206\u4eab\u5185\u5bb9\u7b80\u4ecb\uff1a\u5927\u8111\u4e2d\u4fe1\u606f\u4f20\u9012\u4e3b\u8981\u662f\u901a\u8fc7\u5e95\u5c42\u7684\u795e\u7ecf\u5143\u4ea7\u751f\u5e76\u4f20\u9012\u4e0d\u540c\u5f62\u5f0f\u7684\u8109\u51b2\u6765\u5b9e\u73b0\u7684\u3002\u56e0\u6b64\u4e86\u89e3\u795e\u7ecf\u5143\u5982\u4f55\u5904\u7406\u3001\u4f20\u9012\u4fe1\u606f\u5bf9\u7406\u89e3\u73af\u8def\u4ee5\u53ca\u8111\u5b9e\u73b0\u76f8\u5e94\u529f\u80fd\u7684\u673a\u7406\u6709\u7740\u91cd\u8981\u610f\u4e49\u3002\u4e3b\u8bb2\u4eba\u4ece\u5e38\u7528\u7684\u795e\u7ecf\u5143\u5efa\u6a21\u65b9\u6cd5\u53ca\u5176\u7f3a\u9677\u8bb2\u8d77\uff0c\u7136\u540e\u4ecb\u7ecd\u4e0d\u540c\u79cd\u7c7b\u795e\u7ecf\u5143\u7684\u8ba1\u7b97\u7279\u6027\uff08\u5982type I\u548ctype II\uff09\uff0c\u5e76\u56f4\u7ed5\u8fd9\u4e9b\u7279\u6027\u4ee5\u53ca\u76f8\u5173\u8bba\u6587\uff0c\u91cd\u70b9\u8ba8\u8bba\u57fa\u4e8e\u795e\u7ecf\u5143\u6a21\u578b\u7684\u7814\u7a76\u65b9\u5411\u53ca\u8fdb\u5c55\uff0c\u6700\u540e\u5bf9\u795e\u7ecf\u5143\u6a21\u578b\u7684\u7814\u7a76\u70ed\u70b9\u8fdb\u884c\u5c55\u671b\u3002<\/span><\/p>\n


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\u5b66\u4e60\u96be\u5ea6\uff1a\u96be\u5ea6\u9002\u4e2d<\/span><\/p>\n


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\u9605\u8bfb\u57fa\u7840\uff1a\u7b80\u5355\u4e86\u89e3\u795e\u7ecf\u5143\u7535\u751f\u7406\u3001\u795e\u7ecf\u5143\u6811\u7a81\u8ba1\u7b97\u3001\u795e\u7ecf\u7f51\u7edc\u5927\u89c4\u6a21\u73af\u8def\u4eff\u771f\u7684\u77e5\u8bc6\u4f1a\u5bf9\u7406\u89e3\u5927\u6709\u88e8\u76ca\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u81e7\u8574\u4eae<\/span><\/strong><\/span><\/strong> <\/span>| \u8bb2\u8005<\/strong><\/span><\/strong><\/span><\/p>\n

Erfan <\/span>| \u6574\u7406<\/strong><\/span><\/strong><\/p>\n

\u9093\u4e00\u96ea<\/span> <\/span>| <\/strong><\/span>\u7f16\u8f91<\/strong><\/p>\n


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\u76ee\u5f55<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

1. \u80cc\u666f<\/span><\/section>\n

\u795e\u7ecf\u5143\u7684\u7ed3\u6784\u7279\u6027\u4e0e\u8109\u51b2\u653e\u7535\u8fc7\u7a0b<\/span><\/p>\n

2. \u795e\u7ecf\u5143\u5efa\u6a21\u65b9\u6cd5<\/span><\/section>\n

Hodgkin-Huxley model<\/span><\/p>\n

Compartment model<\/span><\/p>\n

Integrate-and-Fire model<\/span><\/p>\n

\u5982\u4f55\u9009\u62e9\u6a21\u578b<\/span><\/p>\n

3. \u795e\u7ecf\u5143\u8ba1\u7b97\u7279\u6027<\/span><\/section>\n
4. \u795e\u7ecf\u5143\u76f8\u5173\u7814\u7a76\u8fdb\u5c55<\/span><\/section>\n

\u4e0e\u9002\u65f6\u72b6\u6001\u76f8\u5173\u8bef\u5dee\u5b66\u4e60<\/span><\/p>\n

\u795e\u7ecf\u5143\u591a\u8def\u590d\u7528\u7f16\u7801<\/span><\/p>\n

\u795e\u7ecf\u5143\u529f\u80fd\u96c6\u7fa4\u52a8\u6001\u5f62\u6210<\/span><\/p>\n

\u4e2a\u4f53\u5dee\u5f02\u6027\u4e0e\u7a33\u6001\u53ef\u5851\u6027<\/span><\/p>\n

\u795e\u7ecf\u8c03\u63a7\u4e0d\u540c\u65b9\u5411<\/span><\/p>\n

\u7a33\u6001\u53ef\u5851\u6027\u4e4b\u7ed3\u6784\u53d8\u6362<\/span><\/p>\n

5. \u795e\u7ecf\u5143\u5efa\u6a21\u672a\u6765\u53d1\u5c55\u65b9\u5411<\/span><\/section>\n

\u6a21\u578b\u7b80\u5316\u5230\u5927\u73af\u8def<\/span><\/p>\n

\u66f4\u5fae\u89c2\u7684\u5b9e\u9a8c\u6570\u636e<\/span><\/p>\n

\u7269\u79cd\u7684\u533a\u522b<\/span><\/p>\n

\u66f4\u590d\u6742\u7684\u8ba1\u7b97\u529f\u80fd<\/span><\/p>\n

\u795e\u7ecf\u5143AI<\/span><\/p>\n


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1. \u80cc\u666f<\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n

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\u4f20\u7edf\u7406\u8bba\u8ba4\u4e3a\uff0c\u5927\u8111\u5177\u6709\u4e0d\u540c\u7684\u5206\u533a\uff0c\u5404\u53f8\u5176\u804c\uff0c\u56e0\u6b64\u5bf9\u8111\u7684\u7814\u7a76\u4e00\u822c\u4ee5\u8111\u533a\u4e3a\u5355\u4f4d\u3002\u4f46\u8fd1\u4e9b\u5e74\u53d1\u73b0\u8111\u533a\u7684\u529f\u80fd\u5212\u5206\u5e76\u4e0d\u7edd\u5bf9\uff0c\u8fdc\u6bd4\u73b0\u6709\u8ba4\u77e5\u66f4\u590d\u6742\u3002\u6bd4\u5982\u5c0f\u8111\u4e0d\u4ec5\u8d1f\u8d23\u8fd0\u52a8\u76f8\u5173\u529f\u80fd\uff0c\u4e5f\u53ef\u4ee5\u53c2\u4e0e\u793e\u4ea4\u3001\u611f\u60c5\u3001\u51b3\u7b56\u7b49\u8fc7\u7a0b\u3002<\/span><\/section>\n

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\u795e\u7ecf\u5143\u7684\u7ed3\u6784\u7279\u6027\u4e0e\u8109\u51b2\u653e\u7535\u8fc7\u7a0b<\/span><\/strong><\/span><\/section>\n

<\/span><\/section>\n<\/h2>\n
\u8111\u53ca\u795e\u7ecf\u5143\u4e4b\u95f4\u7684\u8fde\u63a5\u5f02\u5e38\u590d\u6742\uff0c\u6bd4\u5982\u8981\u4e86\u89e3\u89c6\u89c9\u5b9e\u73b0\u7684\u8fc7\u7a0b\uff0c\u5728\u5c0f\u9f20\u4e2d\u534a\u5f84845\u5fae\u7c73\u7684\u4e00\u5c0f\u5757\u521d\u7ea7\u89c6\u89c9\u76ae\u8d28V1\u533a\u5c31\u5305\u542b23\u4e07\u4e2a\u795e\u7ecf\u5143\uff0c\u60f3\u5b8c\u5168\u89e3\u6784\u8fd9\u4e9b\u795e\u7ecf\u5143\u7684\u7535\u751f\u7406\u6d3b\u52a8\u51e0\u4e4e\u4e0d\u53ef\u80fd\uff0c\u5728\u6b64\u80cc\u666f\u4e0b\uff0c\u8ba1\u7b97\u795e\u7ecf\u79d1\u5b66\u5c31\u6210\u4e3a\u4e86\u89e3\u8111\u5de5\u4f5c\u673a\u5236\u7684\u91cd\u8981\u5de5\u5177[1]\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u4eba\u8111\u6709\u7ea61000\u4ebf\u4e2a\u795e\u7ecf\u5143\uff0c\u795e\u7ecf\u5143\u4e4b\u95f4\u7684\u4fe1\u606f\u4f20\u9012\u2014\u7535\u6216\u5316\u5b66\u6d3b\u52a8\u9519\u7efc\u590d\u6742\uff0c\u4fe1\u606f\u6574\u5408\u53d1\u751f\u5728\u8f74\u7a81\u521d\u6bb5<\/span>\uff08Axon Initial Segment\uff0cAIS\uff09<\/span>\uff0c\u60f3\u8981\u4e86\u89e3\u66f4\u591a\u53ef\u4ee5\u53c2\u8003\u5173\u4e8e[\u8111]<\/span>(https:\/\/zh.wikipedia.org\/wiki\/%25E8%2584%2591) <\/span>\u7684\u767e\u79d1\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u4e0a\u4e16\u7eaa50\u5e74\u4ee3\uff0c\u6280\u672f\u624b\u6bb5\u843d\u540e\uff0c\u5927\u5bb6\u53ea\u80fd\u5728\u6d77\u6d0b\u52a8\u7269\u7c97\u5927\u7684\u8f74\u7a81\u4e0a\u505a\u7535\u4fe1\u53f7\u8bb0\u5f55\uff0c\u4e0b\u8fb9\u8fd9\u7bc7\u662f\u7efc\u5408\u4e4b\u524d\u4e00\u7cfb\u5217\u5b9e\u9a8c\u6d4b\u91cf\u4e4b\u540e\u5173\u4e8e\u7535\u4fe1\u53f7\u5efa\u6a21\u7684\u96c6\u5927\u6210\u8005\uff0c\u63a8\u8350\u5927\u5bb6\u9605\u8bfb[2]\u3002<\/span><\/section>\n

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2. \u795e\u7ecf\u5143\u5efa\u6a21\u65b9\u6cd5<\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n

<\/section>\n

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Hodgkin-Huxley model<\/span><\/strong><\/span><\/section>\n

<\/span><\/strong><\/span><\/section>\n<\/h2>\n
\u795e\u7ecf\u5143\u7b49\u6548\u4e8eRC\u7535\u8def\uff0c\u7535\u5bb9\u5668\uff0c\u591a\u79cd\u7535\u6d41\u3001\u7535\u52bf\u5dee\u3002<\/span><\/section>\n
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\u7535\u5bb9\u5668\uff1a\u7ec6\u80de\u5185\u5916\u79bb\u5b50\u5747\u5bfc\u7535\uff0c\u4e2d\u95f4\u7a7f\u63d2\u78f7\u8102\u53cc\u5206\u5b50\u5c42\u662f\u7edd\u7f18\u4f53\uff0c\u56e0\u6b64\u7b49\u6548\u4e8e\u7535\u5bb9\u5668\u3002\u5b9e\u9a8c\u4e2d\u7535\u5bfc\u65e0\u6cd5\u76f4\u63a5\u6d4b\u91cf\uff0c\u901a\u8fc7\u57fa\u5c14\u970d\u592b\u5b9a\u5f8b\u53ef\u4ee5\u8ba1\u7b97\u7535\u5bfc\u3002<\/span><\/section>\n
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\u7535\u538b\u95e8\u63a7\u7535\u6d41\uff1a\u7ec6\u80de\u5185\u7535\u52bf\u7684\u5347\u9ad8\uff0c\u6539\u53d8\u4e86\u4e86\u7535\u538b\u95e8\u63a7\u79bb\u5b50\u901a\u9053\u7684\u6784\u8c61\uff0c\u4f7f\u901a\u9053\u5448\u5f00\u653e\u72b6\u6001\uff0c\u5141\u8bb8\u79bb\u5b50\u5728\u6d53\u5ea6\u5dee\u7684\u9a71\u52a8\u4e0b\u6d41\u52a8\u4ea7\u751f\u7535\u6d41\u3002<\/span><\/section>\n
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\u7535\u52bf\u5dee\uff1a\u7ec6\u80de\u5185\u5916\u591a\u79cd\u79bb\u5b50\u6d53\u5ea6\u7684\u5dee\u5f02<\/span>\uff08\u7531\u4e8e\u7ec6\u80de\u819c\u7684\u5206\u9694\uff09<\/span>\u5bfc\u81f4\u7535\u52bf\u5dee\u7684\u51fa\u73b0\u3002\u901a\u9053\u6253\u5f00\uff0c\u52bf\u80fd\u53ef\u4ee5\u8f6c\u5316\u4e3a\u7535\u80fd\u3002<\/span><\/section>\n
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\u5206\u79bb\u94a0\u7535\u6d41\u4ee5\u53ca\u94be\u7535\u6d41<\/span>\uff08\u5f53\u7ec6\u80de\u5185\u5916\u94a0\u79bb\u5b50\u6d53\u5ea6\u76f8\u540c\u65f6\uff0c\u94a0\u7535\u6d41\u4e3a0\uff0c\u56e0\u6b64\u6d4b\u5f97\u7535\u6d41\u5b9e\u9645\u4e3a\u94be\u7535\u6d41\u3002\u7136\u540e\u901a\u8fc7\u751f\u7406\u72b6\u6001\u4e0b\u6d4b\u5f97\u7684\u94a0\u94be\u7efc\u5408\u7535\u6d41\u51cf\u53bb\u524d\u9762\u6d4b\u5f97\u7684\u94be\u7535\u6d41\u5373\u4e3a\u94a0\u7535\u6d41\uff09<\/span>\uff0c\u518d\u6839\u636e\u7535\u6d41\u3001\u7535\u538b\u8ba1\u7b97\u7535\u5bfc\u503c<\/span>\uff08\u7535\u6d41\u7684\u7a33\u6001\u503c\uff09<\/span>\uff0c\u5982\u4e0b\u56fe\u6240\u793a\u3002<\/span><\/section>\n
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\u7535\u6d41\u5e45\u5ea6\u7684\u53d8\u5316\u4e0d\u662f\u7a81\u7136\u4e8c\u8fdb\u5236\u9636\u8dc3\u53d8\u5316<\/span>\uff08\u4ece0\u52301\uff09<\/span>\uff0c\u800c\u662f\u968f\u7740\u65f6\u95f4\u9010\u6e10\u8fbe\u5230\u7a33\u6001\u7684\uff0c\u56e0\u6b64\u8981\u5bf9\u8fd9\u4e2a\u65f6\u95f4\u8fc7\u7a0b\u8fdb\u884c\u5efa\u6a21<\/span>\uff08\u5f53\u65f6\u4eba\u4eec\u5e76\u4e0d\u77e5\u9053\u5355\u4e2a\u79bb\u5b50\u901a\u9053\u7684\u5b58\u5728\uff0c\u53ea\u80fd\u4ece\u5b8f\u89c2\u4e0a\u7406\u89e3\u7535\u6d41\uff0c\u5e76\u4e14\u5c06\u5b8f\u89c2\u7535\u6d41\u7406\u89e3\u6210\u4e0d\u540c\u7684particle\u5904\u4e8e0\u62161\u6001\uff0c\u8fd9\u4e00\u731c\u6d4b\u9884\u793a\u7740\u79bb\u5b50\u901a\u9053\u7ed3\u6784\u7684\u5b58\u5728\uff0c\u540e\u7eed\u901a\u8fc7\u819c\u7247\u94b3\u6280\u672f\u5f97\u4ee5\u8bc1\u5b9e\u3002\uff09<\/span>\u3002<\/span><\/section>\n
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1991\u5e74\u7684\u8bfa\u5956\u7814\u7a76\uff0c\u8bc1\u660e\u5355\u4e2a\u79bb\u5b50\u901a\u9053\u7684\u5b58\u5728\uff0c\u4f7f\u7528\u5230\u4e86\u819c\u7247\u94b3\u6280\u672f\u3002<\/span><\/section>\n
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<\/section>\n
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HH\u6a21\u578b\u76f4\u5230\u4eca\u5929\u4f9d\u7136\u662f\u6211\u4eec\u7814\u7a76\u795e\u7ecf\u7535\u751f\u7406\u7684\u57fa\u77f3\uff0c\u4f46\u662f\u5728\u67d0\u4e9b\u6761\u4ef6\u4e0b\u5b83\u5b58\u5728\u7740\u4e00\u5b9a\u7f3a\u9677\u3002Clay\u5bf9\u6bd4\u4e86HH\u6a21\u578b\u4e0eGHK\u6a21\u578b\u7684\u5dee\u522b\uff0c\u53d1\u73b0\u7406\u60f3\u60c5\u51b5\u4e0b\u901a\u8fc7GHK\u6a21\u578b\u83b7\u5f97\u7684\u7a33\u6001\u6fc0\u6d3b\u66f2\u7ebf\uff0c\u66f4\u52a0\u543b\u5408\u5b9e\u9a8c\u83b7\u5f97\u7684\u66f2\u7ebf\u3002\u4f46\u662f\u5982\u679c\u7ec6\u80de\u5916\u5b58\u5728\u5927\u91cf\u9499\u79bb\u5b50\u3001\u9541\u79bb\u5b50\u7b492\u4ef7\u9633\u79bb\u5b50\uff0c\u4f1a\u5f71\u54cd\u94a0\u79bb\u5b50\u7684\u7ed3\u5408\u4f4d\u70b9\uff0c\u4ece\u800c\u5f71\u54cdIV\u66f2\u7ebf<\/span>\uff08\u4f7f\u5176\u5448\u7ebf\u6027\uff09<\/span>\u3002\u5728\u9c7f\u9c7c\u5927\u8f74\u7a81\u4e2d\u5b58\u5728\u5927\u91cf\u7684\u9499\u79bb\u5b50\u548c\u9541\u79bb\u5b50\uff0c\u8bef\u6253\u8bef\u649e\u4f7f\u5f97\u94be\u7535\u6d41\u66f2\u7ebf\u80fd\u591f\u88abHH\u6a21\u578b\u5b8c\u7f8e\u62df\u5408\u3002\u800c\u54fa\u4e73\u52a8\u7269\u4f53\u5185\u7684IV\u66f2\u7ebf\u53ef\u80fd\u4ecb\u4e8e\u76f4\u7ebf\u4e0e\u66f2\u7ebf\u4e4b\u95f4\u3002\u56e0\u6b64\uff0c\u9488\u5bf9\u4e0d\u540c\u7814\u7a76\u76ee\u7684\u9700\u8981\u4ed4\u7ec6\u8003\u91cf\u4e24\u79cd\u6a21\u578b\u7684\u9009\u62e9[3]\u3002<\/span><\/section>\n

<\/span><\/section>\n

\n
Compartment model<\/span><\/strong><\/span><\/section>\n

<\/span><\/section>\n<\/h2>\n
\u8fc7\u53bb\u7684\u7814\u7a76\u8005<\/span>\uff08John Eccles\u7b49\uff09<\/span>\u8ba4\u4e3a\u6811\u7a81\u4ec5\u4ec5\u63a5\u6536\u4fe1\u606f\uff0c\u7531\u80de\u4f53\u5904\u7406\u4fe1\u606f\uff0c\u4ee5\u80de\u4f53\u4e3a\u4e2d\u5fc3[4]\u3002<\/span><\/section>\n
 <\/span><\/section>\n
 <\/span><\/section>\n
Wilfrid Rall\u63d0\u51fa\u4e86<\/span>[Cable_theory](http:\/\/en.wikipedia.org\/wiki\/Cable_theory)\uff08Compartment\u6a21\u578b\uff09<\/span>\uff0c\u5c06\u795e\u7ecf\u5143\u7684\u51e0\u4f55\u7ed3\u6784\u79bb\u6563\u6210\u8bb8\u591a\u7a7a\u95f4\u5c0f\u5355\u5143\uff0c\u6700\u5f00\u59cb\u6ca1\u6709\u8003\u8651\u79bb\u5b50\u7535\u6d41\uff0c\u6bcf\u4e2a\u5c0f\u5355\u5143\u7b49\u6548\u4e3a\u4e00\u4e2a\u88ab\u52a8\u7684RC\u7b49\u6548\u7535\u8def\u3002\u4e0d\u540c\u5c0f\u5355\u5143\u4e4b\u95f4\u901a\u8fc7\u7535\u6d41\u7684\u6269\u6563\u8fc7\u7a0b\uff0c\u4f7f\u7535\u4fe1\u53f7\u4f20\u64ad\u3002\u8fd9\u91cc\u53ef\u4ee5\u8fd1\u4f3c\u6210\u4e00\u7ef4\u65b9\u5411\u7684\u4f20\u5bfc\uff0c\u56e0\u6b64\u53ef\u4ee5\u7528\u5355\u4e2a\u53d8\u91cf\u7684\u504f\u5fae\u5206\u65b9\u7a0b\u53bb\u63cf\u8ff0\u3002\u53cd\u5e94-\u6269\u6563\u65b9\u7a0b\u53ef\u4ee5\u81ea\u5df1\u901a\u8fc7\u6709\u9650\u5dee\u5206\u6cd5\u6c42\u89e3\u6216\u8005\u901a\u8fc7NEURON\u8f6f\u4ef6\u8c03\u53c2\u6c42\u89e3\u3002<\/span><\/section>\n

<\/span><\/section>\n

\n
Integrate-and-Fire model<\/span><\/strong><\/span><\/section>\n

<\/span><\/section>\n<\/h2>\n
\u6574\u5408\u53d1\u653e\u6a21\u578b\uff0c\u5e7f\u6cdb\u5e94\u7528\u5728\u5927\u89c4\u6a21\u73af\u8def\u4eff\u771f\u548c\u8109\u51b2\u795e\u7ecf\u7f51\u7edc\u4e2d\u3002<\/span><\/section>\n
 <\/span><\/section>\n
<\/section>\n
 <\/span><\/section>\n
\u4f46\u662f\u5b83\u6ca1\u6709\u79bb\u5b50\u7535\u6d41\uff0c\u795e\u7ecf\u5143\u63a5\u53d7\u8db3\u591f\u5f3a\u8db3\u591f\u5bc6\u96c6\u7684\u523a\u6fc0\u540e\uff0c\u6709\u4e00\u5b9a\u51e0\u7387\u4f7f\u7535\u52bf\u5dee\u8fbe\u5230\u8109\u51b2\u6fc0\u53d1\u9608\u503c\uff0c\u8fdb\u800c\u6fc0\u53d1\u4e00\u6b21\u8109\u51b2\uff0c\u63a5\u7740\u56de\u5230\u9759\u606f\u6c34\u5e73\u3002<\/span><\/section>\n
 <\/span><\/section>\n
<\/section>\n
 <\/span><\/section>\n
\u4e0b\u8fb9\u8fd9\u7bc7\u6587\u732e\u6ca1\u6709\u4efb\u4f55\u79bb\u5b50\u901a\u9053\uff0c\u4ec5\u5173\u6ce8\u795e\u7ecf\u5143\u63a5\u6536\u4ec0\u4e48\u4fe1\u606f\uff0c\u662f\u5982\u4f55\u8fde\u63a5\u7684\uff0c\u4f46\u662f\u901a\u8fc7\u6539\u8fdb\u6574\u5408\u53d1\u653e\u6a21\u578b\uff0c\u53ef\u4ee5\u4f7f\u8109\u51b2\u5fc3\u6001\u4e0e\u5b9e\u9a8c\u6570\u636e\u975e\u5e38\u63a5\u8fd1[5]\u3002<\/span><\/section>\n

<\/span><\/section>\n

\n
\u5982\u4f55\u9009\u62e9\u6a21\u578b<\/span><\/strong><\/span><\/section>\n

<\/span><\/section>\n<\/h2>\n
\u4ece\u5de6\u5230\u53f3\uff0c\u751f\u7269\u73b0\u5b9e\u6027<\/span>\uff08\u63a5\u8fd1\u771f\u5b9e\u795e\u7ecf\u5143\u7684\u751f\u7406\u7279\u6027\uff09<\/span>\u9010\u6e10\u589e\u52a0\uff0c\u8ba1\u7b97\u590d\u6742\u5ea6\u4e5f\u8d8a\u6765\u8d8a\u5927\u3002\u9009\u62e9\u4ec0\u4e48\u6a21\u578b\u53d6\u51b3\u4e8e\u5173\u5fc3\u95ee\u9898\u7684\u5c3a\u5ea6\uff0c\u5173\u5fc3\u54ea\u65b9\u9762\u7279\u5f81\u3002<\/span><\/section>\n
 <\/span><\/section>\n
<\/section>\n
 <\/span><\/section>\n
\u6700\u65b0\u7814\u7a76\u8868\u660e\uff0c\u73af\u8def\u4e2d\u5982\u679c\u5f15\u5165\u79bb\u5b50\u7535\u6d41\uff0c\u4f1a\u4f7f\u73af\u8def\u5448\u73b0\u7684\u8109\u51b2\u6fc0\u53d1\u7279\u6027\u66f4\u63a5\u8fd1\u5b9e\u9a8c\u89c2\u6d4b\uff0c\u8bf4\u660e\u79bb\u5b50\u7535\u6d41\u5bf9\u4e8e\u5927\u8111\u5de5\u4f5c\u673a\u5236\u5341\u5206\u91cd\u8981\uff0chttps:\/\/www.youtube.com\/watch?v=O1_0KzVTEgE\u3002<\/span><\/section>\n

<\/span><\/section>\n

\n

<\/section>\n<\/h1>\n

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\n
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\n
\n

<\/section>\n

<\/section>\n
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<\/svg><\/section>\n<\/section>\n<\/section>\n
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3. \u795e\u7ecf\u5143\u8ba1\u7b97\u7279\u6027<\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n

<\/section>\n
\u795e\u7ecf\u5143\u7684\u5206\u7c7b\u65e0\u552f\u4e00\u6807\u51c6\uff0c\u4f8b\u5982\u53ef\u5206\u4e3a\u5174\u594b\u6027\u3001\u6291\u5236\u6027\uff0c\u9759\u606f\u6001\u548c\u81ea\u53d1\u6fc0\u53d1\u6001\u7b49\u3002\u6839\u636e\u795e\u7ecf\u5143\u53d1\u653e\u8109\u51b2\u540e\uff0c\u8109\u51b2\u9891\u7387\u548c\u7535\u6d41\u66f2\u7ebf\u662f\u5426\u8fde\u7eed\u53ef\u5c06\u795e\u7ecf\u5143\u5206\u4e3aType I\u548cType II\u3002\u5982\u679c\u66f2\u7ebf\u8fde\u7eed\u5219\u4e3aType I\uff0c\u4e0d\u8fde\u7eed\u5219\u4e3aType II\u3002\u5bf9\u4e8eType II, \u5f53\u7535\u538b\u4f4e\u4e8e\u8109\u51b2\u9608\u503c\u65f6\uff0c\u4f1a\u5448\u73b0\u51fa\u5171\u632f\/\u632f\u8361\u6548\u679c\uff0c\u7531\u4e8eType I\u7684\u8fde\u7eed\u7279\u6027\uff0c\u8fd9\u7c7b\u795e\u7ecf\u5143\u53ef\u4ee5\u6709\u6548\u5730\u7f16\u7801\u8f93\u5165\u4fe1\u53f7\u7684\u5f3a\u5ea6[6]\u3002<\/span><\/section>\n
 <\/span><\/section>\n
[\u76f8\u4f4d\u53cd\u5e94\u66f2\u7ebf](http:\/\/www.scholarpedia.org\/article\/Phase_response_curve)<\/span>\u7684\u5b9a\u4e49\uff1a\u5728\u80fd\u591f\u4ea7\u751f\u89c4\u5219\u8109\u51b2\u7684\u795e\u7ecf\u5143\u4e2d\uff0c\u4e8e\u4e24\u4e2a\u76f8\u90bb\u8109\u51b2\u95f4\u4e0d\u540c\u65f6\u95f4\u70b9\u65bd\u52a0\u5fae\u5f31\u7684\u523a\u6fc0\uff0c\u4e0b\u4e00\u4e2a\u8109\u51b2\u7684\u65f6\u95f4\u4f1a\u88ab\u5982\u4f55\u6539\u53d8\uff0c\u63d0\u524d\u8fd8\u662f\u5ef6\u540e\uff0c\u603b\u662f\u63d0\u524d\u5219\u4e3aType I\u3002\u5982\u679c\u523a\u6fc0\u4f4d\u4e8e\u76f8\u4f4d\u665a\u671f\u8109\u51b2\u88ab\u63d0\u524d\uff0c\u4e8e\u65e9\u671f\u8109\u51b2\u88ab\u5ef6\u8fdf\uff0c\u8fd9\u7c7b\u795e\u7ecf\u5143\u5219\u4e3aType II\u795e\u7ecf\u5143\u3002<\/span><\/section>\n
 <\/span><\/section>\n
<\/section>\n
 <\/span><\/section>\n

\n

<\/section>\n<\/h1>\n

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<\/section>\n

<\/section>\n
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<\/svg><\/section>\n<\/section>\n<\/section>\n
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4. \u795e\u7ecf\u5143\u76f8\u5173\u7814\u7a76\u8fdb\u5c55<\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n

<\/section>\n

\n
\u4e0e\u9002\u65f6\u72b6\u6001\u76f8\u5173\u8bef\u5dee\u5b66\u4e60<\/span><\/strong><\/span><\/section>\n

<\/span><\/section>\n<\/h2>\n
\u5c0f\u8111\u4e2d\u7684\u6d66\u80af\u91ce\u7ec6\u80de\u662f\u5c0f\u8111\u76ae\u8d28\u7684\u552f\u4e00\u8f93\u51fa\uff0c\u8fd0\u52a8\u611f\u5b98\u4fe1\u606f\u7ecf\u8fc7\u82d4\u85d3\u7ea4\u7ef4\u4f20\u5165\uff0c\u518d\u7ecf\u8fc7\u5e73\u884c\u7ea4\u7ef4\u4f20\u9012\u7ed9\u6d66\u80af\u91ce\u7ec6\u80de\u7684\u6811\u7a81\uff0c\u5c0f\u8111\u8f93\u51fa\u7684\u8fd0\u52a8\u72b6\u6001\u4fe1\u606f\u4e0e\u5927\u8111\u9884\u671f\u4e0d\u4e00\u81f4\u65f6\uff0c\u901a\u8fc7\u722c\u884c\u7ea4\u7ef4\u4f20\u5165\u8bef\u5dee\u5b66\u4e60\u4fe1\u53f7\uff0c\u8fdb\u800c\u6539\u53d8\u5e73\u884c\u7ea4\u7ef4\u4e0e\u6d66\u80af\u91ce\u7ec6\u80de\u7684\u7a81\u89e6\u8fde\u63a5\u5f3a\u5ea6\u6765\u5b9e\u73b0\u5c0f\u8111\u5b66\u4e60\u3002<\/span><\/section>\n
 <\/span><\/section>\n
<\/section>\n
 <\/span><\/section>\n
\u8fc7\u53bb\u5927\u5bb6\u8ba4\u4e3a\u722c\u884c\u7ea4\u7ef4\u7ed9\u6d66\u80af\u91ce\u7ec6\u80de\u63d0\u4f9b\u4e8c\u8fdb\u5236\u7684\u8bef\u5dee\u5b66\u4e60\u4fe1\u53f7\uff0c\u8fd9\u79cd\u5047\u8bbe\u4f3c\u4e4e\u8868\u660e\u5c0f\u8111\u5b66\u4e60\u6548\u7387\u7684\u4f4e\u4e0b[7-8]\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u7531\u4e8e\u5b9e\u9a8c\u6280\u672f\u7684\u9650\u5236\uff0c\u901a\u8fc7\u5b9e\u9a8c\u624b\u6bb5\u5f88\u96be\u7cfb\u7edf\u7814\u7a76\u8fd9\u4e2a\u95ee\u9898\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\uff0c\u9700\u8981\u80fd\u6574\u5408\u5927\u91cf\u5b9e\u9a8c\u6570\u636e\u7684\u65b0\u6a21\u578b\u3002\u8ba1\u7b97\u751f\u7269\u5b66\u9886\u57df\u5e38\u89c1\u7684\u65b9\u6cd5\u662f\u5728\u5927\u91cf\u7ec6\u80de\u4e2d\u6536\u96c6\u4e0d\u540c\u79bb\u5b50\u7535\u6d41\u7279\u6027\u7684\u6570\u636e\uff0c\u8fdb\u884c\u5e73\u5747\u5904\u7406\uff0c\u7136\u540e\u518d\u7528\u8fd9\u4e9b\u62e5\u6709\u5747\u503c\u7279\u6027\u7684\u79bb\u5b50\u7535\u6d41\u6784\u5efa\u6a21\u578b\uff0c\u53bb\u6a21\u62df\u5e73\u5747\u5316\u4e4b\u540e\u7684\u6a21\u578b\u8f93\u51fa\u4fe1\u53f7\u3002\u4f46\u662f\u8fd9\u79cd\u5e73\u5747\u5904\u7406\u7684\u65b9\u6cd5\u4ece\u539f\u7406\u4e0a\u662f\u9519\u8bef\u7684\uff0c\u5e76\u4e0d\u80fd\u603b\u662f\u83b7\u5f97\u6ee1\u610f\u7684\u6a21\u578b\uff0c\u4ee5\u6d66\u80af\u91ce\u7ec6\u80de\u4e3a\u4f8b\uff0c\u4e4b\u524d\u5341\u4f59\u5e74Erik De Schutter\u5c0f\u7ec4\u4e00\u76f4\u65e0\u6cd5\u5f97\u5230\u6ee1\u610f\u7684\u6a21\u578b\u3002\u81e7\u8001\u5e08\u81ea\u5df1\u7684\u6a21\u578b\u653e\u677e\u4e86\u6bcf\u4e2a\u53c2\u6570\u7684\u7ea6\u675f\uff0c\u867d\u7136\u91c7\u7528\u4e86\u5e73\u5747\u5904\u7406\u7684\u7406\u5ff5\uff0c\u4f46\u53ea\u8981\u53c2\u6570\u503c\u5728\u6d4b\u91cf\u7684\u8303\u56f4\u4e4b\u5185\u5c31\u53ef\u4ee5\uff0c\u8fd9\u6837\u5c31\u5f97\u5230\u4e86\u57fa\u4e8eCompartment\u7684\u65b0\u6d66\u80af\u91ce\u7ec6\u80de\u6a21\u578b[9]\u3002<\/span><\/section>\n
  <\/span><\/section>\n
\u722c\u884c\u7ea4\u7ef4\u5728\u6d66\u80af\u91ce\u7ec6\u80de\u4e2d\u7684\u6811\u7a81\u54cd\u5e94\u4e0e\u6d66\u80af\u91ce\u7ec6\u80de\u7684\u5174\u594b\u72b6\u6001\u76f8\u5173\u3002\u4ee5\u6d66\u80af\u91ce\u7ec6\u80de\u7684\u6811\u7a81\u54cd\u5e94\u4e3a\u4f8b\uff0c\u5728\u7535\u52bf\u6c34\u5e73\u8f83\u4f4e\u7684\u65f6\u5019\uff0c\u8fd9\u4e2a\u5174\u594b\u4ec5\u4ec5\u5c40\u9650\u5728\u6811\u7a81\u4e3b\u5e72\u4ee5\u53ca\u79bb\u80de\u4f53\u6bd4\u8f83\u8fd1\u7684\u533a\u57df\u3002\u968f\u7740\u5174\u594b\u72b6\u6001\u7684\u63d0\u9ad8\uff0c\u6811\u7a81\u54cd\u5e94\u9010\u6e10\u6269\u6563\u5230\u6574\u4e2a\u6811\u7a81\uff0c\u8fd9\u4e2a\u8fc7\u7a0b\u7684\u673a\u5236\u89e3\u91ca\u5982\u4e0b\uff1a<\/span><\/section>\n
 <\/span><\/section>\n
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\u7b80\u5355\u603b\u7ed3\uff1a\u722c\u884c\u7ea4\u7ef4\u5728\u6d66\u80af\u91ce\u7ec6\u80de\u4e2d\u7684\u54cd\u5e94\u80fd\u591f\u6839\u636e\u8be5\u7ec6\u80de\u7684\u5b9e\u65f6\u5174\u594b\u72b6\u6001\u4ea7\u751f\u4e00\u4e2a\u6a21\u62df\u4fe1\u53f7\u800c\u4e0d\u662f\u4e8c\u8fdb\u5236\u7684\u6709\u6216\u65e0\u4fe1\u53f7\u3002<\/span><\/section>\n
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\u795e\u7ecf\u5143\u591a\u8def\u590d\u7528\u7f16\u7801<\/span><\/strong><\/span><\/section>\n

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A-B\u56fe\u66f2\u7ebf\u4e0d\u540c\u989c\u8272\u4ee3\u8868\u7740\u6291\u5236\u5f3a\u5ea6\uff0c\u5f53\u6291\u5236\u4fe1\u53f7\u9010\u6e10\u589e\u5f3a\uff0c\u6811\u7a81\u8109\u51b2\u7684\u9608\u503c\u88ab\u660e\u663e\u63d0\u9ad8\uff0c\u76f8\u5f53\u4e8e\u8f93\u5165\u8f93\u51fa\u66f2\u7ebf\u6574\u4f53\u53f3\u79fb\u3002\u7531\u6b64\u53ef\u89c1\uff0c\u6291\u5236\u6027\u795e\u7ecf\u5143\u53ef\u4ee5\u52a8\u6001\u8c03\u6574\u7ebf\u6027\u7f16\u7801\u548c\u6811\u7a81\u7f16\u7801\u7684\u7f16\u7801\u8303\u56f4[12]\u3002<\/span><\/section>\n
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\u524d\u5411\u6291\u5236\u56de\u8def\u5b58\u5728\u7740\u53e6\u5916\u4e00\u79cd\u60c5\u5f62\uff0c\u6291\u5236\u6027\u795e\u7ecf\u5143\u662f\u88ab\u53e6\u5916\u4e00\u6279\u5e73\u884c\u7ea4\u7ef4\u6fc0\u6d3b\uff0c\u4e5f\u5c31\u662f\u8fd9\u6279\u5e73\u884c\u7ea4\u7ef4\u5e76\u4e0d\u76f4\u63a5\u4e0e\u88ab\u6291\u5236\u7684\u6d66\u80af\u91ce\u7ec6\u80de\u8fde\u63a5\u3002\u7b2c\u4e00\u79cd\u6a21\u5f0f\u4e2d\uff0c\u6291\u5236\u6027\u8f93\u5165\u5927\u7ea6\u53d1\u751f\u5728\u523a\u6fc0\u8f93\u5165\u76841.4\u6beb\u79d2\u4e4b\u540e\uff0c\u7ecf\u5178\u7684\u5174\u594b-\u6291\u5236\u5ef6\u8fdf\u3002\u800c\u5728\u7b2c\u4e8c\u79cd\u6a21\u5f0f\u4e0b\uff0c\u6291\u5236\u548c\u5174\u594b\u7684\u76f8\u5bf9\u65f6\u95f4\u5219\u53ef\u4ee5\u6709\u4e0d\u540c\u7684\u914d\u7f6e\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u6291\u5236\u53d1\u751f\u65f6\u95f4\u70b9\u5bf9\u6291\u5236\u6548\u679c\u7684\u5f71\u54cd\uff1a\u7814\u7a76\u53d1\u73b0\u5f53\u6291\u5236\u53d1\u751f\u5728\u5174\u594b\u523a\u6fc0\u4e4b\u524d\u5bf9\u8109\u51b2\u6811\u7a81\u7684\u6291\u5236\u6027\u6548\u679c\u662f\u6700\u6709\u6548\u7684\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u5f53\u795e\u7ecf\u5143\u63a5\u53d7\u6765\u81ea\u6291\u5236\u6027\u795e\u7ecf\u5143\u56fa\u5b9a\u5f3a\u5ea6<\/span>\uff088\u4e2a\uff09<\/span>\u7684\u6291\u5236\u65f6\uff0c\u5982\u679c\u6291\u5236\u53d1\u751f\u5728\u5174\u594b\u523a\u6fc0\u4e4b\u524d\u76844.5\u6beb\u79d2\uff0c\u6811\u7a81\u8109\u51b2\u9608\u503c\u589e\u52a0\u5230\u9700\u8981\u6fc0\u6d3b60\u4e2a\u7a81\u89e6\uff0c\u4f46\u662f\u6291\u5236\u53d1\u751f\u5728\u523a\u6fc0\u4e4b\u540e\uff0c\u6291\u5236\u6548\u679c\u5219\u9010\u6e10\u51cf\u5f31\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u4e0a\u8ff0\u6d66\u80af\u91ce\u7ec6\u80de\u5bf9\u8f93\u5165\u8f93\u51fa\u4fe1\u53f7\u7684\u7f16\u7801\u8ba1\u7b97\u5747\u662f\u53d1\u751f\u5728\u6811\u7a81\u5c40\u90e8\u7684\u4e00\u4e2a\u8ba1\u7b97\uff0c\u4e0b\u9762\u4ecb\u7ecd\u6d66\u80af\u91ce\u7ec6\u80de\u7684\u80de\u4f53\u5982\u4f55\u5bf9\u5e73\u884c\u7ea4\u7ef4\u7684\u8f93\u5165\u4fe1\u53f7\u8fdb\u884c\u5904\u7406\u5e76\u4f20\u9012\u7ed9\u4e0b\u4e00\u7ea7\u795e\u7ecf\u5143\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u901a\u8fc7\u6539\u53d8\u80cc\u666f\u566a\u58f0\u4ee5\u53ca\u7a81\u89e6\u6fc0\u6d3b\u4f4d\u7f6e\uff0c\u8fd9\u91cc\u8fdb\u884c\u4e86\u5927\u89c4\u6a21\u4eff\u771f\u3002\u5bf9\u6bcf\u4e00\u4e2a\u5e73\u884c\u7ea4\u7ef4\u8f93\u5165\u4fe1\u53f7\u7684\u5f3a\u5ea6\u4eff\u771f\u4e86500\u6b21<\/span>\uff08trial\uff09<\/span>\uff0c\u83b7\u5f97\u4e86\u4e00\u4e2a\u5e73\u5747\u8109\u51b2\u8f93\u51fa\uff0c\u8be5\u534f\u8bae\u63a5\u8fd1\u4e8e\u4eba\u4f53\u5c0f\u8111\u4e2d\u5b58\u5728\u566a\u58f0\u60c5\u51b5\u4e0b\u7684\u751f\u7406\u8f93\u51fa\u3002\u53d1\u73b0\u5728\u8f93\u5165\u4fe1\u53f7\u8f83\u5f31\u7684\u60c5\u51b5\u4e0b\uff0c\u6811\u7a81\u54cd\u5e94\u4fe1\u53f7\u968f\u7740\u8f93\u5165\u4fe1\u53f7\u7684\u589e\u52a0\u800c\u9010\u6e10\u589e\u5f3a\uff0c\u4e0e\u4e4b\u76f8\u5e94\u7684\u80de\u4f53\u8109\u51b2\u8f93\u51fa\u4fe1\u53f7\u5219\u4f1a\u66f4\u52a0\u9760\u8fd1\u523a\u6fc0\u4fe1\u53f7\uff0c\u589e\u52a0\u80de\u4f53\u8109\u51b2\u8f93\u51fa\u7684\u77ac\u95f4\u9891\u7387\uff0c\u5f62\u6210\u4e00\u4e2aburst\u3002\u5f53\u8f93\u5165\u4fe1\u53f7\u5f3a\u5ea6\u589e\u52a0\u5230\u4e00\u5b9a\u7a0b\u5ea6\u4e4b\u540e<\/span>\uff08\u6bd4\u598250\u4e2a\u7a81\u89e6\uff09<\/span>\uff0c\u5c31\u53ef\u4ee5\u5728\u67d0\u4e9bTrial\u4e2d\u6fc0\u53d1\u51fa\u6811\u7a81\u8109\u51b2\u3002\u6811\u7a81\u8109\u51b2\u6fc0\u53d1\u4e4b\u540e\uff0c\u5728\u5f62\u6210burst\u7684\u540c\u65f6\u4f1a\u4f34\u968f\u4e00\u4e2a\u505c\u987f\u4fe1\u53f7\uff0c\u56e0\u4e3a\u8be5\u73b0\u8c61\u5177\u6709\u968f\u673a\u6027\uff0c\u5e76\u4e0d\u80fd\u5728\u6bcf\u4e00\u4e2atrial\u4e2d\u90fd\u7a33\u5b9a\u89c2\u6d4b\u5230\uff0c\u6240\u4ee5\u5728\u80de\u4f53\u8109\u51b2\u5e73\u5747\u8f93\u51fa\u9891\u7387\u4e2d\u5e76\u4e0d\u660e\u663e\u3002\u5f53\u589e\u52a0\u8f93\u5165\u4fe1\u53f7\u5f3a\u5ea6\u5230\u6fc0\u6d3b70\u4e2a\u7a81\u89e6\u540e\uff0c\u6211\u4eec\u80fd\u591f\u5728\u6bcf\u4e00\u4e2atrial\u91cc\u90fd\u7a33\u5b9a\u6fc0\u53d1\u51fa\u6811\u7a81\u8109\u51b2\uff0c\u8fdb\u800c\u89c2\u6d4b\u5230\u7a33\u5b9a\u7684\u505c\u987f\u4fe1\u53f7\u3002\u56e0\u6b64\u795e\u7ecf\u5143\u53ef\u4ee5\u901a\u8fc7burst-pause\u4fe1\u53f7\u5bf9\u8f93\u5165\u4fe1\u53f7\u8fdb\u884c\u7f16\u7801\u3002<\/span><\/section>\n
 <\/span><\/section>\n
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 <\/span><\/section>\n
\u7b80\u5355\u603b\u7ed3\uff0c\u795e\u7ecf\u5143\u662f\u4ee5\u5355\u4e2a\u6811\u7a81\u5206\u652f\u4e3a\u8ba1\u7b97\u5355\u5143\u5b9e\u73b0\u795e\u7ecf\u5143\u7684\u591a\u8def\u590d\u7528\u4ee3\u7801\u3002<\/span><\/section>\n

<\/span><\/section>\n

\n
\u795e\u7ecf\u5143\u529f\u80fd\u96c6\u7fa4\u52a8\u6001\u5f62\u6210<\/span><\/strong><\/span><\/section>\n

<\/span><\/section>\n<\/h2>\n
\u6d66\u80af\u91ce\u7ec6\u80de\u7684\u76f8\u4f4d\u53cd\u5e94\u66f2\u7ebf\u975e\u5e38\u7279\u522b\uff0c\u5f53\u8109\u51b2\u9891\u7387\u8f83\u4f4e\u65f6\u76f8\u4f4d\u53cd\u5e94\u66f2\u7ebf\u51e0\u4e4e\u662f\u5e73\u7684\uff0c\u4e14\u63a5\u8fd10\uff0c\u968f\u7740\u8109\u51b2\u9891\u7387\u589e\u52a0\u5728\u76f8\u4f4d\u672b\u671f\u9010\u6e10\u51fa\u73b0\u4e00\u4e2aPeak\u5cf0\uff0c\u5f53\u8109\u51b2\u9891\u7387\u5347\u9ad8\u7684\u540c\u65f6\uff0c\u8fd9\u4e2a\u5cf0\u4e5f\u4f1a\u53d8\u9ad8\u548c\u53d8\u5bbd\u3002<\/span><\/section>\n
 <\/span><\/section>\n
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 <\/span><\/section>\n
\u81e7\u8001\u5e08\u89e3\u91ca\uff1a\u5728\u8109\u51b2\u95f4\u671f\u65e9\u671f\uff0c\u7535\u52bf\u6c34\u5e73\u4f4e\uff0c\u79bb\u94a0\u7535\u6d41\u6fc0\u53d1\u9608\u503c\u8f83\u8fdc\uff0c\u5fae\u5f31\u7684\u6b63\u523a\u6fc0\u4e0d\u4f1a\u6fc0\u53d1\u94a0\u7535\u6d41\uff0c\u7136\u800c\u5728\u8109\u51b2\u95f4\u671f\u7684\u540e\u534a\u6bb5\u7535\u52bf\u6c34\u5e73\u8f83\u9ad8\u66f4\u63a5\u8fd1\u94a0\u7535\u6d41\u6fc0\u6d3b\u9608\u503c\u3002\u8fd9\u65f6\u7ed9\u4e00\u4e2a\u6b63\u523a\u6fc0\u4f1a\u6fc0\u6d3b\u94a0\u7535\u6d41\u4ece\u800c\u52a0\u901f\u4e0b\u4e00\u4e2a\u8109\u51b2\u7684\u6fc0\u53d1\uff0c\u8fd9\u5c31\u662f\u5728\u76f8\u4f4d\u53cd\u5e94\u66f2\u7ebf\u672b\u7aef\u51fa\u5cf0\u7684\u539f\u56e0\u3002<\/span><\/section>\n
 <\/span><\/section>\n
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 <\/span><\/section>\n
\u795e\u7ecf\u5143\u8109\u51b2\u9891\u7387\u8f83\u9ad8\u65f6\uff0c\u8109\u51b2\u95f4\u671f\u7684\u6574\u4f53\u7535\u52bf\u6c34\u5e73\u6bd4\u8f83\u9ad8\uff0c\u4f1a\u66f4\u65e9\u5730\u5230\u8fbe\u7535\u6d41\u7684\u6fc0\u53d1\u9608\u503c\uff0c\u5efa\u6a21\u548c\u5b9e\u9a8c\u7ed3\u679c\u53ef\u4ee5\u4e92\u76f8\u9a8c\u8bc1\u3002\u4e0b\u9762\u8981\u63a2\u7d22\u8fd9\u4e00\u53d1\u73b0\u7684\u529f\u80fd\u610f\u4e49[13]\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u6d66\u80af\u91ce\u7ec6\u80de\u5728\u5c0f\u8111\u56de\u8def\u4e2d\u80fd\u591f\u901a\u8fc7\u8f74\u7a81\u5206\u652f<\/span> (axon collaterals)<\/span> \u5efa\u7acb\u6291\u5236\u6027\u8fde\u63a5\u3002\u6839\u636e\u8fd9\u4e00\u73b0\u8c61\u6784\u5efa\u4e86\u4e00\u4e2a\u73af\u8def\u6a21\u578b\u5e76\u7814\u7a76\u53d1\u73b0\uff1a\u8fd9\u4e2a\u73af\u8def\u80fd\u591f\u4ea7\u751f\u4e00\u4e2a\u4e0e\u5355\u795e\u7ecf\u5143\u8109\u51b2\u9891\u7387\u65e0\u5173\u7684\u9ad8\u9891\u632f\u8361\u3002\u5206\u6790\u6bcf\u4e00\u4e2a\u795e\u7ecf\u5143\u7684\u8109\u51b2\u6fc0\u53d1\u65f6\u523b\u4f1a\u53d1\u73b0\u4e0d\u540c\u795e\u7ecf\u5143\u7684\u6fc0\u53d1\u65f6\u523b\u96c6\u4e2d\u5728\u5927\u7ea6\u95f4\u8ddd\u4e3a6\u6beb\u79d2\u7684Cluster\u91cc\uff0c\u5b83\u4e0d\u662f\u4e25\u683c\u610f\u4e49\u4e0a\u7684Spike-to-Spike\u540c\u6b65\uff0c\u800c\u662f\u96c6\u4e2d\u5728\u4e00\u4e2aCluster\u91cc\u7684\u5f31\u540c\u6b65\u3002\u73af\u8def\u632f\u8361\u7684\u9891\u7387\u662f1000\/6\u5927\u7ea6\u5728160\u8d6b\u5179\u7684\u6c34\u5e73\uff0c\u53ef\u662f\u5355\u4e2a\u795e\u7ecf\u5143\u7684\u8109\u51b2\u9891\u7387\u662f116\u8d6b\u5179\u3002\u6240\u4ee5\u8fd9\u4e2a\u73af\u8def\u53ef\u4ee5\u4ea7\u751f\u4e0e\u5355\u4e2a\u795e\u7ecf\u5143\u8109\u51b2\u9891\u7387\u65e0\u5173\u7684\u4e00\u4e2a\u9ad8\u9891\u632f\u8361\uff0c\u800c\u4e14\u5176\u9707\u8361\u5f3a\u5ea6\u968f\u7740\u5355\u4e2a\u795e\u7ecf\u5143\u8109\u51b2\u9891\u7387\u7684\u964d\u4f4e\u9010\u6e10\u51cf\u5f31\u3002\u5728\u5355\u4e2a\u795e\u7ecf\u5143\u7684\u8109\u51b2\u9891\u7387\u964d\u4f4e\u523010\u8d6b\u5179\u7684\u65f6\u5019\uff0c\u8fd9\u4e2a\u7f51\u7edc\u4e0d\u4f1a\u4ea7\u751f\u4efb\u4f55\u9ad8\u9891\u632f\u8361\u3002<\/span><\/section>\n
 <\/span><\/section>\n
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 <\/span><\/section>\n
\u6240\u6709\u4e0e\u8109\u51b2\u9891\u7387\u76f8\u5173\u7684\u632f\u52a8\u5f3a\u5ea6\u6216\u8109\u51b2\u540c\u6b65\u6027\u7684\u53d8\u5316\u4e5f\u90fd\u53ef\u4ee5\u53cd\u6620\u5728\u795e\u7ecf\u5143\u95f4\u8109\u51b2\u6fc0\u53d1\u65f6\u523b\u7684\u4e92\u76f8\u5173\u7cfb\u6570\u4e2d\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u4f46\u662f\uff0c\u76ee\u524d\u7684\u7814\u7a76\u65e0\u6cd5\u4ece\u903b\u8f91\u4e0a\u533a\u5206\u51fa\u4e0e\u8109\u51b2\u9891\u7387\u76f8\u5173\u7684\u9ad8\u9891\u632f\u8361\u5f3a\u5ea6\u662f\u7531\u4e8e\u8109\u51b2\u9891\u7387\u53d8\u5316\u76f4\u63a5\u5bfc\u81f4\u7684\uff0c\u8fd8\u662f\u4e0e\u8109\u51b2\u9891\u7387\u76f8\u5173\u7684\u76f8\u4f4d\u53cd\u5e94\u66f2\u7ebf\u53d8\u5316\u6240\u5bfc\u81f4\u3002\u56e0\u4e3a\uff0c\u524d\u4eba\u7814\u7a76<\/span>\uff082007\uff09<\/span>\u8868\u660e\uff0c\u795e\u7ecf\u5143\u4e4b\u95f4\u8109\u51b2\u8f93\u51fa\u540c\u6b65\u6027\u53ef\u4ee5\u5355\u7eaf\u968f\u7740\u795e\u7ecf\u5143\u8109\u51b2\u8f93\u51fa\u9891\u7387\u7684\u589e\u52a0\u800c\u589e\u5f3a\uff0c\u81e7\u8001\u5e08\u8981\u8bc1\u660e\u4ed6\u53d1\u73b0\u7684\u73b0\u8c61\u4e0e\u4e0a\u8ff0\u73b0\u8c61\u662f\u540c\u4e00\u4e2a\u673a\u5236\u8fd8\u662f\u53e6\u6709\u539f\u56e0[14-15]\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u5229\u7528Kuramoto\u632f\u8361\u5b50\u6a21\u578b\uff0c\u8be5\u6a21\u578b\u6ca1\u6709\u6d89\u53ca\u4efb\u4f55\u8109\u51b2\u9891\u7387\u7684\u6982\u5ff5\uff0c\u9996\u5148\u8bc1\u660e\u4e86\u4ece\u56e0\u679c\u5173\u7cfb\u4e0a\uff0c\u9ad8\u9891\u632f\u8361\u5f3a\u5ea6\u7684\u6539\u53d8\u4e0e\u76f8\u4f4d\u53cd\u5e94\u66f2\u7ebf\u53d8\u5316\u4e4b\u95f4\u5b58\u5728\u56e0\u679c\u8054\u7cfb\u3002\u795e\u7ecf\u5143\u4e4b\u95f4\u8109\u51b2\u8f93\u51fa\u7684\u540c\u6b65\u6027\u968f\u7740\u8109\u51b2\u9891\u7387\u7684\u6539\u53d8\u7684\u8d8b\u52bf\u4e0e\u4e4b\u524d2007\u5e74\u7684\u7ed3\u679c\u4e0d\u540c\u3002<\/span><\/section>\n
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\u4e4b\u524d\u7684\u4eff\u771f\u7ed3\u679c\u90fd\u662f\u5728\u795e\u7ecf\u5143\u8fbe\u5230\u7a33\u6001\u8109\u51b2\u9891\u7387\u7684\u60c5\u51b5\u4e0b\u53d6\u5f97\uff0c\u4f46\u662f\u8fd9\u4e00\u7279\u6027\u5982\u679c\u5728\u529f\u80fd\u4e0a\u80fd\u53d1\u6325\u91cd\u8981\u7684\u529f\u80fd\u4f5c\u7528\uff0c\u8109\u51b2\u540c\u6b65\u6027\u9700\u8981\u968f\u7740\u795e\u7ecf\u5143\u7684\u8109\u51b2\u9891\u7387\u52a8\u6001\u53d1\u751f\u6539\u53d8\u3002\u901a\u8fc7\u6a21\u578b\u4eff\u771f\u53d1\u73b0\u73af\u8def\u8109\u51b2\u8f93\u51fa\u540c\u6b65\u6027\u53ef\u4ee5\u5b9e\u73b0\u77ac\u95f4\u6539\u53d8\uff0c\u6a21\u578b\u8f93\u51fa\u540c\u6b65\u6027\u4f1a\u7d27\u8ddf\u8109\u51b2\u9891\u7387\u6539\u53d8\u7684\u8f68\u8ff9\u3002\u800c\u4e14\u6a21\u578b\u4e2d\u5b58\u5728\u90e8\u5206\u5f02\u8d28\uff08\u8109\u51b2\u9891\u7387\u964d\u4f4e\uff09\u795e\u7ecf\u5143\uff0c\u4e5f\u4e0d\u4f1a\u660e\u663e\u964d\u4f4e\u6a21\u578b\u8f93\u51fa\u540c\u6b65\u6027\u3002<\/span><\/section>\n
 <\/span><\/section>\n
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\u603b\u7ed3\uff1a\u9996\u6b21\u4ece\u7406\u8bba\u4e0a\u91cd\u590d\u51fa\u4e0e\u8109\u51b2\u9891\u7387\u76f8\u5173\u7684\u76f8\u4f4d\u53cd\u5e94\u66f2\u7ebf\u53d8\u5316\u7279\u6027\uff0c\u89e3\u91ca\u4e86\u8109\u51b2\u53cd\u5e94\u66f2\u7ebf\u7279\u6027\u7684\u4ea7\u751f\u673a\u5236\uff0c\u901a\u8fc7\u73af\u8def\u4eff\u771f\uff0c\u63d0\u51fa\u4e86\u4e00\u79cd\u795e\u7ecf\u5143\u529f\u80fd\u96c6\u7fa4\u52a8\u6001\u5f62\u6210\u65b0\u7406\u8bba\u3002<\/span><\/section>\n

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\u4e2a\u4f53\u5dee\u5f02\u6027\u4e0e\u7a33\u6001\u53ef\u5851\u6027<\/span><\/strong><\/span><\/section>\n

<\/span><\/section>\n<\/h2>\n
\u56fe\u4e2d\u795e\u7ecf\u51431\u548c2\u6709\u7740\u975e\u5e38\u7c7b\u4f3c\u7684\u6fc0\u53d1\u6a21\u5f0f\uff0c\u4e5f\u5c31\u662f\u52a8\u4f5c\u7535\u4f4d\u7279\u6027\u5f88\u63a5\u8fd1\u3002\u4f46\u5982\u679c\u6d4b\u91cf\u4e24\u4e2a\u795e\u7ecf\u5143\u4e2d\u7684\u7535\u6d41\u4f1a\u53d1\u73b0\u6784\u6210\u7535\u6d41\u7684\u5e45\u5ea6\u4e0d\u540c\u3002\u628a\u6570\u636e\u6574\u5408\u8d77\u6765\uff0c\u53d1\u73b0\u540c\u6837\u4e00\u79cd\u7535\u6d41\u4f8b\u5982\u9499\u79bb\u5b50\u7535\u6d41\u5728\u4e0d\u540c\u7684\u7ec6\u80de\u4e2d\u4f1a\u67093~5\u500d\u7684\u53d8\u5316\uff0c\u4f46\u5927\u5bb6\u5bb9\u6613\u5ffd\u89c6\u795e\u7ecf\u5143\u7684\u4e2a\u4f53\u5dee\u5f02\u6027\u8fd9\u4e00\u5ba2\u89c2\u4e8b\u5b9e[16]\u3002<\/span><\/section>\n
 <\/span><\/section>\n
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\u7531\u4e8e\u5b9e\u9a8c\u4e2d\u7535\u5bfc\u6d4b\u91cf\u8bef\u5dee\u8f83\u5927\uff0c\u5f88\u591a\u4eba\u89c9\u5f97\u8fd9\u4e9b\u5dee\u5f02\u662f\u7531\u4e8e\u6d4b\u91cf\u4e0d\u51c6\u786e\u6240\u5bfc\u81f4\u3002\u901a\u8fc7\u5bf9\u8868\u8fbe\u76f8\u5e94\u79bb\u5b50\u901a\u9053\u7684mRNA\u6c34\u5e73\u8fdb\u884c\u6d4b\u91cf\uff0c\u6700\u540e\u7ed3\u679c\u53d1\u73b0\u4e0d\u540c\u7ec6\u80de\u4e2d\u7684mRNA\u542b\u91cf\u5dee\u5f02\u4e5f\u540c\u6837\u5f88\u5927\uff0c\u8fd9\u4e5f\u5c31\u8bc1\u5b9e\u4e86\u5355\u4e2a\u795e\u7ecf\u5143\u4e4b\u95f4\u786e\u5b9e\u5b58\u5728\u4e2a\u4f53\u5dee\u5f02\u6027[17]\u3002<\/span><\/section>\n
 <\/span><\/section>\n
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 <\/span><\/section>\n
\u5982\u679c\u7528\u6c42\u5e73\u5747\u7684\u65b9\u5f0f\u7ea6\u675f\u6a21\u578b\u4e2d\u7684\u79bb\u5b50\u7535\u6d41\u7279\u6027\uff0c\u591a\u6570\u60c5\u51b5\u4e0b\u5e76\u4e0d\u80fd\u83b7\u5f97\u6ee1\u610f\u7684\u6a21\u578b\uff0c\u5373\u4f7f\u5f97\u5230\u4e86\uff0c\u8be5\u6a21\u578b\u4e5f\u4e0d\u9c81\u68d2<\/span>\uff08\u65bd\u52a0\u5f88\u5c0f\u7684\u53c2\u6570\u6539\u53d8\uff0c\u6a21\u578b\u8f93\u51fa\u7279\u6027\u5c31\u4f1a\u6539\u53d8\uff09<\/span>\u3002\u7136\u800c\uff0c\u771f\u5b9e\u7684\u795e\u7ecf\u73af\u8def\u65e0\u65f6\u65e0\u523b\u5730\u4e0d\u5728\u7ecf\u53d7\u6270\u52a8\uff0c\u4ee5\u79bb\u5b50\u901a\u9053\u4e3a\u4f8b\uff0c\u5b83\u4f5c\u4e3a\u86cb\u767d\u8d28\u4f1a\u7ecf\u5386\u51cb\u4ea1\uff0c\u5728\u795e\u7ecf\u5143\u80de\u4f53\u4ea7\u751f\u7684mRNA\u9700\u8981\u8981\u8fd0\u8f93\u5230\u8fdc\u7aef\u8fdb\u884c\u4e00\u4e2a\u5c40\u90e8\u7684\u86cb\u767d\u8d28\u5408\u6210<\/span>\uff08\u6709\u4e89\u8bae\uff09<\/span>\uff0c\u4e0d\u53ef\u80fd\u6bcf\u6b21\u8fd0\u8f93\u90fd\u90a3\u4e48\u7cbe\u786e\u3002\u540c\u65f6\u795e\u7ecf\u7cfb\u7edf\u8fd8\u9762\u4e34\u5404\u79cd\u73af\u5883\u566a\u58f0\uff0c\u6bd4\u5982\u4f53\u6e29\u7684\u6539\u53d8\uff0c\u60c5\u7eea\u7d27\u5f20\u5f15\u8d77\u7684\u795e\u7ecf\u8c03\u8d28\u91ca\u653e\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u5c3d\u7ba1\u540c\u4e00\u79cd\u7c7b\u795e\u7ecf\u5143\u53ef\u4ee5\u8f93\u51fa\u7c7b\u4f3c\u7684\u8109\u51b2\u4fe1\u53f7\uff0c\u4f46\u662f\u795e\u7ecf\u5143\u4e4b\u95f4\u5b58\u5728\u7740\u4e2a\u4f53\u5dee\u5f02\u6027\uff0c\u5373\u7ec4\u6210\u4e2a\u4f53\u795e\u7ecf\u5143\u7684\u5404\u79cd\u79bb\u5b50\u7535\u6d41\u7ec4\u5408\u5343\u5dee\u4e07\u522b\u3002\u4ec0\u4e48\u6837\u7684\u673a\u7406\u53ef\u4ee5\u4fdd\u8bc1\u4e0d\u540c\u4e2a\u4f53\u4e2d\u5404\u79cd\u7535\u6d41\u7535\u5bfc\u503c\u5dee\u5f02\u5f88\u5927\u7684\u60c5\u51b5\u4e0b\uff0c\u4ed6\u4eec\u7ec4\u6210\u7684\u795e\u7ecf\u5143\u80fd\u4ea7\u751f\u7a33\u5b9a\u7684\u8f93\u51fa\uff1f<\/span><\/section>\n
 <\/span><\/section>\n
\u7a33\u6001\u53ef\u5851\u6027\u662f\u4e00\u79cd\u53ef\u80fd\u7684\u751f\u7406\u673a\u5236\uff0c\u5de5\u4f5c\u539f\u7406\u5c31\u662f\u5f15\u5165\u81ea\u52a8\u63a7\u5236\u539f\u7406\u7684\u8d1f\u53cd\u9988\u6982\u5ff5\uff0c\u8bbe\u5b9a\u4e00\u4e2asetpoint\u5b9a\u70b9<\/span>\uff08\u4ee3\u8868\u7cfb\u7edf\u60f3\u8981\u83b7\u5f97\u7684\u4e00\u4e2a\u72b6\u6001\uff09<\/span>\uff0c\u5f53\u7cfb\u7edf\u7684\u8f93\u51fa\u504f\u79bb\u5b9a\u70b9\u65f6\uff0c\u4fbf\u4f1a\u5728\u8bef\u5dee\u7684\u5f15\u5bfc\u4e0b\uff0c\u4fc3\u4f7f\u76f8\u5e94\u79bb\u5b50\u7535\u6d41\u7684\u7535\u5bfc\u503c\u53d1\u751f\u53d8\u5316\uff0c\u6700\u7ec8\u4f7f\u7cfb\u7edf\u8f93\u51fa\u6062\u590d\u5230setpoint\uff0c\u5373\u4ea7\u751f\u76f8\u540c\u7684\u8109\u51b2\u8f93\u51fa\u3002<\/span><\/section>\n
 <\/span><\/section>\n
\u56feA\u548cB\u4e24\u4e2a\u6a21\u578b\u521d\u59cb\u72b6\u6001\u5bf9\u5e94\u7740\u4e0d\u540c\u7684\u79bb\u5b50\u7535\u6d41\u8d77\u70b9\u5e45\u503c\uff0c\u7ecf\u8fc7\u8d1f\u53cd\u9988\u8c03\u8282\u4e4b\u540e\uff0c\u90fd\u53ef\u4ee5\u8fbe\u5230\u76f8\u540c\u7684\u795e\u7ecf\u5143\u8109\u51b2\u8f93\u51fa\u6a21\u5f0f\uff0c\u5373\u4fbf\u7ec8\u70b9\u7684\u79bb\u5b50\u7535\u6d41\u5e45\u503c\u4e5f\u4f9d\u7136\u4e0d\u540c[18-19]\u3002<\/span><\/section>\n
 <\/span><\/section>\n
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\u8fd9\u4e2a\u6a21\u578b\uff0c\u53ef\u4ee5\u62b5\u5fa1\u5404\u79cd\u5e72\u6270\u3002\u6bd4\u5982\u6b63\u5e38\u751f\u7406\u6761\u4ef6\u4e0b\uff0c\u94be\u7535\u6d41\u7684\u9006\u8f6c\u7535\u52bf\u662f-80\u6beb\u4f0f\uff0c\u5982\u679c\u901a\u8fc7\u6539\u53d8\u7ec6\u80de\u5916\u94be\u79bb\u5b50\u6d53\u5ea6\uff0c\u4f7f\u94be\u7535\u6d41\u9006\u8f6c\u7535\u52bf\u5230\u4e0a\u5347\u5230-60\u6beb\u4f0f\uff0c\u8fd9\u4e2a\u6a21\u578b\u4f1a\u6709\u4e00\u4e2a\u77ac\u95f4\u7684\u6539\u53d8\uff0cplateau\u4e0a\u7684\u8109\u51b2\u5168\u90e8\u6d88\u5931\u3002\u7ecf\u8fc7\u4e00\u6bb5\u65f6\u95f4\u4e4b\u540e\uff0c\u867d\u7136\u6062\u590d\u4e86\u539f\u6709\u8109\u51b2\u6ce2\u5f62\u6a21\u5f0f\uff0c\u4f46\u662f\u79bb\u5b50\u7535\u6d41\u7684\u5e45\u503c\u76f8\u5bf9\u4e8e\u539f\u6709\u6a21\u5f0f\u5df2\u7ecf\u5b8c\u5168\u4e0d\u540c\u4e86\u3002<\/span><\/section>\n
 <\/span><\/section>\n
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 <\/span> <\/span><\/section>\n
\u8fd9\u4e2a\u7406\u8bba\u5148\u6709\u6a21\u578b\u9884\u6d4b\uff0c\u7136\u540e\u6709\u4e86\u5b9e\u9a8c\u9a8c\u8bc1\uff0c\u4f5c\u8005\u4eec\u901a\u8fc7\u836f\u7269\u5c06\u795e\u7ecf\u5143\u7684\u8109\u51b2\u8f93\u51fa\u6a21\u5f0f\u4ecebursting\u6539\u53d8\u6210\u4e3atonic spiking\u7684\u6fc0\u53d1\u6a21\u5f0f\u3002\u53ef\u662f77\u5c0f\u65f6\u540e\u6211\u4eec\u53ef\u4ee5\u53d1\u73b0\u795e\u7ecf\u5143\u53c8\u6062\u590d\u4e86\u539f\u6709\u7684\u8109\u51b2\u8f93\u51fa\u6a21\u5f0f\uff0c\u8fdb\u800c\u8bc1\u5b9e\u4e86\u7a33\u6001\u53ef\u5851\u6027\u6a21\u578b\u7684\u673a\u7406[20]\u3002<\/span><\/section>\n
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\u8fc7\u53bb\u7684\u6a21\u578b\u7f3a\u4e4f\u751f\u7269\u5b9e\u73b0\u8fc7\u7a0b\u7684\u63cf\u8ff0\uff0c\u8fd9\u4e2a\u56fe\u4e2d\u6a21\u578b\u6784\u5efa\u4e86\u4eceDNA\u5230RNA\u518d\u5230\u6700\u540e\u86cb\u767d\u8d28\u6574\u4e2a\u751f\u7269\u5408\u6210\u8fc7\u7a0b\u7684\u8d1f\u53cd\u9988\u56de\u8def\uff0c\u5177\u6709\u4e00\u5b9a\u751f\u7269\u73b0\u5b9e\u6027\u3002<\/span><\/section>\n
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\u9499\u79bb\u5b50\u6d53\u5ea6\u4fe1\u53f7\u4f5c\u4e3a\u4fe1\u4f7f\u4ee3\u8868\u795e\u7ecf\u5143\u8f93\u51fa\u7684\u76ee\u6807\u6a21\u5f0f\uff0c\u5982\u679c\u5b9e\u65f6\u9499\u79bb\u5b50\u6d53\u5ea6\u4fe1\u53f7\u4e0e\u6b64\u76ee\u6807\u4fe1\u53f7\u4e0d\u4e00\u81f4\uff0c\u79ef\u7d2f\u8d77\u6765\u7684\u8bef\u5dee\u4fe1\u53f7\u5c31\u4f1a\u9a71\u52a8\u76f8\u5e94\u79bb\u5b50\u7535\u6d41\u53d1\u751f\u6539\u53d8\uff0c\u76f4\u5230\u7cfb\u7edf\u8fbe\u5230\u7a33\u5b9a\u7684setpoint[21]\u3002<\/span><\/section>\n

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\u795e\u7ecf\u8c03\u63a7\u4e0d\u540c\u65b9\u5411<\/span><\/strong><\/span><\/section>\n

<\/span><\/section>\n<\/h2>\n
\u5982\u56fe\u6240\u793a\uff0c\u795e\u7ecf\u5143\u63a5\u6536\u795e\u7ecf\u9012\u8d28\u8c03\u63a7\u65f6\uff0c\u6709\u65f6\u4f1a\u5bf9\u795e\u7ecf\u5143\u7684\u8f93\u51fa\u4ea7\u751f\u5b9a\u6027\u6539\u53d8\uff0c\u6709\u65f6\u5219\u4e0d\u4f1a\u3002\u795e\u7ecf\u8c03\u8d28\u7684\u8c03\u63a7\u5e76\u4e0d\u5177\u6709\u7279\u5f02\u6027\uff0c\u4f1a\u540c\u65f6\u5f71\u54cd\u597d\u51e0\u79cd\u7535\u6d41\u3002\u6bcf\u4e2a\u795e\u7ecf\u5143\u4e2a\u4f53\u53c8\u62e5\u6709\u4e2a\u4f53\u5dee\u5f02\u6027\uff0c\u90a3\u4e48\u63a5\u6536\u5230\u795e\u7ecf\u8c03\u8d28\u540e\uff0c\u4ec0\u4e48\u6837\u7684\u673a\u5236\u53ef\u4ee5\u4f7f\u5177\u6709\u4e2a\u4f53\u5dee\u5f02\u6027\u7684\u795e\u7ecf\u5143\u4ecd\u7136\u7ef4\u6301\u76f8\u4f3c\u7684\u6a21\u578b\u8f93\u51fa\uff1f<\/span><\/section>\n
 <\/span><\/section>\n
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Goldman\u7b49\u4eba\u901a\u8fc7\u641c\u7d22\u795e\u7ecf\u5143\u6a21\u578b\u7684\u4e09\u7ef4\u53c2\u6570\u7a7a\u95f4\uff0c\u53d1\u73b0\u9ec4\u8272\u533a\u95f4\u662fbursting\u7a7a\u95f4\uff0c\u84dd\u8272\u662fsilent\u7a7a\u95f4\uff0c\u800c\u7ea2\u8272\u662ftonic bursting\u7a7a\u95f4\u3002\u5047\u5982\u901a\u8fc7\u795e\u7ecf\u8c03\u8d28\u53bb\u5b9a\u6027\u6539\u53d8\u795e\u7ecf\u5143\u7684\u53d1\u653e\u6a21\u5f0f\uff0c\u5e94\u8be5\u6cbf\u7740\u7eff\u8272\u7bad\u5934\u8fd9\u4e2a\u65b9\u5411\u8ba9\u8c03\u8d28\u53bb\u6539\u53d8\u76f8\u5e94\u7684\u79bb\u5b50\u7535\u6d41\uff1b\u5982\u679c\u4e0d\u60f3\u5b9a\u6027\u5730\u6539\u53d8\u795e\u7ecf\u5143\u7684\u53d1\u653e\u6a21\u5f0f\u800c\u662f\u60f3\u7ef4\u6301\u5f53\u524d\u8109\u51b2\u8f93\u51fa\u7279\u6027\uff0c\u5219\u9700\u8981\u6cbf\u7740\u9ed1\u8272\u7bad\u5934\u7684\u65b9\u5411\u6539\u53d8\uff0c\u5373\u4e0d\u540c\u79cd\u7c7b\u7684\u79bb\u5b50\u7535\u6d41\u901a\u8fc7\u534f\u540c\u4f5c\u7528\u53ef\u4ee5\u4f7f\u795e\u7ecf\u5143\u5728\u63a5\u53d7\u523a\u6fc0\u540e\u4ecd\u7136\u4fdd\u6301\u7a33\u5b9a\u7684\u8109\u51b2\u8f93\u51fa\u7279\u6027[22]\u3002<\/span><\/section>\n
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\u53d1\u73b0\u4e00\uff0c\u5728type II\u7684Connor-Stevens\u6a21\u578b\u4e2d\u5f15\u5165\u4e00\u5b9a\u91cf\u7684\u94be\u7535\u6d41\u53ef\u4ee5\u4f7f\u5176\u4ecetype II\u8f6c\u53d8\u6210type I\uff0c\u4f46\u662f\u5f15\u5165\u8fc7\u91cf\u7684\u94be\u7535\u6d41\u53c8\u4f1a\u4f7f\u5176\u91cd\u65b0\u53d8\u56detype I\u795e\u7ecf\u5143[23]\u3002<\/span><\/section>\n
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\u603b\u7ed3\u8bf4\uff0c\u5728\u4f4e\u7ef4\u60c5\u51b5\u4e0b\u7684\u4e00\u822c\u539f\u5219\u53ef\u80fd\u662f\u9002\u7528\u7684\uff0c\u4f46\u5728\u9ad8\u7ef4\u7a7a\u95f4\u5374\u4e0d\u4e00\u5b9a\u9002\u7528\u3002\u5982\u679c\u60f3\u8981\u5b9e\u73b0\u4e0a\u8ff0\u53d8\u5316\uff0c\u5bf9\u4e8e\u64cd\u4f5c\u5355\u4e2a\u795e\u7ecf\u5143\u53d8\u5316\u800c\u8a00\u53ef\u80fd\u8981\u6c42\u4f1a\u5f88\u9ad8\uff0c\u5982\u4f55\u901a\u8fc7\u7ea6\u675f\u5176\u4ed6\u56e0\u7d20\u589e\u52a0\u6bcf\u4e00\u4e2a\u7ef4\u5ea6\u7684\u7a7a\u95f4\uff0c\u5982\u5728\u9ad8\u7ef4\u7a7a\u95f4\u4e2d\u589e\u52a0\u89e3\u7684\u8303\u56f4\uff0c\u6765\u589e\u52a0\u6a21\u578b\u7684\u9c81\u68d2\u6027\u662f\u8001\u5e08\u6b63\u51c6\u5907\u53d1\u8868\u7684\u4e00\u7bc7\u6587\u7ae0\u3002<\/span><\/section>\n
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\u5728\u6d77\u9a6c\u4f53\u795e\u7ecf\u5143\u4e2d\u5f15\u5165\u4e00\u4e2a\u5149\u654f\u611f\u79bb\u5b50\u901a\u9053\uff0c\u5b9e\u73b0\u4eba\u4e3a\u64cd\u7eb5\u795e\u7ecf\u5143\u8109\u51b2\u53d1\u653e\u7684\u76ee\u7684\uff0c\u4f1a\u53d1\u73b0\u795e\u7ecf\u5143\u8f74\u7a81\u521d\u6bb5\u5728\u7ecf\u5386\u957f\u65f6\u95f4\u7684burst\u8109\u51b2\u6fc0\u53d1\u540e\u4f1a\u9010\u6e10\u5411\u8fdc\u7aef\u79fb\u52a8\u3002\u79fb\u52a8\u7684\u76ee\u7684\u662f\u4e3a\u4e86\u964d\u4f4e\u795e\u7ecf\u5143\u7684\u5174\u594b\u6027<\/span>\uff08\u7406\u8bba\u4e0a\u5b58\u5728\u4e89\u8bae\uff01\uff09<\/span>\uff0c\u53ea\u6709\u964d\u4f4e\u5174\u594b\u654f\u611f\u5ea6\u624d\u80fd\u4f7f\u795e\u7ecf\u5143\u7ef4\u6301\u4e00\u4e2a\u4e0e\u521d\u59cb\u6001\u76f8\u4f3c\u7684\u53d1\u653e\u6a21\u5f0f[23]\u3002<\/span><\/section>\n
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5. \u795e\u7ecf\u5143\u5efa\u6a21\u672a\u6765\u53d1\u5c55\u65b9\u5411<\/span><\/strong><\/strong><\/p>\n<\/section>\n

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\u901a\u8fc7Compartment\u6a21\u578b\u505a\u5927\u89c4\u6a21\u7684\u73af\u8def\u4eff\u771f\u662f\u6bd4\u8f83\u56f0\u96be\u7684\uff0c\u8ba1\u7b97\u7684\u53d8\u91cf\u975e\u5e38\u591a\u975e\u5e38\u590d\u6742\uff0c\u5bf9\u7b97\u529b\u8981\u6c42\u6781\u9ad8\uff01\u8bf8\u5982Allen Brain Institute\uff0cStanford University\uff0cBlue Brain Project\u7b49\u80cc\u9760\u5927\u5e73\u53f0\u7684\u4e00\u4e9b\u7814\u7a76\u8005\u6709\u5728\u5f00\u5c55\u76f8\u5173\u7814\u7a76\u3002\u4f46\u662f\u4e5f\u4e0d\u80fd\u65e0\u9650\u5236\u7684\u589e\u52a0\u6a21\u578b\u53c2\u6570\uff0c\u4e00\u4e2a\u53ef\u884c\u7684\u65b9\u6cd5\u662f\u5c06\u591a\u4e2aCompartment\u7b80\u5316\u6210\u5c11\u6570Compartment\uff0c\u7b80\u5316\u7ed3\u6784\u7684\u540c\u65f6\u4e5f\u8981\u4fdd\u7559\u6211\u4eec\u8ba4\u4e3a\u6bd4\u8f83\u91cd\u8981\u7684\u6a21\u578b\u8ba1\u7b97\u7279\u6027[24]\u3002<\/span><\/section>\n
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\u8fd8\u53ef\u4ee5\u83b7\u77e5\u66f4\u5fae\u89c2\u7684\u7ed3\u6784\u4fe1\u606f\uff0c\u4f8b\u5982\u7a81\u89e6\u5982\u4f55\u5206\u5e03\uff0c\u5174\u594b\u6027\u7a81\u89e6\u548c\u6291\u5236\u6027\u7a81\u89e6\u7684\u6bd4\u4f8b\u3001\u5206\u5e03\u6a21\u5f0f\u7b49\uff0c\u7ed3\u5408\u4e0a\u8ff0\u53c2\u6570\u53ef\u4ee5\u505a\u66f4\u52a0\u63a5\u8fd1\u751f\u7269\u73b0\u5b9e\u7684\u4eff\u771f\u3002\u4e0a\u56fe\u4e2d\u7684\u4e24\u4e2a\u795e\u7ecf\u5143\u7684\u7ed3\u6784\u975e\u5e38\u76f8\u4f3c\uff0c\u53ef\u662f\u5174\u594b\u6027\u7a81\u89e6\u548c\u6291\u5236\u6027\u7a81\u89e6\u7684\u6bd4\u4f8b\u4ee5\u53ca\u5206\u5e03\u4e0d\u540c\uff0c\u56e0\u6b64\u8fd9\u4e24\u4e2a\u795e\u7ecf\u5143\u7684\u8ba1\u7b97\u7279\u6027\u4e5f\u975e\u5e38\u4e0d\u540c[25]\u3002<\/span><\/section>\n
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\u611f\u77e5\u673a\u6a21\u578b\u4e2d\u5355\u4e2a\u795e\u7ecf\u5143\u5904\u7406\u4fe1\u606f\u7684\u5355\u5c42\u795e\u7ecf\u7f51\u7edc\u65e0\u6cd5\u5b9e\u73b0XOR\u95e8\u8ba1\u7b97\u3002\u5728\u4e0a\u8ff0\u795e\u7ecf\u5143\u4e2d\u65bd\u52a0X\u4fe1\u53f7\u6216\u8005Y\u4fe1\u53f7\u90fd\u53ef\u4ee5\u5f97\u5230\u5bf9\u5e94\u7684\u8109\u51b2\u8f93\u51fa\uff0c\u4f46\u662f\u540c\u65f6\u65bd\u52a0\u4e24\u79cd\u4fe1\u53f7\u5374\u6ca1\u6709\u8109\u51b2\u8f93\u51fa\uff0c\u5373\u7c7b\u4f3cXOR\u95e8\u8ba1\u7b97[27]\u3002<\/span><\/section>\n
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\u795e\u7ecf\u5143AI<\/span><\/strong><\/span><\/section>\n

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\u7c7b\u8111\u667a\u80fd\u53d6\u4e4b\u4e8e\u8111\u5374\u53c8\u4e0d\u5e94\u5b8c\u5168\u53d7\u9650\u4e8e\u8111\uff0c\u56e0\u4e3a\u751f\u7269\u8111\u7684\u5c3a\u5bf8\u662f\u6709\u9650\u5236\u7684\uff0c\u800c\u673a\u5668\u8111\u5374\u4e0d\u53d7\u8fd9\u4e9b\u9650\u5236\u3002\u60f3\u8981\u63a2\u7d22\u8fd9\u4e2a\u9886\u57df\u7684\u4eba\u9700\u8981\u6781\u5ea6\u4e86\u89e3\u4e24\u5927\u9886\u57df\uff0c\u4e00\u662f\u795e\u7ecf\u5143\uff0c\u4e8c\u662f\u4eba\u5de5\u667a\u80fd\u3002\u61c2\u7b2c\u4e8c\u65b9\u9762\u7684\u4eba\u6bd4\u7b2c\u4e00\u65b9\u9762\u591a\uff0c\u53cd\u8fc7\u6765\u505a\u6811\u7a81\u8ba1\u7b97\u7684\u4eba\u4e5f\u4e0d\u4e00\u5b9a\u4e86\u89e3\u4eba\u5de5\u667a\u80fd\u9886\u57df\u77e5\u8bc6\u3002\u81e7\u8001\u5e08\u5efa\u8bae\u5927\u5bb6\u4e0d\u4e00\u5b9a\u62d8\u6ce5\u4e8e\u795e\u7ecf\u5143\u7684\u8ba1\u7b97\u539f\u7406\uff0c\u53ef\u4ee5\u63a2\u7d22\u65e0\u7a77\u7684\u53ef\u80fd\u6027\u53bb\u8fdb\u4e00\u6b65\u63d0\u5347\u4eba\u5de5\u667a\u80fd\u7684\u6027\u80fd[28]\u3002<\/span><\/section>\n
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[3]JR Clay. Determining K+ channel activation curves from K+ channel currents often requires the Goldman\u2013Hodgkin\u2013Katz equation. Front. Cell. Neurosci, 2009<\/span><\/section>\n
[4]W Mel B.. Information processing in dendritic trees, 1994, 6(6): 1031\u20131085<\/span><\/section>\n
[5]Laurent Badel, Sandrine Lefort, Romain Brette, et al. Dynamic I-V Curves Are Reliable Predictors of Naturalistic Pyramidal-Neuron Voltage Traces. Journals, 2008<\/span><\/section>\n
[6]Guillaume Drion, Timothy O\u2019Leary, Eve Marder. Ion channel degeneracy enables robust and tunable neuronal firing rates. proceedings of the national academy of sciences, 2015, 112(38): E5361-E5370<\/span><\/section>\n
[7]J. C. Eccles, R. Llin\u00e1s, K. Sasaki. The excitatory synaptic action of climbing fibres on the Purkinje cells of the cerebellum. The Physiological Society, 1966<\/span><\/section>\n
[8]Jorge Golowasch, Mark S. Goldman, L. F. Abbott, et al. Failure of Averaging in the Construction of a Conductance-Based Neuron Model. JOURNALS, 2002<\/span><\/section>\n
[9]Zang Y., Dieudonn\u00e9 S., De Schutter E.. Voltage-and branch-specific climbing fiber responses in Purkinje cells[J]. Cell reports, 2018, 24(6): 1536\u20131549<\/span><\/section>\n
[10]Michael H\u00e4usser. Dendrites: bug or feature?. current opinion in neurobiology, 2003, 13(3): 372-383<\/span><\/section>\n
[11]Zang Y., De Schutter E.. The cellular electrophysiological properties underlying multiplexed coding in Purkinje cells[J]. Journal of Neuroscience, 2021, 41(9): 1850\u20131863<\/span><\/section>\n
[12]Zang Y., De Schutter E.. The cellular electrophysiological properties underlying multiplexed coding in Purkinje cells[J]. Journal of Neuroscience, 2021, 41(9): 1850\u20131863<\/span><\/section>\n
[13]Yunliang Zang, Sungho Hong, Erik De Schutter. Firing rate-dependent phase responses of Purkinje cells support transient oscillations. Research Article, 2020<\/span><\/section>\n
[14]de la Rocha, Jaime, Doiron, et al. Correlation between neural spike trains increases with firing rate. nature, 2007, 448(7155): 802-806<\/span><\/section>\n
[15]Kuramoto Yoshiki. Cooperative Dynamics of Oscillator CommunityA Study Based on Lattice of Rings. progress of theoretical physics supplement, 1984<\/span><\/section>\n
[16]Schulz, David J, Goaillard, et al. Variable channel expression in identified single and electrically coupled neurons in different animals. nature neuroscience, 2006, 9(3): 356-362<\/span><\/section>\n
[17]David J. Schulz, Jean-Marc Goaillard, Eve E. Marder. Quantitative expression profiling of identified neurons reveals cell-specific constraints on highly variable levels of gene expression. PNAS, 2007<\/span><\/section>\n
[18]Gwendal LeMasson, Eve Marder, L. F. Abbott. Activity-Dependent Regulation of Conductances in Model Neurons. science, 1993, 259(5103)<\/span><\/section>\n
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[23]Grubb, Matthew S., Burrone, et al. Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability. nature, 2010, 465(7301): 1070-1074<\/span><\/section>\n
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[27]Albert Gidon, Timothy Adam Zolnik, Pawel Fidzinski, et al. Dendritic action potentials and computation in human layer 2\/3 cortical neurons. science, 2020, 367(6473)<\/span><\/section>\n
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