{"id":37961,"date":"2022-10-19T22:22:46","date_gmt":"2022-10-19T14:22:46","guid":{"rendered":"https:\/\/swarma.org\/?p=37961"},"modified":"2022-10-19T22:22:46","modified_gmt":"2022-10-19T14:22:46","slug":"covid-19%e6%95%b0%e6%8d%ae%e5%88%86%e6%9e%90%e7%9a%84%e5%8f%af%e5%a4%8d%e7%8e%b0%e6%80%a7%ef%bc%9a%e6%82%96%e8%ae%ba%e3%80%81%e9%99%b7%e9%98%b1%e5%92%8c%e6%9c%aa%e6%9d%a5%e6%8c%91%e6%88%98","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=37961","title":{"rendered":"COVID-19\u6570\u636e\u5206\u6790\u7684\u53ef\u590d\u73b0\u6027\uff1a\u6096\u8bba\u3001\u9677\u9631\u548c\u672a\u6765\u6311\u6218"},"content":{"rendered":"
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\u5728\u6700\u8fd1\u53d1\u8868\u4e8ePNAS Nexus\u7684\u6587\u7ae0\u4e2d\uff0c\u4f5c\u8005\u8ba4\u4e3a\u9700\u8981\u590d\u6742\u7684\u7efc\u5408\u65b9\u6cd5\uff0c\u6765\u7ed3\u5408\u4e0d\u540c\u7684\u6570\u636e\u548c\u4fe1\u6e90\uff0c\u540c\u65f6\u9700\u8981\u4ece\u7edf\u8ba1\u5b66\u7684\u89d2\u5ea6\u6765\u5e73\u8861\u5efa\u6a21\u7684\u56f0\u96be\uff0c\u4ea7\u751f\u6709\u6548\u7684\u63a8\u8bba\u548c\u53ef\u9760\u7684\u9884\u6d4b\u3002\u4f5c\u8005\u7ed3\u5408\u6848\u4f8b\u8ba8\u8bba\u4e86\u6570\u636e\u8d28\u91cf\u600e\u6837\u5f71\u54cd\u65b0\u51a0\u7814\u7a76\u548c\u51b3\u7b56\uff0c\u5e76\u8ba4\u4e3a\u9700\u8981\u65b0\u7684\u8303\u5f0f\u548c\u65b0\u7684\u8bbe\u8ba1\u65b9\u6848\uff0c\u4ee5\u4fbf\u5728\u5904\u7406\u65b0\u51a0\u80ba\u708e\u7b49\u7d27\u6025\u60c5\u51b5\u4e0b\u6536\u96c6\u7684\u6570\u636e\u65f6\u5f97\u51fa\u6709\u610f\u4e49\u4e14\u4fe1\u606f\u4e30\u5bcc\u7684\u53ef\u4fe1\u7ed3\u8bba\u3002<\/span><\/strong><\/p>\n


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\u7814\u7a76\u9886\u57df\uff1a\u6570\u636e\u5206\u6790\uff0c\u7edf\u8ba1\u5b66<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Clelia Di Serio, Antonio Malgaroli, Paolo Ferrari, Ron S Kenett<\/span><\/strong><\/span><\/strong> <\/span>| \u4f5c\u8005<\/strong><\/span><\/strong><\/span><\/strong><\/p>\n

\u5218\u5fd7\u822a\u3001\u5218\u57f9\u6e90<\/span><\/strong><\/span><\/strong> <\/span>| \u8bd1\u8005<\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/p>\n

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\u8bba<\/span>\u6587\u9898\u76ee\uff1a<\/span><\/p>\n

The reproducibility of COVID-19 data analysis: paradoxes, pitfalls, and future challenges<\/span><\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1a<\/span><\/p>\n

https:\/\/academic.oup.com\/pnasnexus\/article\/1\/3\/pgac125\/6673789<\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n


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1. \u80cc\u666f<\/strong><\/span><\/span><\/section>\n
2. COVID-19c\u51fa\u7248\u7269\u7684\u6cdb\u6ee5
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3. \u5386\u53f2\u603b\u662f\u60ca\u4eba\u76f8\u4f3c<\/strong><\/span><\/span><\/section>\n
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5. \u6570\u636e\u8d28\u91cf\u3001\u504f\u89c1\u6765\u6e90\u548cCOVID-19\u6096\u8bba<\/strong><\/span><\/span><\/section>\n
6. \u6570\u636e\u8d28\u91cf\u3001\u6570\u636e\u5171\u4eab\u548c\u53ef\u590d\u73b0\u6027
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<\/p>\n

\u56e0\u6b64\uff0c\u5bf9\u4e00\u79cd\u4f20\u67d3\u75c5\u7684\u63a7\u5236\u4e0d\u80fd\u4ec5\u4ec5\u901a\u8fc7\u75ab\u82d7\u8986\u76d6\u7387\u6765\u5b9e\u73b0\uff0c\u800c\u662f\u9700\u8981\u4ece\u6574\u4f53\u4e0a\u8fdb\u884c\u5904\u7406\u3002\u8fd9\u5305\u62ec\u8bc6\u522b\u7206\u53d1\u6a21\u5f0f\u7684\u201c\u6570\u636e\u9a71\u52a8\u201d\u653f\u7b56\u3001\u6613\u611f\u4eba\u7fa4\u7684\u98ce\u9669\u5256\u6790\u3001\u6784\u5efa\u76d1\u6d4b\u7684\u7edf\u8ba1\u62bd\u6837\u3001\u8ba1\u5212\u6570\u636e\u6574\u5408\u6280\u672f\uff0c\u4ee5\u6574\u5408\u6d41\u52a8\u6027\u548c\u5065\u5eb7\u6570\u636e\u4e0e\u4e34\u5e8a\u4fe1\u606f\u3002\u6240\u6709\u8fd9\u4e9b\u65b9\u6cd5\u7684\u5171\u540c\u70b9\u662f\u6570\u636e\u8d28\u91cf\u3001\u4fe1\u606f\u8d28\u91cf\u548c\u7edf\u8ba1\u601d\u7ef4\u3002<\/strong>\u4e0b\u4e00\u8282\u5c06\u5bf9\u4fe1\u606f\u8d28\u91cf\u6846\u67b6\u8fdb\u884c\u9610\u8ff0\u3002<\/span><\/p>\n


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4. \u4fe1\u606f\u8d28\u91cf<\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


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5. \u6570\u636e\u8d28\u91cf\u3001\u504f\u89c1\u6765\u6e90\u548cCOVID-19\u6096\u8bba<\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u5728\u5904\u7406\u672a\u7ecf\u9002\u5f53\u7814\u7a76\u8bbe\u8ba1\u800c\u6536\u96c6\u7684\u5927\u6570\u636e\u65f6\uff0c\u4e00\u4e2a\u4e3b\u8981\u95ee\u9898\u662f\u51e0\u79cd\u7c7b\u578b\u7684\u504f\u5dee\u53ef\u80fd\u4ea7\u751f\u7684\u5f71\u54cd\uff0c\u5305\u62ec\u9009\u62e9\u6027\u504f\u5dee\u548c\u65e0\u56de\u5e94\u504f\u5dee<\/span>\uff08None Response bias\uff09<\/span>\u3002\u8fd9\u4e9b\u53ef\u80fd\u4f1a\u4ee5\u4e00\u79cd\u77db\u76fe\u7684\u65b9\u5f0f\u5f71\u54cd\u7ed3\u679c\uff0c\u5bfc\u81f4\u6df7\u6742\u504f\u5dee<\/span>\uff08confounding bias\uff09<\/span>\u3002\u5f71\u54cd\u65b0\u51a0\u75ab\u60c5\u6570\u636e\u7684\u4e00\u4e2a\u4e3b\u8981\u504f\u5dee\u6765\u6e90\uff0c\u4e0e\u201c\u975e\u6982\u7387\u201d\u62bd\u6837\u7a0b\u5e8f\u6709\u5173\u3002\u8fd9\u6837\u7684\u6570\u636e\u6536\u96c6\u524a\u5f31\u4e86\u7531\u6b64\u4ea7\u751f\u7684\u7edf\u8ba1\u63a8\u65ad\u3002\u4e8b\u5b9e\u4e0a\uff0c\u6982\u7387\u62bd\u6837\u662f\u57fa\u4e8e\u4e8b\u5148\u5df2\u77e5\u7684\u8bbe\u8ba1\u53d8\u91cf\uff0c\u7528\u4e8e\u5b9a\u4e49\u4eba\u53e3\u6846\u67b6\u7684\u6240\u6709\u5355\u4f4d\u3002\u5728\u975e\u6982\u7387\u62bd\u6837\u4e2d\uff0c\u7eb3\u5165\u6982\u7387\u662f\u672a\u77e5\u7684\u3002\u7cdf\u7cd5\u7684\u62bd\u6837\u65b9\u6cd5\uff0c\u4e0d\u80fd\u901a\u8fc7\u589e\u52a0\u6837\u672c\u7684\u5927\u5c0f\u6765\u89e3\u51b3\u3002<\/strong>\u4eba\u53e3\u89c4\u6a21\u626e\u6f14\u7740\u201c\u653e\u5927\u955c\u201d\u7684\u89d2\u8272\uff0c\u5b83\u653e\u5927\u4e86\u975e\u6982\u7387\u62bd\u6837\u7684\u504f\u5dee\uff0c\u5e76\u53ef\u80fd\u5bfc\u81f4\u9519\u6f0f\u767e\u51fa\u7684\u63a8\u65ad\u3002\u53ef\u4ee5\u8bc1\u660e[14]\uff0c\u5728\u975e\u6982\u7387\u62bd\u6837\u4e0b\uff0c\u8861\u91cf\u7edf\u8ba1\u6a21\u578b\u8bef\u5dee\u91cf\u7684 MSE<\/span>\uff08\u5747\u65b9\u8bef\u5dee\uff09<\/span>\u4f1a\u968f\u7740\u6837\u672c\u5927\u5c0f\u800c\u589e\u52a0\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u4eba\u4eec\u9700\u8981\u5b9e\u65bd\u66ff\u4ee3\u7684\u7edf\u8ba1\u5206\u6790\u65b9\u6cd5\uff0c\u5982\u5404\u79cd\u52a0\u6743\u65b9\u6cd5\u3002\u4e00\u79cd\u9009\u62e9\u662f\u4f7f\u7528\u503e\u5411\u5f97\u5206\u6765\u6784\u5efa\u6743\u91cd\uff0c\u4ee5\u8003\u8651\u975e\u6982\u7387\u6837\u672c\u7684\u504f\u5dee\u3002\u6700\u8fd1\u5728\u5206\u6790\u975e\u6982\u7387\u62bd\u6837\u7684\u5927\u6570\u636e\u65f6\u63d0\u51fa\u4e86\u65b0\u7684\u7edf\u8ba1\u89c6\u89d2[15]\u3002\u8fd9\u79cd\u65b9\u6cd5\u5229\u7528\u6807\u51c6\u7684\u903b\u8f91\u56de\u5f52\u514b\u670d\u4e86\u53ef\u80fd\u7684\u504f\u5dee\uff0c\u8fd9\u79cd\u56de\u5f52\u4f9d\u8d56\u4e8e\u89c2\u5bdf\u53d8\u91cf\u4e4b\u95f4\u51fd\u6570\u5173\u7cfb\u7684\u5148\u9a8c\u5047\u8bbe\u3002\u53e6\u4e00\u79cd\u65b0\u65b9\u6cd5\u662f\u4f7f\u7528\u8d1d\u53f6\u65af\u7f51\u7edc\u6765\u4f30\u8ba1\u503e\u5411\u5f97\u5206[15]\u3002<\/span><\/p>\n


<\/p>\n

\u7136\u800c\uff0c\u5373\u4f7f\u662f\u975e\u6982\u7387\u62bd\u6837\uff0c\u5927\u591a\u6570\u5df2\u53d1\u8868\u7684\u8bba\u6587\u4ecd\u7136\u91c7\u7528\u6807\u51c6\u7edf\u8ba1\u6280\u672f\uff0c\u56e0\u6b64\u5ffd\u7565\u4e86\u53ef\u80fd\u7684\u504f\u5dee\u6765\u6e90\u3002\u9664\u4e86\u9009\u62e9\u6027\u504f\u5dee\u548c\u65e0\u56de\u5e94\u504f\u5dee\u5916\uff0c\u6df7\u6742\u504f\u5dee\u4f1a\u5bfc\u81f4\u5bf9\u534f\u53d8\u91cf\u4f5c\u7528\u7684\u9519\u8bef\u89e3\u91ca\uff0c\u4ee5\u53ca\u77db\u76fe\u7684\u7ed3\u8bba\u3002\u8fd9\u5728\u65b0\u51a0\u75c5\u6bd2\u6570\u636e\u4e2d\u98ce\u9669\u56e0\u7d20\u7684\u89e3\u91ca\u4e2d\u5df2\u7ecf\u5e7f\u6cdb\u51fa\u73b0\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5bf9\u534f\u53d8\u91cf\u7684\u6807\u51c6\u8c03\u6574\u65b9\u6cd5\uff0c\u5982\u4f7f\u7528\u4f18\u52bf\u6bd4\uff0c\u5bfc\u81f4\u4e86\u4e00\u4e9b\u8bef\u5bfc\u6027\u7684\u6096\u8bba\uff0c\u5305\u62ec\u201c\u80a5\u80d6\u6096\u8bba\u201d\u3001\u201cACE \u6291\u5236\u5242\u6096\u8bba\u201d\u548c\u201c\u5438\u70df\u6096\u8bba\u201d\u3002\u5927\u591a\u6570\u8fd9\u4e9b\u6096\u8bba\u53ef\u5f52\u56e0\u4e8e\u4ea7\u751f\u6df7\u6dc6\u6548\u5e94\u7684\u672a\u89e3\u91ca\u7684\u53ef\u53d8\u6027\u6765\u6e90\u3002\u8fd9\u5305\u62ec\u5bf9\u7f3a\u5931\u503c\u7684\u9519\u8bef\u4f30\u7b97\uff0c\u6570\u636e\u5e93\u4e2d\u7f3a\u4e4f\u7edf\u4e00\u7684\u53d8\u91cf\u5b9a\u4e49\uff0c\u4ee5\u53ca\u5ffd\u7565\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\u4e0e\u5e74\u9f84\u7684\u4ea4\u4e92\u6548\u5e94\u3002\u6b64\u5916\uff0c\u6765\u81ea\u4e0d\u540c COVID-19 \u611f\u67d3\u6d6a\u6f6e\u7684\u6570\u636e\u4e0d\u5bb9\u6613\u5408\u5e76\u548c\u6bd4\u8f83\uff0c\u8fd9\u4e0d\u4ec5\u662f\u56e0\u4e3a\u75c5\u6bd2\u53d8\u4f53\u5728\u611f\u67d3\u548c\u81f4\u75c5\u673a\u5236\u4e0a\u53ef\u80fd\u6709\u751f\u7269\u5b66\u4e0a\u7684\u5dee\u5f02\uff0c\u800c\u4e14\u8fd8\u56e0\u4e3a\u63a5\u89e6\u6cbb\u7597\u5242\u7684\u65f6\u95f4\uff0c\u4ee5\u53ca\u65b0\u7597\u6cd5\u7684\u5f15\u5165\u53ef\u80fd\u5f71\u54cd\u4e34\u5e8a\u7ed3\u679c\u3002<\/span><\/p>\n


<\/p>\n

\u4f8b\u5982\uff0c\u8bb8\u591a\u65b0\u51a0\u80ba\u708e\u7814\u7a76\u8bba\u6587[16]\u8bc4\u4f30\u4e86\u80a5\u80d6\u7684\u4f5c\u7528\uff0c\u56e0\u4e3a\u80a5\u80d6\u662f\u5fc3\u8840\u7ba1\u75be\u75c5\u4e2d\u4e3b\u8981\u7684\u98ce\u9669\u56e0\u7d20\u3002\u5728\u7b2c\u4e00\u6ce2\u65b0\u51a0\u80ba\u708e\u671f\u95f4\uff0c\u80a5\u80d6\u88ab\u8bc1\u660e\u662f\u4e00\u4e2a\u98ce\u9669\u56e0\u7d20\uff0c\u4f46\u4e5f\u6709\u7814\u7a76\u58f0\u79f0\u80a5\u80d6\u5177\u6709\u201c\u4fdd\u62a4\u6027\u201d\u6216\u6ca1\u6709\u5f71\u54cd[17]\u3002\u8fd9\u4e9b\u76f8\u4e92\u77db\u76fe\u7684\u7ed3\u679c\u6765\u81ea\u8bb8\u591a\u6f5c\u5728\u7684\u8b66\u544a\uff0c\u4f8b\u5982\uff1a\uff081\uff09\u8bc4\u4f30\u80a5\u80d6\u7684\u4e0d\u540c\u9009\u62e9\u6807\u51c6\u3002\u4f53\u91cd\u6307\u6570<\/span>\uff08BMI\uff09<\/span>\u662f\u4e00\u4e2a\u57fa\u672c\u5de5\u5177\uff0c\u4f46\u5176\u672c\u8eab\u4e0d\u8db3\u4ee5\u5728\u6ca1\u6709\u4e34\u5e8a\u8bc4\u4f30\u7684\u60c5\u51b5\u4e0b\u8bca\u65ad\u80a5\u80d6\u75c7\u3002\uff082\uff09  \u80a5\u80d6\u4e34\u5e8a\u8bca\u65ad\u7684\u6807\u51c6\u548c\u4e34\u754c\u503c\u56e0\u56fd\u5bb6\u800c\u5f02\u5e76\u53d6\u51b3\u4e8e\u79cd\u65cf\uff0c\uff083\uff09 BMI \u7684\u7f3a\u5931\u503c\u4e5f\u53ef\u80fd\u4f1a\u5f71\u54cd\u7ed3\u8bba\u3002\u5728\u75ab\u60c5\u7a81\u7136\u7206\u53d1\u7684\u60c5\u51b5\u4e0b\uff0c\u91cd\u75c7\u60a3\u8005\u7684\u4f53\u91cd\u548c\u8eab\u9ad8\u53d8\u91cf\u5f80\u5f80\u5f88\u96be\u83b7\u5f97\u3002\u8fd9\u4ee3\u8868\u4e86\u4e00\u79cd\u5ba1\u67e5\u6548\u5e94\uff0c\u800c\u4e0d\u662f\u201c\u968f\u673a\u7f3a\u5931\u201d\u7684\u60c5\u51b5\uff0c\u56e0\u6b64\u4e0d\u80fd\u901a\u8fc7\u7b80\u5355\u7684\u6570\u636e\u63d2\u8865\u6765\u7ea0\u6b63\u3002\u53e6\u4e00\u4e2a\u6096\u8bba\u6307\u7684\u662f\u5e7f\u6cdb\u8ba8\u8bba\u7684\u4e60\u60ef\u6027\u5438\u70df\u8005\u611f\u67d3\u65b0\u51a0\u80ba\u708e\u7684\u4f4e\u98ce\u9669\u3002\u8bb8\u591a\u8bba\u6587\u62a5\u544a\u79f0\uff0c\u6d3b\u8dc3\u5438\u70df\u8005\u4e0e\u65b0\u51a0\u80ba\u708e\u7684\u4e25\u91cd\u7a0b\u5ea6[18]\u4e4b\u95f4\u6ca1\u6709\u663e\u8457\u76f8\u5173\u6027\uff0c\u9a73\u65a5\u4e86\u5438\u70df\u5bf9\u547c\u5438\u529f\u80fd\u7684\u5f71\u54cd\u3002\u7136\u800c\uff0c\u53ef\u4ee5\u8bc1\u660e\uff0c\u5438\u70df\u53d8\u91cf\u901a\u5e38\u6d4b\u91cf\u5f97\u4e0d\u597d<\/span>\uff080\/1\u53d8\u91cf\uff09<\/span>\u3002\u8fd9\u4e9b\u6570\u636e\u4e3b\u8981\u7531\u4e0d\u518d\u5438\u70df\u7684\u5e74\u9f84\u7ec4\u4f4f\u9662\u7684\u91cd\u75c7\u60a3\u8005\u7ec4\u6210\u3002\u8fd9\u4e2a\u6096\u8bba\u5bfc\u81f4\u9009\u62e9\u6027\u504f\u5dee\u3002ACE \u6291\u5236\u5242\u6096\u8bba\u4e5f\u5b58\u5728\u7c7b\u4f3c\u7684\u73b0\u8c61\uff0cACE \u6291\u5236\u5242\u6096\u8bba\u662f\u65b0\u51a0\u80ba\u708e\u7b2c\u4e00\u9636\u6bb5\u7684\u4e00\u4e2a\u91cd\u8981\u8ba8\u8bba\u8bdd\u9898[19]\u3002\u8d77\u521d\uff0c\u636e\u62a5\u9053\u63a5\u53d7 ACE \u6291\u5236\u5242\u6cbb\u7597\u7684\u60a3\u8005\u611f\u67d3\u65b0\u51a0\u80ba\u708e\u7684\u98ce\u9669\u589e\u52a0\u3002\u540e\u6765\uff0c\u60c5\u51b5\u6b63\u597d\u76f8\u53cd\uff0c\u5373 ACE \u6291\u5236\u5242\u836f\u7269\u7684\u4fdd\u62a4\u4f5c\u7528[20]\u3002\u5728\u6211\u4eec\u5ba1\u67e5\u7684\u5927\u591a\u6570\u6587\u732e\u4e2d\uff0c\u6ca1\u6709\u9002\u5f53\u8003\u8651\u5e74\u9f84\u5bf9\u6240\u6709\u534f\u53d8\u91cf\u7684\u6df7\u6dc6\u5f71\u54cd\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u4e9b\u73b0\u8c61\u88ab\u5f52\u7c7b\u4e3a\u201c\u5047\u4fdd\u62a4\u6027<\/span>\uff08false protectivity\uff09<\/span>\u201d[21, 22]\u3002\u5b83\u4eec\u7531\u4e8e\u6709\u504f\u7684\u6d4b\u91cf\uff0c\u5ffd\u7565\u4e86\u57fa\u7840\u6570\u636e\u7ed3\u6784\u548c\u6570\u636e\u6574\u5408\uff0c\u800c\u8fd9\u4e9b\u662f\u4fe1\u606f\u8d28\u91cf\u6846\u67b6\u4e2d\u9700\u8981\u8003\u8651\u7684\u7b2c\u4e8c\u548c\u7b2c\u4e09\u4e2a\u7ef4\u5ea6\u3002\u7f3a\u4e4f\u8bbe\u8ba1\u7684\u7814\u7a76\u53ef\u80fd\u4f1a\u5bf9\u6cbb\u7597\u65b9\u6848\u4ea7\u751f\u4e25\u91cd\u5f71\u54cd\u3002<\/span><\/p>\n


<\/p>\n

\u53e6\u4e00\u4e2a\u95ee\u9898\u662f\uff0c\u6570\u636e\u4e0d\u662f\u6309\u7167\u5bf9\u7167\u8bd5\u9a8c\u8bbe\u8ba1\u6536\u96c6\u7684\uff0c\u901a\u5e38\u4f7f\u7528\u201c\u63a7\u5236\u201d\u5b9a\u4e49\uff0c\u56e0\u6b64\u8fd9\u4e9b\u65b0\u51a0\u6570\u636e\u4e0d\u80fd\u5728\u89c2\u5bdf\u56de\u987e\u8bbe\u8ba1\u4e2d\u6784\u5efa\u3002\u4e0e\u8bb8\u591a\u53d1\u8868\u7684\u8bba\u6587\u4e00\u6837\uff0c\u4eba\u4eec\u9700\u8981\u77e5\u9053\u5728\u8fd9\u79cd\u6d41\u884c\u75c5\u4e2d\uff0c\u4ec0\u4e48\u662f\u9002\u5f53\u7684\u201c\u63a7\u5236\u201d\u3002<\/span><\/p>\n


<\/p>\n

\u5bf9\u7167\u8bd5\u9a8c\u7684\u4e00\u822c\u6027\u8d28\u53d6\u51b3\u4e8e\u6240\u8003\u8651\u7684\u7814\u7a76\u7c7b\u578b\u548c\u7814\u7a76\u5047\u8bbe\uff0c\u5e94\u8be5\u4ed4\u7ec6\u9009\u62e9\u3002\u6839\u636e\u5386\u53f2\u6587\u732e[23]\uff0c\u5e94\u8be5\u6839\u636e\u53ef\u6bd4\u6027\u539f\u5219\u9009\u62e9\u5bf9\u7167\uff0c\u7279\u522b\u662f\uff1a\uff08i\uff09\u6240\u6709\u6bd4\u8f83\u90fd\u5e94\u5728\u201c\u7814\u7a76\u57fa\u7840\u201d\u5185\u8003\u8651\uff0c\u8fd9\u610f\u5473\u7740\u4f4f\u9662\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u7684\u5bf9\u7167\u5e94\u8be5\u662f\u975e\u4f4f\u9662\u7684\u65b0\u51a0\u80ba\u708e\u60a3\u8005\uff1b\uff08ii\uff09\u5254\u9664\u6df7\u6dc6\u56e0\u7d20\uff1a\u5728\u5f71\u54cd\u75be\u75c5\u98ce\u9669\u65f6\uff0c\u5e94\u8003\u8651\u4e0d\u540c\u66b4\u9732\u6c34\u5e73\u7684\u4f9d\u8d56\u6027\uff0c\u4ee5\u907f\u514d\u626d\u66f2\uff1b\u4ee5\u53ca\uff08iii\uff09\u53ef\u6bd4\u7684\u51c6\u786e\u6027\u3002<\/span><\/p>\n


<\/p>\n

\u4e0d\u5e78\u7684\u662f\uff0c\u7531\u4e8e\u5c1a\u672a\u7cfb\u7edf\u5730\u5bf9\u65e0\u75c7\u72b6\u6216\u8f7b\u75c7\u60a3\u8005\u8fdb\u884c\u901a\u7528\u7684\u9f3b\u54bd rt-PCR \u7b5b\u67e5\uff0c\u56e0\u6b64\u65e0\u6cd5\u83b7\u5f97\u975e\u4f4f\u9662\u60a3\u8005\u7684\u4fe1\u606f\u3002\u6240\u4ee5\uff0c\u5927\u591a\u6570\u8bba\u6587\u4f7f\u7528\u4ece\u521d\u7ea7\u4fdd\u5065\u6570\u636e\u5e93\u4e2d\u968f\u673a\u62bd\u6837\u7684\u5bf9\u7167\u7ec4\uff0c\u800c\u5bf9\u5bf9\u7167\u7ec4\u7684\u75be\u75c5\u72b6\u6001\u6ca1\u6709\u4efb\u4f55\u4e86\u89e3\u3002<\/span><\/p>\n


<\/p>\n

\u5927\u591a\u6570\u5173\u4e8e\u65b0\u51a0\u75c5\u6bd2\u7684\u7814\u7a76\u90fd\u662f\u9488\u5bf9\u75c5\u4f8b\u7684\u5206\u6790\u3002\u9002\u5f53\u7684\u5206\u6790\u5e94\u8be5\u5728\u4e00\u4e2a\u590d\u6742\u7684\u4f9d\u8d56\u6027\u7f51\u7edc\u7ed3\u6784\u4e2d\u8c03\u67e5\u75c5\u4eba\u7684\u60c5\u51b5\uff0c\u4ee5\u8bc4\u4f30\u98ce\u9669\u56e0\u7d20\u7684\u201c\u51c0\u201d\u5f71\u54cd\uff0c\u4ece\u800c\u91c7\u53d6\u56e0\u679c\u63a8\u65ad\u7684\u65b9\u6cd5\u3002\u4e8b\u5b9e\u4e0a\uff0c\u6570\u636e\u9a71\u52a8\u7684\u89c6\u89d2\u9700\u8981\u6574\u5408\u5148\u9a8c\u4e34\u5e8a\u77e5\u8bc6\uff0c\u4e0d\u80fd\u5b8c\u5168\u4f9d\u8d56\u7b97\u6cd5<\/strong>\u3002\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u53ef\u80fd\u65e0\u6cd5\u63cf\u8ff0\u65b0\u51a0\u75c5\u6bd2\u98ce\u9669\u56e0\u7d20\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u56e0\u4e3a\u5b83\u4eec\u672c\u8d28\u4e0a\u53ea\u662f\u5728\u8c03\u67e5\u76f8\u5173\u6027\u800c\u975e\u56e0\u679c\u6027[24]\u3002\u4efb\u4f55\u56e0\u679c\u6027\u7684\u7ed3\u8bba\u90fd\u5e94\u8be5\u7acb\u8db3\u4e8e\u9a8c\u8bc1\u548c\u654f\u611f\u6027\u5206\u6790\u7684\u89d2\u5ea6\uff0c\u4ee5\u786e\u4fdd\u7ed3\u8bba\u7684\u53ef\u590d\u73b0\u6027[25]\u3002<\/span><\/p>\n


<\/p>\n

\u56e0\u6b64\uff0c\u5bf9\u4e8e\u8fd9\u4e9b\u7c7b\u578b\u7684\u6570\u636e\uff0c\u9700\u8981\u5f00\u53d1\u65b0\u7684\u5206\u6790\u8303\u5f0f\u3002\u8fd9\u4e9b\u65b9\u6cd5\u5e94\u8be5\u80fd\u591f\u63a7\u5236\u6df7\u6742\u504f\u5dee\u3001\u4e0d\u540c\u7684\u6570\u636e\u6574\u5408\u534f\u8bae\u3001\u6570\u636e\u5206\u8fa8\u7387\u548c\u6570\u636e\u7ed3\u6784\uff0c\u5373\u91cd\u70b9\u5173\u6ce8\u4fe1\u606f\u8d28\u91cf\u7684\u4ea7\u751f\u3002<\/span><\/p>\n


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\u73b0\u6709\u6587\u732e\u4e2d\u5df2\u7ecf\u5e7f\u6cdb\u8ba8\u8bba\u4e86\u6570\u636e\u8d28\u91cf\u5dee\u5bf9\u533b\u5b66\u7684\u5f71\u54cd\uff0826\uff09\u3002\u7136\u800c\uff0c\u5982\u4eca\u533b\u7597\u6570\u636e\u7684\u53ef\u7528\u6027\u4e0d\u65ad\u63d0\u9ad8\uff0c\u6570\u636e\u91c7\u96c6\u65b9\u6cd5\u4e5f\u53d1\u751f\u4e86\u53d8\u5316\uff0c\u8fd9\u7ed9\u6570\u636e\u8d28\u91cf\u8303\u5f0f\u5e26\u6765\u4e86\u65b0\u7684\u6311\u6218\uff0c\u4e0e\u4e4b\u76f8\u5bf9\u5e94\u7684\u662f\u66f4\u591a\u7684\u6280\u672f\u548c\u4f26\u7406\u7279\u5f81\uff0c\u5982\uff08i\uff09\u6570\u636e\u5171\u4eab\uff0c\uff08ii\uff09\u6570\u636e\u6574\u5408\uff0c\u4ee5\u53ca\uff08iii\uff09\u9690\u79c1\u4fdd\u62a4\u3002<\/span><\/p>\n


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6. \u6570\u636e\u8d28\u91cf\u3001\u6570\u636e\u5171\u4eab\u548c\u53ef\u590d\u73b0\u6027<\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/p>\n

\u4e00\u4e2a\u7ecf\u5e38\u88ab\u5ffd\u89c6\u7684\u91cd\u8981\u95ee\u9898\u662f\u5728\u5206\u4eab\u4e34\u5e8a\u6570\u636e\u65b9\u9762\u6301\u7eed\u5b58\u5728\u7684\u969c\u788d\u3002<\/span>\u4e8b\u5b9e\u4e0a\uff0c\u6570\u636e\u5171\u4eab\u5e76\u4e0d\u603b\u662f\u88ab\u79ef\u6781\u770b\u5f85\uff0c\u5bf9\u5b83\u7684\u770b\u6cd5\u548c\u89c2\u70b9\u56e0\u7814\u7a76\u9886\u57df\u7684\u4e0d\u540c\u800c\u4e0d\u540c\u3002<\/span>\u8fd9\u5e94\u8be5\u662f\u6700\u91cd\u8981\u7684\u95ee\u9898\u3002<\/span>\u6570\u636e\u5e94\u8be5\u4ee5\u5b8c\u6574\u7684\u65b9\u5f0f\u5171\u4eab\uff0c\u751a\u81f3\u53ef\u80fd\u5728\u6570\u636e\u91c7\u96c6\u4ecd\u5728\u8fd0\u884c\u548c\u4fe1\u606f\u6536\u96c6\u7684\u65f6\u5019\u3002<\/span>\u5728\u751f\u7269\u533b\u5b66\u4e2d\uff0c\u6570\u636e\u5171\u4eab\u662f\u6700\u57fa\u672c\u7684\uff0c\u56e0\u4e3a\uff1a<\/span>\uff08i\uff09\u5b83\u5141\u8bb8\u7814\u7a76\u7684\u53ef\u91cd\u590d\u6027\uff0c\uff08ii\uff09\u5f53\u8bbe\u8ba1\u826f\u597d\u7684\u7814\u7a76\u8f83\u5c11\u65f6\uff0c\u5b83\u5e2e\u52a9\u79d1\u5b66\u5bb6\u4f7f\u7528\u771f\u5b9e\u4e16\u754c\u7684\u6570\u636e\u96c6\uff1b<\/span>\u4ee5\u53ca\uff08iii\uff09\u5b83\u901a\u8fc7\u5206\u6790\u4ee5\u524d\u7684\u53d1\u73b0\u4fc3\u8fdb\u79d1\u5b66\u5de5\u4f5c\u548c\u8fdb\u6b65[27-29]\u3002<\/span><\/section>\n

<\/span><\/section>\n

\u4e00\u4e2a\u7a81\u51fa\u6570\u636e\u5171\u4eab\u5e26\u6765\u5de8\u5927\u597d\u5904\u7684\u8457\u540d\u4f8b\u5b50\u662f\u6297\u708e\u836f\u7269 Rofecoxib\u3002\u8fd9\u79cd\u836f\u7269\u57281999\u5e74\u88ab\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40<\/span>\uff08FDA\uff09<\/span>\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u6025\u6027\u75bc\u75db\u548c\u75db\u7ecf\u3002\u8be5\u836f\u7269\u516c\u53f8\u63d0\u4f9b\u7684\u4e34\u5e8a\u6570\u636e<\/span>\uff08\u67098076\u540d\u5165\u9009\u60a3\u8005\u7684 VIGOR \u8bd5\u9a8c\uff09<\/span>\u8868\u660e\uff0c\u8be5\u836f\u7269\u4f18\u4e8e\u5176\u4ed6\u6b62\u75db\u836f\u3002\u5728\u6570\u636e\u91c7\u96c6\u8fc7\u7a0b\u4e2d\uff0c\u53d1\u73b0\u4e25\u91cd\u5fc3\u810f\u95ee\u9898\u7684\u98ce\u9669\u589e\u52a0\uff0c\u4f46\u5236\u9020\u5546\u51b3\u5b9a\u4fdd\u7559\u8be5\u4fe1\u606f\uff0c\u5e76\u5c06 VIGOR \u7684\u7ed3\u679c\u4e0e\u53e6\u4e00\u9879Rofecoxib \u8bd5\u9a8c\u7684\u7ed3\u679c\u76f8\u7ed3\u5408\uff0c\u6de1\u5316\u4e86\u8fd9\u79cd\u526f\u4f5c\u7528[30]\u3002\u5728\u63a5\u4e0b\u6765\u7684\u51e0\u5e74\u91cc\uff0c\u8bb8\u591a\u62a5\u544a\u547c\u5401\u6ce8\u610f\u5fc3\u8840\u7ba1\u95ee\u9898\u7684\u98ce\u9669\u589e\u52a0[31, 32]\uff0c\u8fd9\u8feb\u4f7f\u5236\u9020\u5546\u5728 2004 \u5e74\u64a4\u56de\u8be5\u836f\u5e76\u627f\u8ba4\u5b83\u9690\u7792\u4e86\u4fe1\u606f[33, 34]\u30022007\u5e74\uff0c\u5236\u9020\u5546\u5ba3\u5e03\u652f\u4ed8 48.5 \u4ebf\u7f8e\u5143\u4ee5\u7ed3\u675f\u6570\u5343\u8d77\u8bc9\u8bbc\uff0c\u8fd9\u662f\u6709\u53f2\u4ee5\u6765\u6700\u5927\u7684\u836f\u7269\u548c\u89e3\u6848\u3002\u8fd9\u79cd\u7ecf\u9a8c\u6709\u52a9\u4e8e\u6539\u53d8\u751f\u7269\u533b\u5b66\u7814\u7a76\u3002\u8fd1\u5341\u5e74\u6765\uff0c\u751f\u7269\u533b\u5b66\u7814\u7a76\u4e2d\u7684\u6570\u636e\u5171\u4eab\u53d8\u5f97\u66f4\u52a0\u666e\u904d\uff0c\u800c\u6c14\u8c61\u5b66\u548c\u7ecf\u6d4e\u5b66\u7b49\u5176\u4ed6\u7814\u7a76\u9886\u57df\u7684\u6570\u636e\u5171\u4eab\u4e00\u76f4\u662f\u5e38\u89c1\u7684\u505a\u6cd5\u3002<\/span><\/p>\n


<\/p>\n

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5. Dattner I et al. 2022. The role of statisticians in the response to COVID-19 in Israel – a holistic point of view, Israel. Israel J Health Pol Res. 11. DOI: 10.1186\/s13584-022-00531-y.<\/span><\/p>\n

6. Esteva A et al. 2021. Covid-19 information retrieval with deeplearning based semantic search, question answering, and abstractive summarization. NPJ Digit Med. 4(1):1\u20139.<\/span><\/p>\n

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9. Bramstedt KA. 2020. The carnage of substandard research during the COVID-19 pandemic: a call for quality. J Med Ethics. 46:803\u2013807. M edethics\u20142020\u2013106494. {BMJ}.<\/span><\/p>\n

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17. Biscarini S et al. 2020. The obesity paradox: analysis from the SMAtteo COvid-19 REgistry (SMACORE) cohort. Nutr Metab Cardiovasc Dis. 30(11):1920\u20131925.<\/span><\/p>\n

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24. Calster BV 2021. Methodology over metrics: current scientific standards are a disservice to patients and society, J Clin Epidemiol. 138;219\u2013226<\/span><\/p>\n

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35. Devriendt S, Shabani M, Borry P 2021. Data sharing in biomedical sciences: a systematic review of incentives. Biopreserv Biobanking. 19(3):219\u2013227.<\/span><\/p>\n

36. Poli C. 2019. Researcher data sharing behaviour: an application of two models based on the Theory of Planned Behavior and Neoinstitutional theory [master\u2019s thesis]. [Milan]: Vita-Salute San Raffaele University.<\/span><\/p>\n

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42. Schulz PJ, Nakamoto K. 2022. The perils of misinformation: when health literacy goes awry. Nat Rev Nephrol. 18:135\u2013136. 43. Du S, et al. 2018. Health literacy and health outcomes in hypertension: an integrative review. Int J Nurs Sci. 5(3):301\u2013309.<\/span><\/p>\n

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