{"id":39965,"date":"2023-01-24T22:42:14","date_gmt":"2023-01-24T14:42:14","guid":{"rendered":"https:\/\/swarma.org\/?p=39965"},"modified":"2023-01-24T22:42:14","modified_gmt":"2023-01-24T14:42:14","slug":"cell%e9%80%9f%e9%80%92%ef%bc%9a%e4%bf%a1%e6%81%af%e8%ae%ba%e8%a7%86%e8%a7%92%e4%b8%8b%e7%9a%84%e8%a1%b0%e8%80%81%ef%bc%9a%e8%a1%a8%e8%a7%82%e9%81%97%e4%bc%a0%e4%bf%a1%e6%81%af%e4%b8%a2%e5%a4%b1","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=39965","title":{"rendered":"Cell\u901f\u9012\uff1a\u4fe1\u606f\u8bba\u89c6\u89d2\u4e0b\u7684\u8870\u8001\uff1a\u8868\u89c2\u9057\u4f20\u4fe1\u606f\u4e22\u5931\u662f\u54fa\u4e73\u52a8\u7269\u8870\u8001\u7684\u539f\u56e0\u4e4b\u4e00"},"content":{"rendered":"
\n
\n
\n
\n
<\/div>\n


<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/p>\n

\u5173\u952e\u8bcd\uff1a\u8870\u8001\uff0c\u8868\u89c2\u9057\u4f20\uff0c\u4fe1\u606f\u8bba\uff0c\u71b5\u589e<\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong>
<\/p>\n


<\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/p>\n<\/section>\n

\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
\n

<\/strong><\/p>\n


<\/p>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n
\n
\u8bba\u6587\u9898\u76ee\uff1aLoss of epigenetic information as a cause of mammalian aging<\/span><\/section>\n
\u8bba\u6587\u6765\u6e90\uff1aCell<\/em><\/span><\/section>\n
\u8bba\u6587\u5730\u5740\uff1ahttps:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(22)01570-7<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n


<\/p>\n


<\/p>\n

\u6240\u6709\u6709\u751f\u547d\u4e4b\u7269\u90fd\u4f1a\u7ecf\u5386\u71b5\u589e\uff0c\u5177\u4f53\u8868\u73b0\u4e3a\u57fa\u56e0\u53ca\u8868\u89c2\u4fe1\u606f\u7684\u4e22\u5931\u3002\u5728\u9175\u6bcd\u4e2d\uff0c\u8868\u89c2\u4fe1\u606f\u968f\u65f6\u95f4\u7684\u4e22\u5931\uff0c\u662f\u7531\u4e8e\u67d3\u8272\u8d28\u4fee\u6539\u86cb\u767d\u7531\u4e8e DNA \u65ad\u88c2\u5bfc\u81f4\u7684\u91cd\u5b9a\u4f4d\u4f7f\u5176\u5931\u53bb\u81ea\u8eab\u7279\u5f81\uff0c\u8fd9\u662f\u9175\u6bcd\u8870\u8001\u7684\u6807\u5fd7\u4e4b\u4e00\u3002\u4f7f\u7528ICE<\/span>\uff08\u4eba\u5de5\u8bf1\u5bfc\u7684\u8868\u89c2\u57fa\u56e0\u7ec4\u6539\u53d8\uff09<\/span>\uff0c\u8be5\u7814\u7a76 DNA \u4fee\u590d\u53d1\u73b0\u5728\u751f\u7406\u3001\u8ba4\u77e5\u53ca\u5206\u5b50\u5c42\u9762\u52a0\u901f\u4e86\u8870\u8001\uff0c\u5305\u62ec\u4fb5\u8680\u8868\u89c2\u57fa\u56e0\u666f\u89c2\u3001\u7ec6\u80de\u5206\u5316\u3001\u8870\u8001\u53caDNA\u7532\u57fa\u5316\u8fdb\u7a0b\u7684\u52a0\u901f\u3002\u800cDNA\u7532\u57fa\u5316\u65f6\u949f\u53ef\u4ee5\u901a\u8fc7OSK\u4ecb\u5bfc\u7684\u673a\u5236\u9006\u8f6c\uff0c\u8fd9\u4e5f\u7b26\u5408\u4fe1\u606f\u8bba\u89c6\u89d2\u4e0b\u5bf9\u8870\u8001\u7684\u7406\u89e3\uff0c\u5373\u7531\u4e8e\u4fe1\u606f\u4e22\u5931\u662f\u4e00\u4e2a\u53ef\u9006\u7684\u8870\u8001\u539f\u56e0\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u8870\u8001\u7684\u6807\u5fd7\uff0c\u662f\u7ec6\u80de\u529f\u80fd\u548c\u72b6\u6001\u968f\u65f6\u95f4\u7684\u6539\u53d8\uff0c\u7136\u800c\u8fd9\u53ea\u662f\u4ece\u786c\u4ef6\u5c42\u9762\u6765\u770b\uff1b\u4ece\u8f6f\u4ef6\u6765\u770b\uff0c\u751f\u547d\u662f\u4fe1\u606f\u4e0e\u73af\u5883\u7684\u4ea4\u4e92\u4e0b\u6d8c\u73b0\u7684\u6a21\u5f0f\uff0c\u5f53\u5173\u952e\u4fe1\u606f\u4e22\u5931\uff0c\u751f\u547d\u5bf9\u5e94\u7684\u7cfb\u7edf\u5c31\u4f1a\u51fa\u6545\u969c\uff0c\u8fd9\u662f\u57fa\u4e8e\u4fe1\u606f\u8bba\u5bf9\u8870\u8001\u7684\u89e3\u91ca\u3002\u5b58\u50a8\u751f\u547d\u6240\u9700\u7684\u4fe1\u606f\u4e0d\u6b62\u662fDNA\u5e8f\u5217<\/span>\uff08\u57fa\u56e0\u7ec4\uff09<\/span>\uff0c\u8fd8\u5305\u62ec\u5bf9DNA\u7684\u4fee\u9970<\/span>\uff08\u7532\u57fa\u5316\uff09<\/span>\u3002\u540e\u8005\u88ab\u79f0\u4e3a\u8868\u89c2\u57fa\u56e0\u7ec4\uff0c\u53ef\u51b3\u5b9aDNA\u5e8f\u5217\u662f\u5426\u88ab\u8868\u8fbe\u3002\u5982\u5c06DNA\u770b\u6210\u662f\u56fe\u7eb8\uff0c\u8868\u89c2\u57fa\u56e0\u7ec4\u5b58\u50a8\u7684\u5219\u662f\u811a\u6ce8\uff0c\u6807\u51fa\u662f\u5426\u8981\u7ec4\u88c5\u8fd9\u4e00\u96f6\u4ef6\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5f53\u7ec6\u80de\u590d\u5236\u65f6\uff0c\u4e0d\u4ec5\u4f1a\u79ef\u7d2f\u65b0\u53d1\u7a81\u53d8\uff0c\u6539\u53d8\u57fa\u56e0\u7ec4\uff0c\u8fd8\u4f1a\u5ffd\u7565\u539f\u7ec6\u80de\u4e0a\u7684\u8868\u89c2\u4fe1\u606f\uff0c\u5373\u6539\u53d8\u8868\u89c2\u57fa\u56e0\u7ec4\u3002\u5728\u4eba\u5de5\u8bf1\u5bfc\u6539\u53d8\u5c0f\u9f20\u7684\u8868\u89c2\u57fa\u56e0\u7ec4\u540e\uff0c\u53d1\u73b0\u5c0f\u9f20\u7684\u8868\u89c2\u5e74\u9f84\u589e\u52a0<\/span>\uff08\u56fe1\uff09<\/span>\uff0c\u4e14ICE\u5c0f\u9f20\u7531\u4e8e\u5b9e\u9a8c\u5904\u7406\uff0c\u5bfc\u81f4\u8868\u89c2\u4fe1\u606f\u4e22\u5931\u540e\uff0c\u8870\u8001\u8fc7\u7a0b\u52a0\u901f<\/span>\uff08\u56fe2\uff09<\/span>\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u8be5\u7814\u7a76\u8fd8\u6307\u51fa\uff0c\u4e0a\u8ff0\u8868\u89c2\u9057\u4f20\u5931\u8c03\u5f15\u8d77\u7684\u8870\u8001\u5e76\u975e\u4e0d\u53ef\u9006\uff0c\u901a\u8fc7\u57fa\u56e0\u7597\u6cd5\uff0c\u4fee\u65393\u79cd\u5e72\u7ec6\u80de\u6d3b\u8dc3\u7684\u57fa\u56e0 Oct4\u3001Sox2 \u548c Klf4\uff0c\u53ef\u4ee5\u5e2e\u52a9\u5b9e\u9a8c\u5c0f\u9f20\u7684\u7ec6\u80de\u6062\u590d\u5230\u5e74\u8f7b\u72b6\u6001\uff0c\u8ba9\u8868\u89c2\u9057\u4f20\u5931\u8c03\u7684\u7ec6\u80de\u91cd\u65b0\u542f\u52a8\u3002\u8fd9\u4e3a\u6062\u590d\u7ec6\u80de\u6d3b\u529b\uff0c\u63a7\u5236\u8870\u8001\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u3002<\/span><\/p>\n


<\/span><\/p>\n

<\/p>\n

\u56fe1. \u6b63\u5e38\u548cICE\u5c0f\u9f20\u7684\u8868\u89c2\u5e74\u9f84<\/span><\/p>\n


<\/span><\/p>\n

<\/p>\n

\u56fe2. ICE\u4e0e\u6b63\u5e38\u5c0f\u9f20\u7684\u751f\u7406\u8868\u73b0<\/span><\/p>\n


<\/span><\/p>\n


<\/section>\n
\n
\n
\n
\n

\u590d\u6742\u79d1\u5b66\u6700\u65b0\u8bba\u6587<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n


<\/p>\n<\/section>\n

\u96c6\u667a\u6591\u56fe\u9876\u520a\u8bba\u6587\u901f\u9012\u680f\u76ee\u4e0a\u7ebf\u4ee5\u6765\uff0c\u6301\u7eed\u6536\u5f55\u6765\u81eaNature\u3001Science<\/span>\u7b49\u9876\u520a\u7684\u6700\u65b0\u8bba\u6587\uff0c\u8ffd\u8e2a\u590d\u6742\u7cfb\u7edf\u3001\u7f51\u7edc\u79d1\u5b66\u3001\u8ba1\u7b97\u793e\u4f1a\u79d1\u5b66\u7b49\u9886\u57df\u7684\u524d\u6cbf\u8fdb\u5c55\u3002\u73b0\u5728\u6b63\u5f0f\u63a8\u51fa\u8ba2\u9605\u529f\u80fd\uff0c\u6bcf\u5468\u901a\u8fc7\u5fae\u4fe1\u670d\u52a1\u53f7\u300c\u6211\u7684\u96c6\u667a\u300d\u63a8\u9001\u8bba\u6587\u4fe1\u606f\u3002\u626b\u63cf\u4e0b\u65b9\u4e8c\u7ef4\u7801\u5373\u53ef\u4e00\u952e\u8ba2\u9605\uff1a<\/span>
<\/section>\n


<\/p>\n

<\/p>\n


<\/section>\n

<\/section>\n
\n

\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n