{"id":40464,"date":"2023-02-07T23:02:27","date_gmt":"2023-02-07T15:02:27","guid":{"rendered":"https:\/\/swarma.org\/?p=40464"},"modified":"2023-02-07T23:02:27","modified_gmt":"2023-02-07T15:02:27","slug":"nat-mach-intell-%e9%80%9f%e9%80%92%ef%bc%9a%e5%8f%af%e8%a7%a3%e9%87%8a%e5%8f%8c%e7%ba%bf%e6%80%a7%e6%b3%a8%e6%84%8f%e5%8a%9b%e7%bd%91%e7%bb%9c%e6%8f%90%e9%ab%98%e8%8d%af%e7%89%a9%e9%9d%b6%e7%82%b9","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=40464","title":{"rendered":"Nat. Mach. Intell. \u901f\u9012\uff1a\u53ef\u89e3\u91ca\u53cc\u7ebf\u6027\u6ce8\u610f\u529b\u7f51\u7edc\u63d0\u9ad8\u836f\u7269\u9776\u70b9\u9884\u6d4b\u80fd\u529b"},"content":{"rendered":"
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\u8bba<\/span>\u6587\u9898\u76ee\uff1a<\/span>Interpretable bilinear attention network with domain adaptation improves drug\u2013target prediction<\/span><\/section>\n
\u8bba\u6587\u6765\u6e90\uff1a<\/span>Nature Machine Intelligence<\/span><\/em><\/section>\n
\u8bba\u6587\u94fe\u63a5\uff1a<\/span>https:\/\/www.nature.com\/articles\/s42256-022-00605-1<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n


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\u4f46\u6df1\u5ea6\u5b66\u4e60\u7684\u65b9\u6cd5\u4ecd\u7136\u5b58\u5728\u4e24\u4e2a\u6311\u6218\uff1a\u5982\u4f55\u660e\u786e\u5730\u5efa\u6a21\u548c\u5b66\u4e60\u836f\u7269\u548c\u9776\u70b9\u4e4b\u95f4\u7684\u5c40\u90e8\u76f8\u4e92\u4f5c\u7528\uff0c\u4ee5\u66f4\u597d\u5730\u9884\u6d4b\u548c\u89e3\u91ca\uff1b\u7b2c\u4e8c\u4e2a\u6311\u6218\u662f\u5982\u4f55\u4f18\u5316\u5bf9\u65b0\u836f\u7269-\u9776\u70b9\u7684\u9884\u6d4b\u7684\u6cdb\u5316\u80fd\u529b\uff0c\u5373\u5728\u5df2\u77e5\u5206\u5e03\u7684\u57fa\u7840\u4e0a\uff0c\u8de8\u9886\u57df\u63a8\u5e7f\u9884\u6d4b\u6027\u80fd\u3002<\/span><\/section>\n

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\u8fd9\u7bc7\u6587\u7ae0\u63d0\u51fa\u4e86 DrugBAN\uff0c\u4e00\u4e2a\u5177\u6709\u9886\u57df\u9002\u5e94\u6027\u7684\u6df1\u5ea6\u53cc\u7ebf\u6027\u6ce8\u610f\u529b\u7f51\u7edc<\/span>\uff08bilinear attention network, BAN\uff09<\/span>\u6846\u67b6\uff0c\u4ee5\u663e\u5f0f\u5730\u5b66\u4e60\u836f\u7269\u548c\u9776\u70b9\u4e4b\u95f4\u7684\u6210\u5bf9\u5c40\u90e8\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u6839\u636e\u5206\u5e03\u5916\u6570\u636e\u8fdb\u884c\u9002\u5e94\u3002DrugBAN \u5728\u836f\u7269\u5206\u5b50\u56fe\u548c\u76ee\u6807\u86cb\u767d\u5e8f\u5217\u4e0a\u8fdb\u884c\u9884\u6d4b\uff0c\u901a\u8fc7\u6761\u4ef6\u57df\u5bf9\u6297\u6027\u5b66\u4e60\u6765\u5bf9\u9f50\u4e0d\u540c\u5206\u5e03\u4e2d\u5b66\u4e60\u5230\u7684\u4ea4\u4e92\u8868\u793a\uff0c\u4f7f\u5b66\u4e60\u5230\u7684\u76f8\u4e92\u4f5c\u7528\u8868\u5f81\u5728\u4e0d\u540c\u7684\u5206\u5e03\u4e2d\u4fdd\u6301\u4e00\u81f4\uff0c\u4ee5\u4fbf\u66f4\u597d\u5730\u6cdb\u5316\u5230\u65b0\u7684\u836f\u7269-\u9776\u70b9\u5bf9\u3002<\/span><\/section>\n

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\u5728\u4e09\u4e2a\u57fa\u51c6\u6570\u636e\u96c6\u4e0a\u8fdb\u884c\u7684\u57df\u5185\u548c\u8de8\u57df\u8bbe\u7f6e\u7684\u5b9e\u9a8c\u8868\u660e\uff0cDrugBAN \u5728\u4e0e\u4e94\u4e2a\u6700\u5148\u8fdb\u7684\u57fa\u7ebf\u6a21\u578b\u7684\u7ade\u4e89\u4e2d\u53d6\u5f97\u4e86\u6700\u4f73\u7684\u6574\u4f53\u6027\u80fd\u3002\u6b64\u5916\uff0c\u53ef\u89c6\u5316\u5b66\u4e60\u7684\u53cc\u7ebf\u6027\u6ce8\u610f\u529b\u56fe\u63d0\u4f9b\u4e86\u9884\u6d4b\u7ed3\u679c\u7684\u53ef\u89e3\u91ca\u6027\u89c1\u89e3\u3002<\/span><\/section>\n

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\u56fe1. DrugBAN \u6846\u67b6\u6982\u89c8\u3002<\/span><\/section>\n

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\u56fe2. BindingDB \u548c BioSNAP \u6570\u636e\u96c6\u7684\u8de8\u57df\u6027\u80fd\u6bd4\u8f83\u3002<\/span><\/section>\n

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\u56fe3. \u7528\u4e8e\u53ef\u89e3\u91ca\u6027\u7814\u7a76\u7684\u914d\u4f53\u548c\u7ed3\u5408\u53e3\u888b\u7684\u53ef\u89c6\u5316\u3002<\/span><\/section>\n

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