{"id":40946,"date":"2023-02-24T18:50:23","date_gmt":"2023-02-24T10:50:23","guid":{"rendered":"https:\/\/swarma.org\/?p=40946"},"modified":"2023-02-24T18:50:23","modified_gmt":"2023-02-24T10:50:23","slug":"nat-mach-intell-%e9%80%9f%e9%80%92%ef%bc%9a%e5%88%a9%e7%94%a8%e8%83%b6%e5%9b%8a%e7%bd%91%e7%bb%9c%e9%a2%84%e6%b5%8b%e5%a4%8d%e6%9d%82%e9%81%97%e4%bc%a0%e7%97%85%e7%9a%84%e6%82%a3%e7%97%85%e7%8e%87","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=40946","title":{"rendered":"Nat. Mach. Intell. \u901f\u9012\uff1a\u5229\u7528\u80f6\u56ca\u7f51\u7edc\u9884\u6d4b\u590d\u6742\u9057\u4f20\u75c5\u7684\u60a3\u75c5\u7387"},"content":{"rendered":"<div class='wxsyncmain'>\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(63, 63, 63);font-family: PingFangSC-light;font-size: 15px;background-color: rgb(255, 255, 255);visibility: visible;margin-bottom: 0px;\" data-mpa-powered-by=\"yiban.io\">\n<section style=\"outline: 0px;display: inline-block;width: 661px;vertical-align: top;background-color: rgb(246, 246, 246);visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;\">\n<p style=\"text-align: center;\"><img class=\"rich_pages wxw-img\" data-backh=\"383\" data-backw=\"578\" data-galleryid=\"104592866348679168\" data-gallerysupplier=\"1\" data-ratio=\"0.6627659574468086\" data-s=\"300,640\"  data-type=\"jpeg\" data-w=\"940\" style=\"width: 100%;height: auto;\" 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\/><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/p>\n<p style=\"text-align: left;\"><strong style=\"font-size: 13px;letter-spacing: 0.544px;text-align: justify;outline: 0px;visibility: visible;\"><strong style=\"letter-spacing: 0.544px;outline: 0px;visibility: visible;\"><strong style=\"letter-spacing: 0.544px;outline: 0px;visibility: visible;\"><strong style=\"letter-spacing: 0.544px;outline: 0px;visibility: visible;\"><strong style=\"letter-spacing: 0.544px;outline: 0px;visibility: visible;\"><strong style=\"letter-spacing: 0.544px;outline: 0px;visibility: visible;\"><strong style=\"letter-spacing: 0.544px;outline: 0px;visibility: visible;\"><strong style=\"letter-spacing: 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0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><span style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><span style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><span style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><span style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><span style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><span style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;color: rgb(0, 0, 0);text-align: start;visibility: visible;\">\u5173\u952e\u8bcd\uff1a<strong><span style=\"color: rgb(0, 0, 0);font-size: 13px;letter-spacing: 0.544px;text-decoration: none solid rgb(0, 0, 0);\">\u80f6\u56ca\u7f51\u7edc\uff0c\u5c42\u7ea7\u7ed3\u6784\uff0c\u975e\u7ebf\u6027\uff0c\u590d\u6742\u7f51\u7edc<\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;width: 661px;visibility: visible;\">\n<section style=\"outline: 0px;clear: both;line-height: 0;visibility: visible;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;visibility: visible;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align: top;visibility: visible;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(63, 63, 63);font-family: PingFangSC-light;font-size: 15px;background-color: rgb(255, 255, 255);text-align: center;visibility: visible;\">\n<section style=\"outline: 0px;vertical-align: middle;display: inline-block;line-height: 0;visibility: visible;\"><img class=\"rich_pages wxw-img\" data-fileid=\"100098753\" data-ratio=\"0.07314814814814814\"  data-type=\"png\" data-w=\"1080\" style=\"outline: 0px;box-sizing: border-box;vertical-align: middle;visibility: visible !important;width: 677px !important;height: auto !important;\" src=\"\/wp-content\/uploads\/2023\/02\/wxsync-2023-02-cb6bcab164110a8ed49c32f9502170d0.png\"  \/><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 0pt;margin-bottom: 0pt;outline: 0px;letter-spacing: 0.544px;white-space: normal;line-height: 1.7;font-family: PingFangSC-light;background-color: rgb(255, 255, 255);text-align: right;visibility: visible;\">\n<p style=\"color: rgb(73, 73, 73);outline: 0px;visibility: visible;\"><br  \/><\/p>\n<p style=\"color: rgb(73, 73, 73);\"><br  \/><\/p>\n<\/section>\n<section>\n<section><img class=\"rich_pages wxw-img\" data-backh=\"325\" data-backw=\"578\" data-height=\"521\" data-ratio=\"0.562634989200864\"  data-type=\"png\" data-w=\"926\" data-width=\"926\" style=\"white-space: normal;width: 100%;height: auto;\" src=\"\/wp-content\/uploads\/2023\/02\/wxsync-2023-02-731183ee0b493773217e10d2aa4a361f.png\"  \/><\/section>\n<\/section>\n<blockquote class=\"js_blockquote_wrap\" data-type=\"2\" data-url=\"\" data-author-name=\"\" data-content-utf8-length=\"187\" data-source-title=\"\" data-text=\"\u8bba\u6587\u9898\u76ee\uff1aCerebro-cerebellar networks facilitate learning through feedback decoupling\u8bba\u6587\u6765\u6e90\uff1aNature Communications\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41467-022-35658-8\" data-editid=\"v4qoa80lsi6vzgwf0g\">\n<section class=\"js_blockquote_digest\">\n<section>\n<section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;text-align: left;\"><span style=\"color: rgb(136, 136, 136);font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\">\u8bba\u6587\u9898\u76ee\uff1aPredicting the prevalence of complex genetic diseases from individual genotype profiles using capsule networks<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;text-align: left;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u8bba\u6587\u6765\u6e90\uff1a<em>Nature Machine Intelligence<\/em><\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;text-align: left;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s42256-022-00604-2<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;\"><br  \/><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5177\u6709\u590d\u6742\u9057\u4f20\u7ed3\u6784\u7684\u75be\u75c5\u5f80\u5f80\u4f1a\u5305\u542b\u76f8\u5f53\u6570\u91cf\u7684\u9057\u4f20\u53d8\u5f02\uff0c\u5c3d\u7ba1\u8fd9\u4e9b\u53d8\u5f02\u5728\u75be\u75c5\u4e2d\u53d1\u6325\u4e86\u4f5c\u7528\uff0c\u4f46\u4e0a\u8ff0\u53d8\u5f02\u5f80\u5f80\u672a\u88ab\u53d1\u73b0\u3002\u9020\u6210\u8fd9\u79cd\u73b0\u8c61\u7684\u4e24\u4e2a\u4e3b\u8981\u539f\u56e0\u662f\uff1a\u8fd9\u4e9b\u53d8\u5f02\u4e0d\u4f1a\u6709\u53e0\u52a0\u6548\u5e94\uff0c\u800c\u662f\u4ee5\u590d\u6742\u7684\u65b9\u5f0f\u76f8\u4e92\u4f5c\u7528\uff1b\u6b64\u5916\uff0c\u6b63\u5982\u6700\u8fd1\u63d0\u51fa\u7684\uff0c\u5168\u57fa\u56e0\u6a21\u578b<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08omnigenic\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5047\u8bbe\u53d8\u5f02\u4ee5\u6574\u4f53\u65b9\u5f0f\u76f8\u4e92\u4f5c\u7528\u4ee5\u4fc3\u6210\u75be\u75c5\u8868\u578b\u3002Nature Machine Intelligence \u7684\u8fd9\u7bc7\u6587\u7ae0\u63d0\u51fa\u75be\u75c5\u80f6\u56ca<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08DiseaseCapsule\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\uff0c\u4e00\u79cd\u80f6\u56ca\u7f51\u7edc\u4e3a\u57fa\u7840\u7684\u65b9\u6cd5\uff0c\u663e\u5f0f\u5730\u89e3\u51b3\u6355\u83b7\u57fa\u56e0\u7ec4\u6570\u636e\u4e2d\u7684\u7b49\u7ea7\u7ed3\u6784\u95ee\u9898\uff0c\u5e76\u6709\u53ef\u80fd\u5145\u5206\u6355\u83b7\u53d8\u5f02\u548c\u75be\u75c5\u4e4b\u95f4\u7684\u975e\u7ebf\u6027\u5173\u7cfb\u3002\u5f53\u4ece\u4e2a\u4f53\u57fa\u56e0\u578b\u8c31\u9884\u6d4b\u75be\u75c5\u53d1\u751f\u65f6\uff0c\u75be\u75c5\u80f6\u56ca\u662f\u7b2c\u4e00\u4e2a\u4ee5\u5168\u57fa\u56e0\u7ec4\u65b9\u5f0f\u8fdb\u884c\u64cd\u4f5c\u7684\u65b9\u6cd5\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5728\u5b9e\u9a8c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u8bc4\u4f30\u4e86\u201c\u75be\u75c5\u80f6\u56ca\u201d\u5bf9\u808c\u840e\u7f29\u6027\u5d74\u9ad3\u4fa7\u7d22\u786c\u5316\u75c7<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08ALS\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u548c\u5e15\u91d1\u68ee\u6c0f\u75c5\u7684\u4f5c\u7528\uff0c\u7279\u522b\u5173\u6ce8 ALS\uff0c\u5b83\u5df2\u77e5\u5177\u6709\u590d\u6742\u7684\u9057\u4f20\u7ed3\u6784\uff0c\u5e76\u4e14\u5448\u73b0\u51fa 40% \u7684\u9057\u4f20\u5ea6\u7f3a\u5931\u3002\u5728 ALS \u4e0a\uff0c\u75be\u75c5\u80f6\u56ca\u5728\u9884\u6d4b\u75be\u75c5\u53d1\u751f\u65b9\u9762\u8fbe\u5230\u4e86 86.9% \u7684\u51c6\u786e\u7387\uff0c\u56e0\u6b64\u5927\u5927\u4f18\u4e8e\u5176\u4ed6\u6240\u6709\u65b9\u6cd5\u3002\u6b64\u5916\uff0c\u75be\u75c5\u80f6\u56ca\u9700\u8981\u8db3\u591f\u5c11\u7684\u8bad\u7ec3\u6570\u636e\u624d\u80fd\u8fbe\u5230\u6700\u4f73\u6027\u80fd\u3002\u6700\u540e\u4f46\u5e76\u975e\u6700\u4e0d\u91cd\u8981\u7684\u662f\uff0c\u75be\u75c5\u80f6\u56ca\u53d1\u73b0\u4e86922\u4e2a\u7279\u522b\u611f\u5174\u8da3\u7684\u57fa\u56e0\uff0c\u4ee5\u53ca644\u4e2a\u201c\u975e\u52a0\u6027\u201d\u57fa\u56e0\uff0c\u8fd9\u4e9b\u57fa\u56e0\u662f\u75be\u75c5\u80f6\u56ca\u9884\u6d4b\u4e2d\u7528\u5230\u7684\u5173\u952e\u56e0\u7d20\uff0c\u4f46\u5728\u7ebf\u6027\u65b9\u6848\u4e2d\u88ab\u5ffd\u89c6\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u6574\u5408\u5168\u57fa\u56e0\u7ec4\u6570\u636e\u610f\u5473\u7740\u5904\u7406\u6570\u767e\u4e07\u7ef4\u7684\u7279\u5f81\u7a7a\u95f4\uff0c\u8fd9\u4e0e\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u591a\u6001\u4f4d\u70b9\u7684\u6570\u91cf\u76f8\u5bf9\u5e94\u3002\u8fd9\u4e9b\u57fa\u56e0\u7279\u5f02\u6027\u4e3b\u6210\u5206\u53ef\u4ee5\u4ee5\u975e\u7ebf\u6027\u65b9\u5f0f\u7ec4\u5408\uff0c\u4ee5\u53cd\u6620\u57fa\u56e0\u4e4b\u95f4\u7684\u975e\u7ebf\u6027\u76f8\u4e92\u4f5c\u7528\uff0c\u5176\u4e2d\u975e\u7ebf\u6027\u53ef\u4ee5\u8de8\u8d8a\u6574\u4e2a\u57fa\u56e0\u7ec4\u3002\u75be\u75c5\u80f6\u56ca\u6709\u4e24\u4e2a\u76f4\u63a5\u7684\u7406\u8bba\u4f18\u52bf\u3002\u9996\u5148\uff0c\u56e0\u4e3a\u5b83\u662f\u5728\u6574\u4e2a\u57fa\u56e0\u7ec4\u4e2d\u8fd0\u4f5c\u7684\uff0c\u6240\u4ee5\u75be\u75c5\u80f6\u56ca\u4e0d\u9700\u8981\u4e13\u6ce8\u4e8e\u51e0\u4e2a\u4e0e\u75be\u75c5\u76f8\u5173\u7684\u6838\u5fc3\u57fa\u56e0\uff0c\u6240\u4ee5\u5b83\u4e0d\u4f1a\u9519\u8fc7\u4e30\u5bcc\u7684\u5916\u5468\u57fa\u56e0\u7684\u5fae\u5f31\u4f5c\u7528\u3002\u5176\u6b21\uff0c\u7531\u4e8e\u80f6\u56ca\u7f51\u7edc\u80fd\u591f\u6355\u83b7\u9ad8\u5ea6\u590d\u6742\u6027\uff0c\u5728\u6355\u83b7\u57fa\u7840\u9057\u4f20\u76f8\u4e92\u4f5c\u7528\u7684\u7b49\u7ea7\u7ed3\u6784\u65b9\u9762\u6709\u6240\u6539\u8fdb\uff0c\u4f53\u73b0\u5728\u901a\u8fc7\u4f7f\u7528\u5b8c\u5168\u8fde\u63a5\u7684\u67b6\u6784\uff0c\u800c\u4e0d\u662f\u5c06\u5377\u79ef\u5c42\u4f5c\u4e3a\u80f6\u56ca\u7f51\u7edc\u7684\u65e9\u671f\u5c42\u3002\u53ef\u4ee5\u6700\u5927\u9650\u5ea6\u5730\u6355\u83b7\u6574\u4e2a\u57fa\u56e0\u7ec4\u4e2d\u57fa\u56e0\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u5bf9\u8f93\u5165\u6570\u636e\u7684\u987a\u5e8f\u81ea\u9002\u5e94\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u75be\u75c5\u80f6\u56ca\u7684\u8868\u73b0\u4f18\u4e8e\u6240\u6709\u6700\u5148\u8fdb\u7684\u65b9\u6cd5: \u5728\u6d4b\u8bd5\u6570\u636e\u4e0a\u7684\u51c6\u786e\u7387\u8fbe\u5230\u4e8687% \u3002\u8fd9\u610f\u5473\u7740\u6bd4 PRS \u76f8\u5bf9\u589e\u52a0\u4e8628%\u7684\u9519\u8bef\u5206\u7c7b\u3002\u8be5\u65b9\u6cd5\u8fd8\u5151\u73b0\u4e86\u5176\u5728\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u5e94\u7528\u7684\u4e24\u4e2a\u4e3b\u8981\u7406\u8bba\u627f\u8bfa: \u53ef\u6301\u7eed\u5730\u8f93\u5165\u8bad\u7ec3\u6570\u636e\uff0c\u8fd9\u5728\u63d0\u9ad8\u4e34\u5e8a\u6570\u636e\u65f6\u964d\u4f4e\u4e86\u6210\u672c\u548c\u52aa\u529b\uff0c\u4ee5\u53ca\u5728\u9884\u6d4b\u7684\u53ef\u89e3\u91ca\u6027\u65b9\u9762\u53d6\u5f97\u8fdb\u6b65\uff0c\u8868\u73b0\u5c31\u662f\u63ed\u793a\u4e86922\u4e2a\u4e0e ALS \u76f8\u5173\u7684\u5019\u9009\u57fa\u56e0\uff0c\u5176\u4e2d\u8bb8\u591a\u5728\u9075\u5faa\u6807\u51c6 GWAS \u65b9\u6848\u65f6\u6ca1\u6709\u88ab\u6307\u51fa\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;text-align: center;\"><img class=\"rich_pages wxw-img\" data-height=\"368\" data-ratio=\"0.5372262773722628\"  data-type=\"png\" data-w=\"685\" data-width=\"685\" src=\"\/wp-content\/uploads\/2023\/02\/wxsync-2023-02-e763a631321de303a9dba2597a805bd1.png\"  \/><\/section>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.5em;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">\u56fe1. \u75be\u75c5\u80f6\u56ca\u7684\u8fd0\u4f5c\u6d41\u7a0b\uff0c\u57fa\u4e8e\u6765\u81ea4\u4e2a\u6279\u6b21\u768410456\u4e2a\u5168\u57fa\u56e0\u6570\u636e\uff0c\u7ecf\u8fc7\u8d28\u63a7\uff0c\u6279\u6b21\u6548\u5e94\u53bb\u9664\uff0c\u9009\u51fa\u5408\u90024.3M\u4e2aSNP\uff0c\u4e4b\u540e\u5206\u4e3a\u6d4b\u8bd5\u548c\u8bad\u7ec3\u6570\u636e\u96c6\uff0c\u901a\u8fc7 PCA \u964d\u7ef4\uff0c\u5c06\u964d\u7ef4\u540e\u7684\u7ed3\u679c\u7ecf\u7531\u80f6\u56ca\u7f51\u7edc\u5f97\u5230\u5206\u7c7b\u7ed3\u679c\u3002<\/span><\/p>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;text-align: center;\"><img class=\"rich_pages wxw-img\" data-height=\"392\" data-ratio=\"0.5722627737226277\"  data-type=\"png\" data-w=\"685\" data-width=\"685\" src=\"\/wp-content\/uploads\/2023\/02\/wxsync-2023-02-e5f11562c180cdb2f8df5cbd3a814667.png\"  \/><\/section>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.5em;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">\u56fe2. \u75be\u75c5\u80f6\u56ca\u7684\u7f51\u7edc\u67b6\u6784\uff0c\u8f93\u5165\u662f\u6765\u81ea\u6240\u6709 Gene-PCA \u6a21\u578b\u7684\u538b\u7f29\u7279\u5f81\u5411\u91cf\uff0c\u5176\u4e2d\u6bcf\u4e2a\u7279\u5f81\u5bf9\u5e94\u4e8e\u4e00\u4e2a Gene-PCA\u3002\u57fa\u56e0\u4e3b\u6210\u5206\u5206\u6790\u7684\u6570\u91cf\u4e3a 75,584\uff0c\u56e0\u6b64\u8f93\u5165\u7ef4\u6570\u4e3a 75,584 \u00d7 1\u3002\u75be\u75c5\u80f6\u56ca\u7531\u4e09\u5c42\u7ec4\u6210: \u5b8c\u5168\u8fde\u63a5\u5c42(FC)\u3001\u521d\u7ea7\u80f6\u56ca\u5c42 (PrimaryCaps) \u548c\u8868\u578b\u80f6\u56ca\u5c42 (phenoCaps)\u3002FC \u5c42\u7531150\u4e2a\u795e\u7ecf\u5143\u7ec4\u6210\uff0c\u5176\u6b21\u662f\u6fc0\u6d3b\u51fd\u6570\u3002PrimaryCaps \u753132\u4e2a\u4e3b\u80f6\u56ca\u7ec4\u6210\u3002\u5b83\u4eec\u6bcf\u4e2a\u90fd\u5305\u542b\u56db\u4e2a\u4e0d\u540c\u7684\u5377\u79ef\u6ee4\u6ce2\u5668(\u5185\u6838\u5927\u5c0f5 \u00d7 1\uff0c\u6b65\u957f2\uff0c\u65e0\u586b\u5145)\u3002\u8868\u578b\u80f6\u56ca\u7531\u4e24\u4e2a16\u7ef4\u5411\u91cf\u7ec4\u6210\u3002\u6bcf\u4e2a\u8868\u578b\u80f6\u56ca\u63a5\u53d7\u6765\u81ea\u6240\u670932\u4e2a\u521d\u7ea7\u80f6\u56ca\u7684\u8f93\u5165\u3002\u8f93\u51fa\u662f\u4e00\u4e2a\u4e8c\u5143\u5206\u7c7b\u6807\u7b7e(\u5065\u5eb7\u6216 ALS)\u3002<\/span><\/p>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;text-align: center;\"><img class=\"rich_pages wxw-img\" data-height=\"395\" data-ratio=\"0.5766423357664233\"  data-type=\"png\" data-w=\"685\" data-width=\"685\" src=\"\/wp-content\/uploads\/2023\/02\/wxsync-2023-02-c0e9582fbcdcaadad7ed5a5b8d9534a5.png\"  \/><\/section>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.5em;\"><span style=\"color: rgb(136, 136, 136);font-size: 13px;\">\u56fe3. \u521d\u7ea7\u80f6\u56ca\u4e0e\u8868\u578b\u80f6\u56ca\u5728ALS\u4e0a\u6240\u6709\u57fa\u56e0\u4e2d\u7684\u7684\u5076\u8054\u7cfb\u6570\u5206\u5e03\u3002\u7ea2\u8272\u865a\u7ebf\u8868\u793a95%\u767e\u5206\u4f4d\u3002\u4ee5\u4e0a922\u4e2a\u57fa\u56e0\u4f5c\u4e3a\u5206\u7c7b\u7684\u51b3\u5b9a\u6027\u6838\u5fc3\u57fa\u56e0\u3002B\uff0c\u4f7f\u7528922\u4e2a\u968f\u673a\u9009\u62e9\u7684\u57fa\u56e0\u4f5c\u4e3a\u75be\u75c5\u80f6\u56ca\u6a21\u578b\u7684\u8f93\u5165(\u91cd\u590d1,000\u6b21) \uff0c\u800c\u5176\u4ed6\u57fa\u56e0\u88ab\u63a9\u76d6(\u8bbe\u7f6e\u4e3a\u96f6)\u7684\u6d4b\u8bd5\u51c6\u786e\u6027\u5206\u5e03\u3002\u7ea2\u8272\u865a\u7ebf\u8868\u793a\u4f7f\u7528922\u4e2a\u6838\u5fc3\u57fa\u56e0\u4f5c\u4e3a\u8f93\u5165\u7684\u6d4b\u8bd5\u51c6\u786e\u6027\u3002C\uff0c\u4ee5922\u4e2a\u6838\u5fc3\u57fa\u56e0\u4e3a\u8f93\u5165\u7684\u5e73\u5747\u8026\u5408\u7cfb\u6570\u77e9\u9635\u70ed\u56fe(\u6d4b\u8bd5\u6570\u636e)\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;white-space: normal;line-height: 1.75em;\"><br  \/><\/p>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;color: rgb(34, 34, 34);font-family: system-ui, -apple-system, &quot;system-ui&quot;, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);\"><br style=\"outline: 0px;\"  \/><\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);text-align: center;justify-content: center;\">\n<section style=\"outline: 0px;display: inline-block;width: auto;vertical-align: top;min-width: 10%;height: auto;box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-bottom: 9px solid rgb(169, 215, 227);border-bottom-right-radius: 0px;\">\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: -15px;outline: 0px;\">\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;color: rgb(12, 130, 169);font-size: 16px;line-height: 2;letter-spacing: 3px;\">\n<p style=\"outline: 0px;\"><strong style=\"outline: 0px;\">\u9ad8\u9636\u7f51\u7edc\u793e\u533a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 0em;margin-left: 8px;outline: 0px;color: rgb(34, 34, 34);font-family: system-ui, -apple-system, &quot;system-ui&quot;, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247620326&amp;idx=1&amp;sn=ed699ca7e5b2991a62d7eaccdffae4f5&amp;chksm=e8964c6bdfe1c57df8712fec1efae9dc4be030a7119e6562283d33abeeb0f17a958fd6a7a33f&amp;scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" wah-hotarea=\"click\" 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textvalue=\"319\u7bc7\u6587\u732e\u300141\u9875\u7efc\u8ff0\u6587\u7ae0\u8bb2\u8ff0\u56fe\u795e\u7ecf\u7f51\u7edc\u7528\u4e8e\u533b\u7597\u8bca\u65ad\u7684\u524d\u4e16\u4eca\u751f\u4e0e\u672a\u6765\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"11\" tab=\"innerlink\" style=\"text-decoration: underline;\" data-linktype=\"2\" rel=\"noopener noreferrer\">319\u7bc7\u6587\u732e\u300141\u9875\u7efc\u8ff0\u6587\u7ae0\u8bb2\u8ff0\u56fe\u795e\u7ecf\u7f51\u7edc\u7528\u4e8e\u533b\u7597\u8bca\u65ad\u7684\u524d\u4e16\u4eca\u751f\u4e0e\u672a\u6765<\/a><\/section>\n<\/li>\n<li style=\"margin: 0px;padding: 0px;clear: both;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;outline: 0px;font-weight: bold;\">\n<section style=\"margin: 0px 8px 10px;padding: 0px;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;outline: 0px;\"><a target=\"_blank\" 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0px;max-width: 100%;overflow-wrap: break-word !important;box-sizing: border-box !important;\"><br  \/><\/section>\n<\/section>\n<section style=\"outline: currentcolor none 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;background-color: rgb(255, 255, 255);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;margin-bottom: 0px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;font-size: 15px;text-align: left;color: rgb(255, 255, 255);font-family: PingFangSC-light;\"><span style=\"outline: 0px;background-color: rgb(12, 130, 169);\">\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<strong style=\"outline: 0px;letter-spacing: 0.544px;white-space: normal;font-size: 15px;text-align: left;color: rgb(255, 255, 255);font-family: PingFangSC-light;\"><\/strong><\/span><\/strong><\/section>\n<p style=\"display: none;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5173\u952e\u8bcd\uff1a\u80f6\u56ca\u7f51\u7edc\uff0c\u5c42\u7ea7\u7ed3\u6784\uff0c\u975e\u7ebf\u6027\uff0c\u590d\u6742\u7f51\u7edc \u8bba\u6587\u9898\u76ee\uff1aPredicting the prevalence of complex genetic diseases from individual genotype profiles using capsule networks \u8bba\u6587\u6765\u6e90\uff1aNature&#8230;<\/p>\n","protected":false},"author":0,"featured_media":40940,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/40946"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=40946"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/40946\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/40940"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=40946"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=40946"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=40946"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=40946"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}