{"id":41026,"date":"2023-03-04T22:17:05","date_gmt":"2023-03-04T14:17:05","guid":{"rendered":"https:\/\/swarma.org\/?p=41026"},"modified":"2023-03-04T22:17:05","modified_gmt":"2023-03-04T14:17:05","slug":"nat-commun-%e9%80%9f%e9%80%92%ef%bc%9a%e5%9f%ba%e4%ba%8e%e5%bc%82%e8%b4%a8%e5%9b%be-transformer-%e7%9a%84%e5%8d%95%e7%bb%86%e8%83%9e%e7%94%9f%e7%89%a9%e7%bd%91%e7%bb%9c%e6%8e%a8%e7%90%86","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=41026","title":{"rendered":"Nat. Commun. \u901f\u9012\uff1a\u57fa\u4e8e\u5f02\u8d28\u56fe transformer \u7684\u5355\u7ec6\u80de\u751f\u7269\u7f51\u7edc\u63a8\u7406"},"content":{"rendered":"
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\u8bba\u6587\u9898\u76ee\uff1aSingle-cell biological network inference using a heterogeneous graph transformer<\/span><\/section>\n

\u8bba\u6587\u6765\u6e90\uff1aNature Communications<\/em><\/span><\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41467-023-36559-0<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n


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\u5355\u7ec6\u80de\u591a\u7ec4\u5b66<\/span>\uff08Single-cell multi-omics, scMulti-omics\uff09<\/span>\u5141\u8bb8\u540c\u65f6\u5bf9\u591a\u79cd\u7ec4\u5b66\u6570\u636e\u8fdb\u884c\u5b9a\u91cf\u5206\u6790\uff0c\u4ee5\u6355\u6349\u590d\u6742\u7684\u5206\u5b50\u673a\u5236\u548c\u7ec6\u80de\u5f02\u8d28\u6027\u7684\u590d\u6742\u6027\u3002\u73b0\u6709\u7684\u5de5\u5177\u4e0d\u80fd\u6709\u6548\u5730\u63a8\u65ad\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7684\u6d3b\u6027\u751f\u7269\u7f51\u7edc\u4ee5\u53ca\u8fd9\u4e9b\u7f51\u7edc\u5bf9\u5916\u90e8\u523a\u6fc0\u7684\u53cd\u5e94\u3002<\/span><\/p>\n


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Nature Communications<\/span><\/em> \u7684\u8fd9\u9879\u7814\u7a76\u63d0\u51fa\u4e86\u5229\u7528\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u6570\u636e\u8fdb\u884c\u751f\u7269\u7f51\u7edc\u63a8\u7406\u7684\u7b97\u6cd5\u67b6\u6784 DeepMAPS\u3002\u5b83\u5728\u4e00\u4e2a\u5f02\u6784\u56fe\u4e2d\u5bf9\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u6570\u636e\u5efa\u6a21\uff0c\u5e76\u4f7f\u7528\u4e00\u4e2a multi-head graph transformer<\/span>\uff08HGT\uff09<\/span>\u5728\u5c40\u90e8\u548c\u5168\u5c40\u4e0a\u4e0b\u6587\u4e2d\u4ee5\u4e00\u79cd\u9c81\u68d2\u7684\u65b9\u5f0f\u5b66\u4e60\u7ec6\u80de\u548c\u57fa\u56e0\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u57fa\u51c6\u6d4b\u8bd5\u7ed3\u679c\u8868\u660e\uff0cDeepMAPS \u5728\u7ec6\u80de\u805a\u7c7b\u548c\u751f\u7269\u7f51\u7edc\u6784\u5efa\u65b9\u9762\u7684\u8868\u73b0\u4f18\u4e8e\u73b0\u6709\u5de5\u5177\u3002\u5b83\u8fd8\u5c55\u793a\u4e86\u5728\u80ba\u80bf\u7624\u767d\u7ec6\u80de CITE-seq \u6570\u636e\u548c\u5339\u914d\u7684\u5f25\u6f2b\u6027\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u5355\u7ec6\u80de RNA \u548c\u5355\u7ec6\u80de ATAC \u6570\u636e\u4e2d\u63a8\u5bfc\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u751f\u7269\u7f51\u7edc\u4e0a\uff0c\u8868\u73b0\u4f18\u4e8e\u5176\u4ed6\u5de5\u5177\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u90e8\u7f72\u4e86\u4e00\u4e2a\u53ef\u63d0\u4f9b\u591a\u79cd\u529f\u80fd\u548c\u53ef\u89c6\u5316\u7684 DeepMAPS \u7f51\u7edc\u670d\u52a1\uff0c\u4ee5\u63d0\u9ad8\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u6570\u636e\u5206\u6790\u7684\u53ef\u7528\u6027\u548c\u53ef\u91cd\u590d\u6027\u3002<\/span><\/p>\n


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\u56fe1. DeepMAPS \u7684\u603b\u4f53\u6846\u67b6\u3002\u4ece\u8f93\u5165\u7684\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u6570\u636e\u8fdb\u884c\u7ec6\u80de\u805a\u7c7b\u548c\u751f\u7269\u57fa\u56e0\u7f51\u7edc\u63a8\u65ad\uff0c\u4e3b\u8981\u5305\u62ec\u4e94\u4e2a\u6b65\u9aa4\u3002B \u56fe\u81ea\u7f16\u7801\u5668\u7ed3\u5408 HGT\uff08\u5f02\u6784\u56fe transformer\uff09 \u6a21\u578b\u3002\u5229\u7528\u6574\u5408\u540e\u7684\u7ec6\u80de-\u57fa\u56e0\u77e9\u9635\u6784\u5efa\u4e86\u5305\u542b\u6240\u6709\u7ec6\u80de(\u7eff\u8272)\u548c\u57fa\u56e0(\u7d2b\u8272)\u7684\u5f02\u8d28\u56fe\u3002HGT \u6a21\u578b\u5728\u591a\u4e2a\u5b50\u56fe\uff08\u4ee550\u4e2a\u5b50\u56fe\u4e3a\u4f8b\uff09\u4e0a\u8fdb\u884c\u8bad\u7ec3\uff0c\u5c3d\u53ef\u80fd\u591a\u5730\u8986\u76d6\u6574\u4e2a\u56fe\u4e2d\u7684\u8282\u70b9\u3002\u6bcf\u4e2a\u5b50\u56fe\u6a21\u578b\u88ab\u8bad\u7ec3100\u8f6e\uff1b\u56e0\u6b64\uff0c\u6574\u4e2a\u8bad\u7ec3\u8fc7\u7a0b\u8fed\u4ee35000\u6b21\u3002\u7136\u540e\u5c06\u8bad\u7ec3\u597d\u7684\u6a21\u578b\u5e94\u7528\u5230\u6574\u4e2a\u56fe\u4e2d\uff0c\u5b66\u4e60\u548c\u66f4\u65b0\u6bcf\u4e2a\u8282\u70b9\u7684\u5d4c\u5165\u3002\u5728\u4e00\u4e2a HGT \u5c42\u4e2d\u5d4c\u5165\u76ee\u6807\u8282\u70b9\u7684\u66f4\u65b0\u8fc7\u7a0b\u3002\u4e0a\u9762\u9762\u677f\u4e2d\u7684\u7ea2\u8272\u5706\u5708\u8868\u793a\u76ee\u6807\u8282\u70b9\uff0c\u9ed1\u8272\u5706\u5708\u8868\u793a\u6e90\u8282\u70b9\u3002\u7bad\u5934\u8868\u793a\u76ee\u6807\u8282\u70b9\u548c\u6e90\u8282\u70b9\u4e4b\u95f4\u7684\u8fde\u63a5\u3002\u5f69\u8272\u77e9\u5f62\u8868\u793a\u4e0d\u540c\u8282\u70b9\u7684\u5d4c\u5165\u3002\u5728\u5e95\u90e8\u56fe\u7684\u653e\u5927\u8be6\u7ec6\u8fc7\u7a0b\u663e\u793a\u4fe1\u606f\u4f20\u9012\u8fc7\u7a0b\u548c\u6ce8\u610f\u529b\u673a\u5236\u3002\u4e00\u4e2a HGT \u5c42\u7684\u6700\u7ec8\u8f93\u51fa\u662f\u6240\u6709\u8282\u70b9\u7684\u8282\u70b9\u5d4c\u5165\u66f4\u65b0\u3002<\/span><\/section>\n


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\u56fe2. DeepMAPS \u5728\u7ec6\u80de\u805a\u7c7b\u4e0a\u7684\u8868\u73b0\u8bc4\u4ef7<\/span><\/p>\n


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\u56fe3. \u5728\u57fa\u56e0\u5173\u8054\u7f51\u7edc\u63a8\u65ad\u4efb\u52a1\u4e0a\uff0cDeepMAPS\u7684\u6027\u80fd\u8bc4\u4ef7\u53ca\u548c\u5176\u4ed6\u65b9\u6cd5\u7684\u5bf9\u6bd4<\/span><\/p>\n

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\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n

1. <\/strong>\u7814\u7a76\u901f\u9012\uff1a\u56fe\u795e\u7ecf\u7f51\u7edc\u9884\u6d4b\u590d\u6742\u7f51\u7edc\u4e2d\u7684\u4f20\u64ad\u73b0\u8c61<\/a><\/strong><\/span><\/strong><\/section>\n
2. <\/strong>319\u7bc7\u6587\u732e\u300141\u9875\u7efc\u8ff0\u6587\u7ae0\u8bb2\u8ff0\u56fe\u795e\u7ecf\u7f51\u7edc\u7528\u4e8e\u533b\u7597\u8bca\u65ad\u7684\u524d\u4e16\u4eca\u751f\u4e0e\u672a\u6765<\/a><\/strong><\/span><\/strong><\/section>\n
3. <\/strong><\/strong>\u957f\u6587\u7efc\u8ff0\uff1a\u56fe\u795e\u7ecf\u7f51\u7edc\u7684\u53ef\u89e3\u91ca\u6027<\/a><\/strong><\/strong><\/span><\/strong><\/strong><\/section>\n
4. \u300a\u5f20\u6c5f\u00b7\u590d\u6742\u79d1\u5b66\u524d\u6cbf27\u8bb2\u300b\u5b8c\u6574\u4e0a\u7ebf\uff01<\/strong><\/a><\/strong><\/strong><\/strong><\/section>\n
5. \u6210\u4e3a\u96c6\u667aVIP\uff0c\u89e3\u9501\u5168\u7ad9\u8bfe\u7a0b\uff0f\u8bfb\u4e66\u4f1a<\/span><\/strong><\/a><\/strong><\/strong><\/strong><\/strong><\/section>\n
6. \u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/a><\/strong><\/strong><\/strong><\/section>\n

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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/strong><\/strong><\/span><\/strong><\/section>\n

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\u5173\u952e\u8bcd\uff1a\u751f\u7269\u7f51\u7edc\uff0c\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\uff0c\u56fe\u795e\u7ecf\u7f51\u7edc\uff0c\u673a\u5668\u5b66\u4e60 \u8bba\u6587\u9898\u76ee\uff1aSingle-cell biological network inference using a heterogeneous graph transformer \u8bba\u6587\u6765\u6e90\uff1aNature Communications \u8bba\u6587\u94fe\u63a5\uff1ahttps…<\/p>\n","protected":false},"author":0,"featured_media":41019,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/41026"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=41026"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/41026\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/41019"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=41026"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=41026"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=41026"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=41026"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}