{"id":41059,"date":"2023-03-06T20:22:34","date_gmt":"2023-03-06T12:22:34","guid":{"rendered":"https:\/\/swarma.org\/?p=41059"},"modified":"2023-03-06T20:22:34","modified_gmt":"2023-03-06T12:22:34","slug":"sci-adv-%e9%80%9f%e9%80%92%ef%bc%9a%e7%bb%93%e6%9e%84%e5%b7%b2%e7%9f%a5%e5%be%ae%e7%94%9f%e7%89%a9%e7%be%a4%e8%90%bd%e5%9f%ba%e5%9b%a0%e6%8f%ad%e7%a4%ba%e5%a1%91%e9%80%a0%e8%9b%8b%e7%99%bd%e8%b4%a8","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=41059","title":{"rendered":"Sci. Adv. \u901f\u9012\uff1a\u7ed3\u6784\u5df2\u77e5\u5fae\u751f\u7269\u7fa4\u843d\u57fa\u56e0\u63ed\u793a\u5851\u9020\u86cb\u767d\u8d28\u6f14\u5316\u7684\u9009\u62e9\u538b\u529b"},"content":{"rendered":"
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\u8bba\u6587\u9898\u76ee\uff1aStructure-informed microbial population genetics elucidate selective pressures that shape protein evolution<\/span><\/section>\n

\u8bba\u6587\u6765\u6e90\uff1aScience Advances<\/em><\/span><\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.science.org\/doi\/10.1126\/sciadv.abq4632<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n


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\u8fd1\u65e5\u53d1\u8868\u4e8e Science Advances<\/em> \u7684\u8fd9\u7bc7\u6587\u7ae0\uff0c\u63cf\u8ff0\u4e86\u4e00\u79cd\u5728\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u80cc\u666f\u4e0b\u5206\u6790\u9057\u4f20\u53d8\u5f02\u7684\u65b9\u6cd5\uff0c\u5e76\u5c06\u5176\u5e94\u7528\u4e8eSAR11\u4e9a\u5206\u652f1a.3.V\u4e2d\u7684\u6d77\u6d0b\u5fae\u751f\u7269\u79cd\u7fa4\u4e0a\u3002\u8fd9\u4e2a\u5fae\u751f\u7269\u79cd\u7fa4\u5e7f\u6cdb\u5b58\u5728\u4e8e\u4f4e\u7eac\u5ea6\u6d77\u6d0b\u8868\u9762\u3002\u6587\u7ae0\u5206\u6790\u63ed\u793a\u4e86\u9057\u4f20\u53d8\u5f02\u548c\u86cb\u767d\u8d28\u7ed3\u6784\u4e4b\u95f4\u7684\u7d27\u5bc6\u8054\u7cfb\u3002\u5728\u6c2e\u4ee3\u8c22\u7684\u4e00\u4e2a\u4e2d\u5fc3\u57fa\u56e0\u4e2d\u89c2\u5bdf\u5230\uff0c\u6765\u81ea\u914d\u4f53\u7ed3\u5408\u4f4d\u70b9\u7684\u975e\u540c\u4e49\u53d8\u4f53<\/span>\uff08nonsynonymous variants\uff09<\/span>\u7684\u51cf\u5c11\u662f\u785d\u9178\u76d0\u6d53\u5ea6\u7684\u51fd\u6570\u3002\u8fd9\u63ed\u793a\u4e86\u7531\u8425\u517b\u53ef\u83b7\u5f97\u6027\u7ef4\u6301\u7684\u4e0d\u540c\u8fdb\u5316\u538b\u529b\u7684\u9057\u4f20\u9776\u70b9\u3002\u8fd9\u7bc7\u5de5\u4f5c\u5bf9\u8fdb\u5316\u7684\u539f\u5219\u6709\u7740\u6df1\u523b\u7684\u89c1\u89e3\uff0c\u4e3a\u5fae\u751f\u7269\u79cd\u7fa4\u9057\u4f20\u5b66\u7684\u7ed3\u6784\u611f\u77e5\u7814\u7a76\u6253\u4e0b\u57fa\u7840\u3002<\/span><\/p>\n


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\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n

1. <\/strong>Nat. Struct. | \u65e8\u5728\u89e3\u6790\u4eba\u7c7b\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7ed3\u6784\u7684\u7f51\u7edc<\/a><\/strong><\/span><\/strong><\/section>\n
2. <\/strong>\u89c1\u8457\u77e5\u5fae\u2014\u2014\u5fae\u751f\u7269\u751f\u6001\u7cfb\u7edf\u6f14\u5316\u7c97\u7c92\u5316\u6a21\u578b<\/a><\/strong><\/span><\/strong><\/section>\n
3. <\/strong><\/strong>\u524d\u6cbf\u901f\u9012\uff1a\u6d8c\u73b0\u89c6\u89d2\u7684\u5fae\u751f\u7269\u751f\u6001\u7cfb\u7edf\u5efa\u6a21\u65b9\u6cd5<\/a><\/strong><\/strong><\/span><\/strong><\/strong><\/section>\n
4. \u300a\u5f20\u6c5f\u00b7\u590d\u6742\u79d1\u5b66\u524d\u6cbf27\u8bb2\u300b\u5b8c\u6574\u4e0a\u7ebf\uff01<\/strong><\/a><\/strong><\/strong><\/strong><\/section>\n
5. \u6210\u4e3a\u96c6\u667aVIP\uff0c\u89e3\u9501\u5168\u7ad9\u8bfe\u7a0b\uff0f\u8bfb\u4e66\u4f1a<\/span><\/strong><\/a><\/strong><\/strong><\/strong><\/strong><\/section>\n
6. \u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/a><\/strong><\/strong><\/strong><\/section>\n


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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/strong><\/strong><\/span><\/strong><\/section>\n

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\u5173\u952e\u8bcd\uff1a\u6f14\u5316\uff0c\u57fa\u56e0\u53d8\u5f02\uff0c\u86cb\u767d\u8d28\u7ed3\u6784\u6f14\u5316\uff0c\u9009\u62e9\u538b\u529b \u8bba\u6587\u9898\u76ee\uff1aStructure-informed microbial population genetics elucidate selective pressures that shape protein evolution \u8bba\u6587\u6765\u6e90\uff1aScience…<\/p>\n","protected":false},"author":0,"featured_media":41052,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/41059"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=41059"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/41059\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/41052"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=41059"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=41059"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=41059"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=41059"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}