{"id":41595,"date":"2023-04-06T16:43:09","date_gmt":"2023-04-06T08:43:09","guid":{"rendered":"https:\/\/swarma.org\/?p=41595"},"modified":"2023-04-06T16:43:09","modified_gmt":"2023-04-06T08:43:09","slug":"%e7%a5%9e%e7%bb%8f%e5%8a%a8%e5%8a%9b%e5%ad%a6%e6%a8%a1%e5%9e%8b%e6%96%b0%e8%bf%9b%e5%b1%95%ef%bc%9a%e7%a5%9e%e7%bb%8f%e5%85%83%e8%87%aa%e6%88%91%e8%b0%83%e8%8a%82%e5%a2%9e%e5%8a%a0%e4%bf%a1%e6%81%af","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=41595","title":{"rendered":"\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u65b0\u8fdb\u5c55\uff1a\u795e\u7ecf\u5143\u81ea\u6211\u8c03\u8282\u589e\u52a0\u4fe1\u606f\u4f20\u9012\u53ef\u9760\u6027"},"content":{"rendered":"
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\u8fd1\u65e5\uff0c\u7f8e\u56fd Brandeis \u5927\u5b66\u81e7\u8574\u4eae\u535a\u58eb\u53ca\u5408\u4f5c\u8005\u5728 Cell \u65d7\u4e0b\u671f\u520a Current Biology<\/em> \u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u63d0\u51fa\u4e00\u79cd\u7ef4\u6301\u795e\u7ecf\u7cfb\u7edf\u7a33\u5b9a\u6027\u7684\u751f\u7269\u673a\u5236\uff1a\u795e\u7ecf\u5143\u901a\u8fc7\u8c03\u8282\u79bb\u5b50\u901a\u9053\u53ef\u83b7\u6027\uff08availability\uff09\u6765\u589e\u52a0\u8109\u51b2\u4fe1\u606f\u6fc0\u53d1\u548c\u4f20\u5bfc\u53ef\u9760\u6027\u3002\u8fd9\u53ef\u4ee5\u4f5c\u4e3a\u7ef4\u6301\u795e\u7ecf\u7cfb\u7edf\u6b63\u5e38\u4ee5\u53ca\u75be\u75c5\u72b6\u6001\u4e0b\u7684\u81ea\u6211\u4fdd\u62a4\u673a\u5236\u3002<\/span><\/strong><\/span><\/strong><\/span><\/strong><\/p>\n


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\u8bba\u6587\u9898\u76ee\uff1aSodium channel slow inactivation normalizes firing in axons with uneven conductance distributions<\/span><\/section>\n
\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.cell.com\/current-biology\/fulltext\/S0960-9822(23)00331-7<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n<\/section>\n

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\u56fe2. \u94a0\u79bb\u5b50\u6162\u5931\u6d3b\u95e8\u7279\u6027\u3002Hodgkin-Huxley\u6a21\u578b\u4e2d\u53ea\u5305\u542b\u5feb\u901f\u5931\u6d3b\u95e8\uff0c\u4e5f\u5c31\u662f\u5931\u6d3b\u79bb\u5b50\u5feb\u901f\u6062\u590d\u5230\u53ef\u83b7\u6001\u3002\u4f46\u662f\u94a0\u79bb\u5b50\u8fd8\u5b58\u5728\u6162\u901f\u5931\u6d3b\u6001\uff08\u89c1\u4e0a\u56fe\uff09\uff0c\u5176\u52a8\u529b\u5b66\u7279\u6027\u5305\u62ec\u7a33\u6001\u5931\u6d3b\u66f2\u7ebf\uff08\u5982\u4e0b\u56fe\u5de6\uff09\u4ee5\u53ca\u5931\u6d3b\uff08\u5982\u4e0b\u56fe\u53f3\uff0c\u9ad8\u7535\u538b\u8303\u56f4\u6240\u793a\uff09\u548c\u6062\u590d\uff08\u5982\u4e0b\u56fe\u53f3\uff0c\u4f4e\u7535\u538b\u8303\u56f4\u6240\u793a\uff09\u7684\u65f6\u95f4\u5e38\u6570\u3002<\/span><\/p>\n


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\u672c\u6587\u63a2\u7d22\u4e86\u94a0\u79bb\u5b50\u6162\u5931\u6d3b<\/span>\uff08\u6062\u590d\uff09<\/span>\u95e8\u5bf9\u7ef4\u6301\u4fe1\u606f\u7a33\u5b9a\u4f20\u5bfc\u7684\u91cd\u8981\u4f5c\u7528\uff0c\u5b83\u53ef\u4ee5\u4f5c\u4e3a\u7ef4\u6301\u795e\u7ecf\u7cfb\u7edf\u6b63\u5e38\u4ee5\u53ca\u75be\u75c5\u72b6\u6001\u4e0b\u7684\u81ea\u6211\u4fdd\u62a4\u673a\u5236\u3002\u76f8\u8f83\u4e8e\u57fa\u4e8e\u7845\u6750\u6599\u6784\u5efa\u7684\u786c\u4ef6\u7cfb\u7edf\uff0c\u751f\u7269\u7cfb\u7edf\u5177\u6709\u66f4\u591a\u7684\u4e0d\u786e\u5b9a\u6027\uff0c\u4f46\u5176\u81ea\u8eab\u7684\u53ef\u8c03\u8282\u6027\u4e5f\u66f4\u5177\u521b\u9020\u6027\u3002<\/span>
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1. Zang, Y., and Marder, E. (2021). Interactions among diameter, myelination, and the Na\/K pump affect axonal resilience to high-frequency spiking. Proc. Natl. Acad. Sci. U S A 118, e2105795118. 10.1073\/pnas.2105795118.<\/span><\/section>\n
2. Zang, Y., and Marder, E. (2023). Neuronal morphology enhances robustness to perturbations of channel densities. Proc. Natl. Acad. Sci. U S A 120, e2219049120.<\/span><\/section>\n
3. Zang, Y., Marder, E., and Marom, S. (2023). Sodium channel slow inactivation normalizes firing in axons with uneven conductance distributions. Curr. Biol. 33, 1-7. 10.1016\/j.cub.2023.03.043.<\/span><\/section>\n
4. Hodgkin, A.L., and Huxley, A.F. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol 117, 500-544. 10.1113\/jphysiol.1952.sp004764.<\/span><\/section>\n
5. O’Leary, T., Williams, A.H., Franci, A., and Marder, E. (2014). Cell types, network homeostasis, and pathological compensation from a biologically plausible ion channel expression model. Neuron 82, 809-821. 10.1016\/j.neuron.2014.04.002.<\/span><\/section>\n
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\u795e\u7ecf\u52a8\u529b\u5b66\u6a21\u578b\u8bfb\u4e66\u4f1a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span>
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\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n

1. <\/strong>PNAS\u65b0\u7814\u7a76\u63ed\u793a\u795e\u7ecf\u7cfb\u7edf\u6297\u566a\u80fd\u529b\u4ece\u4f55\u800c\u6765<\/a><\/strong><\/span><\/section>\n
2. <\/strong>Nat. Commun. \u901f\u9012\uff1a\u5f15\u5165\u6811\u7a81\u72b6\u7ed3\u6784\uff0c\u5c06\u6811\u7a81\u7ed3\u6784\u6574\u5408\u8fdb\u8109\u51b2\u795e\u7ecf\u7f51\u7edc\u4e2d<\/a><\/strong><\/span><\/section>\n
3. <\/strong><\/strong>Nature \u957f\u6587\u7efc\u8ff0\uff1a\u7c7b\u8111\u667a\u80fd\u4e0e\u8109\u51b2\u795e\u7ecf\u7f51\u7edc\u524d\u6cbf<\/a><\/strong><\/strong><\/span><\/section>\n
4. \u300a\u5f20\u6c5f\u00b7\u590d\u6742\u79d1\u5b66\u524d\u6cbf27\u8bb2\u300b\u5b8c\u6574\u4e0a\u7ebf\uff01<\/strong><\/a><\/strong><\/strong><\/strong><\/section>\n
5. \u6210\u4e3a\u96c6\u667aVIP\uff0c\u89e3\u9501\u5168\u7ad9\u8bfe\u7a0b\uff0f\u8bfb\u4e66\u4f1a<\/span><\/strong><\/a><\/strong><\/strong><\/strong><\/strong><\/section>\n
6. <\/strong><\/strong><\/strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/a><\/strong><\/strong><\/strong><\/span><\/section>\n


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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/span><\/strong><\/section>\n

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