{"id":42093,"date":"2023-04-25T18:43:00","date_gmt":"2023-04-25T10:43:00","guid":{"rendered":"https:\/\/swarma.org\/?p=42093"},"modified":"2023-04-25T18:43:00","modified_gmt":"2023-04-25T10:43:00","slug":"nat-commun-%e9%80%9f%e9%80%92%ef%bc%9a%e4%bd%9c%e4%b8%ba%e8%9b%8b%e7%99%bd%e8%b4%a8%e5%ba%8f%e5%88%97%e7%a9%ba%e9%97%b4%e5%8a%9f%e8%83%bd%e5%a4%9a%e6%a0%b7%e6%80%a7%e6%98%a0%e5%b0%84%e7%9a%84","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=42093","title":{"rendered":"Nat. Commun. \u901f\u9012\uff1a\u4f5c\u4e3a\u86cb\u767d\u8d28\u5e8f\u5217\u7a7a\u95f4\u529f\u80fd\u591a\u6837\u6027\u6620\u5c04\u7684\u6f5c\u5728\u751f\u6210\u666f\u89c2"},"content":{"rendered":"
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\u8bba\u6587\u9898\u76ee\uff1a<\/span>Latent generative landscapes as maps of functional diversity in protein sequence space<\/span><\/section>\n
\u8bba\u6587\u6765\u6e90\uff1aNature Communications<\/em><\/span><\/section>\n
\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41467-023-37958-z<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n

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\u53d8\u5206\u81ea\u52a8\u7f16\u7801\u5668\u662f\u5177\u6709\u751f\u6210\u80fd\u529b\u7684\u65e0\u76d1\u7763\u673a\u5668\u5b66\u4e60\u6a21\u578b\uff0c\u5f53\u5e94\u7528\u4e8e\u86cb\u767d\u8d28\u6570\u636e\u65f6\uff0c\u5b83\u4eec\u53ef\u4ee5\u901a\u8fc7\u7cfb\u7edf\u53d1\u80b2\u5bf9\u5e8f\u5217\u8fdb\u884c\u5206\u7c7b\uff0c\u5e76\u751f\u6210\u4fdd\u7559\u86cb\u767d\u8d28\u7ec4\u6210\u7edf\u8ba1\u7279\u6027\u7684\u65b0\u5e8f\u5217\u3002<\/span><\/section>\n

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\u4ee5\u524d\u7684\u7814\u7a76\u96c6\u4e2d\u5728\u805a\u7c7b\u548c\u751f\u6210\u7279\u5f81\u4e0a\uff0c\u6700\u65b0\u53d1\u8868\u4e8e Nature Communications \u7684\u8fd9\u9879\u7814\u7a76\uff0c\u8bc4\u4f30\u7684\u662f\u5e8f\u5217\u4fe1\u606f\u6240\u5d4c\u5165\u7684\u6f5c\u5728\u6d41\u5f62<\/span>\uff08underlying latent manifold\uff09<\/span>\u3002\u4e3a\u4e86\u7814\u7a76\u6f5c\u5728\u6d41\u5f62\u7684\u7279\u6027\uff0c\u4f5c\u8005\u5229\u7528\u76f4\u63a5\u8026\u5408\u5206\u6790\u548c Potts Hamiltonian \u6a21\u578b\u6765\u6784\u5efa\u4e00\u4e2a\u6f5c\u5728\u7684\u751f\u6210\u666f\u89c2\u3002\u8bba\u6587\u5c55\u793a\u4e86\u8fd9\u4e00\u666f\u89c2\u662f\u5982\u4f55\u6355\u6349\u7cfb\u7edf\u53d1\u80b2\u5206\u7ec4\uff0c\u4ee5\u53ca\u5305\u62ec Globins\u3001\u03b2-\u5185\u9170\u80fa\u9176\u3001\u79bb\u5b50\u901a\u9053\u548c\u8f6c\u5f55\u56e0\u5b50\u5728\u5185\u7684\u51e0\u4e2a\u7cfb\u7edf\u7684\u529f\u80fd\u548c\u9002\u5e94\u7279\u6027\u7684\u3002\u8fd9\u9879\u7814\u7a76\u8bf4\u660e\u666f\u89c2\u5982\u4f55\u5e2e\u52a9\u6211\u4eec\u7406\u89e3\u5b9e\u9a8c\u6570\u636e\u4e2d\u89c2\u5bdf\u5230\u7684\u5e8f\u5217\u53d8\u5f02\u6027\u7684\u5f71\u54cd\uff0c\u5e76\u63d0\u4f9b\u5173\u4e8e\u5b9a\u5411\u548c\u81ea\u7136\u86cb\u767d\u8d28\u6f14\u5316\u7684\u6d1e\u5bdf\u529b\u3002\u5c06\u53d8\u5206\u81ea\u52a8\u7f16\u7801\u5668\u7684\u751f\u6210\u7279\u6027\u548c\u529f\u80fd\u9884\u6d4b\u80fd\u529b\u4e0e\u534f\u540c\u6f14\u5316\u5206\u6790\u7ed3\u5408\u8d77\u6765\uff0c\u53ef\u80fd\u6709\u5229\u4e8e\u86cb\u767d\u8d28\u5de5\u7a0b\u548c\u8bbe\u8ba1\u7684\u5e94\u7528\u3002<\/span><\/section>\n

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\u6587\u7ae0\u6307\u51fa\uff0c\u86cb\u767d\u8d28\u5e8f\u5217\u7a7a\u95f4\u4e2d\u5b58\u5728\u7740\u8bb8\u591a\u4e0d\u540c\u7684\u529f\u80fd\uff0c\u4f46\u662f\u8fd9\u4e9b\u529f\u80fd\u4e4b\u95f4\u7684\u5173\u7cfb\u5f88\u96be\u88ab\u76f4\u63a5\u89c2\u5bdf\u5230\u3002\u4f5c\u8005\u4eec\u4f7f\u7528\u4e86\u4e00\u79cd\u65b0\u7684\u65b9\u6cd5\u6765\u7814\u7a76\u8fd9\u4e9b\u529f\u80fd\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u8fd9\u79cd\u65b9\u6cd5\u88ab\u79f0\u4e3a\u201c\u6f5c\u5728\u751f\u6210\u666f\u89c2\u201d\u3002\u6f5c\u5728\u751f\u6210\u666f\u89c2\u53ef\u4ee5\u7528\u6765\u63cf\u8ff0\u86cb\u767d\u8d28\u5e8f\u5217\u7a7a\u95f4\u4e2d\u7684\u529f\u80fd\u591a\u6837\u6027\uff0c\u5e76\u4e14\u53ef\u4ee5\u7528\u6765\u9884\u6d4b\u65b0\u7684\u86cb\u767d\u8d28\u5e8f\u5217\u7684\u529f\u80fd\u3002<\/span><\/section>\n

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\u56fe1. \u6f5c\u5728\u751f\u6210\u666f\u89c2 (LGL) \u65b9\u6cd5\u6982\u8ff0\u3002<\/span><\/p>\n


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\u56fe2. \u71b5\u548c\u54c8\u5bc6\u987f\u5206\u6570\u4e0e tRNA \u5408\u6210\u9176\u5bb6\u65cf\u8bad\u7ec3\u5e8f\u5217\u4fdd\u771f\u5ea6\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/span><\/p>\n


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\u56fe3. \u5c40\u90e8\u751f\u6210\u666f\u89c2\u5728\u86cb\u767d\u8d28\u5de5\u7a0b\u4e2d\u7684\u5e94\u7528\u3002<\/span><\/p>\n


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AI+Science \u8bfb\u4e66\u4f1a\u542f\u52a8<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/span><\/section>\n
\u4eba\u5de5\u667a\u80fd\u548c\u79d1\u5b66\u53d1\u73b0\u76f8\u4e92\u8d4b\u80fd\u7684\u65b0\u8303\u5f0f\uff1aAI+Science \u8bfb\u4e66\u4f1a\u542f\u52a8<\/a><\/span><\/span><\/section>\n

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\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n

1. <\/strong>\u5df4\u62c9\u5df4\u897f\u65b0\u4f5c\uff1aAI-Bind \u52a9\u529b\u86cb\u767d\u8d28-\u914d\u4f53\u7ed3\u5408\u9884\u6d4b<\/a><\/strong><\/span><\/strong><\/strong><\/section>\n
2.<\/strong> Science\u524d\u6cbf\uff1a\u5927\u8bed\u8a00\u6a21\u578b\u6d8c\u73b0\u6f14\u5316\u4fe1\u606f\uff0c\u52a0\u901f\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b<\/a><\/strong><\/span><\/strong><\/section>\n
3. <\/strong><\/strong>Science \u901f\u9012\uff1a\u5927\u8bed\u8a00\u6a21\u578b\u5bf9\u86cb\u767d\u8d28\u7ed3\u6784\u8fdb\u884c\u6f14\u5316\u5c3a\u5ea6\u9884\u6d4b<\/a><\/strong><\/strong><\/span><\/strong><\/strong><\/section>\n
4. \u300a\u5f20\u6c5f\u00b7\u590d\u6742\u79d1\u5b66\u524d\u6cbf27\u8bb2\u300b\u5b8c\u6574\u4e0a\u7ebf\uff01<\/strong><\/a><\/strong><\/strong><\/strong><\/section>\n
5. \u6210\u4e3a\u96c6\u667aVIP\uff0c\u89e3\u9501\u5168\u7ad9\u8bfe\u7a0b\uff0f\u8bfb\u4e66\u4f1a<\/span><\/strong><\/a><\/strong><\/strong><\/strong><\/strong><\/section>\n
6.<\/strong><\/strong><\/strong> <\/strong><\/strong><\/strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/a><\/strong><\/strong><\/strong><\/span><\/section>\n

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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/strong><\/span><\/strong><\/section>\n

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\u5173\u952e\u8bcd\uff1a\u53d8\u5206\u81ea\u52a8\u7f16\u7801\u5668\uff0c\u751f\u6210\u6a21\u578b\uff0c\u751f\u6210\u666f\u89c2\uff0c\u86cb\u767d\u8d28\u9884\u6d4b \u8bba\u6587\u9898\u76ee\uff1aLatent generative landscapes as maps of functional diversity in protein sequence space \u8bba\u6587\u6765\u6e90\uff1aNature Communications \u8bba\u6587\u94fe…<\/p>\n","protected":false},"author":0,"featured_media":42087,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/42093"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=42093"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/42093\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/42087"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=42093"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=42093"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=42093"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=42093"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}