{"id":43401,"date":"2023-06-30T19:23:54","date_gmt":"2023-06-30T11:23:54","guid":{"rendered":"https:\/\/swarma.org\/?p=43401"},"modified":"2023-06-30T19:23:54","modified_gmt":"2023-06-30T11:23:54","slug":"%e7%94%9f%e7%89%a9%e5%8c%bb%e8%8d%af%e7%9f%a5%e8%af%86%e5%9b%be%e8%b0%b1%e5%ad%a6%e4%b9%a0%e6%96%b0%e6%a1%86%e6%9e%b6-nat-commun-%e9%80%9f%e9%80%92","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=43401","title":{"rendered":"\u751f\u7269\u533b\u836f\u77e5\u8bc6\u56fe\u8c31\u5b66\u4e60\u65b0\u6846\u67b6 | Nat. Commun. \u901f\u9012"},"content":{"rendered":"
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\u8bba\u6587\u9898\u76ee\uff1aBiomedical knowledge graph learning for drug repurposing by extending guilt-by-association to multiple layers<\/span><\/section>\n
\u8bba\u6587\u6765\u6e90\uff1aNature Communications<\/em><\/span><\/section>\n
\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/pattern.swarma.org\/paper\/30c7d654-0bd2-11ee-a270-0242ac17000d<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n

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\u8ba1\u7b97\u836f\u7269\u518d\u5229\u7528<\/span>\uff08Computational drug repurposing\uff09<\/span>\u65e8\u5728\u901a\u8fc7\u5229\u7528\u9ad8\u901a\u91cf\u6570\u636e<\/span>\uff08\u901a\u5e38\u4ee5\u751f\u7269\u533b\u5b66\u77e5\u8bc6\u56fe\u8c31\u7684\u5f62\u5f0f\uff09<\/span>\uff0c\u5229\u7528\u5df2\u6709\u836f\u7269\u6cbb\u7597\u65b0\u7684\u75c5\u75c7\u3002\u7136\u800c\uff0c\u7531\u4e8e\u57fa\u56e0\u8282\u70b9\u6570\u91cf\u5de8\u5927\u800c\u836f\u7269\u3001\u75be\u75c5\u8282\u70b9\u6570\u91cf\u5f88\u5c11\uff0c\u5bfc\u81f4\u8868\u793a\u4e0d\u592a\u6709\u6548\uff0c\u751f\u7269\u533b\u5b66\u77e5\u8bc6\u56fe\u8c31\u4e0a\u7684\u5b66\u4e60\u5f88\u6709\u6311\u6218\u6027\u3002<\/span><\/section>\n

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\u4e3a\u4e86\u514b\u670d\u8fd9\u4e00\u6311\u6218\uff0c\u8fd9\u7bc7\u6587\u7ae0\u63d0\u51fa\u4e00\u79cd\u201c\u8bed\u4e49\u591a\u5c42\u5173\u8054\u201d<\/span>\uff08semantic multi-layer guilt-by-association\uff09<\/span>\u65b9\u6cd5\uff0c\u5229\u7528\u4e86\u836f\u7269-\u57fa\u56e0-\u75be\u75c5\u6c34\u5e73\u7684\u5173\u8054\u539f\u5219\u2014\u2014\u201c\u76f8\u4f3c\u7684\u57fa\u56e0\u5171\u4eab\u76f8\u4f3c\u7684\u529f\u80fd\u201d\u3002\u4f7f\u7528\u8fd9\u79cd\u65b9\u6cd5\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u6a21\u578b DREAMwalk: Drug Repurposing through Exploring Associations Using Multi-layer random walk\uff0c\u901a\u8fc7\u4f7f\u7528\u4ed6\u4eec\u7684\u8bed\u4e49\u4fe1\u606f\u5f15\u5bfc\u7684\u968f\u673a\u6e38\u8d70\u6765\u751f\u6210\u5927\u91cf\u836f\u7269\u548c\u75be\u75c5\u7684\u8282\u70b9\u5e8f\u5217\uff0c\u5141\u8bb8\u5728\u7edf\u4e00\u7684\u5d4c\u5165\u7a7a\u95f4\u4e2d\u6709\u6548\u5730\u6620\u5c04\u836f\u7269\u548c\u75be\u75c5\u3002<\/span><\/section>\n

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\u56fe1\uff1aDREAMwalk \u6846\u67b6\u6982\u89c8\u3002<\/span><\/section>\n

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\u56fe3\uff1aDREAMwalk \u7684\u5d4c\u5165\u7a7a\u95f4\u53cd\u6620\u4e86\u836f\u7269\u7684\u836f\u7406\u5b66\u548c\u751f\u7269\u5b66\u7cfb\u7edf\u7ea7\u7279\u5f81\u3002<\/span><\/section>\n

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\u200d<\/span>1. <\/strong>Nat. Mach. Intell. \u901f\u9012\uff1a\u57fa\u4e8e\u529f\u80fd\u63d0\u793a\u7684\u77e5\u8bc6\u56fe\u8c31\u53d1\u73b0\u65b0\u836f\u7269<\/a><\/strong><\/span><\/strong><\/section>\n
2.<\/strong> \u77e5\u8bc6\u5c31\u662fAI\u7684\u529b\u91cf\uff1a\u4ece\u77e5\u8bc6\u5de5\u7a0b\u5230\u77e5\u8bc6\u56fe\u8c31\u5168\u9762\u56de\u987e<\/a><\/strong><\/span><\/section>\n
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3. <\/strong><\/strong>\u8ba4\u77e5\u6df1\u5ea6\u5b66\u4e60\uff1a\u4ece\u6784\u5efa\u77e5\u8bc6\u56fe\u8c31\u5230\u6d8c\u73b0\u8ba4\u77e5\u667a\u80fd<\/a><\/strong><\/strong><\/span><\/section>\n
4. \u300a\u5f20\u6c5f\u00b7\u590d\u6742\u79d1\u5b66\u524d\u6cbf27\u8bb2\u300b\u5b8c\u6574\u4e0a\u7ebf\uff01<\/strong><\/a><\/strong><\/strong><\/strong><\/section>\n
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5. \u6210\u4e3a\u96c6\u667aVIP\uff0c\u89e3\u9501\u5168\u7ad9\u8bfe\u7a0b\uff0f\u8bfb\u4e66\u4f1a<\/span><\/strong><\/a><\/strong><\/strong><\/strong><\/strong><\/section>\n
6.<\/strong><\/strong><\/strong> <\/strong><\/strong><\/strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/a><\/strong><\/strong><\/strong><\/span><\/section>\n

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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/strong><\/span><\/strong><\/section>\n

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\u5173\u952e\u8bcd\uff1a\u77e5\u8bc6\u56fe\u8c31\uff0c\u5d4c\u5165\u7a7a\u95f4\uff0c\u94fe\u8def\u9884\u6d4b\uff0c\u968f\u673a\u6e38\u8d70\uff0c\u8bed\u4e49\u591a\u5c42\u5173\u8054 \u8bba\u6587\u9898\u76ee\uff1aBiomedical knowledge graph learning for drug repurposing by extending guilt-by-association to multiple layers \u8bba\u6587\u6765\u6e90…<\/p>\n","protected":false},"author":0,"featured_media":43393,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/43401"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43401"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/43401\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/43393"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43401"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43401"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43401"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=43401"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}