{"id":44339,"date":"2023-08-04T08:02:34","date_gmt":"2023-08-04T00:02:34","guid":{"rendered":"https:\/\/swarma.org\/?p=44339"},"modified":"2023-08-04T08:02:34","modified_gmt":"2023-08-04T00:02:34","slug":"%e5%a4%a7%e5%9e%8b%e8%af%ad%e8%a8%80%e6%a8%a1%e5%9e%8b%e7%9a%84%e4%b8%8b%e4%b8%80%e4%b8%aa%e5%89%8d%e6%b2%bf%e6%98%af%e7%94%9f%e7%89%a9%e5%ad%a6","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=44339","title":{"rendered":"\u5927\u578b\u8bed\u8a00\u6a21\u578b\u7684\u4e0b\u4e00\u4e2a\u524d\u6cbf\u662f\u751f\u7269\u5b66"},"content":{"rendered":"<div class='wxsyncmain'>\n<section powered-by=\"xiumi.us\" data-mpa-powered-by=\"yiban.io\">\n<section>\n<section>\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(63, 63, 63);font-family: PingFangSC-light;font-size: 15px;background-color: rgb(255, 255, 255);visibility: visible;\">\n<section style=\"outline: 0px;display: inline-block;width: 661px;vertical-align: top;background-color: rgb(246, 246, 246);visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;\">\n<p style=\"text-align: center;\"><img class=\"rich_pages wxw-img\" data-backh=\"379\" data-backw=\"578\" data-ratio=\"0.6548488008342023\" data-type=\"jpeg\" data-w=\"959\" style=\"letter-spacing: 0.578px;white-space: normal;width: 100%;height: auto !important;\"  src=\"\/wp-content\/uploads\/2023\/08\/wxsync-2023-08-fcf0cf4a771771bbd6d5aa48df42657c.jpeg\"  \/><\/p>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;outline: 0px;letter-spacing: 0.544px;visibility: visible;\">\n<section style=\"outline: 0px;width: 661px;visibility: visible;\">\n<section style=\"padding-right: 3px;outline: 0px;float: left;line-height: 1;visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;text-align: left;visibility: visible;\">\n<section style=\"padding-left: 10px;outline: 0px;display: inline-block;width: 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0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.578px;text-indent: 0em;font-size: 15px;visibility: visible;\"><\/strong><\/section>\n<section style=\"padding-right: 8px;padding-left: 8px;outline: 0px;font-size: 13px;line-height: 2;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.578px;text-indent: 0em;font-size: 15px;visibility: visible;\"><span style=\"outline: 0px;font-size: 13px;letter-spacing: 0.544px;text-decoration-style: solid;text-decoration-color: rgb(63, 63, 63);visibility: visible;\"><br style=\"outline: 0px;visibility: visible;\"  \/><\/span><\/strong><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;outline: 0px;visibility: visible;\"><strong style=\"outline: 0px;font-size: 13px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><span style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><span style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><span style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><span style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><span style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><span style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;color: rgb(0, 0, 0);text-align: start;visibility: visible;\">\u7814\u7a76\u9886\u57df\uff1a\u5927\u578b\u8bed\u8a00\u6a21\u578b\uff0c\u4eba\u5de5\u667a\u80fd\uff0cAI for Science\uff0c\u86cb\u767d\u8d28\u8bbe\u8ba1\uff0c\u751f\u7269\u5b66\u57fa\u7840\u6a21\u578b<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/section>\n<section style=\"padding-right: 8px;padding-left: 8px;outline: 0px;font-size: 13px;line-height: 2;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.578px;text-indent: 0em;font-size: 15px;visibility: visible;\"><\/strong><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 5px;margin-bottom: 5px;outline: 0px;visibility: visible;\">\n<section style=\"padding-right: 8px;padding-left: 8px;outline: 0px;font-size: 13px;line-height: 2;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.578px;text-indent: 0em;font-size: 15px;visibility: visible;\"><\/strong><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 5px;margin-bottom: 5px;outline: 0px;visibility: visible;\">\n<section style=\"padding-right: 8px;padding-left: 8px;outline: 0px;font-size: 13px;line-height: 2;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\"><strong style=\"outline: 0px;visibility: visible;\"><\/strong><\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;width: 661px;visibility: visible;\">\n<section style=\"outline: 0px;clear: both;line-height: 0;visibility: visible;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;visibility: visible;\"><svg viewbox=\"0 0 1 1\" 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0px;letter-spacing: 0.544px;white-space: normal;color: rgb(63, 63, 63);font-family: PingFangSC-light;font-size: 15px;background-color: rgb(255, 255, 255);text-align: right;visibility: visible;\">\n<section style=\"outline: 0px;vertical-align: middle;display: inline-block;line-height: 0;visibility: visible;\"><span style=\"font-family: PingFangSC-light;text-align: right;outline: 0px;visibility: visible;color: rgb(73, 73, 73);background-color: rgb(255, 255, 255);font-size: 13px;letter-spacing: 0.544px;text-decoration: none solid rgb(73, 73, 73);\">Rob Toews<\/span><span style=\"outline: 0px;color: rgb(73, 73, 73);font-family: PingFangSC-light;letter-spacing: 0.544px;text-align: right;background-color: rgb(255, 255, 255);font-size: 16px;visibility: visible;\">&nbsp;<\/span><span style=\"outline: 0px;color: rgb(73, 73, 73);font-family: PingFangSC-light;letter-spacing: 0.544px;text-align: right;background-color: rgb(255, 255, 255);font-size: 13px;visibility: visible;\"><strong style=\"outline: 0px;color: rgb(0, 0, 0);visibility: visible;\">| \u4f5c\u8005<\/strong><\/span><\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(63, 63, 63);font-family: PingFangSC-light;font-size: 15px;background-color: rgb(255, 255, 255);text-align: right;visibility: visible;\">\n<section style=\"outline: 0px;vertical-align: middle;display: inline-block;line-height: 0;visibility: visible;\"><br  \/><\/section>\n<section style=\"outline: 0px;vertical-align: middle;display: inline-block;line-height: 0;visibility: visible;\">\n<section style=\"outline: 0px;vertical-align: middle;display: inline-block;line-height: 0;visibility: visible;\"><span style=\"font-family: PingFangSC-light;text-align: right;outline: 0px;visibility: visible;color: rgb(73, 73, 73);background-color: rgb(255, 255, 255);font-size: 13px;letter-spacing: 0.544px;text-decoration: none solid rgb(73, 73, 73);\">\u79d1\u6280\u4e16\u4ee3\u5343\u9ad8\u539f<\/span><\/section>\n<\/section>\n<section style=\"outline: 0px;vertical-align: middle;display: inline-block;line-height: 0;visibility: visible;\">\n<section style=\"outline: 0px;vertical-align: middle;display: inline-block;line-height: 0;visibility: visible;\">\n<section style=\"outline: 0px;vertical-align: middle;display: inline-block;line-height: 0;visibility: visible;\"><span style=\"outline: 0px;color: rgb(73, 73, 73);font-family: PingFangSC-light;letter-spacing: 0.544px;text-align: right;background-color: rgb(255, 255, 255);font-size: 13px;visibility: visible;\"><strong style=\"outline: 0px;color: rgb(0, 0, 0);visibility: visible;\">&nbsp;| \u6765\u6e90<\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<section style=\"outline: 0px;vertical-align: middle;display: inline-block;line-height: 0;visibility: visible;\">\n<section style=\"outline: 0px;vertical-align: middle;display: inline-block;line-height: 0;visibility: visible;\"><br  \/><\/section>\n<\/section>\n<section style=\"outline: 0px;vertical-align: middle;display: inline-block;line-height: 0;visibility: visible;\"><br  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;letter-spacing: 0.578px;white-space: normal;line-height: 1.75em;\"><br  \/><\/section>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u50cf GPT-4 \u8fd9\u6837\u7684\u5927\u578b\u8bed\u8a00\u6a21\u578b\u56e0\u5176\u5bf9\u81ea\u7136\u8bed\u8a00\u7684\u60ca\u4eba\u638c\u63e1\u800c\u5e2d\u5377\u4e86\u4e16\u754c\u3002\u7136\u800c\uff0c\u5927\u8bed\u8a00\u6a21\u578b\u6700\u91cd\u8981\u7684\u957f\u671f\u673a\u4f1a\u5c06\u9700\u8981\u4e00\u79cd\u5b8c\u5168\u4e0d\u540c\u7c7b\u578b\u7684\u8bed\u8a00\uff1a\u751f\u7269\u5b66\u8bed\u8a00\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u8fc7\u53bb\u4e00\u4e2a\u4e16\u7eaa\uff0c\u751f\u7269\u5316\u5b66\u3001\u5206\u5b50\u751f\u7269\u5b66\u548c\u9057\u4f20\u5b66\u7814\u7a76\u8fdb\u5c55\u7684\u957f\u5f81\u4e2d\u51fa\u73b0\u4e86\u4e00\u4e2a\u5f15\u4eba\u6ce8\u76ee\u7684\u4e3b\u9898\uff1a\u4e8b\u5b9e\u8bc1\u660e\uff0c\u751f\u7269\u5b66\u662f\u4e00\u4e2a\u53ef\u7834\u8bd1\u3001\u53ef\u7f16\u7a0b\u3001\u5728\u67d0\u4e9b\u65b9\u9762\u751a\u81f3\u662f\u6570\u5b57\u7cfb\u7edf\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">DNA \u4ec5\u4f7f\u7528\u56db\u4e2a\u53d8\u91cf\u2014\u2014A<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u817a\u560c\u5464\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u3001C<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u80de\u5627\u5576\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u3001G<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u9e1f\u560c\u5464\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u548c T<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u80f8\u817a\u5627\u5576\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u6765\u7f16\u7801\u5730\u7403\u4e0a\u6bcf\u4e2a\u751f\u7269\u4f53\u7684\u5b8c\u6574\u9057\u4f20\u6307\u4ee4\u3002\u5c06\u6b64\u4e0e\u73b0\u4ee3\u8ba1\u7b97\u7cfb\u7edf\u8fdb\u884c\u6bd4\u8f83\uff0c\u73b0\u4ee3\u8ba1\u7b97\u7cfb\u7edf\u4f7f\u7528\u4e24\u4e2a\u53d8\u91cf<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff080 \u548c 1\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 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63);\">\u518d\u4e3e\u4e00\u4e2a\u4f8b\u5b50\uff0c\u6bcf\u4e2a\u751f\u7269\u4f53\u4e2d\u7684\u6bcf\u79cd\u86cb\u767d\u8d28\u90fd\u7531\u4ee5\u7279\u5b9a\u987a\u5e8f\u8fde\u63a5\u5728\u4e00\u8d77\u7684\u4e00\u7ef4\u6c28\u57fa\u9178\u4e32\u7ec4\u6210\u5e76\u5b9a\u4e49\u3002\u86cb\u767d\u8d28\u7684\u957f\u5ea6\u4ece\u51e0\u5341\u5230\u51e0\u5343\u4e2a\u6c28\u57fa\u9178\u4e0d\u7b49\uff0c\u6709 20 \u79cd\u4e0d\u540c\u7684\u6c28\u57fa\u9178\u53ef\u4f9b\u9009\u62e9\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u8fd9\u4e5f\u4ee3\u8868\u4e86\u4e00\u79cd\u975e\u5e38\u53ef\u8ba1\u7b97\u7684\u7cfb\u7edf\uff0c\u8bed\u8a00\u6a21\u578b\u975e\u5e38\u9002\u5408\u5b66\u4e60\u8be5\u7cfb\u7edf\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u6b63\u5982 DeepMind \u9996\u5e2d\u6267\u884c\u5b98\u517c\u8054\u5408\u521b\u59cb\u4ebaDemis Hassabis \u6240\u8bf4\uff1a\u201c\u5728\u6700\u57fa\u672c\u7684\u5c42\u9762\u4e0a\uff0c\u6211\u8ba4\u4e3a\u751f\u7269\u5b66\u53ef\u4ee5\u88ab\u89c6\u4e3a\u4e00\u79cd\u4fe1\u606f\u5904\u7406\u7cfb\u7edf\uff0c\u5c3d\u7ba1\u5b83\u662f\u4e00\u4e2a\u6781\u5176\u590d\u6742\u548c\u52a8\u6001\u7684\u7cfb\u7edf\u3002\u6b63\u5982\u6570\u5b66\u88ab\u8bc1\u660e\u662f\u7269\u7406\u5b66\u7684\u6b63\u786e\u63cf\u8ff0\u8bed\u8a00\u4e00\u6837\uff0c\u751f\u7269\u5b66\u4e5f\u53ef\u80fd\u6210\u4e3a\u4eba\u5de5\u667a\u80fd\u5e94\u7528\u7684\u5b8c\u7f8e\u7c7b\u578b\u3002\u201d<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5f53\u5927\u578b\u8bed\u8a00\u6a21\u578b\u80fd\u591f\u5229\u7528\u5927\u91cf\u4fe1\u53f7\u4e30\u5bcc\u7684\u6570\u636e\uff0c\u63a8\u65ad\u51fa\u8fdc\u8fdc\u8d85\u51fa\u4efb\u4f55\u4eba\u7c7b\u5438\u6536\u80fd\u529b\u7684\u6f5c\u5728\u6a21\u5f0f\u548c\u6df1\u5c42\u7ed3\u6784\u65f6\uff0c\u5b83\u4eec\u5c31\u4f1a\u53d8\u5f97\u6700\u5f3a\u5927\u3002\u7136\u540e\uff0c\u4ed6\u4eec\u53ef\u4ee5\u5229\u7528\u5bf9\u4e3b\u9898\u7684\u590d\u6742\u7406\u89e3\u6765\u751f\u6210\u65b0\u9896\u3001\u4ee4\u4eba\u60ca\u53f9\u7684\u590d\u6742\u8f93\u51fa\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;color: rgb(63, 63, 63);font-size: 15px;letter-spacing: 0.034em;\">\u4f8b\u5982\uff0c\u901a\u8fc7\u5438\u6536\u4e92\u8054\u7f51\u4e0a\u7684\u6240\u6709\u6587\u672c\uff0cChatGPT \u7b49\u5de5\u5177\u5df2\u7ecf\u5b66\u4f1a\u4e86\u5c31\u4efb\u4f55\u53ef\u4ee5\u60f3\u8c61\u7684\u8bdd\u9898\u8fdb\u884c\u6df1\u601d\u719f\u8651\u548c\u7ec6\u81f4\u5165\u5fae\u7684\u4ea4\u8c08\u3002\u901a\u8fc7\u6444\u53d6\u6570\u5341\u4ebf\u5f20\u56fe\u50cf\uff0c Midjourney\u7b49\u6587\u672c\u5230\u56fe\u50cf\u6a21\u578b\u5df2\u7ecf\u5b66\u4f1a\u4e86\u6309\u9700\u751f\u6210\u521b\u610f\u539f\u521b\u56fe\u50cf\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5c06\u5927\u578b\u8bed\u8a00\u6a21\u578b\u6307\u5411\u751f\u7269\u6570\u636e\u2014\u2014\u4f7f\u5b83\u4eec\u80fd\u591f\u5b66\u4e60\u751f\u547d\u7684\u8bed\u8a00\u2014\u2014\u5c06\u91ca\u653e\u5404\u79cd\u53ef\u80fd\u6027\uff0c\u4f7f\u81ea\u7136\u8bed\u8a00\u548c\u56fe\u50cf\u76f8\u6bd4\u4e4b\u4e0b\u663e\u5f97\u5fae\u4e0d\u8db3\u9053\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5177\u4f53\u6765\u8bf4\uff0c\u8fd9\u4f1a\u662f\u4ec0\u4e48\u6837\u5b50\uff1f<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u77ed\u671f\u5185\uff0c\u5728\u751f\u547d\u79d1\u5b66\u4e2d\u5e94\u7528\u5927\u578b\u8bed\u8a00\u6a21\u578b\u7684\u6700\u5f15\u4eba\u6ce8\u76ee\u7684\u673a\u4f1a\u662f\u8bbe\u8ba1\u65b0\u578b\u86cb\u767d\u8d28\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/p>\n<h3 style=\"outline: 0px;white-space: normal;letter-spacing: 0.544px;font-family: -apple-system, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;font-family: PingFangSC-light;text-align: right;font-size: 13px;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;letter-spacing: 0.544px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;\">\n<section style=\"outline: 0px;display: inline-block;vertical-align: middle;\">\n<section style=\"margin-bottom: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;clear: both;line-height: 0;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;border-left: 3px solid rgb(33, 166, 210);border-right: 3px solid rgb(33, 166, 210);border-top-color: rgb(33, 166, 210);border-bottom-color: rgb(33, 166, 210);font-size: 16px;color: rgb(0, 0, 0);line-height: 1.4;\">\n<p style=\"outline: 0px;\"><span style=\"outline: 0px;font-size: 17px;\"><strong style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\">\u86cb\u767d\u8d28101<\/strong><\/strong><\/span><\/p>\n<\/section>\n<section style=\"margin-top: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;font-size: 16px;white-space: normal;line-height: 1.75em;\"><br style=\"outline: 0px;font-family: system-ui, -apple-system, &quot;system-ui&quot;, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u86cb\u767d\u8d28\u662f\u751f\u547d\u672c\u8eab\u7684\u4e2d\u5fc3\u3002\u6b63\u5982\u8457\u540d\u751f\u7269\u5b66\u5bb6\u963f\u745f\u00b7\u83b1\u65af\u514b<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\"> (Arthur Lesk) <\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u8bf4\u9053\uff1a\u201c\u5728\u5206\u5b50\u5c3a\u5ea6\u7684\u751f\u547d\u620f\u5267\u4e2d\uff0c\u86cb\u767d\u8d28\u662f\u53d1\u6325\u4f5c\u7528\u7684\u5730\u65b9\u3002\u201d<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u86cb\u767d\u8d28\u51e0\u4e4e\u53c2\u4e0e\u6240\u6709\u751f\u7269\u4f53\u5185\u53d1\u751f\u7684\u6bcf\u9879\u91cd\u8981\u6d3b\u52a8\uff1a\u6d88\u5316\u98df\u7269\u3001\u6536\u7f29\u808c\u8089\u3001\u5728\u5168\u8eab\u8f93\u9001\u6c27\u6c14\u3001\u653b\u51fb\u5916\u6765\u75c5\u6bd2\u3002\u4f60\u7684\u8377\u5c14\u8499\u662f\u7531\u86cb\u767d\u8d28\u7ec4\u6210\u7684\uff1b\u4f60\u7684\u5934\u53d1\u4e5f\u662f\u5982\u6b64\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u86cb\u767d\u8d28\u975e\u5e38\u91cd\u8981\uff0c\u56e0\u4e3a\u5b83\u4eec\u7528\u9014\u5e7f\u6cdb\u3002\u5b83\u4eec\u80fd\u591f\u627f\u62c5\u5927\u91cf\u4e0d\u540c\u7684\u7ed3\u6784\u548c\u529f\u80fd\uff0c\u8fdc\u8fdc\u8d85\u8fc7\u4efb\u4f55\u5176\u4ed6\u7c7b\u578b\u7684\u751f\u7269\u5206\u5b50\u3002\u8fd9\u79cd\u4ee4\u4eba\u96be\u4ee5\u7f6e\u4fe1\u7684\u591a\u529f\u80fd\u6027\u662f\u86cb\u767d\u8d28\u6784\u5efa\u65b9\u5f0f\u7684\u76f4\u63a5\u7ed3\u679c\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5982\u4e0a\u6240\u8ff0\uff0c\u6bcf\u79cd\u86cb\u767d\u8d28\u90fd\u7531\u4e00\u4e32\u6309\u7279\u5b9a\u987a\u5e8f\u4e32\u5728\u4e00\u8d77\u7684\u79f0\u4e3a\u6c28\u57fa\u9178\u7684\u7ed3\u6784\u5355\u5143\u7ec4\u6210\u3002\u57fa\u4e8e\u8fd9\u79cd\u4e00\u7ef4\u6c28\u57fa\u9178\u5e8f\u5217\uff0c\u86cb\u767d\u8d28\u6298\u53e0\u6210\u590d\u6742\u7684\u4e09\u7ef4\u5f62\u72b6\uff0c\u4f7f\u5b83\u4eec\u80fd\u591f\u53d1\u6325\u5176\u751f\u7269\u529f\u80fd\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u86cb\u767d\u8d28\u7684\u5f62\u72b6\u4e0e\u5176\u529f\u80fd\u5bc6\u5207\u76f8\u5173\u3002\u4e3e\u4e2a\u4f8b\u5b50\uff0c\u6297\u4f53\u86cb\u767d\u6298\u53e0\u6210\u5f62\u72b6\uff0c\u4f7f\u5b83\u4eec\u80fd\u591f\u7cbe\u786e\u8bc6\u522b\u548c\u7784\u51c6\u5f02\u7269\uff0c\u5c31\u50cf\u94a5\u5319\u63d2\u5165\u9501\u4e2d\u4e00\u6837\u3002\u53e6\u4e00\u4e2a\u4f8b\u5b50\uff0c\u9176\u2014\u2014\u52a0\u901f\u751f\u5316\u53cd\u5e94\u7684\u86cb\u767d\u8d28\u2014\u2014\u7ecf\u8fc7\u4e13\u95e8\u8bbe\u8ba1\uff0c\u53ef\u4ee5\u4e0e\u7279\u5b9a\u5206\u5b50\u7ed3\u5408\uff0c\u4ece\u800c\u50ac\u5316\u7279\u5b9a\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u4e86\u89e3\u86cb\u767d\u8d28\u6298\u53e0\u6210\u7684\u5f62\u72b6\u5bf9\u4e8e\u4e86\u89e3\u751f\u7269\u4f53\u5982\u4f55\u8fd0\u4f5c\u4ee5\u53ca\u6700\u7ec8\u4e86\u89e3\u751f\u547d\u672c\u8eab\u5982\u4f55\u8fd0\u4f5c\u81f3\u5173\u91cd\u8981\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u534a\u4e2a\u591a\u4e16\u7eaa\u4ee5\u6765\uff0c\u4ec5\u6839\u636e\u86cb\u767d\u8d28\u7684\u4e00\u7ef4\u6c28\u57fa\u9178\u5e8f\u5217\u786e\u5b9a\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\u7ed3\u6784\u4e00\u76f4\u662f\u751f\u7269\u5b66\u9886\u57df\u7684\u4e00\u9879\u5de8\u5927\u6311\u6218\u3002\u5b83\u88ab\u79f0\u4e3a\u201c\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u201d\uff0c\u56f0\u6270\u4e86\u51e0\u4ee3\u79d1\u5b66\u5bb6\u30022007 \u5e74\uff0c\u4e00\u4f4d\u8bc4\u8bba\u5458\u5c06\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u63cf\u8ff0\u4e3a\u201c\u73b0\u4ee3\u79d1\u5b66\u4e2d\u6700\u91cd\u8981\u4f46\u5c1a\u672a\u89e3\u51b3\u7684\u95ee\u9898\u4e4b\u4e00\u201d\u3002<br  \/>&nbsp;<\/p>\n<p><\/span><\/p>\n<h3 style=\"outline: 0px;white-space: normal;letter-spacing: 0.544px;font-family: -apple-system, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;font-family: PingFangSC-light;text-align: right;font-size: 13px;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;letter-spacing: 0.544px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;\">\n<section style=\"outline: 0px;display: inline-block;vertical-align: middle;\">\n<section style=\"margin-bottom: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;clear: both;line-height: 0;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;border-left: 3px solid rgb(33, 166, 210);border-right: 3px solid rgb(33, 166, 210);border-top-color: rgb(33, 166, 210);border-bottom-color: rgb(33, 166, 210);font-size: 16px;color: rgb(0, 0, 0);line-height: 1.4;\">\n<p style=\"outline: 0px;\"><span style=\"outline: 0px;font-size: 17px;\"><strong style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\">\u6df1\u5ea6\u5b66\u4e60\u548c\u86cb\u767d\u8d28\uff1a\u5929\u4f5c\u4e4b\u5408<\/strong><\/strong><\/span><\/p>\n<\/section>\n<section style=\"margin-top: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;font-size: 16px;white-space: normal;line-height: 1.75em;\"><br style=\"outline: 0px;font-family: system-ui, -apple-system, &quot;system-ui&quot;, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">2020 \u5e74\u5e95\uff0c\u5728\u751f\u7269\u5b66\u548c\u8ba1\u7b97\u9886\u57df\u7684\u5206\u6c34\u5cad\u65f6\u523b\uff0c\u4e00\u4e2a\u540d\u4e3aAlphaFold\u7684\u4eba\u5de5\u667a\u80fd\u7cfb\u7edf\u63d0\u51fa\u4e86\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u7684\u89e3\u51b3\u65b9\u6848\u3002AlphaFold\u7531 Alphabet \u7684 DeepMind \u6784\u5efa\uff0c\u80fd\u591f\u5728\u5927\u7ea6\u4e00\u4e2a\u539f\u5b50\u7684\u5bbd\u5ea6\u5185\u6b63\u786e\u9884\u6d4b\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\u5f62\u72b6\uff0c\u8fdc\u8fdc\u4f18\u4e8e\u4eba\u7c7b\u66fe\u7ecf\u8bbe\u8ba1\u8fc7\u7684\u4efb\u4f55\u5176\u4ed6\u65b9\u6cd5\u3002<br  \/>&nbsp;<br  \/>AlphaFold \u7684\u91cd\u8981\u6027\u600e\u4e48\u5f3a\u8c03\u90fd\u4e0d\u4e3a\u8fc7\u3002\u957f\u671f\u86cb\u767d\u8d28\u6298\u53e0\u4e13\u5bb6\u7ea6\u7ff0\u00b7\u83ab\u5c14\u7279 \u603b\u7ed3\u5f97\u5f88\u597d\uff1a\u201c\u8fd9\u662f\u4eba\u5de5\u667a\u80fd\u7b2c\u4e00\u6b21\u89e3\u51b3\u4e25\u91cd\u7684\u79d1\u5b66\u95ee\u9898\u3002\u201d<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7136\u800c\uff0c\u5f53\u8c08\u5230\u4eba\u5de5\u667a\u80fd\u548c\u86cb\u767d\u8d28\u65f6\uff0c AlphaFold \u4ec5\u4ec5\u662f\u4e00\u4e2a\u5f00\u59cb\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">AlphaFold\u4e0d\u662f\u4f7f\u7528\u5927\u578b\u8bed\u8a00\u6a21\u578b\u6784\u5efa\u7684\u3002\u5b83\u4f9d\u8d56\u4e8e\u4e00\u79cd\u79f0\u4e3a\u591a\u91cd\u5e8f\u5217\u6bd4\u5bf9<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08MSA\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7684\u8f83\u65e7\u7684\u751f\u7269\u4fe1\u606f\u5b66\u7ed3\u6784\uff0c\u5176\u4e2d\u5c06\u86cb\u767d\u8d28\u7684\u5e8f\u5217\u4e0e\u8fdb\u5316\u4e0a\u76f8\u4f3c\u7684\u86cb\u767d\u8d28\u8fdb\u884c\u6bd4\u8f83\uff0c\u4ee5\u63a8\u65ad\u5176\u7ed3\u6784\u3002<br  \/>&nbsp;<br  \/>AlphaFold \u6240\u8868\u660e\u7684\u90a3\u6837\uff0cMSA \u975e\u5e38\u5f3a\u5927\uff0c\u4f46\u5b83\u4e5f\u6709\u5c40\u9650\u6027\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5176\u4e00\uff0c\u5b83\u901f\u5ea6\u6162\u4e14\u8ba1\u7b97\u91cf\u5927\uff0c\u56e0\u4e3a\u5b83\u9700\u8981\u53c2\u8003\u8bb8\u591a\u4e0d\u540c\u7684\u86cb\u767d\u8d28\u5e8f\u5217\u624d\u80fd\u786e\u5b9a\u4efb\u4f55\u4e00\u79cd\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u7531\u4e8e MSA \u9700\u8981\u5b58\u5728\u5927\u91cf\u8fdb\u5316\u548c\u7ed3\u6784\u76f8\u4f3c\u7684\u86cb\u767d\u8d28\u624d\u80fd\u63a8\u7406\u51fa\u65b0\u7684\u86cb\u767d\u8d28\u5e8f\u5217\uff0c\u56e0\u6b64\u5b83\u5bf9\u4e8e\u6240\u8c13\u7684\u201c\u5b64\u513f\u86cb\u767d\u8d28\u201d<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u51e0\u4e4e\u6ca1\u6709\u6216\u6ca1\u6709\u76f8\u4f3c\u7c7b\u4f3c\u7269\u7684\u86cb\u767d\u8d28\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7684\u7528\u9014\u6709\u9650\u3002\u8fd9\u4e9b\u5b64\u513f\u86cb\u767d\u5927\u7ea6\u5360\u6240\u6709\u5df2\u77e5\u86cb\u767d\u5e8f\u5217\u7684 20%\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u6700\u8fd1\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u59cb\u63a2\u7d22\u4e00\u79cd\u6709\u8da3\u7684\u66ff\u4ee3\u65b9\u6cd5\uff1a\u4f7f\u7528\u5927\u578b\u8bed\u8a00\u6a21\u578b\u800c\u4e0d\u662f\u591a\u91cd\u5e8f\u5217\u6bd4\u5bf9\u6765\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7ed3\u6784\u548c\u529f\u80fd\u4e4b\u95f4\u7684\u590d\u6742\u6a21\u5f0f\u548c\u76f8\u4e92\u5173\u7cfb\uff1a\u6bd4\u5982\uff0c\u5982\u4f55\u6539\u53d8\u86cb\u767d\u8d28\u67d0\u4e9b\u90e8\u5206\u7684\u67d0\u4e9b\u6c28\u57fa\u9178\u3002\u86cb\u767d\u8d28\u7684\u5e8f\u5217\u4f1a\u5f71\u54cd\u86cb\u767d\u8d28\u6298\u53e0\u7684\u5f62\u72b6\u3002\u5982\u679c\u60a8\u613f\u610f\uff0c\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u80fd\u591f\u5b66\u4e60\u86cb\u767d\u8d28\u7684\u8bed\u6cd5\u6216\u8bed\u8a00\u5b66\u3002<br  \/>&nbsp;<br  \/>\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u7684\u60f3\u6cd5\u53ef\u4ee5\u8ffd\u6eaf\u5230\u54c8\u4f5b\u5927\u5b66 George Church \u5b9e\u9a8c\u5ba42019 \u5e74UniRep \u7684\u5de5\u4f5c<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u5c3d\u7ba1UniRep\u4f7f\u7528 LSTM \u800c\u4e0d\u662f\u5f53\u4eca\u6700\u5148\u8fdb\u7684 Transformer \u6a21\u578b\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">2022 \u5e74\u5e95\uff0cMeta\u63a8\u51fa\u4e86ESM-2\u548cESMFold \uff0c\u8fd9\u662f\u8fc4\u4eca\u4e3a\u6b62\u53d1\u5e03\u7684\u6700\u5927\u3001\u6700\u590d\u6742\u7684\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u4e4b\u4e00\uff0c\u53c2\u6570\u8fbe 150 \u4ebf\u4e2a\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08ESM-2 \u662f LLM \u672c\u8eab\uff1bESMFold\u662f\u5176\u76f8\u5173\u7684\u7ed3\u6784\u9884\u6d4b\u5de5\u5177\u3002\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/>&nbsp;<br  \/>ESM-2\/ ESMFold\u5728\u9884\u6d4b\u86cb\u767d\u8d28\u4e09\u7ef4\u7ed3\u6784\u65b9\u9762\u4e0eAlphaFold\u5927\u81f4\u76f8\u540c\u3002\u4f46\u4e0eAlphaFold\u4e0d\u540c\u7684\u662f\uff0c\u5b83\u80fd\u591f\u57fa\u4e8e\u5355\u4e2a\u86cb\u767d\u8d28\u5e8f\u5217\u751f\u6210\u7ed3\u6784\uff0c\u800c\u4e0d\u9700\u8981\u4efb\u4f55\u7ed3\u6784\u4fe1\u606f\u4f5c\u4e3a\u8f93\u5165\u3002\u56e0\u6b64\uff0c\u5b83\u6bd4AlphaFold\u5feb60\u500d\u3002\u5f53\u7814\u7a76\u4eba\u5458\u5e0c\u671b\u5728\u86cb\u767d\u8d28\u5de5\u7a0b\u5de5\u4f5c\u6d41\u7a0b\u4e2d\u540c\u65f6\u7b5b\u9009\u6570\u767e\u4e07\u4e2a\u86cb\u767d\u8d28\u5e8f\u5217\u65f6\uff0c\u8fd9\u79cd\u901f\u5ea6\u4f18\u52bf\u4f1a\u4ea7\u751f\u5de8\u5927\u7684\u5dee\u5f02\u3002\u5bf9\u4e8e\u7f3a\u4e4f\u8fdb\u5316\u4e0a\u76f8\u4f3c\u7684\u7c7b\u4f3c\u7269\u7684\u5b64\u513f\u86cb\u767d\uff0c ESMFold \u8fd8\u53ef\u4ee5\u6bd4 AlphaFold \u4ea7\u751f\u66f4\u51c6\u786e\u7684\u7ed3\u6784\u9884\u6d4b\u3002<br  \/><\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u8bed\u8a00\u6a21\u578b\u80fd\u591f\u5bf9\u86cb\u767d\u8d28\u7684\u201c\u6f5c\u5728\u7a7a\u95f4\u201d\u4ea7\u751f\u666e\u904d\u7684\u7406\u89e3\uff0c\u8fd9\u4e3a\u86cb\u767d\u8d28\u79d1\u5b66\u5f00\u8f9f\u4e86\u4ee4\u4eba\u5174\u594b\u7684\u53ef\u80fd\u6027\u3002<br  \/>&nbsp;<br  \/>AlphaFold\u4ee5\u6765\u7684\u51e0\u5e74\u91cc\uff0c\u66f4\u5f3a\u5927\u7684\u6982\u5ff5\u8fdb\u6b65\u5df2\u7ecf\u53d1\u751f\u3002<\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;margin-bottom: 0px;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7b80\u800c\u8a00\u4e4b\uff0c\u8fd9\u4e9b\u86cb\u767d\u8d28\u6a21\u578b\u53ef\u4ee5\u9006\u8f6c\uff1a\u4e0d\u662f\u6839\u636e\u86cb\u767d\u8d28\u7684\u5e8f\u5217\u6765\u9884\u6d4b\u86cb\u767d\u8d28\u7684\u7ed3\u6784\uff0c\u800c\u662f\u53ef\u4ee5\u9006\u8f6cESM-2\u7b49\u6a21\u578b\uff0c\u5e76\u6839\u636e\u6240\u9700\u7684\u7279\u6027\u7528\u4e8e\u751f\u6210\u81ea\u7136\u754c\u4e2d\u4e0d\u5b58\u5728\u7684\u5168\u65b0\u86cb\u767d\u8d28\u5e8f\u5217\u3002<br  \/>&nbsp;<\/p>\n<p><\/span><\/section>\n<h3 style=\"outline: 0px;white-space: normal;letter-spacing: 0.544px;font-family: -apple-system, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;font-family: PingFangSC-light;text-align: right;font-size: 13px;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;letter-spacing: 0.544px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;\">\n<section style=\"outline: 0px;display: inline-block;vertical-align: middle;\">\n<section style=\"margin-bottom: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;clear: both;line-height: 0;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;border-left: 3px solid rgb(33, 166, 210);border-right: 3px solid rgb(33, 166, 210);border-top-color: rgb(33, 166, 210);border-bottom-color: rgb(33, 166, 210);font-size: 16px;color: rgb(0, 0, 0);line-height: 1.4;\">\n<p style=\"outline: 0px;\"><span style=\"outline: 0px;font-size: 17px;\"><strong style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\">\u53d1\u660e\u65b0\u86cb\u767d\u8d28<\/strong><\/strong><\/span><\/p>\n<\/section>\n<section style=\"margin-top: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;font-size: 16px;white-space: normal;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5f53\u4eca\u4e16\u754c\u4e0a\u5b58\u5728\u7684\u6240\u6709\u86cb\u767d\u8d28\u4ec5\u4ee3\u8868\u7406\u8bba\u4e0a\u53ef\u80fd\u5b58\u5728\u7684\u6240\u6709\u86cb\u767d\u8d28\u7684\u6781\u5c0f\u4e00\u90e8\u5206\u3002\u673a\u4f1a\u5c31\u5728\u4e8e\u6b64\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7ed9\u51fa\u4e00\u4e9b\u7c97\u7565\u7684\u6570\u5b57\uff1a\u4eba\u4f53\u4e2d\u5b58\u5728\u7684\u5168\u90e8\u86cb\u767d\u8d28<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u5373\u6240\u8c13\u7684\u201c\u4eba\u7c7b\u86cb\u767d\u8d28\u7ec4\u201d\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u4f30\u8ba1\u6709 80,000 \u5230 400,000 \u79cd\u86cb\u767d\u8d28\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u7406\u8bba\u4e0a\u53ef\u80fd\u5b58\u5728\u7684\u86cb\u767d\u8d28\u6570\u91cf\u7ea6\u4e3a10<span style=\"font-size:12px;\"><sup>1300<\/sup><\/span>\uff0c\u8fd9\u662f\u4e00\u4e2a\u5927\u5f97\u96be\u4ee5\u60f3\u8c61\u7684\u6570\u5b57\uff0c\u6bd4\u5b87\u5b99\u4e2d\u539f\u5b50\u7684\u6570\u91cf\u8fd8\u8981\u591a\u5f88\u591a\u500d\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u9700\u8981\u660e\u786e\u7684\u662f\uff0c\u5e76\u975e\u6240\u6709\u8fd9 10<span style=\"font-size:12px;\"><sup>1300<\/sup><\/span> \u79cd\u53ef\u80fd\u7684\u6c28\u57fa\u9178\u7ec4\u5408\u90fd\u4f1a\u4ea7\u751f\u751f\u7269\u5b66\u4e0a\u53ef\u884c\u7684\u86cb\u767d\u8d28\u3002\u8fdc\u975e\u5982\u6b64\u3002\u4f46\u67d0\u4e9b\u5b50\u96c6\u4f1a\u3002\uff09<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u6570\u767e\u4e07\u5e74\u6765\uff0c\u873f\u8712\u7684\u8fdb\u5316\u8fc7\u7a0b\u5076\u7136\u53d1\u73b0\u4e86\u6570\u4e07\u6216\u6570\u5341\u4e07\u79cd\u8fd9\u6837\u7684\u53ef\u884c\u7ec4\u5408\u3002\u4f46\u8fd9\u53ea\u662f\u51b0\u5c71\u4e00\u89d2\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7528\u9886\u5148\u7684\u86cb\u767d\u8d28\u4eba\u5de5\u667a\u80fd\u521d\u521b\u516c\u53f8Generate Biomedicines\u7684\u8054\u5408\u521b\u59cb\u4eba\u83ab\u8389\u00b7\u5409\u5e03\u68ee<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08Molly Gibson\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7684\u8bdd\u6765\u8bf4\uff1a\u201c\u5927\u81ea\u7136\u5728\u751f\u547d\u5386\u53f2\u4e2d\u91c7\u6837\u7684\u5e8f\u5217\u7a7a\u95f4\u91cf\u51e0\u4e4e\u76f8\u5f53\u4e8e\u5730\u7403\u6240\u6709\u6d77\u6d0b\u4e2d\u7684\u4e00\u6ef4\u6c34\u3002\u201d<br  \/>&nbsp;<br  \/>\u6211\u4eec\u6709\u673a\u4f1a\u6539\u5584\u81ea\u7136\u3002\u6bd5\u7adf\uff0c\u5c3d\u7ba1\u81ea\u7136\u9009\u62e9\u7684\u8fdb\u5316\u529b\u91cf\u975e\u5e38\u5f3a\u5927\uff0c\u4f46\u5b83\u5e76\u4e0d\u662f\u65e0\u6240\u4e0d\u80fd\u7684\u3002\u5b83\u4e0d\u63d0\u524d\u8ba1\u5212\uff1b\u5b83\u4e0d\u4f1a\u4ee5\u81ea\u4e0a\u800c\u4e0b\u7684\u65b9\u5f0f\u8fdb\u884c\u63a8\u7406\u6216\u4f18\u5316\u3002\u5b83\u968f\u673a\u4e14\u673a\u4f1a\u4e3b\u4e49\u5730\u5c55\u5f00\uff0c\u4f20\u64ad\u6070\u597d\u6709\u6548\u7684\u7ec4\u5408\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u4f7f\u7528\u4eba\u5de5\u667a\u80fd\uff0c\u6211\u4eec\u53ef\u4ee5\u7b2c\u4e00\u6b21\u7cfb\u7edf\u5730\u3001\u5168\u9762\u5730\u63a2\u7d22\u86cb\u767d\u8d28\u7a7a\u95f4\u7684\u5e7f\u9614\u672a\u77e5\u9886\u57df\uff0c\u4ee5\u4fbf\u8bbe\u8ba1\u51fa\u4e0d\u540c\u4e8e\u81ea\u7136\u754c\u4e2d\u66fe\u7ecf\u5b58\u5728\u7684\u4efb\u4f55\u86cb\u767d\u8d28\uff0c\u4e13\u4e3a\u6211\u4eec\u7684\u533b\u7597\u548c\u5546\u4e1a\u9700\u6c42\u800c\u8bbe\u8ba1\u3002<br  \/>&nbsp;<br  \/>\u6211\u4eec\u5c06\u80fd\u591f\u8bbe\u8ba1\u65b0\u7684\u86cb\u767d\u8d28\u7597\u6cd5\u6765\u89e3\u51b3\u6240\u6709\u4eba\u7c7b\u75be\u75c5\u2014\u2014\u4ece\u764c\u75c7\u5230\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u4ece\u7cd6\u5c3f\u75c5\u5230\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3002\u9664\u4e86\u533b\u5b66\u4e4b\u5916\uff0c\u6211\u4eec\u5c06\u80fd\u591f\u521b\u9020\u51fa\u65b0\u578b\u86cb\u767d\u8d28\uff0c\u5e76\u5728\u519c\u4e1a\u3001\u5de5\u4e1a\u3001\u6750\u6599\u79d1\u5b66\u3001\u73af\u5883\u4fee\u590d\u7b49\u9886\u57df\u5177\u6709\u9769\u547d\u6027\u7684\u5e94\u7528\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u4e00\u4e9b\u5229\u7528\u6df1\u5ea6\u5b66\u4e60\u8fdb\u884c\u4ece\u5934\u86cb\u767d\u8d28\u8bbe\u8ba1\u7684\u65e9\u671f\u52aa\u529b\u5e76\u672a\u5229\u7528\u5927\u578b\u8bed\u8a00\u6a21\u578b\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u4e00\u4e2a\u7a81\u51fa\u7684\u4f8b\u5b50\u662fProteinMPNN \uff0c\u5b83\u6765\u81ea\u534e\u76db\u987f\u5927\u5b66\u4e16\u754c\u8457\u540d\u7684 David Baker \u5b9e\u9a8c\u5ba4\u3002ProteinMPNN\u67b6\u6784\u4e0d\u4f7f\u7528 LLM\uff0c\u800c\u662f\u4e25\u91cd\u4f9d\u8d56\u86cb\u767d\u8d28\u7ed3\u6784\u6570\u636e\u6765\u751f\u6210\u65b0\u86cb\u767d\u8d28\u3002<br  \/>&nbsp;<br  \/>Baker \u5b9e\u9a8c\u5ba4\u6700\u8fd1\u53d1\u5e03\u4e86RFdiffusion \uff0c\u8fd9\u662f\u4e00\u79cd\u66f4\u5148\u8fdb\u3001\u66f4\u901a\u7528\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u6a21\u578b\u3002\u987e\u540d\u601d\u4e49\uff0c RFdiffusion \u662f\u4f7f\u7528\u6269\u6563\u6a21\u578b\u6784\u5efa\u7684\uff0c\u8fd9\u79cd\u4eba\u5de5\u667a\u80fd\u6280\u672f\u4e5f\u4e3aMidjourney \u548c Stable Diffusion \u7b49\u6587\u672c\u5230\u56fe\u50cf\u6a21\u578b\u63d0\u4f9b\u652f\u6301\u3002RFdiffusion\u53ef\u4ee5\u751f\u6210\u65b0\u9896\u7684\u3001\u53ef\u5b9a\u5236\u7684\u86cb\u767d\u8d28\u201c\u9aa8\u67b6\u201d\uff0c\u5373\u86cb\u767d\u8d28\u7684\u6574\u4f53\u7ed3\u6784\u652f\u67b6\uff0c\u7136\u540e\u53ef\u4ee5\u5c06\u5e8f\u5217\u5206\u5c42\u5230\u5176\u4e0a\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">ProteinMPNN\u548cRFdiffusion\u7b49\u4ee5\u7ed3\u6784\u4e3a\u4e2d\u5fc3\u7684\u6a21\u578b\u53d6\u5f97\u4e86\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u6210\u5c31\uff0c\u63a8\u52a8\u4e86\u57fa\u4e8e\u4eba\u5de5\u667a\u80fd\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u7684\u6700\u5148\u8fdb\u6c34\u5e73\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5927\u578b\u8bed\u8a00\u6a21\u578b\u7684\u53d8\u9769\u80fd\u529b\uff0c\u6211\u4eec\u53ef\u80fd\u6b63\u5904\u4e8e\u8be5\u9886\u57df\u65b0\u7684\u53d8\u9769\u7684\u98ce\u53e3\u6d6a\u5c16\u3002<br  \/>&nbsp;<br  \/>\u4e0e\u86cb\u767d\u8d28\u8bbe\u8ba1\u7684\u5176\u4ed6\u8ba1\u7b97\u65b9\u6cd5\u76f8\u6bd4\uff0c\u4e3a\u4ec0\u4e48\u8bed\u8a00\u6a21\u578b\u662f\u4e00\u6761\u5982\u6b64\u6709\u524d\u9014\u7684\u9053\u8def\uff1f\u5173\u952e\u539f\u56e0\u4e4b\u4e00\uff1a\u89c4\u6a21\u5316\uff08scaling\uff09\u3002<br  \/>&nbsp;<br  \/><\/span><\/p>\n<h3 style=\"outline: 0px;white-space: normal;letter-spacing: 0.544px;font-family: -apple-system, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;font-family: PingFangSC-light;text-align: right;font-size: 13px;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;letter-spacing: 0.544px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;\">\n<section style=\"outline: 0px;display: inline-block;vertical-align: middle;\">\n<section style=\"margin-bottom: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;clear: both;line-height: 0;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;border-left: 3px solid rgb(33, 166, 210);border-right: 3px solid rgb(33, 166, 210);border-top-color: rgb(33, 166, 210);border-bottom-color: rgb(33, 166, 210);font-size: 16px;color: rgb(0, 0, 0);line-height: 1.4;\">\n<p style=\"outline: 0px;\"><span style=\"outline: 0px;font-size: 17px;\"><strong style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\">\u6807\u5ea6\u5f8b<\/strong><\/strong><\/span><\/p>\n<\/section>\n<section style=\"margin-top: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;font-size: 16px;white-space: normal;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u4eba\u5de5\u667a\u80fd\u8fd1\u671f\u53d6\u5f97\u7684\u5de8\u5927\u8fdb\u5c55\u80cc\u540e\u7684\u5173\u952e\u529b\u91cf\u4e4b\u4e00\u662f\u6240\u8c13\u7684\u201c\u6807\u5ea6\u5f8b\u201d\uff08Scaling law\uff09 \uff1a\u4e8b\u5b9e\u4e0a\uff0cLLM \u53c2\u6570\u6570\u91cf\u3001\u8bad\u7ec3\u6570\u636e\u548c\u8ba1\u7b97\u7684\u6301\u7eed\u589e\u52a0\u5e26\u6765\u4e86\u51e0\u4e4e\u4ee4\u4eba\u96be\u4ee5\u7f6e\u4fe1\u7684\u6027\u80fd\u63d0\u5347\u3002<br  \/>&nbsp;<br  \/>\u5728\u89c4\u6a21\u6bcf\u589e\u52a0\u4e00\u4e2a\u6570\u91cf\u7ea7\u65f6\uff0c\u8bed\u8a00\u6a21\u578b\u90fd\u8868\u73b0\u51fa\u4e86\u975e\u51e1\u7684\u3001\u610f\u60f3\u4e0d\u5230\u7684\u3001\u65b0\u5174\u7684\u65b0\u80fd\u529b\uff0c\u8d85\u8d8a\u4e86\u8f83\u5c0f\u89c4\u6a21\u4e0b\u7684\u53ef\u80fd\u6027\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u8fd1\u5e74\u6765\uff0c\u6b63\u662fOpenAI\u5bf9\u6269\u5c55\u539f\u5219\u7684\u627f\u8bfa\uff0c\u4f7f\u8be5\u7ec4\u7ec7\u8dfb\u8eab\u4eba\u5de5\u667a\u80fd\u9886\u57df\u7684\u6700\u524d\u6cbf\u3002\u968f\u7740OpenAI\u4ece GPT-2 \u8f6c\u5411 GPT-3\u3001GPT-4 \u53ca\u66f4\u9ad8\u7248\u672c\uff0c\u4ed6\u4eec\u6784\u5efa\u4e86\u66f4\u5927\u7684\u6a21\u578b\uff0c\u90e8\u7f72\u4e86\u66f4\u591a\u7684\u8ba1\u7b97\uff0c\u5e76\u5728\u66f4\u5927\u7684\u6570\u636e\u96c6\u4e0a\u8fdb\u884c\u4e86\u8bad\u7ec3\uff0c\u6bd4\u4e16\u754c\u4e0a\u4efb\u4f55\u5176\u4ed6\u7ec4\u7ec7\u90fd\u89e3\u9501\u4e86\u4ee4\u4eba\u60ca\u53f9\u7684\u3001\u524d\u6240\u672a\u6709\u7684 AI \u529f\u80fd\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u6807\u5ea6\u5f8b\u4e0e\u86cb\u767d\u8d28\u9886\u57df\u6709\u4f55\u5173\u7cfb\uff1f<br  \/><\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u8fc7\u53bb\u4e8c\u5341\u5e74\u6765\uff0c\u79d1\u5b66\u7a81\u7834\u4f7f\u5f97\u57fa\u56e0\u6d4b\u5e8f\u53d8\u5f97\u66f4\u52a0\u4fbf\u5b9c\u4e14\u66f4\u5bb9\u6613\u83b7\u5f97\uff0c\u53ef\u7528\u4e8e\u8bad\u7ec3\u4eba\u5de5\u667a\u80fd\u6a21\u578b\u7684 DNA \u548c\u86cb\u767d\u8d28\u5e8f\u5217\u6570\u636e\u7684\u6570\u91cf\u5448\u6307\u6570\u7ea7\u589e\u957f\uff0c\u8fdc\u8fdc\u8d85\u8fc7\u4e86\u86cb\u767d\u8d28\u7ed3\u6784\u6570\u636e\u3002<br  \/>&nbsp;<br  \/>\u86cb\u767d\u8d28\u5e8f\u5217\u6570\u636e\u53ef\u4ee5\u88ab\u6807\u8bb0\u5316\uff0c\u5e76\u4e14\u51fa\u4e8e\u6240\u6709\u610f\u56fe\u548c\u76ee\u7684\u88ab\u89c6\u4e3a\u6587\u672c\u6570\u636e\uff1b\u6bd5\u7adf\uff0c\u5b83\u7531\u6309\u4e00\u5b9a\u987a\u5e8f\u6392\u5217\u7684\u7ebf\u6027\u6c28\u57fa\u9178\u4e32\u7ec4\u6210\uff0c\u5c31\u50cf\u53e5\u5b50\u4e2d\u7684\u5355\u8bcd\u4e00\u6837\u3002\u5927\u578b\u8bed\u8a00\u6a21\u578b\u53ef\u4ee5\u4ec5\u9488\u5bf9\u86cb\u767d\u8d28\u5e8f\u5217\u8fdb\u884c\u8bad\u7ec3\uff0c\u4ee5\u6df1\u5165\u4e86\u89e3\u86cb\u767d\u8d28\u7ed3\u6784\u548c\u751f\u7269\u5b66\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u56e0\u6b64\uff0c\u8fd9\u4e2a\u9886\u57df\u5df2\u7ecf\u6210\u719f\uff0c\u53ef\u4ee5\u8fdb\u884c\u7531<span style=\"color: rgb(63, 63, 63);font-size: 15px;letter-spacing: 0.578px;text-wrap: wrap;\">\u5927\u8bed\u8a00\u6a21\u578b<\/span>\u652f\u6301\u7684\u5927\u89c4\u6a21\u6269\u5c55\u5de5\u4f5c\uff0c\u8fd9\u4e9b\u52aa\u529b\u53ef\u80fd\u4f1a\u5728\u86cb\u767d\u8d28\u79d1\u5b66\u9886\u57df\u5e26\u6765\u60ca\u4eba\u7684\u65b0\u89c1\u89e3\u548c\u80fd\u529b\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7b2c\u4e00\u4e2a\u4f7f\u7528\u57fa\u4e8e Transformer \u7684LLM \u6765\u8bbe\u8ba1\u4ece\u5934\u86cb\u767d\u8d28\u7684\u4f5c\u54c1\u662fSalesforce Research \u4e8e 2020 \u5e74\u53d1\u8868\u7684ProGen \u3002\u6700\u521d\u7684ProGen\u6a21\u578b\u6709 12 \u4ebf\u4e2a\u53c2\u6570\u3002<br  \/>&nbsp;<br  \/>ProGen\u7684\u9996\u5e2d\u7814\u7a76\u5458Ali Madani\u6b64\u540e\u6210\u7acb\u4e86\u4e00\u5bb6\u540d\u4e3a Profluu Bio \u7684\u521d\u521b\u516c\u53f8\uff0c\u4ee5\u63a8\u8fdb<span style=\"color: rgb(63, 63, 63);font-size: 15px;letter-spacing: 0.578px;text-wrap: wrap;\">\u5927\u8bed\u8a00\u6a21\u578b<\/span>\u9a71\u52a8\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u5e76\u5c06\u5176\u5546\u4e1a\u5316\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Madani\u7387\u5148\u4f7f\u7528<span style=\"color: rgb(63, 63, 63);font-size: 15px;letter-spacing: 0.578px;text-wrap: wrap;\">\u5927\u8bed\u8a00\u6a21\u578b<\/span>\u8fdb\u884c\u86cb\u767d\u8d28\u8bbe\u8ba1\uff0c\u4f46\u4ed6\u4e5f\u6e05\u695a\u5730\u610f\u8bc6\u5230\uff0c\u4ec5\u9760\u539f\u59cb\u86cb\u767d\u8d28\u5e8f\u5217\u8bad\u7ec3\u7684\u73b0\u6210\u8bed\u8a00\u6a21\u578b\u5e76\u4e0d\u662f\u5e94\u5bf9\u8fd9\u4e00\u6311\u6218\u7684\u6700\u6709\u529b\u65b9\u6cd5\u3002\u7ed3\u5408\u7ed3\u6784\u548c\u529f\u80fd\u6570\u636e\u81f3\u5173\u91cd\u8981\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u201c\u86cb\u767d\u8d28\u8bbe\u8ba1\u7684\u6700\u5927\u8fdb\u6b65\u5c06\u5728\u4e8e\u6765\u81ea\u4e0d\u540c\u6765\u6e90\u7684\u4ed4\u7ec6\u6570\u636e\u7ba1\u7406\u548c\u53ef\u4ee5\u7075\u6d3b\u5730\u4ece\u8fd9\u4e9b\u6570\u636e\u4e2d\u5b66\u4e60\u7684\u901a\u7528\u6a21\u578b\u7684\u4ea4\u53c9\u70b9\uff0c\u201d\u9a6c\u8fbe\u5c3c\u8bf4\u3002\u201c\u8fd9\u9700\u8981\u5229\u7528\u6211\u4eec\u638c\u63e1\u7684\u6240\u6709\u9ad8\u4fe1\u53f7\u6570\u636e\uff0c\u5305\u62ec\u6765\u81ea\u5b9e\u9a8c\u5ba4\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u548c\u529f\u80fd\u4fe1\u606f\u3002\u201d<br  \/>&nbsp;<br  \/>Nabla Bio\u662f\u53e6\u4e00\u5bb6\u5e94\u7528<span style=\"color: rgb(63, 63, 63);font-size: 15px;letter-spacing: 0.578px;text-wrap: wrap;\">\u5927\u8bed\u8a00\u6a21\u578b<\/span>\u8bbe\u8ba1\u65b0\u578b\u86cb\u767d\u8d28\u7597\u6cd5\u7684\u6709\u8da3\u7684\u65e9\u671f\u521d\u521b\u516c\u53f8\u3002Nabla\u662f\u4ece\u54c8\u4f5b\u5927\u5b66 George Church \u5b9e\u9a8c\u5ba4\u5206\u79bb\u51fa\u6765\u7684\uff0c\u7531UniRep\u80cc\u540e\u7684\u56e2\u961f\u9886\u5bfc\uff0c\u4e13\u95e8\u4e13\u6ce8\u4e8e\u6297\u4f53\u7814\u7a76\u3002\u9274\u4e8e\u5f53\u4eca 60% \u7684\u86cb\u767d\u8d28\u6cbb\u7597\u836f\u7269\u90fd\u662f\u6297\u4f53\uff0c\u5e76\u4e14\u4e16\u754c\u4e0a\u6700\u7545\u9500\u7684\u4e24\u79cd\u836f\u7269\u90fd\u662f\u6297\u4f53\u6cbb\u7597\u836f\u7269\uff0c\u56e0\u6b64\u9009\u62e9\u8fd9\u4e00\u9009\u62e9\u5e76\u4e0d\u4ee4\u4eba\u610f\u5916\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Nabla\u51b3\u5b9a\u4e0d\u5f00\u53d1\u81ea\u5df1\u7684\u7597\u6cd5\uff0c\u800c\u662f\u5411\u751f\u7269\u5236\u836f\u5408\u4f5c\u4f19\u4f34\u63d0\u4f9b\u5176\u5c16\u7aef\u6280\u672f\uff0c\u4f5c\u4e3a\u5e2e\u52a9\u4ed6\u4eec\u5f00\u53d1\u81ea\u5df1\u7684\u836f\u7269\u7684\u5de5\u5177\u3002<\/span><\/p>\n<section style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;margin-bottom: 0px;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u968f\u7740\u4e16\u754c\u9010\u6e10\u8ba4\u8bc6\u5230\u86cb\u767d\u8d28\u8bbe\u8ba1\u662f\u4e00\u4e2a\u5de8\u5927\u4e14\u5c1a\u672a\u5145\u5206\u5f00\u53d1\u7684\u9886\u57df\uff0c\u53ef\u4ee5\u5728\u5176\u4e2d\u5e94\u7528\u5927\u578b\u8bed\u8a00\u6a21\u578b\u770b\u4f3c\u795e\u5947\u7684\u529f\u80fd\uff0c\u9884\u8ba1\u672a\u6765\u6570\u6708\u4e43\u81f3\u6570\u5e74\u8be5\u9886\u57df\u5c06\u51fa\u73b0\u66f4\u591a\u7684\u521b\u4e1a\u6d3b\u52a8\u3002<br  \/>&nbsp;<\/p>\n<p><\/span><\/section>\n<h3 style=\"outline: 0px;white-space: normal;letter-spacing: 0.544px;font-family: -apple-system, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;letter-spacing: 0.544px;font-family: PingFangSC-light;text-align: right;font-size: 13px;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;letter-spacing: 0.544px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;\">\n<section style=\"outline: 0px;display: inline-block;vertical-align: middle;\">\n<section style=\"margin-bottom: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;clear: both;line-height: 0;\">\n<section style=\"outline: 0px;line-height: 0;width: 0px;\"><svg viewbox=\"0 0 1 1\" style=\"vertical-align:top;\"><\/svg><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;border-left: 3px solid rgb(33, 166, 210);border-right: 3px solid rgb(33, 166, 210);border-top-color: rgb(33, 166, 210);border-bottom-color: rgb(33, 166, 210);font-size: 16px;color: rgb(0, 0, 0);line-height: 1.4;\">\n<p style=\"outline: 0px;\"><span style=\"outline: 0px;font-size: 17px;\"><strong style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\">\u524d\u65b9\u7684\u8def<\/strong><\/strong><\/span><\/p>\n<\/section>\n<section style=\"margin-top: -2px;outline: 0px;\">\n<section style=\"outline: 0px;float: left;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<section style=\"outline: 0px;float: right;width: 8px;height: 3px;background-color: rgb(33, 166, 210);line-height: 0;\"><br style=\"outline: 0px;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;font-size: 16px;white-space: normal;line-height: 1.75em;\"><br style=\"outline: 0px;font-family: system-ui, -apple-system, &quot;system-ui&quot;, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5f17\u6717\u897f\u65af\u00b7\u963f\u8bfa\u5fb7<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\"> (Frances Arnold) <\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5728 2018 \u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u83b7\u5956\u611f\u8a00\u4e2d\u8868\u793a\uff1a\u201c\u4eca\u5929\uff0c\u6211\u4eec\u53ef\u4ee5\u51fa\u4e8e\u5404\u79cd\u5b9e\u9645\u76ee\u7684\u8bfb\u53d6\u3001\u5199\u5165\u548c\u7f16\u8f91\u4efb\u4f55 DNA \u5e8f\u5217\uff0c\u4f46\u6211\u4eec\u65e0\u6cd5\u5408\u6210\u5b83\u3002\u751f\u547d\u7684\u5bc6\u7801\u662f\u4e00\u9996\u4ea4\u54cd\u4e50\uff0c\u5f15\u5bfc\u7740\u65e0\u6570\u6f14\u594f\u8005\u548c\u4e50\u5668\u6f14\u594f\u51fa\u590d\u6742\u800c\u4f18\u7f8e\u7684\u90e8\u5206\u3002\u4e5f\u8bb8\u6211\u4eec\u53ef\u4ee5\u4ece\u5927\u81ea\u7136\u7684\u6210\u5206\u4e2d\u526a\u5207\u548c\u7c98\u8d34\u7247\u6bb5\uff0c\u4f46\u6211\u4eec\u4e0d\u77e5\u9053\u5982\u4f55\u4e3a\u5355\u4e2a\u9176\u901a\u9053\u5199\u51fa\u6761\u5f62\u3002\u201d<br  \/>&nbsp;<br  \/>\u5c31\u5728\u4e94\u5e74\u524d\uff0c\u8fd9\u4e5f\u662f\u4e8b\u5b9e\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u4f46\u4eba\u5de5\u667a\u80fd\u53ef\u80fd\u5728\u751f\u547d\u53f2\u4e0a\u7b2c\u4e00\u6b21\u8ba9\u6211\u4eec\u6709\u80fd\u529b\u4ece\u5934\u5f00\u59cb\u771f\u6b63\u6784\u5efa\u5168\u65b0\u7684\u86cb\u767d\u8d28<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\uff08\u53ca\u5176\u76f8\u5173\u7684\u9057\u4f20\u5bc6\u7801\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\uff0c\u4e13\u95e8\u4e3a\u6211\u4eec\u7684\u9700\u6c42\u800c\u6784\u5efa\u3002\u8fd9\u662f\u4e00\u4e2a\u4ee4\u4eba\u60ca\u53f9\u7684\u53ef\u80fd\u6027\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u8fd9\u4e9b\u65b0\u578b\u86cb\u767d\u8d28\u5c06\u4f5c\u4e3a\u591a\u79cd\u4eba\u7c7b\u75be\u75c5\u7684\u6cbb\u7597\u836f\u7269\uff0c\u4ece\u4f20\u67d3\u75c5\u5230\u764c\u75c7\uff1b\u4ed6\u4eec\u5c06\u5e2e\u52a9\u57fa\u56e0\u7f16\u8f91\u6210\u4e3a\u73b0\u5b9e\uff1b\u4ed6\u4eec\u5c06\u6539\u53d8\u6750\u6599\u79d1\u5b66\uff1b\u5b83\u4eec\u5c06\u63d0\u9ad8\u519c\u4e1a\u4ea7\u91cf\uff1b\u5b83\u4eec\u5c06\u4e2d\u548c\u73af\u5883\u4e2d\u7684\u6c61\u67d3\u7269\uff1b\u4ee5\u53ca\u66f4\u591a\u6211\u4eec\u751a\u81f3\u65e0\u6cd5\u60f3\u8c61\u7684\u4e8b\u60c5\u3002<br  \/>&nbsp;<br  \/>\u4eba\u5de5\u667a\u80fd\u9a71\u52a8<\/span><span style=\"color: rgb(136, 136, 136);font-size: 15px;\">\uff08\u5c24\u5176\u662f<span style=\"font-size: 15px;letter-spacing: 0.578px;text-wrap: wrap;\">\u5927\u8bed\u8a00\u6a21\u578b<\/span>\u9a71\u52a8\uff09<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u9886\u57df\u4ecd\u5904\u4e8e\u65b0\u751f\u9636\u6bb5\u4e14\u672a\u7ecf\u8bc1\u5b9e\u3002\u6709\u610f\u4e49\u7684<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u79d1\u5b66\u3001\u5de5\u7a0b\u3001\u4e34\u5e8a\u548c\u5546\u4e1a\u969c\u788d\u4ecd\u7136\u5b58\u5728\u3002\u5c06\u8fd9\u4e9b\u65b0\u7597\u6cd5\u548c\u4ea7\u54c1\u63a8\u5411\u5e02\u573a\u9700\u8981\u6570\u5e74\u65f6\u95f4\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u4f46\u4ece\u957f\u8fdc\u6765\u770b\uff0c\u4eba\u5de5\u667a\u80fd\u7684\u5e02\u573a\u5e94\u7528\u5f88\u5c11\u6709\u6bd4\u8fd9\u66f4\u5177\u6709\u524d\u666f\u7684\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5728\u672a\u6765\u7684\u6587\u7ae0\u4e2d\uff0c\u6211\u4eec\u5c06\u6df1\u5165\u7814\u7a76\u86cb\u767d\u8d28\u8bbe\u8ba1\u7684<\/span><span style=\"color: rgb(63, 63, 63);font-size: 15px;letter-spacing: 0.578px;text-wrap: wrap;\">\u5927\u8bed\u8a00\u6a21\u578b<\/span><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\uff0c\u5305\u62ec\u63a2\u7d22\u8be5\u6280\u672f\u6700\u5f15\u4eba\u6ce8\u76ee\u7684\u5546\u4e1a\u5e94\u7528\uff0c\u4ee5\u53ca\u8ba1\u7b97\u7ed3\u679c\u548c\u73b0\u5b9e\u4e16\u754c\u6e7f\u5b9e\u9a8c\u5ba4\u5b9e\u9a8c\u4e4b\u95f4\u7684\u590d\u6742\u5173\u7cfb\u3002<br  \/>&nbsp;<br  \/>\u4ece\u5934\u86cb\u767d\u8d28\u8bbe\u8ba1\u5e76\u4e0d\u662f\u751f\u547d\u79d1\u5b66\u4e2d\u5927\u578b\u8bed\u8a00\u6a21\u578b\u552f\u4e00\u4ee4\u4eba\u5174\u594b\u7684\u673a\u4f1a\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u8bed\u8a00\u6a21\u578b\u53ef\u7528\u4e8e\u751f\u6210\u5176\u4ed6\u7c7b\u522b\u7684\u751f\u7269\u5206\u5b50\uff0c\u7279\u522b\u662f\u6838\u9178\u3002\u4f8b\u5982\uff0c\u4e00\u5bb6\u540d\u4e3a Inceptive \u7684\u70ed\u95e8\u521d\u521b\u516c\u53f8\u6b63\u5728\u5e94\u7528<span style=\"color: rgb(63, 63, 63);font-size: 15px;letter-spacing: 0.578px;text-wrap: wrap;\">\u5927\u8bed\u8a00\u6a21\u578b<\/span>\u6765\u5f00\u53d1\u65b0\u578b RNA \u7597\u6cd5\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u5176\u4ed6\u56e2\u4f53\u6709\u7740\u66f4\u5e7f\u6cdb\u7684\u613f\u671b\uff0c\u65e8\u5728\u5efa\u7acb\u901a\u7528\u7684\u201c\u751f\u7269\u5b66\u57fa\u7840\u6a21\u578b\u201d\uff0c\u53ef\u4ee5\u878d\u5408\u57fa\u56e0\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u5e8f\u5217\u3001\u7ec6\u80de\u7ed3\u6784\u3001\u8868\u89c2\u9057\u4f20\u72b6\u6001\u3001\u7ec6\u80de\u56fe\u50cf\u3001\u8d28\u8c31\u3001\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u7b49\u591a\u79cd\u6570\u636e\u7c7b\u578b\u3002<br  \/>&nbsp;<br  \/>\u6700\u7ec8\u76ee\u6807\u662f\u8d85\u8d8a\u5bf9\u86cb\u767d\u8d28\u7b49\u5355\u4e2a\u5206\u5b50\u7684\u5efa\u6a21\uff0c\u8f6c\u800c\u5bf9\u86cb\u767d\u8d28\u4e0e\u5176\u4ed6\u5206\u5b50\u7684\u76f8\u4e92\u4f5c\u7528\u8fdb\u884c\u5efa\u6a21\uff0c\u7136\u540e\u5bf9\u6574\u4e2a\u7ec6\u80de\u3001\u7ec4\u7ec7\u3001\u5668\u5b98\u8fdb\u884c\u5efa\u6a21\uff0c\u6700\u7ec8\u5bf9\u6574\u4e2a\u751f\u7269\u4f53\u8fdb\u884c\u5efa\u6a21\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u8bbe\u8ba1\u590d\u6742\u751f\u7269\u7cfb\u7edf\u7684\u6bcf\u4e00\u4e2a\u590d\u6742\u7ec6\u8282\u7684\u4eba\u5de5\u667a\u80fd\u7cfb\u7edf\u7684\u60f3\u6cd5\u662f\u4ee4\u4eba\u96be\u4ee5\u7f6e\u4fe1\u7684\u3002\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u8fd9\u5c06\u5728\u6211\u4eec\u7684\u638c\u63e1\u4e4b\u4e2d\u3002<br  \/>&nbsp;<br  \/>\u4e8c\u5341\u4e16\u7eaa\u662f\u7531\u7269\u7406\u5b66\u7684\u57fa\u672c\u8fdb\u6b65\u5b9a\u4e49\u7684\uff1a\u4ece\u963f\u5c14\u4f2f\u7279\u00b7\u7231\u56e0\u65af\u5766\u7684\u76f8\u5bf9\u8bba\u5230\u91cf\u5b50\u529b\u5b66\u7684\u53d1\u73b0\uff0c\u4ece\u6838\u5f39\u5230\u6676\u4f53\u7ba1\u3002\u6b63\u5982\u8bb8\u591a\u73b0\u4ee3\u89c2\u5bdf\u5bb6\u6240\u6307\u51fa\u7684\uff0c\u4e8c\u5341\u4e00\u4e16\u7eaa\u6b63\u5728\u6210\u4e3a\u751f\u7269\u5b66\u7684\u4e16\u7eaa\u3002\u4eba\u5de5\u667a\u80fd\u548c\u5927\u578b\u8bed\u8a00\u6a21\u578b\u5c06\u5728\u672a\u6765\u51e0\u5341\u5e74\u89e3\u5f00\u751f\u7269\u5b66\u7684\u79d8\u5bc6\u5e76\u91ca\u653e\u5176\u53ef\u80fd\u6027\u65b9\u9762\u53d1\u6325\u6838\u5fc3\u4f5c\u7528\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u7cfb\u597d\u5b89\u5168\u5e26\u3002<\/span><\/p>\n<\/section>\n<h1 style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;margin-bottom: 0px;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/h1>\n<section style=\"text-align: center;margin-bottom: 0px;\"><img class=\"rich_pages wxw-img\" data-galleryid=\"\" data-ratio=\"0.36349693251533743\" data-s=\"300,640\" data-type=\"png\" data-w=\"652\" style=\"height: auto !important;\"  src=\"\/wp-content\/uploads\/2023\/08\/wxsync-2023-08-773597fb5e2885aabf19396bdb247bfe.png\"  \/><\/section>\n<blockquote class=\"js_blockquote_wrap\" data-type=\"2\" data-url=\"\" data-author-name=\"\" data-content-utf8-length=\"160\" data-source-title=\"\" data-text=\"\u539f\u6587\u9898\u76ee\uff1aThe Next Frontier For Large Language Models Is Biology\u539f\u6587\u5730\u5740\uff1ahttps:\/\/www.forbes.com\/sites\/robtoews\/2023\/07\/16\/the-next-frontier-for-large-language-models-is-biology\/\" data-editid=\"351mwlzhzp1msr4utc\">\n<section class=\"js_blockquote_digest\">\n<section>\n<h1 style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;margin-bottom: 0px;text-align: left;\"><span style=\"color: rgb(136, 136, 136);font-size: 15px;\">\u539f\u6587\u9898\u76ee\uff1a<\/span><\/h1>\n<h1 style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;margin-bottom: 0px;text-align: left;\"><span style=\"color: rgb(136, 136, 136);font-size: 15px;\">The Next Frontier For Large Language Models Is Biology<\/span><\/h1>\n<h1 style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;margin-bottom: 0px;text-align: left;\"><span style=\"color: rgb(136, 136, 136);font-size: 15px;\">\u539f\u6587\u5730\u5740<span style=\"color: rgb(136, 136, 136);letter-spacing: 0.578px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\">\uff1a<\/span><\/span><\/h1>\n<h1 style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;margin-bottom: 0px;text-align: left;\"><span style=\"color: rgb(136, 136, 136);font-size: 15px;\"><span style=\"color: rgb(136, 136, 136);letter-spacing: 0.578px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\">https:\/\/www.forbes.com\/sites\/robtoews\/2023\/07\/16\/the-next-frontier-for-large-language-models-is-biology\/<\/span><\/span><\/h1>\n<\/section>\n<\/section>\n<\/blockquote>\n<article>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><time><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><\/span><\/time><\/section>\n<p style=\"text-align: center;\"><img class=\"rich_pages wxw-img\" data-height=\"1142\" data-ratio=\"0.6548488008342023\" data-type=\"jpeg\" data-w=\"959\" data-width=\"1744\" style=\"box-sizing: inherit;border-style: none;display: block;width: 396px;max-height: 100%;min-height: 100%;min-width: 100%;top: 0px;height: auto !important;\"  src=\"\/wp-content\/uploads\/2023\/08\/wxsync-2023-08-0470f4313f82f214926232159b859b06.jpeg\"  \/><span style=\"color: rgb(136, 136, 136);font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.034em;text-align: center;\">\u56fe\u7247\u6765\u6e90<\/span><span style=\"color: rgb(136, 136, 136);font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.034em;text-align: center;\">: U OF W, ROYAL SOCIETY, HARVARD<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;line-height: 1.75em;margin-bottom: 0px;\"><br  \/><\/p>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"color: rgb(63, 63, 63);font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 15px;letter-spacing: 0.034em;\">Large language models like GPT-4 have taken the world by storm thanks to their astonishing command of natural language. Yet the most significant long-term opportunity for LLMs will entail an entirely different type of language: the language of biology.<\/span><br  \/><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">One striking theme has emerged from the long march of research progress across biochemistry, molecular biology and genetics over the past century: it turns out that biology is a decipherable, programmable, in some ways even&nbsp;digital&nbsp;system.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-1\" progressive=\"\" position=\"mobilerec\" display-called=\"\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">DNA encodes the complete genetic instructions for every living organism on earth using just four variables\u2014A (adenine), C (cytosine), G (guanine) and T (thymine). Compare this to modern computing systems, which use two variables\u20140 and 1\u2014to encode all the world\u2019s digital electronic information. One system is binary and the other is&nbsp;quaternary, but the two have a surprising amount of conceptual overlap; both systems can properly be thought of as digital.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">To take another example, every protein in every living being consists of and is defined by a one-dimensional string of amino acids linked together in a particular order. Proteins range from a few dozen to several thousand amino acids in length, with 20 different amino acids to choose from.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-2\" progressive=\"\" position=\"mobilex\" display-called=\"\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">This, too, represents an eminently computable system, one that language models are well-suited to learn.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">As DeepMind CEO\/cofounder Demis Hassabis put it: \u201cAt its most fundamental level, I think biology can be thought of as an information processing system, albeit an extraordinarily complex and dynamic one. Just as mathematics turned out to be the right description language for physics, biology may turn out to be the perfect type of regime for the application of AI.\u201d<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Large language models are at their most powerful when they can feast on vast volumes of signal-rich data, inferring latent patterns and deep structure that go well beyond the capacity of any human to absorb. They can then use this intricate understanding of the subject matter to generate novel, breathtakingly sophisticated output.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><cnx><cnx><\/cnx><cnx><cnx><cnx><cnx><cnx><\/cnx><\/cnx><cnx><cnx><cnx><cnx><cnx><cnx><\/cnx><cnx><cnx><cnx><cnx><cnx><\/cnx><\/cnx><\/cnx><\/cnx><\/cnx><\/cnx><\/cnx><cnx><cnx><cnx aria-expanded=\"false\" aria-haspopup=\"true\" aria-controls=\"cnx-ui-cm-settings\" aria-label=\"More\" role=\"button\" tabindex=\"0\"><cnx><\/cnx><\/cnx><\/cnx><cnx><cnx aria-label=\"Close Player\" role=\"button\" tabindex=\"0\"><cnx><\/cnx><\/cnx><\/cnx><\/cnx><\/cnx><\/cnx><cnx><cnx><cnx><cnx><cnx aria-label=\"Previous (Shift + P)\" role=\"button\" tabindex=\"0\"><cnx><\/cnx><\/cnx><\/cnx><cnx><cnx role=\"button\" tabindex=\"0\" aria-label=\"Play (SPACE)\" aria-hidden=\"false\"><cnx><cnx><\/cnx><\/cnx><\/cnx><\/cnx><cnx><cnx aria-label=\"Next (Shift + N)\" role=\"button\" tabindex=\"0\"><cnx><\/cnx><\/cnx><\/cnx><\/cnx><\/cnx><\/cnx><cnx><cnx><cnx><cnx role=\"button\" tabindex=\"0\" aria-label=\"Unmute (m)\"><cnx><\/cnx><\/cnx><\/cnx><\/cnx><\/cnx><cnx data-id=\"cnx-ui-cm-settings\"><cnx><cnx role=\"group\"><cnx tabindex=\"0\" role=\"button\" aria-label=\"About Connatix\"><\/cnx><\/cnx><\/cnx><\/cnx><\/cnx><cnx><cnx><cnx><cnx><cnx><\/cnx><\/cnx><\/cnx><\/cnx><cnx><cnx><cnx><cnx><\/cnx><\/cnx><cnx><\/cnx><\/cnx><\/cnx><cnx><cnx><cnx><cnx><\/cnx><\/cnx><\/cnx><\/cnx><cnx><cnx><cnx><cnx><\/cnx><\/cnx><\/cnx><\/cnx><cnx><cnx><\/cnx><\/cnx><cnx><cnx><\/cnx><\/cnx><cnx><cnx><\/cnx><\/cnx><cnx><cnx><\/cnx><\/cnx><cnx><cnx><\/cnx><\/cnx><cnx><cnx><\/cnx><\/cnx><cnx><cnx><cnx><cnx><\/cnx><\/cnx><\/cnx><\/cnx><cnx><cnx><cnx><cnx><\/cnx><\/cnx><\/cnx><\/cnx><\/cnx><\/cnx><cnx><cnx><cnx title=\"https:\/\/www.forbes.com\/sites\/gordonkelly\/2023\/07\/16\/apple-iphone-15-pro-max-design-colors-finishes-new-iphone-release\/?traffic_source=Connatix\"><\/cnx><\/cnx><\/cnx><\/cnx><\/cnx><cnx><\/cnx><\/cnx><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">By ingesting all of the text on the internet, for instance, tools like ChatGPT have learned to converse with thoughtfulness and nuance on any imaginable topic. By ingesting billions of images, text-to-image models like Midjourney have learned to produce creative original imagery on demand.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Pointing large language models at biological data\u2014enabling them to learn&nbsp;the language of life\u2014will unlock possibilities that will make natural language and images seem almost trivial by comparison.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-3\" progressive=\"\" position=\"mobilex\" display-called=\"\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">What, concretely, will this look like?<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">In the near term, the most compelling opportunity to apply large language models in the life sciences is to design novel proteins.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><br  \/><\/span><\/section>\n<h3 style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(63, 63, 63);\"><strong><span style=\"color: rgb(63, 63, 63);font-size: 15px;\">Proteins 101<\/span><\/strong><\/span><\/h3>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Proteins are at the center of life itself. As prominent biologist Arthur Lesk&nbsp;put it, \u201cIn the drama of life at a molecular scale, proteins are where the action is.\u201d<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Proteins are involved in virtually every important activity that happens inside every living thing: digesting food, contracting muscles, moving oxygen throughout the body, attacking foreign viruses. Your hormones are made out of proteins; so is your hair.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"brandvoice-inline-0\" position=\"ntv-article\" data-dynamic=\"true\" progressive=\"true\" display-called=\"\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Proteins are so important because they are so versatile. They are able to undertake a vast array of different structures and functions, far more than any other type of biomolecule. This incredible versatility is a direct consequence of how proteins are built.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">As mentioned above, every protein consists of a string of building blocks known as amino acids strung together in a particular order. Based on this one-dimensional amino acid sequence, proteins fold into complex three-dimensional shapes that enable them to carry out their biological functions.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-4\" progressive=\"\" position=\"mobilex\" display-called=\"\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">A protein\u2019s shape relates closely to its function. To take one example, antibody proteins fold into shapes that enable them to precisely identify and target foreign bodies, like a&nbsp;key fitting into a lock. As another example, enzymes\u2014proteins that speed up biochemical reactions\u2014are specifically shaped to bind with particular molecules and thus catalyze particular reactions. Understanding the shapes that proteins fold into is thus essential to understanding how organisms function, and ultimately how life itself works.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Determining a protein\u2019s three-dimensional structure based solely on its one-dimensional amino acid sequence has stood as a grand challenge in the field of biology for over half a century. Referred to as the \u201cprotein folding problem,\u201d it has stumped generations of scientists. One commentator in 2007&nbsp;described&nbsp;the protein folding problem as \u201cone of the most important yet unsolved issues of modern science.\u201d<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><br  \/><\/section>\n<h3 style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Deep Learning And Proteins: A Match Made In Heaven<\/span><\/strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><\/span><\/h3>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">In late 2020, in&nbsp;a watershed moment&nbsp;in both biology and computing, an AI system called AlphaFold produced a solution to the protein folding problem. Built by Alphabet\u2019s DeepMind, AlphaFold correctly predicted proteins\u2019 three-dimensional shapes to within the width of about one atom, far outperforming any other method that humans had ever devised.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-5\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">It is hard to overstate AlphaFold\u2019s significance. Long-time protein folding expert John Moult&nbsp;summed it upwell: \u201cThis is the first time a serious scientific problem has been solved by AI.\u201d<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Yet when it comes to AI and proteins, AlphaFold was just the beginning.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">AlphaFold was not built using large language models. It relies on an older bioinformatics construct called multiple sequence alignment (MSA), in which a protein\u2019s sequence is compared to evolutionarily similar proteins in order to deduce its structure.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-6\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">MSA can be powerful, as AlphaFold made clear, but it has limitations.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">For one, it is slow and compute-intensive because it needs to reference many different protein sequences in order to determine any one protein\u2019s structure. More importantly, because MSA requires the existence of numerous evolutionarily and structurally similar proteins in order to reason about a new protein sequence, it is of limited use for so-called&nbsp;\u201corphan proteins\u201d\u2014proteins with few or no close analogues. Such orphan proteins represent roughly 20% of all known protein sequences.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Recently, researchers have begun to explore an intriguing alternative approach: using large language models, rather than multiple sequence alignment, to predict protein structures.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u201cProtein language models\u201d\u2014LLMs trained not on English words but rather on protein sequences\u2014have demonstrated an astonishing ability to intuit the complex patterns and interrelationships between protein sequence, structure and function: say, how changing certain amino acids in certain parts of a protein\u2019s sequence will affect the shape that the protein folds into. Protein language models are able to, if you will, learn the grammar or&nbsp;linguistics of proteins.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-7\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">The idea of a protein language model dates back to the 2019&nbsp;UniRep work&nbsp;out of George Church\u2019s lab at Harvard (though UniRep used LSTMs rather than today\u2019s state-of-the-art transformer models).<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">In late 2022, Meta&nbsp;debuted&nbsp;ESM-2 and ESMFold, one of the largest and most sophisticated protein language models published to date, weighing in at 15 billion parameters. (ESM-2 is the LLM itself; ESMFold is its associated structure prediction tool.)<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-8\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">ESM-2\/ESMFold is about as accurate as AlphaFold at predicting proteins\u2019 three-dimensional structures. But unlike AlphaFold, it is able to generate a structure based on a single protein sequence, without requiring any structural information as input. As a result, it is up to 60 times faster than AlphaFold. When researchers are looking to screen millions of protein sequences at once in a protein engineering workflow, this speed advantage makes a huge difference. ESMFold can also produce more accurate structure predictions than AlphaFold for orphan proteins that lack evolutionarily similar analogues.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Language models\u2019 ability to develop a generalized understanding of the&nbsp;\u201clatent space\u201d&nbsp;of proteins opens up exciting possibilities in protein science.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-9\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">But an even more powerful conceptual advance has taken place in the years since AlphaFold.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">In short, these protein models can be inverted: rather than predicting a protein\u2019s structure based on its sequence, models like ESM-2&nbsp;can be reversed&nbsp;and used to&nbsp;generate totally novel protein sequences&nbsp;that do not exist in nature based on desired properties.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><br  \/><\/section>\n<h3 style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Inventing New Proteins<\/span><\/strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><\/span><\/h3>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-10\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">All the proteins that exist in the world today represent but an infinitesimally tiny fraction of all the proteins that could theoretically exist. Herein lies the opportunity.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">To give some rough numbers: the total set of proteins that exist in the human body\u2014the so-called \u201chuman proteome\u201d\u2014is&nbsp;estimated&nbsp;to number somewhere between 80,000 and 400,000 proteins. Meanwhile, the number of proteins that could theoretically exist is&nbsp;in the neighborhood of&nbsp;10<span style=\"font-size:12px;\"><sup>1300<\/sup><\/span>\u2014an unfathomably large number, many times greater than the number of atoms in the universe. (To be clear, not all of these 10<span style=\"font-size:12px;\"><sup>1300<\/sup><\/span> possible amino acid combinations would result in biologically viable proteins. Far from it. But some subset would.)<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Over many millions of years, the meandering process of evolution has stumbled upon tens or hundreds of thousands of these viable combinations. But this is merely the tip of the iceberg.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">In the words of&nbsp;Molly Gibson, cofounder of leading protein AI startup Generate Biomedicines: \u201cThe amount of sequence space that nature has sampled through the history of life would equate to almost just a drop of water in all of Earth\u2019s oceans.\u201d<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-11\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">An opportunity exists for us to improve upon nature. After all, as powerful of a force as it is, evolution by natural selection is not all-seeing; it does not plan ahead; it does not reason or optimize in top-down fashion. It unfolds randomly and opportunistically, propagating combinations that happen to work.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Using AI, we can for the first time&nbsp;systematically and comprehensively&nbsp;explore the vast uncharted realms of protein space in order to design proteins unlike anything that has ever existed in nature, purpose-built for our medical and commercial needs.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-12\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">We will be able to design new protein therapeutics to address the full gamut of human illness\u2014from cancer to autoimmune diseases, from diabetes to neurodegenerative disorders. Looking beyond medicine, we will be able to create new classes of proteins with transformative applications in agriculture, industrials, materials science, environmental remediation and beyond.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Some early efforts to use deep learning for de novo protein design have not made use of large language models.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">One prominent example is&nbsp;ProteinMPNN, which came out of David Baker\u2019s world-renowned lab at the University of Washington. Rather than using LLMs, the ProteinMPNN architecture relies heavily on protein structure data in order to generate novel proteins.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-13\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">The Baker lab more recently published&nbsp;RFdiffusion, a more advanced and generalized protein design model. As its name suggests, RFdiffusion is built using diffusion models, the same AI technique that powers text-to-image models like Midjourney and Stable Diffusion. RFdiffusion can generate novel, customizable protein \u201cbackbones\u201d\u2014that is, proteins\u2019 overall structural scaffoldings\u2014onto which sequences can then be layered.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Structure-focused models like ProteinMPNN and RFdiffusion are impressive achievements that have advanced the state of the art in AI-based protein design. Yet we may be on the cusp of a new step-change in the field, thanks to the transformative capabilities of large language models.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-14\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Why are language models such a promising path forward compared to other computational approaches to protein design? One key reason: scaling.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><br  \/><\/section>\n<h3 style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Scaling Laws<\/span><\/strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><\/span><\/h3>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">One of the key forces behind the dramatic recent progress in artificial intelligence is so-called&nbsp;\u201cscaling laws\u201d: the fact that almost unbelievable improvements in performance result from continued increases in LLM parameter count, training data and compute.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-15\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">At each order-of-magnitude increase in scale, language models have demonstrated remarkable, unexpected, emergent new capabilities that transcend what was possible at smaller scales.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">It is OpenAI\u2019s commitment to the principle of scaling, more than anything else, that has catapulted the organization to the forefront of the field of artificial intelligence in recent years. As they moved from GPT-2 to GPT-3 to GPT-4 and beyond, OpenAI has built larger models, deployed more compute and trained on larger datasets than any other group in the world, unlocking stunning and unprecedented AI capabilities.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">How are scaling laws relevant in the realm of proteins?<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Thanks to scientific breakthroughs that have made gene sequencing vastly cheaper and more accessible over the past two decades, the amount of DNA and thus protein sequence data available to train AI models is growing exponentially, far outpacing protein structure data.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-16\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Protein sequence data can be tokenized and for all intents and purposes treated as textual data; after all, it consists of linear strings of amino acids in a certain order, like words in a sentence. Large language models can be trained solely on protein sequences to develop a nuanced understanding of protein structure and biology.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">This domain is thus ripe for massive scaling efforts powered by LLMs\u2014efforts that may result in astonishing emergent insights and capabilities in protein science.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">The first work to use transformer-based LLMs to design de novo proteins was&nbsp;ProGen, published by Salesforce Research in 2020. The original ProGen model was 1.2 billion parameters.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-17\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Ali Madani, the lead researcher on ProGen, has since founded a startup named Profluent Bio to advance and commercialize the state of the art in LLM-driven protein design.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">While he pioneered the use of LLMs for protein design, Madani is also clear-eyed about the fact that, by themselves, off-the-shelf language models trained on raw protein sequences are not the most powerful way to tackle this challenge. Incorporating structural and functional data is essential.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">\u201cThe greatest advances in protein design will be at the intersection of careful data curation from diverse sources and versatile modeling that can flexibly learn from that data,\u201d Madani said. \u201cThis entails making use of all high-signal data at our disposal\u2014including protein structures and functional information derived from the laboratory.\u201d<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-18\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Another intriguing early-stage startup applying LLMs to design novel protein therapeutics is Nabla Bio. Spun out of George Church\u2019s lab at Harvard and led by the team behind UniRep, Nabla is focused specifically on antibodies. Given that 60% of all protein therapeutics today are antibodies and that the&nbsp;two highest-selling drugs&nbsp;in the world are antibody therapeutics, it is hardly a surprising choice.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Nabla has decided not to develop its own therapeutics but rather to offer its cutting-edge technology to biopharma partners as a tool to help them develop their own drugs.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Expect to see much more startup activity in this area in the months and years ahead as the world wakes up to the fact that protein design represents a massive and still underexplored field to which to apply large language models\u2019 seemingly magical capabilities.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-19\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><br  \/><\/section>\n<h3 style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">The Road Ahead<\/span><\/strong><span style=\"font-size: 15px;color: rgb(63, 63, 63);\"><\/span><\/h3>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">In her acceptance speech for the 2018 Nobel Prize in Chemistry, Frances Arnold&nbsp;said: \u201cToday we can for all practical purposes read, write, and edit any sequence of DNA, but we cannot&nbsp;compose&nbsp;it. The code of life is a symphony, guiding intricate and beautiful parts performed by an untold number of players and instruments. Maybe we can cut and paste pieces from nature\u2019s compositions, but we do not know how to write the bars for a single enzymic passage.\u201d<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-20\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">As recently as five years ago, this was true.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">But AI may give us the ability, for the first time in the history of life, to actually&nbsp;compose&nbsp;entirely new proteins (and their associated genetic code) from scratch, purpose-built for our needs. It is an awe-inspiring possibility.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">These novel proteins will serve as therapeutics for a wide range of human illnesses, from infectious diseases to cancer; they will help make gene editing a reality; they will transform materials science; they will improve agricultural yields; they will neutralize pollutants in the environment; and so much more that we cannot yet even imagine.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-21\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">The field of AI-powered\u2014and especially LLM-powered\u2014protein design is still nascent and unproven. Meaningful scientific, engineering, clinical and business obstacles remain. Bringing these new therapeutics and products to market will take years.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Yet over the long run, few market applications of AI hold greater promise.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">In future articles, we will delve deeper into LLMs for protein design, including exploring the most compelling commercial applications for the technology as well as the complicated relationship between computational outcomes and real-world wet lab experiments.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-22\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Let\u2019s end by zooming out. De novo protein design is not the only exciting opportunity for large language models in the life sciences.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Language models can be used to generate other classes of biomolecules, notably nucleic acids. A buzzy startup named Inceptive, for example, is applying LLMs to generate novel RNA therapeutics.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Other groups have even broader aspirations, aiming to build generalized \u201cfoundation models for biology\u201d that can fuse diverse data types spanning genomics, protein sequences, cellular structures, epigenetic states, cell images, mass spectrometry, spatial transcriptomics and beyond.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-23\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">The ultimate goal is to move beyond modeling an individual molecule like a protein to modeling proteins\u2019 interactions with other molecules, then to modeling whole cells, then tissues, then organs\u2014and eventually entire organisms.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">The idea of building an artificial intelligence system that can understand and&nbsp;design&nbsp;every intricate detail of a complex biological system is mind-boggling. In time, this will be within our grasp.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><fbs-ad ad-id=\"inline-article-0-ad-24\" progressive=\"\" position=\"mobilex\"><\/fbs-ad><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">The twentieth century was defined by fundamental advances in physics: from Albert Einstein\u2019s theory of relativity to the discovery of quantum mechanics, from the nuclear bomb to the transistor. As many modern observers have noted, the twenty-first century is shaping up to be the century of biology. Artificial intelligence and large language models will play a central role in unlocking biology\u2019s secrets and unleashing its possibilities in the decades ahead.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(63, 63, 63);\">Buckle up.<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><br  \/><\/section>\n<section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;text-align: center;\"><img class=\"rich_pages wxw-img\" data-ratio=\"1.2527777777777778\" data-type=\"jpg\" data-w=\"1080\" style=\"width: 329px;height: auto !important;\"  src=\"\/wp-content\/uploads\/2023\/08\/wxsync-2023-08-bd35f184246c2e797cff1d0c61e4e023.jpg\"  \/><\/section>\n<\/section>\n<section style=\"margin-right: 8px;margin-bottom: 24px;margin-left: 8px;line-height: 1.75em;\"><br  \/><\/section>\n<\/article>\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);text-align: center;justify-content: center;\">\n<section style=\"outline: 0px;display: inline-block;width: auto;vertical-align: top;min-width: 10%;height: auto;box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-bottom: 9px solid rgb(169, 215, 227);border-bottom-right-radius: 0px;\">\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: -15px;outline: 0px;\">\n<section style=\"padding-right: 10px;padding-left: 10px;outline: 0px;color: rgb(12, 130, 169);font-size: 16px;line-height: 2;letter-spacing: 3px;\">\n<p style=\"outline: 0px;\"><strong style=\"outline: 0px;\">\u5927\u6a21\u578b\u4e0e\u751f\u547d\u533b\u5b66\uff1aAI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a\u542f\u52a8<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);\">\n<p style=\"outline: 0px;\"><br style=\"outline: 0px;color: rgb(63, 63, 63);font-family: PingFangSC-light;font-size: 15px;letter-spacing: 0.544px;\"  \/><\/p>\n<\/section>\n<section dir=\"ltr\" style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;letter-spacing: 0.544px;white-space: normal;clear: both;min-height: 1em;color: rgb(136, 136, 136);font-size: 14px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);line-height: 2em;\"><span style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 15px;letter-spacing: 0.544px;text-indent: 0em;\">\u751f\u7269\u533b\u5b66\u662f\u4e00\u4e2a\u590d\u6742\u4e14\u5bcc\u6709\u6311\u6218\u6027\u7684\u9886\u57df\uff0c\u6d89\u53ca\u5230\u5927\u91cf\u7684\u6570\u636e\u5904\u7406\u3001\u6a21\u5f0f\u8bc6\u522b\u3001\u7406\u8bba\u6a21\u578b\u5efa\u6784\u548c\u5b9e\u9a8c\u9a8c\u8bc1\u7b49\u95ee\u9898\u3002AI\u57fa\u7840\u6a21\u578b\u7684\u5f15\u5165\uff0c\u4f7f\u5f97\u6211\u4eec\u80fd\u591f\u4ece\u524d\u6240\u672a\u6709\u7684\u89d2\u5ea6\u53bb\u89c2\u5bdf\u548c\u7406\u89e3\u8fd9\u4e2a\u9886\u57df\u7684\u95ee\u9898\uff0c\u52a0\u901f\u79d1\u5b66\u7814\u7a76\u7684\u6b65\u4f10\uff0c\u63d0\u9ad8\u533b\u7597\u670d\u52a1\u7684\u6548\u7387\u548c\u6548\u679c\u3002\u8fd9\u79cd\u4ea4\u53c9\u9886\u57df\u7684\u5408\u4f5c\uff0c\u6807\u5fd7\u7740\u6211\u4eec\u6b63\u5728\u5411\u79d1\u6280\u4e0e\u751f\u7269\u533b\u5b66\u6df1\u5ea6\u878d\u5408\u7684\u65b0\u65f6\u4ee3\u8fc8\u8fdb\uff0c\u5bf9\u4e8e\u63a8\u52a8\u79d1\u5b66\u7814\u7a76\u3001\u4f18\u5316\u533b\u7597\u670d\u52a1\u3001\u4fc3\u8fdb\u4eba\u7c7b\u5065\u5eb7\u6709\u7740\u6df1\u8fdc\u7684\u5f71\u54cd\u3002<\/span><\/section>\n<section dir=\"ltr\" style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;font-family: system-ui, -apple-system, &quot;system-ui&quot;, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-wrap: wrap;background-color: rgb(255, 255, 255);line-height: 1.75em;\"><br  \/><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;letter-spacing: 0.544px;white-space: normal;clear: both;min-height: 1em;color: rgb(136, 136, 136);font-size: 14px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);line-height: 2em;\"><span style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 15px;letter-spacing: 0.544px;text-indent: 0em;\">\u96c6\u667a\u4ff1\u4e50\u90e8\u8054\u5408\u897f\u6e56\u5927\u5b66\u52a9\u7406\u6559\u6388\u5434\u6cf0\u9716\u3001\u65af\u5766\u798f\u5927\u5b66\u8ba1\u7b97\u673a\u79d1\u5b66\u7cfb\u535a\u58eb\u540e\u7814\u7a76\u5458\u738b\u701a\u5bb8\u3001\u535a\u58eb\u7814\u7a76\u751f\u9ec4\u67ef\u946b\u3001\u9ec4\u5029\uff0c\u534e\u76db\u987f\u5927\u5b66\u535a\u58eb\u7814\u7a76\u751f\u5c60\u946b\u660e\uff0c\u5171\u540c\u53d1\u8d77\u4ee5\u201c\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\u201d\u4e3a\u4e3b\u9898\u7684\u8bfb\u4e66\u4f1a\uff0c<span style=\"color: rgb(136, 136, 136);font-size: 15px;letter-spacing: 0.544px;text-wrap: wrap;background-color: rgb(255, 255, 255);\">\u5171\u5b66\u5171\u7814\u76f8\u5173\u6587\u732e\uff0c<\/span><\/span><span style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 15px;letter-spacing: 0.544px;text-indent: 0em;\">\u63a2\u8ba8\u57fa\u7840\u6a21\u578b\u5728\u751f\u7269\u533b\u5b66\u7b49\u79d1\u5b66\u9886\u57df\u7684\u5e94\u7528\u3001\u5f71\u54cd\u548c\u5c55\u671b\u3002<\/span><span style=\"letter-spacing: 0.544px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 15px;text-indent: 0em;\">\u8bfb\u4e66\u4f1a\u4ece2023\u5e748\u670813\u65e5\u5f00\u59cb\uff0c\u6bcf\u5468\u65e5\u65e9\u4e0a 9:00-11:00 \u7ebf\u4e0a\u4e3e\u884c\uff0c\u6301\u7eed\u65f6\u95f4\u9884\u8ba18\u5468\u3002<\/span><span style=\"letter-spacing: 0.544px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 15px;text-indent: 0em;\">\u6b22\u8fce\u5bf9\u63a2\u7d22\u8fd9\u4e2a\u6fc0\u52a8\u4eba\u5fc3\u7684\u524d\u6cbf\u9886\u57df\u6709\u5174\u8da3\u7684\u670b\u53cb\u62a5\u540d\u53c2\u4e0e\u3002<\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;letter-spacing: 0.544px;white-space: normal;clear: both;min-height: 1em;color: rgb(136, 136, 136);font-size: 14px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);line-height: 2em;\"><span style=\"outline: 0px;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 15px;letter-spacing: 0.544px;text-indent: 0em;\"><br style=\"outline: 0px;\"  \/><\/span><\/section>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;font-family: system-ui, -apple-system, &quot;system-ui&quot;, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;white-space: normal;background-color: rgb(255, 255, 255);letter-spacing: 0.578px;text-align: center;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247669471&amp;idx=1&amp;sn=4e34c8c0225bf146c5977a0320140929&amp;chksm=e8990c52dfee8544b79768e22456277f7440648b1b879e192a13b441266354228c6340fe7afd&amp;scene=21#wechat_redirect\" textvalue=\"\u4f60\u5df2\u9009\u4e2d\u4e86\u6dfb\u52a0\u94fe\u63a5\u7684\u5185\u5bb9\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"1\" hasload=\"1\" class=\"wx_tap_link\" rel=\"noopener noreferrer\"><span class=\"js_jump_icon h5_image_link\" style=\"outline: 0px;vertical-align: bottom;user-select: none;\"><img class=\"rich_pages wxw-img\" data-backh=\"315\" data-backw=\"562\" data-ratio=\"0.5611111111111111\" data-w=\"1080\" style=\"outline: 0px;border: 0px;width: 661px;visibility: visible !important;height: auto !important;\"  src=\"\/wp-content\/uploads\/2023\/08\/wxsync-2023-08-4663c4d04a67e1800f3df1c260afd7fe.png\"  \/><\/span><\/a><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;font-family: system-ui, -apple-system, &quot;system-ui&quot;, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;white-space: normal;background-color: rgb(255, 255, 255);letter-spacing: 0.578px;text-align: center;\"><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);line-height: 2em;\"><span style=\"outline: 0px;font-size: 15px;letter-spacing: 0.544px;text-indent: 0em;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><span style=\"outline: 0px;color: rgb(63, 63, 63);font-family: system-ui, -apple-system, &quot;system-ui&quot;, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;\">\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);line-height: 2em;\"><span style=\"outline: 0px;text-indent: 0em;color: rgb(63, 63, 63);font-family: system-ui, -apple-system, &quot;system-ui&quot;, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 15px;letter-spacing: 0.544px;text-decoration: underline;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247669471&amp;idx=1&amp;sn=4e34c8c0225bf146c5977a0320140929&amp;chksm=e8990c52dfee8544b79768e22456277f7440648b1b879e192a13b441266354228c6340fe7afd&amp;scene=21#wechat_redirect\" textvalue=\"\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1aAI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a\u542f\u52a8\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;\" rel=\"noopener noreferrer\">\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1aAI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a\u542f\u52a8<\/a><\/span><span style=\"outline: 0px;text-indent: 0em;color: rgb(63, 63, 63);font-family: system-ui, -apple-system, &quot;system-ui&quot;, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 15px;letter-spacing: 0.544px;\"><br style=\"outline: 0px;\"  \/><\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;font-family: system-ui, -apple-system, &quot;system-ui&quot;, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 2em;\"><br  \/><\/p>\n<section style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;font-family: system-ui, -apple-system, &quot;system-ui&quot;, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);\"><br  \/><\/section>\n<p style=\"margin-right: 8px;margin-bottom: 5px;margin-left: 8px;outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;white-space: normal;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;color: rgb(0, 0, 0);font-size: 16px;text-align: center;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;\"><strong style=\"outline: 0px;text-align: left;color: rgb(33, 166, 210);font-family: PingFangSC-light;letter-spacing: 0.544px;\"><span style=\"outline: 0px;font-size: 15px;letter-spacing: 0.544px;\">\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n<section style=\"margin-right: 8px;margin-bottom: 8px;margin-left: 8px;outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;white-space: normal;\"><strong style=\"outline: 0px;\"><span style=\"display: none;line-height: 0px;\">\u200d<\/span>1.&nbsp;<\/strong><span style=\"text-decoration: underline;\"><strong style=\"outline: 0px;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247661929&amp;idx=1&amp;sn=de9f5d1f70ca63fbad3e8ce68ee14a87&amp;chksm=e89923e4dfeeaaf2b8cbe1bbb230bdf997e360fe63d0c42f9523d0bb2c395c5f1dedbf232402&amp;scene=21#wechat_redirect\" textvalue=\"Science\u524d\u6cbf\uff1a\u5927\u8bed\u8a00\u6a21\u578b\u6d8c\u73b0\u6f14\u5316\u4fe1\u606f\uff0c\u52a0\u901f\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener noreferrer\">Science\u524d\u6cbf\uff1a\u5927\u8bed\u8a00\u6a21\u578b\u6d8c\u73b0\u6f14\u5316\u4fe1\u606f\uff0c\u52a0\u901f\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b<\/a><\/strong><\/span><strong style=\"outline: 0px;\"><\/strong><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 8px;margin-left: 8px;outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;white-space: normal;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\">2.<\/strong><span style=\"text-decoration: underline;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\">&nbsp;<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247668611&amp;idx=1&amp;sn=04469c8119080bf7c17ba51d34470e90&amp;chksm=e899090edfee8018498820ddfafb7761c9a277ede61f015ef24bfbba524ae0a3a0e2ce9501f8&amp;scene=21#wechat_redirect\" textvalue=\"14\u4e2a\u673a\u678463\u4f4d\u5b66\u8005\u5408\u4f5c AI for Science \u91cd\u78c5\u7efc\u8ff0\uff1a\u7528\u4e8e\u91cf\u5b50\u3001\u539f\u5b50\u548c\u8fde\u7eed\u4f53\u7cfb\u79d1\u5b66\u7684\u4eba\u5de5\u667a\u80fd\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener noreferrer\">14\u4e2a\u673a\u678463\u4f4d\u5b66\u8005\u5408\u4f5c AI for Science \u91cd\u78c5\u7efc\u8ff0\uff1a\u7528\u4e8e\u91cf\u5b50\u3001\u539f\u5b50\u548c\u8fde\u7eed\u4f53\u7cfb\u79d1\u5b66\u7684\u4eba\u5de5\u667a\u80fd<\/a><\/strong><\/span><strong style=\"outline: 0px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"><\/strong><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 8px;margin-left: 8px;outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;white-space: normal;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\">3.&nbsp;<\/strong><\/strong><span style=\"text-decoration: underline;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247659365&amp;idx=1&amp;sn=d90cd2b209b6da9eefeb32b7e450e4ba&amp;chksm=e89935e8dfeebcfe7f8fdfd9d1192a54004a95c48c8e94d37d17b3718dad647ec3862a6e58ea&amp;scene=21#wechat_redirect\" textvalue=\"AI\u4f55\u4ee5\u6d8c\u73b0\uff1a\u590d\u6742\u9002\u5e94\u7cfb\u7edf\u89c6\u89d2\u7684ChatGPT\u548c\u5927\u8bed\u8a00\u6a21\u578b\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener noreferrer\">AI\u4f55\u4ee5\u6d8c\u73b0\uff1a\u590d\u6742\u9002\u5e94\u7cfb\u7edf\u89c6\u89d2\u7684ChatGPT\u548c\u5927\u8bed\u8a00\u6a21\u578b<\/a><\/strong><\/strong><\/span><strong style=\"outline: 0px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><\/strong><\/strong><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 8px;margin-left: 8px;outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;white-space: normal;\"><strong style=\"letter-spacing: 0.544px;outline: 0px;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><\/strong><\/strong><\/strong><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 8px;margin-left: 8px;outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;white-space: normal;\"><span style=\"outline: 0px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><strong style=\"color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;text-wrap: wrap;outline: 0px;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\">4.&nbsp;<\/strong><\/strong><span style=\"color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;text-wrap: wrap;text-decoration: underline;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247662658&amp;idx=1&amp;sn=90142fbe669a1b4081c54a6c7e288931&amp;chksm=e89926cfdfeeafd9c84b46276f593de259ef441d8531e02000abb98347bac17fd81925eb6620&amp;scene=21#wechat_redirect\" textvalue=\"\u5982\u4f55\u53d1\u73b0 AI+Science \u4e2d\u7684\u4e0b\u4e00\u4e2a AlphaFold \u548c ChatGPT\uff1f\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener noreferrer\">\u5982\u4f55\u53d1\u73b0 AI+Science \u4e2d\u7684\u4e0b\u4e00\u4e2a AlphaFold \u548c ChatGPT\uff1f<\/a><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 8px;margin-left: 8px;outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;white-space: normal;\"><span style=\"outline: 0px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><strong style=\"color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;text-wrap: wrap;outline: 0px;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\">5.&nbsp;<\/strong><\/strong><span style=\"color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;text-wrap: wrap;text-decoration: underline;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247636567&amp;idx=1&amp;sn=7636cf32eb02806899d72dae59c205ae&amp;chksm=e8998cdadfee05cc1b675e608991316fd57b101d9e2817fe99cea8b8a4b4b51ca76e55f1b79a&amp;scene=21#wechat_redirect\" textvalue=\"2\u4ebf\u4e2aAlphaFold\u9884\u6d4b\u7ed3\u6784\u4e2d\u9690\u85cf\u7684\u86cb\u767d\u8d28\u8fdb\u5316\u8d8b\u52bf | \u96c6\u667a\u79d1\u5b66\u5bb6\u6700\u65b0\u6210\u679c\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener noreferrer\">2\u4ebf\u4e2aAlphaFold\u9884\u6d4b\u7ed3\u6784\u4e2d\u9690\u85cf\u7684\u86cb\u767d\u8d28\u8fdb\u5316\u8d8b\u52bf | \u96c6\u667a\u79d1\u5b66\u5bb6\u6700\u65b0\u6210\u679c<\/a><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 8px;margin-left: 8px;outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;white-space: normal;\"><span style=\"outline: 0px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\">6.&nbsp;<\/strong><\/strong><\/span><span style=\"outline: 0px;text-decoration: underline;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247667315&amp;idx=1&amp;sn=fca3a09806e753fa83d3fd6eb8ccf9d8&amp;chksm=e89914fedfee9de82ae7107592b173d2a1c35141fab0006d3eac2dcb2dd1e74aa78a86e09a93&amp;scene=21#wechat_redirect\" textvalue=\"\u5f20\u6c5f\uff1a\u7b2c\u4e09\u4ee3\u4eba\u5de5\u667a\u80fd\u6280\u672f\u57fa\u7840\u2014\u2014\u4ece\u53ef\u5fae\u5206\u7f16\u7a0b\u5230\u56e0\u679c\u63a8\u7406 | \u96c6\u667a\u5b66\u56ed\u5168\u65b0\u8bfe\u7a0b\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;\" rel=\"noopener noreferrer\">\u5f20\u6c5f\uff1a\u7b2c\u4e09\u4ee3\u4eba\u5de5\u667a\u80fd\u6280\u672f\u57fa\u7840\u2014\u2014\u4ece\u53ef\u5fae\u5206\u7f16\u7a0b\u5230\u56e0\u679c\u63a8\u7406 | \u96c6\u667a\u5b66\u56ed\u5168\u65b0\u8bfe\u7a0b<\/a><\/strong><\/strong><\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 8px;margin-left: 8px;outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;white-space: normal;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\">7.&nbsp;<a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247576923&amp;idx=2&amp;sn=57f0d320812c01ff6f5ea97c09fc9623&amp;chksm=e896f7d6dfe17ec038e8d238dae313119fca8c62aabd4730896bc99398db981dd5d9d3e0b927&amp;scene=21#wechat_redirect\" textvalue=\"\u300a\u5f20\u6c5f\u00b7\u590d\u6742\u79d1\u5b66\u524d\u6cbf27\u8bb2\u300b\u5b8c\u6574\u4e0a\u7ebf\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"outline: 0px;color: var(--weui-LINK);text-decoration: underline;cursor: pointer;letter-spacing: 0.544px;\" rel=\"noopener noreferrer\"><strong style=\"outline: 0px;\">\u300a\u5f20\u6c5f\u00b7\u590d\u6742\u79d1\u5b66\u524d\u6cbf27\u8bb2\u300b\u5b8c\u6574\u4e0a\u7ebf\uff01<\/strong><\/a><\/strong><\/strong><\/strong><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 8px;margin-left: 8px;outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;white-space: normal;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\">8.&nbsp;<\/strong><\/strong><span style=\"outline: 0px;text-decoration: underline;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247668040&amp;idx=1&amp;sn=f8affd4855e022adad4431f8e5aed5a6&amp;chksm=e8990bc5dfee82d3eb44e56d0284df74e0b8a1c213db26e84a38a4b82606ed7309a046afbdd6&amp;scene=21#wechat_redirect\" textvalue=\"\u52a0\u5165\u96c6\u667a\u5b66\u56edVIP\uff0c\u83b7\u5f9720\u5468\u5e74\u201c\u6d8c\u73b0\u201d\u5b66\u672f\u5e74\u4f1a\u5165\u573a\u5238\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;\" rel=\"noopener noreferrer\">\u52a0\u5165\u96c6\u667a\u5b66\u56edVIP\uff0c\u83b7\u5f9720\u5468\u5e74\u201c\u6d8c\u73b0\u201d\u5b66\u672f\u5e74\u4f1a\u5165\u573a\u5238\uff01<\/a><\/strong><\/strong><\/strong><\/strong><\/span><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 10px;margin-left: 8px;outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;white-space: normal;\"><strong style=\"outline: 0px;\">9.&nbsp;<\/strong><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247667297&amp;idx=2&amp;sn=988b7314df45d949e69e81257801fff2&amp;chksm=e89914ecdfee9dfac76f9245fb1fd0e5b25d567e20790fbdab671234588ad0e88e1acf205711&amp;scene=21#wechat_redirect\" textvalue=\"\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u200d\u590d\u6742\uff01\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" hasload=\"1\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;\" rel=\"noopener noreferrer\"><span style=\"outline: 0px;text-decoration: underline;\"><strong style=\"outline: 0px;\">\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/span><\/a><\/section>\n<section style=\"margin-right: 8px;margin-bottom: 8px;margin-left: 8px;outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;white-space: normal;\"><br  \/><\/section>\n<p style=\"margin-right: 8px;margin-bottom: 5px;margin-left: 8px;outline: 0px;\"><br  \/><\/p>\n<section style=\"outline: currentcolor none 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(136, 136, 136);font-size: 14px;background-color: rgb(255, 255, 255);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;margin-bottom: 0px;\"><strong style=\"outline: 0px;letter-spacing: 0.544px;font-size: 15px;text-align: left;color: rgb(255, 255, 255);font-family: PingFangSC-light;\"><span style=\"outline: 0px;background-color: rgb(12, 130, 169);\">\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<strong style=\"letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);outline: 0px;font-size: 15px;text-align: left;color: rgb(255, 255, 255);font-family: PingFangSC-light;\"><\/strong><strong style=\"outline: 0px;letter-spacing: 0.544px;white-space: normal;font-size: 15px;text-align: left;color: rgb(255, 255, 255);font-family: PingFangSC-light;\"><\/strong><\/span><\/strong><\/section>\n<p>\u200b<\/p>\n<p style=\"display: none;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5bfc\u8bed \u6b63\u5982\u8bb8\u591a\u73b0\u4ee3\u89c2\u5bdf\u5bb6\u6240\u6307\u51fa\u7684\uff0c21\u4e16\u7eaa\u662f\u751f\u7269\u5b66\u7684\u4e16\u7eaa\u3002\u8fc7\u53bb\u51e0\u5e74\uff0c\u4ee5AlphaFold\u4e3a\u4ee3\u8868\u7684\u4eba\u5de5\u667a\u80fd\u6280\u672f\u5df2\u7ecf\u6210\u4e3a\u7834\u89e3\u751f\u547d\u590d\u6742\u6027\u96be\u9898\u7684\u91cd\u8981\u5de5\u5177\uff0c\u800c\u65b0\u5174\u7684\u5927\u8bed\u8a00\u6a21\u578b\u6709\u671b\u4ece\u591a\u4e2a\u5c42\u6b21\u8fdb\u4e00\u6b65\u63d0\u5347\u751f\u547d\u79d1\u5b66\u7814\u7a76\u3002 \u7814\u7a76\u9886\u57df\uff1a\u5927\u578b\u8bed\u8a00\u6a21\u578b\uff0c\u4eba\u5de5\u667a\u80fd\uff0cAI for Science\uff0c\u86cb\u767d\u8d28\u8bbe\u8ba1\uff0c\u751f\u7269\u5b66\u57fa\u7840\u6a21\u578b Ro&#8230;<\/p>\n","protected":false},"author":0,"featured_media":44334,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/44339"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=44339"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/44339\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/44334"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=44339"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=44339"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=44339"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=44339"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}