{"id":44370,"date":"2023-08-05T18:15:09","date_gmt":"2023-08-05T10:15:09","guid":{"rendered":"https:\/\/swarma.org\/?p=44370"},"modified":"2023-08-05T18:15:09","modified_gmt":"2023-08-05T10:15:09","slug":"nat-commun-%e9%80%9f%e9%80%92%ef%bc%9a%e5%9f%ba%e4%ba%8e%e6%a8%a1%e5%9e%8b%e7%9a%84%e5%9b%a0%e6%9e%9c%e6%8e%a8%e7%90%86%e6%96%b9%e6%b3%95%e5%85%8b%e6%9c%8d%e5%90%8c%e6%ad%a5%e6%80%a7%e5%92%8c","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=44370","title":{"rendered":"Nat. Commun.\u901f\u9012\uff1a\u57fa\u4e8e\u6a21\u578b\u7684\u56e0\u679c\u63a8\u7406\u65b9\u6cd5\u514b\u670d\u540c\u6b65\u6027\u548c\u95f4\u63a5\u6548\u5e94\u5f0a\u7aef"},"content":{"rendered":"
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\u5173\u952e\u8bcd\uff1a\u56e0\u679c\u63a8\u7406\uff0c\u7cfb\u7edf\u9884\u6d4b\uff0c\u57fa\u4e8e\u6a21\u578b\u7684\u65b9\u6cd5\uff0c\u590d\u6742\u7f51\u7edc<\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/p>\n


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\u8bba\u6587\u6807\u9898\uff1a<\/span>A general model-based causal inference method overcomes the curse of synchrony and indirect effect<\/span><\/section>\n

\u8bba\u6587\u6765\u6e90\uff1aNature Communications<\/em><\/span><\/p>\n

\u6591\u56fe\u94fe\u63a5\uff1ahttps:\/\/pattern.swarma.org\/paper\/ede02798-2a75-11ee-a474-0242ac17000d<\/span><\/p>\n

\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41467-023-39983-4<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n


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\u65e0\u6a21\u578b\u63a8\u7406\u65b9\u6cd5<\/span>\uff08model-free inference methods\uff09<\/span>\uff0c\u5982\u683c\u5170\u6770\u56e0\u679c\uff0c\u56e0\u5176\u5728\u8bc6\u522b\u56e0\u679c\u5173\u7cfb\u65f6\u5177\u6709\u7075\u6d3b\u6027\u88ab\u5e7f\u6cdb\u4f7f\u7528\uff0c\u7136\u800c\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u96be\u4ee5\u533a\u5206\u540c\u6b65\u548c\u95f4\u63a5\u6548\u5e94\u4e0e\u76f4\u63a5\u56e0\u679c\u5173\u7cfb\uff0c\u4ece\u800c\u5bfc\u81f4\u9519\u8bef\u9884\u6d4b\u3002<\/span><\/section>\n
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\u4e3a\u514b\u670d\u8fd9\u4e00\u95ee\u9898\uff0c\u4eba\u4eec\u5f00\u53d1\u4e86\u57fa\u4e8e\u6a21\u578b\u7684\u63a8\u7406\u65b9\u6cd5<\/span>\uff08model-based inference methods\uff09<\/span>\uff0c\u7528\u7279\u5b9a\u7684\u673a\u5236\u6a21\u578b\u6d4b\u8bd5\u6570\u636e\u53ef\u91cd\u590d\u6027\uff0c\u4ece\u800c\u63a8\u65ad\u56e0\u679c\u5173\u7cfb\uff0c\u7136\u800c\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u53ea\u80fd\u5e94\u7528\u4e8e\u7279\u5b9a\u6a21\u578b\u63cf\u8ff0\u7684\u7cfb\u7edf\uff0c\u5927\u5927\u9650\u5236\u4e86\u5176\u9002\u7528\u6027\u3002<\/span><\/section>\n
\u6587\u7ae0\u9488\u5bf9\u8fd9\u4e00\u5c40\u9650\u6027\uff0c\u63d0\u51fa\u4e00\u79cd\u57fa\u4e8e\u6a21\u578b\u7684\u65b9\u6cd5\uff0c\u53ef\u4ee5\u63a8\u65ad\u51fa\u7531\u4e00\u822c\u5355\u8c03\u5e38\u5fae\u5206\u65b9\u7a0b<\/span>\uff08ordinary differential equation, ODE\uff09<\/span>\u6a21\u578b\u63cf\u8ff0\u7684\u591a\u4e2a\u7ec4\u4ef6\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4e3a\u8be5\u6a21\u578b\u91cd\u73b0\u65f6\u95f4\u5e8f\u5217\u6570\u636e\u63a8\u5bfc\u51fa\u4e86\u4e00\u4e2a\u6613\u4e8e\u6d4b\u8bd5\u7684\u6761\u4ef6\uff0c\u7ed3\u679c\u8868\u660e\u8be5\u6846\u67b6\u6210\u529f\u63a8\u65ad\u51fa\u591a\u79cd\u6a21\u578b\u7684\u7f51\u7edc\u7ed3\u6784\u3002<\/span><\/section>\n
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\u56fe1 \u63a8\u65ad\u8c03\u63a7\u7f51\u7edc\u7684\u6846\u67b6\u3002(a) \u6846\u67b6\u5e94\u7528\u65b9\u6cd5\uff1bb-f \u5e94\u7528\u4e3e\u4f8b\uff1a\uff08b\uff09Kim-Forger\u6a21\u578b\u3001\uff08c\uff09Frzilator\u3001\uff08d\uff094\u6001Goodwin\u632f\u8361\u5668\u3001\uff08e\uff09\u679c\u8747\u663c\u591c\u8282\u5f8b\u949f\u7684Goldbeter\u6a21\u578b\uff0c\u548c\uff08f\uff09\u7af9\u836a\u7684cAMP\u632f\u8361\u5668<\/span><\/p>\n

\u8be5\u56e2\u961f\u8fd8\u5efa\u7acb\u4e86\u4e00\u4e2a\u7528\u6237\u53cb\u597d\u578b\u8ba1\u7b97\u8f6f\u4ef6\u5305\u2014\u2014\u57fa\u4e8e\u4e00\u822cODE\u7684\u63a8\u65ad\uff08GOBI\uff09\uff0c\u5b83\u51e0\u4e4e\u9002\u7528\u4e8e\u4efb\u4f55\u7531ODE\u63cf\u8ff0\u7684\u5177\u6709\u6b63\u8d1f\u89c4\u5b9a\u7684\u5355\u8c03\u7cfb\u7edf\uff0c\u4e0e\u73b0\u6709\u7684\u65e0\u6a21\u578b\u63a8\u7406\u65b9\u6cd5\u4e0d\u540c\uff0cGOBI\u6210\u529f\u5728\u5206\u5b50\u548c\u79cd\u7fa4\u6c34\u5e73\u4e0a\u63a8\u65ad\u51fa\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u3001\u751f\u6001\u7cfb\u7edf\u4ee5\u53ca\u7a7a\u6c14\u6c61\u67d3\u5bfc\u81f4\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u800c\u76ee\u524d\u6d41\u884c\u7684\u65e0\u6a21\u578b\u63a8\u65ad\u65b9\u6cd5\u65e0\u6cd5\u505a\u5230\u3002<\/span><\/section>\n

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\u56fe2 \u4ece\u5b9e\u9a8c\u6570\u636e\u4e2d\u63a8\u65ad\u8c03\u63a7\u7f51\u7edc<\/span><\/section>\n
\u7531\u4e8eGOBI\u5177\u6709\u51c6\u786e\u6027\u548c\u5e7f\u6cdb\u7684\u9002\u7528\u6027\uff0c\u8fd9\u662f\u4ee5\u5f80\u7684\u65e0\u6a21\u578b\u6216\u57fa\u4e8e\u6a21\u578b\u7684\u63a8\u65ad\u65b9\u6cd5\u6240\u4e0d\u5177\u5907\u7684\uff0c\u56e0\u6b64\u8fd9\u79cd\u7cbe\u786e\u800c\u5e7f\u6cdb\u9002\u7528\u7684\u63a8\u65ad\u65b9\u6cd5\u662f\u7406\u89e3\u590d\u6742\u52a8\u529b\u7cfb\u7edf\u7684\u6709\u529b\u5de5\u5177\u3002<\/span><\/section>\n
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\u52a0\u5165\u56e0\u679c\u79d1\u5b66\u793e\u533a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u7531\u667a\u6e90\u793e\u533a\u3001\u96c6\u667a\u4ff1\u4e50\u90e8\u8054\u5408\u4e3e\u529e\u7684<\/span>\u56e0\u679c\u79d1\u5b66\u4e0eCausal AI\u8bfb\u4e66\u4f1a\u7b2c\u4e09\u5b63<\/a>\uff0c\u4e3b\u8981\u9762\u5411\u4e24\u7c7b\u4eba\u7fa4\uff1a\u5982\u679c\u4f60\u4ece\u4e8b\u8ba1\u7b97\u673a\u76f8\u5173\u65b9\u5411\u7814\u7a76\uff0c\u5e0c\u671b\u4e3a\u4e0d\u540c\u9886\u57df\u5f15\u5165\u65b0\u7684\u8ba1\u7b97\u65b9\u6cd5\uff0c\u901a\u8fc7\u5927\u6570\u636e\u3001\u65b0\u7b97\u6cd5\u5f97\u5230\u65b0\u6210\u679c\uff0c\u53ef\u4ee5\u901a\u8fc7\u8bfb\u4e66\u4f1a\u5404\u4e2a\u9886\u57df\u7684\u6838\u5fc3\u56e0\u679c\u95ee\u9898\u4ecb\u7ecd\u548c\u8bba\u6587\u63a8\u8350\u5feb\u901f\u5165\u624b\uff1b\u5982\u679c\u4f60\u4ece\u4e8b\u5176\u4ed6\u7406\u5de5\u79d1\u6216\u4eba\u6587\u793e\u79d1\u9886\u57df\u7814\u7a76\uff0c\u4e5f\u53ef\u4ee5\u901a\u8fc7\u6240\u5c5e\u9886\u57df\u7684\u56e0\u679c\u7814\u7a76\u7efc\u8ff0\u4ecb\u7ecd\u548c\u7814\u8ba8\u5df2\u6709\u5de5\u4f5c\u7684\u793a\u4f8b\u4ee3\u7801\uff0c\u5728\u81ea\u5df1\u7684\u7814\u7a76\u4e2d\u5feb\u901f\u5f00\u59cb\u5c1d\u8bd5\u90e8\u7f72\u7ed3\u5408\u56e0\u679c\u7684\u7b97\u6cd5\u3002\u8bfb\u4e66\u4f1a\u76f4\u64ad\u5df2\u7ed3\u675f\uff0c\u6b22\u8fce\u52a0\u5165\u56e0\u679c\u79d1\u5b66\u793e\u533a\uff0c\u56de\u770b\u7b2c\u4e09\u5b63\u76f4\u64ad\uff0c\u52a0\u5165\u8ba8\u8bba\u3002<\/span><\/section>\n


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\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/p>\n

\u56e0\u679c+X\uff1a\u89e3\u51b3\u591a\u5b66\u79d1\u9886\u57df\u7684\u56e0\u679c\u95ee\u9898 | \u56e0\u679c\u79d1\u5b66\u8bfb\u4e66\u4f1a\u7b2c\u4e09\u5b63\u542f\u52a8<\/a><\/span><\/strong><\/span><\/p>\n

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\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n

\u200d<\/span>1. <\/strong>\u56e0\u679c\u63a8\u7406\u4e0e\u5927\u8bed\u8a00\u6a21\u578b\uff1a\u5f00\u8f9f\u56e0\u679c\u5173\u7cfb\u7684\u65b0\u524d\u6cbf<\/a><\/strong><\/span><\/strong><\/strong><\/section>\n
2.<\/strong> \u8bba\u6587\u6e05\u5355\uff1a\u4e00\u6587\u68b3\u7406\u56e0\u679c\u63a8\u7406\u5728\u81ea\u7136\u8bed\u8a00\u5904\u7406\u4e2d\u7684\u5e94\u7528<\/a><\/strong><\/span><\/strong><\/section>\n
3. <\/strong><\/strong>\u56e0\u679c\u63a8\u7406\u4e0e\u7a33\u5b9a\u5b66\u4e60\uff1a\u57fa\u4e8e\u79cd\u5b50\u53d8\u91cf\u7684\u7a33\u5b9a\u5b66\u4e60\u6846\u67b6<\/a><\/strong><\/strong><\/span><\/strong><\/strong><\/section>\n
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4. <\/strong><\/strong><\/span>\u5f20\u6c5f\uff1a\u7b2c\u4e09\u4ee3\u4eba\u5de5\u667a\u80fd\u6280\u672f\u57fa\u7840\u2014\u2014\u4ece\u53ef\u5fae\u5206\u7f16\u7a0b\u5230\u56e0\u679c\u63a8\u7406 | \u96c6\u667a\u5b66\u56ed\u5168\u65b0\u8bfe\u7a0b<\/a><\/strong><\/strong><\/span><\/section>\n
5. <\/strong><\/strong>\u52a0\u5165\u96c6\u667a\u5b66\u56edVIP\uff0c\u83b7\u5f9720\u5468\u5e74\u201c\u6d8c\u73b0\u201d\u5b66\u672f\u5e74\u4f1a\u5165\u573a\u5238\uff01<\/a><\/strong><\/strong><\/strong><\/strong><\/span><\/section>\n
6. <\/strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/span><\/a><\/section>\n

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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/strong><\/strong><\/span><\/strong><\/section>\n

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