{"id":45300,"date":"2023-09-20T22:51:34","date_gmt":"2023-09-20T14:51:34","guid":{"rendered":"https:\/\/swarma.org\/?p=45300"},"modified":"2023-09-20T22:51:34","modified_gmt":"2023-09-20T14:51:34","slug":"%e5%89%8d%e6%b2%bf%e8%bf%9b%e5%b1%95%ef%bc%9a%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92%e6%84%9f%e6%9f%93%e4%b8%8e%e5%85%8d%e7%96%ab%e7%b3%bb%e7%bb%9f%e5%8d%8f%e5%90%8c%e5%93%8d%e5%ba%94%e7%9a%84%e5%8a%a8","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=45300","title":{"rendered":"\u524d\u6cbf\u8fdb\u5c55\uff1a\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u4e0e\u514d\u75ab\u7cfb\u7edf\u534f\u540c\u54cd\u5e94\u7684\u52a8\u529b\u5b66\u673a\u5236"},"content":{"rendered":"
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2019\u5e74\u5f00\u59cb\u7684\u65b0\u51a0\u75c5\u6bd2<\/span>\uff08SARS-CoV-2\uff09<\/span>\u611f\u67d3\uff0c\u5f15\u8d77\u4e86\u5168\u7403\u5927\u6d41\u884c\uff0c\u7ed9\u4eba\u7c7b\u7684\u5065\u5eb7\u3001\u7ecf\u6d4e\u548c\u793e\u4f1a\u5e26\u6765\u4e86\u5de8\u5927\u7684\u635f\u5bb3\u3002SARS-CoV-2\u611f\u67d3\u4e2a\u4f53\u540e\uff0c\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u4f1a\u542f\u52a8\u4e00\u7cfb\u5217\u7684\u52a8\u6001\u54cd\u5e94\u6765\u62b5\u6297\u548c\u6e05\u9664\u75c5\u6bd2\uff0c\u4e0d\u540c\u4e2a\u4f53\u7684\u514d\u75ab\u53cd\u5e94\u5b58\u5728\u5f88\u5927\u7684\u5dee\u5f02\uff0c\u5bfc\u81f4\u4e86\u4e0d\u540c\u7a0b\u5ea6\u7684\u611f\u67d3\u548c\u75be\u75c5\u7ed3\u5c40\u3002<\/span>\u540c\u65f6\uff0cSARS-CoV-2\u4e5f\u5728\u4e0d\u65ad\u53d8\u5f02\uff0c\u4ea7\u751f\u80fd\u591f\u9003\u907f\u514d\u75ab\u4fdd\u62a4\u7684\u7a81\u53d8\u682a\uff0c\u5bf9\u75ab\u82d7\u7684\u6709\u6548\u6027\u548c\u7fa4\u4f53\u514d\u75ab\u7684\u5efa\u7acb\u5e26\u6765\u4e86\u6311\u6218\u3002<\/span><\/section>\n

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2023\u5e749\u67081\u65e5\uff0c\u5317\u4eac\u5927\u5b66\u7269\u7406\u5b66\u9662\/\u5b9a\u91cf\u751f\u7269\u5b66\u4e2d\u5fc3\u674e\u65b9\u5ef7<\/strong>\u8bfe\u9898\u7ec4\u4e0e\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u534f\u548c\u533b\u9662\u80e1\u8c6b\/\u6885\u6052<\/strong>\u56e2\u961f\u7b49\uff0c\u5728PLoS Computational Biology<\/em>\u4e0a\u53d1\u8868\u9898\u4e3aDynamical modelling of viral infection and cooperative immune protection in COVID-19 patients<\/span> (DOI: 10.1371\/journal.pcbi.1011383) <\/span>\u7684\u7814\u7a76\u8bba\u6587[4]\u3002\u5728\u8be5\u8bba\u6587\u4e2d\uff0c\u4f5c\u8005\u6784\u5efa\u4e86\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3-\u514d\u75ab\u54cd\u5e94\u7684\u6570\u5b66\u6a21\u578b\uff0c\u8ba8\u8bba\u4e86\u4e0d\u540c\u611f\u67d3\u75c7\u72b6\u60a3\u8005\u7684\u514d\u75ab\u54cd\u5e94\u52a8\u529b\u5b66\u7279\u5f81\uff0c\u63d0\u51fa\u4e86\u7efc\u5408\u8bc4\u4ef7\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u5bf9\u6297\u75c5\u6bd2\u611f\u67d3\u5f3a\u5ea6\u7684\u5b9a\u91cf\u6307\u6807\u2014\u2014\u514d\u75ab\u6548\u5ea6 (immune efficacy, \u03b5)<\/strong>\uff0c\u57fa\u4e8e\u8be5\u6307\u6807\u63d0\u51fa\u4e86\u5b9a\u91cf\u8bc4\u4f30\u75c7\u72b6\u4e25\u91cd\u6027\u548c\u9884\u6d4b\u75ab\u82d7\u4fdd\u62a4\u7387<\/strong>\u7684\u65b9\u6cd5\uff0c\u901a\u8fc7\u65b0\u51a0\u539f\u59cb\u6bd2\u682a\u548c\u7a81\u53d8\u682a\u7684\u4e34\u5e8a\u6570\u636e\u9a8c\u8bc1\u4e86\u8be5\u65b9\u6cd5\u7684\u53ef\u9760\u6027\u3002<\/span><\/section>\n

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\u7efc\u4e0a\uff0c\u8be5\u5de5\u4f5c\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5b9a\u91cf\u5206\u6790\u6846\u67b6\uff0c\u53ef\u7528\u4e8e\u7cfb\u7edf\u5730\u63cf\u8ff0SARS-CoV-2\u521d\u6b21\u4ee5\u53ca\u4e8c\u6b21\u611f\u67d3\u6240\u5f15\u8d77\u7684\u7684\u514d\u75ab\u54cd\u5e94\u52a8\u529b\u5b66\uff0c\u5e76\u9488\u5bf9\u4e0d\u540c\u4eba\u7fa4\u548c\u75c5\u6bd2\u6bd2\u682a\u6765\u5236\u5b9a\u4e2a\u6027\u5316\u6cbb\u7597\u548c\u75ab\u82d7\u9884\u9632\u7b56\u7565\u3002\u4e3a\u4e86\u7406\u89e3\u65b0\u51a0\u611f\u67d3\u540e\u4e0d\u540c\u75c7\u72b6\u7684\u4ea7\u751f\u673a\u5236\uff0c\u57fa\u4e8e\u75c5\u6bd2\u52a8\u529b\u5b66\u548c\u708e\u75c7\u6c34\u5e73\u5c06\u611f\u67d3\u4eba\u7fa4\u5206\u6210\u56db\u7c7b\uff0c\u8ba8\u8bba\u4e86\u4e0d\u540c\u7c7b\u60a3\u8005\u7684\u514d\u75ab\u54cd\u5e94\u7279\u5f81\uff0c\u5e76\u7ed9\u51fa\u76f8\u5e94\u7684\u6cbb\u7597\u7b56\u7565\u3002\u8be5\u5de5\u4f5c\u63d0\u51fa\u4e86\u5b9a\u91cf\u8bc4\u4ef7\u514d\u75ab\u53cd\u5e94\u5f3a\u5ea6\u7684\u6307\u6807\uff0c\u5373\u514d\u75ab\u6548\u5ea6\uff0c\u53ef\u7531\u7ec6\u80de\u514d\u75ab\u4e0e\u4f53\u6db2\u514d\u75ab\u7684\u4e58\u79ef\u6240\u63cf\u8ff0\uff0c\u63ed\u793a\u4e86\u7ec6\u80de\u548c\u4f53\u6db2\u514d\u75ab\u5171\u540c\u534f\u4f5c\u62b5\u5fa1\u75c5\u6bd2\u7684\u52a8\u529b\u5b66\u673a\u5236\uff0c\u5e76\u5f3a\u8c03\u4e86T\u7ec6\u80de\u5728\u75ab\u82d7\u4fdd\u62a4\u4e2d\u4e0d\u53ef\u6216\u7f3a\u7684\u4f5c\u7528\u3002\u8fdb\u4e00\u6b65\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u80fd\u4fbf\u6377\u8bc4\u4ef7\u4e34\u5e8a\u60a3\u8005\u514d\u75ab\u529b\u7684\u6307\u6807\u2014\u2014\u4e34\u5e8a\u514d\u75ab\u6548\u5ea6<\/span>\uff08\u57fa\u4e8e\u8840\u5e38\u89c4\u7ed3\u679c\u8ba1\u7b97\u5f97\u5230\uff09<\/span>\uff0c\u4ee5\u53ca\u5229\u7528\u514d\u75ab\u6548\u5ea6\u9884\u6d4b\u75ab\u82d7\u4fdd\u62a4\u7387\u7684\u65b9\u6cd5\uff0c\u76f8\u5173\u7814\u7a76\u5df2\u83b7\u5f97\u4e2d\u56fd\u4e13\u5229\u6388\u6743<\/span>\uff08CN115184614A\uff09<\/span>\u3002\u6b64\u5916\uff0c\u8be5\u8bfe\u9898\u7ec4\u4e5f\u6784\u5efa\u4e86\u4e2a\u4f53\u5185\u65b0\u51a0\u611f\u67d3\u4e0e\u514d\u75ab\u54cd\u5e94\u7684\u5faa\u73af\u6a21\u578b\uff0c\u7814\u7a76\u4e86\u4e0d\u540c\u5668\u5b98\u5185\u514d\u75ab\u5e94\u7b54\u7279\u5f81\u548c\u514d\u75ab\u7ec6\u80de\u5728\u514d\u75ab\u5668\u5b98\u95f4\u7684\u8d8b\u5316\u8fc1\u79fb\u884c\u4e3a\uff0c\u8be5\u6a21\u578b\u80fd\u66f4\u5168\u9762\u5730\u63cf\u8ff0\u65b0\u51a0\u60a3\u8005\u7684\u5168\u8eab\u6027\u514d\u75ab\u53cd\u5e94[5]\u3002<\/span><\/section>\n

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\u5317\u4eac\u5927\u5b66\u7269\u7406\u5b66\u9662\u5468\u6b63\u6e05\u3001\u674e\u5178\u6770\u3001\u5317\u4eac\u5927\u5b66\u57fa\u7840\u533b\u5b66\u9662\u8d75\u5b50\u6052\u3001\u5317\u4eac\u5927\u5b66\u7b2c\u4e09\u533b\u9662\u53f2\u4e66\u6bd3\u548c\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u534f\u548c\u533b\u9662\u5434\u6c5f\u534e\u4e3a\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3002\u5317\u4eac\u5927\u5b66\u7269\u7406\u5b66\u9662\/\u5b9a\u91cf\u751f\u7269\u5b66\u4e2d\u5fc3\u674e\u65b9\u5ef7\u526f\u6559\u6388\u3001\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u534f\u548c\u533b\u9662\u80e1\u8c6b\u6559\u6388\u548c\u6885\u6052\u6559\u6388\u4e3a\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002\u8be5\u7814\u7a76\u5f97\u5230\u4e86\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u3001\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u7b49\u673a\u6784\u7684\u652f\u6301\u3002<\/span><\/section>\n

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\u53c2\u8003\u6587\u732e\uff1a<\/span><\/strong><\/span><\/section>\n
1. J. Hadjadj et al.<\/em>, Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients. Science<\/em> 369, 718-724 (2020).<\/span><\/section>\n
2. B. Chatterjee, H. Singh Sandhu, N. M. Dixit, Modeling recapitulates the heterogeneous outcomes of SARS-CoV-2 infection and quantifies the differences in the innate immune and CD8 T-cell responses between patients experiencing mild and severe symptoms. PLOS Pathogens<\/em> 18, e1010630 (2022).<\/span><\/section>\n
3. D. S. Khoury et al.<\/em>, Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection. Nature Medicine<\/em> 27, 1205-1211 (2021).<\/span><\/section>\n
4. Zhou Z, Li D, Zhao Z, Shi S, Wu J, et al. (2023) Dynamical modelling of viral infection and cooperative immune protection in COVID-19 patients. PLOS Computational Biology<\/em> 19(9): e1011383. https:\/\/doi.org\/10.1371\/journal.pcbi.1011383<\/span><\/section>\n
5. Li J, Wu J, Zhang J, Tang L, Mei H, Hu Y, Li F. A multicompartment mathematical model based on host immunity for dissecting COVID-19 heterogeneity. Heliyon<\/em>. 2022 May;8(5):e09488. doi: 10.1016\/j.heliyon.2022.e09488. (https:\/\/mp.weixin.qq.com\/s\/PBxs1hbLKM1slX6Fx_zz-Q)<\/span><\/section>\n

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\u751f\u547d\u590d\u6742\u6027\u7cfb\u5217\u8bfb\u4e66\u4f1a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u751f\u547d\u590d\u6742\u6027\u7cfb\u5217\u8bfb\u4e66\u4f1a\uff1a\u4ece\u4fe1\u606f\u548c\u7269\u7406\u89c6\u89d2\u63a2\u7d22\u751f\u547d\u7684\u5185\u5728\u903b\u8f91<\/a><\/span><\/strong><\/span><\/p>\n


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\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n

1. <\/strong> <\/strong>\u4fe1\u606f\u6d41\u884c\u75c5\u7efc\u8ff0\uff1a\u865a\u5047\u4fe1\u606f\u7684\u6613\u611f\u6027\u3001\u4f20\u64ad\u548c\u514d\u75ab<\/a><\/strong><\/span><\/strong><\/section>\n
2.<\/strong>  \u65b0\u51a0\u80ba\u708e\u5f15\u8d77\u7684\u4e0d\u540c\u514d\u75ab\u5668\u5b98\u5185\u514d\u75ab\u5e94\u7b54\u7684\u5b9a\u91cf\u6a21\u578b\u7814\u7a76<\/a><\/strong><\/span><\/section>\n
3.  <\/strong><\/strong>PRX \u901f\u9012\uff1a\u8fde\u63a5\u7269\u7406\u673a\u5236\u548c\u6f14\u5316\u529f\u80fd\uff0c\u5206\u5b50\u62d4\u6cb3\u63ed\u793a\u514d\u75ab\u7ec6\u80de\u5e93\u9002\u5e94\u6f5c\u529b<\/a><\/strong><\/strong><\/span><\/strong><\/strong><\/section>\n
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4. <\/strong><\/span>\u5f20\u6c5f\uff1a\u7b2c\u4e09\u4ee3\u4eba\u5de5\u667a\u80fd\u6280\u672f\u57fa\u7840\u2014\u2014\u4ece\u53ef\u5fae\u5206\u7f16\u7a0b\u5230\u56e0\u679c\u63a8\u7406 | \u96c6\u667a\u5b66\u56ed\u5168\u65b0\u8bfe\u7a0b<\/a><\/strong><\/strong><\/span><\/section>\n
5. <\/strong>\u6210\u4e3a\u96c6\u667aVIP\uff0c\u89e3\u9501\u5168\u7ad9\u8bfe\u7a0b\uff0f\u8bfb\u4e66\u4f1a<\/a><\/span><\/strong><\/section>\n
6. <\/strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/span><\/a><\/section>\n


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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u8ffd\u8e2a\u590d\u6742\u79d1\u5b66\u9876\u520a\u8bba\u6587<\/strong><\/span><\/strong><\/span><\/strong><\/span><\/p>\n

<\/mp-style-type><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bfc\u8bed \u8fd1\u65e5\uff0c\u5317\u4eac\u5927\u5b66\u7269\u7406\u5b66\u9662\/\u5b9a\u91cf\u751f\u7269\u5b66\u4e2d\u5fc3\u674e\u65b9\u5ef7\u8bfe\u9898\u7ec4\u4e0e\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u534f\u548c\u533b\u9662\u80e1\u8c6b\/\u6885\u6052\u56e2\u961f\u7b49\uff0c\u5728 PLoS Computational Biology \u4e0a\u53d1\u8868\u6700\u65b0\u7814\u7a76\uff0c\u6784\u5efa\u4e86\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3-\u514d\u75ab\u54cd\u5e94\u7684\u6570\u5b66\u6a21\u578b\uff0c\u8ba8\u8bba\u4e0d\u540c\u611f\u67d3\u75c7\u72b6\u60a3\u8005\u7684\u514d\u75ab\u54cd\u5e94\u52a8\u529b\u5b66\u7279\u5f81\uff0c\u63d0\u51fa\u4e86\u7efc\u5408\u8bc4\u4ef7\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u5bf9\u6297\u75c5\u6bd2…<\/p>\n","protected":false},"author":0,"featured_media":45296,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/45300"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=45300"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/45300\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/45296"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=45300"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=45300"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=45300"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=45300"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}