{"id":45310,"date":"2023-09-21T22:00:16","date_gmt":"2023-09-21T14:00:16","guid":{"rendered":"https:\/\/swarma.org\/?p=45310"},"modified":"2023-09-21T22:00:16","modified_gmt":"2023-09-21T14:00:16","slug":"%e4%b8%a4%e7%af%87-nature-%e8%bf%9e%e5%8f%91%ef%bc%9a%e7%85%a7%e4%ba%ae%e8%9b%8b%e7%99%bd%e8%b4%a8%e5%ae%87%e5%ae%99%e4%b8%ad%e7%9a%84%e6%9a%97%e7%89%a9%e8%b4%a8","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=45310","title":{"rendered":"\u4e24\u7bc7 Nature \u8fde\u53d1\uff1a\u7167\u4eae\u86cb\u767d\u8d28\u5b87\u5b99\u4e2d\u7684\u201c\u6697\u7269\u8d28\u201d"},"content":{"rendered":"
\n
\n
\n
\n

<\/p>\n


<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/p>\n

\u5173\u952e\u8bcd\uff1a\u673a\u5668\u5b66\u4e60\uff0c\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\uff0c\u805a\u7c7b\u7b97\u6cd5\uff0c\u81ea\u7136\u6f14\u5316\uff0c<\/span><\/strong>\u86cb\u767d\u8d28\u5b87\u5b99\uff0c\u673a\u5668\u5b66\u4e60\uff0c\u751f\u7269\u4fe1\u606f\u5b66<\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/p>\n


<\/p>\n<\/section>\n

\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
\n


<\/p>\n


<\/p>\n<\/section>\n

Nature \u901f\u9012\uff1a\u5728\u5df2\u77e5\u86cb\u767d\u8d28\u5b87\u5b99\u5c3a\u5ea6\u4e0a\u805a\u7c7b\u9884\u6d4b\u7684\u7ed3\u6784<\/span><\/strong><\/span><\/h2>\n

<\/section>\n
<\/section>\n
\n
\n
\n
\n
\u8bba\u6587\u6807\u9898\uff1aClustering-predicted structures at the scale of the known protein universe<\/span><\/section>\n
\u8bba\u6587\u6765\u6e90\uff1aNature<\/em><\/span><\/section>\n
\u6591\u56fe\u94fe\u63a5\uff1ahttps:\/\/pattern.swarma.org\/paper\/566b6b70-5289-11ee-8c54-0242ac17000d<\/span><\/section>\n
\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41586-023-06510-w<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n

<\/section>\n
\u86cb\u767d\u8d28\u5728\u6240\u6709\u7ec6\u80de\u8fc7\u7a0b\u4e2d\u90fd\u8d77\u7740\u5173\u952e\u4f5c\u7528\uff0c\u5176\u7ed3\u6784\u5bf9\u4e8e\u7406\u89e3\u5176\u529f\u80fd\u548c\u6f14\u5316\u81f3\u5173\u91cd\u8981\u3002\u57fa\u4e8e\u5e8f\u5217\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7684\u51c6\u786e\u6027\u4e0d\u65ad\u63d0\u9ad8\uff0cAlphaFold \u6570\u636e\u5e93\u4e2d\u63d0\u4f9b\u4e86\u8d85\u8fc72.14\u4ebf\u4e2a\u9884\u6d4b\u7ed3\u6784\uff0c\u800c\u4ee5\u8fd9\u79cd\u89c4\u6a21\u7814\u7a76\u86cb\u767d\u8d28\u7ed3\u6784\u9700\u8981\u9ad8\u6548\u7684\u65b9\u6cd5\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u6587\u7ae0\u5f00\u53d1\u4e86\u4e00\u79cd\u57fa\u4e8e\u7ed3\u6784\u6bd4\u5bf9\u7684\u805a\u7c7b\u7b97\u6cd5\u2014\u2014Foldseek cluster\uff0c\u53ef\u4ee5\u5bf9\u6570\u4ebf\u4e2a\u7ed3\u6784\u8fdb\u884c\u805a\u7c7b<\/strong>\u3002\u4f7f\u7528\u8fd9\u79cd\u65b9\u6cd5\uff0c\u4f5c\u8005\u5bf9 AlphaFold \u6570\u636e\u5e93\u4e2d\u7684\u6240\u6709\u7ed3\u6784\u8fdb\u884c\u4e86\u805a\u7c7b\uff0c\u8bc6\u522b\u51fa230\u4e07\u4e2a\u975e\u5355\u4f53\u7ed3\u6784\u805a\u7c7b\uff0c\u5176\u4e2d31%\u6ca1\u6709\u6ce8\u91ca\uff0c\u4ee3\u8868\u53ef\u80fd\u662f\u4ee5\u524d\u672a\u63cf\u8ff0\u7684\u7ed3\u6784\u3002\u6ca1\u6709\u6ce8\u91ca\u7684\u805a\u7c7b\u53ea\u5177\u6709\u5c11\u91cf\u4ee3\u8868\uff0c\u4ec5\u8986\u76d6 AlphaFold \u6570\u636e\u5e93\u4e2d\u6240\u6709\u86cb\u767d\u8d28\u76844%\u3002\u6f14\u5316\u5206\u6790\u8868\u660e\uff0c\u5927\u591a\u6570\u805a\u7c7b\u5177\u6709\u53e4\u8001\u7684\u8d77\u6e90\uff0c\u4f464%\u4f3c\u4e4e\u662f\u7269\u79cd\u7279\u5b9a\u7684\uff0c\u4ee3\u8868\u9884\u6d4b\u8d28\u91cf\u8f83\u4f4e\u6216\u65b0\u751f\u57fa\u56e0\u7684\u793a\u4f8b\u3002<\/span><\/section>\n

<\/span><\/section>\n
<\/section>\n
\u56fe1 \u805a\u7c7b\u7684\u6f14\u5316\u5206\u5e03\u548c\u4ee5\u4eba\u4e3a\u4e2d\u5fc3\u7684\u805a\u7c7b\u5206\u6790<\/span><\/section>\n

<\/span><\/section>\n
\u6587\u7ae0\u8fd8\u5c55\u793a\u4e86\u5982\u4f55\u5229\u7528\u7ed3\u6784\u6bd4\u8f83\u6765\u9884\u6d4b\u7ed3\u6784\u57df\u5bb6\u65cf\u53ca\u5176\u5173\u7cfb\uff0c\u8bc6\u522b\u8fdc\u7a0b\u7ed3\u6784\u76f8\u4f3c\u6027\u7684\u793a\u4f8b\u3002<\/span><\/section>\n

<\/span><\/section>\n
<\/section>\n
\u56fe2 \u4e0e\u5df2\u6ce8\u91ca\u7684\u57df\u5bb6\u65cf\u5b58\u5728\u7ed3\u6784\u76f8\u4f3c\u6027\u7684\u672a\u6ce8\u91ca\u57df\u5bb6\u65cf\u793a\u4f8b<\/span><\/section>\n

<\/section>\n
\u57fa\u4e8e\u8fd9\u4e9b\u5206\u6790\uff0c\u4f5c\u8005\u786e\u5b9a\u4e86\u4e00\u4e9b\u4eba\u7c7b\u514d\u75ab\u76f8\u5173\u86cb\u767d\u8d28\u7684\u6f5c\u5728\u8fdc\u7a0b\u540c\u6e90\u6027\u5728\u539f\u6838\u751f\u7269\u4e2d\uff0c\u8fd9\u8bf4\u660e\u8fd9\u4e00\u8d44\u6e90\u5728\u8de8\u751f\u547d\u6811\u7814\u7a76\u86cb\u767d\u8d28\u529f\u80fd\u548c\u6f14\u5316\u65b9\u9762\u7684\u4ef7\u503c\u3002<\/span><\/section>\n

<\/span><\/section>\n

<\/span><\/section>\n

Nature\u901f\u9012\uff1a\u63ed\u793a\u81ea\u7136\u86cb\u767d\u8d28\u5b87\u5b99\u4e2d\u7684\u65b0\u5bb6\u65cf\u548c\u65b0\u6298\u53e0<\/span><\/strong><\/span><\/h2>\n

<\/span><\/section>\n
<\/span><\/section>\n
\n
\n
\n
\n
\u8bba\u6587\u9898\u76ee\uff1a<\/span>Uncovering new families and folds in the natural protein universe<\/span><\/section>\n
\u671f\u520a\u540d\u79f0\uff1aNature<\/em><\/span><\/section>\n
\u6591\u56fe\u5730\u5740\uff1ahttps:\/\/pattern.swarma.org\/paper\/4b9269c4-5289-11ee-8c54-0242ac17000d<\/span><\/section>\n
\u8bba\u6587\u5730\u5740\uff1ahttps:\/\/www.nature.com\/articles\/s41586-023-06622-3<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n

<\/section>\n
\u6211\u4eec\u6b63\u8fdb\u5165\u86cb\u767d\u8d28\u5e8f\u5217\u548c\u7ed3\u6784\u6ce8\u91ca\u7684\u65b0\u65f6\u4ee3\uff0c\u901a\u8fc7 AlphaFold \u6570\u636e\u5e93\u53ef\u4ee5\u83b7\u5f97\u6570\u4ebf\u4e2a\u9884\u6d4b\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u3002\u8fd9\u4e9b\u6a21\u578b\u51e0\u4e4e\u8986\u76d6\u6240\u6709\u5df2\u77e5\u86cb\u767d\u8d28\uff0c\u5305\u62ec\u90a3\u4e9b\u4f7f\u7528\u6807\u51c6\u7684\u57fa\u4e8e\u540c\u6e90\u6027\u7684\u65b9\u6cd5\u96be\u4ee5\u6ce8\u91ca<\/span>\u5176\u529f\u80fd\u6216\u5047\u5b9a\u7684\u751f\u7269\u5b66\u4f5c\u7528\u7684\u86cb\u767d\u8d28\u3002<\/span><\/section>\n

<\/span><\/section>\n
<\/section>\n

\u56fe1. UniProt \u548c AlphaFold \u6570\u636e\u5e93\u4e2d\u96c6\u5408\u3001\u5206\u7c7b\u548c\u6620\u5c04\u672a\u77e5\u529f\u80fd\u86cb\u767d\u8d28\u7684\u5de5\u4f5c\u6d41\u3002<\/span><\/p>\n


<\/span><\/section>\n
\u8fd9\u9879\u5de5\u4f5c\u7814\u7a76\u4e86 AlphaFold \u6570\u636e\u5e93\u5728\u591a\u5927\u7a0b\u5ea6\u4e0a\u4ee5\u9ad8\u9884\u6d4b\u7cbe\u5ea6\u7167\u4eae\u4e86\u81ea\u7136\u86cb\u767d\u8d28\u5b87\u5b99\u7684\u201c\u6697\u7269\u8d28\u201d\u3002\u7814\u7a76\u8fdb\u4e00\u6b65\u63cf\u8ff0\u4e86\u8fd9\u4e9b\u6a21\u578b\u8986\u76d6\u7684\u86cb\u767d\u8d28\u591a\u6837\u6027\uff0c\u4ee5\u5e26\u6ce8\u91ca\u7684\u4e92\u52a8\u5e8f\u5217\u76f8\u4f3c\u6027\u7f51\u7edc\u7684\u5f62\u5f0f\u5448\u73b0\uff0c\u53ef\u8bbf\u95eehttps:\/\/uniprot3d.org\/atlas\/AFDB90v4<\/span> \u3002<\/span><\/section>\n

<\/span><\/section>\n
<\/section>\n

\u56fe2. AFDB\uff08AFDB90\uff09\u4e2d\u8d85\u8fc7600\u4e07\u4e2a UniRef50 \u7c07\u4ee3\u8868\u86cb\u767d\u8d28\u7684\u5927\u89c4\u6a21\u5e8f\u5217\u76f8\u4f3c\u6027\u7f51\u7edc\uff0c\u5177\u6709\u9ad8\u5ea6\u9884\u6d4b\u51c6\u786e\u6027\u7684\u6a21\u578b\u3002<\/span><\/p>\n


<\/span><\/section>\n
\u901a\u8fc7\u4ece\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u8bed\u4e49\u89d2\u5ea6\u641c\u7d22\u65b0\u9896\u6027\uff0c\u7814\u7a76\u63ed\u793a\u4e86\u03b2-\u82b1\u74e3\u6298\u53e0\u7ed3\u6784\uff0c\u5411 Pfam \u6570\u636e\u5e93\u4e2d\u6dfb\u52a0\u4e86\u591a\u4e2a\u86cb\u767d\u8d28\u5bb6\u65cf\uff0c\u5e76\u5728\u5b9e\u9a8c\u4e2d\u8bc1\u660e\u5176\u4e2d\u4e4b\u4e00\u5c5e\u4e8e\u65b0\u7684\u7ffb\u8bd1\u9776\u5411\u6bd2\u7d20-\u6297\u6bd2\u7d20\u7cfb\u7edf\u8d85\u5bb6\u65cf TumE-TumA\u3002<\/span><\/section>\n

<\/span><\/section>\n
<\/section>\n
\u56fe3. \u5173\u8054\u90e8\u5206159\u662f\u6bd2\u7d20-\u6297\u6bd2\u7d20\u8d85\u5bb6\u65cf TumE-TumA \u4e2d\u7684\u65b0\u6bd2\u7d20\u3002<\/span><\/section>\n

<\/section>\n
\u8fd9\u9879\u5de5\u4f5c\u5f3a\u8c03\u4e86\u5728\u8bc6\u522b\u3001\u6ce8\u91ca\u548c\u4f18\u5148\u8003\u8651\u65b0\u86cb\u767d\u8d28\u5bb6\u65cf\u65b9\u9762\u5927\u89c4\u6a21\u52aa\u529b\u7684\u4ef7\u503c\u3002\u5229\u7528\u86cb\u767d\u8d28\u751f\u7269\u4fe1\u606f\u5b66\u9886\u57df\u7684\u6700\u65b0\u6df1\u5ea6\u5b66\u4e60\u9769\u547d\uff0c\u6211\u4eec\u73b0\u5728\u80fd\u8fc7\u4ee5\u524d\u6240\u672a\u6709\u7684\u89c4\u6a21\u7167\u4eae\u86cb\u767d\u8d28\u5b87\u5b99\u7684\u672a\u77e5\u9886\u57df\uff0c\u4e3a\u751f\u547d\u79d1\u5b66\u548c\u751f\u7269\u6280\u672f\u521b\u65b0\u94fa\u5e73\u9053\u8def\u3002<\/span><\/section>\n

<\/section>\n
\n

<\/span><\/section>\n
\u7f16\u8bd1\uff5c\u8463\u4f73\u6b23\u3001\u6881\u91d1<\/span><\/span><\/section>\n

<\/span><\/span><\/section>\n
\n
\n
\n
\n

\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1a<\/strong><\/p>\n

AI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a\u542f\u52a8<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/section>\n

<\/span><\/a><\/p>\n


<\/p>\n

\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/p>\n

\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1aAI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a\u542f\u52a8<\/a><\/span>
<\/span><\/p>\n


<\/p>\n


<\/p>\n

\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n

\u200d<\/span>1. <\/strong>Nat. Mach. Intell.\u901f\u9012\uff1atransformer \u7f51\u7edc\u8bc4\u4ef7\u86cb\u767d\u8d28\u7ed3\u5408\u754c\u9762<\/a><\/strong><\/span><\/strong><\/strong><\/section>\n
2.<\/strong> PNAS \u901f\u9012\uff1a\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u4e2d transformer \u7684\u53d8\u6362\u80fd\u529b<\/a><\/strong><\/span><\/strong><\/section>\n
3. <\/strong><\/strong>\u5df4\u62c9\u5df4\u897f\u65b0\u4f5c\uff1aAI-Bind \u52a9\u529b\u86cb\u767d\u8d28-\u914d\u4f53\u7ed3\u5408\u9884\u6d4b<\/a><\/strong><\/strong><\/span><\/strong><\/strong><\/section>\n
<\/strong><\/strong><\/strong><\/section>\n
4. <\/strong><\/strong><\/span>\u5f20\u6c5f\uff1a\u7b2c\u4e09\u4ee3\u4eba\u5de5\u667a\u80fd\u6280\u672f\u57fa\u7840\u2014\u2014\u4ece\u53ef\u5fae\u5206\u7f16\u7a0b\u5230\u56e0\u679c\u63a8\u7406 | \u96c6\u667a\u5b66\u56ed\u5168\u65b0\u8bfe\u7a0b<\/a><\/strong><\/strong><\/span><\/section>\n
5. <\/strong><\/strong>\u6210\u4e3a\u96c6\u667aVIP\uff0c\u89e3\u9501\u5168\u7ad9\u8bfe\u7a0b\uff0f\u8bfb\u4e66\u4f1a<\/a><\/span><\/strong><\/strong><\/strong><\/section>\n
6. <\/strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/span><\/a><\/section>\n

<\/section>\n

<\/section>\n
\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/strong><\/span><\/strong><\/section>\n

<\/mp-style-type><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5173\u952e\u8bcd\uff1a\u673a\u5668\u5b66\u4e60\uff0c\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\uff0c\u805a\u7c7b\u7b97\u6cd5\uff0c\u81ea\u7136\u6f14\u5316\uff0c\u86cb\u767d\u8d28\u5b87\u5b99\uff0c\u673a\u5668\u5b66\u4e60\uff0c\u751f\u7269\u4fe1\u606f\u5b66 Nature \u901f\u9012\uff1a\u5728\u5df2\u77e5\u86cb\u767d\u8d28\u5b87\u5b99\u5c3a\u5ea6\u4e0a\u805a\u7c7b\u9884\u6d4b\u7684\u7ed3\u6784 \u8bba\u6587\u6807\u9898\uff1aClustering-predicted structures at the scale of the known protein univer…<\/p>\n","protected":false},"author":0,"featured_media":45301,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/45310"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=45310"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/45310\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/45301"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=45310"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=45310"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=45310"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=45310"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}