{"id":45985,"date":"2023-10-24T21:45:25","date_gmt":"2023-10-24T13:45:25","guid":{"rendered":"https:\/\/swarma.org\/?p=45985"},"modified":"2023-10-24T21:45:25","modified_gmt":"2023-10-24T13:45:25","slug":"pnas%e9%80%9f%e9%80%92%ef%bc%9a%e5%9f%ba%e4%ba%8e%e5%a4%8d%e6%9d%82%e7%bd%91%e7%bb%9c%e4%b8%8e%e6%bc%94%e5%8c%96%e5%8d%9a%e5%bc%88%ef%bc%8c%e7%a0%94%e7%a9%b6%e5%a4%8d%e6%9d%82%e7%96%be%e7%97%85","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=45985","title":{"rendered":"PNAS\u901f\u9012\uff1a\u57fa\u4e8e\u590d\u6742\u7f51\u7edc\u4e0e\u6f14\u5316\u535a\u5f08\uff0c\u7814\u7a76\u590d\u6742\u75be\u75c5\u4ee3\u8c22\u7279\u5f81"},"content":{"rendered":"
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\u8bba\u6587\u5730\u5740\uff1a<\/span><\/section>\n
The metabolomic physics of complex diseases<\/span><\/o:p><\/section>\n
\u8bba\u6587\u6807\u9898\uff1a<\/span><\/section>\n
https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2308496120<\/span><\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n


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3. \u4e0d\u540c\u5e74\u9f84\u95f4\u7684\u4ee3\u8c22\u7f51\u7edc\u5b58\u5728\u5dee\u5f02<\/strong><\/strong><\/strong><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n
 <\/span><\/section>\n
\u8870\u8001\u662f\u8eab\u4f53\u548c\u4ee3\u8c22\u529f\u80fd\u7684\u6301\u7eed\u4e0b\u964d\uff0c\u4e0e\u75be\u75c5\u7684\u6613\u611f\u6027\u589e\u52a0\u5bc6\u5207\u76f8\u5173\u3002\u5c06\u5065\u5eb7\u7ec4\u3001UC\u548cCD\u7ec4\u5206\u522b\u6309\u7167\u5e74\u9f84\u5206\u4e3a4\u7ec4\uff0c\u4e4b\u540e\u5bf9\u4ee3\u8c22\u7f51\u7edc\u8fdb\u884c\u7c97\u7c92\u5316\u3002\u53d1\u73b0\u5bf9 HC \u7ec4\u6765\u8bf4<\/span>\uff08\u56fe2A\uff09<\/span>\uff0c\u4ee3\u8c22\u7f51\u7edc\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u76f8\u5bf9\u7a33\u5b9a\uff0c\u4f46\u5bf9 CD \u7ec4\u6765\u8bf4\u5219\u663e\u793a\u51fa\u5de8\u5927\u7684\u53d8\u5316\u3002UC \u7ec4\u7684\u4e00\u4e9b\u76f8\u4e92\u4f5c\u7528\u968f\u7740\u5e74\u9f84\u7684\u53d8\u5316\u800c\u53d8\u5316\uff1b\u4f8b\u5982\uff0c\u4ece18\u5c81\u523060\u5c81\uff0cM3\u4fc3\u8fdb M5\u7684\u5f3a\u5ea6\u589e\u52a0\uff0c\u4f46\u662f\u5f53\u5e74\u9f84\u5927\u4e8e60\u5c81\u65f6\uff0c\u8fd9\u79cd\u4fc3\u8fdb\u8f6c\u53d8\u4e3a M3\u6291\u5236 M5<\/span>\uff08\u56fe2B\uff09<\/span>\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u4ee3\u8c22\u7f51\u7edc\u5bf9\u8870\u8001\u7684\u53cd\u5e94\u5728\u5065\u5eb7\u4eba\u7fa4\u548c IBD \u4eba\u7fa4\u4e4b\u95f4\u4ee5\u53ca CD \u548c UC \u4eba\u7fa4\u4e4b\u95f4\u9075\u5faa\u4e0d\u540c\u7684\u673a\u5236\u3002<\/strong><\/span><\/o:p><\/section>\n

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M9\u7684\u72ec\u7acb\u6210\u5206<\/span>\uff08\u53cd\u6620\u5176\u5185\u5728\u80fd\u529b\uff09<\/span>\u968f\u7740\u5065\u5eb7\u548c\u60a3\u75c5\u4eba\u7fa4\u7684\u5e74\u9f84\u5927\u5e45\u589e\u52a0\uff0c\u8fd9\u610f\u5473\u7740 M9\u7684\u5185\u5728\u8868\u8fbe\u589e\u52a0\u662f\u4ee3\u8c22\u529f\u80fd\u8001\u5316\u7684\u4fe1\u53f7\u3002\u7136\u800c\uff0cM9\u53d7\u5176\u4ed6\u6a21\u5757\u5f71\u54cd\u7684\u6a21\u5f0f\u5728\u4e09\u4e2a\u7ec4\u4e4b\u95f4\u6709\u6240\u4e0d\u540c\u3002\u5065\u5eb7\u4eba\u7fa4\u7684\u7f51\u7edc\u7ec4\u7ec7\u548c\u7ed3\u6784\u5728\u8d85\u9f84\u65f6\u6bd4\u75c5\u4eba\u7fa4\u4f53\u66f4\u7a33\u5b9a\u3002\u4ece\u4e00\u4e2a\u5065\u5eb7\u72b6\u6001\u4e0b\u7684\u4e2d\u5fc3\u6a21\u5757\u8f6c\u79fb\u5230\u75be\u75c5\u72b6\u6001\u65f6\u4f1a\u6539\u53d8\u5b83\u4eec\u7684\u7f51\u7edc\u62d3\u6251\uff0c\u8fd9\u4e00\u6539\u53d8\u663e\u793a\u51fa\u660e\u663e\u7684\u5e74\u9f84\u7279\u5f02\u6027\u53d8\u5316\u3002<\/span><\/o:p><\/section>\n

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\u56fe2 \u4e0d\u540c\u5e74\u9f84\u6bb5\u7684\u88ab\u8bd5\u5728\u4e09\u79cd\u60c5\u51b5\u4e0b\u7684\u4ee3\u8c22\u7f51\u7edc<\/span><\/o:p><\/section>\n


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4. \u75be\u75c5\u7f51\u7edc\u6bd4\u5065\u5eb7\u7f51\u7edc\u5728\u62d3\u6251\u7ed3\u6784\u4e0a\u66f4\u590d\u6742<\/strong><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n
 <\/span><\/section>\n
GLMY \u540c\u8c03\u7406\u8bba<\/span>\uff08GLMY-homology\uff09<\/span>\u53ef\u5206\u6790\u7f51\u7edc\u62d3\u6251\u7ed3\u6784\u7684\u590d\u6742\u6027\u3002\u5bf9\u4e8e\u7c97\u7c92\u5316\u540e\u7684\u4ee3\u8c22\u7f51\u7edc\u7684\u6bcf\u4e2a\u529f\u80fd\u6a21\u5757\uff0c\u8003\u5bdf\u5176\u540c\u8c03\u7fa4\u7684\u79e9\uff0c\u5373\u8d1d\u8482\u6570<\/span>\uff08Betti number\uff09<\/span>\uff0c\u4ee3\u8868\u8be5\u7ef4\u5ea6\u4e0b\u7684\u7f51\u7edc\u590d\u6742\u6027\u3002\u53ef\u77e5CD \u548c UC \u7f51\u7edc\u7684\u4e2d\u5fc3M3\u5728\u7b2c\u4e00\u7ef4\u548c\u7b2c\u4e8c\u7ef4\u4e0a\u6bd4\u5065\u5eb7\u7f51\u7edcM8\u8868\u73b0\u51fa\u66f4\u591a\u7684\u62d3\u6251\u7279\u5f81\u3002\u56e0\u6b64\u53ef\u4ee5\u63a8\u65ad\uff0c\u75be\u75c5\u7f51\u7edc\u6bd4\u5065\u5eb7\u7f51\u7edc\u66f4\u590d\u6742\u3002<\/strong><\/span><\/o:p><\/section>\n

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<\/o:p><\/section>\n
\u56fe3 UC\u3001CD\u4e0e\u5bf9\u7167\u7ec4\u7c97\u7c92\u5316\u4ee3\u8c22\u7f51\u7edc\u7684\u4e2d\u5fc3\u62d3\u6251\u590d\u6742\u5ea6\u7684\u5bf9\u6bd4<\/span><\/o:p><\/section>\n

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\u901a\u8fc7\u57280,1\u548c2\u7ef4\u5ea6\u4e0a\u6839\u636e Betti \u6570<\/span>\uff08\u540c\u8c03\u6027\u79e9\uff09<\/span>\u5256\u6790\u4ee3\u8c22\u7f51\u7edc\uff0c\u8003\u8651\u4e09\u7ec4\u6a21\u5757 M3\u7684\u8d1f\u8fb9\u5bfc\u51fa\u5b50\u7f51\u7edc<\/span>\uff08\u56fe4\uff09<\/span>\u3002HC \u548c UC \u5728\u7b2c\u4e00\u7ef4\u4e0a\u5404\u6709\u4e09\u4e2a\u5b54<\/span>\uff08\u62d3\u6251\u7279\u5f81\uff09<\/span>\uff0c\u4f46\u662f\u8fd9\u4e9b\u62d3\u6251\u7279\u5f81\u5728\u4e24\u7ec4\u4e4b\u95f4\u662f\u4e0d\u540c\u7684\u3002<\/span><\/section>\n

<\/section>\n
\u4e9a\u6cb9\u9178\u662f\u4e00\u79cd\u591a\u4e0d\u9971\u548c \u03c9-6\u8102\u80aa\u9178\uff0c\u5b83\u7684\u4ee3\u8c22\u5bf9\u5065\u5eb7\u81f3\u5173\u91cd\u8981\u3002\u8be5\u53d1\u73b0\u610f\u5473\u7740\u5065\u5eb7\u72b6\u6001\u548c\u75be\u75c5\u72b6\u6001\u4e4b\u95f4\u7684\u62d3\u6251\u5dee\u5f02\uff0c\u53ef\u4ee5\u7528\u5176\u4ed6\u4ee3\u8c22\u4ea7\u7269\u5bf9\u4e9a\u6cb9\u9178\u7684\u6291\u5236\u5f3a\u5ea6\u6765\u89e3\u91ca\u3002<\/strong><\/span><\/section>\n

<\/span><\/section>\n
\u4e3a\u4e86\u4f7f UC \u4e2a\u4f53\u7684\u4ee3\u8c22\u7269\u7f51\u7edc\u5728\u62d3\u6251\u4e0a\u7b49\u540c\u4e8e\u5065\u5eb7\u4e2a\u4f53\u7684\u4ee3\u8c22\u7269\u7f51\u7edc\uff0c\u53ef\u4ee5\u8bbe\u8ba1\u53ef\u4ee5\u52a0\u5f3a N6-\u4e59\u9170\u8d56\u6c28\u9178\u548c\u7532\u57fa\u54aa\u5511\u4e4b\u95f4\u7684\u62ee\u6297\u4f5c\u7528\u7684\u6cbb\u7597\u5e72\u9884\uff0c\u4ece\u800c\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u5176\u5bf9\u4e9a\u6cb9\u9178\u7684\u6291\u5236\u4f5c\u7528\u3002\u8fd9\u8bf4\u660e\u4e86\u8be5\u7814\u7a76\u5bf9\u76f8\u5173\u836f\u7269\u7814\u53d1\u7684\u5e2e\u52a9\u3002<\/span><\/o:p><\/section>\n

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\u56fe4 \u5065\u5eb7\u4e0eIBD\u60a3\u8005\u4ee3\u8c22\u7f51\u7edc\u62d3\u6251\u7ed3\u6784\u5bf9\u6bd4\u7684\u8be6\u7ec6\u56fe\uff0c\u5256\u6790\u7684\u91cd\u70b9\u662f M3\u7684\u7ec6\u7c92\u5ea6\u7f51\u7edc\u7684\u57fa\u7840\u4e0a\u7684\u8d1f\u9762\u4ea4\u4e92\u4f5c\u7528<\/span><\/o:p><\/p>\n


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5. \u603b\u7ed3<\/strong><\/strong><\/strong><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n
 <\/span><\/section>\n
\u8be5\u7814\u7a76\u5f00\u521b\u6027\u5730\u5f00\u53d1\u5e76\u5e94\u7528\u7edf\u8ba1\u7269\u7406\u6a21\u578b\u6765\u5206\u6790\u5355\u4e00\u65f6\u95f4\u70b9\u7684\u4ee3\u8c22\u6570\u636e\uff0c\u901a\u8fc7\u5047\u8bbe\u4ee3\u8c22\u7269\u95f4\u8fbe\u6210\u8fdb\u5316\u7a33\u5b9a\u7b56\u7565<\/span>\uff08ESS\uff09<\/span>\uff0c\u6784\u5efa\u4ee3\u8c22\u7f51\u7edc\uff0c\u518d\u901a\u8fc7\u7f51\u7edc\u7c97\u7c92\u5316\u548cGLMY\u540c\u8c03\u6027\u5206\u6790\u5176\u62d3\u6251\u7ed3\u6784\u7684\u5dee\u5f02\uff0c\u53d1\u73b0\u7f51\u7edc\u540c\u8c03\u6027\u53ef\u4ee5\u5f88\u597d\u5730\u8868\u5f81\u5065\u5eb7\u5bf9\u7167\u7ec4\u6210\u7f51\u7edc\u548cIDB\u60a3\u8005\u7ec4\u6210\u7f51\u7edc\u4e4b\u95f4\u7684\u5dee\u5f02\uff0c\u4ee5\u53ca UC \u7f51\u7edc\u548c CD \u7f51\u7edc\u4e4b\u95f4\u7684\u5dee\u5f02\uff0c\u5e76\u5b9a\u4f4d\u5173\u952e\u4ee3\u8c22\u7269\u3002<\/span><\/o:p><\/section>\n

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\u8be5\u7814\u7a76\u4e3a\u5b9e\u73b0\u590d\u6742\u7f51\u7edc\u7406\u8bba\u5256\u6790\u590d\u6742\u75be\u75c5\u7684\u673a\u5236\u57fa\u7840\u63d0\u4f9b\u4e86\u4e00\u4e2a\u8d77\u70b9\u3002\u672a\u6765\u7684\u6539\u8fdb\u6709\u5f88\u591a\u65b9\u9762\uff0c\u5305\u62ec\u5f15\u5165\u66f4\u591a\u6765\u6e90\u7684\u6570\u636e\uff0c\u4f8b\u5982\u5fae\u751f\u7269\u7ec4\u3001\u8f6c\u5f55\u7ec4\u3001\u86cb\u767d\u7ec4\u4e0e\u8868\u578b\u7ec4\uff0c\u5728\u66f4\u591a\u7a7a\u95f4\u5c3a\u5ea6\u4e0a\u8ba8\u8bba\u4f17\u591a\u56e0\u7d20\u5982\u4f55\u4ecb\u5bfc\u590d\u6742\u75be\u75c5\u7684\u53d1\u751f\u3002\u53e6\u4e00\u4e2a\u65b9\u5411\u662f\u5f15\u5165\u76f8\u6bd4Lokta\u2013Volterra\u6a21\u578b\u66f4\u4e3a\u771f\u5b9e\u7684\u751f\u6001\u5b66\u5047\u8bbe\uff0c\u4f8b\u5982\u8003\u8651\u4ee3\u8c22\u7269\u95f4\u7684\u5171\u751f\u4e0e\u7ade\u4e89\u3002\u8be5\u7814\u7a76\u7684\u6846\u67b6\u8fd8\u53ef\u80fd\u5728\u5206\u6790\u540c\u4e00\u4e2a\u4f53\u4e2d\u53d1\u751f\u7684\u591a\u79cd\u75be\u75c5\u7684\u5171\u540c\u75c5\u56e0\uff0c\u4ee5\u53ca\u540c\u65f6\u8bbe\u8ba1\u591a\u79cd\u5e38\u89c1\u75be\u75c5\u7684\u4e2a\u6027\u5316\u9884\u9632\u7b56\u7565\u66f4\u6709\u524d\u666f\u7684\u5e94\u7528\u3002<\/span><\/o:p><\/section>\n

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\u751f\u547d\u590d\u6742\u6027\u7cfb\u5217\u8bfb\u4e66\u4f1a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u751f\u547d\u662f\u4ec0\u4e48\uff1f\u751f\u547d\u600e\u6837\u8d77\u6e90\uff1f\u751f\u547d\u600e\u6837\u6f14\u5316\uff1f\u8fd9\u4e9b\u662f\u5bf9\u751f\u547d\u73b0\u8c61\u7684\u672c\u8d28\u8ffd\u95ee\uff0c\u9664\u4e86\u4f20\u7edf\u7684\u751f\u7269\u5b66\u7814\u7a76\uff0c\u5982\u4eca\u6709\u5927\u91cf\u6765\u81ea\u4fe1\u606f\u3001\u7269\u7406\u3001\u8ba1\u7b97\u673a\u9886\u57df\u7684\u5de5\u5177\u65b9\u6cd5\uff0c\u6b63\u5728\u63ed\u5f00\u751f\u547d\u590d\u6742\u6027\u8c1c\u9898\u3002<\/span>\u57fa\u4e8e\u6b64\uff0c\u96c6\u667a\u4ff1\u4e50\u90e8\u7b56\u5212\u201c\u751f\u547d\u590d\u6742\u6027\u201d\u7cfb\u5217\u8bfb\u4e66\u4f1a\uff0c\u81ea2020\u5e7411\u67085\u65e5\u81f3\u4eca\uff0c\u8fd1\u767e\u540d\u5728\u4ece\u4e8b\u76f8\u5173\u95ee\u9898\u7814\u7a76\u7684\u8001\u5e08\u540c\u5b66\u6216\u611f\u5174\u8da3\u7684\u670b\u53cb\u53c2\u4e0e\u3002<\/span><\/span><\/p>\n


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<\/span><\/span><\/a><\/section>\n


<\/p>\n

\u4e86\u89e3\u8bfb\u4e66\u4f1a\u5177\u4f53\u89c4\u5219\u3001\u62a5\u540d\u8bfb\u4e66\u4f1a\u8bf7\u70b9\u51fb\u4e0b\u65b9\u6587\u7ae0\uff1a<\/span><\/p>\n

\u751f\u547d\u590d\u6742\u6027\u7cfb\u5217\u8bfb\u4e66\u4f1a\uff1a\u4ece\u4fe1\u606f\u548c\u7269\u7406\u89c6\u89d2\u63a2\u7d22\u751f\u547d\u7684\u5185\u5728\u903b\u8f91<\/a><\/span><\/strong><\/span><\/p>\n


<\/span>
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n

\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n

1. <\/strong>PNAS\u901f\u9012\uff1a\u590d\u6742\u75be\u75c5\u7684\u4ee3\u8c22\u7ec4\u7269\u7406\u5b66<\/a><\/strong><\/span><\/strong><\/strong><\/section>\n
2. <\/strong>Nat. Commun. \u901f\u9012\uff1a\u8fdb\u5316\u5982\u4f55\u5851\u9020\u4ee3\u8c22\u8868\u578b\uff1f\u8de8\u7269\u79cd\u4ee3\u8c22\u7f51\u7edc\u7684\u529f\u80fd\u6bd4\u8f83<\/a><\/strong><\/span><\/strong><\/strong><\/section>\n
3.<\/strong> Nat. Mach. Intell. \u901f\u9012\uff1a\u5229\u7528\u795e\u7ecf\u5e38\u5fae\u5206\u65b9\u7a0b\u9884\u6d4b\u5fae\u751f\u7269\u7fa4\u843d\u4ee3\u8c22\u8c31<\/a><\/strong><\/span><\/section>\n
4. <\/strong><\/strong><\/span>\u5f20\u6c5f\uff1a\u7b2c\u4e09\u4ee3\u4eba\u5de5\u667a\u80fd\u6280\u672f\u57fa\u7840\u2014\u2014\u4ece\u53ef\u5fae\u5206\u7f16\u7a0b\u5230\u56e0\u679c\u63a8\u7406 | \u96c6\u667a\u5b66\u56ed\u5168\u65b0\u8bfe\u7a0b<\/a><\/strong><\/strong><\/span><\/section>\n
5. \u6210\u4e3a\u96c6\u667aVIP\uff0c\u89e3\u9501\u5168\u7ad9\u8bfe\u7a0b\uff0f\u8bfb\u4e66\u4f1a<\/a><\/span><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/section>\n
6. <\/strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/span><\/a><\/section>\n


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