{"id":46496,"date":"2023-11-15T16:43:19","date_gmt":"2023-11-15T08:43:19","guid":{"rendered":"https:\/\/swarma.org\/?p=46496"},"modified":"2023-11-15T16:43:19","modified_gmt":"2023-11-15T08:43:19","slug":"barabasi-%e7%bb%84%e6%96%b0%e4%bd%9c%ef%bc%9a%e9%9d%9e%e7%bc%96%e7%a0%81-rna-%e6%8f%90%e9%ab%98%e7%bd%91%e7%bb%9c%e5%8c%bb%e5%ad%a6%e9%a2%84%e6%b5%8b%e8%83%bd%e5%8a%9b","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=46496","title":{"rendered":"Barabasi \u7ec4\u65b0\u4f5c\uff1a\u975e\u7f16\u7801 RNA \u63d0\u9ad8\u7f51\u7edc\u533b\u5b66\u9884\u6d4b\u80fd\u529b"},"content":{"rendered":"
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\u5173\u952e\u8bcd\uff1a\u590d\u6742\u7f51\u7edc\uff0c\u751f\u7269\u7f51\u7edc\uff0c\u7f51\u7edc\u533b\u5b66\uff0c\u76f8\u4e92\u4f5c\u7528\u7ec4<\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/p>\n<\/section>\n

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\u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
Noncoding RNAs improve the predictive power of network medicine<\/span><\/section>\n
\u8bba\u6587\u5730\u5740\uff1a<\/span><\/section>\n
https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2301342120<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n
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\u7f51\u7edc\u533b\u5b66\u63d0\u9ad8\u4e86\u4eba\u4eec\u5bf9\u75be\u75c5\u673a\u7406\u7684\u8ba4\u8bc6\uff0c\u63d0\u4f9b\u4e86\u5bf9\u75be\u75c5\u673a\u7406\u3001\u5408\u5e76\u75c7\u4ee5\u53ca\u65b0\u578b\u8bca\u65ad\u5de5\u5177\u548c\u6cbb\u7597\u65b9\u6cd5\u7684\u5b9a\u91cf\u89c1\u89e3\u3002\u7136\u800c\uff0c\u5927\u591a\u6570\u57fa\u4e8e\u7f51\u7edc\u7684\u65b9\u6cd5\u90fd\u4f9d\u8d56\u4e8e\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528<\/span>\uff08PPI\uff09<\/span>\u7684\u7efc\u5408\u56fe\u8c31\uff0c\u800c\u5ffd\u7565\u4e86\u975e\u7f16\u7801 RNA<\/span>\uff08ncRNA\uff09<\/span>\u4ecb\u5bfc\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u5df4\u62c9\u5df4\u897f\u7ec4\u8fd1\u65e5\u4e8ePNAS<\/em>\u4e0a\u53d1\u8868\u7684\u5b9e\u8bc1\u7814\u7a76\uff0c\u7cfb\u7edf\u6027\u5730\u5c06\u975e\u7f16\u7801RNA\u4e0e\u86cb\u767d\u8d28\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u7ed3\u5408\u8d77\u6765\uff0c\u6784\u5efa\u4e86\u4e00\u4e2a\u5305\u542b\u4eba\u4f53\u7ec6\u80de\u4e2d\u6240\u6709\u7269\u7406\u76f8\u4e92\u4f5c\u7528\u7684\u7efc\u5408\u7f51\u7edc<\/strong>\u3002<\/span><\/section>\n

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\u52a0\u5165\u975e\u7f16\u7801RNA\u589e\u52a0\u4e86\u76f8\u4e92\u4f5c\u7528\u7ec4\u4e2d\u57fa\u56e0\u548c\u76f8\u4e92\u4f5c\u7528\u7684\u6570\u91cf\uff0c\u76f8\u4e92\u4f5c\u7528\u7ec4\u4e2d\u7684\u57fa\u56e0\u6570\u91cf\u589e\u52a0\u4e86 46%\uff0c\u76f8\u4e92\u4f5c\u7528\u7684\u6570\u91cf\u589e\u52a0\u4e86 107%\uff0c\u53d1\u73b0\u4e86 132 \u79cd\u75be\u75c5\u6a21\u5757\uff0c\u5b83\u4eec\u5728\u57fa\u4e8e\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7ec4\u4e2d\u7f3a\u4e4f\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u4f46\u5728\u7eb3\u5165\u975e\u7f16\u7801RNA\u4ecb\u5bfc\u7684\u76f8\u4e92\u4f5c\u7528\u540e\u5374\u6709\u4e86\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u8fd9\u5927\u5927\u63d0\u9ad8\u4e86\u7f51\u7edc\u79d1\u5b66\u8bc6\u522b\u75be\u75c5\u6a21\u5757\u7684\u80fd\u529b\u3002\u8fd9\u9879\u7814\u7a76\u6700\u7ec8\u8868\u660e\uff0c\u7eb3\u5165\u975e\u7f16\u7801RNA\u76f8\u4e92\u4f5c\u7528\u6709\u52a9\u4e8e\u63ed\u793a\u4ee5\u524d\u65e0\u6cd5\u68c0\u6d4b\u5230\u7684\u75be\u75c5\u95f4\u5173\u7cfb\uff0c\u5e76\u63d0\u9ad8\u6211\u4eec\u9884\u6d4b\u75be\u75c5\u95f4\u5171\u75c5\u6a21\u5f0f\u7684\u51c6\u786e\u6027\u3002<\/span><\/section>\n

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\u56fe1. ncRNA \u5728\u57fa\u56e0\u8c03\u63a7\u4e2d\u7684\u4f5c\u7528\u4ee5\u53ca\u4e0e\u4eba\u7c7b\u76f8\u4e92\u4f5c\u7528\u7ec4\u7684\u8054\u7cfb\u3002(A) <\/span>\u73b0\u4ee3\u751f\u7269\u5b66\u7684\u4e2d\u5fc3\u6cd5\u5219\u3002\u663e\u793a\u8f6c\u5f55\u8fc7\u7a0b\u7684 DNA \u94fe\uff1amiRNA\u3001lncRNA \u548c mRNA \u90fd\u662f\u4ece DNA \u8f6c\u5f55\u7684\uff1b\u7136\u800c\uff0c\u53ea\u6709\u7ecf\u8fc7\u5904\u7406\u7684 mRNA \u624d\u80fd\u7ffb\u8bd1\u6210\u86cb\u767d\u8d28\u3002(B) <\/span>miRNA \u53ef\u4e0e lncRNA\u3001mRNA \u548c\u86cb\u767d\u8d28\u7ed3\u5408\u3002\u5f53 miRNA \u4e0e mRNA \u548c lncRNA \u76f8\u4e92\u4f5c\u7528\u65f6\uff0c\u5b83\u4eec\u4f1a\uff08\u6fc0\u6d3b\u6216\u6291\u5236\uff09\u57fa\u56e0\u8868\u8fbe\u8fc7\u7a0b\u3002(C) \u86cb\u767d\u8d28\u4e92\u4f5c\u7f51\u7edc\u3002\u86cb\u767d\u8d28\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\uff0c\u5f62\u6210\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u3002\u6709\u4e9b\u86cb\u767d\u8d28\u5145\u5f53 \u8f6c\u5f55\u56e0\u5b50\uff0c\u8c03\u63a7\u57fa\u56e0\u8868\u8fbe\u3002\u86cb\u767d\u8d28\u4e92\u4f5c\u7f51\u7edc\u53ea\u6d89\u53ca\u86cb\u767d\u7f16\u7801\u57fa\u56e0\u4e4b\u95f4\u7684\u7ed3\u5408\u76f8\u4e92\u4f5c\u7528\u3002(D<\/span>)\u975e\u7f16\u7801RNA\u4e0e\u86cb\u767d\u7f16\u7801 RNA \u76f8\u4e92\u4f5c\u7528\uff0c\u5f62\u6210\u4e00\u4e2a\u8fde\u63a5\u5bc6\u96c6\u7684\u7f51\u7edc\uff0c\u5373\u86cb\u767d\u8d28\u4e92\u4f5c\u7f51\u7edc\u548c\u975e\u7f16\u7801RNA\u4e92\u4f5c\u7f51\u7edc\uff0c\u5176\u4e2d\u5305\u542b\u6765\u81ea\u4e0d\u540c\u57fa\u56e0\u7ec4\u5143\u7d20\u7684\u591a\u79cd\u7c7b\u578b\u7684\u7269\u7406\u76f8\u4e92\u4f5c\u7528\u3002(E) \u86cb\u767d\u8d28\u4e92\u4f5c\u7f51\u7edc\u548c\u975e\u7f16\u7801RNA\u4e92\u4f5c\u7f51\u7edc\u3002\u7f51\u7edc\u4e0a\u7684\u6bcf\u6761\u8fb9\u4ee3\u8868\u4e0d\u540c\u5143\u7d20\u7c7b\u578b\u4e4b\u95f4\u5404\u81ea\u76f8\u4e92\u4f5c\u7528\u7684\u76f8\u5bf9\u9891\u7387\u3002\u86cb\u767d\u8d28\u4e92\u4f5c\u7f51\u7edc\u662f\u86cb\u767d\u8d28\u4e92\u4f5c\u7f51\u7edc\u548c\u975e\u7f16\u7801RNA\u4e92\u4f5c\u7f51\u7edc\u7684\u4e00\u4e2a\u5b50\u56fe\uff0c\u5b83\u53ea\u5305\u542b\u86cb\u767d\u8d28\u7f16\u7801\u57fa\u56e0\u53ca\u5176\u76f8\u4e92\u4f5c\u7528\uff1b\u8f6c\u5f55\u56e0\u5b50\u548c\u86cb\u767d\u8d28\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u5360\u86cb\u767d\u8d28\u4e92\u4f5c\u7f51\u7edc\u548c\u975e\u7f16\u7801RNA\u4e92\u4f5c\u7f51\u7edc\u7f51\u7edc\u4e2d\u76f8\u4e92\u4f5c\u7528\u7684 33%\uff0c\u8fd9\u8868\u660e\u5c3d\u7ba1\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u5728\u7f51\u7edc\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u4f46\u5b83\u4eec\u4e0e\u5176\u4ed6\u7fa4\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\u4e5f\u5f88\u91cd\u8981\u3002\u5927\u591a\u6570\u76f8\u4e92\u4f5c\u7528\u53d1\u751f\u5728 miRNA \u4e0e\u86cb\u767d\u7f16\u7801\u57fa\u56e0\u548c\u8f6c\u5f55\u56e0\u5b50\u4e4b\u95f4\u3002<\/span><\/p>\n


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\u56fe2. \u5bf9\u6bd4\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u514b\u7f57\u6069\u75c5\u3001\u5148\u5146\u5b50\u75eb\u7684\u75be\u75c5\u6a21\u5757\u7f51\u7edc\u5728\u53ea\u5305\u542b\u86cb\u767d\u8d28\u4e92\u4f5c\uff08\u4e0a\u56fe\uff09\u548c\u5f15\u5165\u4e86\u975e\u7f16\u7801RNA\u540e\uff08\u4e0b\u56fe\uff09\u7684\u5bf9\u6bd4\uff0c\u5f15\u5165\u540e\u7f51\u7edc\u4e2d\u6d89\u53ca\u7684\u57fa\u56e0\u548c\u76f8\u4e92\u4f5c\u7528\u57fa\u56e0\u5bf9\u589e\u52a0<\/span><\/p>\n


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\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1a<\/strong><\/p>\n

AI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a\u542f\u52a8<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1aAI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a\u542f\u52a8<\/a><\/span>
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\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n<\/section>\n

\u200d<\/span>1. <\/strong>\u672a\u6765\u533b\u5b66\u5c55\u671b\uff1a\u591a\u5c3a\u5ea6\u751f\u547d\u5f62\u5f0f\u4e3a\u751f\u7269\u533b\u5b66\u63d0\u4f9b\u65b0\u9053\u8def<\/a><\/strong><\/span><\/strong><\/strong><\/section>\n
2.<\/strong> \u8001\u836f\u65b0\u7528\u6cbb\u7597\u65b0\u51a0\u75be\u75c5\uff1f\u7f51\u7edc\u533b\u5b66\u6846\u67b6\u52a0\u901f\u836f\u7269\u7814\u53d1<\/a><\/strong><\/span><\/strong><\/section>\n
3.<\/strong><\/strong> \u7f51\u7edc\u533b\u5b66\u65b0\u53d1\u73b0\uff1a\u897f\u5730\u90a3\u975e\u5177\u6709\u9632\u6cbb\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u6f5c\u529b<\/a><\/strong><\/strong><\/span><\/section>\n
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4. <\/strong><\/strong><\/span>\u5f20\u6c5f\uff1a\u7b2c\u4e09\u4ee3\u4eba\u5de5\u667a\u80fd\u6280\u672f\u57fa\u7840\u2014\u2014\u4ece\u53ef\u5fae\u5206\u7f16\u7a0b\u5230\u56e0\u679c\u63a8\u7406 | \u96c6\u667a\u5b66\u56ed\u5168\u65b0\u8bfe\u7a0b<\/a><\/strong><\/strong><\/span><\/section>\n
5. <\/strong><\/strong>\u6210\u4e3a\u96c6\u667aVIP\uff0c\u89e3\u9501\u5168\u7ad9\u8bfe\u7a0b\uff0f\u8bfb\u4e66\u4f1a<\/a><\/span><\/strong><\/strong><\/strong><\/section>\n
6. <\/strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/span><\/a><\/section>\n

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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/strong><\/span><\/strong><\/section>\n

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\u5173\u952e\u8bcd\uff1a\u590d\u6742\u7f51\u7edc\uff0c\u751f\u7269\u7f51\u7edc\uff0c\u7f51\u7edc\u533b\u5b66\uff0c\u76f8\u4e92\u4f5c\u7528\u7ec4 \u8bba\u6587\u9898\u76ee\uff1a Noncoding RNAs improve the predictive power of network medicine \u8bba\u6587\u5730\u5740\uff1a https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2301342120 …<\/p>\n","protected":false},"author":0,"featured_media":46491,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/46496"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=46496"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/46496\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/46491"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=46496"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=46496"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=46496"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=46496"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}