{"id":46598,"date":"2023-11-19T17:30:48","date_gmt":"2023-11-19T09:30:48","guid":{"rendered":"https:\/\/swarma.org\/?p=46598"},"modified":"2023-11-19T17:30:48","modified_gmt":"2023-11-19T09:30:48","slug":"prl%e9%80%9f%e9%80%92%ef%bc%9a%e8%b0%83%e8%8a%82%e7%94%9f%e7%89%a9%e6%8c%af%e8%8d%a1%ef%bc%8c%e5%88%a9%e7%94%a8%e9%9d%9e%e7%ba%bf%e6%80%a7%e5%8a%a8%e5%8a%9b%e5%ad%a6%e8%a7%a3%e8%80%a6%e9%a2%91","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=46598","title":{"rendered":"PRL\u901f\u9012\uff1a\u8c03\u8282\u751f\u7269\u632f\u8361\uff0c\u5229\u7528\u975e\u7ebf\u6027\u52a8\u529b\u5b66\u89e3\u8026\u9891\u7387\u548c\u632f\u5e45\u7684\u666e\u9002\u6027\u7406\u8bba"},"content":{"rendered":"
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\u8fd1\u65e5\uff0c\u590d\u65e6\u5927\u5b66\u667a\u80fd\u590d\u6742\u4f53\u7cfb\u57fa\u7840\u7406\u8bba\u4e0e\u5173\u952e\u6280\u672f\u5b9e\u9a8c\u5ba4\u6797\u4f1f\u3001\u79e6\u4f2f\u97e1\u8bfe\u9898\u7ec4\u4ee5\u201cModulating Biological Rhythms: A Noncomputational Strategy Harnessing Nonlinearity and Decoupling Frequency and Amplitude\u201d\u4e3a\u9898\u4e8ePhysical Review Letters\u5728\u7ebf\u53d1\u8868\u4e86\u7814\u7a76\u8bba\u6587\u3002\u8be5\u5de5\u4f5c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u63ed\u793a\u4e86\u89e3\u8026\u751f\u7269\u632f\u8361\u9891\u7387\u548c\u632f\u5e45\u7684\u666e\u9002\u6027\u7406\u8bba\uff0c\u5e76\u5728\u6b64\u57fa\u7840\u4e0a\u63d0\u51fa\u4e86\u6613\u7528\u9ad8\u6548\u7684\u8c03\u9891\u8c03\u5e45\u63a7\u5236\u5668\u8bbe\u8ba1\u65b9\u6cd5\u3002\u8fd9\u4e00\u7814\u7a76\u5de5\u4f5c\u4e0d\u4ec5\u4e3a\u751f\u7269\u632f\u8361\u7cfb\u7edf\u7684\u8c03\u9891\u8c03\u5e45\u5efa\u7acb\u4e86\u76f8\u5bf9\u5b8c\u5907\u7684\u6570\u7406\u57fa\u7840\uff0c\u9891\u7387\u3001\u632f\u5e45\u89e3\u8026\u539f\u7406\u7684\u63ed\u793a\u4e5f\u4e3a\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u52a9\u529b\u751f\u7269\u5b66\u5bb6\u5b9e\u73b0\u5408\u6210\u751f\u547d\u7cfb\u7edf\u7684\u8c03\u9891\u8c03\u5e45\u63d0\u4f9b\u4e86\u539f\u7406\u6307\u5f15\u3002<\/span><\/strong><\/span><\/strong><\/section>\n
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\u8bba\u6587\u9898\u76ee\uff1a<\/span><\/section>\n
Modulating Biological Rhythms: A Noncomputational Strategy Harnessing Nonlinearity and Decoupling Frequency and Amplitude<\/span><\/section>\n
\u8bba\u6587\u5730\u5740\uff1a <\/span><\/section>\n
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\u56fe 3 \u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u4ea4\u4e92\u7cfb\u7edf\u4e2d\u7684\u86cb\u767d\u8d28\u6d53\u5ea6\u632f\u5e45\u8c03\u63a7\u3002<\/span><\/p>\n


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\u8fd9\u4e00\u7814\u7a76\u5de5\u4f5c\u4e0d\u4ec5\u4e3a\u751f\u7269\u632f\u8361\u7cfb\u7edf\u7684\u8c03\u9891\u8c03\u5e45\u5efa\u7acb\u4e86\u76f8\u5bf9\u5b8c\u5907\u7684\u6570\u7406\u57fa\u7840\uff0c\u9891\u7387\u3001\u632f\u5e45\u89e3\u8026\u539f\u7406\u7684\u63ed\u793a\u4e5f\u4e3a\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u52a9\u529b\u751f\u7269\u5b66\u5bb6\u5b9e\u73b0\u5408\u6210\u751f\u7269\u7cfb\u7edf\u7684\u8c03\u9891\u8c03\u5e45\u63d0\u4f9b\u4e86\u539f\u7406\u6307\u5f15\u3002\u8be5\u5de5\u4f5c\u662f\u590d\u65e6\u56e2\u961f\u5728\u8fc7\u53bb\u5341\u5e74\u4e8e\u201c\u751f\u7269\u632f\u8361\u8c03\u9891\u8c03\u5e45\u57fa\u7840\u7406\u8bba\u4e0e\u5173\u952e\u7b97\u6cd5\u201d\u8fd9\u4e00\u9886\u57df\u7684\u7cfb\u5217\u6210\u679c\u4e4b\u4e00[8,9,10]\u3002\u590d\u65e6\u5927\u5b66\u6570\u5b66\u79d1\u5b66\u5b66\u9662\u3001\u667a\u80fd\u590d\u6742\u4f53\u7cfb\u57fa\u7840\u7406\u8bba\u4e0e\u5173\u952e\u6280\u672f\u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u751f\u4ef2\u662d\u6708\u4e3a\u8bba\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\uff0c\u6797\u4f1f\u6559\u6388\u3001\u79e6\u4f2f\u97e1\u526f\u7814\u7a76\u5458\u4e3a\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002\u672c\u7814\u7a76\u5f97\u5230\u4e86\u79d1\u6280\u521b\u65b02030\u2014\u201c\u8111\u79d1\u5b66\u4e0e\u7c7b\u8111\u7814\u7a76\u201d\u91cd\u5927\u9879\u76ee\u3001\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u4e0a\u6d77\u5e02\u79d1\u5b66\u6280\u672f\u59d4\u5458\u4f1a\u3001\u4e0a\u6d77\u5e02\u6559\u80b2\u59d4\u5458\u4f1a\u548c\u4e0a\u6d77\u4eba\u5de5\u667a\u80fd\u5b9e\u9a8c\u5ba4\u7684\u652f\u6301\u3002<\/span><\/p>\n


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\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/span><\/p>\n

1.Zhen Zhou, Yuting Liu, Yushen Feng, Stephen Klepin, Lev S. Tsimring, Lorraine Pillus, Jeff Hasty, and Nan Hao, Engineering longevity-design of a synthetic gene oscillator to slow cellular aging, Science<\/em>, 380, 376-381 (2023).<\/span><\/p>\n

2.A.S. Hansen, and E.K. O\u2019Shea, Limits on information transduction through amplitude and frequency regulation of transcription factor activity, eLife<\/em> 4, e06559 (2015).<\/span><\/p>\n

3.J. Bass, and J.S. Takahashi, Circadian integration of metabolism and energetics, Science<\/em> 330, 1349-1354 (2010).<\/span><\/p>\n

4.F. Rijo-Ferreira, and J.S. Takahashi, Genomics of circadian rhythms in health and disease, Genome Med.<\/em> 11, 82 (2019).<\/span><\/p>\n

5.T.Y.-C. Tsai, Y.S. Choi, W. Ma, J.R. Pomerening, C. Tang, and J.E. Ferrell, Robust, tunable biological oscillations from interlinked positive and negative feedback loops, Science<\/em> 321, 126-129 (2008).<\/span><\/p>\n

6.M. Tomazou, M. Barahona, K.M. Polizzi, and G.-B. Stan, <\/em>Computational re-design of synthetic genetic oscillators for independent amplitude and frequency modulation. Cell Syst.<\/em> 6, 508-520.e5 (2018).<\/span><\/p>\n

7.F. Zhang, Y. Sun, Y. Zhang et al.<\/em>, Independent control of amplitude and period in a synthetic oscillator circuit with modified repressilator, Commun. Biol.<\/em> 5, 23 (2022).<\/span><\/p>\n

8.T. Ge, X. Tian, J. Kurths, J. Feng, and W. Lin, Achieving modulated oscillations by feedback control, Phys. Rev. E<\/em> 90, 022909 (2014).<\/span><\/p>\n

9.B.-W. Qin, L. Zhao, and W. Lin, A frequency-amplitude coordinator and its optimal energy consumption for biological oscillators, Nat. Commun.<\/em> 12, 5894 (2021).<\/span><\/p>\n

10.Z. Zhong, W. Lin, and B.-W. Qin, Modulating biological rhythms: A noncomputational strategy harnessing nonlinearity and decoupling frequency and amplitude, Phys. Rev. Lett.<\/em> 131, 138401 (2023).<\/span><\/p>\n


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\u751f\u547d\u590d\u6742\u6027\u7cfb\u5217\u8bfb\u4e66\u4f1a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u751f\u547d\u662f\u4ec0\u4e48\uff1f\u751f\u547d\u600e\u6837\u8d77\u6e90\uff1f\u751f\u547d\u600e\u6837\u6f14\u5316\uff1f\u8fd9\u4e9b\u662f\u5bf9\u751f\u547d\u73b0\u8c61\u7684\u672c\u8d28\u8ffd\u95ee\uff0c\u9664\u4e86\u4f20\u7edf\u7684\u751f\u7269\u5b66\u7814\u7a76\uff0c\u5982\u4eca\u6709\u5927\u91cf\u6765\u81ea\u4fe1\u606f\u3001\u7269\u7406\u3001\u8ba1\u7b97\u673a\u9886\u57df\u7684\u5de5\u5177\u65b9\u6cd5\uff0c\u6b63\u5728\u63ed\u5f00\u751f\u547d\u590d\u6742\u6027\u8c1c\u9898\u3002<\/span>\u57fa\u4e8e\u6b64\uff0c\u96c6\u667a\u4ff1\u4e50\u90e8\u7b56\u5212\u201c\u751f\u547d\u590d\u6742\u6027\u201d\u7cfb\u5217\u8bfb\u4e66\u4f1a\uff0c\u81ea2020\u5e7411\u67085\u65e5\u81f3\u4eca\uff0c\u8fd1\u767e\u540d\u5728\u4ece\u4e8b\u76f8\u5173\u95ee\u9898\u7814\u7a76\u7684\u8001\u5e08\u540c\u5b66\u6216\u611f\u5174\u8da3\u7684\u670b\u53cb\u53c2\u4e0e\u3002<\/span><\/span><\/p>\n


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\u4e86\u89e3\u8bfb\u4e66\u4f1a\u5177\u4f53\u89c4\u5219\u3001\u62a5\u540d\u8bfb\u4e66\u4f1a\u8bf7\u70b9\u51fb\u4e0b\u65b9\u6587\u7ae0\uff1a<\/span><\/p>\n

\u751f\u547d\u590d\u6742\u6027\u7cfb\u5217\u8bfb\u4e66\u4f1a\uff1a\u4ece\u4fe1\u606f\u548c\u7269\u7406\u89c6\u89d2\u63a2\u7d22\u751f\u547d\u7684\u5185\u5728\u903b\u8f91<\/a><\/span><\/strong><\/span><\/p>\n


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1. <\/strong>\u672a\u6765\u533b\u5b66\u5c55\u671b\uff1a\u591a\u5c3a\u5ea6\u751f\u547d\u5f62\u5f0f\u4e3a\u751f\u7269\u533b\u5b66\u63d0\u4f9b\u65b0\u9053\u8def<\/a><\/strong><\/span><\/strong><\/section>\n
2.<\/strong> \u81ea\u9002\u5e94\u4f0a\u8f9b\u6a21\u578b\uff0c\u89e3\u91ca\u5927\u8111\u4e2d\u96ea\u5d29\u548c\u632f\u8361\u5982\u4f55\u5728\u4e34\u754c\u70b9\u5171\u5b58<\/a><\/strong><\/span><\/strong><\/section>\n
3.<\/strong> \u590d\u6742\u7f51\u7edc\u4e2d\u7684\u52a8\u529b\u5b66\u73b0\u8c61\uff1a\u57fa\u7840\u4e0e\u5e94\u7528<\/a><\/strong><\/strong><\/span><\/section>\n
4. <\/strong><\/strong><\/span>\u5f20\u6c5f\uff1a\u7b2c\u4e09\u4ee3\u4eba\u5de5\u667a\u80fd\u6280\u672f\u57fa\u7840\u2014\u2014\u4ece\u53ef\u5fae\u5206\u7f16\u7a0b\u5230\u56e0\u679c\u63a8\u7406 | \u96c6\u667a\u5b66\u56ed\u5168\u65b0\u8bfe\u7a0b<\/a><\/strong><\/strong><\/span><\/section>\n
5. \u6210\u4e3a\u96c6\u667aVIP\uff0c\u89e3\u9501\u5168\u7ad9\u8bfe\u7a0b\uff0f\u8bfb\u4e66\u4f1a<\/a><\/span><\/strong><\/strong><\/strong><\/section>\n
6. <\/strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/span><\/a><\/section>\n


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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/span><\/strong><\/section>\n

<\/mp-style-type><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bfc\u8bed \u8fd1\u65e5\uff0c\u590d\u65e6\u5927\u5b66\u667a\u80fd\u590d\u6742\u4f53\u7cfb\u57fa\u7840\u7406\u8bba\u4e0e\u5173\u952e\u6280\u672f\u5b9e\u9a8c\u5ba4\u6797\u4f1f\u3001\u79e6\u4f2f\u97e1\u8bfe\u9898\u7ec4\u4ee5\u201cModulating Biological Rhythms: A Noncomputational Strategy Harnessing Nonlinearity and Decoupling Frequency and…<\/p>\n","protected":false},"author":0,"featured_media":46591,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/46598"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=46598"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/46598\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/46591"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=46598"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=46598"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=46598"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=46598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}