{"id":47029,"date":"2023-12-08T16:44:04","date_gmt":"2023-12-08T08:44:04","guid":{"rendered":"https:\/\/swarma.org\/?p=47029"},"modified":"2023-12-08T16:44:04","modified_gmt":"2023-12-08T08:44:04","slug":"nat-commun-%e9%80%9f%e9%80%92%ef%bc%9a%e5%88%a9%e7%94%a8%e6%b7%b1%e5%ba%a6%e7%94%9f%e6%88%90%e6%a8%a1%e5%9e%8bspatialscope%e6%95%b4%e5%90%88%e7%a9%ba%e9%97%b4%e5%92%8c%e5%8d%95%e7%bb%86%e8%83%9e","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=47029","title":{"rendered":"Nat. Commun.\u901f\u9012\uff1a\u5229\u7528\u6df1\u5ea6\u751f\u6210\u6a21\u578bSpatialScope\u6574\u5408\u7a7a\u95f4\u548c\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e"},"content":{"rendered":"
\n
\n
\n
\n

<\/p>\n


<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/p>\n

\u5173\u952e\u8bcd\uff1a\u6df1\u5ea6\u751f\u6210\u6a21\u578b\uff0c\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\uff0c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\uff0c\u6570\u636e\u6574\u5408<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/p>\n


<\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/p>\n<\/section>\n

\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
\n


<\/p>\n

<\/p>\n<\/section>\n

\n
\n
\n
\n
\u8bba\u6587\u9898\u76ee\uff1a\uff1aIntegrating spatial and single-cell transcriptomics data using deep generative models with SpatialScope<\/span><\/section>\n
\u8bba\u6587\u671f\u520a\uff1aNature Communications<\/em><\/span><\/section>\n
\u8bba\u6587\u5730\u5740\uff1ahttps:\/\/www.nature.com\/articles\/s41467-023-43629-w<\/span><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/blockquote>\n

<\/section>\n
\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66<\/span>\uff08spatial transcriptomics\uff0cST\uff09<\/span>\u6280\u672f\u7684\u8fc5\u901f\u5174\u8d77\uff0c\u6b63\u5728\u5f7b\u5e95\u6539\u53d8\u6211\u4eec\u5bf9\u751f\u7269\u7ec4\u7ec7\u7684\u7a7a\u95f4\u7ed3\u6784\u548c\u751f\u7269\u5b66\u529f\u80fd\u7684\u8ba4\u8bc6\u3002\u5c3d\u7ba1\u76ee\u524d\u7684\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u65b9\u6cd5\uff0c\u65e0\u8bba\u662f\u57fa\u4e8e\u7b2c\u4e8c\u4ee3\u6d4b\u5e8f<\/span>\uff08\u57fa\u4e8e\u5e8f\u5217\u7684\u65b9\u6cd5\uff09<\/span>\u8fd8\u662f\u8367\u5149\u539f\u4f4d\u6742\u4ea4<\/span>\uff08\u57fa\u4e8e\u56fe\u50cf\u7684\u65b9\u6cd5\uff09<\/span>\uff0c\u90fd\u80fd\u63d0\u4f9b\u6709\u4ef7\u503c\u7684\u89c1\u89e3\uff0c\u4f46\u5b83\u4eec\u5728\u7ec6\u80de\u5206\u8fa8\u7387\u6216\u8f6c\u5f55\u7ec4\u8303\u56f4\u7684\u5256\u6790\u65b9\u9762\u90fd\u9762\u4e34\u7740\u5c40\u9650\u6027\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e9b\u5c40\u9650\u6027\uff0c\u8fd9\u9879\u7814\u7a76\u63d0\u51fa SpatialScope\uff0c\u4e00\u79cd\u5229\u7528\u6df1\u5ea6\u751f\u6210\u6a21\u578b\u6574\u5408\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\u548c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u7684\u901a\u7528\u65b9\u6cd5\u3002\u901a\u8fc7\u5bf9\u6a21\u578b\u548c\u7b97\u6cd5\u8bbe\u8ba1\u7684\u521b\u65b0\uff0cSpatialScope\u4e0d\u4ec5\u589e\u5f3a\u4e86\u57fa\u4e8e\u5e8f\u5217\u7684\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u4ee5\u5b9e\u73b0\u5355\u7ec6\u80de\u5206\u8fa8\u7387\uff0c\u8fd8\u80fd\u51c6\u786e\u63a8\u65ad\u57fa\u4e8e\u56fe\u50cf\u7684\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u7684\u5168\u8f6c\u5f55\u7ec4\u8868\u8fbe\u6c34\u5e73\u3002\u7814\u7a76\u901a\u8fc7\u57fa\u4e8e\u5e8f\u5217\u548c\u57fa\u4e8e\u56fe\u50cf\u7684\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u65b9\u6cd5\u7684\u6a21\u62df\u7814\u7a76\u548c\u5b9e\u9645\u6570\u636e\u5206\u6790\uff0c\u8bc1\u660e\u4e86 SpatialScope \u7684\u5b9e\u7528\u6027\u3002SpatialScope \u80fd\u4ee5\u6574\u4e2a\u8f6c\u5f55\u7ec4\u7684\u5355\u7ec6\u80de\u5206\u8fa8\u7387\u63d0\u4f9b\u7ec4\u7ec7\u7ed3\u6784\u7684\u7a7a\u95f4\u7279\u5f81\uff0c\u4ece\u800c\u4fc3\u8fdb\u4e0b\u6e38\u5206\u6790\uff0c\u5305\u62ec\u901a\u8fc7\u914d\u4f53\u4e0e\u53d7\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\u68c0\u6d4b\u7ec6\u80de\u901a\u8baf\u3001\u5b9a\u4f4d\u7ec6\u80de\u4e9a\u578b\u4ee5\u53ca\u8bc6\u522b\u7a7a\u95f4\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u3002<\/span><\/section>\n

<\/span><\/section>\n
<\/section>\n

\u56fe1. SpatialScope \u65e8\u5728\u5229\u7528\u6df1\u5ea6\u751f\u6210\u6a21\u578b\u7684\u80fd\u529b\uff0c\u4ece\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u53c2\u8003\u6570\u636e\u4e2d\u5b66\u4e60\u8868\u8fbe\u91cf\u5206\u5e03\uff0c\u4ece\u800c\u63a8\u65ad\u7a7a\u95f4\u5206\u8fa8\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u3002SpatialScope \u7684\u5de5\u4f5c\u6d41\u7a0b\u9996\u5148\u662f\u91cf\u5316\u4f4e\u5206\u8fa8\u7387\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\uff08\u5982 Visium\uff09\u4e2d\u6bcf\u4e2a\u70b9\u5185\u7684\u7ec6\u80de\u6570\u91cf\u3002\u968f\u540e\uff0c\u5b83\u5c06\u786e\u5b9a\u70b9\u5185\u5355\u4e2a\u7ec6\u80de\u7684\u7ec6\u80de\u7c7b\u578b\u6807\u7b7e\u3002\u6700\u540e\uff0c\u4ee5\u63a8\u65ad\u51fa\u7684\u7ec6\u80de\u7c7b\u578b\u6807\u7b7e\u4e3a\u6761\u4ef6\uff0cSpatialScope \u8fdb\u884c\u57fa\u56e0\u8868\u8fbe\u5206\u89e3\uff0c\u5c06\u50cf\u7d20\u7ea7\u57fa\u56e0\u8868\u8fbe\u8c31\u8f6c\u5316\u4e3a\u5355\u7ec6\u80de\u7ea7\u5206\u8fa8\u7387\u3002\u901a\u8fc7\u8fd9\u79cd\u5206\u89e3\uff0c\u53ef\u4ee5\u5728\u5355\u7ec6\u80de\u6c34\u5e73\u4e0a\u8fdb\u884c\u66f4\u5168\u9762\u3001\u66f4\u7fd4\u5b9e\u7684\u4e0b\u6e38\u5206\u6790\u3002<\/span><\/p>\n


<\/section>\n

<\/p>\n

\u56fe2\uff1a\u57fa\u51c6\u6570\u636e\u96c6\u4e0b\u4e0d\u540c\u6570\u636e\u6574\u5408\u5de5\u5177\u7684\u7ed3\u679c\u63cf\u8ff0\u3002\u7a7a\u95f4\u6563\u70b9\u56fe\u663e\u793a\u4e86\u5355\u7ec6\u80de\u5206\u8fa8\u7387\u4e0b\u7684\u7ec6\u80de\u7c7b\u578b\u3002\u7ea2\u8272\u865a\u7ebf\u8868\u793a\u7ec6\u80de\u805a\u96c6\u4ea7\u751f\u7684\u7f51\u683c\u3002c \u67f1\u72b6\u56fe\u663e\u793a\u4e86\u56db\u79cd\u5355\u7247\u57fa\u51c6\u6570\u636e\u96c6\uff08\u6570\u636e\u96c6 1-4\uff09\u4e2d\u6bcf\u79cd\u65b9\u6cd5\u5728\u5355\u7ec6\u80de\u6c34\u5e73\u4e0a\u63a8\u65ad\u7ec6\u80de\u7c7b\u578b\u6807\u7b7e\u7684\u9519\u8bef\u7387\u3002d \u67f1\u72b6\u56fe\u663e\u793a\u4e86\u56db\u79cd\u5355\u7247\u57fa\u51c6\u6570\u636e\u96c6\uff08\u6570\u636e\u96c6 1-4\uff09\u4e2d\u6bcf\u79cd\u65b9\u6cd5\u5728\u70b9\u6c34\u5e73\u63a8\u65ad\u7ec6\u80de\u7c7b\u578b\u6bd4\u4f8b\u65f6\u7684\u76ae\u5c14\u68ee\u76f8\u5173\u7cfb\u6570\uff08PCC\uff09\u548c\u5747\u65b9\u6839\u8bef\u5dee\uff08RMSE\uff09\u3002e \u67f1\u72b6\u56fe\u663e\u793a\u4e86\u4e0d\u540c\u65b9\u6cd5\u5728\u4e0d\u540c\u6a21\u62df\u6355\u83b7\u7387\u4e0b\u63a8\u65ad\u56db\u4e2a\u5355\u5207\u7247\u57fa\u51c6\u6570\u636e\u96c6\uff08\u6570\u636e\u96c6 1-4\uff09\u4e2d\u6bcf\u4e2a\u5355\u7ec6\u80de\u5168\u8f6c\u5f55\u7ec4\u8868\u8fbe\u6c34\u5e73\u7684\u4f59\u5f26\u76f8\u4f3c\u5ea6\u3002<\/span><\/p>\n


<\/span><\/section>\n
<\/section>\n
\n

\u56fe3. SpatialScope \u80fd\u591f\u6574\u5408\u591a\u4e2a\u5207\u7247\uff0c\u5e76\u89e3\u91ca\u5c0f\u9f20\u5927\u8111\u76ae\u5c42\u6570\u636e\u4e2d\u7684\u7ec6\u80de\u95f4\u76f8\u4e92\u4f5c\u7528\u3002(a\uff0cb) 10x Visium\u5c0f\u9f20\u5927\u8111\u76ae\u5c42\u4e24\u5f20\u76f8\u90bb\u5207\u7247\u7684\u67d3\u8272\u7ec4\u7ec7\u5b66\uff08\u5de6\uff09\u3002(c) SpatialScope \u4f7f\u7528\u591a\u5207\u7247\u76f8\u90bb\u4fe1\u606f\uff08\u4e0a\uff09\u4e0e StarDist+RCTD \u4f7f\u7528\u591a\u5207\u7247\u76f8\u90bb\u4fe1\u606f\uff08\u4e0b\uff09\u7684\u7ec6\u80de\u7c7b\u578b\u9274\u5b9a\u7ed3\u679c\u6bd4\u8f83\uff08\u5de6\uff1a\u5c0f\u9f20\u5927\u8111\u76ae\u5c42\u5207\u7247 1\uff1b\u53f3\uff1a\u5c0f\u9f20\u5927\u8111\u76ae\u5c42\u5207\u7247 2\uff09\u3002(d) \u9876\u90e8\uff1aSpatialScope \u4f7f\u7528\u591a\u5207\u7247\u786e\u5b9a\u7684 L4\u3001L5 IT\u3001L6b\/L6 CT\/L6 IT\u3001Oligo \u548c VLMC \u7684\u7a7a\u95f4\u7ec6\u80de\u4f4d\u7f6e\u3002\u4e2d\u95f4\uff1a\u539f\u59cb Visium \u6570\u636e\u4e2d\u76f8\u5e94\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u6807\u8bb0\u57fa\u56e0\u7684\u70b9\u7ea7\u8868\u8fbe\u6c34\u5e73\u3002\u5e95\u90e8\uff1aSpatialScope \u7cbe\u70bc\u7684\u76f8\u5e94\u6807\u8bb0\u57fa\u56e0\u7684\u5355\u7ec6\u80de\u5206\u8fa8\u7387\u8868\u8fbe\u6c34\u5e73\u3002(e) SpatialScope \u751f\u6210\u7684\u4e09\u7ef4\u5bf9\u9f50\u5355\u7ec6\u80de\u5206\u8fa8\u7387\u7a7a\u95f4\u5206\u8fa8\u8f6c\u5f55\u7ec4\u6570\u636e\u4e2d\u68c0\u6d4b\u5230\u7684\u4e00\u4e9b\u4ee3\u8868\u6027\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u7684\u53ef\u89c6\u5316\u3002\u6563\u70b9\u56fe\u663e\u793a\u4e86\u914d\u4f53-\u53d7\u4f53\u5bf9\u5728\u76f8\u5e94\u7ec6\u80de\u7c7b\u578b\u5bf9\u4e2d\u7684\u8868\u8fbe\u6c34\u5e73\u3002\u914d\u4f53\u548c\u53d7\u4f53\u7684\u8868\u8fbe\u5206\u522b\u7528\u6a59\u8272\u548c\u7eff\u8272\u8868\u793a\u3002L \u7ec6\u80de\u7c7b\u578b\u8868\u8fbe\u914d\u4f53\u57fa\u56e0\uff0cR \u7ec6\u80de\u7c7b\u578b\u8868\u8fbe\u53d7\u4f53\u57fa\u56e0\u3002<\/span><\/p>\n


<\/span><\/p>\n

\n

<\/span><\/section>\n
\u7f16\u8bd1\uff5c\u90ed\u745e\u4e1c<\/span><\/section>\n

<\/section>\n
\n
\n
\n
\n

\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1a<\/strong><\/p>\n

AI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a\u542f\u52a8<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/section>\n

<\/span><\/a><\/p>\n


<\/p>\n

\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/span><\/p>\n

\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1aAI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a\u542f\u52a8<\/a><\/span>
<\/span><\/p>\n


<\/span><\/span><\/p>\n


<\/span><\/span><\/p>\n

\n

\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n<\/section>\n

\u200d<\/span>1. <\/strong>Nature\u901a\u8baf\uff1a\u901a\u8fc7\u6df1\u5ea6\u751f\u6210\u7f51\u7edc\u5bf9\u5355\u7ec6\u80de\u8f6c\u5f55\u6570\u636e\u8fdb\u884c\u53cc\u66f2\u5d4c\u5165<\/a><\/strong><\/span><\/strong><\/strong><\/section>\n
2.<\/strong> PNAS\u524d\u6cbf\uff1a\u6982\u7387\u5bc6\u5ea6\u4f30\u8ba1\u7684\u6df1\u5ea6\u751f\u6210\u795e\u7ecf\u7f51\u7edc\u65b9\u6cd5<\/a><\/strong><\/span><\/strong><\/section>\n
3.<\/strong><\/strong> \u6df1\u5ea6\u56fe\u751f\u6210\u6a21\u578b\u7efc\u8ff0\uff1a5\u7c7b\u6a21\u578b\u53ca\u524d\u666f\uff08\u9644PDF\u4e0b\u8f7d\uff09<\/a><\/strong><\/strong><\/span><\/section>\n
<\/strong><\/strong><\/strong><\/section>\n
4. <\/strong><\/strong><\/span>\u5f20\u6c5f\uff1a\u7b2c\u4e09\u4ee3\u4eba\u5de5\u667a\u80fd\u6280\u672f\u57fa\u7840\u2014\u2014\u4ece\u53ef\u5fae\u5206\u7f16\u7a0b\u5230\u56e0\u679c\u63a8\u7406 | \u96c6\u667a\u5b66\u56ed\u5168\u65b0\u8bfe\u7a0b<\/a><\/strong><\/strong><\/span><\/section>\n
5. <\/strong><\/strong>\u6210\u4e3a\u96c6\u667aVIP\uff0c\u89e3\u9501\u5168\u7ad9\u8bfe\u7a0b\uff0f\u8bfb\u4e66\u4f1a<\/a><\/span><\/strong><\/strong><\/strong><\/section>\n
6. <\/strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/span><\/a><\/section>\n

<\/section>\n

<\/section>\n
\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/strong><\/span><\/strong><\/section>\n

<\/mp-style-type><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5173\u952e\u8bcd\uff1a\u6df1\u5ea6\u751f\u6210\u6a21\u578b\uff0c\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\uff0c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\uff0c\u6570\u636e\u6574\u5408 \u8bba\u6587\u9898\u76ee\uff1a\uff1aIntegrating spatial and single-cell transcriptomics data using deep generative models with SpatialScope \u8bba\u6587\u671f\u520a\uff1aNature…<\/p>\n","protected":false},"author":0,"featured_media":47022,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/47029"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=47029"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/47029\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/47022"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=47029"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=47029"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=47029"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=47029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}