{"id":48938,"date":"2024-03-15T16:43:40","date_gmt":"2024-03-15T08:43:40","guid":{"rendered":"https:\/\/swarma.org\/?p=48938"},"modified":"2024-03-15T16:43:40","modified_gmt":"2024-03-15T08:43:40","slug":"%e5%a4%8d%e6%9d%82%e6%80%a7%e4%b8%ad%e4%bd%95%e4%bb%a5%e6%b6%8c%e7%8e%b0%e7%ae%80%e5%8d%95%e6%80%a7%ef%bc%9fsloppy%e6%a8%a1%e5%9e%8b%e6%8d%95%e6%8d%89%e5%a4%8d%e6%9d%82%e7%b3%bb%e7%bb%9f%e7%9a%84","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=48938","title":{"rendered":"\u590d\u6742\u6027\u4e2d\u4f55\u4ee5\u6d8c\u73b0\u7b80\u5355\u6027\uff1fSloppy\u6a21\u578b\u6355\u6349\u590d\u6742\u7cfb\u7edf\u7684\u5173\u952e\u81ea\u7531\u5ea6"},"content":{"rendered":"
\n
\n
\n
\n

<\/p>\n<\/section>\n

\n
\n
\n
\n
\n
\n

<\/section>\n<\/section>\n
\n
\n

\u5f15\u8a00<\/strong><\/p>\n<\/section>\n<\/section>\n

\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\u5728\u63a2\u7d22\u81ea\u7136\u754c\u7684\u5965\u79d8\u65f6\uff0c\u6211\u4eec\u5e38\u5e38\u88ab\u590d\u6742\u7cfb\u7edf\u7684\u7cbe\u5999\u6240\u5438\u5f15\u3002\u4ece\u661f\u7cfb\u7684\u65cb\u8f6c\u5230\u751f\u6001\u7cfb\u7edf\u7684\u5e73\u8861\uff0c\u518d\u5230\u4eba\u7c7b\u5927\u8111\u7684\u590d\u6742\u7f51\u7edc\uff0c\u8fd9\u4e9b\u7cfb\u7edf\u4ee5\u5176\u9519\u7efc\u590d\u6742\u7684\u7ed3\u6784\u548c\u52a8\u6001\u884c\u4e3a\u6311\u6218\u7740\u6211\u4eec\u7684\u7406\u89e3\u3002\u7136\u800c\uff0c\u5c3d\u7ba1\u8fd9\u4e9b\u7cfb\u7edf\u5728\u5fae\u89c2\u5c42\u9762\u4e0a\u62e5\u6709\u6781\u9ad8\u7684\u81ea\u7531\u5ea6\uff0c\u6211\u4eec\u5374\u80fd\u591f\u7528\u76f8\u5bf9\u7b80\u5355\u7684\u6a21\u578b\u6765\u63cf\u8ff0\u5b83\u4eec\u5728\u5b8f\u89c2\u5c42\u9762\u7684\u884c\u4e3a\u3002\u8fd9\u4e00\u73b0\u8c61\u5f15\u53d1\u4e86\u4e00\u4e2a\u6df1\u523b\u7684\u95ee\u9898\uff1a\u7531\u5927\u91cf\u53c2\u6570\u6240\u786e\u5b9a\u7684\u590d\u6742\u7cfb\u7edf\uff08\u5982\u5927\u8111\uff09\uff0c\u5176\u52a8\u529b\u5b66\u662f\u5426\u53ef\u4ee5\u7531\u8f83\u5c11\u7684\u81ea\u7531\u5ea6\u6240\u786e\u5b9a\u548c\u63a7\u5236\uff1f<\/span><\/strong><\/section>\n

<\/span><\/strong><\/section>\n
<\/span><\/strong>\u5728\u96c6\u667a\u4ff1\u4e50\u90e8\u300c\u8ba1\u7b97\u795e\u7ecf\u79d1\u5b66\u8bfb\u4e66\u4f1a<\/a>\u300d\uff0c\u9999\u6e2f\u6d78\u4f1a\u5927\u5b66\u7269\u7406\u7cfb\u5510\u4e7e\u5143\u8001\u5e08<\/span><\/strong>\u6df1\u5165\u63a2\u8ba8\u4e86\u590d\u6742\u7cfb\u7edf\u7684\u7a33\u5b9a\u6027\u4e0e\u654f\u611f\u6027\uff0c\u4ee5\u53caSloppy\u6a21\u578b\u5728\u795e\u7ecf\u79d1\u5b66\u4e2d\u7684\u5e94\u7528\u3002\u4eca\u5929\u7684\u6587\u7ae0\u662f\u6b64\u6b21\u8bfb\u4e66\u4f1a\u5206\u4eab\u6838\u5fc3\u5185\u5bb9\u7684\u6574\u7406\u3002<\/span><\/strong><\/span><\/strong><\/section>\n

<\/section>\n<\/section>\n
\n
\u7814\u7a76\u9886\u57df\uff1a\u590d\u6742\u7cfb\u7edf\uff0c\u8111<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong>\u79d1\u5b66\uff0cSloppy\u6a21\u578b\uff0c\u4f0a\u8f9b\u6a21\u578b\uff0c\u4fe1\u606f\u51e0\u4f55\uff0c\u6700\u5927\u71b5\u6a21\u578b\uff0c\u81ea\u7136\u6f14\u5316<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/section>\n<\/section>\n
\n
<\/span><\/strong><\/section>\n<\/section>\n
\n
<\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
\n
\u5085\u6e25\u6210<\/span><\/span><\/span> | \u8bb2\u8005<\/span><\/strong><\/section>\n
\u8c37\u6d77<\/span><\/span><\/span><\/span> <\/span>| \u6574\u7406<\/span><\/strong><\/span><\/strong><\/section>\n

<\/section>\n

<\/section>\n<\/section>\n
\n
\n
\n
\u590d\u6742\u7cfb\u7edf\u4e0d\u4ec5\u5728\u53d8\u91cf\u7a7a\u95f4\u6709\u7740\u6781\u9ad8\u7684\u81ea\u7531\u5ea6\uff0c\u5176\u5728\u53c2\u6570\u7a7a\u95f4\u540c\u6837\u4e5f\u6709\u975e\u5e38\u9ad8\u7684\u81ea\u7531\u5ea6\u3002\u5728\u5927\u91cf\u53c2\u6570\u4e0d\u786e\u5b9a\u7684\u60c5\u51b5\u4e0b\uff0c\u6211\u4eec\u662f\u5426\u4ecd\u7136\u53ef\u4ee5\u5bf9\u7cfb\u7edf\u7684\u52a8\u529b\u5b66\u60c5\u51b5\u8fdb\u884c\u9884\u6d4b\uff1f\u5982\u679c\u9519\u8bef\u5730\u4f30\u8ba1\u4e86\u67d0\u4e2a\u53c2\u6570\uff0c\u6211\u4eec\u6240\u9884\u6d4b\u7684\u52a8\u529b\u5b66\u4f1a\u8ddf\u539f\u6765\u7684\u52a8\u529b\u5b66\u4ea7\u751f\u600e\u6837\u7684\u5dee\u5f02\uff1f\u6709\u8da3\u7684\u662f\uff0c\u8bb8\u591a\u590d\u6742\u7cfb\u7edf\u7684\u5de5\u4f5c\u72b6\u6001\u4f3c\u4e4e\u4e0d\u4f1a\u7531\u4e8e\u90e8\u5206\u53c2\u6570\u7684\u6539\u53d8\u800c\u53d1\u751f\u5267\u70c8\u7684\u53d8\u5316<\/strong>\u3002\u4f8b\u5982\u4e00\u4e2a\u6df1\u5ea6\u5b66\u4e60\u7f51\u7edc\uff0c\u5176\u4e2d\u53ef\u80fd\u5305\u542b\u4e0a\u5343\u4e07\u4e2a\u53c2\u6570\uff0c\u4f46\u4e00\u4e2a\u80fd\u591f\u6709\u8f83\u597d\u6cdb\u5316\u80fd\u529b\u7684\u7f51\u7edc\uff0c\u5f80\u5f80\u4e0d\u4f1a\u56e0\u4e3a\u53c2\u6570\u7684\u6270\u52a8\u5f71\u54cd\u5176\u8868\u73b0\u3002Sloppy \u6a21\u578b<\/strong>\u6240\u63cf\u8ff0\u7684\u5c31\u662f\u8fd9\u6837\u4e00\u7c7b\u591a\u53c2\u6570\u6a21\u578b\uff0c\u8fd9\u7c7b\u6a21\u578b\u7684\u884c\u4e3a\u53ea\u53d6\u51b3\u4e8e\u51e0\u4e2a\u53c2\u6570\u7684\u4e25\u683c\u7ec4\u5408\uff0c\u800c\u53c2\u6570\u7684\u5176\u5b83\u7ec4\u5408\u65b9\u5f0f\u5bf9\u6a21\u578b\u9884\u6d4b\u6765\u8bf4\u5e76\u4e0d\u91cd\u8981\u3002\u8fd9\u6837\u7684\u6a21\u578b\u5728\u751f\u547d\u79d1\u5b66\u3001\u7269\u7406\u5b66\u548c\u4eba\u5de5\u667a\u80fd\u7b49\u9886\u57df\u4e2d\u65e0\u5904\u4e0d\u5728\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u6b64\u6b21\u8bfb\u4e66\u4f1a\u4ece\u7406\u8bba\u7269\u7406\u7684\u89d2\u5ea6\u51fa\u53d1\uff0c\u7ed3\u5408\u751f\u7269\u5b66\u548c\u4fe1\u606f\u8bba\u7684\u77e5\u8bc6\uff0c\u6765\u5206\u6790\u548c\u7406\u89e3\u590d\u6742\u7cfb\u7edf\u80cc\u540e\u7684\u6570\u5b66\u539f\u7406\u548c\u751f\u7269\u5b66\u89c4\u5f8b\uff0c\u76ee\u7684<\/span>\u4e0d\u4ec5\u662f\u63ed\u793a\u590d\u6742\u7cfb\u7edf\u5728\u5b8f\u89c2\u5c42\u9762\u4e0a\u7684\u7b80\u5316\u63cf\u8ff0\uff0c\u66f4\u662f\u63a2\u7d22\u8fd9\u79cd\u7b80\u5316\u80cc\u540e\u7684\u79d1\u5b66\u539f\u7406\u3002\u8bfb\u4e66\u4f1a<\/span>\u4e2d\u8ba8\u8bba\u4e86\u5982\u4f55\u901a\u8fc7Sloppy\u6a21\u578b\u8bc6\u522b\u7cfb\u7edf\u4e2d\u7684\u5173\u952e\u53c2\u6570\uff0c\u91cf\u5316\u52a8\u529b\u5b66\u4e0e\u7a33\u5b9a\u6027\u3002\u8fd9\u6837\u6211\u4eec\u53ef\u4ee5\u66f4\u597d\u5730\u7406\u89e3\u590d\u6742\u7cfb\u7edf\u7684\u5de5\u4f5c\u673a\u7406\uff0c\u4ee5\u53ca\u5982\u4f55\u5728\u4e0d\u540c\u73af\u5883\u548c\u6761\u4ef6\u4e0b\u7ef4\u6301\u5176\u529f\u80fd\u3002\u6b64\u5916\u8fd8\u8ba8\u8bba\u4e86\u5982\u4f55\u5229\u7528\u8fd9\u4e9b\u77e5\u8bc6\u8bbe\u8ba1\u66f4\u6709\u6548\u7684\u795e\u7ecf\u79d1\u5b66\u7814\u7a76\u65b9\u6cd5\uff0c\u5e76\u5c06\u8fd9\u4e9b\u539f\u7406\u5e94\u7528\u4e8e\u4eba\u5de5\u667a\u80fd\u548c\u5176\u4ed6\u6280\u672f\u9886\u57df\u3002<\/span><\/span><\/section>\n

<\/span><\/section>\n
\n

<\/section>\n<\/section>\n
\n
\n
\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

1. \u590d\u6742\u7cfb\u7edf\u7684Sloppiness<\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<\/section>\n<\/section>\n<\/section>\n

<\/span><\/section>\n
\u5728\u7269\u7406\u5b66\u4e2d\uff0c\u7406\u60f3\u6c14\u4f53\u7684\u5fae\u89c2\u7c92\u5b50\u867d\u7136\u81ea\u7531\u5ea6\u9ad8\uff0c\u4f46\u5b8f\u89c2\u4e0a\u6211\u4eec\u53ef\u4ee5\u7528\u6e29\u5ea6\u3001\u538b\u5f3a\u548c\u4f53\u79ef\u7b49\u7b80\u5355\u7684\u91cf\u6765\u63cf\u8ff0\u3002\u540c\u6837\uff0c\u5728\u751f\u7269\u5b66\u4e2d\uff0c\u7ec6\u83cc\u7fa4\u4f53\u7684\u751f\u957f\u548c\u8fdb\u5316\u867d\u7136\u590d\u6742\uff0c\u5374\u4e5f\u9075\u5faa\u4e00\u5b9a\u7684\u5b8f\u89c2\u89c4\u5f8b\u3002\u8fd9\u4e9b\u73b0\u8c61\u8ba9\u6211\u4eec\u601d\u8003\uff1a\u5bf9\u4e8e\u590d\u6742\u7cfb\u7edf\uff0c\u6211\u4eec\u80fd\u5426\u5728\u5b8f\u89c2\u5c42\u9762\u4e0a\u7528\u8f83\u5c11\u7684\u53c2\u6570\u6765\u6355\u6349\u5176\u4e3b\u8981\u7279\u5f81\u548c\u79e9\u5e8f\uff1f<\/span><\/section>\n

<\/span><\/section>\n
<\/section>\n

<\/section>\n
\u672c\u56fe\u7247\u6765\u81ea\u4e8e\u4e2d\u79d1\u9662\u7269\u7406\u6240\u738b\u78ca\u8001\u5e08\u7684PPT<\/span><\/section>\n

<\/section>\n
\u8fd9\u4e00\u95ee\u9898\u7684\u7b54\u6848\uff0c\u6216\u8bb8\u53ef\u4ee5\u4ece\u6211\u4eec\u5bf9\u73b0\u5b9e\u4e16\u754c\u7684\u89c2\u5bdf\u4e2d\u5f97\u5230\u542f\u793a\u3002\u4f8b\u5982\uff0c\u5f53\u6211\u4eec\u89c2\u5bdf\u4e00\u5e45\u7531\u968f\u673a\u50cf\u7d20\u7ec4\u6210\u7684\u56fe\u50cf\u65f6\uff0c\u5f88\u96be\u4ece\u5355\u4e2a\u50cf\u7d20\u63a8\u65ad\u51fa\u5468\u56f4\u50cf\u7d20\u7684\u4fe1\u606f\u3002\u7136\u800c\uff0c\u5f53\u6211\u4eec\u9762\u5bf9\u81ea\u7136\u754c\u4e2d\u7684\u56fe\u50cf\u65f6\uff0c\u5982\u624b\u5199\u6570\u5b57\u6216\u81ea\u7136\u98ce\u666f\uff0c\u5374\u80fd\u591f\u8f7b\u6613\u5730\u6839\u636e\u4e00\u90e8\u5206\u4fe1\u606f\u9884\u6d4b\u6574\u4f53\u7684\u6a21\u5f0f\u3002\u8fd9\u79cd\u80fd\u529b\u6e90\u81ea\u4e8e\u81ea\u7136\u754c\u4e2d\u7684\u7269\u4f53\u548c\u73b0\u8c61\u4e4b\u95f4\u5b58\u5728\u7740\u67d0\u79cd\u5185\u5728\u7684\u5173\u8054\u6027\u3002\u6b63\u662f\u8fd9\u79cd\u5173\u8054\u6027\uff0c\u4f7f\u5f97\u6211\u4eec\u7684\u4e16\u754c\u53d8\u5f97\u6709\u5e8f\uff0c\u4e5f\u4f7f\u5f97\u79d1\u5b66\u63a2\u7d22\u6210\u4e3a\u53ef\u80fd\u3002\u8fd9\u4e9b\u89c2\u5bdf\u7ed3\u679c\u5411\u6211\u4eec\u5c55\u793a\u4e86\u4e00\u4e2a\u5173\u952e\u7684\u4e8b\u5b9e\uff1a\u5c3d\u7ba1\u4e16\u754c\u590d\u6742\u591a\u53d8\uff0c\u4f46\u5b83\u5e76\u975e\u968f\u673a\u65e0\u5e8f\uff0c\u800c\u662f\u9075\u5faa\u7740\u67d0\u79cd\u53ef\u7406\u89e3\u7684\u89c4\u5f8b\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u80fd\u7528\u5b8f\u89c2\u4e0a\u7684\u4f4e\u81ea\u7531\u5ea6\u6765\u63cf\u8ff0\u9ad8\u81ea\u7531\u5ea6\u7684\u590d\u6742\u7cfb\u7edf\uff0c\u5373\u53ea\u6709\u5c11\u6570\u81ea\u7531\u5ea6\u662f\u5173\u952e\u7684\u3002\u8fd9\u6b63\u662fSloppy\u65b9\u6cd5\u7684\u7406\u8bba\u57fa\u7840<\/strong>\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u5177\u4f53\u6765\u8bf4\uff0c\u5bf9\u4e8e\u50cf\u7406\u60f3\u6c14\u4f53\u8fd9\u6837\u7684\u72ec\u7acb\u7c92\u5b50\u7cfb\u7edf\uff0c\u5176\u8054\u5408\u5206\u5e03\u53ef\u4ee5\u901a\u8fc7\u5404\u4e2a\u72ec\u7acb\u5206\u5e03\u7684\u4e58\u79ef\u6765\u8868\u793a\uff0c\u4f8b\u5982\uff0c\u63cf\u8ff0\u6c14\u4f53\u5206\u5b50\u8fd0\u52a8\u901f\u7387\u7684\u9ea6\u514b\u65af\u97e6-\u73bb\u5c14\u5179\u66fc\u5206\u5e03\u53ef\u4ee5\u88ab\u63cf\u8ff0\u4e3a\u5177\u67093\u4e2a\u81ea\u7531\u5ea6\u7684\u03c7\u5206\u5e03\u3002\u800c\u5bf9\u4e8e\u975e\u72ec\u7acb\u7c92\u5b50\u7cfb\u7edf\uff0c\u5b83\u4eec\u5728\u5b8f\u89c2\u5c42\u9762\u4e0a\u7684\u7b80\u5316\u4e3b\u8981\u5f52\u56e0\u4e8e\u4e09\u4e2a\u56e0\u7d20\u3002\u9996\u5148\uff0c\u7cfb\u7edf\u672c\u8eab\u53d7\u5230\u7269\u7406\u548c\u51e0\u4f55\u7ea6\u675f\u3002\u5176\u6b21\uff0c\u590d\u6742\u7cfb\u7edf\u5728\u5f62\u6210\u8fc7\u7a0b\u4e2d\u5fc5\u987b\u62b5\u6297\u566a\u58f0\uff0c\u5e76\u4e14\u4e3a\u4e86\u4fdd\u6301\u5176\u4efb\u52a1\u8868\u73b0\u7684\u6cdb\u5316\u80fd\u529b\uff0c\u4e0d\u80fd\u5bf9\u6bcf\u4e2a\u53c2\u6570\u90fd\u8fc7\u4e8e\u654f\u611f\u3002\u6700\u540e\uff0c\u590d\u6742\u7cfb\u7edf\u7684\u6f14\u5316\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u51fa\u73b0\u8def\u5f84\u4f9d\u8d56\uff0c\u4e00\u4e9b\u7b80\u5355\u7684\u7ed3\u6784\u4e00\u65e6\u51fa\u73b0\uff0c\u5c31\u66f4\u5bb9\u6613\u88ab\u9009\u62e9<\/span>\uff08\u4f8b\u5982\u667a\u80fd\u624b\u673a\u5f62\u6001\u7684\u201c\u8d8b\u540c\u8fdb\u5316\u201d\uff09<\/span>\u3002<\/span><\/section>\n

<\/section>\n

<\/section>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

2. \u5efa\u6a21\u590d\u6742\u7cfb\u7edf<\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u4e3a\u4e86\u6a21\u62df\u6211\u4eec\u4e4b\u524d\u8ba8\u8bba\u7684\u8fd9\u4e9b\u7279\u6027\uff0c\u4e00\u4e2a\u7ecf\u5178\u7684\u9009\u62e9\u662fIsing\u6a21\u578b\u3002\u8fd9\u4e2a\u6a21\u578b\u6700\u521d\u662f\u4e3a\u4e86\u63cf\u8ff0\u78c1\u6027\u6750\u6599\u7684\u7279\u6027\u800c\u63d0\u51fa\u7684\u3002\u5176\u6570\u5b66\u8868\u8fbe\u5f0f\u5982\u4e0b\uff1a<\/span><\/section>\n

<\/span><\/section>\n
<\/section>\n

<\/section>\n
\u5176\u4e2d\uff0c\u03c3j<\/span><\/sub><\/span>\u8868\u793a\u7b2cj\u4e2a\u4f4d\u7f6e\u5904\u7684\u81ea\u65cb\u65b9\u5411\uff0cJij<\/sub>\u4e0e\u03bc<\/span>\u5747\u4e3a\u53c2\u6570\u3002<\/span><\/section>\n

<\/span><\/section>\n
Ising\u6a21\u578b\u4e2d\uff0c<\/sub><\/span>\u8868\u793a\u76f8\u4e92\u4f5c\u7528\uff0c<\/sub><\/span>\u8868\u793a\u4e2a\u4f53\u7279\u5f81\u3002\u800c\u795e\u7ecf\u52a8\u529b\u5b66\u540c\u6837\u7531\u4e24\u4e2a\u65b9\u9762\u7684\u56e0\u7d20\u6240\u51b3\u5b9a\uff0c\u4e00\u65b9\u9762\u662f\u7531\u795e\u7ecf\u5143\u672c\u8eab\u7684\u67d0\u79cd\u6027\u8d28\uff0c\u53e6\u4e00\u65b9\u9762\u662f\u7531\u795e\u7ecf\u5143\u4e0e\u795e\u7ecf\u5143\u4e4b\u95f4\u7684\u67d0\u79cd\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u53ef\u4ee5\u4f7f\u7528\u7c7b\u4f3c\u7684Ising\u6a21\u578b\u6765\u6a21\u62df\u795e\u7ecf\u52a8\u529b\u5b66\u3002<\/span><\/section>\n

<\/span><\/section>\n

<\/p>\n

\u56fe\u7247\u6765\u6e90\uff1aSzekely, P., Sheftel, H., Mayo, A., & Alon, U. (2013). PLoS Comp Biol, 9(8), e1003163.<\/span><\/p>\n


<\/section>\n
\u901a\u5e38\u6211\u4eec\u8ba4\u4e3a\uff0c\u53c2\u6570\u51b3\u5b9a\u4e86\u6a21\u578b\u7684\u6f14\u5316\uff0c\u5373\u53c2\u6570\u51b3\u5b9a\u52a8\u529b\u5b66\u3002\u5728\u6587\u732e[1]\u4e2d\u63d0\u5230\u7684\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u4e2d\uff0c\u5c3d\u7ba1\u6709\u8bb8\u591a\u53c2\u6570\uff0c\u4f46\u5373\u4f7f\u4e0d\u5b8c\u5168\u4e86\u89e3\u8fd9\u4e9b\u53c2\u6570\uff0c\u6211\u4eec\u4e5f\u80fd\u628a\u63e1\u6574\u4e2a\u7cfb\u7edf\u7684\u52a8\u529b\u5b66\u3002\u6587\u4e2d\u5206\u6790\u4e86\u4e24\u4e2a\u53c2\u6570\u7684\u53d6\u503c\u5173\u7cfb\uff0c\u5982\u679c\u53c2\u6570\u53d6\u503c\u662f\u65e0\u5173\u7684\uff0c\u90a3\u5c31\u5e94\u8be5\u5982\u4e0a\u56fe\u4e2dd\u6240\u793a\uff0c\u4f46\u662f\u5b9e\u9645\u5f97\u5230\u7684\u5374\u662f\u56fee\uff0c\u8fd9\u610f\u5473\u7740\u53c2\u6570\u4e4b\u95f4\u6709\u7740\u67d0\u79cd\u7ea6\u675f\u3002\u90a3\u4e48\u4e3a\u4ec0\u4e48\u4f1a\u6709\u8fd9\u79cd\u7ea6\u675f\u5462\uff1f\u56e0\u4e3a\u751f\u7269\u4f53\u8868\u73b0\u51fa\u7684\u52a8\u529b\u5b66\u5e76\u975e\u968f\u673a\uff0c\u56e0\u6b64\u5bf9\u52a8\u529b\u5b66\u6709\u7279\u5b9a\u8981\u6c42\u7684\u53c2\u6570\u4e5f\u4f1a\u53d7\u5230\u9650\u5236\uff0c\u4f7f\u5f97\u53c2\u6570\u7684\u9009\u62e9\u6700\u7ec8\u843d\u5728\u4e00\u4e2a\u66f4\u4f4e\u7ef4\u7684\u5b50\u7a7a\u95f4\u5185\u3002<\/span><\/section>\n

<\/span><\/section>\n


<\/h3>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

3. \u7ed3\u6784\u3001\u53c2\u6570\u4e0e\u52a8\u529b\u5b66<\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u4e0a\u9762\u7684\u73b0\u8c61\u4f7f\u5f97\u6211\u4eec\u60f3\u8fdb\u4e00\u6b65\u63a2\u8ba8\u53c2\u6570\u4e0e\u52a8\u529b\u5b66\u7684\u5173\u7cfb\u3002\u5728\u7269\u7406\u5b66\u4e2d\uff0c\u53c2\u6570\u7684\u4e0d\u540c\u53d6\u503c\u4f1a\u5bfc\u81f4\u7cfb\u7edf\u968f\u65f6\u95f4\u6f14\u5316\u7684\u5dee\u5f02\uff0c\u8fdb\u800c\u5f71\u54cd\u6211\u4eec\u89c2\u6d4b\u5230\u7684\u73b0\u8c61\u3002\u4ee5\u5927\u8111\u4e3a\u4f8b\uff0c\u91c7\u7528Ising\u6a21\u578b\u5efa\u6a21\uff0c\u5b83\u7684\u53c2\u6570\u4e3b\u8981\u63cf\u8ff0\u4e86\u5927\u8111\u4e0d\u540c\u533a\u57df\u7684\u6d3b\u8dc3\u6027\u4ee5\u53ca\u5b83\u4eec\u4e4b\u95f4\u7684\u8fde\u63a5\u60c5\u51b5\u3002\u800c\u8fd9\u4e9b\u53c2\u6570\u53d1\u751f\u6539\u53d8\uff0c\u5927\u8111\u52a8\u529b\u5b66\u4e5f\u5c06\u5bf9\u5e94\u53d1\u751f\u6539\u53d8\u3002\u5728\u7edf\u8ba1\u5b66\u7684\u89c6\u89d2\u4e0b\uff0c\u4e00\u65e6\u53c2\u6570\u786e\u5b9a\u4e86\uff0c\u968f\u673a\u53d8\u91cf\u7684\u5206\u5e03\u4e5f\u5c31\u968f\u4e4b\u786e\u5b9a\u3002\u4f8b\u5982\uff0c\u53ea\u8981\u6211\u4eec\u77e5\u9053\u5747\u503c\u548c\u65b9\u5dee\uff0c\u5c31\u80fd\u5b9a\u4e49\u4e00\u4e2a\u9ad8\u65af\u5206\u5e03\u3002\u8fd9\u79cd\u5173\u7cfb\u4f7f\u6211\u4eec\u80fd\u591f\u901a\u8fc7\u89c2\u6d4b\u6570\u636e\u6765\u63a8\u65ad\u53c2\u6570\uff0c\u8fd9\u5c31\u662f\u53c2\u6570\u4f30\u8ba1\u65b9\u6cd5\u7684\u57fa\u7840\u3002<\/span><\/section>\n

<\/span><\/section>\n

<\/section>\n
<\/section>\n

<\/section>\n
\u66f4\u4e00\u822c\u5730\uff0c\u6211\u4eec\u8003\u8651\u53c2\u6570\u7a7a\u95f4<\/strong><\/span>\uff08\u53c2\u6570\u6240\u6784\u6210\u7684\u7a7a\u95f4\uff09<\/span>\u4e0e\u884c\u4e3a\u7a7a\u95f4<\/strong><\/span>\uff08\u53d8\u91cf\u6240\u6784\u6210\u7684\u7a7a\u95f4\uff09<\/span>\u7684\u5173\u7cfb\uff0c\u5982\u4e0b\u8868\u3002\u5728\u8bf8\u591a\u9886\u57df\u6211\u4eec\u90fd\u53ef\u4ee5\u53d1\u73b0\u53c2\u6570\u51b3\u5b9a\u4e86\u884c\u4e3a\uff0c\u4f46\u540c\u65f6\u8fdb\u5316\u53c8\u53cd\u8fc7\u6765\u901a\u8fc7\u9009\u62e9\u884c\u4e3a\u786e\u5b9a\u4e86\u4e00\u4e9b\u53c2\u6570\u4e4b\u95f4\u7684\u7ea6\u675f\u3002<\/span><\/section>\n

<\/section>\n
<\/section>\n

<\/section>\n
\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528\u4fc3\u4f7f\u6211\u4eec\u8fdb\u4e00\u6b65\u7814\u7a76\u53c2\u6570\u53d8\u5316\u4e0e\u884c\u4e3a\u53d8\u5316\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u6211\u4eec\u53d1\u73b0\u4e00\u4e9b\u53c2\u6570\u7684\u6539\u53d8\u51e0\u4e4e\u4e0d\u4f1a\u5f71\u54cd\u52a8\u529b\u5b66\uff0c\u800c\u53e6\u5916\u4e00\u4e9b\u53c2\u6570\u4e00\u65e6\u6270\u52a8\uff0c\u52a8\u529b\u5b66\u5c06\u53d1\u751f\u5de8\u5927\u6539\u53d8\u3002\u4e8e\u662f\u6211\u4eec\u5c06\u524d\u8005\u79f0\u4e3aSloppy\u7684\u53c2\u6570\uff0c\u800c\u540e\u8005\u654f\u611f\u6027\u7684\u53c2\u6570\u88ab\u79f0\u4e3aStiff\u7684<\/strong>\u3002<\/span><\/section>\n

<\/span><\/section>\n
<\/section>\n

<\/section>\n
\u4e3a\u4e86\u66f4\u4e25\u683c\u5730\u8861\u91cf\u8fd9\u79cd\u52a8\u529b\u5b66\u7684\u53d8\u5316\uff0cSethna\u63d0\u51fa\u4e86\u4e00\u79cd\u5ea6\u91cf\u65b9\u5f0f[2]\uff0c\u516c\u5f0f\u5982\u4e0b\uff1a<\/span><\/section>\n

<\/span><\/section>\n
<\/section>\n

<\/section>\n
\u8be5\u516c\u5f0f\u8ba1\u7b97\u4e86\u5728\u65f6\u95f4t\u5185\uff0c\u7cfb\u7edf\u7531\u03b8*<\/sup><\/span>\u53d8\u4e3a\u03b8<\/span>\uff0c\u52a8\u529b\u5b66\u53d1\u751f\u7684\u6539\u53d8<\/sub><\/span>\uff0c\u5e76\u8fdb\u884c\u5f52\u4e00\u5316\u5904\u7406\u3002<\/span><\/section>\n

<\/section>\n

<\/section>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

4. Sloppy\u6a21\u578b<\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u57fa\u4e8e\u8fd9\u4e9b\u60f3\u6cd5\uff0cSethna\u5bf9\u591a\u79cd\u7cfb\u7edf\u8fdb\u884c\u4e86\u6df1\u5165\u7814\u7a76\uff0c\u63d0\u51fa\u4e86Sloppy\u6a21\u578b\u7684\u6982\u5ff5<\/span>\uff08\u5982\u4e0b\u56fe\u6240\u793a\uff09<\/span>\u3002\u5927\u91cf\u7814\u7a76\u8868\u660e\uff0c\u5728\u7edd\u5927\u591a\u6570\u751f\u7269\u7cfb\u7edf\u4e2d\uff0c\u5927\u90e8\u5206\u53c2\u6570\u90fd\u5177\u6709Sloppy\u7279\u6027\uff0c\u800c\u53ea\u6709\u5c11\u6570\u53c2\u6570\u626e\u6f14\u7740\u5173\u952e\u89d2\u8272\u3002<\/span><\/section>\n

<\/section>\n
<\/section>\n

<\/section>\n
\u4e3a\u4e86\u5b9a\u91cf\u63cf\u8ff0\u53c2\u6570\u7684\u7a33\u5b9a\u6027\uff0c\u6211\u4eec\u5f15\u5165\u4e86Fisher\u4fe1\u606f\u77e9\u9635\uff0c\u5b83\u7531\u53c2\u6570\u7684\u4e8c\u9636\u5bfc\u6570\u6784\u6210\uff0c\u53cd\u6620\u4e86\u6982\u7387\u5206\u5e03\u7684\u51f9\u51f8\u6027<\/span>\uff08\u6ce8\uff1a\u8fd9\u91cc\u7684\u8ba8\u8bba\u7b80\u5316\u4e86\u95ee\u9898\uff0c\u4e25\u683c\u6765\u8bf4\uff0c\u8fd9\u79cd\u7531\u4e8c\u9636\u5bfc\u6570\u6240\u5b9a\u4e49\u7684Fisher\u4fe1\u606f\u77e9\u9635\u4e3a\u201c\u89c2\u6d4bFisher\u4fe1\u606f\u201d\uff0c\u5373 Observed fisher information\uff09<\/span>\u3002\u4e00\u4e2a\u5206\u5e03\u7684\u51f9\u51f8\u6027\u8d8a\u5927\uff0c\u8868\u660e\u5176\u8d8a\u4e0d\u7a33\u5b9a\uff0c\u8574\u542b\u7684\u4fe1\u606f\u91cf\u8d8a\u5927\uff0c\u800c\u8fd9\u4e2a\u5206\u5e03\u7684\u5f62\u72b6\u6b63\u662f\u7531\u53c2\u6570\u51b3\u5b9a\u7684\u3002\u6545\u53ef\u4ee5\u7528Fisher\u4fe1\u606f\u77e9\u9635\u63cf\u8ff0\u6a21\u578b\u5bf9\u53c2\u6570\u7684\u7a33\u5b9a\u6027\u3002<\/span><\/section>\n

<\/span><\/section>\n

<\/p>\n


<\/section>\n

<\/section>\n
\u4e0b\u9762\u6211\u4eec\u66f4\u76f4\u89c2\u5730\u6765\u7406\u89e3Sloppy\u548cStiff\u3002\u6211\u4eec\u8bf4Sloppy\u6216Stiff\u7684\u7ef4\u5ea6\u6216\u65b9\u5411\uff0c\u53ef\u4ee5\u4e0d\u4ec5\u4ec5\u662f\u67d0\u4e2a\u5177\u4f53\u7684\u53c2\u6570\uff0c\u4e5f\u53ef\u4ee5\u662f\u53c2\u6570\u7684\u7ec4\u5408\u3002\u6570\u5b66\u4e0a\u7684\u7406\u89e3\u5c31\u662f\uff0c\u5bf9Fisher\u4fe1\u606f\u77e9\u9635\u6c42\u7279\u5f81\u503c\u548c\u7279\u5f81\u5411\u91cf\uff0c\u5176\u4e2d\u5bf9\u5e94\u6700\u5927\u7279\u5f81\u503c\u7684\u7279\u5f81\u5411\u91cf\u5c31\u662fFisher\u4fe1\u606f\u4e0b\u964d\u6700\u5feb\u7684\u65b9\u5411\uff0c\u76f8\u5e94\u7684\u53c2\u6570\u7ec4\u5408\u56e0\u6b64\u5bf9\u5e94\u4e8e\u80fd\u6700\u5927\u7a0b\u5ea6\u6539\u53d8\u7cfb\u7edf\u52a8\u529b\u5b66\u7684Stiff\u65b9\u5411\u3002\u5728\u5927\u91cf\u771f\u5b9e\u7684\u590d\u6742\u7cfb\u7edf\u4e2d\uff0cStiff\u7684\u7ef4\u5ea6\u5f80\u5f80\u8fdc\u8fdc\u5c0f\u4e8e\u7cfb\u7edf\u7684\u81ea\u7531\u5ea6\u6570\uff0c\u8fd9\u4e9b\u65b9\u5411\u4e0a\u7684\u6270\u52a8\u5c06\u4e25\u91cd\u5f71\u54cd\u7cfb\u7edf\u7684\u52a8\u529b\u5b66\u884c\u4e3a\uff0c\u5728\u76f8\u5e94\u65b9\u5411\u4e0a\u6982\u7387\u5206\u5e03\u51fd\u6570\u7684\u6295\u5f71\u5f62\u72b6\u66f4\u5c16\u9510\uff0c\u6709\u66f4\u5c0f\u7684\u65b9\u5dee\u3002\u5bf9\u4e8e\u5927\u591a\u6570\u7684Sloppy\u7684\u7ef4\u5ea6\uff0c\u8fd9\u4e9b\u7ef4\u5ea6\u4e0a\u53c2\u6570\u7684\u6270\u52a8\u5bf9\u7cfb\u7edf\u7684\u52a8\u529b\u5b66\u5f71\u54cd\u8f83\u5c0f\uff0c\u76f8\u5e94\u65b9\u5411\u4e0a\u6982\u7387\u5206\u5e03\u51fd\u6570\u7684\u6295\u5f71\u66f4\u5bbd\u6241\u3001\u66f4\u5927\u65b9\u5dee\u3002<\/span><\/section>\n

<\/section>\n
<\/section>\n

<\/section>\n
\u8fd9\u4e00\u5957\u57fa\u4e8eFisher\u4fe1\u606f\u7684\u8bed\u8a00\u6784\u6210\u4e86\u4e00\u4e2a\u65b0\u7684\u5b66\u79d1\u2014\u2014\u4fe1\u606f\u51e0\u4f55<\/strong>\u3002\u4fe1\u606f\u51e0\u4f55\u80cc\u540e\u7684\u7406\u8bba\u57fa\u7840\u5c06\u6709\u52a9\u4e8e\u6211\u4eec\u5bf9\u7a33\u5b9a\u6027\u8fdb\u884c\u66f4\u6df1\u5165\u7684\u6570\u5b66\u5206\u6790\uff0c\u5982\u6211\u4eec\u53d1\u73b0Fisher\u4fe1\u606f\u5ea6\u91cf\u53ef\u4ee5\u7531KL\u6563\u5ea6\u7684\u4e8c\u9636\u5bfc\u5bfc\u51fa\uff0c\u8fd9\u5c31\u5efa\u7acb\u4e86\u53c2\u6570\u7a33\u5b9a\u6027\u4e0eKL\u6563\u5ea6\u4e4b\u95f4\u7684\u8054\u7cfb\u3002<\/span><\/section>\n

<\/span><\/section>\n
Sethna\u5728\u7814\u7a76Sloppy\u6a21\u578b\u7684\u65f6\u5019\u4e5f\u63d0\u51fa\u4e86\u7c7b\u4f3c\u7684\u60f3\u6cd5\u3002\u4ed6\u91c7\u7528\u52a8\u529b\u5b66\u7684\u53d8\u5316\u5173\u4e8e\u53c2\u6570\u5bf9\u6570\u7684\u4e8c\u9636\u5bfc\uff0c\u6765\u63cf\u8ff0\u53c2\u6570\u7684\u7a33\u5b9a\u6027[2]\uff0c\u8ba1\u7b97\u5982\u4e0b\uff1a<\/span><\/section>\n

<\/section>\n
<\/section>\n

<\/section>\n
\u4ee5\u4e0a\u5c31\u662fSloppy\u6a21\u578b\u57fa\u672c\u601d\u60f3\u7684\u6570\u5b66\u63cf\u8ff0\uff0c\u5510\u4e7e\u5143\u8001\u5e08\u8bfe\u9898\u7ec4\u5c06\u8fd9\u5957\u601d\u60f3\u7528\u5230\u86cb\u767d\u8d28\u7684\u8fdb\u5316\u95ee\u9898\u7684\u7814\u7a76\u4e0a[3]\uff0c\u4ee5\u86cb\u767d\u8d28\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u7684\u7a81\u53d8\u4f5c\u4e3a\u53c2\u6570\uff0c\u86cb\u767d\u8d28\u7684\u52a8\u529b\u5b66\u4f5c\u4e3a\u53d8\u91cf\uff0c\u53d1\u73b0\u4e86\u86cb\u767d\u8d28\u52a8\u529b\u5b66\u4e0e\u8fdb\u5316\u4e4b\u95f4\u5b58\u5728\u4e00\u79cd\u5bf9\u5e94\u5173\u7cfb\u3002\u60f3\u8981\u66f4\u5177\u4f53\u5730\u4e86\u89e3\u8bba\u6587\u7684\u8be6\u7ec6\u5185\u5bb9\uff0c\u8bf7\u9605\u8bfb\u6587\u732e[3]\u3002<\/span><\/section>\n

<\/section>\n

<\/section>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

5. \u5927\u8111\u7684\u6700\u5927\u71b5\u6a21\u578b<\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u6211\u4eec\u5e38\u5e38\u4f9d\u8d56\u4e8e\u6a21\u578b\u6765\u89e3\u91ca\u89c2\u5bdf\u5230\u7684\u73b0\u8c61\u3002\u7136\u800c\uff0c\u5728\u5b9e\u9645\u7684\u5efa\u6a21\u8fc7\u7a0b\u4e2d\uff0c\u5f80\u5f80\u9700\u8981\u4ece\u73b0\u8c61\u51fa\u53d1\uff0c\u53cd\u5411\u63a8\u5bfc\u51fa\u6a21\u578b\u53c2\u6570\u3002\u4f8b\u5982\uff0cAlphaFold\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u5b83\u901a\u8fc7\u5206\u6790\u540c\u5bb6\u65cf\u86cb\u767d\u8d28\u5e8f\u5217\u4e0d\u540c\u4f4d\u70b9\u95f4\u7a81\u53d8\u7684\u5173\u8054\u6027\u6765\u63a8\u65ad\u6c28\u57fa\u9178\u7684\u76f8\u5bf9\u4f4d\u7f6e\u3002\u540c\u6837\uff0c\u5728\u6784\u5efa\u8111\u7f51\u7edc\u65f6\uff0c\u6211\u4eec\u4e5f\u9700\u8981\u901a\u8fc7\u5206\u6790\u4e0d\u540c\u8111\u533a\u4fe1\u53f7\u7684\u5173\u8054\u6027\u6765\u63a8\u65ad\u7f51\u7edc\u7684\u7ed3\u6784\u3002<\/span><\/section>\n


<\/p>\n

\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\uff0c\u6c42\u89e3\u9006\u95ee\u9898\u2014\u2014\u5373\u4ece\u73b0\u8c61\u5012\u63a8\u53c2\u6570\u2014\u2014\u662f\u81f3\u5173\u91cd\u8981\u7684\u4e00\u6b65\u3002\u4e3a\u4e86\u5b9e\u73b0\u8fd9\u4e00\u76ee\u6807\uff0c\u4e00\u79cd\u5e38\u7528\u7684\u65b9\u6cd5\u662f\u6700\u5927\u71b5\u6a21\u578b\u3002<\/span>\u6700\u5927\u71b5\u6a21\u578b\u7684\u6838\u5fc3\u601d\u60f3\u662f\u5728\u6700\u5927\u4e0d\u786e\u5b9a\u6027<\/span>\uff08\u4ea6\u5373\u6700\u5c11\u5047\u8bbe\uff09<\/span>\u7684\u524d\u63d0\u4e0b\u4f30\u8ba1\u53c2\u6570\uff0c\u540c\u65f6\uff0c\u5982\u679c\u7cfb\u7edf\u672c\u8eab\u5e26\u6709\u7ea6\u675f\uff0c\u6211\u4eec\u53ef\u4ee5\u901a\u8fc7\u62c9\u683c\u6717\u65e5\u4e58\u5b50\u5728\u6570\u5b66\u4e0a\u5f15\u5165\u8fd9\u4e9b\u7ea6\u675f<\/span><\/strong>\u3002\u4f8b\u5982\uff0c\u5982\u679c\u6211\u4eec\u5df2\u77e5\u4e00\u4e2a\u7cfb\u7edf\u7684\u5747\u503c\u548c\u65b9\u5dee\uff0c\u90a3\u4e48\u5229\u7528\u6700\u5927\u71b5\u539f\u7406\uff0c\u6211\u4eec\u53ef\u4ee5\u5f97\u51fa\u8be5\u7cfb\u7edf\u9075\u5faa\u9ad8\u65af\u5206\u5e03\u3002\u5bf9\u4e8e\u5176\u4ed6\u5e38\u89c1\u7684\u6982\u7387\u5206\u5e03\u53ca\u5176\u5bf9\u5e94\u7684\u6700\u5927\u71b5\u7ea6\u675f\uff0c\u53ef\u4ee5\u53c2\u8003\u7ef4\u57fa\u767e\u79d1\u7684\u76f8\u5173\u6761\u76ee <\/span>(Maximum entropy probability distribution) <\/span>[7]\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u5728\u5177\u4f53\u7684\u5b9e\u9a8c\u4e2d\uff0c\u7814\u7a76\u8005\u4eec\u4f7f\u7528\u4e86\u57fa\u4e8e\u5927\u8111\u7684BOLD\u4fe1\u53f7[4]\u548c\u795e\u7ecf\u4fe1\u53f7\u53d1\u653e[5]\u7684\u6570\u636e\u3002\u901a\u8fc7\u6700\u5927\u71b5\u6a21\u578b\uff0c\u80fd\u591f\u8ba1\u7b97\u51fa\u6a21\u578b\u9884\u6d4b\u7684\u5747\u503c\u548c\u65b9\u5dee\uff0c\u5e76\u4e0e\u5b9e\u9645\u6570\u636e\u7684\u5747\u503c\u548c\u65b9\u5dee\u8fdb\u884c\u6bd4\u8f83\u3002\u5e76\u901a\u8fc7\u4e0b\u9762\u7684\u89c4\u5219\u8fdb\u884c\u8fed\u4ee3\uff0c\u6700\u7ec8\u5b66\u4e60\u5230\u76f8\u5e94\u7684\u53c2\u6570\uff1a<\/span><\/section>\n

<\/span><\/section>\n
<\/section>\n

<\/section>\n
\u5728\u8fd9\u4e2a\u5b66\u4e60\u8fc7\u7a0b\u4e2d\uff0c\u6a21\u578b\u5b66\u4e60\u4e86\u4e24\u4e2a\u5173\u952e\u7684\u5143\u7d20\uff1a\u4e0e\u8282\u70b9\u6d3b\u8dc3\u5ea6\u76f8\u5173\u7684hi<\/sub>\u548c\u4e0e\u8fde\u8fb9\u5f3a\u5ea6\u76f8\u5173\u7684Jij<\/sub>\u3002\u6b64\u5916\uff0c\u6587\u732e\u8fd8\u53d1\u73b0\uff1a\u5982\u679c\u6a21\u578b\u5ffd\u7565\u4e86\u8fde\u8fb9J<\/span>ij<\/sub>\uff0c\u5176\u6548\u679c\u4f1a\u6709\u6240\u4e0b\u964d\uff1b\u800c\u5f53\u540c\u65f6\u8003\u8651h<\/span>i<\/sub>\u548cJ<\/span>ij<\/sub>\u65f6\uff0c\u5373\u5f97\u5230\u4e86\u6240\u8c13\u7684pairwise\u6700\u5927\u71b5\u6a21\u578b<\/strong><\/span>\uff08MEM\uff09<\/span>\uff0c\u6a21\u578b\u7684\u8868\u73b0\u5f97\u5230\u4e86\u663e\u8457\u63d0\u5347\u3002pairwise\u6700\u5927\u71b5\u6a21\u578b\u7684\u6570\u5b66\u8868\u793a\u5982\u4e0b\uff1a<\/span><\/section>\n

<\/section>\n
<\/section>\n

<\/section>\n
\u5bf9\u8be5\u6a21\u578b\u8fdb\u4e00\u6b65\u8fdb\u884c\u7b80\u5316\u7684\u5047\u8bbe\uff0c\u5c31\u53ef\u4ee5\u5f97\u5230Ising\u6a21\u578b\u3002\u6b64\u5916\uff0c\u5f97\u5230\u53c2\u6570\u4e4b\u540e\u53ef\u4ee5\u4f7f\u7528\u8499\u7279\u5361\u6d1b\u65b9\u6cd5\u6765\u6a21\u62dfIsing\u6a21\u578b\uff0c\u4ee5\u9a8c\u8bc1\u6a21\u578b\u7684\u6709\u6548\u6027\u3002<\/span><\/section>\n

<\/section>\n
\u5728\u300aeLife\u300b\u53d1\u8868\u7684\u4e00\u7bc7\u6587\u7ae0\u4e2d[6]\uff0c\u7814\u7a76\u8005\u4f7f\u7528\u8001\u9f20\u542c\u89c9\u76ae\u5c42A1\u533a\u57df\u7684\u4fe1\u53f7\u53d1\u653e\u6570\u636e\uff0c\u4e5f\u5bf9\u6bd4\u4e86pairwise MEM\u4e0e\u72ec\u7acb\u6a21\u578b<\/span>\uff08independent model\uff09<\/span>\u3002\u800c\u5728\u300aNature Communications\u300b\u7684\u53e6\u4e00\u7bc7\u6587\u7ae0\u4e2d[4]\uff0c\u7814\u7a76\u8005\u8fd8\u5bf9\u6bd4\u4e86\u53e6\u5916\u4e24\u79cd\u65b9\u6cd5\uff1a\u76f4\u63a5\u6c42\u9006\u7684\u9ad8\u65af\u6a21\u578b<\/span>\uff08inverse Gaussian model\uff09<\/span>\u548c\u6c42\u9006\u540e\u8fdb\u884c\u5f52\u4e00\u5316\u7684\u504f\u76f8\u5173\u65b9\u6cd5<\/span>\uff08Partial correlation method\uff09<\/span>\u3002\u4ed6\u4eec\u5728\u9ed8\u8ba4\u6a21\u5f0f\u7f51\u7edc<\/span>\uff08DMN\uff09<\/span>\u548c\u989d\u9876\u7f51\u7edc<\/span>\uff08FPN\uff09<\/span>\u4e0a\uff0c\u91c7\u7528\u4e86pairwise MEM\u3001inverse Gaussian model\u3001Partial correlation method\u4ee5\u53ca\u4e92\u4fe1\u606f\u65b9\u6cd5\uff0c\u901a\u8fc7\u4e0e\u89e3\u5256\u8fde\u63a5\u3001\u529f\u80fd\u8fde\u63a5\u7684\u6bd4\u8f83\uff0c\u8fdb\u884c\u4e86\u76f8\u5173\u7684\u5206\u6790\uff0c\u9a8c\u8bc1\u4e86pairwise MEM\u5728\u6784\u5efa\u8111\u7f51\u7edc\u6a21\u578b\u4e2d\u7684\u4f18\u8d8a\u6027\u3002<\/span><\/section>\n

<\/span><\/section>\n

<\/section>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

6. \u5728\u795e\u7ecf\u79d1\u5b66\u4e2d\u7684\u5e94\u7528<\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u5728\u300aJournal of Neuroscience\u300b\u53d1\u8868\u7684\u4e00\u7bc7\u6587\u7ae0\u4e2d[5]\uff0c\u7814\u7a76\u8005\u4eec\u5bf9\u79bb\u4f53\u57f9\u517b\u7684\u795e\u7ecf\u7ec4\u7ec7\u8fdb\u884c\u4e86\u6df1\u5165\u7814\u7a76\u3002\u4ed6\u4eec\u7684\u5de5\u4f5c\u96c6\u4e2d\u5728\u4e24\u4e2a\u4e3b\u8981\u65b9\u9762\uff1a\u9996\u5148\uff0c\u4ed6\u4eec\u68c0\u9a8c\u4e86\u6a21\u578b\u62df\u5408\u53c2\u6570\u7684\u51c6\u786e\u6027\uff1b\u5176\u6b21\uff0c\u4ed6\u4eec\u5229\u7528Fisher\u4fe1\u606f\u6765\u8bc4\u4f30\u53c2\u6570\u7684\u7a33\u5b9a\u6027\uff0c\u5373\u5224\u65ad\u53c2\u6570\u662fSloppy\u8fd8\u662fStiff\u3002<\/span><\/section>\n

<\/span><\/section>\n
Fisher\u4fe1\u606f\u7684\u9ad8\u4f4e\u76f4\u63a5\u5173\u8054\u5230\u53c2\u6570\u7684\u7a33\u5b9a\u6027\uff0c\u4fe1\u606f\u8d8a\u9ad8\uff0c\u53c2\u6570\u8d8aStiff\uff0c\u7cfb\u7edf\u8d8a\u4e0d\u7a33\u5b9a\u3002\u7814\u7a76\u8005\u4eec\u7279\u522b\u5173\u6ce8\u4e86\u4e0e\u6b64\u76f8\u5173\u7684\u7279\u5f81\u5411\u91cf\uff0c\u56e0\u4e3a\u5b83\u4eec\u5728\u7406\u89e3\u7cfb\u7edf\u884c\u4e3a\u4e2d\u626e\u6f14\u7740\u91cd\u8981\u89d2\u8272\u3002\u901a\u8fc7\u9009\u62e9\u5177\u6709\u6700\u5927Fisher\u4fe1\u606f\u7684\u51e0\u4e2a\u7279\u5f81\u5411\u91cf\uff0c\u4ed6\u4eec\u80fd\u591f\u8bc6\u522b\u51fa\u5bf9\u7cfb\u7edf\u5f71\u54cd\u6700\u5927\u7684\u53c2\u6570\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u4e3a\u4e86\u8fdb\u4e00\u6b65\u5206\u6790\u53c2\u6570\u7684\u5206\u5e03\u7279\u6027\uff0c\u7814\u7a76\u8005\u4eec\u5f15\u5165\u4e86Gini\u7cfb\u6570\uff0c\u8fd9\u662f\u4e00\u4e2a\u8861\u91cf\u516c\u5e73\u6027\u7684\u6307\u6807\uff0c\u4e5f\u53ef\u4ee5\u7528\u6765\u523b\u753bFisher\u4fe1\u606f\u77e9\u9635\u7684\u7a00\u758f\u7a0b\u5ea6\u3002Gini\u7cfb\u6570\u8d8a\u5927\uff0c\u610f\u5473\u7740Stiff\u53c2\u6570\u8d8a\u5c11\uff0cSloppy\u53c2\u6570\u8d8a\u591a\uff0c\u8fd9\u4e3a\u7406\u89e3\u7cfb\u7edf\u7684\u7a33\u5b9a\u6027\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2<\/strong>\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u7814\u7a76\u7f51\u7edc\u53c2\u6570\u5728Fisher\u4fe1\u606f\u77e9\u9635\u7279\u5f81\u5411\u91cf\u4e0a\u7684\u6295\u5f71\uff0c\u4ed6\u4eec\u9a8c\u8bc1\u4e86\u6a21\u578b\u53c2\u6570\u5728\u7279\u5b9a\u65b9\u5411\u7684Sloppy\u548cStiff\u7279\u6027\uff0c\u5e76\u57fa\u4e8eLIF\u795e\u7ecf\u5143\u6a21\u578b\u4ece\u7406\u8bba\u7684\u89d2\u5ea6\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u5176\u7406\u8bba\u3002<\/span><\/section>\n

<\/section>\n
\u5728\u53e6\u4e00\u7bc7\u6587\u7ae0\u4e2d[6]\uff0c\u7814\u7a76\u8005\u4eec\u53d1\u73b0\uff0c\u5c3d\u7ba1\u53c2\u6570\u548c\u53c2\u6570\u7684\u53d8\u5316\u91cf\u53ef\u80fd\u4e0d\u7a33\u5b9a\uff0c\u4f46Fisher\u4fe1\u606f\u77e9\u9635\u7684\u7279\u5f81\u5411\u91cf\u5374\u662f\u76f8\u5bf9\u7a33\u5b9a\u7684\u3002\u901a\u8fc7\u5bf9Fisher\u4fe1\u606f\u7684\u77e9\u9635\u5143\u7edf\u8ba1\u3001\u7279\u5f81\u503c\u7edf\u8ba1\u3001\u53c2\u6570\u53d8\u5316\u5728Fisher\u4fe1\u606f\u77e9\u9635\u7279\u5f81\u5411\u91cf\u4e0a\u7684\u6295\u5f71\u7b49\u8fdb\u884c\u5206\u6790\uff0c\u4ed6\u4eec\u63ed\u793a\u51fa\u4e0d\u540c\u5c0f\u9f20\u7684\u5b9e\u9a8c\u7ed3\u679c\u4e2d\u7684\u4e00\u81f4\u6027\u7ed3\u8bba\u3002\u4e3b\u8981\u5305\u542b\u4e0b\u9762\u4e24\u4e2a\u91cd\u8981\u7684\u7ed3\u8bba\uff1a<\/span><\/section>\n